Detailed information for compound 1758591

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 481.993 | Formula: C22H28ClN3O5S
  • H donors: 3 H acceptors: 4 LogP: 2.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC[C@@H]1Oc2ccc(cc2C(=O)N(C[C@H]1C)[C@@H](CO)C)NS(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C22H28ClN3O5S/c1-14-12-26(15(2)13-27)22(28)19-10-17(6-9-20(19)31-21(14)11-24-3)25-32(29,30)18-7-4-16(23)5-8-18/h4-10,14-15,21,24-25,27H,11-13H2,1-3H3/t14-,15-,21+/m1/s1
  • InChiKey: YYANULOBHCTJTG-PZPWOCDFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0126 0.1521
Brugia malayi Carboxylesterase family protein 0.0023 0.0098 0.0201
Brugia malayi Cytochrome P450 family protein 0.0019 0.0056 0.0114
Onchocerca volvulus 0.0037 0.0262 0.0463
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0699 0.1524
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0232 0.0499
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 0.0548 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0051 0.0105
Brugia malayi hypothetical protein 0.003 0.0175 0.036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0389 0.08
Brugia malayi Bromodomain containing protein 0.0154 0.1603 0.3294
Loa Loa (eye worm) carboxylesterase 0.0023 0.0098 0.0201
Echinococcus multilocularis carboxylesterase 5A 0.0137 0.1407 0.3079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0365 0.0791
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0365 0.0791
Loa Loa (eye worm) hypothetical protein 0.0088 0.0847 0.1741
Plasmodium vivax importin-beta 2, putative 0.0035 0.0232 0.1136
Brugia malayi Amino acid permease family protein 0.0051 0.0418 0.086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0158 0.1648 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0062 0.0548 0.0538
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0126 0.026
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.023 0.0494
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0821 0.9284 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0062 0.0548 0.3111
Brugia malayi Protein kinase domain containing protein 0.0035 0.0231 0.0475
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0098 0.0204
Brugia malayi Trypsin family protein 0.003 0.0175 0.036
Onchocerca volvulus 0.0037 0.0262 0.0463
Echinococcus multilocularis enteropeptidase 0.003 0.0175 0.0374
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Brugia malayi Cytochrome P450 family protein 0.003 0.0175 0.0359
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0056 0.0114
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0051 0.0418 0.086
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.003 0.0175 0.0374
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0201
Toxoplasma gondii hypothetical protein 0.0054 0.0457 0.0694
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Echinococcus granulosus lamin 0.0027 0.0146 0.031
Echinococcus multilocularis glycoprotein Antigen 5 0.003 0.0175 0.0374
Echinococcus granulosus solute carrier family 12 0.0051 0.0418 0.0908
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0015 0.0005 0.000000054364
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4109 0.8445
Loa Loa (eye worm) hypothetical protein 0.0062 0.0548 0.1125
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0175 0.0374
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0103 0.1022 0.4744
Loa Loa (eye worm) hypothetical protein 0.0051 0.0418 0.086
Schistosoma mansoni ap endonuclease 0.0019 0.0051 0.0101
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0156 0.0192
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0201
Onchocerca volvulus 0.0037 0.0262 0.0463
Loa Loa (eye worm) hypothetical protein 0.0302 0.3306 0.6795
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.456 1
Echinococcus granulosus enteropeptidase 0.003 0.0175 0.0374
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0418 0.086
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0062 0.0548 0.3111
Loa Loa (eye worm) hypothetical protein 0.0062 0.0548 0.1125
Onchocerca volvulus 0.0063 0.056 0.0999
Onchocerca volvulus 0.0029 0.0163 0.0286
Echinococcus granulosus cpg binding protein 0.0034 0.0227 0.0488
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0134 0.0276
Schistosoma mansoni hypothetical protein 0.0042 0.0314 0.0678
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0156 0.0192
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0539
Brugia malayi Muscleblind-like protein 0.0302 0.3306 0.6795
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0098 0.0204
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.003 0.0175 0.0374
Brugia malayi Carboxylesterase family protein 0.0023 0.0098 0.0201
Schistosoma mansoni bromodomain containing protein 0.013 0.1329 0.2907
Brugia malayi EGF-like domain containing protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0062 0.0548 0.1125
Entamoeba histolytica hypothetical protein 0.0075 0.0699 0.2032
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0232 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0023 0.0098 0.0051
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) hypothetical protein 0.0044 0.0335 0.0688
Brugia malayi Trypsin family protein 0.0203 0.2173 0.4466
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Echinococcus granulosus geminin 0.0176 0.186 0.4073
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) hypothetical protein 0.0078 0.0728 0.1496
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0103 0.1022 0.1052
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0062 0.0548 0.3111
Entamoeba histolytica Ran family GTPase 0.0026 0.0126 0.0237
Brugia malayi Trypsin family protein 0.003 0.0175 0.036
Schistosoma mansoni hypothetical protein 0.0075 0.0699 0.1524
Plasmodium falciparum importin beta, putative 0.0035 0.0232 0.1136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0146 0.03
Schistosoma mansoni peptidase Clp (S14 family) 0.0158 0.1648 0.3606
Toxoplasma gondii microneme protein MIC17C 0.0037 0.0262 0.0395
Echinococcus multilocularis acetylcholinesterase 0.0137 0.1407 0.3079
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0377 0.0817
Mycobacterium ulcerans hypothetical protein 0.003 0.0175 0.0125
Echinococcus granulosus histone lysine methyltransferase setb 0.0098 0.0958 0.2093
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0126 0.0376
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0134 0.0199
Schistosoma mansoni zinc finger protein 0.0031 0.0189 0.0404
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1497 0.1566
Loa Loa (eye worm) hypothetical protein 0.0203 0.2173 0.4466
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0134 0.0276
Brugia malayi Trypsin family protein 0.003 0.0175 0.036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0958 0.2093
Toxoplasma gondii microneme protein, putative 0.0037 0.0262 0.0395
Trypanosoma cruzi ISWI complex protein 0.0031 0.0189 0.278
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0098 0.0204
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Echinococcus multilocularis musashi 0.0027 0.0146 0.031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0098 0.0204
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0548 0.0538
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0134 0.0276
Onchocerca volvulus 0.0498 0.556 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.1648 0.2521
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0548 0.1192
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0026 0.0134 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0365 0.0791
Brugia malayi amine oxidase, flavin-containing family protein 0.0062 0.0548 0.1125
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0098 0.0204
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0126 0.026
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.003 0.0175 0.0374
Brugia malayi Carboxylesterase family protein 0.0023 0.0098 0.0201
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.003 0.0175 0.0374
Schistosoma mansoni cpg binding protein 0.0029 0.0163 0.0348
Echinococcus granulosus peptidase Clp S14 family 0.0103 0.1022 0.2233
Echinococcus granulosus acetylcholinesterase 0.0137 0.1407 0.3079
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.056 0.1218
Toxoplasma gondii hypothetical protein 0.0037 0.0262 0.0395
Brugia malayi Pre-SET motif family protein 0.0063 0.056 0.115
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.1245 0.2723
Schistosoma mansoni hypothetical protein 0.003 0.0175 0.0374
Onchocerca volvulus 0.003 0.0175 0.0307
Echinococcus multilocularis 0.0062 0.0548 0.1192
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0098 0.0204
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Loa Loa (eye worm) hypothetical protein 0.0051 0.0418 0.086
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0005 0.001
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0377 0.0817
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.324 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.0276
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0562 0.1224
Onchocerca volvulus 0.0023 0.0098 0.0167
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.0276
Schistosoma mansoni lamin 0.0027 0.0146 0.031
Brugia malayi RNA, U transporter 1 0.0099 0.0971 0.1996
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.003 0.0175 0.036
Onchocerca volvulus 0.003 0.0175 0.0307
Toxoplasma gondii microneme protein MIC4 0.0037 0.0262 0.0395
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0457 0.1274
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.324 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0335 0.0688
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0231 0.0497
Onchocerca volvulus 0.0048 0.0389 0.0692
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Brugia malayi hypothetical protein 0.0062 0.0548 0.1125
Mycobacterium ulcerans monoamine oxidase 0.0062 0.0548 0.0499
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0004 0.0008
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0134 0.0199
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0051 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0542 0.0825
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Brugia malayi Importin beta-1 subunit 0.0035 0.0232 0.0477
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0335 0.0688
Onchocerca volvulus 0.0037 0.0262 0.0463
Schistosoma mansoni zinc finger protein 0.0041 0.0308 0.0665
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0026 0.0134 0.0276
Schistosoma mansoni egf-like domain protein 0.0026 0.0134 0.0284
Onchocerca volvulus 0.0037 0.0262 0.0463
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1497 0.1453
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.023 0.0494
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1497 0.8733
Echinococcus multilocularis peptidase Clp (S14 family) 0.0103 0.1022 0.2233
Entamoeba histolytica hypothetical protein 0.0075 0.0699 0.2032
Loa Loa (eye worm) Notch2 0.0015 0.0005 0.001
Schistosoma mansoni survival motor neuron protein 0.0048 0.0389 0.0844
Brugia malayi MH2 domain containing protein 0.0144 0.149 0.3063
Trichomonas vaginalis spcc417.12 protein, putative 0.0023 0.0098 0.0085
Schistosoma mansoni hypothetical protein 0.0411 0.456 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0023 0.0098 0.0047
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.324 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0335 0.0688
Loa Loa (eye worm) hypothetical protein 0.0238 0.2565 0.5272
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) hypothetical protein 0.0137 0.1407 0.2892
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.1245 0.2723
Loa Loa (eye worm) hypothetical protein 0.0035 0.0231 0.0475
Loa Loa (eye worm) hypothetical protein 0.0044 0.0335 0.0688
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0548 0.3111
Toxoplasma gondii PAN/Apple domain-containing protein 0.0037 0.0262 0.0395
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0231 0.3627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0365 0.0791
Schistosoma mansoni amine oxidase 0.0062 0.0548 0.1192
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0156 0.2125
Brugia malayi GCC2 and GCC3 family protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0302 0.3306 0.6795
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0231 0.0347
Schistosoma mansoni gliotactin 0.0023 0.0098 0.0204
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0539
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.1648 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0163 0.0336
Onchocerca volvulus 0.0062 0.0548 0.0977
Leishmania major GTP-binding protein, putative 0.0026 0.0126 0.1521
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0023 0.0098 0.0085
Schistosoma mansoni amine oxidase 0.0062 0.0548 0.1192
Brugia malayi EGF-like domain containing protein 0.0015 0.0005 0.001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.1648 0.1605
Brugia malayi Muscle positioning protein 4 0.0015 0.0005 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.324 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0062 0.0548 0.1192
Plasmodium vivax SET domain protein, putative 0.0063 0.056 0.3187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.1648 0.2521
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0158 0.1648 0.3606
Schistosoma mansoni ap endonuclease 0.0019 0.0051 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Brugia malayi PHD-finger family protein 0.0052 0.0432 0.0889
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2565 0.5621
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0158 0.1648 1
Loa Loa (eye worm) notch protein 0.0015 0.0005 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0231 0.0497
Brugia malayi EGF-like domain containing protein 0.0015 0.0005 0.001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0158 0.1648 1
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0262 0.0395
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0231 0.0497
Toxoplasma gondii PAN domain-containing protein 0.0581 0.6521 1
Entamoeba histolytica hypothetical protein 0.0028 0.0156 0.0331
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0098 0.0204
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0126 0.0267
Brugia malayi Kringle domain containing protein 0.0035 0.0231 0.0475
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0098 0.0051
Onchocerca volvulus 0.0174 0.1829 0.3284
Onchocerca volvulus 0.0037 0.0262 0.0463
Brugia malayi SWIRM domain containing protein 0.0062 0.0548 0.1125
Loa Loa (eye worm) acetylcholinesterase 1 0.0137 0.1407 0.2892
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0175 0.0374
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0062 0.0548 0.0499
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0457 0.2545
Loa Loa (eye worm) hypothetical protein 0.0062 0.0548 0.1125
Echinococcus granulosus importin subunit beta 1 0.0035 0.0232 0.0499
Brugia malayi Carboxylesterase family protein 0.0137 0.1407 0.2892
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0365 0.075
Echinococcus multilocularis geminin 0.0176 0.186 0.4073
Leishmania major hypothetical protein, conserved 0.0031 0.0189 0.278
Onchocerca volvulus Arrow homolog 0.0026 0.0134 0.0233
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) hypothetical protein 0.0044 0.0335 0.0688
Leishmania major importin beta-1 subunit, putative 0.0028 0.0156 0.2125
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Echinococcus granulosus Mastin 0.003 0.0175 0.0374
Brugia malayi EGF-like domain containing protein 0.0015 0.0005 0.001
Onchocerca volvulus 0.0023 0.0098 0.0167
Onchocerca volvulus 0.003 0.0175 0.0307
Echinococcus multilocularis Tolloid protein 1 0.0026 0.0134 0.0284
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0056 0.0005
Brugia malayi Pre-SET motif family protein 0.0437 0.4866 1
Schistosoma mansoni cpg binding protein 0.0034 0.0227 0.0488
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0457 0.2545
Schistosoma mansoni ran 0.0026 0.0126 0.0267
Echinococcus multilocularis Mastin 0.003 0.0175 0.0374
Onchocerca volvulus 0.0027 0.0146 0.0254
Loa Loa (eye worm) hypothetical protein 0.0158 0.1648 0.3386
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.0477
Mycobacterium ulcerans oxidoreductase 0.0062 0.0548 0.0499
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0201
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0056 0.0114
Loa Loa (eye worm) hypothetical protein 0.0098 0.0958 0.1969
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.1648 0.1605
Echinococcus multilocularis snurportin 1 0.0372 0.4109 0.9011
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0548 0.1192
Echinococcus granulosus transmembrane protease serine 3 0.003 0.0175 0.0374
Trichomonas vaginalis ran, putative 0.0026 0.0126 0.0137
Brugia malayi EGF-like domain containing protein 0.0015 0.0005 0.001
Schistosoma mansoni acetylcholinesterase 0.0023 0.0098 0.0204
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2565 0.5621
Schistosoma mansoni hypothetical protein 0.0176 0.186 0.4073
Loa Loa (eye worm) trypsin family protein 0.003 0.0175 0.036
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0056 0.0094
Echinococcus multilocularis protoporphyrinogen oxidase 0.0062 0.0548 0.1192
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0158 0.1648 0.5006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0958 0.2093
Onchocerca volvulus 0.003 0.0175 0.0307
Echinococcus granulosus carboxylesterase 5A 0.0137 0.1407 0.3079
Toxoplasma gondii exonuclease III APE 0.0019 0.0051 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0126 0.4167
Brugia malayi Delta serrate ligand family protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0163 0.0336
Brugia malayi intermediate filament protein 0.0027 0.0146 0.03
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0175 0.0374
Brugia malayi Carboxylesterase family protein 0.0023 0.0098 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.0276
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0231 0.0475
Onchocerca volvulus 0.0023 0.0098 0.0167
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0056 0.0094
Brugia malayi Cytochrome P450 family protein 0.0019 0.0056 0.0114
Echinococcus granulosus snurportin 1 0.0372 0.4109 0.9011
Echinococcus multilocularis neurogenic locus notch protein 0.0015 0.0005 0.000000066303
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0098 0.0204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0365 0.0791
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0231 0.1129
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.023 0.0494
Loa Loa (eye worm) amino acid permease 0.0051 0.0418 0.086
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0056 0.0114
Echinococcus granulosus neuroligin 0.0023 0.0098 0.0204
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0262 0.0395
Loa Loa (eye worm) hypothetical protein 0.0137 0.1407 0.2892
Brugia malayi hypothetical protein 0.0075 0.0699 0.1437
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0539
Echinococcus granulosus zinc finger protein 0.0041 0.0308 0.0665
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Schistosoma mansoni hypothetical protein 0.0372 0.4109 0.9011
Loa Loa (eye worm) hypothetical protein 0.0062 0.0548 0.1125
Loa Loa (eye worm) hypothetical protein 0.0203 0.2173 0.4466
Toxoplasma gondii microneme protein MIC17B 0.0037 0.0262 0.0395
Loa Loa (eye worm) hypothetical protein 0.0051 0.0418 0.086
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0671 0.1463
Toxoplasma gondii microneme protein MIC17A 0.0037 0.0262 0.0395
Echinococcus multilocularis laminin 0.0026 0.0134 0.0284
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0203 0.2173 0.476
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0098 0.0958 0.2093
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.036
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0146 0.03
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0539
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.023 0.0494
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.056 0.1218
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0526 0.1144
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Echinococcus granulosus Tolloid protein 1 0.0026 0.0134 0.0284
Loa Loa (eye worm) hypothetical protein 0.0144 0.1484 0.305
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0262 0.0539
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0026 0.0134 0.0276
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0158 0.1648 0.3606
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0288
Toxoplasma gondii PAN domain-containing protein 0.0581 0.6521 1
Echinococcus granulosus acetylcholinesterase 0.0137 0.1407 0.3079
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.1648 1
Brugia malayi Carboxylesterase family protein 0.0137 0.1407 0.2892
Echinococcus multilocularis cpg binding protein 0.0034 0.0227 0.0488
Loa Loa (eye worm) hypothetical protein 0.0051 0.0418 0.086
Schistosoma mansoni ran 0.0026 0.0126 0.0267
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.036
Schistosoma mansoni importin beta-1 0.0035 0.0232 0.0499
Onchocerca volvulus 0.0037 0.0262 0.0463
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0051 0.0101
Toxoplasma gondii subtilisin SUB12 0.0037 0.0262 0.0395
Brugia malayi EGF-like domain containing protein 0.0015 0.0005 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.149 0.3063
Brugia malayi Bromodomain containing protein 0.0078 0.0726 0.1493
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0064 0.0568 0.0864
Echinococcus granulosus glycoprotein Antigen 5 0.003 0.0175 0.0374
Echinococcus granulosus laminin 0.0026 0.0134 0.0284
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0231 0.1129
Loa Loa (eye worm) carboxylesterase 0.0137 0.1407 0.2892
Schistosoma mansoni hypothetical protein 0.0031 0.0189 0.0404
Echinococcus granulosus intermediate filament protein 0.0027 0.0146 0.031
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0015 0.0005 0.001
Toxoplasma gondii histone lysine-specific demethylase 0.0062 0.0548 0.0833
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.0276
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Echinococcus multilocularis muscleblind protein 1 0.0302 0.3306 0.7248
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0146 0.03
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0037 0.0262 0.0395
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0062 0.0548 0.1192
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0005 0.001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0062 0.0548 0.3111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0699 0.1524
Loa Loa (eye worm) hypothetical protein 0.0051 0.0418 0.086
Brugia malayi Trypsin-like protease protein 5 0.003 0.0175 0.036
Echinococcus multilocularis acetylcholinesterase 0.0137 0.1407 0.3079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Loa Loa (eye worm) hypothetical protein 0.0083 0.0783 0.161
Onchocerca volvulus 0.0203 0.2173 0.3903
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0126 0.0187
Echinococcus granulosus muscleblind protein 0.0302 0.3306 0.7248
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0548 0.3111
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0314 0.0645
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0201
Onchocerca volvulus 0.0023 0.0098 0.0167
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0126 0.0267
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Entamoeba histolytica hypothetical protein 0.0075 0.0699 0.2032
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.003 0.0175 0.0374
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0137 0.1407 0.3079
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0158 0.1648 1
Schistosoma mansoni hypothetical protein 0.0176 0.186 0.4073
Onchocerca volvulus 0.0037 0.0262 0.0463
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0203 0.2173 0.476
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0377 0.0817
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.03
Onchocerca volvulus 0.0037 0.0262 0.0463
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.149 0.3063
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0098 0.0204
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0062 0.0548 0.076
Brugia malayi Cadherin domain containing protein 0.0015 0.0005 0.001
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0262 0.0395
Onchocerca volvulus Neurogenic locus notch homolog 0.0015 0.0005 0.000000054364
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0232 0.0349
Onchocerca volvulus 0.0037 0.0262 0.0463
Trypanosoma cruzi ISWI complex protein 0.0031 0.0189 0.278
Echinococcus multilocularis transmembrane protease serine 3 0.003 0.0175 0.0374
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0051 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0365 0.0791
Trypanosoma brucei ISWI complex protein 0.0031 0.0189 0.7616
Brugia malayi Cadherin domain containing protein 0.0015 0.0005 0.001
Entamoeba histolytica hypothetical protein 0.0075 0.0699 0.2032
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0098 0.0204
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0699 0.1524
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Echinococcus granulosus dnaJ subfamily B 0.0411 0.456 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0146 0.031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0365 0.075
Leishmania major cytochrome p450-like protein 0.0019 0.0056 0.0094
Echinococcus multilocularis solute carrier family 12 0.0051 0.0418 0.0908
Onchocerca volvulus 0.003 0.0175 0.0307
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0539
Echinococcus multilocularis lamin dm0 0.0027 0.0146 0.031
Schistosoma mansoni lamin 0.0027 0.0146 0.031
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0126 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0365 0.0791
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0056 0.0257
Brugia malayi Calcium binding EGF domain containing protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0103 0.1022 0.1052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0134 0.0276
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0156 0.0192
Loa Loa (eye worm) hypothetical protein 0.0051 0.0418 0.086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Schistosoma mansoni hypothetical protein 0.0048 0.0389 0.0844
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0671 0.1463
Toxoplasma gondii hypothetical protein 0.0037 0.0262 0.0395
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0098 0.0201
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0175 0.0359
Onchocerca volvulus 0.0035 0.0231 0.0407
Schistosoma mansoni hypothetical protein 0.003 0.0175 0.0374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.056 0.1218
Echinococcus granulosus lamin dm0 0.0027 0.0146 0.031
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0175 0.0374
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0098 0.0051
Onchocerca volvulus 0.0037 0.0262 0.0463
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0884 1 1
Echinococcus multilocularis zinc finger protein 0.0041 0.0308 0.0665
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0175 0.0374
Brugia malayi hypothetical protein 0.0238 0.2565 0.5272
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Echinococcus multilocularis lamin 0.0027 0.0146 0.031
Loa Loa (eye worm) carboxylesterase 0.0023 0.0098 0.0201
Echinococcus multilocularis muscleblind protein 0.0302 0.3306 0.7248
Leishmania major UDP-galactopyranose mutase 0.0062 0.0548 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0232 1
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0262 0.0539
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0126 0.1521
Leishmania major hypothetical protein, conserved 0.0035 0.0231 0.3627
Brugia malayi Fibulin-1 precursor 0.0026 0.0134 0.0276
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 0.0548 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0335 0.0688
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0262 0.0395
Plasmodium falciparum protoporphyrinogen oxidase 0.0062 0.0548 0.3111
Brugia malayi PAN domain containing protein 0.0037 0.0262 0.0539
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0175 0.0374
Onchocerca volvulus 0.0023 0.0098 0.0167
Brugia malayi notch-like transmembrane receptor 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.036
Loa Loa (eye worm) hypothetical protein 0.0062 0.0548 0.1125
Echinococcus multilocularis neuroligin 0.0023 0.0098 0.0204
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.4866 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0126 0.0473
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0098 0.0204
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.0539
Echinococcus granulosus neurogenic locus notch protein 0.0015 0.0005 0.000000066303
Brugia malayi EGF-like domain containing protein 0.0015 0.0005 0.001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0051 0.0142
Onchocerca volvulus 0.0027 0.0146 0.0254
Mycobacterium ulcerans dehydrogenase 0.0062 0.0548 0.0499
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.324 0.5789
Echinococcus multilocularis fibrillin 1 0.0026 0.0134 0.0284
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.001
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0244 0.0502
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.056 0.0852
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0051 0.0418 0.0908
Brugia malayi hypothetical protein 0.0023 0.0098 0.0201
Trichomonas vaginalis set domain proteins, putative 0.0498 0.556 1
Brugia malayi Probable ClpP-like protease 0.0158 0.1648 0.3386
Schistosoma mansoni cpg binding protein 0.0034 0.0227 0.0488
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0062 0.0548 0.1192

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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