Detailed information for compound 1695011

Basic information

Technical information
  • TDR Targets ID: 1695011
  • Name: 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(3 -oxobutan-2-yloxy)benzamide hydrochloride
  • MW: 392.321 | Formula: C17H27Cl2N3O3
  • H donors: 2 H acceptors: 2 LogP: 2.84 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)c1cc(Cl)c(cc1OC(C(=O)C)C)N)CC.Cl
  • InChi: 1S/C17H26ClN3O3.ClH/c1-5-21(6-2)8-7-20-17(23)13-9-14(18)15(19)10-16(13)24-12(4)11(3)22;/h9-10,12H,5-8,19H2,1-4H3,(H,20,23);1H
  • InChiKey: CUTCEGXKJDBAFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(1-methyl-2-oxo-propoxy)benzamide hydrochloride
  • 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(1-methyl-2-oxopropoxy)benzamide hydrochloride
  • 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(2-keto-1-methyl-propoxy)benzamide hydrochloride
  • 102670-59-7
  • 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-((1-methylacetonyl)oxy)benzamide monohydrochloride
  • BATANOPRIDE HYDROCHLORIDE
  • BMY-25801-01
  • Batanopride hydrochloride [USAN]
  • Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(1-methyl-2-oxopropoxy)-, monohydrochloride
  • BMY-25801 free base
  • Batanopride hydrochloride (USAN)
  • D03060

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0272 0.0324 0.2396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.0456 0.4333
Loa Loa (eye worm) calcium channel 0.0035 0.0025 0.0181
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0007 0.0007
Toxoplasma gondii target of rapamycin (TOR), putative 0.0688 0.085 1
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0028 0.0075
Schistosoma mansoni lamin 0.0029 0.0017 0.0113
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0882 0.8437
Schistosoma mansoni lamin 0.0029 0.0017 0.0113
Brugia malayi hypothetical protein 0.0039 0.003 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7884
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0009 0.0064
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0095 0.01 0.01
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.0189 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0073 0.0637
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0365 0.0442 0.4196
Echinococcus multilocularis tumor protein p63 0.037 0.0449 0.0449
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.0466
Onchocerca volvulus 0.0056 0.0051 0.1193
Schistosoma mansoni hypothetical protein 0.0271 0.0323 0.2122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0713 0.0882 0.8437
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0025 0.0161
Echinococcus multilocularis expressed conserved protein 0.0089 0.0093 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0164 0.5649
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0017 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0145 0.0164 0.1076
Plasmodium falciparum casein kinase 2, alpha subunit 0.015 0.017 0.6121
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0352 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0516 0.0633 0.4674
Brugia malayi Serotonin receptor 0.0514 0.063 0.6038
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0618 0.0762 0.0762
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.021 0.0246 0.1815
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0145 0.0164 0.0466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0139
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0232 0.0274 0.2022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Brugia malayi Protein kinase domain containing protein 0.0352 0.0425 0.4075
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0232 0.0274 0.2577
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0365 0.0442 0.4972
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.0104 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Giardia lamblia Hypothetical protein 0.0145 0.0164 0.1661
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0051 0.0045 0.0368
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0007 0.0007
Brugia malayi PXA domain containing protein 0.0023 0.0009 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.2756 0.3467 1
Echinococcus multilocularis high voltage activated calcium channel beta 0.0095 0.01 0.01
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0051 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0164 0.1515
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0031 0.0203
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0145 0.0164 0.1076
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0232 0.0274 0.2577
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0702 0.0869 0.2501
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0025 0.0182
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0164 0.1924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7884
Toxoplasma gondii ck2 beta subunit 0.004 0.0031 0.036
Toxoplasma gondii hypothetical protein 0.0036 0.0025 0.0297
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.002 0.002
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0021 0.0241
Echinococcus granulosus expressed conserved protein 0.005 0.0043 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0021 0.0245
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0232 0.0274 0.2577
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0007 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0131 0.0131
Echinococcus granulosus lamin 0.0029 0.0017 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0145 0.0164 0.1515
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0007 0.0044
Entamoeba histolytica protein kinase rad3, putative 0.0376 0.0456 0.4333
Brugia malayi hypothetical protein 0.005 0.0043 0.0409
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0087 0.009 0.0952
Onchocerca volvulus 0.011 0.0119 0.2805
Brugia malayi hypothetical protein 0.0021 0.0007 0.0064
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0009 0.0027
Plasmodium falciparum glycogen synthase kinase 3 0.0056 0.0051 0.1675
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0417 0.0508 0.3337
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0232 0.0274 0.0274
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0051 0.0045 0.0123
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0131 0.1197
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0713 0.0882 0.0882
Echinococcus granulosus bloom syndrome protein 0.0023 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0246 0.1615
Brugia malayi phosphofructokinase 0.0119 0.0131 0.1253
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0505 0.0618 0.694
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0352 0.0425 0.0425
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0007 0.0064
Schistosoma mansoni survival motor neuron protein 0.0105 0.0113 0.0744
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0131 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0637 0.0786 0.7517
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0376 0.0456 0.0456
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0074
Giardia lamblia Phosphatidylinositol 4-kinase 0.0145 0.0164 0.1661
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0376 0.0456 0.131
Entamoeba histolytica protein kinase domain containing protein 0.015 0.017 0.1574
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0161 0.0184 0.0525
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0708 0.0876 0.8381
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Entamoeba histolytica hypothetical protein 0.0708 0.0876 0.8381
Loa Loa (eye worm) hypothetical protein 0.005 0.0043 0.0316
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0007 0.0007
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0037 0.0242
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0841 0.1044 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0531 0.506
Plasmodium vivax hypothetical protein 0.0145 0.0164 0.5649
Brugia malayi 6-phosphofructokinase 0.0119 0.0131 0.1253
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0659 0.0814 0.9223
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Leishmania major phosphatidylinositol 3-kinase, putative 0.0647 0.0799 0.2184
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0025 0.0161
Echinococcus multilocularis serine protein kinase ATM 0.0392 0.0476 0.0476
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.022 0.0258 0.0739
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.0051 0.0051
Trypanosoma cruzi casein kinase II, putative 0.015 0.017 0.0484
Toxoplasma gondii hypothetical protein 0.0073 0.0073 0.0853
Toxoplasma gondii GAF domain-containing protein 0.0036 0.0025 0.0297
Loa Loa (eye worm) phosphatidylinositol 3 0.0659 0.0814 0.601
Brugia malayi PXA domain containing protein 0.0023 0.0009 0.0082
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0131 0.7613
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.0466
Schistosoma mansoni hypothetical protein 0.0184 0.0213 0.14
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0087 0.009 0.009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.003 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.0311 0.2299
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0278 0.0332 0.3612
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.0784
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0713 0.0882 0.2538
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0013
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0031 0.0078
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0164 1
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0713 0.0882 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0021 0.0021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.0266 0.1966
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0025 0.0025
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0082 0.0082
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0007 0.0064
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0007 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0507 0.4823
Toxoplasma gondii CMGC kinase, CK2 family 0.015 0.017 0.1997
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0003 0.0021
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Brugia malayi 6-phosphofructokinase 0.0119 0.0131 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0074
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Trypanosoma cruzi polo-like protein kinase, putative 0.021 0.0246 0.0703
Brugia malayi intermediate filament protein 0.0029 0.0017 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0145 0.0164 0.0164
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0621 0.0766 0.7334
Echinococcus multilocularis lamin 0.0029 0.0017 0.0017
Leishmania major cytochrome p450-like protein 0.0021 0.0007 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0145 0.0164 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0247 0.0293 0.0838
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.0513 0.4885
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0392 0.0476 0.5365
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.000000005167 0.000000033943
Loa Loa (eye worm) hypothetical protein 0.0145 0.0164 0.1209
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0025 0.0161
Echinococcus multilocularis expressed protein 0.0409 0.0498 0.0498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Echinococcus multilocularis geminin 0.0184 0.0213 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0713 0.0882 0.8437
Brugia malayi bHLH-PAS transcription factor 0.0039 0.003 0.0287
Leishmania major phosphatidylinositol kinase, putative 0.0145 0.0164 0.0443
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.005 0.0043 0.035
Giardia lamblia Kinase, PLK 0.021 0.0246 0.2614
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Echinococcus granulosus tumor protein p63 0.037 0.0449 0.0449
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0392 0.0476 0.1368
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0021 0.0557
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.0104 0.0104
Brugia malayi Protein kinase domain containing protein 0.0019 0.0005 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.0539 0.5131
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0095 0.01 0.0659
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0131 0.0859
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0007 0.0044
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0051 0.0375
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0007 0.0007
Brugia malayi hypothetical protein 0.005 0.0043 0.0409
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0021 0.0136
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0056 0.0051 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0352 0.0425 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1219 0.1522 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0 0.0001
Trypanosoma brucei polo-like protein kinase 0.021 0.0246 0.2731
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0306 0.2884
Schistosoma mansoni hypothetical protein 0.0056 0.0051 0.0336
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0066
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0007 0.0064
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0049 0.032
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0365 0.0442 0.1269
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0007 0.0044
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0073 0.0637
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0049 0.0359
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.003 0.0197
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0416 0.0507 0.5961
Schistosoma mansoni hypothetical protein 0.0184 0.0213 0.14
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0145 0.0164 0.5892
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0011 0.0084
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0702 0.0869 0.0869
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.0051 0.0051
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0164 0.1924
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0087 0.009 0.0952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0021 0.0157
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0131 0.1197
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0152 0.1458
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0031 0.0082
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0125 0.0139 0.1272
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0232 0.0274 1
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0131 0.0352
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0046 0.0378
Brugia malayi Casein kinase II, alpha chain 0.015 0.017 0.1628
Loa Loa (eye worm) hypothetical protein 0.011 0.0119 0.0881
Echinococcus multilocularis protein kinase shaggy 0.0056 0.0051 0.0051
Echinococcus multilocularis cyclin dependent kinase 19 0.0147 0.0166 0.0166
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.1793
Onchocerca volvulus 0.0029 0.0017 0.0403
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0074 0.0074 0.3492
Brugia malayi follicle stimulating hormone receptor 0.0262 0.0311 0.2983
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0007 0.0044
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Leishmania major hypothetical protein, conserved 0.2902 0.3651 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0145 0.0164 0.1209
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0232 0.0274 0.3221
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0007 0.0007
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0025 0.1497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0271 0.0323 0.0323
Echinococcus multilocularis lamin dm0 0.0029 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0507 0.4823
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.5649
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.005 0.0043 0.0043
Loa Loa (eye worm) phosphatidylinositol 3 0.022 0.0258 0.1906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7884
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0618 0.0762 0.563
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0233
Brugia malayi FAT domain containing protein 0.0271 0.0323 0.3094
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0145 0.0164 0.5649
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0007 0.0007
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0021 0.5
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0131 0.1415
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0082 0.0082
Toxoplasma gondii FATC domain-containing protein 0.0392 0.0476 0.5603
Brugia malayi hypothetical protein 0.0179 0.0206 0.1977
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0233
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0048 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Schistosoma mansoni protein kinase 0.015 0.017 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0882 0.8437
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0114 0.1031
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0017 0.0164
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.0051 0.0333
Brugia malayi hypothetical protein 0.0516 0.0633 0.6064
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0051 0.0045 0.0368
Trypanosoma brucei protein kinase, putative 0.0056 0.0051 0.0501
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0196 0.0228 0.2183
Schistosoma mansoni hypothetical protein 0.0089 0.0093 0.0612
Loa Loa (eye worm) hypothetical protein 0.0373 0.0451 0.3333
Loa Loa (eye worm) hypothetical protein 0.0247 0.0293 0.2161
Schistosoma mansoni fkbp-rapamycin associated protein 0.0376 0.0456 0.2996
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0104 0.0681
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.3052
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0145 0.0164 0.5892
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Echinococcus granulosus intermediate filament protein 0.0029 0.0017 0.0017
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0051
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0841 0.1044 1
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.003 0.003
Trypanosoma brucei Casein kinase II 0.015 0.017 0.1863
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0713 0.0882 0.5793
Echinococcus granulosus high voltage activated calcium channel beta 0.0095 0.01 0.01
Brugia malayi Csnk2b protein 0.004 0.0031 0.0296
Leishmania major phosphatidylinositol 3-kinase, putative 0.0232 0.0274 0.0744
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0052 0.0046 0.0341
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0131 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.0564 0.5374
Echinococcus multilocularis musashi 0.0029 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0841 0.1044 1
Schistosoma mansoni serine/threonine protein kinase 0.0352 0.0425 0.2795
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0232 0.0274 0.2577
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0087 0.009 0.0254
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.0744
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0164 0.1924
Echinococcus granulosus casein kinase ii subunit alpha 0.015 0.017 0.017
Loa Loa (eye worm) RecQ helicase 0.0023 0.0009 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0164 0.1569
Entamoeba histolytica protein kinase, putative 0.0056 0.0051 0.0425
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0232 0.0274 0.0274
Brugia malayi Death domain containing protein 0.0016 0.000000005167 0.000000049498
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0702 0.0869 0.5707
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Schistosoma mansoni single-minded 0.0053 0.0048 0.0312
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0713 0.0882 0.2411
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0139
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Loa Loa (eye worm) hypothetical protein 0.0136 0.0152 0.1124
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0007 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0376 0.0456 0.4369
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0125 0.0139 0.1272
Echinococcus granulosus geminin 0.0184 0.0213 0.0213
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.7921 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.005 0.0043 0.035
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0145 0.0164 0.1076
Brugia malayi hypothetical protein 0.011 0.0119 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0189 0.176
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0125 0.0139 0.1272
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0181
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.005 0.0043 0.0412
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0122
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0011 0.0084
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0388 0.0471 0.4476
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0272 0.2562
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0713 0.0882 0.2538
Brugia malayi Pre-SET motif family protein 0.0226 0.0266 0.255
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0673 0.0831 0.7947
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0365 0.0442 0.4233
Brugia malayi Pre-SET motif family protein 0.0032 0.0021 0.0202
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0232 0.0274 0.1799
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1219 0.1522 0.1522
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0046 0.0378
Giardia lamblia GTOR 0.0713 0.0882 1
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0051 0.0348
Loa Loa (eye worm) hypothetical protein 0.0036 0.0025 0.0188
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0352 0.0425 0.4075
Entamoeba histolytica hypothetical protein 0.0145 0.0164 0.1515
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0376 0.0456 0.0456
Giardia lamblia Casein kinase II beta chain 0.004 0.0031 0.0117
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0066
Plasmodium falciparum casein kinase II beta chain 0.004 0.0031 0.0933
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0007 0.0007
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0051 0.0348
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0145 0.0164 0.1515
Brugia malayi intracellular kinase 0.0056 0.0051 0.0486
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0007 0.0007
Plasmodium falciparum casein kinase II beta chain 0.004 0.0031 0.0933
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.005 0.0043 0.035
Brugia malayi SH2 domain containing protein 0.0373 0.0451 0.4324
Loa Loa (eye worm) phosphatidylinositol 3 0.1086 0.1354 1
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0007 0.0007
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0031 0.0725
Onchocerca volvulus 0.0258 0.0306 0.7191
Loa Loa (eye worm) hypothetical protein 0.0179 0.0206 0.1524
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0166 0.1088
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0021 0.0021
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0007 0.0007
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0136 0.0152 0.1
Brugia malayi M-phase phosphoprotein, mpp8 0.011 0.0119 0.1143
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0007 0.0007
Onchocerca volvulus Serine\/threonine kinase homolog 0.021 0.0246 0.5778
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0074 0.0074 0.5397
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0271 0.0323 0.0323
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0007 0.0007
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0145 0.0164 0.1793
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Loa Loa (eye worm) Csnk2b protein 0.004 0.0031 0.0228
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.011 0.0119 0.0882
Brugia malayi hypothetical protein 0.0021 0.0007 0.0064
Entamoeba histolytica hypothetical protein 0.0145 0.0164 0.1515
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0013
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0232 0.0274 0.2624
Echinococcus granulosus lamin dm0 0.0029 0.0017 0.0017
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0087 0.009 0.0254
Entamoeba histolytica casein kinase, putative 0.015 0.017 0.1574
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0007 0.0007
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.0425
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0693 0.0856 0.2341
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.015 0.017 0.1255
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0139 0.1272
Trypanosoma cruzi target of rapamycin kinase 3 0.0693 0.0856 0.2465
Brugia malayi serine/threonine-protein kinase plk-2 0.021 0.0246 0.2355
Onchocerca volvulus 0.0029 0.0017 0.0403
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0131 0.7613
Echinococcus multilocularis survival motor neuron protein 1 0.0516 0.0633 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0673 0.0831 0.7947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0882 0.8437
Echinococcus granulosus serine protein kinase ATM 0.0392 0.0476 0.0476
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0009 0.009
Brugia malayi PAS domain containing protein 0.0053 0.0048 0.0455
Onchocerca volvulus 0.0045 0.0037 0.0865
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0436 0.0532 0.6004
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0087 0.009 0.0593
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0021 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Mycobacterium ulcerans putative regulatory protein 0.0039 0.003 0.1861
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0025 0.1497
Echinococcus granulosus serine:threonine protein kinase PLK1 0.021 0.0246 0.0246
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0031 0.0725
Leishmania major casein kinase II, putative 0.015 0.017 0.046
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0087 0.009 0.0254
Brugia malayi Cytochrome P450 family protein 0.0033 0.0021 0.0203
Onchocerca volvulus 0.0105 0.0113 0.2662
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0127
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Entamoeba histolytica serine/threonine protein kinase, putative 0.021 0.0246 0.2306
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0031 0.0031
Brugia malayi Uncoordinated protein 44 0.0016 0.000000005167 0.000000049498
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0232 0.0274 0.3221
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0841 0.1044 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.005 0.0043 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0392 0.0476 0.4563
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.015 0.017 0.5893
Entamoeba histolytica hypothetical protein 0.0392 0.0476 0.4528
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0105 0.0113 0.0744
Onchocerca volvulus 0.0145 0.0164 0.385
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.021 0.0246 0.0668
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0025 0.0025
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0021 0.0136
Loa Loa (eye worm) phosphatidylinositol 3 0.0713 0.0882 0.6511
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Leishmania major phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.0443
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0232 0.0274 1
Loa Loa (eye worm) gastrulation defective protein 1 0.0143 0.0161 0.1188
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0087 0.009 0.009
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0637 0.0786 0.7517
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0011 0.0109
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1219 0.1522 0.1522
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0074
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0618 0.0762 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Plasmodium vivax SET domain protein, putative 0.0032 0.0021 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Giardia lamblia Kinase, CMGC CK2 0.015 0.017 0.1732
Plasmodium vivax glycogen synthase kinase 3, putative 0.0056 0.0051 0.1183
Brugia malayi hypoxia-induced factor 1 0.0165 0.0189 0.1809
Loa Loa (eye worm) hypothetical protein 0.0376 0.0456 0.3367
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0232 0.0274 0.2577
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0164 0.1515
Brugia malayi Protein kinase domain containing protein 0.0147 0.0166 0.1586
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0659 0.0814 0.2224
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0026
Schistosoma mansoni hypothetical protein 0.0039 0.003 0.0197
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0025 0.0025
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0131 0.0966
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Loa Loa (eye worm) hypothetical protein 0.0416 0.0507 0.3742
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0702 0.0869 0.0869
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0113 0.1085
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0021 0.0241
Echinococcus multilocularis casein kinase ii subunit alpha 0.015 0.017 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0702 0.0869 0.8322
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0232 0.0274 0.0274
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0365 0.0442 0.4196
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0388 0.0471 0.4476
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0392 0.0476 0.4528
Echinococcus granulosus survival motor neuron protein 1 0.0516 0.0633 0.0633
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0185 0.0215 0.2374
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0131 0.1197
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0147 0.0166 0.1222
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0841 0.1044 1
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0114 0.1031
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0031 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.0272 0.2562
Onchocerca volvulus 0.0054 0.0049 0.1143
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0145 0.0164 0.1515
Loa Loa (eye worm) hypothetical protein 0.0271 0.0323 0.2385
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0713 0.0882 0.8447
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0196 0.0228 0.1683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0713 0.0882 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0505 0.4803
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0696 0.086 0.8229
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0232 0.0274 0.1799
Toxoplasma gondii hypothetical protein 0.0036 0.0025 0.0297
Echinococcus multilocularis Zinc finger, PHD finger 0.0232 0.0274 0.0274
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0131 0.0966
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0392 0.0476 0.3129
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0025 0.0235
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0031 0.0273
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0051 0.0425
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0352 0.0425 0.3141
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0007 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0271 0.0323 0.305
Leishmania major hypothetical protein, conserved 0.0038 0.0028 0.0071
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0713 0.0882 0.2411
Onchocerca volvulus 0.0145 0.0164 0.385
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Leishmania major hypothetical protein, unknown function 0.0145 0.0164 0.0443
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0145 0.0164 0.1076
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0647 0.0799 0.9053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.0028 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0814 0.7782
Echinococcus granulosus expressed protein 0.0409 0.0498 0.0498
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0378 0.0458 0.4392
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0164 0.1569
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0031 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Onchocerca volvulus 0.011 0.0119 0.2805
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Onchocerca volvulus 0.0039 0.003 0.0705
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0051 0.0375
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0007 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0507 0.4823
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0352 0.0425 0.3141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0009 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0841 0.1044 0.3006
Echinococcus multilocularis expressed conserved protein 0.005 0.0043 0.0043
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0365 0.0442 0.4196
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0031 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Echinococcus multilocularis 0.0145 0.0164 0.0164
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.0784
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0889 0.1104 0.1104
Schistosoma mansoni kinase 0.0108 0.0117 0.0769
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0021 0.0557
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0056 0.0051 0.0133
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0131 0.0131
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0056 0.0051 0.014
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0028 0.0075
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.000000005167 0.000000005167
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0007 0.0044
Echinococcus granulosus single minded 2 0.0039 0.003 0.003
Leishmania major phosphatidylinositol kinase related protein, putative 0.0161 0.0184 0.0498
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0131 0.0859
Loa Loa (eye worm) hypothetical protein 0.005 0.0043 0.0316
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0073 0.0637
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.5649
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.021 0.0246 0.0246
Echinococcus granulosus expressed conserved protein 0.0089 0.0093 0.0093
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0007 0.0044
Plasmodium vivax unspecified product 0.015 0.017 0.5893
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.021 0.0246 0.0703
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0145 0.0164 0.0466
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0164 0.1569
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0017 0.0127
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0025 0.0185
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.000000005167 0.000000005167
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0713 0.0882 0.0882
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.0425
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Entamoeba histolytica hypothetical protein 0.0145 0.0164 0.1515
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0028 0.0209
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0841 0.1044 0.3006
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0233
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0095 0.01 0.01
Plasmodium falciparum GAF domain-related protein, putative 0.0036 0.0025 0.0732
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0131 0.0966
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Echinococcus granulosus cyclin dependent kinase 19 0.0147 0.0166 0.0166
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Echinococcus granulosus protein kinase shaggy 0.0056 0.0051 0.0051
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0031 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0416 0.0507 0.4821
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0104 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0365 0.0442 0.4196
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0031 0.0031
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0693 0.0856 0.971
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0702 0.0869 0.2501
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0021 0.0241
Schistosoma mansoni intermediate filament proteins 0.0029 0.0017 0.0113
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0131 0.0371

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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