Detailed information for compound 178866

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.543 | Formula: C26H22N4O2S
  • H donors: 3 H acceptors: 3 LogP: 5.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1ccc(c(c1)C)Nc1c2ccccc2nc2c1cccc2
  • InChi: 1S/C26H22N4O2S/c1-17-16-19(30-33(31,32)20-13-10-18(27)11-14-20)12-15-23(17)29-26-21-6-2-4-8-24(21)28-25-9-5-3-7-22(25)26/h2-16,30H,27H2,1H3,(H,28,29)
  • InChiKey: PBUPIEJJDSGAMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.011 0.0253
Plasmodium falciparum serine repeat antigen 6 0.003 0.011 0.1544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.2588 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0117 0.0137
Schistosoma mansoni ferritin light chain 0.0035 0.0147 0.0278
Echinococcus multilocularis acetylcholinesterase 0.0478 0.3849 0.5719
Loa Loa (eye worm) Smad1 0.0033 0.0131 0.0245
Onchocerca volvulus 0.019 0.1444 0.4355
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.011 0.0205
Brugia malayi Carboxylesterase family protein 0.0478 0.3849 0.9665
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0212 0.0376
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.051 0.1445
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0022
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.2445 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0068 0.0168
Giardia lamblia Cathepsin L-like protease 0.003 0.011 0.0331
Mycobacterium ulcerans lipase LipD 0.019 0.1444 1
Schistosoma mansoni apoferritin-2 0.0035 0.0147 0.0278
Loa Loa (eye worm) hypothetical protein 0.0249 0.1941 0.3861
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0221 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0331 0.0305
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0318 0.0873
Echinococcus multilocularis smad 0.0033 0.0131 0.0159
Echinococcus multilocularis prolyl endopeptidase 0.041 0.3285 0.4875
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0374 0.2986 0.4428
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Schistosoma mansoni acetylcholinesterase 0.0081 0.0531 0.1047
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0248 0.0872
Echinococcus granulosus cathepsin b 0.0422 0.3383 0.6734
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.0495
Onchocerca volvulus 0.0078 0.0509 0.1485
Plasmodium falciparum serine repeat antigen 2 0.003 0.011 0.1544
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0198 0.0258
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.051 0.1445
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0052 0.0082
Plasmodium falciparum peptidase, putative 0.0055 0.0318 0.5286
Echinococcus granulosus neuropeptide s receptor 0.0497 0.401 0.7989
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0617 0.5013 1
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0509 0.1888
Schistosoma mansoni apoferritin-2 0.0035 0.0147 0.0278
Loa Loa (eye worm) TAR-binding protein 0.007 0.0442 0.0867
Plasmodium vivax vivapain-2 0.0078 0.0509 0.3398
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Schistosoma mansoni neuroligin 3 (S09 family) 0.0081 0.0531 0.1047
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.058 0.3902
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0355 0.2823 0.2804
Giardia lamblia Cysteine protease 0.003 0.011 0.0331
Loa Loa (eye worm) carboxylesterase 0.0478 0.3849 0.7675
Schistosoma mansoni hypothetical protein 0.0115 0.0821 0.1627
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0168 0.056
Echinococcus granulosus acylamino acid releasing enzyme 0.0055 0.0318 0.0588
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0365 0.2906 0.7295
Brugia malayi Animal haem peroxidase family protein 0.0256 0.1994 0.5006
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0033
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.003 0.011 0.0205
Leishmania major GTP-binding protein, putative 0.0043 0.0212 0.0567
Loa Loa (eye worm) MH2 domain-containing protein 0.0482 0.3887 0.775
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0117 0.0219
Onchocerca volvulus 0.003 0.011 0.0261
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0386 0.0359
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.003 0.011 0.0202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.011 0.0331
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.0147 0.0119
Toxoplasma gondii cathepsin CPL 0.0078 0.0509 0.1485
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0318 0.1143
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0495
Schistosoma mansoni ran 0.0043 0.0212 0.041
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.124 0.4739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0117 0.0282
Entamoeba histolytica cysteine proteinase, putative 0.003 0.011 0.0331
Onchocerca volvulus 0.0081 0.0531 0.1554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0117 0.0216
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0678 0.2546
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0117 0.0137
Plasmodium falciparum cysteine proteinase falcipain 1 0.003 0.011 0.1544
Schistosoma mansoni hypothetical protein 0.0249 0.1941 0.3863
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0374 0.2986 0.5951
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.0365 0.2906 0.5789
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0067 0.0419 0.0393
Mycobacterium tuberculosis Conserved protein 0.019 0.1444 0.1421
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0052 0.013
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.003 0.011 0.0205
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0213 0.1639 0.3236
Loa Loa (eye worm) hypothetical protein 0.0319 0.2524 0.5026
Brugia malayi beta-lactamase family protein 0.019 0.1444 0.3627
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0117 0.0293
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0678 0.2546
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0495
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0022
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.041 0.3285 1
Echinococcus granulosus protein cereblon 0.0319 0.2524 0.501
Schistosoma mansoni hypothetical protein 0.0319 0.2524 0.5028
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0099 0.0687 0.203
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.003 0.011 0.1544
Brugia malayi MH2 domain containing protein 0.0482 0.3887 0.9758
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0318 0.1143
Echinococcus multilocularis expressed protein 0.0035 0.0147 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0678 0.2546
Loa Loa (eye worm) blistered cuticle protein 3 0.0256 0.1994 0.3967
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0117 0.0219
Schistosoma mansoni smad1 5 8 and 0.0033 0.0131 0.0248
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.0389
Brugia malayi RNA, U transporter 1 0.0164 0.123 0.3089
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0047 0.0087
Echinococcus multilocularis protein patched 0.0044 0.0224 0.0297
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.011 0.0277
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Plasmodium falciparum importin beta, putative 0.0058 0.034 0.5675
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.1471 0.2922
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0099 0.0687 0.2024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.1444 0.5537
Schistosoma mansoni hypothetical protein 0.0364 0.2896 0.577
Brugia malayi ecdysteroid receptor 0.0031 0.0117 0.0293
Echinococcus multilocularis muscleblind protein 0.0155 0.1154 0.1689
Brugia malayi nuclear receptor NHR-88 0.0031 0.0117 0.0293
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1314 0.5029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0419 0.3355 0.498
Giardia lamblia Fructose-bisphosphate aldolase 0.0327 0.2588 1
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.1186 0.2329
Brugia malayi Papain family cysteine protease containing protein 0.003 0.011 0.0276
Schistosoma mansoni cathepsin S (C01 family) 0.003 0.011 0.0205
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.0531 0.1047
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.1964 0.4932
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0202
Brugia malayi Probable ClpP-like protease 0.0087 0.058 0.1457
Echinococcus multilocularis cathepsin L 0.003 0.011 0.0127
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0171 0.1288 0.3886
Schistosoma mansoni thyroid hormone receptor 0.0419 0.3355 0.6689
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1444 0.5537
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0509 0.0724
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1444 0.4227
Brugia malayi Papain family cysteine protease containing protein 0.003 0.011 0.0276
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0212 0.0558
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.003 0.011 0.1544
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0478 0.3849 0.7676
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.003 0.011 0.0331
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0052 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.124 0.4739
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0678 0.1701
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0318 0.1143
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.0075
Loa Loa (eye worm) hypothetical protein 0.0078 0.0509 0.1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0081 0.0531 0.1015
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0249 0.0872
Brugia malayi Smad1 0.0033 0.0131 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0052 0.0099
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.6712 1
Brugia malayi nuclear hormone receptor 0.0031 0.0117 0.0293
Loa Loa (eye worm) hypothetical protein 0.0078 0.0509 0.1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0212 0.028
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0422 0.3383 1
Brugia malayi CHE-14 protein 0.0044 0.0224 0.0562
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0117 0.0219
Loa Loa (eye worm) RecQ helicase 0.0023 0.0047 0.0077
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0446 0.1253
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.011 0.0331
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0127 0.01
Giardia lamblia Cathepsin B precursor 0.0151 0.1122 0.4281
Echinococcus multilocularis thioredoxin glutathione reductase 0.0067 0.0419 0.059
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.1079 0.1577
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.1186 0.2979
Echinococcus multilocularis cysteine protease 0.0078 0.0509 0.0724
Loa Loa (eye worm) hypothetical protein 0.019 0.1444 0.2869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0106 0.0391
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0158 0.0402
Onchocerca volvulus Peroxidasin homolog 0.0256 0.1994 0.604
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0331 0.0614
Schistosoma mansoni alpha-glucosidase 0.0137 0.1001 0.1986
Brugia malayi Serine carboxypeptidase S28 family protein 0.002 0.0025 0.0063
Mycobacterium tuberculosis Carboxylesterase LipT 0.0081 0.0531 0.0505
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0131 0.0213
Schistosoma mansoni hypothetical protein 0.0042 0.0211 0.0407
Onchocerca volvulus 0.0081 0.0531 0.1554
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0446 0.0843
Plasmodium falciparum thioredoxin reductase 0.0067 0.0419 0.7103
Echinococcus granulosus GPCR family 2 0.0115 0.0821 0.1597
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.003 0.011 0.1544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Trypanosoma cruzi cysteine protease, putative 0.003 0.011 0.0253
Plasmodium falciparum glutathione reductase 0.0067 0.0419 0.7103
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0386 0.0969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0481
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.034 0.0981
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0052 0.0497
Schistosoma mansoni hypothetical protein 0.0364 0.2896 0.577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Echinococcus multilocularis acylamino acid releasing enzyme 0.0055 0.0318 0.0438
Loa Loa (eye worm) hypothetical protein 0.0054 0.0307 0.0595
Entamoeba histolytica cysteine proteinase 2 0.003 0.011 0.0331
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.003 0.011 0.0582
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0249 0.048
Trypanosoma cruzi cruzipain precursor, putative 0.0078 0.0509 0.1441
Schistosoma mansoni cathepsin B (C01 family) 0.003 0.011 0.0205
Schistosoma mansoni importin beta-1 0.0058 0.034 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0249 0.0872
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.011 0.0205
Leishmania major mitochondrial DNA polymerase beta 0.031 0.2445 0.7421
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.2445 0.7204
Loa Loa (eye worm) transcription factor SMAD2 0.0482 0.3887 0.775
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.124 0.4739
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0446 0.0629
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0078 0.0509 0.1441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0052 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0117 0.0293
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0212 0.059
Schistosoma mansoni hypothetical protein 0.0617 0.5013 1
Giardia lamblia GTOR 0.0047 0.0249 0.0872
Loa Loa (eye worm) hypothetical protein 0.0078 0.0509 0.1
Echinococcus granulosus cathepsin L 0.003 0.011 0.017
Entamoeba histolytica hypothetical protein 0.0154 0.1147 0.4378
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0678 0.2546
Leishmania major importin beta-1 subunit, putative 0.0047 0.0248 0.0679
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0495
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0027 0.001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0117 0.0137
Giardia lamblia Cathepsin L precursor 0.003 0.011 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.003 0.011 0.0331
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.003 0.011 0.0331
Schistosoma mansoni cathepsin C 0.003 0.011 0.0205
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Entamoeba histolytica hypothetical protein 0.0154 0.1147 0.4378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Schistosoma mansoni tar DNA-binding protein 0.007 0.0442 0.0869
Brugia malayi MH1 domain containing protein 0.0033 0.0131 0.033
Loa Loa (eye worm) cysteine protease 0.0078 0.0509 0.1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0117 0.0184
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0509 0.1888
Echinococcus multilocularis geminin 0.0364 0.2896 0.4293
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.011 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1964 0.7566
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0052 0.0104
Echinococcus granulosus cathepsin l cysteine peptidase 0.0078 0.0509 0.097
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0331 0.2006
Schistosoma mansoni alpha glucosidase 0.0035 0.0152 0.0289
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0000056351
Brugia malayi Muscleblind-like protein 0.0155 0.1154 0.2898
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0117 0.0137
Echinococcus multilocularis carboxylesterase 5A 0.0478 0.3849 0.5719
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0131 0.0245
Brugia malayi hypothetical protein 0.0154 0.1147 0.288
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0131 0.0159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.1471 0.2899
Onchocerca volvulus 0.0078 0.0509 0.1485
Giardia lamblia Hypothetical protein 0.003 0.011 0.0331
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0148 0.0378
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0052 0.0075
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0213 0.1639 0.326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0117 0.0216
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0509 0.1003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.0531 0.1047
Loa Loa (eye worm) hypothetical protein 0.0339 0.2687 0.5352
Brugia malayi hypothetical protein 0.0044 0.0225 0.0566
Echinococcus granulosus cathepsin L 0.003 0.011 0.017
Plasmodium vivax unspecified product 0.003 0.011 0.0582
Giardia lamblia Cathepsin L-like protease 0.003 0.011 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Entamoeba histolytica Ran family GTPase 0.0043 0.0212 0.0731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Giardia lamblia Cysteine protease 0.003 0.011 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0678 0.1339
Brugia malayi latrophilin 2 splice variant baaae 0.0249 0.1941 0.4873
Trypanosoma brucei trypanothione reductase 0.0067 0.0419 0.1224
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Giardia lamblia Cathepsin B precursor 0.0151 0.1122 0.4281
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0117 0.0293
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0387 0.3095 0.4591
Schistosoma mansoni ap endonuclease 0.002 0.0027 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.1471 0.2924
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0224 0.0776
Echinococcus granulosus importin subunit beta 1 0.0058 0.034 0.0631
Giardia lamblia Dipeptidyl-peptidase I precursor 0.003 0.011 0.0331
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0055 0.0318 0.0899
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.1045
Brugia malayi Carboxylesterase family protein 0.0081 0.0531 0.1334
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0171 0.1288 0.1265
Giardia lamblia Dipeptidyl-peptidase I precursor 0.003 0.011 0.0331
Brugia malayi fibroinase precursor 0.003 0.011 0.0276
Plasmodium vivax glutathione reductase, putative 0.0067 0.0419 0.2765
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.03 0.082
Brugia malayi follicle stimulating hormone receptor 0.0494 0.3983 1
Brugia malayi Carboxylesterase family protein 0.0081 0.0531 0.1334
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.058 0.0831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.1471 0.2924
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.0147 0.084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.1444 0.2871
Loa Loa (eye worm) hypothetical protein 0.0044 0.0224 0.043
Onchocerca volvulus 0.0081 0.0531 0.1554
Schistosoma mansoni tar DNA-binding protein 0.007 0.0442 0.0869
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0055 0.0318 0.0914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1964 0.7566
Onchocerca volvulus 0.0031 0.0117 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0191 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0318 0.1143
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0099 0.0687 0.2043
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0212 0.3383
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0033
Echinococcus granulosus expressed conserved protein 0.0096 0.066 0.1274
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0509 0.1441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0068 0.0169
Giardia lamblia Cathepsin B precursor 0.0151 0.1122 0.4281
Toxoplasma gondii ABC1 family protein 0.019 0.1444 0.4355
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.058 0.1114
Echinococcus multilocularis importin subunit beta 1 0.0058 0.034 0.0471
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0035 0.0147 0.2153
Echinococcus multilocularis cathepsin L 0.003 0.011 0.0127
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0386 0.2529
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.0821 0.1191
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0318 0.1143
Trypanosoma brucei hypothetical protein, conserved 0.019 0.1444 0.4364
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0117 0.0184
Brugia malayi cathepsin B-like cysteine proteinase 0.0422 0.3383 0.8495
Brugia malayi Blistered cuticle protein 3 0.0256 0.1994 0.5006
Mycobacterium ulcerans esterase/lipase LipP 0.019 0.1444 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0117 0.0184
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0212 0.0407
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0158 0.052
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Brugia malayi hypothetical protein 0.0078 0.051 0.1281
Toxoplasma gondii cathepsin CPC2 0.003 0.011 0.0261
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0249 0.0334
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0027 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0117 0.0293
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0152 0.0495
Giardia lamblia Kinase, PLK 0.0098 0.0678 0.2546
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0224 0.0399
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0169 0.0428
Loa Loa (eye worm) hypothetical protein 0.0155 0.1154 0.2289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0678 0.2546
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0078 0.0509 0.8716
Entamoeba histolytica hypothetical protein, conserved 0.0319 0.2524 0.9748
Giardia lamblia Cysteine protease 0.003 0.011 0.0331
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0712 0.1378
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0117 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0318 0.0873
Brugia malayi Animal haem peroxidase family protein 0.0256 0.1994 0.5006
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.124 0.4739
Loa Loa (eye worm) animal heme peroxidase 0.0256 0.1994 0.3967
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.011 0.0331
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Echinococcus granulosus smad 0.0033 0.0131 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.011 0.0331
Echinococcus granulosus cathepsin b 0.0422 0.3383 0.6734
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1186 0.1737
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.019 0.1444 1
Schistosoma mansoni smad 0.0033 0.0131 0.0248
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0678 0.0976
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0318 0.1143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0151 0.1122 0.3362
Loa Loa (eye worm) carboxylesterase 0.0081 0.0531 0.1045
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0117 0.0282
Brugia malayi Inositol-1 0.0036 0.0158 0.0397
Giardia lamblia Cathepsin L precursor 0.003 0.011 0.0331
Plasmodium falciparum serine repeat antigen 3 0.003 0.011 0.1544
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Echinococcus granulosus muscleblind protein 0.0155 0.1154 0.2264
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.1191 0.8182
Mycobacterium tuberculosis Probable peptidase 0.0171 0.1288 0.1265
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.058 0.3796
Onchocerca volvulus 0.0303 0.2389 0.7253
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.0147 0.084
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0052 0.0099
Echinococcus granulosus neuroligin 0.0081 0.0531 0.1015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0117 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Brugia malayi beta-lactamase 0.019 0.1444 0.3627
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0052 0.0497
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.1964 0.3908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Treponema pallidum fructose-bisphosphate aldolase 0.0327 0.2588 1
Plasmodium falciparum thioredoxin reductase 0.0023 0.0052 0.0497
Brugia malayi MH2 domain containing protein 0.0033 0.0131 0.033
Loa Loa (eye worm) prolyl oligopeptidase 0.0055 0.0318 0.0618
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.122 0.1196
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.011 0.0582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Schistosoma mansoni tar DNA-binding protein 0.007 0.0442 0.0869
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.003 0.011 0.0582
Mycobacterium leprae conserved hypothetical protein 0.019 0.1444 1
Onchocerca volvulus Cathepsin F homolog 0.0078 0.0509 0.1485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0117 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.1045
Giardia lamblia Cysteine protease 0.003 0.011 0.0331
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0678 0.1337
Schistosoma mansoni hypothetical protein 0.0042 0.0211 0.0407
Giardia lamblia Cathepsin B precursor 0.003 0.011 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.008
Echinococcus granulosus cathepsin l1 0.0078 0.0509 0.097
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0509 0.1485
Mycobacterium ulcerans beta-lactamase 0.019 0.1444 1
Brugia malayi Animal haem peroxidase family protein 0.0256 0.1994 0.5006
Mycobacterium leprae Probable lipase LipE 0.019 0.1444 1
Loa Loa (eye worm) glutathione reductase 0.0067 0.0419 0.082
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0117 0.0293
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.1191 0.8213
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1964 0.7566
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0509 0.0724
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0154 0.1147 0.225
Schistosoma mansoni smad1 5 8 and 0.0033 0.0131 0.0248
Trypanosoma brucei cysteine peptidase C (CPC) 0.0151 0.1122 0.3378
Onchocerca volvulus 0.0256 0.1994 0.604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0481
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.051 0.1503
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.041 0.3285 0.6548
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0171 0.1288 0.3762
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.1471 0.2162
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0318 0.1143
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.003 0.011 0.0582
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1964 0.7566
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.011 0.0331
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.011 0.0205
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0509 0.1485
Trypanosoma brucei prolyl endopeptidase 0.041 0.3285 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0495
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.058 0.1145
Onchocerca volvulus Protein cereblon homolog 0.0319 0.2524 0.7666
Echinococcus granulosus cathepsin L cysteine proteinase 0.0078 0.0509 0.097
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0198 0.0346
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0117 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0678 0.2546
Schistosoma mansoni patched 1 0.0044 0.0224 0.0433
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0078 0.0509 0.1
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0202
Brugia malayi Calcitonin receptor-like protein seb-1 0.0365 0.2906 0.7295
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0117 0.0137
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0422 0.3383 0.6745
Mycobacterium tuberculosis Conserved protein 0.019 0.1444 0.1421
Echinococcus granulosus snurportin 1 0.0617 0.5013 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.124 0.4739
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0099 0.0687 0.1358
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0052 0.0024
Echinococcus granulosus prolyl endopeptidase 0.041 0.3285 0.6535
Schistosoma mansoni hypothetical protein 0.0115 0.0821 0.1627
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0249 0.0701
Brugia malayi hypothetical protein 0.0081 0.0531 0.1334
Trypanosoma cruzi oligopeptidase b 0.0171 0.1288 0.3762
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0678 0.2546
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0117 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0117 0.0184
Giardia lamblia Hypothetical protein 0.003 0.011 0.0331
Brugia malayi cathepsin L-like precursor 0.0078 0.0509 0.1278
Trypanosoma cruzi trypanothione reductase, putative 0.0067 0.0419 0.1174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0117 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0027 0.0061
Leishmania major cysteine peptidase A (CPA) 0.0078 0.0509 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0509 0.1888
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0089 0.0248
Toxoplasma gondii exonuclease III APE 0.002 0.0027 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Onchocerca volvulus 0.0081 0.0531 0.1554
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0494 0.3983 0.7942
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Echinococcus granulosus geminin 0.0364 0.2896 0.5755
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0263 0.0929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0481
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0249 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0257
Plasmodium vivax thioredoxin reductase, putative 0.0067 0.0419 0.2765
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.011 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.124 0.4739
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0386 0.0757
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0131 0.0159
Echinococcus granulosus neuropeptide receptor A26 0.0497 0.401 0.7989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0386 0.11
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0678 0.2546
Giardia lamblia Cathepsin L precursor 0.003 0.011 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.011 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0117 0.0216
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.0821 0.1191
Onchocerca volvulus 0.0078 0.0509 0.1485
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0318 0.0799
Echinococcus multilocularis cysteine protease 0.0078 0.0509 0.0724
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0202
Mycobacterium tuberculosis Conserved protein 0.019 0.1444 0.1421
Schistosoma mansoni ferritin 0.0035 0.0147 0.0278
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0365 0.2906 0.5789
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.002 0.0025 0.0036
Brugia malayi Peroxidasin 0.0256 0.1994 0.5006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0509 0.0724
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0117 0.0184
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0678 0.1996
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.1045
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0131 0.0245
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0033
Loa Loa (eye worm) hypothetical protein 0.019 0.1444 0.2869
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0387 0.3095 0.6155
Toxoplasma gondii preprocathepsin c precursor, putative 0.003 0.011 0.0261
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0152 0.0381
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0248 0.0665
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0221 0.0583
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0213 0.1639 0.2414
Entamoeba histolytica hypothetical protein 0.0047 0.0248 0.0872
Echinococcus multilocularis tar DNA binding protein 0.007 0.0442 0.0624
Onchocerca volvulus 0.0078 0.0509 0.1485
Echinococcus granulosus cysteine protease 0.003 0.011 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0249 0.0872
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.0821 0.1597
Schistosoma mansoni hypothetical protein 0.0115 0.0821 0.1627
Onchocerca volvulus 0.0078 0.0509 0.1485
Brugia malayi TAR-binding protein 0.007 0.0442 0.1111
Brugia malayi Thioredoxin reductase 0.0067 0.0419 0.1053
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0158 0.052
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0152 0.0495
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0117 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.1314 0.5029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.1471 0.2162
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.1045
Loa Loa (eye worm) fibroinase 0.0078 0.0509 0.1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.058 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.124 0.4739
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0263 0.0929
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0117 0.0137
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0117 0.0184
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0131 0.0248
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0152 0.0378
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0027 0.001
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0154 0.1147 0.1678
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0052 0.0439
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0422 0.3383 0.6745
Echinococcus multilocularis ferritin 0.0035 0.0147 0.0182
Echinococcus multilocularis Smad4 0.0033 0.0131 0.0159
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.1045
Echinococcus multilocularis expressed conserved protein 0.0096 0.066 0.095
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0131 0.0213
Schistosoma mansoni kinase 0.005 0.0274 0.0533
Trichomonas vaginalis ran, putative 0.0043 0.0212 0.0731
Brugia malayi Cathepsin L-like precursor 0.0078 0.0509 0.1278
Plasmodium vivax vivapain-3 0.003 0.011 0.0582
Plasmodium falciparum serine repeat antigen 9 0.003 0.011 0.1544
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0171 0.1288 0.8899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0509 0.1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.003 0.011 0.0331
Onchocerca volvulus Peroxidase homolog 0.0256 0.1994 0.604
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0052 0.004
Trypanosoma brucei polo-like protein kinase 0.0098 0.0678 0.2015
Brugia malayi cahepsin L-like non-peptiedase homolog 0.003 0.011 0.0276
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0055 0.0318 0.0621
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0117 0.0293
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0052 0.0171
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0106 0.0307
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0249 0.0679
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0509 0.1888
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.019 0.1444 0.3627
Echinococcus multilocularis acetylcholinesterase 0.0478 0.3849 0.5719
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0081 0.0531 0.0757
Onchocerca volvulus 0.0078 0.0509 0.1485
Schistosoma mansoni gliotactin 0.0081 0.0531 0.1047
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0712 0.2681
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0047 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1964 0.7566
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0446 0.1284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0481
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.011 0.0205
Schistosoma mansoni inositol monophosphatase 0.0036 0.0158 0.0302
Schistosoma mansoni Smad4 0.0033 0.0131 0.0248
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0117 0.0184
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.011 0.0253
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0446 0.1641
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0509 0.1888
Schistosoma mansoni tar DNA-binding protein 0.007 0.0442 0.0869
Echinococcus multilocularis snurportin 1 0.0617 0.5013 0.7459
Entamoeba histolytica hypothetical protein 0.0154 0.1147 0.4378
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.003 0.011 0.0582
Loa Loa (eye worm) carboxylesterase 0.0081 0.0531 0.1045
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0509 0.1003
Loa Loa (eye worm) RNA binding protein 0.007 0.0442 0.0867
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0446 0.0876
Leishmania major hypothetical protein, conserved 0.019 0.1444 0.435
Echinococcus granulosus BC026374 protein S09 family 0.0081 0.0531 0.1015
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0169 0.0457
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0446 0.1119
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.011 0.0331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.1471 0.2899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.008
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.0075
Entamoeba histolytica cysteine protease, putative 0.0078 0.0509 0.1888
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0331 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0168 0.056
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.051 0.1489
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Schistosoma mansoni hypothetical protein 0.0154 0.1147 0.2278
Brugia malayi prolyl oligopeptidase family protein 0.0099 0.0687 0.1724
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.019 0.1444 0.2869
Echinococcus granulosus para nitrobenzyl esterase 0.0081 0.0531 0.1015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0052 0.0171
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0152 0.0286
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0117 0.0137
Loa Loa (eye worm) acetylcholinesterase 1 0.0478 0.3849 0.7675
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.011 0.0582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Brugia malayi Carboxylesterase family protein 0.0081 0.0531 0.1334
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0127 0.0538
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.058 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1082 0.3236
Echinococcus granulosus peroxidasin 0.0256 0.1994 0.3947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0249 0.0872
Toxoplasma gondii cathepsin B 0.0151 0.1122 0.3367
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0052 0.008
Brugia malayi hypothetical protein 0.0319 0.2524 0.6337
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1444 0.4227
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0152 0.0495
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0052 0.0439
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0202
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0158 0.0923
Onchocerca volvulus Chorion peroxidase homolog 0.0256 0.1994 0.604
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0111 0.0336
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0678 0.1943
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0221 0.0616
Brugia malayi glutathione reductase 0.0067 0.0419 0.1053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0068 0.0169
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.124 0.3726
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.011 0.0202
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0152 0.0495
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1444 0.5537
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.011 0.0202
Echinococcus granulosus Dipeptidyl peptidase 9 0.0099 0.0687 0.1327
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.1471 0.3693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.011 0.0331
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0158 0.052
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0117 0.0219
Plasmodium vivax hypothetical protein, conserved 0.019 0.1444 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0442 0.0867
Mycobacterium tuberculosis Probable conserved lipoprotein 0.019 0.1444 0.1421
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Loa Loa (eye worm) animal heme peroxidase 0.0256 0.1994 0.3967
Echinococcus multilocularis cathepsin b 0.0422 0.3383 0.5023
Echinococcus multilocularis neuroligin 0.0081 0.0531 0.0757
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0158 0.0409
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0331 0.0458
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.1191 0.1167
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0712 0.1788
Loa Loa (eye worm) hypothetical protein 0.0115 0.0821 0.1624
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0052 0.0024
Brugia malayi steroid hormone receptor 0.0031 0.0117 0.0293
Toxoplasma gondii hypothetical protein 0.0055 0.0318 0.0899
Brugia malayi Papain family cysteine protease containing protein 0.003 0.011 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0303 0.2389 0.4757
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0027 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.011 0.0253
Echinococcus multilocularis neuropeptide receptor A26 0.0497 0.401 0.5959
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0052 0.0054
Echinococcus multilocularis protein cereblon 0.0319 0.2524 0.3737
Echinococcus multilocularis BC026374 protein (S09 family) 0.0081 0.0531 0.0757
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0202
Brugia malayi prolyl oligopeptidase family protein 0.0213 0.1639 0.4115
Mycobacterium ulcerans carboxylesterase, LipT 0.0081 0.0531 0.3557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0481
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0117 0.0293
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0106 0.0555
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.0821 0.2063
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0117 0.0219
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.011 0.0582
Schistosoma mansoni transcription factor LCR-F1 0.0154 0.1147 0.2278
Loa Loa (eye worm) hypothetical protein 0.0478 0.3849 0.7675
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.041 0.3285 0.6548
Toxoplasma gondii hypothetical protein 0.003 0.0106 0.0249
Plasmodium falciparum serine repeat antigen 5 0.003 0.011 0.1544
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.035 0.0683
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.003 0.011 0.0331
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.034 0.0981
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.1444 0.5537
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0224 0.043
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0678 0.1308
Echinococcus multilocularis neuropeptide s receptor 0.0497 0.401 0.5959
Schistosoma mansoni coup transcription factor 0.0031 0.0117 0.0219
Trypanosoma cruzi oligopeptidase b 0.0171 0.1288 0.3762
Onchocerca volvulus Cathepsin L homolog 0.003 0.011 0.0261
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.015 0.025
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0152 0.0495
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0052 0.008
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0117 0.0216
Brugia malayi Papain family cysteine protease containing protein 0.003 0.011 0.0276
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0171 0.1288 0.3872
Schistosoma mansoni hypothetical protein 0.0115 0.0821 0.1627
Schistosoma mansoni ferritin light chain 0.0035 0.0147 0.0278
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.0531 0.1047
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.058 0.2159
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0318 0.2051
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.003 0.011 0.0582
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0027 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.011 0.0205
Echinococcus multilocularis para nitrobenzyl esterase 0.0081 0.0531 0.0757
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0171 0.1288 0.888
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Mycobacterium tuberculosis Probable lipase LipD 0.019 0.1444 0.1421
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0318 0.1143
Schistosoma mansoni hypothetical protein 0.0042 0.0211 0.0407
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.003 0.011 0.0582
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0386 0.054
Schistosoma mansoni tar DNA-binding protein 0.007 0.0442 0.0869
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0117 0.0219
Echinococcus granulosus tar DNA binding protein 0.007 0.0442 0.0837
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0117 0.0184
Echinococcus granulosus cathepsin L cysteine protease 0.003 0.011 0.017
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0158 0.0199
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.1045
Onchocerca volvulus 0.0081 0.0531 0.1554
Giardia lamblia Encystation-specific protease 0.003 0.011 0.0331
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0422 0.3383 0.6745
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0678 0.2002
Trypanosoma cruzi prolyl endopeptidase 0.041 0.3285 0.9706
Leishmania major oligopeptidase b 0.0171 0.1288 0.3872
Loa Loa (eye worm) hypothetical protein 0.0078 0.0509 0.1
Loa Loa (eye worm) ctsf protein 0.0078 0.0509 0.1
Echinococcus multilocularis peroxidasin 0.0256 0.1994 0.2944
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0117 0.0293
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0171 0.1288 0.3762
Brugia malayi Carboxylesterase family protein 0.0081 0.0531 0.1334
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.1444 0.2871
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0509 0.1441
Loa Loa (eye worm) hypothetical protein 0.0102 0.0712 0.1406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0168 0.056
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0212 0.0731
Schistosoma mansoni hypothetical protein 0.0042 0.0211 0.0407
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0117 0.0216
Trichomonas vaginalis spcc417.12 protein, putative 0.0081 0.0531 0.1976
Loa Loa (eye worm) hypothetical protein 0.041 0.3285 0.6547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0509 0.1441
Schistosoma mansoni alpha-glucosidase 0.0137 0.1001 0.1986
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.058 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0081 0.0531 0.1976
Echinococcus multilocularis GPCR, family 2 0.0115 0.0821 0.1191
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0033
Brugia malayi Importin beta-1 subunit 0.0058 0.034 0.0853
Schistosoma mansoni peroxidasin 0.0256 0.1994 0.3969
Toxoplasma gondii prolyl endopeptidase 0.041 0.3285 1
Brugia malayi Carboxylesterase family protein 0.0478 0.3849 0.9665
Treponema pallidum bacterioferrin (TpF1) 0.0035 0.0147 0.0465
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1122 0.2228
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967
Echinococcus granulosus acetylcholinesterase 0.0478 0.3849 0.7667
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.011 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0089 0.0248
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1082 0.3146
Giardia lamblia Dipeptidyl-peptidase I precursor 0.003 0.011 0.0331
Schistosoma mansoni smad1 5 8 and 0.0033 0.0131 0.0248
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0052 0.0099
Loa Loa (eye worm) hypothetical protein 0.0044 0.0225 0.0433
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.2588 1
Plasmodium falciparum serine repeat antigen 1 0.003 0.011 0.1544
Loa Loa (eye worm) hypothetical protein 0.0055 0.0318 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.012 0.0369
Trypanosoma brucei oligopeptidase b 0.0171 0.1288 0.3886
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0212 0.1304
Loa Loa (eye worm) cathepsin B 0.0151 0.1122 0.2226
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.1122 0.3267
Entamoeba histolytica cysteine proteinase, putative 0.003 0.011 0.0331
Schistosoma mansoni hypothetical protein 0.0035 0.015 0.0285
Brugia malayi Papain family cysteine protease containing protein 0.003 0.011 0.0276
Brugia malayi prolyl oligopeptidase family protein 0.041 0.3285 0.8247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0213 0.1639 0.4951
Giardia lamblia Cathepsin B precursor 0.003 0.011 0.0331
Giardia lamblia Cathepsin B precursor 0.003 0.011 0.0331
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.051 0.8738
Toxoplasma gondii cathepsin CPC1 0.003 0.011 0.0261
Brugia malayi Latrophilin receptor protein 2 0.0115 0.0821 0.2063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0117 0.0293
Entamoeba histolytica cysteine proteinase, putative 0.003 0.011 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0148 0.0481
Plasmodium falciparum glutathione reductase 0.0023 0.0052 0.0497
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0117 0.0293
Trypanosoma brucei glucosidase, putative 0.0035 0.0152 0.0405
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0099 0.0687 0.197
Brugia malayi Cathepsin L-like cysteine proteinase 0.0078 0.0509 0.1278
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0442 0.1111
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.051 0.3407
Schistosoma mansoni ferritin 0.0035 0.0147 0.0278
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0052 0.0024
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.058 0.3902
Onchocerca volvulus Peroxidasin homolog 0.0256 0.1994 0.604
Schistosoma mansoni thyroid hormone receptor 0.0419 0.3355 0.6689
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0117 0.0219
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0117 0.0219
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0202
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0035 0.0147 0.0681
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0249 0.0701
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0386 0.0723
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0099 0.0687 0.099
Entamoeba histolytica hypothetical protein 0.0154 0.1147 0.4378
Loa Loa (eye worm) hypothetical protein 0.0087 0.058 0.1143
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0052 0.0104
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0678 0.1943
Plasmodium falciparum serine repeat antigen 4 0.003 0.011 0.1544
Giardia lamblia Cathepsin L precursor 0.003 0.011 0.0331
Loa Loa (eye worm) animal heme peroxidase 0.0256 0.1994 0.3967
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0249 0.0666
Mycobacterium tuberculosis Probable esterase LipL 0.019 0.1444 0.1421
Onchocerca volvulus 0.019 0.1444 0.4355
Echinococcus multilocularis protein dispatched 1 0.005 0.0276 0.0375
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0106 0.1475
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1154 0.1689
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.011 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0068 0.0169
Echinococcus granulosus carboxylesterase 5A 0.0478 0.3849 0.7667
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0055 0.0318 0.1143
Plasmodium falciparum serine repeat antigen 8 0.003 0.011 0.1544
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Schistosoma mansoni ap endonuclease 0.002 0.0027 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.003 0.011 0.0331
Onchocerca volvulus 0.019 0.1444 0.4355
Entamoeba histolytica cysteine proteinase 1, putative 0.003 0.011 0.0331
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.1186 0.2354
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0042 0.0069
Loa Loa (eye worm) hypothetical protein 0.019 0.1444 0.2869
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.058 0.1704
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0318 0.1143
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0055 0.0318 0.0621
Loa Loa (eye worm) animal heme peroxidase 0.0256 0.1994 0.3967
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0422 0.3383 0.6745
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.011 0.0205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Echinococcus granulosus ferritin 0.0035 0.0147 0.0244
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.019 0.1444 0.1421
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.019 0.1444 0.1421
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0152 0.019
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0249 0.0482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.1471 0.2924
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0509 0.1003
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0117 0.0219
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Loa Loa (eye worm) inositol-1 0.0036 0.0158 0.0299
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.011 0.0205
Plasmodium falciparum serine repeat antigen 7 0.003 0.011 0.1544
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0052 0.0171
Onchocerca volvulus Dual oxidase homolog 0.0256 0.1994 0.604
Trichomonas vaginalis ferritin, putative 0.0035 0.0147 0.0474
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.058 0.1704
Schistosoma mansoni ferritin 0.0035 0.0147 0.0278
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.011 0.0205
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0027 0.0038
Brugia malayi Animal haem peroxidase family protein 0.0256 0.1994 0.5006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0221 0.0583
Plasmodium falciparum cysteine proteinase falcipain 3 0.0078 0.0509 0.8716
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.051 0.8738
Schistosoma mansoni BC026374 protein (S09 family) 0.0081 0.0531 0.1047
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.011 0.0276
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0047 0.0118
Loa Loa (eye worm) hypothetical protein 0.0058 0.034 0.0662
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0027 0.0007
Onchocerca volvulus Prolyl endopeptidase homolog 0.041 0.3285 1
Schistosoma mansoni ferritin 0.0035 0.0147 0.0278
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0025 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0099 0.0687 0.197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0216
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0725 0.1435
Mycobacterium ulcerans hypothetical protein 0.0163 0.122 0.8415
Onchocerca volvulus 0.0256 0.1994 0.604
Echinococcus multilocularis cathepsin b 0.0422 0.3383 0.5023
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0169 0.0434
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0158 0.052
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0224 0.0297
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.1079 0.2114
Schistosoma mansoni hypothetical protein 0.0387 0.3095 0.6169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Mycobacterium tuberculosis Probable lipase LipE 0.019 0.1444 0.1421
Entamoeba histolytica hypothetical protein 0.003 0.011 0.0331
Loa Loa (eye worm) beta-lactamase 0.019 0.1444 0.2869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0509 0.1888
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.058 0.3902
Loa Loa (eye worm) hypothetical protein 0.0155 0.1154 0.2289
Echinococcus granulosus cathepsin l1 0.0078 0.0509 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Giardia lamblia Cathepsin B precursor 0.003 0.011 0.0331
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0509 0.1441
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0318 0.0799
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0052 0.0171
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0712 0.1028
Loa Loa (eye worm) nuclear factor I 0.0018 0.0009 0.0000056351
Brugia malayi MH2 domain containing protein 0.0033 0.0131 0.033
Onchocerca volvulus 0.0078 0.0509 0.1485
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0158 0.0425
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0249 0.0679
Loa Loa (eye worm) hypothetical protein 0.0478 0.3849 0.7675
Plasmodium vivax vivapain-2 0.0078 0.0509 0.3398
Trichomonas vaginalis esterase, putative 0.019 0.1444 0.5537
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1186 0.1737
Entamoeba histolytica cysteine protease, putative 0.003 0.011 0.0331
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0152 0.0495
Echinococcus granulosus bloom syndrome protein 0.0023 0.0047 0.0044
Echinococcus granulosus Smad4 0.0033 0.0131 0.0213
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Treponema pallidum NADH oxidase 0.0023 0.0052 0.0095
Loa Loa (eye worm) hypothetical protein 0.0078 0.051 0.1002
Plasmodium vivax unspecified product 0.003 0.011 0.0582
Brugia malayi cathepsin L precursor 0.003 0.011 0.0276
Loa Loa (eye worm) thioredoxin reductase 0.0067 0.0419 0.082
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0117 0.0184
Echinococcus granulosus acetylcholinesterase 0.0478 0.3849 0.7667
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.1045
Leishmania major cathepsin L-like protease 0.0078 0.0509 0.1478
Echinococcus granulosus beta LACTamase domain containing family member 0.019 0.1444 0.2846
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1444 0.5537
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.003 0.011 0.0331
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0055 0.0318 0.1143
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.003 0.011 0.0253
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0078 0.0509 0.8716
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0158 0.0267
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0212 0.0575
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0047 0.0033
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0052 0.0089
Schistosoma mansoni ran 0.0043 0.0212 0.041
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0117 0.0293
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0212 0.0533
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0152 0.0254
Brugia malayi hypothetical protein 0.005 0.0279 0.07
Echinococcus multilocularis beta LACTamase domain containing family member 0.019 0.1444 0.2123
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0052 0.0099
Schistosoma mansoni peroxidasin 0.0256 0.1994 0.3969
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0446 0.1305
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0248 0.0872
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.011 0.0582
Trypanosoma brucei prolyl oligopeptidase, putative 0.0171 0.1288 0.3886
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.034 0.0966
Loa Loa (eye worm) hypothetical protein 0.0055 0.0318 0.0618
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.011 0.0331
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.011 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0509 0.1499
Loa Loa (eye worm) hypothetical protein 0.019 0.1444 0.2869
Onchocerca volvulus 0.0256 0.1994 0.604
Toxoplasma gondii thioredoxin reductase 0.0067 0.0419 0.1209
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0099 0.0687 0.2043
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0027 0.001
Giardia lamblia Cathepsin L precursor 0.003 0.011 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0068 0.0168
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0117 0.0216
Echinococcus granulosus thioredoxin glutathione reductase 0.0067 0.0419 0.079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0212 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1122 0.4281
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0224 0.0399
Loa Loa (eye worm) hypothetical protein 0.019 0.1444 0.2869
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0117 0.0293
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0117 0.0282
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0052 0.0104
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.003 0.011 0.0582
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.003 0.011 0.0582
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.0821 0.1597
Toxoplasma gondii hypothetical protein 0.005 0.0274 0.0765
Brugia malayi RNA binding protein 0.007 0.0442 0.1111
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0052 0.0075
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0081 0.0531 0.0505
Brugia malayi hypothetical protein 0.013 0.0943 0.2367
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.015 0.0187
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0249 0.0872
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0025 0.0063
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1082 0.3252
Giardia lamblia Cathepsin B precursor 0.003 0.011 0.0331
Loa Loa (eye worm) hypothetical protein 0.0422 0.3383 0.6744
Brugia malayi cathepsin L-like cysteine proteinase 0.003 0.011 0.0276
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.2445 0.7204
Onchocerca volvulus 0.0078 0.0509 0.1485
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0386 0.2529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Plasmodium vivax importin-beta 2, putative 0.0058 0.034 0.2204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.011 0.0277
Brugia malayi hypothetical protein 0.0256 0.1994 0.5006
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.058 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0509 0.1888
Mycobacterium tuberculosis Probable hydrolase 0.019 0.1444 0.1421
Brugia malayi Animal haem peroxidase family protein 0.0256 0.1994 0.5006
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0152 0.0382
Plasmodium vivax vivapain-1 0.003 0.011 0.0582
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0117 0.0219
Onchocerca volvulus 0.0092 0.0626 0.1843
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0446 0.1253
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0052 0.0024
Brugia malayi MH1 domain containing protein 0.0033 0.0131 0.033
Loa Loa (eye worm) prolyl oligopeptidase 0.0213 0.1639 0.3258
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0509 0.0724
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.0821 0.1624
Brugia malayi beta-lactamase family protein 0.019 0.1444 0.3627
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0249 0.0666
Leishmania major trypanothione reductase 0.0067 0.0419 0.1203
Brugia malayi hypothetical protein 0.0303 0.2389 0.5999
Leishmania major hypothetical protein, conserved 0.0078 0.051 0.1482
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0081 0.0531 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0168 0.056
Giardia lamblia Cathepsin L precursor 0.003 0.011 0.0331
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0249 0.0448
Schistosoma mansoni inositol monophosphatase 0.0036 0.0158 0.0302
Brugia malayi cathepsin F-like cysteine proteinase 0.003 0.011 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0068 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0168 0.056
Mycobacterium ulcerans hypothetical protein 0.019 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.019 0.1444 0.2869
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.2588 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0052 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0158 0.0397
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0158 0.0397
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0509 0.1278
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0446 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.003 0.011 0.0331
Onchocerca volvulus Peroxidase homolog 0.0256 0.1994 0.604
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.0147 0.0119
Echinococcus granulosus expressed protein 0.0035 0.0147 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0068 0.0168
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.011 0.0276
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1964 0.7566
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0248 0.0872
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0027 0.0007
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0158 0.2366
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0374 0.2986 0.5937
Loa Loa (eye worm) hypothetical protein 0.0256 0.1994 0.3967

Activities

Activity type Activity value Assay description Source Reference
Log 1/D50 (functional) = 5.42 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 4.25 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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