TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 341.81 | Formula: C15H16ClNO4S
H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(OCCOc1ccc(cc1Cl)/C=C/1\SC(=O)NC1=O)C
InChi: 1S/C15H16ClNO4S/c1-9(2)20-5-6-21-12-4-3-10(7-11(12)16)8-13-14(18)17-15(19)22-13/h3-4,7-9H,5-6H2,1-2H3,(H,17,18,19)/b13-8-
InChiKey: DIPDCPKDIYHJPG-JYRVWZFOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	axis inhibition protein axin	0.0129	0.1095	0.1095
Schistosoma mansoni	hypothetical protein	0.0025	0.0171	0.0171
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Echinococcus multilocularis	Pleckstrin y	0.0025	0.0171	0.0144
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1008	0.8856	0.8853
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0025	0.0171	0.0144
Loa Loa (eye worm)	PXA domain-containing protein	0.0129	0.1095	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0265	0.0222
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0025	0.0171	0.0602
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1095	0.5028
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0236	0.0192
Echinococcus granulosus	beta 1 syntrophin	0.0025	0.0171	0.0144
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Brugia malayi	Variant SH3 domain containing protein	0.0025	0.0171	0.0602
Schistosoma mansoni	zinc finger protein	0.0025	0.0171	0.0171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.035	0.035
Brugia malayi	hypothetical protein	0.0129	0.1095	0.495
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Brugia malayi	PXA domain containing protein	0.0129	0.1095	0.495
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.0199	0.0171
Echinococcus granulosus	Regulator of G protein signaling 20	0.0129	0.1095	0.107
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0028	0.0199	0.0924
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Toxoplasma gondii	ABC1 family protein	0.0036	0.0265	0.3161
Echinococcus granulosus	Pleckstrin y	0.0025	0.0171	0.0144
Echinococcus multilocularis	oxysterol binding protein 3	0.0025	0.0171	0.0144
Entamoeba histolytica	protein kinase, putative	0.0028	0.0199	0.0298
Echinococcus multilocularis	pdz domain containing protein	0.0025	0.0171	0.0144
Echinococcus multilocularis	expressed protein	0.0129	0.1095	0.107
Leishmania major	folate/biopterin transporter, putative	0.0028	0.0199	0.2924
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.022	0.1898	0.1861
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0098	0.0071
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0199	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1095	0.1055
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0199	0.0199
Entamoeba histolytica	hypothetical protein	0.0028	0.0199	0.0298
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0251	0.2168	0.2133
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0199	0.0298
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0025	0.0171	0.0144
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0.0171	0.074
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0025	0.0171	0.0144
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.035	0.0323
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Echinococcus multilocularis	dnaJ subfamily B	0.0431	0.3765	0.3747
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0265	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0219	0.0175
Schistosoma mansoni	myotubularin-related protein	0.0025	0.0171	0.0171
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0025	0.0171	0.0144
Schistosoma mansoni	hypothetical protein	0.0025	0.0171	0.0171
Leishmania major	hypothetical protein, conserved	0.0036	0.0265	1
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0129	0.1095	0.495
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0236	0.0236
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Entamoeba histolytica	protein kinase, putative	0.0028	0.0199	0.0298
Echinococcus granulosus	dnaJ subfamily B	0.0431	0.3765	0.3747
Trypanosoma brucei	protein kinase, putative	0.0028	0.0199	0.2924
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0265	0.5
Schistosoma mansoni	zinc finger protein	0.0025	0.0171	0.0171
Loa Loa (eye worm)	RGS-3 protein	0.0129	0.1095	0.1055
Echinococcus granulosus	pleckstrin y domain containing family A	0.0025	0.0171	0.0144
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0265	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Echinococcus granulosus	muscleblind protein	0.0152	0.1298	0.1273
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0121	0.1024	0.0984
Schistosoma mansoni	regulator of G protein signaling	0.0129	0.1095	0.1095
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Entamoeba histolytica	protein kinase, putative	0.0028	0.0199	0.0298
Echinococcus multilocularis	axis inhibition protein axin	0.0129	0.1095	0.107
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.035	0.0323
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0025	0.0171	0.0144
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0025	0.0171	0.0127
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0028	0.0199	0.0155
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0265	0.1176
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0129	0.1095	0.495
Brugia malayi	regulator of G-protein signaling egl-10	0.0129	0.1095	0.495
Brugia malayi	Cadps2 protein	0.0025	0.0171	0.0602
Schistosoma mansoni	hypothetical protein	0.0431	0.3765	0.3765
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Schistosoma mansoni	cpg binding protein	0.0032	0.0234	0.0234
Brugia malayi	Pre-SET motif family protein	0.022	0.1898	0.8729
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0265	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0129	0.1095	0.107
Brugia malayi	Plekhf2 protein	0.0025	0.0171	0.0602
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0265	0.1176
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0025	0.0171	0.0171
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0236	0.0236
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Loa Loa (eye worm)	PH domain-containing protein	0.0025	0.0171	0.0127
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0265	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0269	0.1062
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0025	0.0171	0.0127
Echinococcus granulosus	oxysterol binding protein 9	0.0025	0.0171	0.0144
Echinococcus multilocularis	actin binding protein anillin	0.0025	0.0171	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1095	0.5028
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Entamoeba histolytica	hypothetical protein	0.0028	0.0199	0.0298
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1095	0.1055
Schistosoma mansoni	hypothetical protein	0.0036	0.0269	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Schistosoma mansoni	oxysterol-binding protein 1	0.0025	0.0171	0.0171
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Schistosoma mansoni	oxysterol-binding protein 1	0.0025	0.0171	0.0171
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0199	0.0298
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0028	0.0199	0.2924
Onchocerca volvulus		0.0251	0.2166	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0416	0.0373
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0121	0.1024	0.0999
Echinococcus multilocularis	muscleblind protein	0.0152	0.1298	0.1273
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Schistosoma mansoni	regulator of G protein signaling	0.0129	0.1095	0.1095
Echinococcus multilocularis	cytohesin 1	0.0025	0.0171	0.0144
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0025	0.0171	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1095	0.5028
Trypanosoma cruzi	NIMA-related kinase, putative	0.0028	0.0199	0.2924
Trichomonas vaginalis	kinesin light chain, putative	0.0025	0.0171	0.074
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1095	0.1055
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0098	0.0071
Echinococcus granulosus	axis inhibition protein axin	0.0129	0.1095	0.107
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Entamoeba histolytica	protein kinase, putative	0.0028	0.0199	0.0298
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0236	0.0236
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0236	0.0236
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1298	0.1259
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0098	0.0071
Onchocerca volvulus		0.0036	0.0265	0.0472
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0236	0.0208
Brugia malayi	beta-lactamase family protein	0.0036	0.0265	0.1045
Loa Loa (eye worm)	syntrophin-1	0.0025	0.0171	0.0127
Brugia malayi	TBC domain containing protein	0.0025	0.0171	0.0602
Loa Loa (eye worm)	uncoordinated protein 104	0.0025	0.0171	0.0127
Echinococcus granulosus	oxysterol binding protein 3	0.0025	0.0171	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0236	0.0208
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0025	0.0171	0.0144
Echinococcus granulosus	GRB2 associated binding protein 3	0.0025	0.0171	0.0144
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0265	0.0265
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0025	0.0171	0.0144
Brugia malayi	Protein kinase domain containing protein	0.0028	0.0199	0.0732
Brugia malayi	hypothetical protein	0.0129	0.1095	0.495
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1137	1	1
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0121	0.1024	0.0999
Schistosoma mansoni	hypothetical protein	0.0025	0.0171	0.0171
Schistosoma mansoni	rho gtpase activating protein	0.0025	0.0171	0.0171
Schistosoma mansoni	serine/threonine protein kinase	0.1137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0199	0.0298
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0098	0.0259
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Loa Loa (eye worm)	Plekhf2 protein	0.0025	0.0171	0.0127
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0028	0.0199	0.2924
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1095	0.5028
Echinococcus granulosus	Pleckstrin y	0.0025	0.0171	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0265	0.0222
Leishmania major	protein kinase, putative	0.0028	0.0199	0.2924
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0098	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0025	0.0171	0.0144
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0265	0.1176
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0265	1
Schistosoma mansoni	regulator of G protein signaling	0.0129	0.1095	0.1095
Echinococcus granulosus	regulator of G protein signaling 7	0.0129	0.1095	0.107
Schistosoma mansoni	serine/threonine protein kinase	0.0251	0.2168	0.2168
Echinococcus multilocularis	regulator of G protein signaling 3	0.0129	0.1095	0.107
Trichomonas vaginalis	esterase, putative	0.0036	0.0265	0.1176
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0025	0.0171	0.074
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.035	0.035
Brugia malayi	Oxysterol-binding protein	0.0025	0.0171	0.0602
Brugia malayi	CXXC zinc finger family protein	0.003	0.0219	0.0827
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0028	0.0199	0.0867
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0028	0.0199	1
Entamoeba histolytica	p21-activated kinase	0.0028	0.0199	0.0298
Brugia malayi	Dynamin	0.0025	0.0171	0.0602
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1095	0.5028
Schistosoma mansoni	regulator of G protein signaling	0.0129	0.1095	0.1095
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0025	0.0171	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1095	0.1055
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0416	0.1755
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.0199	0.2924
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Echinococcus multilocularis	regulator of G protein signaling	0.0129	0.1095	0.107
Leishmania major	protein kinase, putative	0.0028	0.0199	0.2924
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0265	0.1176
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0129	0.1095	0.107
Echinococcus granulosus	expressed protein	0.0129	0.1095	0.107
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.035	0.0323
Echinococcus multilocularis	axis inhibition protein axin	0.0129	0.1095	0.107
Entamoeba histolytica	protein kinase, putative	0.0028	0.0199	0.0298
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.035	0.1445
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Entamoeba histolytica	protein kinase, putative	0.0028	0.0199	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1095	0.1055
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0265	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0265	0.0222
Echinococcus multilocularis	dynamin 1	0.0025	0.0171	0.0144
Schistosoma mansoni	hypothetical protein	0.0017	0.0098	0.0098
Trichomonas vaginalis	centaurin beta, putative	0.0025	0.0171	0.074
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0025	0.0171	0.074
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0025	0.0171	0.0171
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0129	0.1095	0.1095
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0025	0.0171	0.074
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0025	0.0171	0.0602
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0129	0.1095	0.107
Schistosoma mansoni	hypothetical protein	0.0025	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.0199	0.2924
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Schistosoma mansoni	growth factor receptor-bound protein	0.0025	0.0171	0.0171
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0028	0.0199	0.2924
Brugia malayi	Oxysterol binding protein	0.0025	0.0171	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0025	0.0171	0.0144
Echinococcus granulosus	myotubularin protein 13	0.0025	0.0171	0.0144
Echinococcus multilocularis	beta 1 syntrophin	0.0025	0.0171	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Schistosoma mansoni	vav2	0.0025	0.0171	0.0171
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Entamoeba histolytica	hypothetical protein	0.0129	0.1095	1
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0025	0.0171	0.0127
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0028	0.0199	0.2924
Trypanosoma cruzi	NIMA-related kinase, putative	0.0028	0.0199	0.2924
Echinococcus multilocularis	regulator of G protein signaling 7	0.0129	0.1095	0.107
Brugia malayi	Syntrophin-1	0.0025	0.0171	0.0602
Schistosoma mansoni	hypothetical protein	0.0017	0.0098	0.0098
Onchocerca volvulus		0.0036	0.0265	0.0472
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0265	0.0222
Schistosoma mansoni	syntrophin	0.0025	0.0171	0.0171
Loa Loa (eye worm)	oxysterol binding protein	0.0025	0.0171	0.0127
Echinococcus multilocularis	Pleckstrin y	0.0025	0.0171	0.0144
Brugia malayi	beta-lactamase family protein	0.0036	0.0265	0.1045
Echinococcus granulosus	regulator of G protein signaling 7	0.0129	0.1095	0.107
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0236	0.0208
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Echinococcus granulosus	GPCR family 2	0.0017	0.0098	0.0071
Trichomonas vaginalis	alpha chimerin, putative	0.0025	0.0171	0.074
Trichomonas vaginalis	centaurin gamma, putative	0.0025	0.0171	0.074
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.035	0.0307
Schistosoma mansoni	serine/threonine protein kinase	0.1137	1	1
Trichomonas vaginalis	protein transport protein sec7, putative	0.0025	0.0171	0.074
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0098	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Brugia malayi	Cytohesin 3	0.0025	0.0171	0.0602
Echinococcus multilocularis	oxysterol binding protein 9	0.0025	0.0171	0.0144
Echinococcus granulosus	Pleckstrin y	0.0025	0.0171	0.0144
Brugia malayi	regulator of G-protein signaling rgs-7	0.0129	0.1095	0.495
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0121	0.1024	0.4617
Echinococcus granulosus	oxysterol binding protein 1	0.0025	0.0171	0.0144
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0025	0.0171	0.00000012621
Echinococcus granulosus	Rho GTPase activating protein 24	0.0025	0.0171	0.0144
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0028	0.0199	0.2924
Brugia malayi	A-kinase anchor protein 10, precursor	0.0129	0.1095	0.495
Brugia malayi	MAX-1A	0.0025	0.0171	0.0602
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0265	1
Loa Loa (eye worm)	cytohesin 3	0.0025	0.0171	0.0127
Plasmodium vivax	SET domain protein, putative	0.0032	0.0236	0.6826
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0025	0.0171	0.0144
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.1298	0.1273
Trichomonas vaginalis	centaurin/arf, putative	0.0025	0.0171	0.074
Trichomonas vaginalis	centaurin alpha, putative	0.0025	0.0171	0.074
Schistosoma mansoni	hypothetical protein	0.0025	0.0171	0.0171
Loa Loa (eye worm)	rho-GTPase-activating	0.0025	0.0171	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0025	0.0171	0.0171
Trichomonas vaginalis	centaurin/arf, putative	0.0025	0.0171	0.074
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0236	0.2158
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Trichomonas vaginalis	set domain proteins, putative	0.0251	0.2166	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0469	1
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Brugia malayi	Variant SH3 domain containing protein	0.0025	0.0171	0.0602
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0265	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Schistosoma mansoni	z-protein (S1r protein)	0.0129	0.1095	0.1095
Entamoeba histolytica	hypothetical protein	0.0129	0.1095	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0129	0.1095	0.107
Onchocerca volvulus		0.0036	0.0265	0.0472
Brugia malayi	beta-lactamase	0.0036	0.0265	0.1045
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0025	0.0171	0.0144
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0251	0.2168	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0265	0.0238
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0129	0.1095	0.1055
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0265	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0199	0.0298
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0044	0.0016
Schistosoma mansoni	hypothetical protein	0.0017	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0028	0.0199	0.2924
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0025	0.0171	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0028	0.0199	0.0867
Schistosoma mansoni	hypothetical protein	0.0017	0.0098	0.0098
Brugia malayi	PH domain containing protein	0.0025	0.0171	0.0602
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0028	0.0199	0.2924
Onchocerca volvulus		0.0032	0.0236	0.0322
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Brugia malayi	Uncoordinated protein 104	0.0025	0.0171	0.0602
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0025	0.0171	0.0144
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0265	0.5
Schistosoma mansoni	cpg binding protein	0.003	0.0219	0.0219
Echinococcus granulosus	cpg binding protein	0.0032	0.0234	0.0207
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0028	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Schistosoma mansoni	goodpasture antigen-binding protein	0.0025	0.0171	0.0171
Brugia malayi	PXA domain containing protein	0.0129	0.1095	0.495
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Onchocerca volvulus		0.003	0.0219	0.024
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0025	0.0171	0.0144
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0265	0.0238
Schistosoma mansoni	goodpasture antigen-binding protein	0.0025	0.0171	0.0171
Echinococcus multilocularis	myotubularin protein 13	0.0025	0.0171	0.0144
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0121	0.1024	0.0984
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.053	0.053
Echinococcus multilocularis	cpg binding protein	0.0032	0.0234	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0269	0.0226
Schistosoma mansoni	dynamin	0.0025	0.0171	0.0171
Echinococcus granulosus	calcium dependent secretion activator 1	0.0025	0.0171	0.0144
Schistosoma mansoni	centaurin alpha	0.0025	0.0171	0.0171
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0416	0.1755
Brugia malayi	probable spectrin beta chain	0.0025	0.0171	0.0602
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0129	0.1095	0.1095
Toxoplasma gondii	protein kinase domain-containing protein	0.0028	0.0199	0.0924
Schistosoma mansoni	regulator of G protein signaling	0.0129	0.1095	0.1095
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0028	0.0199	0.2924
Schistosoma mansoni	axis inhibition protein axin	0.0129	0.1095	0.1095
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0025	0.0171	0.0144
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0129	0.1095	0.107
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.035	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1095	0.1055
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0028	0.0199	0.2924
Mycobacterium ulcerans	lipase LipD	0.0036	0.0265	0.5
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0025	0.0171	0.0171
Brugia malayi	Muscleblind-like protein	0.0152	0.1298	0.5904
Brugia malayi	hypothetical protein	0.0025	0.0171	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0265	0.0222
Echinococcus granulosus	cytohesin 1	0.0025	0.0171	0.0144
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0265	1
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1137	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0098	0.0071
Schistosoma mansoni	dynamin	0.0025	0.0171	0.0171
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0098	0.0259
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1008	0.8856	0.8853
Trypanosoma cruzi	Protein kinase B	0.0028	0.0199	0.2924
Schistosoma mansoni	cpg binding protein	0.0032	0.0234	0.0234
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.0199	0.0171
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0025	0.0171	0.0144
Echinococcus granulosus	regulator of G protein signaling 3	0.0129	0.1095	0.107
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0028	0.0199	0.2924
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.1958	1
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0265	0.0222
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0025	0.0171	0.0144
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.0199	0.0298
Echinococcus multilocularis	oxysterol binding protein 1	0.0025	0.0171	0.0144
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Entamoeba histolytica	hypothetical protein	0.0129	0.1095	1
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Echinococcus granulosus	pdz domain containing protein	0.0025	0.0171	0.0144
Echinococcus multilocularis	Oxysterol binding protein 11	0.0025	0.0171	0.0144
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0044	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0416	0.0373
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0025	0.0171	0.0144
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0129	0.1095	0.5028
Echinococcus multilocularis	regulator of G protein signaling 7	0.0129	0.1095	0.107
Echinococcus granulosus	DCC interacting protein 13 beta	0.0025	0.0171	0.0144
Trichomonas vaginalis	hypothetical protein	0.0025	0.0171	0.074
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0025	0.0171	0.0127
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0219	0.0192
Trichomonas vaginalis	protein transport protein sec7, putative	0.0025	0.0171	0.074
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0028	0.0199	0.2924
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0028	0.0199	0.2924
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0025	0.0171	0.0144
Leishmania major	serine/threonine-protein kinase a, putative	0.0028	0.0199	0.2924
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0265	0.0222
Echinococcus granulosus	axis inhibition protein axin	0.0129	0.1095	0.107
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1298	0.1259
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.0199	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0098	0.0054
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0025	0.0171	0.0144
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0025	0.0171	0.074
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0025	0.0171	0.0602
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0028	0.0199	0.2924
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0265	0.0265
Brugia malayi	Pre-SET motif family protein	0.0032	0.0236	0.0905
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.035	0.035
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0129	0.1095	0.1095
Brugia malayi	Pleckstrin Homology Domain	0.0025	0.0171	0.0602
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0171	0.0127
Entamoeba histolytica	protein kinase, putative	0.0028	0.0199	0.0298
Echinococcus granulosus	Oxysterol binding protein 11	0.0025	0.0171	0.0144
Echinococcus granulosus	dynamin 1	0.0025	0.0171	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0171	0.074
Brugia malayi	Dynamin	0.0025	0.0171	0.0602
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0028	0.0199	0.2924
Echinococcus multilocularis	Pleckstrin y	0.0025	0.0171	0.0144
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0028	0.0199	0.2924
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0.0171	0.074
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0265	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.1095	0.5028

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.738 uM	Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectrophotometric analysis	ChEMBL.	23791868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2414141

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1771109