Detailed information for compound 1656961

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.306 | Formula: C14H19NO3
  • H donors: 1 H acceptors: 1 LogP: 3.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)Oc1ccccc1OCC1CCCC1
  • InChi: 1S/C14H19NO3/c1-15-14(16)18-13-9-5-4-8-12(13)17-10-11-6-2-3-7-11/h4-5,8-9,11H,2-3,6-7,10H2,1H3,(H,15,16)
  • InChiKey: MJNGKKDDSQXZGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0086 0.023 0.023
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0001 0.0003
Schistosoma mansoni transient receptor potential channel 0.0102 0.0278 0.1367
Echinococcus multilocularis insulin receptor 0.0046 0.0109 0.0142
Loa Loa (eye worm) tubulin alpha-3 chain 0.0197 0.0565 0.5956
Brugia malayi hypothetical protein 0.0017 0.0021 0.0028
Mycobacterium ulcerans cell division protein FtsZ 0.0066 0.017 0.0391
Echinococcus granulosus intermediate filament protein 0.0027 0.005 0.0247
Echinococcus granulosus beta tubulin 0.0152 0.0431 0.2118
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0084 0.0225 0.1103
Trypanosoma brucei alpha tubulin 0.0283 0.0826 0.2966
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.0904 0.3256
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Entamoeba histolytica hypothetical protein 0.0041 0.0093 0.1117
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0494 0.5977
Mycobacterium ulcerans hypothetical protein 0.0035 0.0076 0.0127
Echinococcus multilocularis Tubulin beta 2C chain 0.0152 0.0431 0.0558
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0889
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0051 0.0058
Toxoplasma gondii alpha-tubulin I, putative 0.0283 0.0826 0.3048
Brugia malayi topoisomerase 0.0021 0.0032 0.0044
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0001 0.0001
Trichomonas vaginalis tubulin beta chain, putative 0.0283 0.0826 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0137 0.0503
Schistosoma mansoni hypothetical protein 0.0086 0.0229 0.1125
Schistosoma mansoni tubulin subunit beta 0.0152 0.0431 0.2116
Echinococcus granulosus tubulin alpha 1C chain 0.0283 0.0826 0.4064
Echinococcus granulosus alpha tubulin 0.0283 0.0826 0.4064
Trypanosoma brucei epsilon tubulin 0.0152 0.0431 0.1488
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0174 0.0225
Plasmodium vivax tubulin gamma chain, putative 0.0152 0.0431 0.1587
Trypanosoma brucei alpha tubulin 0.0283 0.0826 0.2966
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0061 0.0108
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.023 0.2783
Echinococcus granulosus tubulin subunit beta 0.0152 0.0431 0.2118
Schistosoma mansoni tubulin subunit beta 0.0066 0.017 0.0832
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.1352 0.6652
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.056 0.0725
Echinococcus multilocularis muscleblind protein 0.0148 0.0416 0.0539
Brugia malayi beta-lactamase 0.0035 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.034
Trichomonas vaginalis tubulin alpha chain, putative 0.0152 0.0431 0.5208
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0076 0.0372
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0904 0.3256
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0051 0.0058
Loa Loa (eye worm) tubulin alpha chain 0.0283 0.0826 0.8704
Schistosoma mansoni tubulin subunit beta 0.0152 0.0431 0.2116
Trichomonas vaginalis tubulin epsilon chain, putative 0.0283 0.0826 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Trichomonas vaginalis tubulin beta chain, putative 0.0152 0.0431 0.5208
Loa Loa (eye worm) tubulin beta-1 chain 0.0152 0.0431 0.4536
Echinococcus granulosus tubulin alpha chain 0.0283 0.0826 0.4064
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0032 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0319
Plasmodium falciparum lipid/sterol:H+ symporter 0.0013 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.0276 0.0804 0.847
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.0454 0.0625
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.005 0.0068
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0205 0.0265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0123 0.0605
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.0407 0.0527
Schistosoma mansoni tubulin subunit epsilon 0.0152 0.0431 0.2116
Echinococcus granulosus tubulin alpha 3 chain 0.0283 0.0826 0.4064
Brugia malayi alpha-tubulin 0.0283 0.0826 0.1137
Trypanosoma cruzi zeta tubulin, putative 0.0066 0.017 0.0513
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0076 0.0098
Mycobacterium ulcerans beta-lactamase 0.0035 0.0076 0.0127
Echinococcus granulosus lysine specific histone demethylase 1A 0.0084 0.0225 0.1106
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0003
Giardia lamblia Alpha-tubulin 0.0283 0.0826 0.2966
Echinococcus granulosus lamin dm0 0.0027 0.005 0.0247
Echinococcus granulosus peroxisome assembly protein 26 0.0283 0.0826 0.4064
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0528
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.005 0.0065
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0084 0.0225 0.0828
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0051 0.0185
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0051 0.0123 0.0602
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0032 0.0383
Echinococcus granulosus expressed conserved protein 0.0195 0.0559 0.2752
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0276 0.0804 0.1107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Onchocerca volvulus 0.0276 0.0804 0.0803
Echinococcus multilocularis Tubulin beta 2C chain 0.0152 0.0431 0.0558
Schistosoma mansoni tyrosine kinase 0.0078 0.0205 0.1003
Plasmodium vivax importin-beta 2, putative 0.003 0.0061 0.0224
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Brugia malayi Patched related family protein 12 0.0013 0.0008 0.001
Onchocerca volvulus 0.0084 0.0225 0.0224
Schistosoma mansoni tyrosine kinase 0.0046 0.0109 0.0535
Loa Loa (eye worm) hypothetical protein 0.0207 0.0597 0.6294
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0005 0.0027
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0001 0.0001
Schistosoma mansoni tubulin subunit delta 0.0066 0.017 0.0832
Entamoeba histolytica hypothetical protein 0.0041 0.0093 0.1117
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.2033 0.2632
Brugia malayi hypothetical protein 0.0013 0.0008 0.001
Mycobacterium leprae Probable lipase LipE 0.0035 0.0076 0.2252
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0084 0.0225 0.0828
Brugia malayi tubulin alpha chain - mouse 0.0283 0.0826 0.1137
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0076 0.0127
Loa Loa (eye worm) tubulin alpha 2 0.0217 0.0626 0.6595
Echinococcus granulosus tubulin alpha chain 0.0283 0.0826 0.4064
Echinococcus multilocularis Tubulin alpha 1 chain 0.0283 0.0826 0.107
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.056 0.275
Schistosoma mansoni tubulin subunit alpha 0.0283 0.0826 0.4063
Echinococcus multilocularis hypothetical protein 0.0283 0.0826 0.107
Schistosoma mansoni tubulin subunit alpha 0.0066 0.017 0.0832
Plasmodium falciparum tubulin gamma chain 0.0152 0.0431 0.1587
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0101 0.0256
Echinococcus granulosus Tubulin alpha 1 chain 0.0283 0.0826 0.4064
Schistosoma mansoni hypothetical protein 0.0416 0.1229 0.6043
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Trypanosoma cruzi tubulin delta chain 0.0066 0.017 0.0513
Toxoplasma gondii RNA-directed DNA polymerase 0.0905 0.2709 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0076 0.0127
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0213 0.2568
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0037 0.0182
Plasmodium vivax telomerase reverse transcriptase, putative 0.0905 0.2709 1
Plasmodium vivax tubulin alpha chain, putative 0.0283 0.0826 0.3048
Echinococcus granulosus tubulin alpha 1C chain 0.0283 0.0826 0.4064
Trichomonas vaginalis tubulin alpha chain, putative 0.0152 0.0431 0.5208
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0797
Brugia malayi Tubulin alpha-2 chain 0.0283 0.0826 0.1137
Brugia malayi Patched protein homolog 1 0.0013 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0073
Plasmodium falciparum tubulin delta chain, putative 0.0066 0.017 0.0624
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0319
Chlamydia trachomatis DNA ligase 0.0021 0.0032 0.0172
Leishmania major UDP-galactopyranose mutase 0.0084 0.0225 0.0828
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0276 0.0804 0.1107
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0084 0.0415
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0051 0.015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Echinococcus granulosus tubulin subunit TubB 0.0283 0.0826 0.4064
Entamoeba histolytica tubulin alpha chain, putative 0.0283 0.0826 1
Echinococcus granulosus tubulin gamma 1 chain 0.0152 0.0431 0.2118
Brugia malayi TAR-binding protein 0.0134 0.0375 0.0516
Entamoeba histolytica hypothetical protein 0.0025 0.0044 0.0524
Echinococcus multilocularis tubulin gamma 1 chain 0.0152 0.0431 0.0558
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Schistosoma mansoni tubulin subunit beta 0.0152 0.0431 0.2116
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0383
Echinococcus granulosus Tubulin alpha 1 chain 0.0283 0.0826 0.4064
Echinococcus granulosus tubulin alpha chain 0.0283 0.0826 0.4064
Brugia malayi hypothetical protein 0.0013 0.0008 0.001
Toxoplasma gondii patched family protein 0.0013 0.0008 0.0026
Brugia malayi Niemann-Pick C1 protein precursor 0.0207 0.0597 0.0822
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.0909
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0076 0.0225
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0134
Onchocerca volvulus 0.0013 0.0008 0.0007
Loa Loa (eye worm) tyrosinase 1 0.0276 0.0804 0.847
Trichomonas vaginalis ran, putative 0.0022 0.0037 0.0441
Loa Loa (eye worm) hypothetical protein 0.0148 0.0416 0.4384
Schistosoma mansoni hypothetical protein 0.0666 0.1986 0.9768
Echinococcus granulosus tubulin epsilon chain 0.0152 0.0431 0.2118
Entamoeba histolytica tubulin family protein 0.0152 0.0431 0.5208
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0467 0.5653
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0174 0.0225
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0375 0.0516
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0058 0.061
Brugia malayi Tubulin alpha-2 chain 0.0283 0.0826 0.1137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0157 0.077
Echinococcus multilocularis tubulin alpha chain 0.0283 0.0826 0.107
Mycobacterium leprae cell division protein FtsZ 0.0066 0.017 0.7135
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0066 0.017 0.2048
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0032 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0061 0.0646
Echinococcus granulosus cpg binding protein 0.0031 0.0063 0.031
Trichomonas vaginalis tubulin epsilon chain, putative 0.0152 0.0431 0.5208
Echinococcus granulosus Tubulin alpha 1 chain 0.0283 0.0826 0.4064
Echinococcus granulosus transient receptor potential ion channel A 0.0099 0.0268 0.1319
Echinococcus multilocularis tubulin alpha 1C chain 0.0283 0.0826 0.107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0728 0.8813
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0076 0.0127
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.005 0.0181
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.056 0.5895
Loa Loa (eye worm) intermediate filament protein 0.0027 0.005 0.0528
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0008 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0076 0.0103
Schistosoma mansoni tubulin subunit beta 0.0152 0.0431 0.2116
Toxoplasma gondii patched family protein 0.0013 0.0008 0.0026
Schistosoma mansoni lamin 0.0027 0.005 0.0243
Echinococcus granulosus Tubulin beta 2C chain 0.0152 0.0431 0.2118
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0619 0.1842 0.5513
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.0162
Schistosoma mansoni cpg binding protein 0.0031 0.0063 0.0307
Loa Loa (eye worm) hypothetical protein 0.0283 0.0826 0.8704
Leishmania major telomerase reverse transcriptase, putative 0.0905 0.2709 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0076 0.0909
Schistosoma mansoni hypothetical protein 0.0041 0.0093 0.0454
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.0162
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.2369
Trichomonas vaginalis tubulin gamma chain, putative 0.0152 0.0431 0.5208
Loa Loa (eye worm) hypothetical protein 0.0148 0.0416 0.4384
Loa Loa (eye worm) ShTK domain-containing protein 0.0276 0.0804 0.847
Trichomonas vaginalis tubulin beta chain, putative 0.0283 0.0826 1
Leishmania major gamma-tubulin 0.0152 0.0431 0.1587
Echinococcus granulosus Tubulin beta 2C chain 0.0152 0.0431 0.2118
Echinococcus multilocularis sterol regulatory element binding protein 0.0089 0.0239 0.0309
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.2369
Brugia malayi hypothetical protein 0.0041 0.0093 0.0127
Trichomonas vaginalis tubulin, putative 0.0086 0.023 0.2783
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0123 0.1295
Schistosoma mansoni lamin 0.0027 0.005 0.0243
Loa Loa (eye worm) hypothetical protein 0.0064 0.0164 0.1723
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0051 0.0069
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0032 0.0159
Toxoplasma gondii hypothetical protein 0.0013 0.0008 0.0026
Echinococcus multilocularis tubulin beta 1 chain 0.0152 0.0431 0.0558
Echinococcus multilocularis peroxisome assembly protein 26 0.0283 0.0826 0.107
Leishmania major importin beta-1 subunit, putative 0.0025 0.0044 0.016
Mycobacterium ulcerans hypothetical protein 0.0163 0.0462 0.121
Loa Loa (eye worm) alpha-tubulin 0.0283 0.0826 0.8704
Loa Loa (eye worm) tubulin gamma chain 0.0152 0.0431 0.4536
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Brugia malayi tubulin alpha-2 chain 0.0283 0.0826 0.1137
Giardia lamblia Epsilon tubulin 0.0066 0.017 0.0513
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0084 0.0225 0.0828
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0513
Trypanosoma brucei tubulin delta chain 0.0066 0.017 0.0513
Toxoplasma gondii alpha tubulin TUBA1 0.0283 0.0826 0.3048
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0032 0.0117
Echinococcus granulosus neuropeptide s receptor 0.0457 0.1352 0.6652
Brugia malayi Patched related family protein 10 0.0013 0.0008 0.001
Onchocerca volvulus Protein patched homolog 0.0013 0.0008 0.0007
Entamoeba histolytica tubulin alpha-1 chain 0.0283 0.0826 1
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.1352 0.1751
Schistosoma mansoni amine oxidase 0.0084 0.0225 0.1103
Echinococcus granulosus lysine specific histone demethylase 1A 0.0084 0.0225 0.1106
Entamoeba histolytica Ran family GTPase 0.0022 0.0037 0.0441
Echinococcus granulosus Tubulin beta 2C chain 0.0152 0.0431 0.2118
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.013 0.0364
Plasmodium vivax tubulin beta chain, putative 0.0152 0.0431 0.1587
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0013 0.0134
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0619 0.1842 0.6798
Plasmodium falciparum alpha tubulin 2 0.0283 0.0826 0.3048
Toxoplasma gondii histone lysine-specific demethylase 0.0084 0.0225 0.0828
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.003 0.0089
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Loa Loa (eye worm) tubulin alpha 2 0.0217 0.0626 0.6595
Trichomonas vaginalis tubulin beta chain, putative 0.0283 0.0826 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0032 0.0383
Brugia malayi RNA binding protein 0.0134 0.0375 0.0516
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.005
Schistosoma mansoni tyrosine kinase 0.0145 0.0407 0.1999
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0093 0.0457
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0467 0.0467
Trypanosoma cruzi alpha tubulin, putative 0.0283 0.0826 0.2966
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0066 0.017 0.0759
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Trypanosoma brucei zeta tubulin 0.0066 0.017 0.0513
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0217 0.0626 0.6595
Loa Loa (eye worm) beta-lactamase 0.0035 0.0076 0.0797
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0197 0.0565 0.684
Echinococcus multilocularis Tubulin beta 2C chain 0.0152 0.0431 0.0558
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.0949 1
Schistosoma mansoni cpg binding protein 0.0031 0.0063 0.0307
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0412 0.1418
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Schistosoma mansoni hypothetical protein 0.0051 0.0123 0.0602
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.005 0.0528
Plasmodium vivax delta tubulin, putative 0.0066 0.017 0.0624
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Trichomonas vaginalis tubulin beta chain, putative 0.0283 0.0826 1
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0619 0.1842 0.5081
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0066 0.017 0.0624
Schistosoma mansoni topbp1 0.0021 0.0032 0.0156
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.2033 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0283 0.0826 0.107
Plasmodium vivax tubulin epsilon chain, putative 0.0152 0.0431 0.1587
Echinococcus multilocularis snurportin 1 0.0324 0.0949 0.1229
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0032 0.0006
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0467 0.5653
Schistosoma mansoni hypothetical protein 0.0666 0.1986 0.9768
Brugia malayi Cell division protein ftsZ 0.0066 0.017 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0375 0.1842
Schistosoma mansoni tyrosine kinase 0.0077 0.0202 0.0991
Loa Loa (eye worm) hypothetical protein 0.0276 0.0804 0.847
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Loa Loa (eye worm) TK/EGFR protein kinase 0.0145 0.0407 0.4287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0027 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0383
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1114 0.3341 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0061 0.0079
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0076 0.0225
Schistosoma mansoni hypothetical protein 0.0086 0.0229 0.1125
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0084 0.0225 0.1103
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0225 0.0719
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0728 0.8813
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.023 0.2783
Trichomonas vaginalis tubulin, putative 0.0066 0.017 0.2048
Mycobacterium tuberculosis Possible oxidoreductase 0.0084 0.0225 0.0671
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.2369
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0619 0.1842 0.6798
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0535
Echinococcus multilocularis tubulin alpha 3 chain 0.0283 0.0826 0.107
Schistosoma mansoni alpha tubulin 0.0283 0.0826 0.4063
Onchocerca volvulus 0.0013 0.0008 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0076 0.0225
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0213 0.2568
Echinococcus granulosus tubulin beta 1 chain 0.0152 0.0431 0.2118
Loa Loa (eye worm) patched family protein 0.0013 0.0008 0.008
Onchocerca volvulus 0.0027 0.0051 0.005
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0084 0.0225 0.0546
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0032 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0728 0.8813
Schistosoma mansoni ran 0.0022 0.0037 0.0179
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0467 0.5653
Toxoplasma gondii hypothetical protein 0.005 0.012 0.0441
Toxoplasma gondii beta tubulin 0.0152 0.0431 0.1587
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Plasmodium falciparum telomerase reverse transcriptase 0.0905 0.2709 1
Echinococcus granulosus sterol regulatory element binding protein 0.0089 0.0239 0.1176
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0001 0.0007
Trypanosoma brucei alpha tubulin 0.0283 0.0826 0.2966
Echinococcus granulosus tubulin alpha 3 chain 0.0283 0.0826 0.4064
Loa Loa (eye worm) patched family protein 0.0013 0.0008 0.008
Schistosoma mansoni transient receptor potential channel 0.0068 0.0174 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.017 0.2048
Brugia malayi Protein kinase domain containing protein 0.0046 0.0109 0.015
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.0225
Mycobacterium ulcerans monoamine oxidase 0.0084 0.0225 0.0546
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.056 0.077
Trypanosoma cruzi beta tubulin, putative 0.0152 0.0431 0.1488
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0076 0.0162
Toxoplasma gondii beta-1 tubulin, putative 0.0152 0.0431 0.1587
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0123 0.0159
Trypanosoma brucei beta tubulin 0.0152 0.0431 0.1488
Schistosoma mansoni tubulin subunit alpha 0.0283 0.0826 0.4063
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0205 0.1006
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0032 0.0044
Schistosoma mansoni tyrosine kinase 0.0077 0.0202 0.0991
Trichomonas vaginalis tubulin, putative 0.0152 0.0431 0.5208
Mycobacterium tuberculosis Conserved hypothetical protein 0.0084 0.0225 0.0671
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0416 0.0539
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Trypanosoma brucei alpha tubulin 0.0283 0.0826 0.2966
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0375 0.1842
Onchocerca volvulus 0.0276 0.0804 0.0803
Leishmania major GTP-binding protein, putative 0.0022 0.0037 0.0134
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0904 0.3256
Entamoeba histolytica hypothetical protein 0.0041 0.0093 0.1117
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0797
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.0454 0.4786
Echinococcus multilocularis musashi 0.0027 0.005 0.0065
Chlamydia trachomatis protoporphyrinogen oxidase 0.0084 0.0225 0.1218
Leishmania major hypothetical protein, conserved 0.0035 0.0076 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0375 0.1842
Giardia lamblia Beta tubulin 0.0152 0.0431 0.1488
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0797
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Brugia malayi hypothetical protein 0.0084 0.0225 0.0309
Trichomonas vaginalis tubulin epsilon chain, putative 0.0283 0.0826 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.039
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1198 0.3596 1
Brugia malayi Patched related family protein 4 0.0013 0.0008 0.001
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0086 0.023 0.0848
Brugia malayi Myosin head containing protein 0.0013 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0797
Loa Loa (eye worm) hypothetical protein 0.0109 0.03 0.3156
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0044 0.0043
Trichomonas vaginalis tubulin beta chain, putative 0.0283 0.0826 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0211 0.0607 0.2984
Echinococcus granulosus tubulin beta 4A class IVa 0.0152 0.0431 0.2118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.034
Echinococcus granulosus beta tubulin 0.0152 0.0431 0.2118
Loa Loa (eye worm) BEN-1 protein 0.0152 0.0431 0.4536
Brugia malayi CXXC zinc finger family protein 0.0029 0.0058 0.0079
Loa Loa (eye worm) BEN-1 protein 0.0152 0.0431 0.4536
Echinococcus multilocularis protoporphyrinogen oxidase 0.0084 0.0225 0.0291
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.003 0.0161
Schistosoma mansoni tyrosine kinase 0.0078 0.0205 0.1003
Echinococcus granulosus Tubulin beta 2C chain 0.0152 0.0431 0.2118
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0032 0.0383
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.003 0.0109
Echinococcus multilocularis tubulin alpha chain 0.0283 0.0826 0.107
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0276 0.0804 0.1107
Schistosoma mansoni hypothetical protein 0.0051 0.0123 0.0602
Echinococcus granulosus microtubule associated protein 2 0.0682 0.2033 1
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.1229 0.1591
Echinococcus multilocularis Tubulin alpha 1 chain 0.0283 0.0826 0.107
Mycobacterium tuberculosis Cell division protein FtsZ 0.0066 0.017 0.0506
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0797
Onchocerca volvulus 0.0027 0.005 0.0049
Echinococcus multilocularis GPCR, family 2 0.0051 0.0123 0.0159
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Brugia malayi SWIRM domain containing protein 0.0084 0.0225 0.0309
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0024
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0061 0.0224
Onchocerca volvulus 0.0035 0.0076 0.0075
Loa Loa (eye worm) patched family protein 0.0013 0.0008 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0076 0.0225
Trichomonas vaginalis tubulin beta chain, putative 0.0086 0.023 0.2783
Loa Loa (eye worm) tubulin beta chain 0.0152 0.0431 0.4536
Trypanosoma brucei beta tubulin 0.0152 0.0431 0.1488
Loa Loa (eye worm) tubulin beta-4 chain 0.0152 0.0431 0.4536
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0239 0.2887
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Giardia lamblia Alpha-tubulin 0.0283 0.0826 0.2966
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0781
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0467 0.5653
Echinococcus granulosus snurportin 1 0.0324 0.0949 0.467
Echinococcus multilocularis beta tubulin 0.0152 0.0431 0.0558
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0027 0.0079
Echinococcus multilocularis tubulin subunit TubB 0.0283 0.0826 0.107
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0283 0.0826 1
Onchocerca volvulus 0.0013 0.0008 0.0007
Schistosoma mansoni alpha tubulin 0.0283 0.0826 0.4063
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0032 0.0117
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0535
Schistosoma mansoni tubulin subunit alpha 0.0283 0.0826 0.4063
Echinococcus multilocularis Niemann Pick C1 protein 0.0297 0.0867 0.1123
Brugia malayi ShTK domain containing protein 0.0276 0.0804 0.1107
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.005 0.0181
Echinococcus granulosus geminin 0.0666 0.1986 0.9768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0383
Loa Loa (eye worm) hypothetical protein 0.0027 0.0051 0.0535
Brugia malayi hypothetical protein 0.0021 0.0032 0.0044
Brugia malayi DKFZp564C0469 protein 0.0021 0.0032 0.0044
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0084 0.0115
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0619 0.1842 1
Schistosoma mansoni tyrosine kinase 0.0046 0.0109 0.0535
Schistosoma mansoni transient receptor potential channel 4 0.0102 0.0278 0.1367
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0001 0.0003
Schistosoma mansoni tubulin subunit beta 0.0152 0.0431 0.2116
Trypanosoma brucei epsilon tubulin 0.0152 0.0431 0.1488
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0051 0.0069
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2562 0.7723 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0076 0.2252
Echinococcus multilocularis transient receptor potential gamma protein 0.0102 0.0278 0.0361
Brugia malayi Telomerase reverse transcriptase 0.2409 0.726 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0051 0.0058
Trichomonas vaginalis tubulin epsilon chain, putative 0.0152 0.0431 0.5208
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0037 0.0018
Echinococcus multilocularis Tubulin beta 2C chain 0.0152 0.0431 0.0558
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.0909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.056 0.275
Schistosoma mansoni transient receptor potential channel 0.0068 0.0174 0.0852
Schistosoma mansoni DNA ligase IV 0.0021 0.0032 0.0156
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0032 0.0117
Brugia malayi hypothetical protein 0.0021 0.0032 0.0044
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0084 0.0225 0.0828
Echinococcus granulosus insulin receptor 0.0046 0.0109 0.0538
Trypanosoma brucei beta tubulin 0.0152 0.0431 0.1488
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0728 0.8813
Echinococcus multilocularis protein dispatched 1 0.0102 0.0277 0.0359
Loa Loa (eye worm) ShTK domain-containing protein 0.0276 0.0804 0.847
Onchocerca volvulus 0.0013 0.0008 0.0007
Echinococcus multilocularis tubulin subunit beta 0.0152 0.0431 0.0558
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0369
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0728 0.8813
Echinococcus multilocularis 0.0045 0.0105 0.0136
Plasmodium falciparum acyl-CoA synthetase 0.002 0.003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.034
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0109 0.0142
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Trypanosoma cruzi tubulin gamma chain 0.0152 0.0431 0.1488
Echinococcus granulosus Tubulin beta 2C chain 0.0152 0.0431 0.2118
Giardia lamblia Beta tubulin 0.0152 0.0431 0.1488
Echinococcus multilocularis protein patched 0.0089 0.0239 0.0309
Schistosoma mansoni importin beta-1 0.003 0.0061 0.0298
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0123 0.0168
Plasmodium vivax patched family protein, putative 0.0013 0.0008 0.0026
Schistosoma mansoni hypothetical protein 0.0324 0.0949 0.4668
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0797
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Echinococcus granulosus Niemann Pick C1 protein 0.0207 0.0597 0.2939
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0076 0.0225
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0619 0.1842 0.5081
Echinococcus granulosus tubulin delta chain 0.0066 0.017 0.0835
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0152 0.0431 0.1587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.056 0.0725
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Echinococcus multilocularis tubulin alpha chain 0.0283 0.0826 0.107
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Mycobacterium ulcerans dehydrogenase 0.0084 0.0225 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.017 0.2048
Plasmodium falciparum tubulin beta chain 0.0152 0.0431 0.1587
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0076 0.0797
Trypanosoma cruzi epsilon tubulin, putative 0.0152 0.0431 0.1488
Giardia lamblia Beta tubulin 0.0152 0.0431 0.1488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.056 0.275
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.2369
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Schistosoma mansoni amine oxidase 0.0084 0.0225 0.1103
Plasmodium falciparum tubulin epsilon chain, putative 0.0152 0.0431 0.1587
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Entamoeba histolytica hypothetical protein 0.0021 0.0032 0.0383
Loa Loa (eye worm) patched family protein 0.0013 0.0008 0.008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.2369
Treponema pallidum cell division protein FtsZ 0.0066 0.017 1
Brugia malayi Tubulin alpha chain 0.0283 0.0826 0.1137
Leishmania major epsilon tubulin, putative 0.0152 0.0431 0.1587
Giardia lamblia Gamma tubulin 0.0152 0.0431 0.1488
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0084 0.0225 0.0291
Entamoeba histolytica hypothetical protein 0.0041 0.0093 0.1117
Echinococcus multilocularis tubulin alpha 3 chain 0.0283 0.0826 0.107
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0001 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0051 0.015
Echinococcus multilocularis lamin dm0 0.0027 0.005 0.0065
Toxoplasma gondii beta-tubulin, putative 0.0152 0.0431 0.1587
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0905 0.2709 1
Trypanosoma brucei alpha tubulin, putative 0.0086 0.023 0.074
Echinococcus granulosus tubulin alpha chain 0.0283 0.0826 0.4064
Brugia malayi amine oxidase, flavin-containing family protein 0.0084 0.0225 0.0309
Leishmania major hypothetical protein, conserved 0.0027 0.005 0.0181
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0037 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0375 0.1842
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0044 0.0524
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0728 0.8813
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.1352 0.1751
Onchocerca volvulus 0.0013 0.0008 0.0007
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0213 0.2568
Trichomonas vaginalis esterase, putative 0.0035 0.0076 0.0909
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0051 0.0961
Brugia malayi Importin beta-1 subunit 0.003 0.0061 0.0084
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0375 0.3951
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0066 0.017 0.0624
Brugia malayi Common central domain of tyrosinase family protein 0.0276 0.0804 0.1107
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0005 0.0007
Giardia lamblia Telomerase catalytic subunit 0.0905 0.2709 1
Entamoeba histolytica tubulin family protein 0.0152 0.0431 0.5208
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0051 0.0069
Echinococcus multilocularis Tubulin alpha 1 chain 0.0283 0.0826 0.107
Trypanosoma brucei beta tubulin 0.0152 0.0431 0.1488
Schistosoma mansoni hypothetical protein 0.011 0.0301 0.1478
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0037 0.0134
Onchocerca volvulus 0.0276 0.0804 0.0803
Loa Loa (eye worm) tubulin alpha chain 0.0283 0.0826 0.8704
Echinococcus multilocularis 0.0084 0.0225 0.0291
Echinococcus multilocularis nibrin 0.0021 0.0032 0.0042
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Echinococcus multilocularis transient receptor potential ion channel A 0.0099 0.0268 0.0347
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0051 0.0185
Schistosoma mansoni tubulin subunit beta 0.0152 0.0431 0.2116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.056 0.2753
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Schistosoma mansoni tubulin subunit gamma 0.0152 0.0431 0.2116
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.0365 0.3846
Loa Loa (eye worm) hypothetical protein 0.0197 0.0565 0.5956
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0467 0.5653
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Onchocerca volvulus 0.0027 0.005 0.0049
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0905 0.2709 1
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0076 0.0225
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0084 0.0225 1
Echinococcus multilocularis lamin 0.0027 0.005 0.0065
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0217 0.0626 0.7575
Echinococcus granulosus muscleblind protein 0.0148 0.0416 0.2047
Echinococcus granulosus tar DNA binding protein 0.0134 0.0375 0.1845
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0369
Loa Loa (eye worm) hypothetical protein 0.0217 0.0626 0.6595
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0051 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0467 0.5653
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0524
Loa Loa (eye worm) hypothetical protein 0.016 0.0454 0.4786
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0037 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0051 0.0058
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0032 0.0117
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.0407 0.2002
Echinococcus multilocularis geminin 0.0666 0.1986 0.2571
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.0225
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.0032 0.0383
Echinococcus multilocularis expressed conserved protein 0.0195 0.0559 0.0724
Echinococcus multilocularis tubulin alpha 0.0152 0.0431 0.0558
Onchocerca volvulus Protein patched homolog 0.0013 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0319
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.0225
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0089 0.0239 0.2517
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0027 0.0079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Loa Loa (eye worm) RNA binding protein 0.0134 0.0375 0.3951
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0051 0.0607
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Toxoplasma gondii ABC1 family protein 0.0035 0.0076 0.0277
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0123 0.0159
Loa Loa (eye worm) hypothetical protein 0.011 0.0301 0.317
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Brugia malayi hypothetical protein 0.0027 0.005 0.0068
Trypanosoma brucei beta tubulin 0.0152 0.0431 0.1488
Brugia malayi intermediate filament protein 0.0027 0.005 0.0068
Schistosoma mansoni patched 1 0.0089 0.0239 0.1173
Trypanosoma cruzi epsilon tubulin, putative 0.0152 0.0431 0.1488
Trypanosoma cruzi UDP-galactopyranose mutase 0.0084 0.0225 0.0719
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0051 0.0607
Trichomonas vaginalis tubulin, putative 0.0086 0.023 0.2783
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0051 0.0607
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0412 0.1418
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.005 0.0181
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0101 0.0256
Schistosoma mansoni hypothetical protein 0.0051 0.0123 0.0602
Echinococcus granulosus nibrin 0.0021 0.0032 0.0159
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0101 0.0256
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0174 0.0855
Echinococcus granulosus GPCR family 2 0.0051 0.0123 0.0605
Leishmania major zeta tubulin, putative 0.0066 0.017 0.0624
Brugia malayi Muscleblind-like protein 0.0148 0.0416 0.0572
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0089 0.0239 0.2517
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0044 0.0524
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Brugia malayi Tubulin alpha chain 0.0066 0.017 0.0233
Plasmodium falciparum importin beta, putative 0.003 0.0061 0.0224
Trichomonas vaginalis tubulin beta chain, putative 0.0283 0.0826 1
Schistosoma mansoni hypothetical protein 0.0086 0.0229 0.1125
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.0728 0.1002
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Onchocerca volvulus 0.0021 0.0032 0.0032
Plasmodium vivax tubulin alpha chain, putative 0.0283 0.0826 0.3048
Brugia malayi Tubulin beta-1 chain 0.0152 0.0431 0.0592
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0375 0.1842
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0076 0.0909
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0101 0.0256
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0093 0.012
Echinococcus multilocularis tubulin alpha chain 0.0283 0.0826 0.107
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0467 0.5653
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0123 0.0168
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0051 0.0058
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0051 0.0058
Brugia malayi protein C24B5.3 0.0013 0.0008 0.001
Trichomonas vaginalis tubulin alpha chain, putative 0.0086 0.023 0.2783
Echinococcus multilocularis Niemann Pick C1 protein 0.0207 0.0597 0.0774
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0319
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0109 0.0538
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Schistosoma mansoni topbp1 0.0021 0.0032 0.0156
Echinococcus multilocularis Tubulin beta 2C chain 0.0152 0.0431 0.0558
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0093 0.0454
Echinococcus multilocularis tubulin delta chain 0.0066 0.017 0.022
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0152 0.0431 0.0558
Schistosoma mansoni intermediate filament proteins 0.0027 0.005 0.0243
Schistosoma mansoni tyrosinase precursor 0.0276 0.0804 0.3953
Trichomonas vaginalis tubulin gamma chain, putative 0.0152 0.0431 0.5208
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0462 0.138
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0076 0.0277
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.005 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0007
Brugia malayi Tubulin beta chain 0.0086 0.023 0.0316
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0051 0.0961
Trypanosoma cruzi tubulin delta chain 0.0066 0.017 0.0513
Loa Loa (eye worm) patched family protein 0.0013 0.0008 0.008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.034
Echinococcus granulosus Niemann Pick C1 protein 0.0297 0.0867 0.4264
Schistosoma mansoni alpha tubulin 0.0283 0.0826 0.4063
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0619 0.1842 0.5081
Onchocerca volvulus 0.0029 0.0058 0.0057
Echinococcus multilocularis beta tubulin 0.0152 0.0431 0.0558
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0225 0.0828
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.034
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0007
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.017 0.2048
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1198 0.3596 1
Onchocerca volvulus 0.0013 0.0008 0.0007
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0174 0.0855
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Brugia malayi CHE-14 protein 0.0089 0.0239 0.0328
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0375 0.3951
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0619 0.1842 1
Echinococcus granulosus tubulin alpha 0.0152 0.0431 0.2118
Trypanosoma brucei zeta tubulin, putative 0.0066 0.017 0.0513
Trypanosoma brucei telomerase reverse transcriptase 0.0905 0.2709 1
Echinococcus granulosus tubulin alpha chain 0.0283 0.0826 0.4064
Trichomonas vaginalis tubulin gamma chain, putative 0.0152 0.0431 0.5208
Plasmodium falciparum alpha tubulin 1 0.0283 0.0826 0.3048
Brugia malayi Tubulin gamma chain 0.0152 0.0431 0.0592
Toxoplasma gondii patched family protein 0.0013 0.0008 0.0026
Schistosoma mansoni cpg binding protein 0.0029 0.0058 0.0282
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.005 0.0065
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.0904 0.3335
Leishmania major alpha tubulin 0.0283 0.0826 0.3048
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0205 0.1006
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0086 0.023 0.2783
Echinococcus granulosus lamin 0.0027 0.005 0.0247
Onchocerca volvulus 0.0035 0.0076 0.0075
Schistosoma mansoni hypothetical protein 0.0086 0.0229 0.1125
Echinococcus granulosus transient receptor potential gamma protein 0.0102 0.0278 0.137
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0032 0.0383
Echinococcus granulosus importin subunit beta 1 0.003 0.0061 0.0301
Loa Loa (eye worm) alpha-tubulin 0.0283 0.0826 0.8704
Mycobacterium ulcerans oxidoreductase 0.0084 0.0225 0.0546
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Onchocerca volvulus 0.0276 0.0804 0.0803
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0076 0.0225
Loa Loa (eye worm) hypothetical protein 0.0084 0.0225 0.2369
Brugia malayi Patched family protein 0.0013 0.0008 0.001
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0109 0.1151
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0213 0.2568
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0225 0.0828
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0494 0.5977
Leishmania major delta tubulin, putative 0.0066 0.017 0.0624
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.0454 0.0625
Loa Loa (eye worm) tubulin beta-2A chain 0.0152 0.0431 0.4536
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.056 0.2753
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.0728 0.7671
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0375 0.0486
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0207 0.0597 0.7229
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.0909
Toxoplasma gondii patched family protein 0.0013 0.0008 0.0026
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0013 0.0017
Schistosoma mansoni tyrosinase precursor 0.0276 0.0804 0.3953
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0276 0.0804 0.1107
Entamoeba histolytica tubulin gamma chain 0.0152 0.0431 0.5208
Giardia lamblia Delta tubulin 0.0066 0.017 0.0513
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.017 0.2048
Brugia malayi Furin-like cysteine rich region family protein 0.0145 0.0407 0.056
Loa Loa (eye worm) hypothetical protein 0.0051 0.0123 0.1295
Brugia malayi beta-tubulin, identical 0.0152 0.0431 0.0592
Loa Loa (eye worm) tubulin alpha-2 chain 0.0283 0.0826 0.8704
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Schistosoma mansoni ran 0.0022 0.0037 0.0179
Plasmodium falciparum protoporphyrinogen oxidase 0.0084 0.0225 0.0828
Leishmania major beta tubulin 0.0152 0.0431 0.1587
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0123 0.0605
Echinococcus multilocularis tubulin alpha chain 0.0283 0.0826 0.107
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0319
Brugia malayi protein C24B5.3 0.0013 0.0008 0.001
Echinococcus multilocularis cpg binding protein 0.0031 0.0063 0.0082
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0213 0.2568
Trypanosoma brucei tubulin gamma chain 0.0152 0.0431 0.1488
Brugia malayi hypothetical protein 0.0013 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.034
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0008 0.0041
Brugia malayi Tubulin beta chain 0.0066 0.017 0.0233
Trypanosoma brucei epsilon tubulin 0.0152 0.0431 0.1488
Brugia malayi RNA, U transporter 1 0.0086 0.0231 0.0317
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0032 0.0383
Echinococcus multilocularis tubulin epsilon chain 0.0152 0.0431 0.0558
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.008
Loa Loa (eye worm) beta-tubulin 0.0152 0.0431 0.4536
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0412 0.1518
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0027 0.0079
Onchocerca volvulus 0.0013 0.0008 0.0007
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0103
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0084 0.0109
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0051 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0051 0.0185
Loa Loa (eye worm) tubulin beta chain 0.0066 0.017 0.1788
Echinococcus granulosus dnaJ subfamily B 0.0416 0.1229 0.6045
Brugia malayi hypothetical protein 0.0013 0.0008 0.001
Trypanosoma cruzi zeta tubulin, putative 0.0066 0.017 0.0513
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0044 0.0524
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0648 0.1938
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0001 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0301 0.0414
Loa Loa (eye worm) hypothetical protein 0.0102 0.0278 0.2933
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0061 0.0108
Onchocerca volvulus 0.0035 0.0076 0.0075
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.005 0.0181
Echinococcus granulosus Protein patched homolog 1 0.0089 0.0239 0.1176
Schistosoma mansoni tyrosine kinase 0.0077 0.0202 0.0991

Activities

Activity type Activity value Assay description Source Reference
Kinact (binding) = 0.28 /mM/min Inhibition of human recombinant AChE after 6 mins by Ellman assay ChEMBL. 22738634
Kinact (binding) = 9.8 /mM/min Inhibition of Anopheles gambiae AChE expressed in Escherichia coli after 6 mins by Ellman assay ChEMBL. 22738634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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