TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 507.487 | Formula: C25H16F3N5O2S
H donors: 1 H acceptors: 2 LogP: 5.05 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1cccc(c1)C(F)(F)F)CSc1nc2ccccc2c2n1nc(c1ccccc1)c(=O)n2
InChi: 1S/C25H16F3N5O2S/c26-25(27,28)16-9-6-10-17(13-16)29-20(34)14-36-24-30-19-12-5-4-11-18(19)22-31-23(35)21(32-33(22)24)15-7-2-1-3-8-15/h1-13H,14H2,(H,29,34)
InChiKey: NYILFPZFBAZILB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0347	0.032
Trichomonas vaginalis	protein transport protein sec7, putative	0.0025	0.0174	0.0764
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.02	0.0306
Toxoplasma gondii	protein kinase domain-containing protein	0.0028	0.02	0.0865
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0028	0.02	0.2839
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0025	0.0174	0.0174
Brugia malayi	Syntrophin-1	0.0025	0.0174	0.0718
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0028	0.02	0.0881
Onchocerca volvulus		0.0035	0.0263	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Schistosoma mansoni	regulator of G protein signaling	0.0118	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0097	0.0054
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0028	0.02	0.2839
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0025	0.0174	0.0147
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0263	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0263	0.022
Schistosoma mansoni	axis inhibition protein axin	0.0118	0.0992	0.0992
Brugia malayi	PXA domain containing protein	0.0118	0.0992	0.5176
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0218	0.1876	0.184
Entamoeba histolytica	hypothetical protein	0.0118	0.0992	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0263	0.0263
Echinococcus granulosus	pleckstrin y domain containing family A	0.0025	0.0174	0.0147
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0263	0.0235
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Echinococcus granulosus	Regulator of G protein signaling 20	0.0118	0.0992	0.0967
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.02	0.0306
Onchocerca volvulus		0.0035	0.0263	0.0448
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0263	1
Echinococcus multilocularis	Pleckstrin y	0.0025	0.0174	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0097	0.007
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0028	0.02	0.2839
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Trypanosoma cruzi	NIMA-related kinase, putative	0.0028	0.02	0.2839
Brugia malayi	Dynamin	0.0025	0.0174	0.0718
Echinococcus granulosus	oxysterol binding protein 1	0.0025	0.0174	0.0147
Echinococcus multilocularis	myotubularin protein 13	0.0025	0.0174	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0992	0.0952
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Echinococcus granulosus	GRB2 associated binding protein 3	0.0025	0.0174	0.0147
Echinococcus granulosus	regulator of G protein signaling 3	0.0118	0.0992	0.0967
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0025	0.0174	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0118	0.0992	0.4602
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0992	0.0952
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0992	0.0952
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0347	0.0304
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0118	0.0992	0.0967
Brugia malayi	probable spectrin beta chain	0.0025	0.0174	0.0718
Trypanosoma cruzi	NIMA-related kinase, putative	0.0028	0.02	0.2839
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0263	0.1177
Entamoeba histolytica	hypothetical protein	0.0118	0.0992	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0266	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.0992	0.4602
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.0992	0.4602
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0233	0.0206
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0233	0.0233
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Echinococcus multilocularis	muscleblind protein 1	0.0166	0.1418	0.1394
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0097	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0263	0.022
Echinococcus multilocularis	oxysterol binding protein 9	0.0025	0.0174	0.0147
Schistosoma mansoni	regulator of G protein signaling	0.0118	0.0992	0.0992
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.02	0.02
Schistosoma mansoni	zinc finger protein	0.0025	0.0174	0.0174
Echinococcus granulosus	regulator of G protein signaling 7	0.0118	0.0992	0.0967
Echinococcus multilocularis	regulator of G protein signaling 7	0.0118	0.0992	0.0967
Loa Loa (eye worm)	syntrophin-1	0.0025	0.0174	0.0131
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0028	0.02	0.2839
Schistosoma mansoni	serine/threonine-protein kinase	0.0028	0.02	0.02
Echinococcus granulosus	axis inhibition protein axin	0.0118	0.0992	0.0967
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0411	0.201
Schistosoma mansoni	serine/threonine protein kinase	0.1137	1	1
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0025	0.0174	0.0147
Schistosoma mansoni	goodpasture antigen-binding protein	0.0025	0.0174	0.0174
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1137	1	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0025	0.0174	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0016
Entamoeba histolytica	protein kinase, putative	0.0028	0.02	0.0306
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Brugia malayi	Pre-SET motif family protein	0.0032	0.0233	0.1036
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0263	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0097	0.007
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0025	0.0174	0.0147
Schistosoma mansoni	syntrophin	0.0025	0.0174	0.0174
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0025	0.0174	0.0131
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0025	0.0174	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Schistosoma mansoni	cpg binding protein	0.0032	0.0232	0.0232
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Schistosoma mansoni	centaurin alpha	0.0025	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0233	0.019
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Plasmodium vivax	SET domain protein, putative	0.0032	0.0233	0.6623
Echinococcus multilocularis	muscleblind protein	0.0166	0.1418	0.1394
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0263	1
Echinococcus multilocularis	axis inhibition protein axin	0.0118	0.0992	0.0967
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0028	0.02	0.2839
Onchocerca volvulus		0.0035	0.0263	0.0448
Echinococcus multilocularis	beta 1 syntrophin	0.0025	0.0174	0.0147
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Schistosoma mansoni	cpg binding protein	0.003	0.0217	0.0217
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0464	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0118	0.0992	0.0952
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0025	0.0174	0.0147
Loa Loa (eye worm)	PH domain-containing protein	0.0025	0.0174	0.0131
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0347	0.032
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0992	0.0952
Entamoeba histolytica	protein kinase, putative	0.0028	0.02	0.0306
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0028	0.02	0.2839
Trypanosoma cruzi	Protein kinase B	0.0028	0.02	0.2839
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0263	0.1177
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.0992	0.4602
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0118	0.0992	0.0992
Echinococcus multilocularis	actin binding protein anillin	0.0025	0.0174	0.0147
Schistosoma mansoni	hypothetical protein	0.0427	0.3722	0.3722
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Entamoeba histolytica	protein kinase, putative	0.0028	0.02	0.0306
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.1937	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0347	0.032
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0523	0.0523
Brugia malayi	Protein kinase domain containing protein	0.0028	0.02	0.0854
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.012	0.1017	0.0977
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0025	0.0174	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Schistosoma mansoni	regulator of G protein signaling	0.0118	0.0992	0.0992
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0025	0.0174	0.0718
Loa Loa (eye worm)	oxysterol binding protein	0.0025	0.0174	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0263	0.022
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0263	0.022
Echinococcus multilocularis	Oxysterol binding protein 11	0.0025	0.0174	0.0147
Loa Loa (eye worm)	uncoordinated protein 104	0.0025	0.0174	0.0131
Echinococcus multilocularis	pdz domain containing protein	0.0025	0.0174	0.0147
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0028	0.02	0.2839
Echinococcus multilocularis	expressed protein	0.0118	0.0992	0.0967
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0028	0.02	0.0865
Leishmania major	protein kinase, putative	0.0028	0.02	0.2839
Echinococcus granulosus	regulator of G protein signaling 7	0.0118	0.0992	0.0967
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0263	1
Trichomonas vaginalis	alpha chimerin, putative	0.0025	0.0174	0.0764
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0.0174	0.0764
Entamoeba histolytica	protein kinase, putative	0.0028	0.02	0.0306
Brugia malayi	Dynamin	0.0025	0.0174	0.0718
Entamoeba histolytica	protein kinase, putative	0.0028	0.02	0.0306
Schistosoma mansoni	vav2	0.0025	0.0174	0.0174
Brugia malayi	A-kinase anchor protein 10, precursor	0.0118	0.0992	0.5176
Brugia malayi	hypothetical protein	0.0118	0.0992	0.5176
Brugia malayi	Cytohesin 3	0.0025	0.0174	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0992	0.0952
Schistosoma mansoni	hypothetical protein	0.0025	0.0174	0.0174
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.02	0.0306
Echinococcus multilocularis	cpg binding protein	0.0032	0.0232	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Schistosoma mansoni	dynamin	0.0025	0.0174	0.0174
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0025	0.0174	0.0147
Echinococcus multilocularis	axis inhibition protein axin	0.0118	0.0992	0.0967
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0028	0.02	0.2839
Echinococcus granulosus	muscleblind protein	0.0166	0.1418	0.1394
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0097	0.0297
Leishmania major	protein kinase, putative	0.0028	0.02	0.2839
Entamoeba histolytica	hypothetical protein	0.0118	0.0992	1
Echinococcus granulosus	Pleckstrin y	0.0025	0.0174	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1019	0.896	0.8957
Echinococcus multilocularis	dynamin 1	0.0025	0.0174	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Brugia malayi	PXA domain containing protein	0.0118	0.0992	0.5176
Trichomonas vaginalis	centaurin alpha, putative	0.0025	0.0174	0.0764
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0263	0.1177
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0118	0.0992	0.5176
Schistosoma mansoni	cpg binding protein	0.0032	0.0232	0.0232
Echinococcus granulosus	GPCR family 2	0.0016	0.0097	0.007
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.02	0.2839
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0025	0.0174	0.0147
Echinococcus granulosus	calcium dependent secretion activator 1	0.0025	0.0174	0.0147
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0347	0.0347
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0263	0.5
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0118	0.0992	0.0967
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0233	0.0233
Echinococcus granulosus	dnaJ subfamily B	0.0427	0.3722	0.3704
Entamoeba histolytica	p21-activated kinase	0.0028	0.02	0.0306
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0028	0.02	0.2839
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0028	0.02	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0025	0.0174	0.0174
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0263	0.5
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0025	0.0174	0.0147
Echinococcus granulosus	expressed protein	0.0118	0.0992	0.0967
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0025	0.0174	0.0174
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0233	0.0206
Brugia malayi	TBC domain containing protein	0.0025	0.0174	0.0718
Schistosoma mansoni	serine/threonine protein kinase	0.012	0.1017	0.1017
Echinococcus granulosus	dynamin 1	0.0025	0.0174	0.0147
Echinococcus multilocularis	regulator of G protein signaling 3	0.0118	0.0992	0.0967
Leishmania major	folate/biopterin transporter, putative	0.0028	0.02	0.2839
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0028	0.02	0.2839
Echinococcus multilocularis	rac serine:threonine kinase	0.0028	0.02	0.0172
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.2141	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0.0174	0.0764
Entamoeba histolytica	hypothetical protein	0.0028	0.02	0.0306
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Schistosoma mansoni	goodpasture antigen-binding protein	0.0025	0.0174	0.0174
Brugia malayi	Oxysterol binding protein	0.0025	0.0174	0.0718
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0025	0.0174	0.0764
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0266	0.1217
Echinococcus multilocularis	dnaJ subfamily B	0.0427	0.3722	0.3704
Brugia malayi	beta-lactamase	0.0035	0.0263	0.1199
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.02	0.0306
Echinococcus multilocularis	oxysterol binding protein 3	0.0025	0.0174	0.0147
Brugia malayi	Cadps2 protein	0.0025	0.0174	0.0718
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Echinococcus granulosus	pdz domain containing protein	0.0025	0.0174	0.0147
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0025	0.0174	0.0764
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0025	0.0174	0.0718
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.02	0.0306
Echinococcus granulosus	oxysterol binding protein 9	0.0025	0.0174	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0028	0.02	0.0156
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0028	0.02	0.2839
Brugia malayi	beta-lactamase family protein	0.0035	0.0263	0.1199
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.0992	0.4602
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0166	0.1418	0.138
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0028	0.02	0.2839
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0025	0.0174	0.0147
Entamoeba histolytica	hypothetical protein	0.0028	0.02	0.0306
Echinococcus multilocularis	regulator of G protein signaling	0.0118	0.0992	0.0967
Schistosoma mansoni	zinc finger protein	0.0025	0.0174	0.0174
Echinococcus granulosus	Pleckstrin y	0.0025	0.0174	0.0147
Trichomonas vaginalis	centaurin/arf, putative	0.0025	0.0174	0.0764
Brugia malayi	MAX-1A	0.0025	0.0174	0.0718
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0347	0.0347
Brugia malayi	regulator of G-protein signaling egl-10	0.0118	0.0992	0.5176
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.0992	0.4602
Schistosoma mansoni	z-protein (S1r protein)	0.0118	0.0992	0.0992
Schistosoma mansoni	hypothetical protein	0.0025	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Schistosoma mansoni	growth factor receptor-bound protein	0.0025	0.0174	0.0174
Trichomonas vaginalis	hypothetical protein	0.0025	0.0174	0.0764
Echinococcus multilocularis	Pleckstrin y	0.0025	0.0174	0.0147
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0025	0.0174	0.0147
Brugia malayi	Oxysterol-binding protein	0.0025	0.0174	0.0718
Leishmania major	serine/threonine-protein kinase a, putative	0.0028	0.02	0.2839
Entamoeba histolytica	protein kinase, putative	0.0028	0.02	0.0306
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0025	0.0174	0.0718
Echinococcus granulosus	Oxysterol binding protein 11	0.0025	0.0174	0.0147
Mycobacterium ulcerans	lipase LipD	0.0035	0.0263	0.5
Brugia malayi	hypothetical protein	0.0118	0.0992	0.5176
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0016
Echinococcus multilocularis	cytohesin 1	0.0025	0.0174	0.0147
Schistosoma mansoni	hypothetical protein	0.0025	0.0174	0.0174
Echinococcus granulosus	DCC interacting protein 13 beta	0.0025	0.0174	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Trichomonas vaginalis	esterase, putative	0.0035	0.0263	0.1177
Onchocerca volvulus		0.003	0.0217	0.0214
Trichomonas vaginalis	centaurin/arf, putative	0.0025	0.0174	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0266	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0411	0.0369
Brugia malayi	CXXC zinc finger family protein	0.003	0.0217	0.0948
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0025	0.0174	0.0147
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0263	0.1199
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0025	0.0174	0.0147
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0025	0.0174	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0347	0.0347
Echinococcus multilocularis	regulator of G protein signaling 3	0.0118	0.0992	0.0967
Echinococcus multilocularis	regulator of G protein signaling 7	0.0118	0.0992	0.0967
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0217	0.0173
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0028	0.02	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0992	0.0952
Echinococcus granulosus	beta 1 syntrophin	0.0025	0.0174	0.0147
Loa Loa (eye worm)	rho-GTPase-activating	0.0025	0.0174	0.0131
Entamoeba histolytica	protein kinase, putative	0.0028	0.02	0.0306
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0025	0.0174	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0263	0.022
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0025	0.0174	0.0147
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0025	0.0174	0.0131
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0411	0.201
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0028	0.02	0.2839
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Echinococcus multilocularis	Pleckstrin y	0.0025	0.0174	0.0147
Echinococcus granulosus	cpg binding protein	0.0032	0.0232	0.0204
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0118	0.0992	0.5176
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0028	0.02	0.2839
Brugia malayi	Muscleblind-like protein	0.0166	0.1418	0.7501
Trypanosoma brucei	protein kinase, putative	0.0028	0.02	0.2839
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0263	0.5
Echinococcus granulosus	Pleckstrin y	0.0025	0.0174	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Schistosoma mansoni	regulator of G protein signaling	0.0118	0.0992	0.0992
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0347	0.032
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0.0992	0.4602
Schistosoma mansoni	axis inhibition protein axin	0.0118	0.0992	0.0992
Leishmania major	hypothetical protein, conserved	0.0035	0.0263	1
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Brugia malayi	Uncoordinated protein 104	0.0025	0.0174	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0166	0.1418	0.138
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0263	0.1177
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0025	0.0174	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Brugia malayi	beta-lactamase family protein	0.0035	0.0263	0.1199
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1137	1	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0097
Brugia malayi	Pleckstrin Homology Domain	0.0025	0.0174	0.0718
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0097
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1019	0.896	0.8957
Echinococcus granulosus	myotubularin protein 13	0.0025	0.0174	0.0147
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.012	0.1017	0.5313
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0025	0.0174	0.0147
Trichomonas vaginalis	centaurin beta, putative	0.0025	0.0174	0.0764
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Schistosoma mansoni	dynamin	0.0025	0.0174	0.0174
Schistosoma mansoni	hypothetical protein	0.0025	0.0174	0.0174
Brugia malayi	Variant SH3 domain containing protein	0.0025	0.0174	0.0718
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0233	0.0233
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0028	0.02	0.2839
Schistosoma mansoni	rho gtpase activating protein	0.0025	0.0174	0.0174
Onchocerca volvulus		0.0248	0.2141	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0347	0.1657
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0263	1
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Brugia malayi	regulator of G-protein signaling rgs-7	0.0118	0.0992	0.5176
Schistosoma mansoni	regulator of G protein signaling	0.0118	0.0992	0.0992
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0118	0.0992	0.0992
Toxoplasma gondii	ABC1 family protein	0.0035	0.0263	0.3047
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0025	0.0174	0.0147
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0097
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0411	0.0369
Trichomonas vaginalis	protein transport protein sec7, putative	0.0025	0.0174	0.0764
Schistosoma mansoni	hypothetical protein	0.0025	0.0174	0.0174
Echinococcus granulosus	axis inhibition protein axin	0.0118	0.0992	0.0967
Echinococcus granulosus	serine/threonine protein kinase	0.0028	0.02	0.0172
Loa Loa (eye worm)	cytohesin 3	0.0025	0.0174	0.0131
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0233	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0233	0.2018
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0025	0.0174	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0263	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Onchocerca volvulus		0.0032	0.0233	0.0297
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0025	0.0174	0.00000014103
Brugia malayi	Pre-SET motif family protein	0.0218	0.1876	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0118	0.0992	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0263	0.022
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0028	0.02	0.2839
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0263	0.0235
Schistosoma mansoni	hypothetical protein	0.0016	0.0097	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0028	0.02	0.0881
Loa Loa (eye worm)	Plekhf2 protein	0.0025	0.0174	0.0131
Brugia malayi	Plekhf2 protein	0.0025	0.0174	0.0718
Echinococcus multilocularis	oxysterol binding protein 1	0.0025	0.0174	0.0147
Schistosoma mansoni	oxysterol-binding protein 1	0.0025	0.0174	0.0174
Brugia malayi	hypothetical protein	0.0025	0.0174	0.0718
Loa Loa (eye worm)	PXA domain-containing protein	0.0118	0.0992	0.0952
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0025	0.0174	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0118	0.0992	0.0967
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0097	0.0054
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0097	0.007
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0263	0.022
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0263	0.0263
Brugia malayi	PH domain containing protein	0.0025	0.0174	0.0718
Schistosoma mansoni	myotubularin-related protein	0.0025	0.0174	0.0174
Echinococcus granulosus	oxysterol binding protein 3	0.0025	0.0174	0.0147
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0118	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0263	0.022
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0097	0.007
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Trichomonas vaginalis	kinesin light chain, putative	0.0025	0.0174	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Brugia malayi	Variant SH3 domain containing protein	0.0025	0.0174	0.0718
Trichomonas vaginalis	AGC family protein kinase	0.0028	0.02	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0174	0.0131
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0025	0.0174	0.0147
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Echinococcus granulosus	cytohesin 1	0.0025	0.0174	0.0147
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0025	0.0174	0.0131
Loa Loa (eye worm)	RGS-3 protein	0.0118	0.0992	0.0952
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0217	0.019
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0028	0.0028
Schistosoma mansoni	oxysterol-binding protein 1	0.0025	0.0174	0.0174
Trichomonas vaginalis	centaurin gamma, putative	0.0025	0.0174	0.0764
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0174	0.0764
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0263	0.1177
Schistosoma mansoni	serine/threonine protein kinase	0.1137	1	1
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0025	0.0174	0.0764
Echinococcus granulosus	Rho GTPase activating protein 24	0.0025	0.0174	0.0147
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0097	0.007
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0025	0.0174	0.0174

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2299092

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1789928