Detailed information for compound 1695055

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.193 | Formula: C12H19BrN2O6
  • H donors: 3 H acceptors: 4 LogP: -0.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC1N([C@H]2C[C@@H]([C@H](O2)CO)O)C(=O)NC(=O)C1(C)Br
  • InChi: 1S/C12H19BrN2O6/c1-3-20-10-12(2,13)9(18)14-11(19)15(10)8-4-6(17)7(5-16)21-8/h6-8,10,16-17H,3-5H2,1-2H3,(H,14,18,19)/t6-,7+,8+,10?,12?/m0/s1
  • InChiKey: BMLVQJNITGJOAB-IDPSTWFOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thymidine kinase 2 Starlite/ChEMBL References
Rattus norvegicus Thymidine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis transfer RNA-Ile Get druggable targets OG5_133103 All targets in OG5_133103
Echinococcus granulosus Thymidine kinase 2 mitochondrial Get druggable targets OG5_133103 All targets in OG5_133103
Giardia lamblia Thymidine kinase Get druggable targets OG5_129576 All targets in OG5_129576
Schistosoma japonicum ko:K00857 thymidine kinase [EC2.7.1.21], putative Get druggable targets OG5_133103 All targets in OG5_133103
Leishmania braziliensis thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Echinococcus multilocularis thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Trypanosoma cruzi thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Leishmania mexicana thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Trypanosoma brucei thymidine kinase Get druggable targets OG5_129576 All targets in OG5_129576
Echinococcus multilocularis thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Leishmania donovani thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Leishmania infantum thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Schistosoma japonicum similar to Centrosomal protein of 97 kDa, putative Get druggable targets OG5_133103 All targets in OG5_133103
Trypanosoma cruzi thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Trichomonas vaginalis thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Trypanosoma congolense thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Trichomonas vaginalis thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Trypanosoma congolense thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Schistosoma mansoni thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Leishmania major thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Echinococcus granulosus thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
Trypanosoma congolense thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Entamoeba histolytica thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Trichomonas vaginalis thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Trypanosoma brucei gambiense thymidine kinase, putative Get druggable targets OG5_129576 All targets in OG5_129576
Echinococcus granulosus thymidine kinase Get druggable targets OG5_133103 All targets in OG5_133103
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Thymidine kinase   121 aa 109 aa 25.7 %
Candida albicans similar to S. cerevisiae MutS-like gene Thymidine kinase   121 aa 101 aa 26.7 %
Schistosoma mansoni protein phosphatase 2C Thymidine kinase   121 aa 119 aa 24.4 %
Trichomonas vaginalis conserved hypothetical protein Thymidine kinase   121 aa 115 aa 20.0 %
Candida albicans similar to S. cerevisiae MutS-like gene Thymidine kinase   121 aa 101 aa 26.7 %
Mycobacterium tuberculosis Probable thiol peroxidase Tpx Thymidine kinase   121 aa 103 aa 26.2 %
Theileria parva ATP synthase F1, gamma chain, putative Thymidine kinase   121 aa 105 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0029
Echinococcus granulosus dnaJ subfamily B 0.0417 0.2166 0.6342
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0009 0.0003 0.0021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.0129 0.1132
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Schistosoma mansoni synaptojanin 0.0009 0.0003 0.0009
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0001 0.0005
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0092 0.0446 0.2873
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0587
Schistosoma mansoni tar DNA-binding protein 0.006 0.0275 0.0805
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0204 0.0598
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0183 0.0535
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0009 0.0003 0.0021
Schistosoma mansoni DNA topoisomerase type I 0.0092 0.0446 0.1307
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0184 0.1613
Echinococcus granulosus cpg binding protein 0.0031 0.0121 0.0355
Trichomonas vaginalis thymidine kinase, putative 0.0301 0.1554 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.1132
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0009 0.0003 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0009 0.0003 0.0021
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Brugia malayi hypothetical protein 0.0054 0.0242 0.2114
Schistosoma mansoni hypothetical protein 0.0106 0.0519 0.152
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0055 0.0055
Mycobacterium tuberculosis Conserved protein 0.0032 0.0129 0.0207
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0033 0.0212
Schistosoma mansoni tar DNA-binding protein 0.006 0.0275 0.0805
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0001 0.0004
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0009 0.0003 0.0009
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0183 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0407 0.262
Giardia lamblia Hypothetical protein 0.0085 0.0407 0.2605
Loa Loa (eye worm) beta-lactamase 0.0032 0.0129 0.1132
Echinococcus multilocularis thymidine kinase 0.0379 0.1965 0.1965
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.0058
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0034 0.0137 0.0877
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.1132
Schistosoma mansoni hypothetical protein 0.0046 0.0199 0.0583
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0067 0.0107
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.002 0.002
Echinococcus multilocularis synaptojanin 1 0.0009 0.0003 0.0003
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0204 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0079 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0125 0.0804
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0407 0.262
Brugia malayi isocitrate dehydrogenase 0.0018 0.0055 0.0483
Leishmania major hypothetical protein, conserved 0.0032 0.0129 0.083
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Brugia malayi RNA binding protein 0.006 0.0275 0.2406
Echinococcus granulosus thymidine kinase 0.0379 0.1965 0.5753
Plasmodium vivax exodeoxyribonuclease III, putative 0.0009 0.0003 0.0044
Loa Loa (eye worm) DNA topoisomerase I 0.0123 0.0611 0.5344
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0029
Mycobacterium tuberculosis Conserved protein 0.0032 0.0129 0.0207
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0242 0.1554
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Schistosoma mansoni nocturnin 0.0009 0.0003 0.0009
Plasmodium falciparum topoisomerase I 0.0123 0.0611 1
Leishmania major DNA topoisomerase IB, large subunit 0.0092 0.0446 0.2871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0183 0.1175
Brugia malayi TAR-binding protein 0.006 0.0275 0.2406
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0029
Schistosoma mansoni hypothetical protein 0.0417 0.2166 0.6342
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.002 0.0058
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0217 0.1105 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0092 0.0592
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0129 0.0379
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0009 0.0003 0.0021
Echinococcus multilocularis transfer RNA-Ile 0.0379 0.1965 0.1965
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0204 0.1789
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0407 0.262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.002 0.0175
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0009 0.0003 0.0021
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0184 0.1183
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0104 0.0167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0184 0.1186
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0009 0.0003 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.002 0.0175
Giardia lamblia GTOR 0.0043 0.0183 0.1157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0204 0.0598
Schistosoma mansoni coup transcription factor 0.0012 0.002 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0104 0.0912
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0021
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0005 0.0044
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.002 0.0175
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0085 0.0407 0.1192
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0009 0.0003 0.0044
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0184 0.3012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0032 0.0129 0.0207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0061 0.0097
Brugia malayi nuclear receptor NHR-88 0.0012 0.002 0.0175
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0085 0.0407 0.0407
Schistosoma mansoni cript-related 0.0009 0.0003 0.0009
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0003 0.0028
Schistosoma mansoni DNA topoisomerase type I 0.0092 0.0446 0.1307
Leishmania major pantothenate kinase subunit, putative 0.001 0.0009 0.0056
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0184 0.0184
Onchocerca volvulus 0.0032 0.0129 0.6294
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0009 0.0003 0.0044
Schistosoma mansoni nuclear hormone receptor 0.0012 0.002 0.0058
Loa Loa (eye worm) TAR-binding protein 0.006 0.0275 0.2406
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0032 0.0129 0.0207
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0003 0.0028
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0207 0.1056 0.1698
Loa Loa (eye worm) hypothetical protein 0.0106 0.0519 0.4544
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0104 0.0167
Mycobacterium tuberculosis Probable esterase LipL 0.0032 0.0129 0.0207
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0085 0.0085
Loa Loa (eye worm) oxidoreductase 0.0008 0.0001 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0217 0.1903
Echinococcus granulosus FTZ F1 alpha 0.0012 0.002 0.0058
Brugia malayi beta-lactamase family protein 0.0032 0.0129 0.1132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.002 0.002
Echinococcus multilocularis tar DNA binding protein 0.006 0.0275 0.0275
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0129 0.2112
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.002 0.0951
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0129 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0407 0.262
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0009 0.0003 0.0021
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0031 0.0122 0.0782
Mycobacterium tuberculosis Probable exported protein 0.0009 0.0003 0.0004
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0067 0.1091
Brugia malayi hypothetical protein 0.0224 0.1143 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0963
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0009 0.0003 0.0021
Brugia malayi hypothetical protein 0.0035 0.0141 0.1233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0092 0.0592
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0021
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.002 0.0058
Onchocerca volvulus 0.0032 0.0129 0.6294
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0779 0.682
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0217 0.0637
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.0407 0.262
Onchocerca volvulus 0.0009 0.0003 0.0132
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0519 0.4544
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0009 0.0003 0.0021
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0029
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0055 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0184 0.1186
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0009 0.0003 0.0044
Schistosoma mansoni tar DNA-binding protein 0.006 0.0275 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.0175
Brugia malayi CCR4 0.0009 0.0003 0.0028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0055 0.0055
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.1182 0.6219 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.002 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.002 0.0175
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0031 0.0122 0.0782
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0028
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0055 0.05
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0047
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0009 0.0003 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.0032 0.0129 0.0207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0104 0.0912
Mycobacterium ulcerans beta-lactamase 0.0032 0.0129 0.0207
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0003 0.0028
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0067 0.0107
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0055 0.0055
Onchocerca volvulus 0.0047 0.0205 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0779 0.682
Mycobacterium ulcerans hypothetical protein 0.0032 0.0129 0.0207
Brugia malayi steroid hormone receptor 0.0012 0.002 0.0175
Brugia malayi Deoxynucleoside kinase family protein 0.0085 0.0407 0.3563
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.002 0.0058
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0242 0.2185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0587
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.0175
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0217 0.1903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0033 0.0212
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0379 0.1965 0.5753
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0184 0.0539
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0003 0.0028
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.002 0.0058
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0001 0.0004
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0009 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0137 0.0879
Echinococcus granulosus GPCR family 2 0.0049 0.0217 0.0637
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0104 0.0167
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0004
Mycobacterium tuberculosis Probable hydrolase 0.0032 0.0129 0.0207
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.002 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0407 0.262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.002 0.0175
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0184 0.1643
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.0175
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0104 0.0167
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0184 0.0296
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.002 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0079 0.0507
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.002 0.0175
Brugia malayi DNA topoisomerase I 0.0123 0.0611 0.5344
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.002 0.0058
Trypanosoma cruzi thymidine kinase, putative 0.0301 0.1554 1
Leishmania major thymidine kinase, putative 0.0301 0.1554 1
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0009 0.0003 0.0021
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0055 0.0355
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0912
Mycobacterium tuberculosis Conserved hypothetical protein 0.0217 0.1105 0.1777
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0217 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0137 0.0879
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0055 0.05
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0001 0.0004
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0009 0.0003 0.0044
Echinococcus multilocularis microtubule associated protein 2 0.0653 0.3416 0.3416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0204 0.0598
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0113 0.0985
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.0058
Giardia lamblia Thymidine kinase 0.0301 0.1554 1
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0009 0.0003 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0049 0.0217 0.0637
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0129 0.0833
Echinococcus multilocularis thymidine kinase 0.0379 0.1965 0.1965
Mycobacterium tuberculosis Conserved hypothetical protein 0.0217 0.1105 0.1777
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0104 0.0671
Echinococcus granulosus neutral sphingomyelinase 0.0009 0.0003 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0061 0.0097
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0184 0.1186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0184 0.1186
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0003 0.0028
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Onchocerca volvulus 0.0029 0.0113 0.5469
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.0407 0.262
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0055 0.0483
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0061 0.0097
Loa Loa (eye worm) deoxynucleoside kinase 0.0085 0.0407 0.3563
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.0407 0.262
Echinococcus multilocularis deoxyribonuclease 1 2 0.0009 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0137 0.0879
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0184 0.0296
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0129 0.0833
Loa Loa (eye worm) hypothetical protein 0.0047 0.0205 0.1797
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.002 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0125 0.0804
Echinococcus multilocularis survival motor neuron protein 1 0.0224 0.1143 0.1143
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0217 0.0637
Trichomonas vaginalis thymidine kinase, putative 0.0301 0.1554 1
Mycobacterium tuberculosis Probable lipase LipD 0.0032 0.0129 0.0207
Echinococcus granulosus synaptojanin 1 0.0009 0.0003 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.0058
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0079 0.0507
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0092 0.0446 0.2873
Loa Loa (eye worm) hypothetical protein 0.0224 0.1143 1
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0085 0.0407 0.2605
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0275 0.2406
Trypanosoma cruzi mitochondrial protein 99, putative 0.0009 0.0003 0.0021
Onchocerca volvulus 0.0012 0.002 0.0951
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0029
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.002 0.0175
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.0033 0.0033
Schistosoma mansoni cpg binding protein 0.0031 0.0121 0.0355
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.1132
Echinococcus multilocularis GPCR, family 2 0.0049 0.0217 0.0217
Plasmodium vivax topoisomerase I, putative 0.0123 0.0611 1
Mycobacterium ulcerans lipase LipD 0.0032 0.0129 0.0207
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0183 0.1175
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0183 0.1598
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0055 0.0162
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0034 0.0137 0.088
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0014 0.0033 0.0209
Mycobacterium ulcerans esterase/lipase LipP 0.0032 0.0129 0.0207
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0183 0.1175
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0067 0.5
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0055 0.0355
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.002 0.0058
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0021
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.2166 0.2166
Echinococcus granulosus microtubule associated protein 2 0.0653 0.3416 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0129 0.0833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0204 0.0204
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0085 0.0407 0.262
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.002 0.0175
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0199 0.1743
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0051 0.0328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0079 0.0508
Schistosoma mansoni hypothetical protein 0.0049 0.0217 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0091 0.0583
Schistosoma mansoni microtubule-associated protein tau 0.0653 0.3416 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.002 0.0175
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0055 0.0355
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0017
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0055 0.0355
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0001 0.0003
Echinococcus granulosus survival motor neuron protein 1 0.0224 0.1143 0.3345
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0183 0.1175
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.0058
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0001 0.0003
Toxoplasma gondii DNA topoisomerase I, putative 0.0123 0.0611 0.5524
Brugia malayi ecdysteroid receptor 0.0012 0.002 0.0175
Echinococcus multilocularis traf and tnf receptor associated protein 0.0009 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.002 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0125 0.0804
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0125 0.0804
Schistosoma mansoni cpg binding protein 0.0029 0.0113 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.002 0.0175
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0005 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0079 0.0507
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0032 0.0129 0.0207
Onchocerca volvulus 0.0009 0.0003 0.0132
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0242 0.3951
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0104 0.0912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0125 0.0804
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0242 0.1554
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0183 0.1175
Entamoeba histolytica thymidine kinase, putative 0.0301 0.1554 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0091 0.0583
Onchocerca volvulus Putative neutral sphingomyelinase 0.0009 0.0003 0.0132
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0183 0.1172
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0183 0.1598
Brugia malayi CXXC zinc finger family protein 0.0029 0.0113 0.0985
Echinococcus granulosus traf and tnf receptor associated protein 0.0009 0.0003 0.0009
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0001 0.0005
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0033 0.0212
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0129 0.0833
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0912
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0217 0.1105 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0184 0.1168
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0001 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0092 0.0592
Leishmania major DNA topoisomerase type IB small subunit 0.0031 0.0122 0.0779
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0009 0.0003 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0217 0.0217
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0129 0.0833
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0184 0.1186
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.002 0.0058
Plasmodium falciparum DNase I-like protein, putative 0.0009 0.0003 0.0044
Schistosoma mansoni survival motor neuron protein 0.0046 0.0199 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0108 0.0698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0033 0.0212
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0009 0.0003 0.0021
Schistosoma mansoni hypothetical protein 0.0024 0.0085 0.0248
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0055 0.0055
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1182 0.6219 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0125 0.0804
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.1182 0.6219 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.0058
Schistosoma mansoni ap endonuclease 0.0043 0.0184 0.0539
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0001 0.0001
Trichomonas vaginalis esterase, putative 0.0032 0.0129 0.0833
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0009 0.0003 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0033 0.0212
Trypanosoma brucei thymidine kinase 0.0301 0.1554 1
Mycobacterium leprae Probable lipase LipE 0.0032 0.0129 0.0207
Echinococcus granulosus tumor protein p63 0.032 0.1651 0.4833
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0183 0.1175
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0009 0.0003 0.0021
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.0205 0.0601
Trypanosoma cruzi target of rapamycin kinase 3 0.0034 0.0137 0.088
Onchocerca volvulus 0.0028 0.0104 0.5064
Treponema pallidum licC protein (licC) 0.0217 0.1105 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0779 0.682
Giardia lamblia Hypothetical protein 0.0085 0.0407 0.2605
Echinococcus granulosus tar DNA binding protein 0.006 0.0275 0.0805
Entamoeba histolytica hypothetical protein 0.0085 0.0407 0.262
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0251 0.2273
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.0175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0217 0.1903
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0001 0.0005
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0009 0.0003 0.0021
Leishmania major phosphatidylinositol 3-kinase, putative 0.0014 0.0033 0.0209
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Giardia lamblia Deoxynucleoside kinase 0.0085 0.0407 0.2605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0079 0.0508
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.1132
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0104 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0028
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0001 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0104 0.0671
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.002 0.0058
Toxoplasma gondii ABC1 family protein 0.0032 0.0129 0.117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0204 0.0598
Schistosoma mansoni hypothetical protein 0.0049 0.0217 0.0637
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0104 0.0167
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.002
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Leishmania major hypothetical protein, conserved 0.0054 0.0242 0.1551
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0009 0.0003 0.0021
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0009 0.0003 0.0003
Mycobacterium ulcerans hypothetical protein 0.0217 0.1105 0.1777
Echinococcus granulosus thymidine kinase 0.0379 0.1965 0.5753
Loa Loa (eye worm) RNA binding protein 0.006 0.0275 0.2406
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0183 0.1175
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0104 0.0671
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0129 0.0207
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0125 0.113
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0033 0.0288
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0001 0.0003
Toxoplasma gondii exonuclease III APE 0.0043 0.0184 0.1667
Trypanosoma cruzi pantothenate kinase subunit, putative 0.001 0.0009 0.0059
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0055 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.002 0.0175
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0033 0.0288
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0009 0.0003 0.0028
Mycobacterium ulcerans hypothetical protein 0.0217 0.1105 0.1777
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0009 0.0003 0.0021
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0009 0.0003 0.0021
Trichomonas vaginalis Phospholipase C precursor, putative 0.0009 0.0003 0.0021
Echinococcus multilocularis cpg binding protein 0.0031 0.0121 0.0121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.002
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.0058
Mycobacterium tuberculosis Conserved protein 0.0032 0.0129 0.0207
Mycobacterium ulcerans hypothetical protein 0.0028 0.0104 0.0167
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0587
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0104 0.0167
Leishmania major RNA-editing complex protein MP100, putative 0.0009 0.0003 0.0017
Schistosoma mansoni cpg binding protein 0.0031 0.0121 0.0355
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0085 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.002 0.0175
Echinococcus granulosus DNA topoisomerase 1 0.0123 0.0611 0.1787
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0104 0.0668
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0001 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0242 0.3951
Trypanosoma brucei RNA editing exonuclease 2 0.0009 0.0003 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0204 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0125 0.0804
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0204 0.1789
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.0064 0.0411
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0009 0.0003 0.0044
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0009 0.0003 0.0021
Echinococcus multilocularis neutral sphingomyelinase 0.0009 0.0003 0.0003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0104 0.0167
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0129 0.0379
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.002 0.0058
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0137 0.0879
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0043
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0183 0.1175
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Schistosoma mansoni ap endonuclease 0.0043 0.0184 0.0539
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0184 0.1613
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0055 0.0897
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0001 0.0003
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0085 0.0407 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.002 0.0175
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0001 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.002 0.0058
Brugia malayi nuclear hormone receptor 0.0012 0.002 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0033 0.0212
Onchocerca volvulus 0.0046 0.0199 0.97
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.002 0.0175
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0009 0.0003 0.0021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.002 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.0129 0.1132
Trichomonas vaginalis thymidine kinase, putative 0.0301 0.1554 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0055 0.0897
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0014 0.0033 0.0212
Loa Loa (eye worm) hypothetical protein 0.0155 0.0779 0.682
Loa Loa (eye worm) hypothetical protein 0.0054 0.0242 0.2114
Schistosoma mansoni thymidine kinase 0.0379 0.1965 0.5753
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0286 0.0838
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0009 0.0003 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0104 0.0667
Schistosoma mansoni hypothetical protein 0.0049 0.0217 0.0637
Brugia malayi beta-lactamase 0.0032 0.0129 0.1132
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0242 0.1554
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.002 0.0175
Schistosoma mansoni tar DNA-binding protein 0.006 0.0275 0.0805
Trypanosoma cruzi thymidine kinase, putative 0.0301 0.1554 1
Schistosoma mansoni DNA topoisomerase type I 0.0123 0.0611 0.1787
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0587
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.0058
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0009 0.0003 0.0003
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.1182 0.6219 1
Trypanosoma cruzi mitochondrial protein 99, putative 0.0009 0.0003 0.0021
Brugia malayi beta-lactamase family protein 0.0032 0.0129 0.1132
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0183 0.1175
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0032 0.0129 0.0207
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0104 0.0668
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0033 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.0175
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0183 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0079 0.0508
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0028
Leishmania major endonuclease/exonuclease protein-like protein 0.0009 0.0003 0.0017
Schistosoma mansoni neutral sphingomyelinase 0.0009 0.0003 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0242 0.3951
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0217 0.1903
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0137 0.0879
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0055 0.0162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0275 0.2406
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0912
Echinococcus multilocularis DNA topoisomerase 1 0.0123 0.0611 0.0611
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0009 0.0003 0.0044
Schistosoma mansoni carbon catabolite repressor protein 0.0009 0.0003 0.0009
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0029
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.0033 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0018 0.0115
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0009 0.0003 0.0021
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0587
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0009 0.0003 0.0021
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.006 0.0275 0.0805
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.0175
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0104 0.0668
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0014 0.0033 0.0212
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.002 0.0058
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0055 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0129 0.0833
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0009 0.0003 0.0021
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0009 0.0003 0.0029
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0067 0.1091
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.002 0.0951
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0001 0.0003
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0014 0.0033 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0129 0.0833
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0184 0.1186
Schistosoma mansoni synaptojanin 0.0009 0.0003 0.0009
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0009 0.0003 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0055 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0104 0.0167
Onchocerca volvulus 0.0032 0.0129 0.6294
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.0129 0.0379
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0001 0.0003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0184 0.3012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0061 0.0097
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0009 0.0003 0.0021
Echinococcus multilocularis tumor protein p63 0.032 0.1651 0.1651

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.002 mM Competitive inhibition against rat cytoplasmic Thymidine kinase ChEMBL. 7097717
Ki (binding) = 0.0039 mM Competitive inhibition against rat cytoplasmic Thymidine kinase ChEMBL. 7097717
Ki (binding) = 0.011 mM Competitive inhibition against rat mitochondrial thymidine kinase ChEMBL. 7097717
Ki (binding) = 0.18 mM Competitive inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP by Lineweaver-Burk plot analysis ChEMBL. 458818
Ki (binding) = 0.31 mM Competitive inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP by Lineweaver-Burk plot analysis ChEMBL. 458818
Ki (binding) = 24 uM Competitive inhibition of thymidine kinase in mouse Ehrlich's ascites cells ChEMBL. 458818
Relative affinity (binding) = 0.41 Affinity towards cytoplasmic Thymidine kinase relative ot TdR. ChEMBL. 7097717
Relative affinity (binding) = 0.73 Affinity towards mitochondrial thymidine kinase relative to TdR. ChEMBL. 7097717
Relative affinity (binding) = 0.8 Affinity towards cytoplasmic Thymidine kinase relative ot TdR. ChEMBL. 7097717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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