Detailed information for compound 173039

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.381 | Formula: C21H30Cl2N2O2
  • H donors: 0 H acceptors: 1 LogP: 4.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)OCCCC(=O)N([C@@H]1CCCC[C@@H]1N1CCCC1)C
  • InChi: 1S/C21H30Cl2N2O2/c1-24(18-7-2-3-8-19(18)25-12-4-5-13-25)21(26)9-6-14-27-20-11-10-16(22)15-17(20)23/h10-11,15,18-19H,2-9,12-14H2,1H3/t18?,19-/m1/s1
  • InChiKey: RQIUSCCNFMWMFJ-MUMRKEEXSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.012 0.0172 0.2334
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1097 0.1896 0.1878
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0378 0.0629 0.0613
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.012 0.0172 0.0172
Brugia malayi TAR-binding protein 0.0126 0.0183 0.0179
Plasmodium vivax hypothetical protein 0.0378 0.0629 0.9408
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0183 0.0166
Plasmodium vivax hypothetical protein, conserved 0.014 0.0209 0.2989
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0017 0.0017
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.04 0.0667 0.0667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Loa Loa (eye worm) hypothetical protein 0.0378 0.0629 0.0613
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5692 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0378 0.0629 0.0608
Echinococcus multilocularis survival motor neuron protein 1 0.0698 0.1192 0.1192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0718 0.1228 0.1214
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0034 0.0022 0.0055
Onchocerca volvulus 0.0378 0.0629 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0142 0.0212 0.0212
Mycobacterium tuberculosis Probable lipase LipE 0.014 0.0209 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0017 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Mycobacterium tuberculosis Conserved protein 0.014 0.0209 0.1278
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0378 0.0629 0.0629
Onchocerca volvulus 0.0144 0.0216 0.3294
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0042 0.0042
Echinococcus granulosus expressed conserved protein 0.0275 0.0446 0.0446
Loa Loa (eye worm) hypothetical protein 0.0042 0.0035 0.0018
Echinococcus multilocularis Niemann Pick C1 protein 0.0418 0.0699 0.0699
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0167 0.0163
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1222 0.2115 0.2827
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0378 0.0629 0.94
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0378 0.0629 0.0828
Trichomonas vaginalis PIKK family atypical protein kinase 0.309 0.5412 0.5404
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1996 0.3481 0.3467
Trichomonas vaginalis PIKK family atypical protein kinase 0.1097 0.1896 0.1882
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0209 0.0188
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0782 0.1341 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.012 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0167 0.1634
Trichomonas vaginalis glutaminase, putative 0.0539 0.0911 0.0896
Echinococcus granulosus GPCR family 2 0.0156 0.0236 0.0236
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1996 0.3481 0.3481
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0017 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5692 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0103 0.0143 0.0143
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.04 0.0667 0.0652
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0013 0.0013
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.059 0.1002 0.0982
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Loa Loa (eye worm) hypothetical protein 0.0117 0.0167 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Leishmania major hypothetical protein, conserved 0.048 0.0807 0.0787
Echinococcus multilocularis protein patched 0.0126 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0069 0.0083 0.0067
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0167 0.0163
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0117 0.0167 0.2396
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5692 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0087 0.0115 0.1446
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0546 0.0923 0.0904
Loa Loa (eye worm) beta-lactamase 0.014 0.0209 0.0192
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0042 0.0042
Plasmodium vivax acyl-CoA synthetase, putative 0.0087 0.0115 0.1556
Mycobacterium ulcerans hypothetical protein 0.014 0.0209 0.2103
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.0745 0.0725
Leishmania major phosphatidylinositol kinase related protein, putative 0.0378 0.0629 0.0608
Echinococcus granulosus Niemann Pick C1 protein 0.0293 0.0477 0.0477
Entamoeba histolytica hypothetical protein 0.0378 0.0629 0.0608
Loa Loa (eye worm) hypothetical protein 0.0445 0.0745 0.073
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.012 0.0172 0.0168
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0017 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0117 0.0167 0.2396
Brugia malayi latrophilin 2 splice variant baaae 0.0337 0.0555 0.0551
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0214 0.0339 0.0339
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0445 0.0746 0.0726
Trichomonas vaginalis PIKK family atypical protein kinase 0.5692 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0017 0.0017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0117 0.0167 0.1006
Echinococcus granulosus tar DNA binding protein 0.0126 0.0183 0.0183
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0034 0.0022 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.3403 0.5962 0.5955
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Leishmania major hypothetical protein, conserved 0.014 0.0209 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.5692 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0337 0.0555 0.0555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Mycobacterium leprae Probable lipase LipE 0.014 0.0209 0.3082
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.059 0.1002 0.0998
Mycobacterium tuberculosis Probable lipase LipD 0.014 0.0209 0.1278
Brugia malayi Pre-SET motif family protein 0.0206 0.0324 0.032
Brugia malayi beta-lactamase 0.014 0.0209 0.0205
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0034 0.0022 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0121 0.0121
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0378 0.0629 0.0608
Echinococcus granulosus survival motor neuron protein 1 0.0698 0.1192 0.1192
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.04 0.0667 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.04 0.0667 0.0667
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0212 0.0334 0.0314
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0324 0.0308
Loa Loa (eye worm) phosphatidylinositol kinase 0.0378 0.0629 0.0613
Toxoplasma gondii target of rapamycin (TOR), putative 0.4246 0.7449 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0117 0.0167 0.1634
Trichomonas vaginalis antibiotic synthetase, putative 0.0034 0.0022 0.0005
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0034 0.0022 0.0011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5692 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0067 0.0078 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0107 0.0611
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Schistosoma mansoni hypothetical protein 0.0214 0.0339 0.0339
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.012 0.0172 0.0172
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0087 0.0115 0.5
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0034 0.0022 0.0055
Onchocerca volvulus 0.014 0.0209 0.3177
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0378 0.0629 0.0828
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0183 0.0179
Echinococcus granulosus sterol regulatory element binding protein 0.0126 0.0183 0.0183
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0034 0.0022 0.0055
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.012 0.0172 0.0151
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0293 0.0477 0.0457
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.014 0.0209 0.0205
Loa Loa (eye worm) hypothetical protein 0.0046 0.0043 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.1109 0.1917 0.1903
Loa Loa (eye worm) oxidoreductase 0.0034 0.0022 0.0005
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0843 0.1448 0.1448
Echinococcus granulosus microtubule associated protein 2 0.2729 0.4774 0.4774
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0513 0.0866 0.0863
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.309 0.5412 0.5404
Trichomonas vaginalis PIKK family atypical protein kinase 0.3403 0.5962 0.5955
Brugia malayi Pre-SET motif family protein 0.003 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0117 0.0167 0.0151
Onchocerca volvulus 0.0034 0.0022 0.0136
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0172 0.0151
Trichomonas vaginalis esterase, putative 0.014 0.0209 0.0192
Loa Loa (eye worm) hypothetical protein 0.0513 0.0866 0.0851
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5692 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.1952 0.3404 0.3393
Loa Loa (eye worm) hypothetical protein 0.0843 0.1448 0.1434
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0043 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0121 0.0121
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0522 0.0881 0.0866
Brugia malayi hypothetical protein 0.0214 0.0339 0.0335
Schistosoma mansoni microtubule-associated protein tau 0.2729 0.4774 0.4774
Echinococcus multilocularis sterol regulatory element binding protein 0.0126 0.0183 0.0183
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.014 0.0209 0.1278
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0167 0.0146
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0005 0.0005
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.04 0.0667 0.0647
Loa Loa (eye worm) hypothetical protein 0.0154 0.0232 0.0216
Brugia malayi Bromodomain containing protein 0.0073 0.009 0.0086
Giardia lamblia GTOR 0.5692 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.012 0.0172 0.1694
Loa Loa (eye worm) hypothetical protein 0.0034 0.0022 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.014 0.0209 0.0188
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0121 0.0117
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0034 0.0022 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0209 0.0192
Leishmania major hypothetical protein, unknown function 0.0378 0.0629 0.0608
Brugia malayi CHE-14 protein 0.0126 0.0183 0.0179
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.012 0.0172 0.0168
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0142 0.0212 0.0208
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0378 0.0629 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.012 0.0172 0.0151
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0445 0.0746 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0843 0.1448 0.1434
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Trichomonas vaginalis conserved hypothetical protein 0.1222 0.2115 0.2102
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0209 0.0188
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Loa Loa (eye worm) hypothetical protein 0.0698 0.1192 0.1178
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.0745 0.0725
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0034 0.0022 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0445 0.0746 0.0726
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Schistosoma mansoni patched 1 0.0126 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.4849 0.8513 0.8511
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0034 0.0022 0.0055
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0117 0.0167 0.0151
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0493 0.083 0.0826
Brugia malayi Bromodomain containing protein 0.0037 0.0027 0.0023
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.014 0.0209 0.0192
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0144 0.0216 0.02
Loa Loa (eye worm) hypothetical protein 0.115 0.199 0.1977
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0156 0.0236 0.0236
Leishmania major peptidylprolyl isomerase-like protein 0.012 0.0172 0.0151
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0664 0.1132 0.1132
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0782 0.1341 0.1341
Trichomonas vaginalis PIKK family atypical protein kinase 0.1529 0.2658 0.2645
Onchocerca volvulus 0.0234 0.0374 0.5866
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0378 0.0629 0.9408
Echinococcus multilocularis GPCR, family 2 0.0156 0.0236 0.0236
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0042 0.0042
Onchocerca volvulus 0.014 0.0209 0.3177
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.012 0.0172 0.0156
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.04 0.0667 0.0652
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149 0.0224 0.0207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1097 0.1896 0.1892
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1996 0.3481 0.3481
Loa Loa (eye worm) hypothetical protein 0.1097 0.1896 0.1882
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5692 1 1
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.1952 0.3404 0.3393
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0629 0.0625
Brugia malayi AMP-binding enzyme family protein 0.0117 0.0167 0.0163
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0172 0.0151
Mycobacterium tuberculosis Probable esterase LipL 0.014 0.0209 0.1278
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.04 0.0667 0.0647
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.059 0.1002 0.0987
Schistosoma mansoni hypothetical protein 0.0378 0.0629 0.0629
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0159 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0337 0.0555 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0043 0.0043
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0374 0.0358
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.012 0.0172 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0209 0.0209
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0897 0.1543 1
Schistosoma mansoni immunophilin 0.012 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.3403 0.5962 0.5955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0629 0.0625
Brugia malayi hypothetical protein 0.0698 0.1192 0.1189
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0378 0.0629 0.9408
Trichomonas vaginalis PIKK family atypical protein kinase 0.3387 0.5934 0.5927
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.04 0.0667 0.0667
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0011 0.0011
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0034 0.0022 0.0011
Loa Loa (eye worm) glutaminase 2 0.0539 0.0911 0.0896
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5692 1 1
Mycobacterium tuberculosis Conserved protein 0.014 0.0209 0.1278
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0297 0.0485 0.0485
Giardia lamblia Hypothetical protein 0.0378 0.0629 0.0464
Toxoplasma gondii ABC1 family protein 0.014 0.0209 0.0263
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0782 0.1341 0.1341
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1097 0.1896 0.1896
Loa Loa (eye worm) hypothetical protein 0.0227 0.0362 0.0346
Mycobacterium ulcerans hypothetical protein 0.0117 0.0167 0.1634
Loa Loa (eye worm) hypothetical protein 0.0077 0.0097 0.008
Echinococcus multilocularis Zinc finger, PHD finger 0.04 0.0667 0.0667
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0378 0.0629 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Trichomonas vaginalis PIKK family atypical protein kinase 0.3819 0.6696 0.669
Mycobacterium tuberculosis Conserved hypothetical protein 0.0378 0.0629 0.4023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0121 0.0121
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5692 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Loa Loa (eye worm) hypothetical protein 0.1222 0.2115 0.2102
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.04 0.0667 0.088
Plasmodium vivax acetyl-CoA synthetase, putative 0.0034 0.0022 0.0128
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0718 0.1228 0.1209
Echinococcus granulosus serine protein kinase ATM 0.1097 0.1896 0.1896
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0017 0.0017
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0156 0.0236 0.0232
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0209 0.0192
Leishmania major phosphatidylinositol 3-kinase, putative 0.194 0.3383 0.3368
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.194 0.3383 0.3368
Trichomonas vaginalis antibiotic synthetase, putative 0.0034 0.0022 0.0005
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0378 0.0629 0.0608
Trichomonas vaginalis fk506-binding protein, putative 0.012 0.0172 0.0156
Schistosoma mansoni immunophilin 0.012 0.0172 0.0172
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Loa Loa (eye worm) hypothetical protein 0.004 0.0031 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0214 0.0339 0.0339
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0378 0.0629 0.0608
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0209 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Echinococcus granulosus Niemann Pick C1 protein 0.0418 0.0699 0.0699
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.0078 0.0062
Leishmania major fk506-binding protein 1-like protein 0.012 0.0172 0.0151
Loa Loa (eye worm) hypothetical protein 0.0046 0.0042 0.0026
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0445 0.0746 0.073
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0477 0.0803 0.0642
Onchocerca volvulus 0.0034 0.0022 0.0136
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0017 0.0017
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Giardia lamblia Phosphatidylinositol 4-kinase 0.0378 0.0629 0.0464
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0192 0.03 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0042 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0121 0.0121
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0013 0.0013
Leishmania major phosphatidylinositol 3-kinase, putative 0.04 0.0667 0.0647
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0017 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0214 0.0339 0.0339
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0017 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0209 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0209 0.0209
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Echinococcus granulosus tumor protein p63 0.0987 0.1702 0.1702
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0172 0.0151
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0664 0.1132 0.1132
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0087 0.0115 0.0665
Loa Loa (eye worm) FKBP5 protein 0.012 0.0172 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0023 0.0023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.014 0.0209 0.1278
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0139 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0209 0.0192
Loa Loa (eye worm) hypothetical protein 0.0493 0.083 0.0815
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Mycobacterium ulcerans esterase/lipase LipP 0.014 0.0209 0.2103
Schistosoma mansoni fkbp-rapamycin associated protein 0.1097 0.1896 0.1896
Brugia malayi Niemann-Pick C1 protein precursor 0.0293 0.0477 0.0473
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.059 0.1002 0.0987
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0378 0.0629 0.0629
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.059 0.1002 0.0987
Entamoeba histolytica protein kinase rad3, putative 0.1097 0.1896 0.1878
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0378 0.0629 0.0828
Echinococcus multilocularis serine protein kinase ATM 0.1097 0.1896 0.1896
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0159 0.0242 0.0242
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.04 0.0667 0.0652
Brugia malayi glutaminase DH11.1 0.0539 0.0911 0.0908
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0493 0.083 0.0815
Loa Loa (eye worm) hypothetical protein 0.0138 0.0205 0.0189
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1109 0.1917 0.1899
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0423 0.0707 0.0544
Echinococcus multilocularis expressed conserved protein 0.0275 0.0446 0.0446
Echinococcus multilocularis microtubule associated protein 2 0.2729 0.4774 0.4774
Schistosoma mansoni immunophilin 0.0103 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0172 0.0151
Entamoeba histolytica acyl-coA synthetase, putative 0.0117 0.0167 0.0146
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0126 0.0183 0.0166
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5692 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0156 0.0236 0.0236
Echinococcus multilocularis Niemann Pick C1 protein 0.0293 0.0477 0.0477
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0043 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1996 0.3481 0.3479
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0156 0.0236 0.0236
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0034 0.0022 0.0055
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1952 0.3404 0.3389
Trichomonas vaginalis PIKK family atypical protein kinase 0.3694 0.6476 0.647
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.04 0.0667 0.0647
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0022 0.0017
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0042 0.0042
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2406 0.4204 0.4204
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2377 0.4153 0.414
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.059 0.1002 0.0982
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0469 0.0788 0.0768
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.4537 0.7963 0.7959
Toxoplasma gondii propionate-CoA ligase 0.0034 0.0022 0.0011
Onchocerca volvulus 0.0034 0.0022 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Loa Loa (eye worm) glutaminase 0.0539 0.0911 0.0896
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.0172 0.0156
Mycobacterium ulcerans glutaminase 0.0539 0.0911 1
Loa Loa (eye worm) RNA binding protein 0.0126 0.0183 0.0167
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1996 0.3481 0.3467
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0017 0.0013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0378 0.0629 0.0608
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0117 0.0167 0.1634
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0159 0.0242 0.0226
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0034 0.0022 0.0022
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4542 0.7971 0.7967
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0183 0.0167
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0445 0.0746 0.073
Onchocerca volvulus 0.0378 0.0629 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0156 0.0236 0.022
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0378 0.0629 0.0629
Brugia malayi Calcitonin receptor-like protein seb-1 0.0493 0.083 0.0826
Entamoeba histolytica hypothetical protein 0.0378 0.0629 0.0608
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0268 0.0268
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1097 0.1896 0.1878
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1097 0.1896 0.1892
Toxoplasma gondii FATC domain-containing protein 0.1097 0.1896 0.2532
Loa Loa (eye worm) hypothetical protein 0.0103 0.0143 0.0127
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0117 0.0167 0.1634
Mycobacterium tuberculosis Probable hydrolase 0.014 0.0209 0.1278
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4542 0.7971 0.7967
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.9408
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0629 0.0613
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.012 0.0172 0.2432
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149 0.0224 0.0207
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.059 0.1002 0.0982
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0183 0.0167
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0445 0.0746 0.0726
Entamoeba histolytica hypothetical protein 0.0546 0.0923 0.0904
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.04 0.0667 1
Schistosoma mansoni acetyl-CoA synthetase 0.0034 0.0022 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.014 0.0209 0.1278
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5692 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.4542 0.7971 0.7967
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.9408
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0103 0.0143 0.0143
Brugia malayi RNA binding protein 0.0126 0.0183 0.0179
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.04 0.0667 0.0652
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0042 0.0038
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1097 0.1896 0.1896
Onchocerca volvulus 0.014 0.0209 0.3177
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.04 0.0667 0.0663
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0513 0.0866 0.0866
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5692 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0022 0.0005
Mycobacterium tuberculosis Conserved protein 0.014 0.0209 0.1278
Schistosoma mansoni hypothetical protein 0.0121 0.0175 0.0175
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.04 0.0667 0.0667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0117 0.0167 0.1006
Echinococcus multilocularis beta LACTamase domain containing family member 0.014 0.0209 0.0209
Schistosoma mansoni phosphatidylinositol 4-kinase 0.04 0.0667 0.0667
Leishmania major phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0064 0.0064
Brugia malayi beta-lactamase family protein 0.014 0.0209 0.0205
Brugia malayi beta-lactamase family protein 0.014 0.0209 0.0205
Onchocerca volvulus 0.0142 0.0212 0.3235
Loa Loa (eye worm) hypothetical protein 0.0293 0.0477 0.0461
Onchocerca volvulus 0.0117 0.0167 0.25
Mycobacterium ulcerans lipase LipD 0.014 0.0209 0.2103
Schistosoma mansoni hypothetical protein 0.0156 0.0236 0.0236
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0445 0.0746 0.073
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0156 0.0236 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.5692 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.0172 0.0156
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.0745 0.0725
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0022 0.0017
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1952 0.3404 0.3389
Plasmodium falciparum phosphatidylinositol 3-kinase 0.04 0.0667 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0156 0.0236 0.0232
Brugia malayi FAT domain containing protein 0.0843 0.1448 0.1444
Echinococcus multilocularis 0.0378 0.0629 0.0629
Entamoeba histolytica hypothetical protein 0.0378 0.0629 0.0608
Entamoeba histolytica hypothetical protein 0.1097 0.1896 0.1878
Loa Loa (eye worm) hypothetical protein 0.0087 0.0115 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Loa Loa (eye worm) phosphatidylinositol 3 0.0378 0.0629 0.0613
Loa Loa (eye worm) hypothetical protein 0.014 0.0209 0.0192
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0064 0.0064
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.0156 0.0236 0.022
Loa Loa (eye worm) phosphatidylinositol 3 0.0738 0.1262 0.1247
Schistosoma mansoni bromodomain containing protein 0.0062 0.007 0.007
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0378 0.0629 0.94
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0167 0.1634
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.012 0.0172 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1097 0.1896 0.1878
Loa Loa (eye worm) hypothetical protein 0.0126 0.0183 0.0166
Mycobacterium leprae conserved hypothetical protein 0.014 0.0209 0.3082
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0121 0.0121
Echinococcus granulosus beta LACTamase domain containing family member 0.014 0.0209 0.0209
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0117 0.0167 0.1634
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0167 0.1634
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0445 0.0746 0.0746
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0378 0.0629 0.0613
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0167 0.0146
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0513 0.0866 0.0866
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1996 0.3481 0.3481
Loa Loa (eye worm) phosphatidylinositol 3 0.5692 1 1
Trichomonas vaginalis immunophilin, putative 0.012 0.0172 0.0156
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0522 0.0881 0.0866
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0167 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0183 0.0183
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0022 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0087 0.0115 0.105
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0167 0.0146
Schistosoma mansoni cellular tumor antigen P53 0.0144 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0378 0.0629 0.0613
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0843 0.1448 0.1448
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.014 0.0209 0.2103
Leishmania major 4-coumarate:coa ligase-like protein 0.0117 0.0167 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.3387 0.5934 0.5927
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.194 0.3383 0.3371
Echinococcus multilocularis fk506 binding protein 0.012 0.0172 0.0172
Echinococcus multilocularis protein dispatched 1 0.0143 0.0214 0.0214
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.012 0.0172 0.0172
Echinococcus multilocularis tumor protein p63 0.0987 0.1702 0.1702
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0017 0.0017
Mycobacterium ulcerans beta-lactamase 0.014 0.0209 0.2103
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0034 0.0022 0.0022
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0378 0.0629 0.0608
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.1097 0.1896 0.1882
Entamoeba histolytica hypothetical protein 0.0214 0.0339 0.0318
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2684 0.4695 0.4683
Echinococcus granulosus Protein patched homolog 1 0.0126 0.0183 0.0183
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0159 0.0242 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0718 0.1228 0.1214
Schistosoma mansoni survival motor neuron protein 0.0142 0.0212 0.0212
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.012 0.0172 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0445 0.0746 0.0726
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1097 0.1896 0.1896
Schistosoma mansoni hypothetical protein 0.0843 0.1448 0.1448
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0378 0.0629 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.309 0.5412 0.5404
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0034 0.0022 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.7449 0.7444
Trichomonas vaginalis PIKK family atypical protein kinase 0.3095 0.542 0.5412
Mycobacterium leprae conserved hypothetical protein 0.0378 0.0629 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0378 0.0629 0.0608
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0268 0.0268
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0121 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.1228 0.1214
Schistosoma mansoni glutaminase 0.0539 0.0911 0.0911
Onchocerca volvulus 0.0034 0.0022 0.0136

Activities

Activity type Activity value Assay description Source Reference
Control (binding) = 43.37 % Binding affinity against opioid receptor kappa 1 using [3H]U-69,593 as a radioligand ChEMBL. 2172538
Control (binding) = 88.16 % Binding affinity against opioid receptor kappa 1 using with [3H]-bremazocine as radioligand ChEMBL. 2172538
IC50 (binding) = 418 nM Binding affinity for sigma opioid receptor using [3H]-(+)-3-PPP as radioligand ChEMBL. 2172538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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