Detailed information for compound 1583218

Basic information

Technical information
  • TDR Targets ID: 1583218
  • Name: N-(2-methoxyphenyl)-1-pyrazin-2-ylpiperidine- 3-carboxamide
  • MW: 312.366 | Formula: C17H20N4O2
  • H donors: 1 H acceptors: 3 LogP: 1.54 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)C1CCCN(C1)c1cnccn1
  • InChi: 1S/C17H20N4O2/c1-23-15-7-3-2-6-14(15)20-17(22)13-5-4-10-21(12-13)16-11-18-8-9-19-16/h2-3,6-9,11,13H,4-5,10,12H2,1H3,(H,20,22)
  • InChiKey: BROCCQDLPSLDDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxyphenyl)-1-pyrazin-2-yl-piperidine-3-carboxamide
  • N-(2-methoxyphenyl)-1-(2-pyrazinyl)-3-piperidinecarboxamide
  • N-(2-methoxyphenyl)-1-pyrazin-2-yl-nipecotamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.00000000018652
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.013 0.0807 0.4826
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0038 0.0205 0.0678
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.014 0.0611
Entamoeba histolytica hypothetical protein 0.0023 0.0104 0.0248
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0069 0.0433
Entamoeba histolytica hypothetical protein 0.0038 0.0205 0.0661
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0 0.0001
Schistosoma mansoni endoplasmin 0.005 0.0284 0.094
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.009 0.0299
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0084 0.0277
Loa Loa (eye worm) hypothetical protein 0.0133 0.0828 0.0828
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0 0.0001
Plasmodium vivax importin-beta 2, putative 0.0029 0.014 0.1029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0221 0.0733
Brugia malayi PHD-finger family protein 0.0031 0.0156 0.0516
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.017 0.0564
Onchocerca volvulus 0.0353 0.2278 0.2278
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0017 0.0134
Onchocerca volvulus 0.0353 0.2278 0.2278
Loa Loa (eye worm) hypothetical protein 0.0246 0.1573 0.1573
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.009 0.0299
Schistosoma mansoni importin beta-1 0.0029 0.014 0.0464
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0212 0.1351 0.593
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0221 0.0733
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.018 0.018
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0034 0.0172 0.0172
Echinococcus granulosus vesicular acetylcholine transporter 0.0465 0.3019 1
Schistosoma mansoni DNA helicase recq5 0.0011 0.0023 0.0076
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0162 0.1018 0.4467
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0236 0.1031
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0 0.0001
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0034 0.0172 0.057
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0212 0.1351 0.593
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Trypanosoma brucei phospholipase A1, putative 0.0353 0.2278 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0 0.0001
Entamoeba histolytica peptidase, C54 family 0.0051 0.0285 0.0991
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0205 0.0678
Brugia malayi jmjC domain containing protein 0.001 0.0017 0.0057
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0144 0.1065
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0871 0.2884
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0284 0.1242
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0103 0.0633 0.2098
Brugia malayi Endoplasmin precursor 0.005 0.0284 0.094
Echinococcus granulosus phd:f box containing protein 0.001 0.0017 0.0057
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.013 0.0807 0.3542
Schistosoma mansoni hypothetical protein 0.001 0.0018 0.006
Brugia malayi TAR-binding protein 0.0139 0.0871 0.2884
Schistosoma mansoni endoplasmin 0.005 0.0284 0.094
Onchocerca volvulus Alhambra homolog 0.0031 0.0156 0.0155
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0066 0.0218
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0284 0.0985
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0 0.0001
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0043 0.0236 0.0781
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.004 0.00000000018652
Trichomonas vaginalis ran, putative 0.0021 0.009 0.0317
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0044 0.019
Entamoeba histolytica peptidase, C54 family 0.013 0.0807 0.314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0 0.0001
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.1007 0.3335
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0269 0.1724 0.7566
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.00000000018652
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0136 0.0136
Brugia malayi RNA, U transporter 1 0.0082 0.0489 0.1619
Schistosoma mansoni ap endonuclease 0.002 0.0084 0.0277
Schistosoma mansoni ran 0.0021 0.009 0.0299
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0084 0.0276
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0465 0.3019 0.3019
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0284 0.1242
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.009 0.0392
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0 0.0001
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.001 0.0017 0.0071
Plasmodium falciparum heat shock protein 90, putative 0.0191 0.1212 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.009 0.0274
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0271 0.1451
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0066 0.0218
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0271 0.1451
Brugia malayi Cytochrome P450 family protein 0.0028 0.0136 0.0449
Trypanosoma cruzi phospholipase A1, putative 0.0353 0.2278 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0789 0.2615
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0 0.0001
Schistosoma mansoni hypothetical protein 0.0373 0.2412 0.7987
Entamoeba histolytica peptidase, C54 family 0.0051 0.0285 0.0991
Mycobacterium ulcerans heat shock protein 90 0.0047 0.0263 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0271 0.0896
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0104 0.0406
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0156 0.0516
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0236 0.0782
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0056 0.0186
Schistosoma mansoni DNA helicase recq1 0.0011 0.0023 0.0076
Brugia malayi isocitrate dehydrogenase 0.0017 0.0066 0.0218
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0017 0.0071
Brugia malayi hypothetical protein 0.0246 0.1573 0.5208
Plasmodium vivax heat shock protein 86, putative 0.005 0.0284 0.2231
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0066 0.0407
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.1573 0.5208
Treponema pallidum heat shock protein 90 0.0047 0.0263 1
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0212 0.1351 0.593
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0343 0.0343
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Schistosoma mansoni heat shock protein 0.005 0.0284 0.094
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.009 0.0611
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0023 0.0076
Toxoplasma gondii heat shock protein 90, putative 0.005 0.0284 0.2335
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0051 0.0285 0.2346
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.004 0.0131
Echinococcus multilocularis 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0053 0.0302 0.0302
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0284 0.1242
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0871 0.2884
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.017 0.0564
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0125 0.0538
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0017 0.0017
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0017 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0 0.0001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.009 0.0611
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0047 0.0263 1
Schistosoma mansoni hypothetical protein 0.0373 0.2412 0.7987
Schistosoma mansoni hypothetical protein 0.005 0.0282 0.0933
Schistosoma mansoni heat shock protein 0.005 0.0284 0.094
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0 0.0001
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0162 0.1018 0.4467
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0727 0.5999
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Loa Loa (eye worm) RNA binding protein 0.0139 0.0871 0.0871
Onchocerca volvulus 0.0353 0.2278 0.2278
Echinococcus multilocularis Peptidase C54 0.013 0.0807 0.2674
Schistosoma mansoni hypothetical protein 0.0008 0.0001 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0007 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0084 0.0277
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.008 0.0265
Leishmania major importin beta-1 subunit, putative 0.0023 0.0104 0.0454
Echinococcus granulosus cpg binding protein 0.0063 0.0365 0.1209
Loa Loa (eye worm) hypothetical protein 0.011 0.0675 0.0675
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0023 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.017 0.0564
Leishmania major hypothetical protein, conserved 0.001 0.0017 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0205 0.0678
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0212 0.1351 0.593
Plasmodium vivax SET domain protein, putative 0.0033 0.017 0.128
Schistosoma mansoni cpg binding protein 0.0063 0.0365 0.1209
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0 0.0001
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.1573 0.5208
Loa Loa (eye worm) heat shock protein 75 0.0034 0.0172 0.0172
Schistosoma mansoni phd/f-box containing protein 0.001 0.0017 0.0057
Brugia malayi AF-10 protein 0.001 0.0018 0.006
Echinococcus multilocularis vesicular acetylcholine transporter 0.0465 0.3019 1
Brugia malayi Importin beta-1 subunit 0.0029 0.014 0.0464
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.013 0.0807 0.4826
Giardia lamblia Heat shock protein HSP 90-alpha 0.0043 0.0236 0.0867
Schistosoma mansoni hypothetical protein 0.0075 0.0446 0.1477
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0066 0.0218
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0156 0.0516
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0001 0.0001
Trypanosoma cruzi Heat shock protein 83, putative 0.005 0.0284 0.1242
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0103 0.0633 0.0633
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0484 0.1603
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0056 0.0186
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0044 0.019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0023 0.0182
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0123 0.0408
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0051 0.0285 0.1247
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0 0.0001
Echinococcus granulosus GPCR family 2 0.0035 0.018 0.0596
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0018 0.0075
Trichomonas vaginalis endoplasmin, putative 0.0037 0.0193 0.096
Plasmodium falciparum endoplasmin, putative 0.0037 0.0193 0.1468
Schistosoma mansoni protein phosphatase 2C 0.001 0.0017 0.0057
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.0596
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0871 0.2884
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0056 0.0186
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0066 0.0285
Echinococcus granulosus heat shock protein 90 0.005 0.0284 0.094
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.014 0.0611
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0023 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.00000000018652
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.017 0.0564
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0066 0.0407
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0084 0.0363
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0271 0.212
Echinococcus granulosus bloom syndrome protein 0.0026 0.0125 0.0415
Entamoeba histolytica Ran family GTPase 0.0021 0.009 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0084 0.0363
Brugia malayi Latrophilin receptor protein 2 0.0035 0.018 0.0596
Plasmodium falciparum heat shock protein 90 0.005 0.0284 0.2231
Trypanosoma brucei Sterol methyltransferase, putative 0.0212 0.1351 0.593
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.018 0.0596
Schistosoma mansoni ap endonuclease 0.002 0.0084 0.0277
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0017 0.0057
Echinococcus granulosus FTZ F1 alpha 0.0007 0 0.0001
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.004 0.0131
Trypanosoma cruzi heat shock protein 90, putative 0.005 0.0284 0.1242
Brugia malayi jmjC domain containing protein 0.001 0.0017 0.0057
Echinococcus granulosus cysteine protease atg4b 0.013 0.0807 0.2674
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0282 0.0933
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.0596
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.0596
Giardia lamblia Grp94/Hsp90 0.0047 0.0263 0.098
Loa Loa (eye worm) hypothetical protein 0.0075 0.0446 0.0446
Schistosoma mansoni nuclear hormone receptor 0.0007 0 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0089 0.0294
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0023 0.0076
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0104 0.0406
Brugia malayi RNA recognition motif domain containing protein 0.0139 0.0871 0.2884
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0084 0.1045
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0446 0.1477
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0125 0.0415
Plasmodium vivax endoplasmin, putative 0.005 0.0284 0.2231
Echinococcus granulosus geminin 0.0373 0.2412 0.7987
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0023 0.0182
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0104 0.0728
Onchocerca volvulus 0.0269 0.1724 0.1723
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0244 0.1898
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0015 0.005
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0244 0.0901
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0 0.0001
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0221 0.0733
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.1037 0.3436
Schistosoma mansoni hypothetical protein 0.0306 0.197 0.6524
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Plasmodium falciparum phd finger protein, putative 0.0031 0.0156 0.1161
Schistosoma mansoni hypothetical protein 0.0031 0.0156 0.0516
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0353 0.2278 0.2278
Entamoeba histolytica hypothetical protein 0.0038 0.0205 0.0661
Brugia malayi nuclear receptor NHR-88 0.0007 0 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0255 0.163 1
Trypanosoma brucei heat shock protein 84, putative 0.0034 0.0172 0.0751
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.013 0.0807 0.3542
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0084 0.0163
Schistosoma mansoni thyroid hormone receptor 0.0007 0 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.00000000018652
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0156 0.0156
Brugia malayi Pre-SET motif family protein 0.0224 0.1428 0.4728
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.009 0.0299
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0 0.0001
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0156 0.0516
Schistosoma mansoni vesicular acetylcholine transporter 0.0465 0.3019 1
Loa Loa (eye worm) cytochrome P450 0.0008 0.0001 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0675 0.2235
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0125 0.0538
Brugia malayi Pre-SET motif family protein 0.0033 0.017 0.0564
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0205 0.0678
Leishmania major lanosterol synthase, putative 0.0192 0.1217 0.5341
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0154 0.051
Trypanosoma brucei lanosterol synthase 0.0192 0.1217 0.5341
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0156 0.1161
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0156 0.1279
Echinococcus multilocularis importin subunit beta 1 0.0029 0.014 0.0464
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.018 0.0596
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0236 0.1232
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0066 0.0535
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0084 0.0084
Echinococcus multilocularis heat shock protein 90 0.0043 0.0236 0.0781
Schistosoma mansoni cpg binding protein 0.0063 0.0365 0.1209
Leishmania major GTP-binding protein, putative 0.0021 0.009 0.0392
Brugia malayi Cytochrome P450 family protein 0.0008 0.0001 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0 0.0001
Loa Loa (eye worm) histone methyltransferase 0.002 0.008 0.008
Entamoeba histolytica peptidase, C54 family 0.0051 0.0285 0.0991
Echinococcus granulosus peregrin 0.0035 0.0183 0.0604
Entamoeba histolytica hypothetical protein 0.0038 0.0205 0.0661
Echinococcus multilocularis heat shock protein 0.005 0.0284 0.094
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0066 0.0218
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0017 0.0071
Brugia malayi vesicular acetylcholine transporter unc-17 0.0465 0.3019 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0017
Brugia malayi ecdysteroid receptor 0.0007 0 0.0001
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0023 0.0076
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0156 0.1279
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.013 0.0807 0.2674
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.018 0.0596
Brugia malayi nuclear hormone receptor 0.0007 0 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0139 0.0871 0.2884
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0014 0.0042 0.0207
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0023 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0675 0.2235
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0017 0.0057
Echinococcus granulosus importin subunit beta 1 0.0029 0.014 0.0464
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Echinococcus multilocularis FTZ F1 alpha 0.0007 0 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.00000000018652
Brugia malayi jmjC domain containing protein 0.0041 0.0221 0.0733
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Brugia malayi Bromodomain containing protein 0.0035 0.0183 0.0604
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0018 0.0075
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0622 0.206
Entamoeba histolytica hypothetical protein 0.0038 0.0205 0.0661
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.1037 0.3436
Schistosoma mansoni ran 0.0021 0.009 0.0299
Loa Loa (eye worm) hypothetical protein 0.013 0.0807 0.0807
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0374 0.0374
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0051 0.0285 0.1247
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.009 0.0392
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0244 0.0822
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0066 0.0285
Loa Loa (eye worm) endoplasmin 0.005 0.0284 0.0284
Brugia malayi jmjC domain containing protein 0.0102 0.0622 0.206
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0871 0.2884
Echinococcus granulosus tar DNA binding protein 0.0139 0.0871 0.2884
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0 0.0001
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0125 0.0415
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0023 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0084 0.0276
Echinococcus granulosus Peptidase C54 0.013 0.0807 0.2674
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0111 0.0681 0.2988
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0145 0.0481
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.018 0.0596
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0622 0.206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.1428 0.1428
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0066 0.0818
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.013 0.0807 0.3542
Echinococcus multilocularis snurportin 1 0.0306 0.197 0.6524
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.1037 0.3436
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0018 0.0141
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.017 0.1397
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0109 0.0669 0.2571
Plasmodium falciparum cysteine protease ATG4, putative 0.0051 0.0285 0.2242
Leishmania major sterol 24-c-methyltransferase, putative 0.0212 0.1351 0.593
Leishmania major hypothetical protein, conserved 0.0269 0.1724 0.7566
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0 0.0001
Brugia malayi PHD-finger family protein 0.0014 0.004 0.0134
Echinococcus granulosus heat shock protein 0.005 0.0284 0.094
Giardia lamblia PHD finger protein 15 0.0031 0.0156 0.0542
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0104 0.0454
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0 0.0001
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.197 0.197
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.018
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0017 0.0057
Schistosoma mansoni cytochrome P450 0.0008 0.0001 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0 0.0001
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.013 0.0807 0.4826
Onchocerca volvulus 0.0059 0.0343 0.0342
Echinococcus multilocularis geminin 0.0373 0.2412 0.7987
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0056 0.0186
Onchocerca volvulus 0.0255 0.163 0.163
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0 0.0001
Loa Loa (eye worm) heat shock protein 90 0.005 0.0284 0.0284
Loa Loa (eye worm) TAR-binding protein 0.0139 0.0871 0.0871
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0001 0.0003
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0066 0.0218
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0017
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0271 0.2226
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0066 0.0285
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0 0.0001
Entamoeba histolytica peptidase, C54 family 0.0051 0.0285 0.0991
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0353 0.2278 0.7544
Trypanosoma cruzi phospholipase A1, putative 0.0353 0.2278 1
Trypanosoma brucei Heat shock protein 83, putative 0.005 0.0284 0.1242
Schistosoma mansoni autophagin-1 (C54 family) 0.013 0.0807 0.2674
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0084 0.0363
Toxoplasma gondii exonuclease III APE 0.002 0.0084 0.0683
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0084 0.0557
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0 0.0001
Toxoplasma gondii Hsp90 domain-containing protein 0.0191 0.1212 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.017 0.0564
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Echinococcus multilocularis peregrin 0.0035 0.0183 0.0604
Giardia lamblia Heat shock protein HSP 90-alpha 0.005 0.0284 0.1063
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0084 0.0277
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Brugia malayi Cytochrome P450 family protein 0.0008 0.0001 0.0003
Brugia malayi cytochrome P450 0.0008 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.013 0.0807 0.4826
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0284 0.1242
Plasmodium vivax heat shock protein, putative 0.0191 0.1212 1
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0033 0.017 0.017
Loa Loa (eye worm) RecQ helicase 0.0026 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0031 0.0156 0.0156
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0066 0.0218
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0212 0.1351 0.593
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.013 0.0807 0.2674
Plasmodium vivax heat shock protein 90, putative 0.0034 0.0172 0.1296
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0104 0.0406
Brugia malayi Phospholipase A2 family protein 0.0398 0.2575 0.8528
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0236 0.0782
Brugia malayi Hsp90 protein 0.0034 0.0172 0.057
Brugia malayi RNA binding protein 0.0139 0.0871 0.2884
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0271 0.2226
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0 0.0001
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0023 0.0076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.018 0.0596
Echinococcus multilocularis GPCR, family 2 0.0035 0.018 0.0596
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0236 0.1031
Trypanosoma cruzi Emopamil binding protein, putative 0.0269 0.1724 0.7566
Toxoplasma gondii heat shock protein HSP90 0.005 0.0284 0.2335
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.004 0.00000000018652
Loa Loa (eye worm) acetyltransferase 0.0165 0.1037 0.1037
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0066 0.0218
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0269 0.1724 0.7566
Trypanosoma cruzi lanosterol synthase, putative 0.0192 0.1217 0.5341
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0284 0.0985
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0051 0.0285 0.1247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0675 0.0675
Brugia malayi steroid hormone receptor 0.0007 0 0.0001
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0383 0.2475 1
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0263 0.1405
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0017 0.0057
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0017 0.0134
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.00000000018652
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0066 0.0218
Echinococcus multilocularis cysteine protease atg4b 0.013 0.0807 0.2674
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0017 0.0057
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0284 0.1242
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0034 0.0172 0.0526
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0066 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0 0.0001
Brugia malayi Peptidase family C54 containing protein 0.013 0.0807 0.2674
Schistosoma mansoni cpg binding protein 0.0059 0.0343 0.1135
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0018 0.0141
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.014 0.1149
Entamoeba histolytica hypothetical protein 0.0109 0.0669 0.2571
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.017 0.0564
Plasmodium falciparum importin beta, putative 0.0029 0.014 0.1029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.013 0.0807 0.4826
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.009 0.0393
Trypanosoma cruzi Emopamil binding protein, putative 0.0269 0.1724 0.7566
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0 0.0001
Brugia malayi jmjC domain containing protein 0.001 0.0017 0.0057
Onchocerca volvulus Phospholipase A2 homolog 0.0398 0.2575 0.2575
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0066 0.0535
Trypanosoma brucei heat shock protein, putative 0.005 0.0284 0.1242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0 0.0001
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0047 0.0263 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0 0.0001
Echinococcus multilocularis cpg binding protein 0.0063 0.0365 0.1209
Brugia malayi Cytochrome P450 family protein 0.0008 0.0001 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0 0.0001
Trypanosoma cruzi lanosterol synthase, putative 0.0192 0.1217 0.5341
Echinococcus granulosus snurportin 1 0.0306 0.197 0.6524
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0263 0.1405
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0017 0.0017
Brugia malayi heat shock protein 90 0.005 0.0284 0.094
Brugia malayi CXXC zinc finger family protein 0.0059 0.0343 0.1135
Echinococcus granulosus heat shock protein 90 0.0043 0.0236 0.0781
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.017 0.0564
Trypanosoma cruzi heat shock protein, putative 0.0034 0.0172 0.0751
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0066 0.0285
Echinococcus granulosus endoplasmin 0.0047 0.0263 0.0872
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0199 0.0659
Leishmania major heat shock protein, putative 0.0034 0.0172 0.0751
Echinococcus multilocularis phd:f box containing protein 0.001 0.0017 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0139 0.0871 0.0871
Onchocerca volvulus Phospholipase A2 homolog 0.1524 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0044 0.0028
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.009 0.0737
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0144 0.0658
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.005 0.0284 0.1242
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0047 0.0263 0.1152
Schistosoma mansoni heat shock protein 0.0034 0.0172 0.057
Onchocerca volvulus 0.005 0.0282 0.0281
Schistosoma mansoni tar DNA-binding protein 0.0139 0.0871 0.2884
Onchocerca volvulus 0.0033 0.017 0.017
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0051 0.0285 0.1247
Echinococcus multilocularis heat shock protein 90 0.005 0.0284 0.094
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0193 0.096
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0047 0.0263 0.3313
Schistosoma mansoni jumonji domain containing protein 0.001 0.0017 0.0057
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0068 0.0549
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0084 0.0557
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0084 0.3154
Schistosoma mansoni thyroid hormone receptor 0.0007 0 0.0001
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0066 0.0066
Leishmania major phospholipase A1, putative 0.0353 0.2278 1
Brugia malayi hypothetical protein 0.0038 0.0205 0.0678
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0017 0.0057
Brugia malayi jmjC domain containing protein 0.001 0.0017 0.0057
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0128 0.0793 1
Leishmania major sterol 24-c-methyltransferase, putative 0.0212 0.1351 0.593
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.009 0.0392
Trypanosoma brucei Emopamil binding protein, putative 0.0269 0.1724 0.7566
Giardia lamblia DNA repair protein RAD52 0.0383 0.2475 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0084 0.0363
Schistosoma mansoni coup transcription factor 0.0007 0 0.0001
Toxoplasma gondii heat shock protein 75, putative 0.0034 0.0172 0.1413
Schistosoma mansoni survival motor neuron protein 0.005 0.0282 0.0933
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.004
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0042 0.0207
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.008 0.0265
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.0596
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.009 0.009
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0269 0.1724 0.7566
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0044 0.019
Echinococcus multilocularis endoplasmin 0.0047 0.0263 0.0872
Loa Loa (eye worm) hypothetical protein 0.0398 0.2575 0.2575
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0001 0.0001
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0465 0.3019 0.3019
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0 0.0001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0084 0.0248
Trichomonas vaginalis heat shock protein, putative 0.005 0.0284 0.1534
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0 0.0001
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0034 0.0172 0.057

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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