Detailed information for compound 1670069

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 206.324 | Formula: C14H22O
  • H donors: 0 H acceptors: 1 LogP: 3.78 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=C[C@@H]2[C@@](CC1)(C)[C@H](CC2)C(C)C
  • InChi: 1S/C14H22O/c1-10(2)13-7-5-11-4-6-12(15)8-9-14(11,13)3/h4,6,10-11,13H,5,7-9H2,1-3H3/t11-,13+,14-/m0/s1
  • InChiKey: VRUKHLDBKYKEEU-YUTCNCBUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0051 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Loa Loa (eye worm) jmjC domain-containing protein 0.0195 0.0717 0.3397
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0134 0.2314
Loa Loa (eye worm) hypothetical protein 0.0103 0.0314 0.1467
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Brugia malayi Bromodomain containing protein 0.0105 0.0323 0.1544
Loa Loa (eye worm) hypothetical protein 0.0097 0.0288 0.1342
Schistosoma mansoni ap endonuclease 0.0045 0.0056 0.0056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0128 0.3429
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0008 0.0008
Schistosoma mansoni protein phosphatase 2C 0.005 0.0079 0.0079
Brugia malayi isocitrate dehydrogenase 0.0034 0.0009 0.0044
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0156 0.0547 0.0547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.012 0.0389 0.038
Loa Loa (eye worm) hypothetical protein 0.0108 0.0335 0.1568
Trypanosoma cruzi ISWI complex protein 0.0051 0.0085 0.1406
Echinococcus multilocularis phd:f box containing protein 0.005 0.0079 0.0071
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0045 0.0056 0.0182
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.0388 0.038
Brugia malayi jmjC domain containing protein 0.0195 0.0717 0.3424
Plasmodium falciparum basic transcription factor 3b, putative 0.0117 0.0374 0.1437
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0134 0.2314
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0316 0.1507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0045 0.0056 0.1018
Schistosoma mansoni tar DNA-binding protein 0.015 0.0519 0.0519
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.005 0.0079 0.13
Echinococcus granulosus lysosomal alpha glucosidase 0.0191 0.07 0.0692
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0009 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0123 0.0186
Entamoeba histolytica hypothetical protein 0.0117 0.0374 0.0797
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0613 0.2555 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0201 0.0745 0.353
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0045 0.0056 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0039 0.0031 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0079 0.0339
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.0066 0.0314
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0156 0.0547 0.0539
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0009 0.0001
Echinococcus multilocularis muscleblind protein 0.0175 0.063 0.0622
Brugia malayi hypothetical protein 0.0508 0.2094 1
Echinococcus multilocularis transcription factor btf3 0.0117 0.0374 0.0366
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0009 0.0044
Echinococcus granulosus fetal alzheimer antigen falz 0.0077 0.0198 0.019
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0051 0.0043
Echinococcus multilocularis SAM and MBT domain containing protein 0.0159 0.0561 0.0553
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0045 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0175 0.063 0.2982
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.001 0.0002
Echinococcus multilocularis histone acetyltransferase MYST2 0.0181 0.0658 0.065
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0123 0.2244
Brugia malayi Bromodomain containing protein 0.0252 0.0969 0.4629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0108 0.0336 0.0328
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0009 0.0001
Schistosoma mansoni transcription factor btf3 0.0117 0.0374 0.0374
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0123 0.2111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Plasmodium falciparum JmjC domain-containing protein, putative 0.005 0.0079 0.0281
Brugia malayi Glycosyl hydrolases family 31 protein 0.0191 0.07 0.3344
Echinococcus granulosus transcription factor Dp 1 0.009 0.0258 0.0249
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0637 0.2662 0.2655
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0008 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0097 0.0288 0.1102
Leishmania major cathepsin L-like protease 0.0062 0.0134 0.2314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0008 0.0041
Schistosoma mansoni tar DNA-binding protein 0.015 0.0519 0.0519
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.0388 0.038
Schistosoma mansoni lipoxygenase 0.0054 0.0097 0.0097
Brugia malayi ecdysteroid receptor 0.0034 0.0008 0.0041
Echinococcus granulosus JmjC domain containing protein 4 0.005 0.0079 0.0071
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0181 0.0658 0.065
Brugia malayi PHD-finger family protein 0.0085 0.0233 0.1113
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0134 0.2314
Echinococcus granulosus histone acetyltransferase MYST2 0.0181 0.0658 0.065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Brugia malayi TAR-binding protein 0.015 0.0519 0.2479
Toxoplasma gondii exonuclease III APE 0.0045 0.0056 0.1489
Brugia malayi Latrophilin receptor protein 2 0.0034 0.001 0.005
Loa Loa (eye worm) hypothetical protein 0.0103 0.0314 0.1467
Schistosoma mansoni phd/f-box containing protein 0.005 0.0079 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0108 0.0336 0.0328
Onchocerca volvulus 0.0159 0.0561 0.4905
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0077 0.0198 0.0198
Schistosoma mansoni alpha-glucosidase 0.0164 0.0583 0.0583
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0613 0.2555 1
Leishmania major hypothetical protein, conserved 0.0051 0.0085 0.1406
Brugia malayi hypothetical protein 0.0103 0.0314 0.1501
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0123 0.2111
Loa Loa (eye worm) hypothetical protein 0.029 0.1135 0.5401
Schistosoma mansoni alpha-glucosidase 0.0164 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.029 0.1135 0.5401
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0046 0.1241
Echinococcus multilocularis polycomb protein SCMH1 0.0159 0.0561 0.0553
Schistosoma mansoni jumonji/arid domain-containing protein 0.0195 0.0717 0.0717
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0123 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Echinococcus granulosus peregrin 0.0105 0.0323 0.0315
Echinococcus multilocularis transcription factor Dp 1 0.009 0.0258 0.0249
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0156 0.0547 0.2582
Loa Loa (eye worm) MH2 domain-containing protein 0.0399 0.1614 0.7701
Brugia malayi MH2 domain containing protein 0.0399 0.1614 0.771
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0079 0.0339
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0977 0.4155 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0113 0.0113
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0374 0.0797
Treponema pallidum fructose-bisphosphate aldolase 0.0977 0.4155 1
Entamoeba histolytica hypothetical protein 0.012 0.0389 0.0833
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.07 0.0692
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0088 0.0249 0.1153
Schistosoma mansoni tar DNA-binding protein 0.015 0.0519 0.0519
Echinococcus granulosus jumonji domain containing 1A 0.005 0.0079 0.0071
Trypanosoma brucei protein kinase, putative 0.006 0.0123 0.2244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0108 0.0336 0.1604
Entamoeba histolytica transcription factor BTF3, putative 0.0117 0.0374 0.0797
Schistosoma mansoni hypothetical protein 0.012 0.0389 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0008 0.0041
Trypanosoma brucei ISWI complex protein 0.0051 0.0085 0.155
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0009 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0123 0.0186
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0097 0.0088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0108 0.0336 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0374 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0008 0.0041
Trichomonas vaginalis ap endonuclease, putative 0.0045 0.0056 0.0023
Leishmania major basic transcription factor 3a, putative 0.0117 0.0374 0.6781
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0123 0.0186
Echinococcus granulosus zinc finger protein 0.0067 0.0155 0.0146
Brugia malayi Muscleblind-like protein 0.0175 0.063 0.301
Schistosoma mansoni microtubule-associated protein tau 0.2306 1 1
Loa Loa (eye worm) mbt repeat family protein 0.0159 0.0561 0.2649
Loa Loa (eye worm) hypothetical protein 0.005 0.0079 0.0339
Echinococcus multilocularis microtubule associated protein 2 0.2306 1 1
Schistosoma mansoni ap endonuclease 0.0045 0.0056 0.0056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0008 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0104 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0097 0.0288 0.0288
Echinococcus multilocularis geminin 0.0566 0.235 0.2343
Schistosoma mansoni jumonji domain containing protein 0.005 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.009 0.0256 0.1188
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0045 0.0056 0.0189
Echinococcus granulosus muscleblind protein 0.0175 0.063 0.0622
Echinococcus granulosus lysine specific demethylase 5A 0.0195 0.0717 0.0709
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0008 0.0041
Schistosoma mansoni zinc finger protein 0.0067 0.0155 0.0155
Trypanosoma cruzi transcription factor btf3, putative 0.0117 0.0374 0.6781
Trypanosoma brucei transcription factor BTF3, putative 0.0117 0.0374 0.6835
Echinococcus multilocularis musashi 0.009 0.0256 0.0248
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0613 0.2555 1
Schistosoma mansoni coup transcription factor 0.0034 0.0008 0.0008
Schistosoma mansoni transcription factor LCR-F1 0.012 0.0389 0.0389
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.1615 0.1607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0201 0.0744 0.0736
Echinococcus granulosus dnaJ subfamily B 0.0399 0.1615 0.1607
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0123 0.0114
Toxoplasma gondii PHD-finger domain-containing protein 0.0097 0.0288 0.7716
Loa Loa (eye worm) hypothetical protein 0.0159 0.0561 0.2649
Echinococcus granulosus lamin 0.009 0.0256 0.0248
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0057 0.0111 0.0102
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0191 0.07 0.3317
Schistosoma mansoni lamin 0.009 0.0256 0.0256
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0156 0.0547 0.1218
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0181 0.0658 0.065
Schistosoma mansoni jumonji domain containing protein 0.0322 0.1278 0.1278
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0156 0.0547 0.0539
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0181 0.0658 0.3142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0156 0.0547 1
Brugia malayi PHD-finger family protein 0.004 0.0035 0.0168
Loa Loa (eye worm) hypothetical protein 0.0175 0.063 0.2982
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.005 0.0079 0.1447
Echinococcus granulosus jumonji domain containing protein 0.0136 0.0456 0.0448
Loa Loa (eye worm) hypothetical protein 0.0144 0.0494 0.2327
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0009 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0008 0.0041
Loa Loa (eye worm) PHD-finger family protein 0.0069 0.0163 0.0742
Echinococcus multilocularis cpg binding protein 0.0036 0.0018 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0113 0.0105
Schistosoma mansoni hypothetical protein 0.0074 0.0185 0.0185
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0046 0.0692
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.011 0.1873
Brugia malayi jmjC domain containing protein 0.005 0.0079 0.0378
Giardia lamblia PHD finger protein 15 0.0097 0.0288 0.0568
Echinococcus granulosus survival motor neuron protein 1 0.0508 0.2094 0.2087
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0046 0.0692
Schistosoma mansoni myelin transcription factor 1 myt1 0.0181 0.0658 0.0658
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0123 0.0164
Echinococcus multilocularis JmjC domain containing protein 4 0.005 0.0079 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.001 0.0009
Loa Loa (eye worm) bromodomain containing protein 0.0059 0.012 0.0533
Echinococcus multilocularis lamin dm0 0.009 0.0256 0.0248
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0008 0.0008
Loa Loa (eye worm) RNA binding protein 0.015 0.0519 0.2449
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0388 0.1566 0.1559
Echinococcus granulosus PHD finger protein rhinoceros 0.0097 0.0288 0.028
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0185 0.0884
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0008 0.0008
Schistosoma mansoni zinc finger protein 0.0051 0.0085 0.0085
Brugia malayi Bromodomain containing protein 0.0128 0.0423 0.2019
Entamoeba histolytica hypothetical protein 0.012 0.0389 0.0833
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0201 0.0744 0.0736
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0477 0.1958 0.7653
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.0675 0.3198
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0156 0.0547 1
Echinococcus granulosus cpg binding protein 0.0036 0.0018 0.001
Schistosoma mansoni sex comb on midleg homolog 0.0159 0.0561 0.0561
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0045 0.0056 0.0226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0108 0.0336 0.0328
Echinococcus multilocularis peregrin 0.0105 0.0323 0.0315
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0134 0.2314
Echinococcus multilocularis zinc finger protein 0.0067 0.0155 0.0146
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0114 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0108 0.0336 0.0336
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0009 0.0169
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0045 0.0056 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0051 0.0043
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0156 0.0547 1
Schistosoma mansoni hypothetical protein 0.0978 0.416 0.416
Schistosoma mansoni cpg binding protein 0.0036 0.0018 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0008 0.0041
Schistosoma mansoni alpha glucosidase 0.0042 0.0046 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0045 0.0056 0.0864
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0009 0.0007
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0075 0.1225
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0123 0.3284
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0477 0.1958 0.761
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0008 0.0041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.009 0.0256 0.1188
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0008 0.0041
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0123 0.2111
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0123 0.0548
Schistosoma mansoni intermediate filament proteins 0.009 0.0256 0.0256
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0113 0.0105
Echinococcus multilocularis lysine specific demethylase 6a 0.005 0.0079 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.001
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.005 0.0079 0.13
Onchocerca volvulus Huntingtin homolog 0.029 0.1135 1
Schistosoma mansoni phosphatidylserine receptor 0.005 0.0079 0.0079
Echinococcus granulosus methyl CpG binding domain protein 2 0.0057 0.0111 0.0102
Schistosoma mansoni methyl-cpg binding protein mbd 0.0057 0.0111 0.0111
Brugia malayi intermediate filament protein 0.009 0.0256 0.1224
Onchocerca volvulus 0.009 0.0256 0.22
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.015 0.0519 0.2449
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0008 0.0041
Loa Loa (eye worm) hypothetical protein 0.0181 0.0658 0.3114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0008 0.0041
Schistosoma mansoni tar DNA-binding protein 0.015 0.0519 0.0519
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0009 0.0247
Echinococcus granulosus phd:f box containing protein 0.005 0.0079 0.0071
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0045 0.0056 0.0864
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0388 0.1566 0.1559
Toxoplasma gondii NAC domain-containing protein 0.0117 0.0374 1
Brugia malayi beta-NAC-like protein 0.0117 0.0374 0.1785
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.017
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0977 0.4155 1
Echinococcus multilocularis muscleblind protein 1 0.0175 0.063 0.0622
Brugia malayi RNA recognition motif domain containing protein 0.015 0.0519 0.2479
Entamoeba histolytica hypothetical protein 0.012 0.0389 0.0833
Leishmania major cathepsin L-like protease 0.0062 0.0134 0.2314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.001 0.005
Brugia malayi nuclear hormone receptor 0.0034 0.0008 0.0041
Schistosoma mansoni eyes absent homolog 0.0103 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.005 0.0079 0.0339
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0008 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0008 0.0041
Brugia malayi PHD-finger family protein 0.0097 0.0288 0.1377
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0121 0.0121
Onchocerca volvulus Alhambra homolog 0.0097 0.0288 0.2485
Onchocerca volvulus 0.009 0.0256 0.22
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0374 0.0797
Schistosoma mansoni survival motor neuron protein 0.0104 0.0316 0.0316
Trypanosoma cruzi ISWI complex protein 0.0051 0.0085 0.1406
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0072 0.0345
Brugia malayi RNA binding protein 0.015 0.0519 0.2479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0108 0.0336 0.0336
Schistosoma mansoni cpg binding protein 0.0036 0.0018 0.0018
Echinococcus granulosus polycomb protein SCMH1 0.0159 0.0561 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0008 0.0041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0045 0.0056 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0008 0.0008
Echinococcus granulosus intermediate filament protein 0.009 0.0256 0.0248
Echinococcus multilocularis lysine specific demethylase 5A 0.0187 0.0682 0.0674
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0008 0.0008
Brugia malayi steroid hormone receptor 0.0034 0.0008 0.0041
Trypanosoma cruzi transcription factor btf3, putative 0.0117 0.0374 0.6781
Echinococcus granulosus GPCR family 2 0.0034 0.001 0.0002
Echinococcus granulosus transcription factor btf3 0.0117 0.0374 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0008 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0045 0.0056 0.0266
Treponema pallidum hypothetical protein 0.0613 0.2555 0.6098
Trypanosoma brucei glucosidase, putative 0.0042 0.0046 0.0848
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0008 0.0008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.005 0.0079 0.0378
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0009 0.0169
Loa Loa (eye worm) hypothetical protein 0.004 0.0035 0.0128
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0123 0.0186
Plasmodium vivax basic transcription factor 3b, putative 0.0117 0.0374 0.1437
Loa Loa (eye worm) hypothetical protein 0.0074 0.0185 0.0847
Giardia lamblia Fructose-bisphosphate aldolase 0.0977 0.4155 1
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0008 0.0008
Brugia malayi mbt repeat family protein 0.0159 0.0561 0.2679
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.012 0.0389 0.038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0113 0.0113
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0123 0.2111
Echinococcus granulosus geminin 0.0566 0.235 0.2343
Brugia malayi jmjC domain containing protein 0.0388 0.1566 0.7481
Loa Loa (eye worm) hypothetical protein 0.0236 0.0899 0.4272
Schistosoma mansoni tar DNA-binding protein 0.015 0.0519 0.0519
Brugia malayi hypothetical protein 0.029 0.1135 0.542
Schistosoma mansoni hypothetical protein 0.0566 0.235 0.235
Schistosoma mansoni methyl-cpg binding protein mbd 0.0057 0.0111 0.0111
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0159 0.0561 0.0561
Loa Loa (eye worm) transcription factor SMAD2 0.0399 0.1614 0.7701
Toxoplasma gondii PHD-finger domain-containing protein 0.0097 0.0288 0.7716
Echinococcus granulosus tar DNA binding protein 0.015 0.0519 0.0511
Echinococcus granulosus lysine specific demethylase 6a 0.005 0.0079 0.0071
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0613 0.2555 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0009 0.0001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0156 0.0547 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.005 0.0079 0.2117
Brugia malayi hypothetical protein 0.012 0.0389 0.1856
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1759 0.7594 0.7592
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0123 0.2111
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.001
Brugia malayi nuclear receptor NHR-88 0.0034 0.0008 0.0041
Plasmodium vivax JmjC domain containing protein 0.005 0.0079 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Leishmania major cathepsin L-like protease 0.0062 0.0134 0.2314
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0097 0.0088
Loa Loa (eye worm) ICD-1 protein 0.0117 0.0374 0.1752
Loa Loa (eye worm) PHD-finger family protein 0.0097 0.0288 0.1342
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0613 0.2555 1
Echinococcus granulosus lamin dm0 0.009 0.0256 0.0248
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0977 0.4155 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0459 0.2159
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0046 0.0692
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0077 0.0198 0.019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0108 0.0336 0.157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0108 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0399 0.1615 0.1615
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0046 0.0038
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0114 0.0106
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0335 0.1568
Brugia malayi jmjC domain containing protein 0.005 0.0079 0.0378
Echinococcus multilocularis tar DNA binding protein 0.015 0.0519 0.0511
Leishmania major hypothetical protein, conserved 0.005 0.0079 0.13
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0123 0.2111
Brugia malayi mbt repeat family protein 0.0159 0.0561 0.2679
Schistosoma mansoni sex comb on midleg homolog 0.0159 0.0561 0.0561
Onchocerca volvulus 0.0111 0.0346 0.2996
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0072 0.0306
Echinococcus multilocularis jumonji domain containing protein 0.0136 0.0456 0.0448
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.005 0.0079 0.0079
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0045 0.0056 0.0864
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0159 0.0561 0.4905
Loa Loa (eye worm) hypothetical protein 0.0058 0.0113 0.0502
Onchocerca volvulus Huntingtin homolog 0.029 0.1135 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0191 0.07 0.0692
Echinococcus multilocularis PHD finger protein rhinoceros 0.0097 0.0288 0.028
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0097 0.0288 0.0288
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.001 0.0002
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.005 0.0079 0.2117
Schistosoma mansoni hypothetical protein 0.0034 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0044 0.017
Loa Loa (eye worm) intermediate filament protein 0.009 0.0256 0.1188
Entamoeba histolytica hypothetical protein 0.012 0.0389 0.0833
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0335 0.1602
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0009 0.0247
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0156 0.0547 0.2612
Echinococcus multilocularis survival motor neuron protein 1 0.0508 0.2094 0.2087
Trichomonas vaginalis ap endonuclease, putative 0.0045 0.0056 0.0023
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0123 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0008 0.0041
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0009 0.0003
Schistosoma mansoni hypothetical protein 0.0051 0.0085 0.0085
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0046 0.0182
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.001 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Schistosoma mansoni lamin 0.009 0.0256 0.0256
Echinococcus multilocularis jumonji domain containing 1A 0.005 0.0079 0.0071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0128 0.0424 0.1992
Schistosoma mansoni hypothetical protein 0.0566 0.235 0.235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0134 0.2444
Onchocerca volvulus 0.0104 0.0316 0.2727
Loa Loa (eye worm) jmjC domain-containing protein 0.005 0.0079 0.0339
Schistosoma mansoni jumonji/arid domain-containing protein 0.0195 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0034 0.001 0.0009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0046 0.0222
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0045 0.0056 0.0189
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0123 0.0114
Echinococcus granulosus SAM and MBT domain containing protein 0.0159 0.0561 0.0553
Loa Loa (eye worm) hypothetical protein 0.0508 0.2094 1
Loa Loa (eye worm) MBCTL1 0.0181 0.0658 0.3114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0008 0.0041
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0046 0.0038
Brugia malayi MAP kinase sur-1 0.006 0.0123 0.0586
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0335 0.1602
Echinococcus multilocularis GPCR, family 2 0.0034 0.001 0.0002
Echinococcus multilocularis lamin 0.009 0.0256 0.0248
Plasmodium falciparum phd finger protein, putative 0.0097 0.0288 0.1102
Brugia malayi jmjC domain containing protein 0.005 0.0079 0.0378
Schistosoma mansoni hypothetical protein 0.0069 0.0163 0.0163
Loa Loa (eye worm) TAR-binding protein 0.015 0.0519 0.2449
Schistosoma mansoni bromodomain containing protein 0.0213 0.0797 0.0797
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0637 0.2662 0.2655
Brugia malayi Intermediate filament tail domain containing protein 0.009 0.0256 0.1224

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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