Detailed information for compound 1791941

Basic information

Technical information
  • TDR Targets ID: 1791941
  • Name: (E)-3-(2,5-difluorophenyl)-N-[(1S)-1-(3-pyrid in-4-yloxyphenyl)ethyl]prop-2-enamide
  • MW: 380.387 | Formula: C22H18F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](c1cccc(c1)Oc1ccncc1)C)/C=C/c1cc(F)ccc1F
  • InChi: 1S/C22H18F2N2O2/c1-15(26-22(27)8-5-17-13-18(23)6-7-21(17)24)16-3-2-4-20(14-16)28-19-9-11-25-12-10-19/h2-15H,1H3,(H,26,27)/b8-5+/t15-/m0/s1
  • InChiKey: NVCQLCFDFSLHPE-PXTSUWAFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(2,5-difluorophenyl)-N-[(1S)-1-[3-(4-pyridyloxy)phenyl]ethyl]prop-2-enamide
  • (E)-3-(2,5-difluorophenyl)-N-[(1S)-1-[3-(4-pyridyloxy)phenyl]ethyl]acrylamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus potassium voltage-gated channel, subfamily Q, member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) voltage-gated potassium channel Get druggable targets OG5_129255 All targets in OG5_129255
Schistosoma japonicum ko:K05324 potassium voltage-gated channel, KQT-like subfamily, invertebrate, putative Get druggable targets OG5_129255 All targets in OG5_129255
Schistosoma mansoni voltage-gated potassium channel KCNQ Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129255 All targets in OG5_129255
Echinococcus granulosus potassium voltage gated channel subfamily KQT Get druggable targets OG5_129255 All targets in OG5_129255
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129255 All targets in OG5_129255
Schistosoma japonicum ko:K04927 potassium voltage-gated channel, KQT-like subfamily, member 2, putative Get druggable targets OG5_129255 All targets in OG5_129255
Echinococcus granulosus potassium channel KvQLT family member kqt 1 Get druggable targets OG5_129255 All targets in OG5_129255
Echinococcus multilocularis potassium voltage gated channel subfamily KQT Get druggable targets OG5_129255 All targets in OG5_129255
Echinococcus multilocularis potassium voltage gated channel subfamily KQT Get druggable targets OG5_129255 All targets in OG5_129255
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Echinococcus granulosus receptor type guanylyl cyclase 0.0033 0.0176 0.0209
Brugia malayi ORL1-like opioid receptor 0.0029 0.014 0.0327
Brugia malayi MH2 domain containing protein 0.0075 0.06 0.1425
Trypanosoma brucei glycerol uptake protein, putative 0.0018 0.003 0.0134
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0058 0.0434 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0112 0.0971 0.2309
Onchocerca volvulus 0.0029 0.014 0.0388
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0068 0.0528 0.0629
Schistosoma mansoni chromobox protein 0.0016 0.0013 0.0016
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.002 0.0049 0.0115
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0145 0.1294 1
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2125 0.5059
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1558 0.3708
Trichomonas vaginalis chromobox protein, putative 0.0016 0.0013 0.0026
Mycobacterium tuberculosis Probable hydrolase 0.0023 0.0077 0.0222
Mycobacterium tuberculosis Probable lipase LipE 0.0023 0.0077 0.0222
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0058 0.0434 0.0517
Trypanosoma brucei pyruvate kinase 1 0.0068 0.0527 0.2475
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0103 0.0122
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0272 0.1274
Echinococcus granulosus importin subunit beta 1 0.008 0.0652 0.0776
Brugia malayi hypothetical protein 0.0016 0.0013 0.0026
Entamoeba histolytica hypothetical protein 0.0131 0.1156 0.5433
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Loa Loa (eye worm) glutaminase 2 0.0435 0.4197 0.4996
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0393 0.3776 0.4497
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.003 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1258 0.1498
Brugia malayi Bromodomain containing protein 0.0029 0.0142 0.0333
Loa Loa (eye worm) MBOAT family protein 0.0018 0.003 0.0032
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0071 0.0556 0.0662
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1258 0.1498
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.014 0.0167
Plasmodium vivax SET domain protein, putative 0.0044 0.0292 0.3174
Onchocerca volvulus Heterochromatin protein 1 homolog 0.006 0.0449 0.1315
Leishmania major pyruvate kinase 0.0068 0.0527 0.2475
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2125 0.5059
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0068 0.0528 0.2482
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0045 0.0305 0.0363
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.014 0.0167
Onchocerca volvulus 0.0023 0.0077 0.02
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0106 0.0913 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.014 0.0167
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0103 0.0103
Echinococcus granulosus pyruvate kinase 0.0035 0.0198 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.0112 0.0971 0.2309
Giardia lamblia Kinase, PLK 0.0228 0.2125 1
Echinococcus granulosus chromobox protein 1 0.0099 0.0842 0.1003
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0176 0.0206
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0077 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.014 0.0164
Echinococcus multilocularis lysosomal alpha glucosidase 0.0144 0.1289 0.1289
Toxoplasma gondii dgat2l1-prov protein 0.0068 0.0528 0.5782
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0161 0.0188
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0077 0.0178
Echinococcus multilocularis translational activator gcn1 0.0015 0.0003 0.0003
Trypanosoma brucei glucosidase, putative 0.0032 0.017 0.0796
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.014 0.014
Echinococcus multilocularis snurportin 1 0.0856 0.8397 0.8397
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.014 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.014 0.0167
Schistosoma mansoni tyrosine kinase 0.0033 0.0176 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2125 0.5059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Loa Loa (eye worm) MBOAT family protein 0.0018 0.003 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Brugia malayi Pre-SET motif family protein 0.0307 0.2921 0.6957
Mycobacterium tuberculosis Probable lipase LipD 0.0023 0.0077 0.0222
Loa Loa (eye worm) TAR-binding protein 0.0054 0.0388 0.0459
Trichomonas vaginalis glucosylceramidase, putative 0.0112 0.0971 0.2309
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0018 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0026
Brugia malayi Bromodomain containing protein 0.0057 0.0421 0.0997
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0077 0.0357
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0016 0.0013 0.0016
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0272 0.0321
Schistosoma mansoni glutamate receptor NMDA 0.0033 0.0176 0.0209
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0015 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0089 0.0736 0.0874
Schistosoma mansoni protein kinase 0.0033 0.0176 0.0209
Schistosoma mansoni hypothetical protein 0.0015 0.0001 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0061 0.0462 0.055
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.014 0.014
Entamoeba histolytica hypothetical protein 0.0065 0.05 0.2346
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Leishmania major glycerol uptake protein, putative 0.0018 0.003 0.0134
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0103 0.0103
Schistosoma mansoni chromobox protein 0.0099 0.0842 0.1003
Onchocerca volvulus 0.0016 0.0013 0.0009
Brugia malayi putative neuropeptide receptor 0.0029 0.014 0.0327
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0527 0.0624
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0388 0.0462
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0103 0.0122
Trichomonas vaginalis chromobox protein, putative 0.006 0.0449 0.1064
Echinococcus multilocularis lamin dm0 0.0016 0.0011 0.0011
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0056 0.0412 0.0975
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0103 0.0122
Echinococcus granulosus g-protein coupled receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) glutaminase 0.0435 0.4197 0.4996
Trichomonas vaginalis importin beta-1, putative 0.0065 0.05 0.1187
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.002 0.0049 0.0514
Brugia malayi Intermediate filament tail domain containing protein 0.0016 0.0011 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0023 0.0077 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.03 0.2849 0.3392
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.014 0.014
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.014 0.014
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0254 0.0303
Mycobacterium tuberculosis Conserved protein 0.0023 0.0077 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0103 0.0238
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0103 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.014 0.0167
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.001
Brugia malayi Dopamine receptor protein 1 0.0029 0.014 0.0327
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.014 0.0167
Entamoeba histolytica vacuolar protein sorting 26 0.0018 0.003 0.0127
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.014 0.0167
Trypanosoma cruzi glycerol uptake protein, putative 0.0018 0.003 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Leishmania major diacylglycerol acyltransferase, putative 0.0068 0.0528 0.2482
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.014 0.0167
Echinococcus granulosus neuropeptide receptor 0.0029 0.014 0.0167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0061 0.0462 0.0462
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0322 0.0381
Echinococcus granulosus transportin 1 0.0015 0.0003 0.0003
Brugia malayi CHD4 protein 0.0018 0.0028 0.006
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0017 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0206
Schistosoma mansoni adenoreceptor 0.0029 0.014 0.0167
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0017 0.0023 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.017 0.04
Brugia malayi MBOAT family protein 0.0018 0.003 0.0064
Echinococcus granulosus glutamate receptor 2 0.0033 0.0176 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0077 0.0178
Echinococcus granulosus somatostatin receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0388 0.0462
Loa Loa (eye worm) RNA binding protein 0.0054 0.0388 0.0459
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0176 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0103 0.0238
Trichomonas vaginalis esterase, putative 0.0023 0.0077 0.0178
Brugia malayi latrophilin 2 splice variant baaae 0.0132 0.1171 0.2786
Trichomonas vaginalis glucosylceramidase, putative 0.0112 0.0971 0.2309
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0131 0.1156 0.1376
Schistosoma mansoni hypothetical protein 0.0106 0.0914 0.1089
Leishmania major hypothetical protein, conserved 0.0017 0.0018 0.0078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0065 0.05 0.1187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Schistosoma mansoni opsin-like receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Schistosoma mansoni metabotropic glutamate receptor 0.029 0.2743 0.3266
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.014 0.014
Echinococcus multilocularis pyruvate kinase 0.0035 0.0198 0.0198
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0008 0.0006
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0228 0.2125 0.2528
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.014 0.014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0026
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.017 0.04
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0018 0.0078
Echinococcus multilocularis fmrfamide receptor 0.0029 0.014 0.014
Onchocerca volvulus 0.0025 0.0103 0.0276
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0176 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Mycobacterium tuberculosis Conserved protein 0.0023 0.0077 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Brugia malayi PHD-finger family protein 0.0019 0.0041 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0171 0.1558 0.3708
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.017 0.0203
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0421 0.0421
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0054 0.0388 0.0459
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.014 0.014
Echinococcus multilocularis lysosomal alpha glucosidase 0.0144 0.1289 0.1289
Brugia malayi sulfakinin receptor protein 0.0029 0.014 0.0327
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0176 0.0209
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.014 0.0167
Onchocerca volvulus Serine\/threonine kinase homolog 0.0228 0.2125 0.6341
Echinococcus granulosus snurportin 1 0.0856 0.8397 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0018 0.003 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0077 0.0818
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0016 0.0013 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.014 0.0167
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.014 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.014 0.0167
Brugia malayi Pre-SET motif family protein 0.0044 0.0292 0.0689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0124 0.0124
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0176 0.0206
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0068 0.0527 0.3834
Echinococcus multilocularis GPCR, family 2 0.0061 0.0462 0.0462
Echinococcus granulosus metabotropic glutamate receptor 5 0.0426 0.41 0.4883
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0061 0.0462 0.1096
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0056 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0112 0.0971 0.2309
Trichomonas vaginalis set domain proteins, putative 0.035 0.3345 0.7968
Loa Loa (eye worm) hypothetical protein 0.0056 0.0412 0.0487
Brugia malayi G-protein coupled receptor 0.0029 0.014 0.0327
Loa Loa (eye worm) hypothetical protein 0.0426 0.41 0.4881
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0077 0.0357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0103 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2125 0.5059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0421 0.0501
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0013 0.0016
Brugia malayi diacylglycerol acyltransferase 0.0106 0.0913 0.217
Trichomonas vaginalis Heterochromatin protein, putative 0.0016 0.0013 0.0026
Toxoplasma gondii LsmAD domain-containing protein 0.0017 0.0018 0.0182
Onchocerca volvulus 0.0029 0.014 0.0388
Schistosoma mansoni hypothetical protein 0.0018 0.003 0.0035
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.1031 0.2452
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.024 0.024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0044 0.0292 0.3185
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.014 0.0167
Schistosoma mansoni coup transcription factor 0.0025 0.0103 0.0122
Brugia malayi Receptor family ligand binding region containing protein 0.0033 0.0176 0.0413
Echinococcus granulosus atrial natriuretic peptide receptor 0.0033 0.0176 0.0209
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0103 0.0122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0089
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0426 0.41 0.41
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0077 0.0357
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus multilocularis pyruvate kinase 0.0068 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Echinococcus granulosus g protein coupled receptor 0.0029 0.014 0.0167
Brugia malayi Dopamine receptor 0.0029 0.014 0.0327
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0322 0.1506
Echinococcus multilocularis tar DNA binding protein 0.0054 0.0388 0.0388
Schistosoma mansoni metabotropic glutamate receptor 0.0168 0.1534 0.1826
Echinococcus multilocularis sterol O acyltransferase 1 0.0018 0.003 0.003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0103 0.0119
Trichomonas vaginalis chromobox protein, putative 0.0016 0.0013 0.0026
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.03 0.2849 0.3392
Toxoplasma gondii HEAT repeat-containing protein 0.008 0.0652 0.7137
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.014 0.014
Schistosoma mansoni biogenic amine receptor 0.0029 0.014 0.0167
Brugia malayi AKH receptor 0.0029 0.014 0.0327
Loa Loa (eye worm) hhat protein 0.0018 0.003 0.0032
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.017 0.079
Trypanosoma cruzi GUP1, putative 0.0018 0.003 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0103 0.0119
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0228 0.2125 1
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0077 0.0178
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0023 0.0077 0.0181
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0033 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0056 0.0407 0.0481
Onchocerca volvulus 0.0016 0.0013 0.0009
Echinococcus granulosus metabotropic glutamate receptor 2 0.029 0.2743 0.3266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0103 0.0238
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Brugia malayi Serotonin receptor 0.0029 0.014 0.0327
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.014 0.0164
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.014 0.014
Onchocerca volvulus 0.0023 0.0077 0.02
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0061 0.0462 0.055
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0089 0.0736 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0103 0.0238
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0018 0.003 0.0035
Leishmania major phosphopantetheinyl transferase-like protein 0.002 0.0049 0.0227
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Mycobacterium ulcerans pyruvate kinase 0.0068 0.0527 0.1252
Echinococcus granulosus pyruvate kinase 0.0035 0.0198 0.0236
Brugia malayi diacylglycerol acyltransferase family protein 0.0068 0.0528 0.1253
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0206
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0078 0.0631 0.0752
Brugia malayi M-phase phosphoprotein, mpp8 0.0016 0.0013 0.0026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.014 0.014
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.014 0.0388
Schistosoma mansoni hypothetical protein 0.0132 0.1171 0.1395
Echinococcus multilocularis chromobox protein 1 0.0099 0.0842 0.0842
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0015 0.0001 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0103 0.0122
Trichomonas vaginalis transmembrane protein nessy, putative 0.0018 0.003 0.0064
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0061 0.0462 0.0462
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0856 0.8397 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.001 0.0042
Echinococcus multilocularis orexin receptor type 2 0.0029 0.014 0.014
Echinococcus granulosus microtubule associated protein 2 0.061 0.5942 0.7076
Leishmania major glycerol uptake protein, putative 0.0018 0.003 0.0134
Trypanosoma cruzi glycerol uptake protein, putative 0.0018 0.003 0.0134
Brugia malayi hypothetical protein 0.0017 0.0018 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.014 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Echinococcus granulosus serotonin receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2125 0.5059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0103 0.0238
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.014 0.0167
Brugia malayi beta-lactamase family protein 0.0023 0.0077 0.0178
Onchocerca volvulus 0.0029 0.014 0.0388
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.014 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.014 0.0167
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0174 0.1585 0.1585
Echinococcus granulosus geminin 0.0106 0.0914 0.1089
Echinococcus multilocularis pyruvate kinase 0.0035 0.0198 0.0198
Brugia malayi hypothetical protein 0.0033 0.0176 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0292 0.0347
Schistosoma mansoni alpha-glucosidase 0.0124 0.1089 0.1297
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0033 0.0176 0.0496
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0033 0.0176 0.0206
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0174 0.1585 0.1888
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0124 0.0148
Schistosoma mansoni amine GPCR 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0071 0.0556 0.0659
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.03 0.2849 0.6785
Schistosoma mansoni amine GPCR 0.0029 0.014 0.0167
Loa Loa (eye worm) voltage-gated potassium channel 0.0171 0.1556 0.185
Echinococcus granulosus intermediate filament protein 0.0016 0.0011 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0112 0.0971 0.2309
Echinococcus multilocularis pyruvate kinase 0.0053 0.0384 0.0384
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0313 0.2978 0.7095
Echinococcus granulosus tyrosine kinase 0.0033 0.0176 0.0209
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Echinococcus multilocularis nmda type glutamate receptor 0.0033 0.0176 0.0176
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.014 0.0167
Brugia malayi MBOAT family protein 0.0018 0.003 0.0064
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.014 0.0167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0023 0.0077 0.0222
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0013 0.0118
Brugia malayi G-protein coupled receptor 0.0029 0.014 0.0327
Brugia malayi larval opioid receptor 0.0029 0.014 0.0327
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0272 0.2957
Echinococcus granulosus orexin receptor type 2 0.0029 0.014 0.0167
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.017 0.04
Schistosoma mansoni hypothetical protein 0.0061 0.0462 0.055
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0103 0.0122
Leishmania major glycerol uptake protein, putative 0.0018 0.003 0.0134
Echinococcus multilocularis receptor type guanylyl cyclase 0.0033 0.0176 0.0176
Echinococcus multilocularis neuropeptide receptor 0.0029 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0029 0.014 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1258 0.1258
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.014 0.0164
Schistosoma mansoni microtubule-associated protein tau 0.061 0.5942 0.7076
Echinococcus granulosus GPCR family 3 C terminal 0.0056 0.0412 0.049
Entamoeba histolytica hypothetical protein 0.0018 0.003 0.0127
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.014 0.0327
Echinococcus multilocularis chromobox protein 2 0.0016 0.0013 0.0013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0103 0.0103
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0103 0.0122
Brugia malayi beta-lactamase 0.0023 0.0077 0.0178
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0015 0.0001 0.0002
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.002 0.0049 0.5
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0103 0.0238
Entamoeba histolytica hypothetical protein 0.0016 0.0013 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.002 0.0049 0.0529
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0018 0.0166
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0091 0.0758 0.09
Brugia malayi glutaminase DH11.1 0.0435 0.4197 1
Plasmodium vivax ataxin-2 like protein, putative 0.0017 0.0018 0.0166
Onchocerca volvulus 0.0029 0.014 0.0388
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.06 0.0712
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.014 0.0167
Schistosoma mansoni opsin-like receptor 0.0029 0.014 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1558 0.3708
Echinococcus granulosus o acyltransferase membrane bound domain 0.0018 0.003 0.0035
Brugia malayi Receptor family ligand binding region containing protein 0.0089 0.0736 0.1749
Brugia malayi Calcitonin receptor-like protein seb-1 0.0193 0.1782 0.4242
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0018 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Brugia malayi Importin beta-1 subunit 0.008 0.0652 0.1548
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0254 0.0303
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.014 0.0327
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0018 0.003 0.0127
Onchocerca volvulus 0.0033 0.0176 0.0496
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0031 0.0159 0.1729
Schistosoma mansoni hypothetical protein 0.0029 0.014 0.0167
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Onchocerca volvulus 0.0029 0.014 0.0388
Schistosoma mansoni tyrosine kinase 0.0033 0.0176 0.0209
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0071 0.0556 0.1319
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0033 0.0176 0.0209
Mycobacterium ulcerans glutaminase 0.0435 0.4197 1
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0388 0.0462
Trypanosoma brucei glycerol uptake protein, putative 0.0018 0.003 0.0134
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0176 0.0209
Brugia malayi Glycosyl hydrolases family 31 protein 0.0144 0.1289 0.3068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0023 0.0077 0.0089
Trypanosoma brucei PAB1-binding protein , putative 0.0017 0.0018 0.0078
Echinococcus granulosus lysosomal alpha glucosidase 0.0144 0.1289 0.1535
Trichomonas vaginalis ran, putative 0.0042 0.0272 0.0642
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0018 0.003 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1258 0.1498
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0307 0.2921 0.3476
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0103 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2125 0.5059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1258 0.2993
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0103 0.0238
Schistosoma mansoni hypothetical protein 0.0106 0.0914 0.1089
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0527 0.2475
Echinococcus multilocularis tyrosine kinase 0.0033 0.0176 0.0176
Brugia malayi jmjC domain containing protein 0.0039 0.024 0.0566
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0016 0.0013 0.0016
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0106 0.0913 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0421 0.0501
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0023 0.0077 0.0222
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0272 0.1274
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0103 0.0238
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1258 0.1495
Loa Loa (eye worm) hypothetical protein 0.0088 0.0734 0.0872
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Trypanosoma brucei pyruvate kinase 1, putative 0.0068 0.0527 0.2475
Brugia malayi steroid hormone receptor 0.0025 0.0103 0.0238
Chlamydia trachomatis pyruvate kinase 0.0068 0.0527 1
Schistosoma mansoni biogenic amine receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.008 0.0652 0.0773
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0042 0.0275 0.0328
Echinococcus multilocularis transportin 1 0.0015 0.0003 0.0003
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0068 0.0528 0.0626
Loa Loa (eye worm) helicase 0.0016 0.0013 0.0013
Schistosoma mansoni importin-beta 2 0.0015 0.0003 0.0003
Echinococcus granulosus GPCR family 2 0.0061 0.0462 0.055
Loa Loa (eye worm) latrophilin receptor protein 2 0.0061 0.0462 0.0547
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0006
Schistosoma mansoni amine GPCR 0.0029 0.014 0.0167
Schistosoma mansoni jumonji domain containing protein 0.0039 0.024 0.0286
Echinococcus granulosus importin 5 0.0015 0.0003 0.0003
Onchocerca volvulus Glucosylceramidase homolog 0.0112 0.0971 0.288
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0103 0.0103
Loa Loa (eye worm) beta-lactamase 0.0023 0.0077 0.0089
Trichomonas vaginalis chromobox protein, putative 0.0099 0.0842 0.2001
Schistosoma mansoni chromobox protein 0.0016 0.0013 0.0016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.014 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0023 0.0077 0.0178
Leishmania major GTP-binding protein, putative 0.0042 0.0272 0.1274
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0103 0.0122
Onchocerca volvulus 0.0071 0.0556 0.1636
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1258 0.1498
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0103 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0977 0.2322
Schistosoma mansoni amine GPCR 0.0029 0.014 0.0167
Onchocerca volvulus Poor gastrulation protein homolog 0.0056 0.0412 0.1202
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.014 0.0167
Brugia malayi Serotonin receptor 0.0029 0.014 0.0327
Brugia malayi MBOAT family protein 0.0018 0.003 0.0064
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0018 0.003 0.0127
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0527 0.1249
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0077 0.058
Echinococcus granulosus beta LACTamase domain containing family member 0.0023 0.0077 0.0092
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0186
Schistosoma mansoni hypothetical protein 0.0029 0.014 0.0167
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.014 0.0327
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Schistosoma mansoni hypothetical protein 0.0061 0.0462 0.055
Echinococcus granulosus fetal alzheimer antigen falz 0.0017 0.0023 0.0027
Brugia malayi SET domain containing protein 0.0018 0.003 0.0064
Entamoeba histolytica hypothetical protein 0.0016 0.0013 0.0051
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.014 0.0164
Schistosoma mansoni lamin 0.0016 0.0011 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0103 0.0122
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0058 0.0434 0.2038
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0091 0.0758 0.0903
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1558 0.3708
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0018 0.003 0.0035
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.014 0.0164
Echinococcus granulosus L aminoadipate semialdehyde 0.0071 0.0556 0.0662
Brugia malayi Metabotropic glutamate receptor precursor. 0.0346 0.3303 0.7868
Echinococcus granulosus nmda type glutamate receptor 0.0033 0.0176 0.0209
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Schistosoma mansoni pyruvate kinase 0.0068 0.0527 0.0627
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0527 0.1548
Onchocerca volvulus 0.006 0.0454 0.1329
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.014 0.0167
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0198 0.2146
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0058 0.0434 0.2038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0103 0.0103
Brugia malayi hypothetical protein 0.0131 0.1156 0.2749
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Mycobacterium tuberculosis Conserved protein 0.0023 0.0077 0.0222
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.014 0.0167
Mycobacterium tuberculosis Probable esterase LipL 0.0023 0.0077 0.0222
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0068 0.0528 0.2482
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Brugia malayi Pyruvate kinase, muscle isozyme 0.0068 0.0527 0.1249
Entamoeba histolytica hypothetical protein 0.0131 0.1156 0.5433
Echinococcus multilocularis serotonin receptor 0.0029 0.014 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.017 0.04
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Schistosoma mansoni alpha glucosidase 0.0032 0.017 0.0203
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0016 0.0013 0.0016
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Brugia malayi Associated with TFs and helicases family protein 0.0016 0.0013 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0245 0.0577
Trypanosoma cruzi GUP1, putative 0.0018 0.003 0.0134
Brugia malayi G protein-coupled receptor 0.0029 0.014 0.0327
Toxoplasma gondii pyruvate kinase PyK1 0.0068 0.0527 0.5764
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0527 0.0624
Onchocerca volvulus 0.0029 0.014 0.0388
Brugia malayi follicle stimulating hormone receptor 0.0029 0.014 0.0327
Loa Loa (eye worm) glutamate receptor 0.0346 0.3303 0.3931
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Onchocerca volvulus 0.0018 0.003 0.0057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0206
Entamoeba histolytica hypothetical protein 0.0033 0.0176 0.0816
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0106 0.0913 0.1084
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.017 0.04
Plasmodium falciparum pyruvate kinase 0.0068 0.0527 0.5758
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0018 0.003 0.0127
Onchocerca volvulus 0.0029 0.014 0.0388
Brugia malayi Heterochromatin protein 1 0.0099 0.0842 0.2001
Echinococcus multilocularis Chromo domain 0.0016 0.0013 0.0013
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0228 0.2125 0.2125
Plasmodium falciparum importin beta, putative 0.008 0.0652 0.7133
Trypanosoma cruzi importin beta-1 subunit, putative 0.0065 0.05 0.2351
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.014 0.014
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0527 0.1249
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.014 0.014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0103 0.0119
Schistosoma mansoni biogenic amine receptor 0.0029 0.014 0.0167
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.017 0.017
Leishmania major hypothetical protein, conserved 0.0018 0.003 0.0134
Schistosoma mansoni kinase 0.0116 0.1007 0.1199
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Schistosoma mansoni hypothetical protein 0.0056 0.0412 0.049
Loa Loa (eye worm) heterochromatin protein 1 0.0099 0.0842 0.1
Brugia malayi beta-lactamase family protein 0.0023 0.0077 0.0178
Echinococcus multilocularis sex peptide receptor 0.0029 0.014 0.014
Leishmania major pyruvate kinase 0.0068 0.0527 0.2475
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0454 0.054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0103 0.0122
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Schistosoma mansoni chromobox protein 0.0099 0.0842 0.1003
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0421 0.0501
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0206
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Onchocerca volvulus 0.0029 0.014 0.0388
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.014 0.0164
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0018 0.003 0.0035
Toxoplasma gondii ABC1 family protein 0.0023 0.0077 0.0832
Brugia malayi MBOAT family protein 0.0018 0.003 0.0064
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.0028 0.0028
Schistosoma mansoni bromodomain containing protein 0.0048 0.0332 0.0395
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0977 0.2322
Onchocerca volvulus 0.0029 0.014 0.0388
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0527 0.1548
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.014 0.0327
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0254 0.03
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.014 0.0167
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0018 0.003 0.003
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0056 0.0412 0.1202
Schistosoma mansoni zinc finger protein 0.0018 0.003 0.0035
Trypanosoma cruzi polo-like protein kinase, putative 0.0228 0.2125 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0103 0.0238
Echinococcus multilocularis transcription factor Dp 1 0.0034 0.0189 0.0189
Loa Loa (eye worm) glutamate receptor 0.0136 0.1209 0.1437
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.014 0.0167
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.014 0.0167
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Schistosoma mansoni ran 0.0042 0.0272 0.0324
Echinococcus granulosus chromobox protein 1 0.0099 0.0842 0.1003
Toxoplasma gondii HEAT repeat-containing protein 0.0015 0.0003 0.0016
Plasmodium falciparum heterochromatin protein 1 0.0016 0.0013 0.0118
Entamoeba histolytica hypothetical protein 0.0131 0.1156 0.5433
Loa Loa (eye worm) intermediate filament protein 0.0016 0.0011 0.0009
Echinococcus multilocularis fmrfamide receptor 0.0029 0.014 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Brugia malayi RE15519p 0.0029 0.014 0.0327
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Entamoeba histolytica hypothetical protein 0.002 0.0049 0.022
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus granulosus fmrfamide receptor 0.0029 0.014 0.0167
Leishmania major hypothetical protein, conserved 0.0015 0.0003 0.0007
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0033 0.0176 0.0176
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0065 0.05 0.1187
Brugia malayi jmjC domain containing protein 0.004 0.0254 0.06
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0089
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.017 0.1855
Loa Loa (eye worm) hhat protein 0.0018 0.003 0.0032
Schistosoma mansoni neuropeptide receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0132 0.1171 0.1392
Brugia malayi TAR-binding protein 0.0054 0.0388 0.0919
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0228 0.2125 0.253
Trypanosoma cruzi polo-like protein kinase, putative 0.0228 0.2125 1
Brugia malayi RNA binding protein 0.0054 0.0388 0.0919
Brugia malayi Latrophilin receptor protein 2 0.0061 0.0462 0.1096
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0272 0.0272
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0388 0.0462
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0103 0.0122
Echinococcus granulosus g protein coupled receptor 0.0029 0.014 0.0167
Trypanosoma brucei polo-like protein kinase 0.0228 0.2125 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0527 0.2475
Schistosoma mansoni hypothetical protein 0.0856 0.8397 1
Toxoplasma gondii HEAT repeat-containing protein 0.0015 0.0003 0.0016
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0174 0.1585 0.1888
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0018 0.003 0.0035
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Onchocerca volvulus 0.0083 0.0683 0.2017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0103 0.0238
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0023 0.0077 0.0178
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1558 0.3708
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.002 0.0049 0.0514
Schistosoma mansoni glutaminase 0.0435 0.4197 0.4998
Loa Loa (eye worm) hypothetical protein 0.0029 0.0143 0.0167
Schistosoma mansoni pyruvate kinase 0.0035 0.0198 0.0236
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0018 0.0166
Trypanosoma cruzi extracellular receptor, putative 0.0033 0.0176 0.0822
Giardia lamblia Pyruvate kinase 0.0068 0.0527 0.1706
Schistosoma mansoni transcription factor LCR-F1 0.0131 0.1156 0.1376
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0103 0.0238
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.014 0.0164
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0089
Echinococcus multilocularis pyruvate kinase 0.0035 0.0198 0.0198
Brugia malayi Glycosylation related protein 12, isoform 0.0031 0.0159 0.0372
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Toxoplasma gondii hypothetical protein 0.0018 0.003 0.0312
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Onchocerca volvulus 0.0044 0.0287 0.0828
Brugia malayi metabotropic glutamate receptor type 2 0.0168 0.1534 0.365
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0026
Brugia malayi Pyruvate kinase, M2 isozyme 0.0068 0.0527 0.1249
Loa Loa (eye worm) hypothetical protein 0.0068 0.0527 0.0624
Echinococcus granulosus hypothetical protein 0.0029 0.014 0.0167
Echinococcus granulosus chromobox protein 2 0.0016 0.0013 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0103 0.0276
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0018 0.003 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0103 0.0119
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0176 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Echinococcus multilocularis microtubule associated protein 2 0.061 0.5942 0.5942
Echinococcus multilocularis g protein coupled receptor 0.0029 0.014 0.014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.014 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0245 0.0577
Trypanosoma cruzi glycerol uptake protein, putative 0.0018 0.003 0.0134
Echinococcus granulosus sex peptide receptor 0.0029 0.014 0.0167
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.014 0.0167
Entamoeba histolytica hypothetical protein 0.0131 0.1156 0.5433
Schistosoma mansoni hypothetical protein 0.0061 0.0462 0.055
Trichomonas vaginalis penicillin-binding protein, putative 0.0023 0.0077 0.0178
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.014 0.0327
Echinococcus multilocularis g protein coupled receptor 0.0029 0.014 0.014
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0322 0.0381
Echinococcus multilocularis L aminoadipate semialdehyde 0.0071 0.0556 0.0556
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0103 0.0238
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.014 0.0167
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.014 0.0167
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0106 0.0913 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.014 0.0167
Brugia malayi nuclear hormone receptor 0.0025 0.0103 0.0238
Mycobacterium ulcerans esterase/lipase LipP 0.0023 0.0077 0.0181
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0176 0.0209
Onchocerca volvulus 0.0068 0.0528 0.1553
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0103 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0193 0.1782 0.212
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0174 0.1585 0.3773
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Trichomonas vaginalis porcupine, putative 0.0018 0.003 0.0064
Treponema pallidum 4'-phosphopantetheinyl transferase 0.002 0.0049 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0272 0.0324
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.014 0.0167
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0091 0.0758 0.0903
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.1031 0.2452
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0103 0.0238
Echinococcus multilocularis Chromobox protein 3 0.0016 0.0013 0.0013
Echinococcus multilocularis chromobox protein 1 0.0099 0.0842 0.0842
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.014 0.0167
Schistosoma mansoni neuropeptide receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0078 0.0631 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0103 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1558 0.3708
Echinococcus granulosus sterol O acyltransferase 1 0.0018 0.003 0.0035
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.014 0.014
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0103 0.0276
Brugia malayi neuropeptide F receptor 0.0029 0.014 0.0327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0103 0.0103
Echinococcus multilocularis importin 5 0.0015 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1258 0.1258
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.014 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Trypanosoma brucei importin beta-1 subunit, putative 0.008 0.0652 0.3064
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Mycobacterium ulcerans beta-lactamase 0.0023 0.0077 0.0181
Loa Loa (eye worm) hypothetical protein 0.0057 0.0421 0.0498
Trichomonas vaginalis chromobox protein, putative 0.0016 0.0013 0.0026
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.03 0.2849 0.2849
Leishmania major hypothetical protein, conserved 0.0023 0.0077 0.0357
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0089
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0103 0.0122
Loa Loa (eye worm) hypothetical protein 0.0054 0.0389 0.046
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0058 0.0434 0.2038
Echinococcus granulosus o acyltransferase membrane bound domain 0.0018 0.003 0.0035
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0091 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.014 0.0167
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0171 0.1558 0.1852
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.003 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Echinococcus multilocularis GPCR, family 3, C terminal 0.0056 0.0412 0.0412
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0023 0.0077 0.0092
Echinococcus multilocularis importin subunit beta 1 0.008 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0193 0.1782 0.212
Brugia malayi RNA, U transporter 1 0.0228 0.2128 0.5067
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0272 0.0383
Loa Loa (eye worm) hypothetical protein 0.0091 0.0758 0.09
Echinococcus granulosus neuropeptide s receptor 0.0029 0.014 0.0167
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0016 0.0013 0.0118
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0028 0.003
Schistosoma mansoni neuropeptide receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.017 0.02
Plasmodium vivax heterochromatin protein 1, putative 0.0016 0.0013 0.0118
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0056 0.0407 0.1188
Echinococcus granulosus lamin 0.0016 0.0011 0.0013
Trichomonas vaginalis hypothetical protein 0.0016 0.0013 0.0026
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0103 0.0122
Leishmania major importin beta-1 subunit, putative 0.0065 0.05 0.2351
Onchocerca volvulus 0.0029 0.014 0.0388
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1558 0.3708
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0206
Brugia malayi hypothetical protein 0.0029 0.014 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0388 0.0462
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0028 0.0033
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.014 0.0164
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.014 0.0167
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0089 0.0736 0.0874
Brugia malayi Hhat protein 0.0018 0.003 0.0064
Brugia malayi neuropeptide F receptor 0.0029 0.014 0.0327
Echinococcus granulosus o acyltransferase membrane bound domain 0.0018 0.003 0.0035
Trichomonas vaginalis glutaminase, putative 0.0435 0.4197 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0119
Schistosoma mansoni histamine h1 receptor 0.0029 0.014 0.0167
Leishmania major extracellular receptor, putative 0.0033 0.0176 0.0822
Trichomonas vaginalis chromobox protein, putative 0.0099 0.0842 0.2001
Echinococcus granulosus transcription factor Dp 1 0.0034 0.0189 0.0225
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.017 0.04
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0032
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Onchocerca volvulus 0.0029 0.014 0.0388
Mycobacterium leprae Probable lipase LipE 0.0023 0.0077 0.058
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.014 0.014
Onchocerca volvulus 0.0033 0.0176 0.0496
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0272 0.1274
Brugia malayi Guanylyl cyclase protein 23 0.0033 0.0176 0.0413
Brugia malayi ecdysteroid receptor 0.0025 0.0103 0.0238
Loa Loa (eye worm) hypothetical protein 0.0061 0.0462 0.0547
Echinococcus granulosus lamin dm0 0.0016 0.0011 0.0013
Entamoeba histolytica hypothetical protein 0.0016 0.0013 0.0051
Echinococcus granulosus g protein coupled receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0009
Echinococcus granulosus tar DNA binding protein 0.0054 0.0388 0.0462
Plasmodium vivax importin-beta 2, putative 0.008 0.0652 0.7133
Onchocerca volvulus 0.0029 0.014 0.0388
Echinococcus multilocularis beta LACTamase domain containing family member 0.0023 0.0077 0.0077
Schistosoma mansoni lamin 0.0016 0.0011 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0103 0.0122
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.014 0.0167
Leishmania major glycerol uptake protein, putative 0.0018 0.003 0.0134
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0016 0.0013 0.0134
Onchocerca volvulus 0.035 0.3345 1
Onchocerca volvulus 0.0029 0.014 0.0388
Echinococcus multilocularis lamin 0.0016 0.0011 0.0011
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0016 0.0013 0.0134
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0058 0.0434 0.1028
Echinococcus granulosus allatostatin A receptor 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus granulosus pyruvate kinase 0.0068 0.0527 0.0627
Brugia malayi GNT-I family protein 0.0091 0.0758 0.1801
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0018 0.003 0.0035
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0018 0.003 0.0035
Onchocerca volvulus 0.0029 0.014 0.0388
Brugia malayi MBOAT family protein 0.0018 0.003 0.0064
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.014 0.0164
Onchocerca volvulus 0.0029 0.014 0.0388
Brugia malayi intermediate filament protein 0.0016 0.0011 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0112 0.0971 0.2309
Brugia malayi GnHR receptor homolog 0.0029 0.014 0.0327
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0068 0.0528 0.2482
Echinococcus multilocularis neuropeptide receptor 0.0029 0.014 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.017 0.0796
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0272 0.0642
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0103 0.0122
Trypanosoma brucei importin beta-1 subunit, putative 0.008 0.0652 0.3064
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0527 0.0624
Brugia malayi chromobox protein homolog 3 0.0056 0.0407 0.0963
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0206
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0103 0.0122
Schistosoma mansoni opsin-like receptor 0.0029 0.014 0.0167
Entamoeba histolytica Ran family GTPase 0.0042 0.0272 0.1268
Brugia malayi Melatonin receptor type 1A 0.0029 0.014 0.0327
Brugia malayi serine/threonine-protein kinase plk-2 0.0228 0.2125 0.5059
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.002 0.0049 0.0529
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0176 0.0206
Echinococcus granulosus translational activator gcn1 0.0015 0.0003 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0049 0.0227
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.014 0.0167
Brugia malayi nuclear receptor NHR-88 0.0025 0.0103 0.0238
Loa Loa (eye worm) hypothetical protein 0.0078 0.0631 0.0749
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0103 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0103 0.0119
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0078 0.0631 0.0631
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0013 0.0026
Echinococcus multilocularis metabotropic glutamate receptor 2 0.029 0.2743 0.2743
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.014 0.0164
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0198 0.2146
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0029 0.014 0.0167
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0106 0.0913 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0407 0.0963
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.017 0.04
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0033 0.0176 0.0413
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.014 0.0167
Echinococcus multilocularis pyruvate kinase 0.0068 0.0527 0.0527
Plasmodium vivax pyruvate kinase, putative 0.0068 0.0527 0.5758
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0058 0.0434 0.2038
Echinococcus granulosus pyruvate kinase 0.0035 0.0198 0.0236
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.0016
Echinococcus granulosus pyruvate kinase 0.0068 0.0527 0.0627
Schistosoma mansoni myosin xvIII 0.0029 0.014 0.0167
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0016 0.0013 0.0026
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.014 0.0167
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0016 0.0013 0.0118
Schistosoma mansoni neuropeptide receptor 0.0029 0.014 0.0167
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0272 0.2957
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0103 0.0122
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.017 0.0796
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.017 0.04
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0254 0.0303
Echinococcus granulosus glutamate receptor 2 0.0033 0.0176 0.0209
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.014 0.0388
Echinococcus multilocularis somatostatin receptor 0.0029 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.017 0.04
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.0028 0.0033
Onchocerca volvulus 0.0029 0.014 0.0388
Schistosoma mansoni hypothetical protein 0.0131 0.1156 0.1376
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0103 0.0238
Entamoeba histolytica hypothetical protein, conserved 0.0018 0.003 0.0127
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0051
Brugia malayi Dopamine receptor protein 2 0.0029 0.014 0.0327
Echinococcus granulosus neuropeptide receptor 0.0029 0.014 0.0167
Onchocerca volvulus 0.0029 0.014 0.0388
Echinococcus multilocularis geminin 0.0106 0.0914 0.0914
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0103 0.0103
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0018 0.003 0.003
Echinococcus multilocularis serotonin receptor 0.0029 0.014 0.014
Echinococcus multilocularis musashi 0.0016 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0103 0.0119
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0198 0.2158
Echinococcus multilocularis allatostatin A receptor 0.0029 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0131 0.1156 0.1156
Schistosoma mansoni pyruvate kinase 0.0068 0.0527 0.0627
Leishmania major glycerol uptake protein, putative 0.0018 0.003 0.0134
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.002 0.0049 0.0115
Schistosoma mansoni sterol O-acyltransferase 1 0.0018 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.03 0.2849 0.339
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0016 0.0011 0.0009
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0103 0.0276
Echinococcus multilocularis g protein coupled receptor 0.0029 0.014 0.014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0045 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.014 0.014
Schistosoma mansoni importin beta-1 0.008 0.0652 0.0776
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Loa Loa (eye worm) transcription factor SMAD2 0.0075 0.06 0.0712
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.014 0.014
Mycobacterium ulcerans lipase LipD 0.0023 0.0077 0.0181
Brugia malayi RNA recognition motif domain containing protein 0.0054 0.0388 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0193 0.1782 0.4242
Entamoeba histolytica serine/threonine protein kinase, putative 0.0228 0.2125 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.017 0.079
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0106 0.0913 0.1087
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0144 0.1289 0.1533
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.014 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0103 0.0119
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.014 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0228 0.2125 0.5059
Schistosoma mansoni alpha-glucosidase 0.0124 0.1089 0.1297
Echinococcus granulosus Chromobox protein 3 0.0016 0.0013 0.0016
Schistosoma mansoni hypothetical protein 0.0061 0.0462 0.055
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0106 0.0913 1
Onchocerca volvulus 0.0023 0.0077 0.02
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0106 0.0913 0.1087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.014 0.0167
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0272 0.2968
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1258 0.1498
Brugia malayi Protein cec-1. 0.0016 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0338
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0018 0.003 0.003
Trichomonas vaginalis chromobox protein, putative 0.006 0.0449 0.1064
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0044 0.0292 0.0292
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0103 0.0238
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.017 0.04
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.017 0.0796
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0164
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0039 0.024 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.2125 0.253
Loa Loa (eye worm) MBOAT family protein 0.0018 0.003 0.0032
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0058 0.0434 0.2032
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.014 0.0327
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.014 0.0327
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0032
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0018 0.003 0.0035
Schistosoma mansoni ran 0.0042 0.0272 0.0324
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0176 0.0176
Brugia malayi Valyl-tRNA synthetase 0.0016 0.0013 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0013 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.014 0.014
Echinococcus granulosus Chromo domain 0.0016 0.0013 0.0016
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0018 0.003 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0407 0.0963
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0016 0.0013 0.0013
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.014 0.0327
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.014 0.014
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0176 0.0176
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0058 0.0434 0.0434
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.014 0.014
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.014 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.014 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0206
Schistosoma mansoni amine GPCR 0.0029 0.014 0.0167
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0039 0.024 0.024
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0058 0.0434 0.0514
Mycobacterium ulcerans hypothetical protein 0.0023 0.0077 0.0181
Mycobacterium leprae Probable pyruvate kinase PykA 0.0068 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0631 0.0749
Schistosoma mansoni intermediate filament proteins 0.0016 0.0011 0.0013
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0527 0.1548
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.014 0.0164

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.9 nM Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assay ChEMBL. 24070783
Ratio (binding) = 2.9 Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assay relative to (+/-)-N-(1-(benzo[d][1,3]dioxol-5-yl)ethyl)-3-(2-chlorophenyl)acrylamide ChEMBL. 24070783

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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