Detailed information for compound 1746067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 966.127 | Formula: C49H71N7O13
  • H donors: 10 H acceptors: 12 LogP: 3.74 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCCCCCOc1ccc(cc1)C(=O)N[C@H]1CCCNC(=O)[C@@H]2[C@@H](O)[C@H](CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC1=O)[C@H](O)C)C[C@@H](C2)O)CCc1ccc(cc1)O)[C@H](O)C)C
  • InChi: 1S/C49H71N7O13/c1-5-6-7-8-9-10-24-69-35-20-16-32(17-21-35)43(62)51-36-12-11-23-50-47(66)41-42(61)28(2)26-56(41)49(68)40(30(4)58)54-45(64)37(22-15-31-13-18-33(59)19-14-31)52-46(65)38-25-34(60)27-55(38)48(67)39(29(3)57)53-44(36)63/h13-14,16-21,28-30,34,36-42,57-61H,5-12,15,22-27H2,1-4H3,(H,50,66)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t28-,29+,30+,34+,36-,37-,38-,39-,40-,41-,42-/m0/s1
  • InChiKey: CJFZXXTVNUVFDC-PVWZHFNJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0032 0.0033 0.0309
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Trichomonas vaginalis centrin, putative 0.0026 0.0018 0.0129
Echinococcus granulosus calpain A 0.012 0.0251 0.0241
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.111
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0016 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Schistosoma mansoni calpain-2 (C02 family) 0.0036 0.0042 0.0182
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0047 0.0069 0.0148
Echinococcus multilocularis Zinc finger, PHD finger 0.0054 0.0087 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) myosin regulatory light chain 1 0.0026 0.0018 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0095 0.0188 0.0494
Onchocerca volvulus 0.023 0.0524 0.6785
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0281 0.0652 0.1775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Entamoeba histolytica grainin 2 0.0041 0.0053 0.0585
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0087 0.0202
Trypanosoma cruzi casein kinase II, putative 0.0198 0.0445 0.1239
Trichomonas vaginalis caltractin, putative 0.0026 0.0018 0.0129
Toxoplasma gondii CMGC kinase, CK2 family 0.0198 0.0445 0.6731
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Trypanosoma brucei antigen, putative 0.012 0.0251 0.3681
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0054 0.0087 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0287 0.0666 0.8705
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 1
Trypanosoma brucei glucosidase, putative 0.0047 0.0069 0.0819
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0047 0.0069 0.0148
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0281 0.0652 0.3578
Schistosoma mansoni microtubule-associated protein tau 0.0746 0.1807 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0281 0.0652 0.1841
Toxoplasma gondii FATC domain-containing protein 0.0159 0.0347 0.5192
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0654
Loa Loa (eye worm) hypothetical protein 0.0159 0.0347 0.4536
Trypanosoma brucei Calpain-like protein CALP1.3 0.0036 0.0042 0.0402
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Trichomonas vaginalis centrin, putative 0.0026 0.0018 0.0129
Trichomonas vaginalis maltase-glucoamylase, putative 0.0047 0.0069 0.0922
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0177 0.0392 0.5903
Schistosoma mansoni hypothetical protein 0.0036 0.0042 0.0182
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0054 0.0087 0.0202
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0281 0.0652 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma brucei Calpain-like protein 1.2 0.0036 0.0042 0.0402
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0054 0.0087 0.1957
Onchocerca volvulus 0.0256 0.0589 0.7644
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.2472
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0087 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0402
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.111
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0054 0.0087 0.0433
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0054 0.0087 0.0202
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0033 0.0023
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0054 0.0087 0.0078
Leishmania major phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.0198
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Schistosoma mansoni Mername-AA248 (C02 family) 0.012 0.0251 0.1342
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0281 0.0652 0.1775
Brugia malayi Neuronal calcium sensor family protein 1 0.0026 0.0018 0.0109
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0159 0.0347 0.4469
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Leishmania major hypothetical protein, conserved 0.1467 0.3601 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.0202
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0159 0.0347 0.0338
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0087 0.121
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0281 0.0652 1
Brugia malayi calpain 5 0.0036 0.0042 0.0433
Loa Loa (eye worm) calpain 0.012 0.0251 0.3273
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Echinococcus multilocularis calpain family protein 1, d 0.0234 0.0534 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0087 0.121
Leishmania major hypothetical protein, unknown function 0.0036 0.0042 0.0072
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0036 0.0042 0.0386
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0071
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Loa Loa (eye worm) cathepsin B 0.0095 0.0188 0.2456
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Schistosoma mansoni fkbp-rapamycin associated protein 0.0159 0.0347 0.188
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Loa Loa (eye worm) hypothetical protein 0.0105 0.0213 0.2777
Echinococcus multilocularis neutral alpha glucosidase AB 0.0047 0.0069 0.0059
Trypanosoma cruzi kinesin, putative 0.0084 0.0161 0.0416
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.0765 0.0757
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0054 0.0087 0.0078
Entamoeba histolytica calpain family cysteine protease, putative 0.0036 0.0042 0.0407
Trypanosoma brucei hypothetical protein 0.0036 0.0042 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0332 0.0779 0.077
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0054 0.0087 0.0078
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0026 0.0018 0.0019
Echinococcus multilocularis calpain 5 0.012 0.0251 0.0241
Trypanosoma brucei Casein kinase II 0.0198 0.0445 0.6737
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0896
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.0202
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0033 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.3681
Leishmania major alpha glucosidase II subunit, putative 0.0047 0.0069 0.0146
Leishmania major hypothetical protein, conserved 0.0036 0.0042 0.0072
Trypanosoma cruzi kinesin, putative 0.0084 0.0161 0.0416
Schistosoma mansoni alpha-glucosidase 0.0327 0.0765 0.4207
Schistosoma mansoni hypothetical protein 0.0123 0.0258 0.1382
Trichomonas vaginalis calcium binding protein, putative 0.0026 0.0018 0.0129
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0825
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Schistosoma mansoni calpain (C02 family) 0.012 0.0251 0.1342
Brugia malayi Glycosyl hydrolases family 31 protein 0.0327 0.0765 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Trichomonas vaginalis centrin, putative 0.0026 0.0018 0.0129
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0054 0.0087 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Brugia malayi Myosin regulatory light chain 1 0.0026 0.0018 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.009
Loa Loa (eye worm) hypothetical protein 0.0318 0.0743 0.9705
Echinococcus granulosus Calcium binding protein 0.0026 0.0018 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 0.1841
Loa Loa (eye worm) hypothetical protein 0.0198 0.0445 0.5809
Toxoplasma gondii target of rapamycin (TOR), putative 0.0281 0.0652 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0087 0.121
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Giardia lamblia Cathepsin B precursor 0.0095 0.0188 0.2685
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0026 0.0018 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0047 0.0069 0.0896
Onchocerca volvulus 0.0198 0.0445 0.5719
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0036 0.0042 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0392 0.5955
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0087 0.0078
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0069 0.0148
Schistosoma mansoni calmodulin-related 0.0026 0.0018 0.0046
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0327 0.0765 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 0.1775
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0159 0.0347 0.5203
Brugia malayi calpain 5 0.0084 0.0161 0.2005
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0273 0.3569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0047 0.0069 0.0784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Giardia lamblia Kinase, CMGC CK2 0.0198 0.0445 0.6731
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0123 0.0258 0.0249
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0087 0.121
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.0652 0.8506
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0281 0.0652 0.1841
Onchocerca volvulus 0.0032 0.0033 0.022
Loa Loa (eye worm) hypothetical protein 0.0054 0.0087 0.1138
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Trypanosoma cruzi hypothetical protein, conserved 0.1413 0.3467 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Trypanosoma brucei calpain, putative 0.0036 0.0042 0.0402
Trichomonas vaginalis maltase-glucoamylase, putative 0.0047 0.0069 0.0922
Plasmodium vivax SET domain protein, putative 0.0032 0.0033 0.0733
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.021
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.0666 0.3655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Schistosoma mansoni myosin regulatory light chain 0.0026 0.0018 0.0046
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0054 0.0087 0.1095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0121
Loa Loa (eye worm) hypothetical protein 0.0123 0.0258 0.3366
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.013
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Echinococcus multilocularis casein kinase ii subunit alpha 0.0198 0.0445 0.0436
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0549
Giardia lamblia GTOR 0.0281 0.0652 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0087 0.0433
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Leishmania major phosphatidylinositol kinase related protein, putative 0.0054 0.0087 0.0198
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.0202
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Schistosoma mansoni calpain C (C02 family) 0.012 0.0251 0.1342
Onchocerca volvulus 0.0026 0.0018 0.0019
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0654
Brugia malayi calpain family protein 1 0.0318 0.0743 0.9701
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0281 0.0652 1
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0198 0.0445 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0095 0.0188 0.0479
Echinococcus granulosus casein kinase ii subunit alpha 0.0198 0.0445 0.0436
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0054 0.0087 0.1115
Leishmania major phosphatidylinositol 3-kinase, putative 0.0281 0.0652 0.1775
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0054 0.0087 0.0433
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0047 0.0069 0.07
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0159 0.0347 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0042 0.0509
Echinococcus granulosus cathepsin b 0.0287 0.0666 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0213 0.316
Echinococcus multilocularis cathepsin b 0.0287 0.0666 0.0658
Trypanosoma brucei cysteine peptidase C (CPC) 0.0095 0.0188 0.2697
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0054 0.0087 0.1115
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0281 0.0652 0.0644
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1957
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Brugia malayi Casein kinase II, alpha chain 0.0198 0.0445 0.5761
Schistosoma mansoni myosin regulatory light chain 0.0026 0.0018 0.0046
Echinococcus granulosus calpain 0.012 0.0251 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.0652 0.8506
Brugia malayi calpain D 0.0036 0.0042 0.0433
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0332 0.0779 0.428
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0087 0.0078
Plasmodium falciparum centrin-4 0.0026 0.0018 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0087 0.121
Trypanosoma cruzi calpain cysteine peptidase, putative 0.012 0.0251 0.0676
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0054 0.0087 0.111
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0188 0.2779
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0087 0.121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Echinococcus granulosus cathepsin b 0.0287 0.0666 0.0658
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.0251 0.3681
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0 0.5
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0159 0.0347 0.52
Brugia malayi RasGEF domain containing protein 0.0026 0.0018 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0033 0.013
Echinococcus granulosus programmed cell death protein 0.0041 0.0053 0.0044
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Brugia malayi FAT domain containing protein 0.0123 0.0258 0.3284
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.0666 0.3655
Echinococcus granulosus microtubule associated protein 2 0.0746 0.1807 0.1799
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0281 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0087 0.0433
Schistosoma mansoni calpain-7 (C02 family) 0.012 0.0251 0.1342
Trypanosoma brucei caltractin, putative 0.0041 0.0053 0.0579
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.1957
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.013
Loa Loa (eye worm) phosphatidylinositol kinase 0.0054 0.0087 0.1138
Entamoeba histolytica casein kinase, putative 0.0198 0.0445 0.6739
Giardia lamblia Cathepsin B precursor 0.0095 0.0188 0.2685
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0123 0.0258 0.0249
Echinococcus granulosus Myosin regulatory light chain 0.0026 0.0018 0.0008
Leishmania major phosphatidylinositol kinase, putative 0.0054 0.0087 0.0198
Trichomonas vaginalis calmodulin, putative 0.0041 0.0053 0.0685
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0281 0.0652 0.0644
Echinococcus multilocularis Myosin regulatory light chain 0.0026 0.0018 0.0008
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0402
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0281 0.0652 0.1841
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0177 0.0392 0.591
Entamoeba histolytica grainin 2 0.0026 0.0018 0.0023
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Loa Loa (eye worm) calpain 5 0.0084 0.0161 0.2102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Giardia lamblia Phosphatidylinositol 4-kinase 0.0054 0.0087 0.1095
Trypanosoma cruzi centrin, putative 0.0041 0.0053 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis set domain proteins, putative 0.0256 0.0589 0.9012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0047 0.0069 0.0784
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Echinococcus multilocularis calpain 0.012 0.0251 0.0241
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0281 0.0652 0.3578
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Leishmania major hypothetical protein, unknown function 0.0054 0.0087 0.0198
Onchocerca volvulus 0.0054 0.0087 0.0947
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0054 0.0087 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0213 0.316
Schistosoma mansoni alpha-glucosidase 0.0327 0.0765 0.4207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0281 0.0652 0.8524
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.023 0.0524 0.6852
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0287 0.0666 0.3655
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0159 0.0347 0.0956
Loa Loa (eye worm) calpain family protein 1 0.0318 0.0743 0.9705
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0825
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0105 0.0213 0.0565
Entamoeba histolytica calmodulin, putative 0.0026 0.0018 0.0023
Trypanosoma brucei Calpain-like protein 2 0.0036 0.0042 0.0402
Echinococcus granulosus serine protein kinase ATM 0.0159 0.0347 0.0338
Trichomonas vaginalis calmodulin, putative 0.0026 0.0018 0.0129
Brugia malayi Probable myosin regulatory light chain 0.0026 0.0018 0.0109
Echinococcus granulosus lysosomal alpha glucosidase 0.0327 0.0765 0.0757
Trypanosoma brucei kinesin, putative 0.0084 0.0161 0.2271
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Entamoeba histolytica protein kinase rad3, putative 0.0159 0.0347 0.5203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0229
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0159 0.0347 0.0956
Leishmania major casein kinase II, putative 0.0198 0.0445 0.1196
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0054 0.0087 0.1957
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0054 0.0087 0.111
Trichomonas vaginalis calcium binding protein, putative 0.0041 0.0053 0.0685
Plasmodium vivax hypothetical protein 0.0054 0.0087 0.1957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.0202
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.1957
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0033 0.0237
Leishmania major kinesin, putative 0.0084 0.0161 0.0404
Giardia lamblia Hypothetical protein 0.0054 0.0087 0.1095
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.1115
Schistosoma mansoni myosin light chain 0.0026 0.0018 0.0046
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.0512 0.6684
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0281 0.0652 1
Plasmodium vivax unspecified product 0.0198 0.0445 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.0534 0.698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0332 0.0779 0.077
Entamoeba histolytica hypothetical protein 0.0159 0.0347 0.5203
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0054 0.0087 0.1957
Trypanosoma cruzi centrin-3 0.0041 0.0053 0.0104
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0026 0.0018 0.0019
Trypanosoma brucei Calpain-like protein 1.1 0.0036 0.0042 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0392 0.5955
Plasmodium falciparum calpain 0.0036 0.0042 0.0945
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.009
Trypanosoma cruzi conserved protein 0.0036 0.0042 0.0071
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0402
Echinococcus multilocularis calpain A 0.0332 0.0779 0.077
Schistosoma mansoni hypothetical protein 0.0054 0.0087 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0258 0.3861
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Leishmania major phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.0198
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0825
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0054 0.0087 0.0433
Entamoeba histolytica protein kinase, putative 0.0087 0.0168 0.2389
Brugia malayi calpain 7 0.012 0.0251 0.3191
Leishmania major glycosyl hydrolase-like protein 0.0047 0.0069 0.0146
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.2472
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Echinococcus granulosus programmed cell death protein 6 0.0026 0.0018 0.0008
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Trichomonas vaginalis caltractin, putative 0.0026 0.0018 0.0129
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0287 0.0666 0.1881
Loa Loa (eye worm) calpain D 0.0036 0.0042 0.0549
Echinococcus multilocularis calpain 7 (C02 family) 0.012 0.0251 0.0241
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0087 0.121
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0087 0.121
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0069 0.0148
Schistosoma mansoni alpha glucosidase 0.0047 0.0069 0.033
Schistosoma mansoni eyes absent homolog 0.0095 0.0189 0.1001
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0087 0.1957
Trichomonas vaginalis calpain, putative 0.0036 0.0042 0.0509
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.021
Echinococcus multilocularis programmed cell death protein 0.0041 0.0053 0.0044
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.121
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.009
Onchocerca volvulus 0.0327 0.0765 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Loa Loa (eye worm) calpain family protein 1 0.0234 0.0534 0.698
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0016 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0426
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0054 0.0087 0.121
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0016 0.1849
Echinococcus multilocularis cathepsin b 0.0287 0.0666 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0033 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 0.1841
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0159 0.0347 0.4469
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0273 0.3569
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Trypanosoma brucei cysteine peptidase, putative 0.0036 0.0042 0.0402
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0054 0.0087 0.1095
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0016 1
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Trichomonas vaginalis sucrase-isomaltase, putative 0.0047 0.0069 0.0922
Trichomonas vaginalis calpain, putative 0.0036 0.0042 0.0509
Onchocerca volvulus 0.0054 0.0087 0.0947
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0129
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Brugia malayi hypothetical protein 0.0095 0.0189 0.2379
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.404 1 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.0653 0.8534
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0016 0.1849
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trypanosoma brucei glycosyl hydrolase-like protein 0.0047 0.0069 0.0819
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0229
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.0765 0.0757
Toxoplasma gondii cathepsin B 0.0095 0.0188 0.2685
Loa Loa (eye worm) myosin Light Chain family member 0.0026 0.0018 0.0229
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.111
Echinococcus granulosus calpain 5 0.012 0.0251 0.0241
Brugia malayi calpain family protein 1 0.0318 0.0743 0.9701
Echinococcus granulosus calpain 7 C02 family 0.012 0.0251 0.0241
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0198 0.0445 0.5812
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0654
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Echinococcus multilocularis microtubule associated protein 2 0.0746 0.1807 0.1799
Loa Loa (eye worm) phosphatidylinositol 3 0.0281 0.0652 0.8524
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0016 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0054 0.0087 0.1957
Loa Loa (eye worm) hypothetical protein 0.0177 0.0392 0.5125
Echinococcus multilocularis programmed cell death protein 6 0.0026 0.0018 0.0008
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0159 0.0347 0.188
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0318 0.0743 0.4081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0402
Loa Loa (eye worm) hypothetical protein 0.0054 0.0087 0.1138
Schistosoma mansoni protein kinase 0.0198 0.0445 0.2424
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.0445 0.6739
Trichomonas vaginalis calpain, putative 0.0036 0.0042 0.0509
Echinococcus granulosus calpain A 0.0332 0.0779 0.077
Leishmania major calpain family cysteine protease-like protein 0.0036 0.0042 0.0072
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0036 0.0042 0.0402
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0054 0.0087 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Giardia lamblia Cathepsin B precursor 0.0095 0.0188 0.2685
Echinococcus multilocularis serine protein kinase ATM 0.0159 0.0347 0.0338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0087 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Toxoplasma gondii hypothetical protein 0.0036 0.0042 0.0386
Echinococcus granulosus calcyphosin protein 0.0026 0.0018 0.0008
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0054 0.0087 0.0078
Mycobacterium leprae conserved hypothetical protein 0.0054 0.0087 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.003 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0087 0.121
Echinococcus multilocularis 0.0054 0.0087 0.0078
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.0202
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0087 0.0433
Trypanosoma brucei calpain, putative 0.0036 0.0042 0.0402
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0087 0.121
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0281 0.0652 1
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0402
Brugia malayi MH2 domain containing protein 0.0129 0.0273 0.349
Echinococcus multilocularis Calcium binding protein 0.0026 0.0018 0.0008
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0054 0.0087 0.0078
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0281 0.0652 0.0644
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0281 0.0652 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0188 0.0994
Echinococcus multilocularis hypothetical protein 0.012 0.0251 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Leishmania major calpain protease-like protein 0.0036 0.0042 0.0072
Trichomonas vaginalis hypothetical protein 0.0036 0.0042 0.0509
Trypanosoma brucei centrin-3 0.0041 0.0053 0.0579
Brugia malayi cathepsin B-like cysteine proteinase 0.0287 0.0666 0.8689
Brugia malayi Pre-SET motif family protein 0.0225 0.0512 0.6644
Trypanosoma cruzi centrin, putative 0.0041 0.0053 0.0104
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0877
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0026 0.0018 0.0129
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0281 0.0652 0.1775
Echinococcus multilocularis programmed cell death protein 0.0041 0.0053 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Plasmodium vivax calpain, putative 0.012 0.0251 0.5632
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0071
Schistosoma mansoni calpain-7 (C02 family) 0.012 0.0251 0.1342
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Mycobacterium ulcerans hypothetical protein 0.0026 0.0016 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0084 0.0161 0.2276
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0804
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Plasmodium falciparum casein kinase 2, alpha subunit 0.0198 0.0445 1
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0332 0.0779 0.428
Echinococcus granulosus neutral alpha glucosidase AB 0.0047 0.0069 0.0059
Echinococcus multilocularis calcyphosin protein 0.0026 0.0018 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.0666 0.3655
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0054 0.0087 0.0433
Trichomonas vaginalis kakapo, putative 0.0026 0.0018 0.0129
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Onchocerca volvulus 0.0026 0.0018 0.0019

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3 uM Concentration of the compound inhibiting Candida beta-1,3-glucan synthesis was determined in a Candida albicans cell culture ChEMBL. 1495015
MFC (functional) = 1 ug ml-1 Antifungal activity of the compound on Candida albicans MY1055. ChEMBL. 1495015
MFC (functional) = 2 ug ml-1 Antifungal activity of the compound on Candida albicans MY1208. ChEMBL. 1495015
MFC (functional) = 2 ug ml-1 Antifungal activity of the compound on Candida albicans MY1028. ChEMBL. 1495015

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Candida albicans ChEMBL23 1495015

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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