Detailed information for compound 1791965

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 510.993 | Formula: C25H23ClN4O4S
  • H donors: 2 H acceptors: 3 LogP: 4.57 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc2c(c1)c(/C=N/NS(=O)(=O)c1ccc(cc1)C)cn2CC(=O)Nc1ccc(cc1)Cl
  • InChi: 1S/C25H23ClN4O4S/c1-17-3-10-22(11-4-17)35(32,33)29-27-14-18-15-30(24-12-9-21(34-2)13-23(18)24)16-25(31)28-20-7-5-19(26)6-8-20/h3-15,29H,16H2,1-2H3,(H,28,31)/b27-14+
  • InChiKey: ICMBSJAYAJYXCA-MZJWZYIUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Potassium voltage-gated channel protein Shaker, putative Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel subfamily A member 5, putative Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative Get druggable targets OG5_127659 All targets in OG5_127659
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis voltage gated potassium channel potassium voltage-gated channel, shaker-related subfamily, member 5 613 aa 521 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum pyruvate kinase 0.0459 0.4739 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0269 0.0567
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0014
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0047 0.0084
Brugia malayi PHD-finger family protein 0.0026 0.0142 0.0285
Schistosoma mansoni hypothetical protein 0.009 0.0818 0.1726
Loa Loa (eye worm) hypothetical protein 0.0284 0.2885 0.5803
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.013 0.0261
Giardia lamblia Pyruvate kinase 0.0235 0.2365 0.494
Brugia malayi nuclear receptor NHR-88 0.0014 0.0008 0.0016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0008 0.0017
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0008 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0269 0.0567
Onchocerca volvulus 0.0014 0.0007 0.0015
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0007 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0284 0.2885 0.5803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0189 0.0381
Giardia lamblia GTOR 0.0041 0.0302 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0157 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0051
Entamoeba histolytica pyruvate kinase, putative 0.032 0.3263 1
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0651 0.1361
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0269 0.0541
Echinococcus granulosus GPCR family 2 0.009 0.0818 0.0818
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0069 0.0069
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0364 0.3735 0.3731
Mycobacterium tuberculosis Conserved protein 0.0036 0.0241 0.0493
Echinococcus granulosus intermediate filament protein 0.0025 0.013 0.013
Brugia malayi nuclear hormone receptor 0.0029 0.0172 0.0346
Brugia malayi ecdysone receptor 0.0014 0.0008 0.0016
Echinococcus granulosus lamin dm0 0.0025 0.013 0.013
Entamoeba histolytica cysteine protease, putative 0.0019 0.0069 0.021
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0651 0.1361
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Leishmania major hypothetical protein, conserved 0.0014 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.013 0.0261
Loa Loa (eye worm) hypothetical protein 0.0035 0.0233 0.0468
Loa Loa (eye worm) latrophilin receptor protein 2 0.009 0.0818 0.1645
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0212 0.0433
Schistosoma mansoni pyruvate kinase 0.0459 0.4739 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0026 0.0051
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0172 0.0363
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0172 0.0172
Onchocerca volvulus 0.0019 0.0069 0.0145
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0302 0.0608
Loa Loa (eye worm) beta-lactamase 0.0036 0.0241 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0172 0.0346
Brugia malayi tailless protein 0.0014 0.0008 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0212 0.0433
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0047 0.5
Brugia malayi steroid hormone receptor 0.0029 0.0172 0.0346
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0241 0.0493
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0008 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0212 0.0426
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0358 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Mycobacterium tuberculosis Conserved protein 0.0036 0.0241 0.0493
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0051
Loa Loa (eye worm) pyruvate kinase 0.0459 0.4739 0.953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0212 0.0426
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0026 0.0054
Echinococcus multilocularis pyruvate kinase 0.0459 0.4739 0.4735
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Leishmania major DNA polymerase eta, putative 0.0038 0.0269 0.0553
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0026 0.0054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.009 0.0818 0.0812
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0305 0.0305
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.013 0.0261
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0008 0.0001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0305 0.0613
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0137 0.1314 0.1307
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0047 0.0094
Onchocerca volvulus 0.0019 0.0069 0.0145
Echinococcus granulosus dna polymerase kappa 0.0038 0.0269 0.0269
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0305 0.0629
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0172 0.0363
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0241 0.0241
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0014 0.0009 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0047 0.0047
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0241 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Leishmania major cathepsin L-like protease 0.0074 0.0651 0.1361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0099 0.02
Brugia malayi hypothetical protein 0.0014 0.0008 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0172 0.0165
Echinococcus granulosus pyruvate kinase 0.0459 0.4739 0.4739
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0358 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0069 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0233 0.0468
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0269 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0172 0.0346
Loa Loa (eye worm) MH2 domain-containing protein 0.0107 0.1003 0.2018
Schistosoma mansoni ap endonuclease 0.0017 0.0047 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0233 0.0468
Schistosoma mansoni ap endonuclease 0.0017 0.0047 0.0098
Loa Loa (eye worm) hypothetical protein 0.0047 0.0358 0.072
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0172 0.0363
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0233 0.0476
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0008 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.0915 0.0909
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0358 0.0742
Entamoeba histolytica hypothetical protein 0.019 0.1877 0.5754
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0008 0.0016
Brugia malayi Pyruvate kinase, muscle isozyme 0.0459 0.4739 0.953
Schistosoma mansoni bromodomain containing protein 0.0062 0.052 0.1098
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0026 0.0018
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0172 0.0172
Mycobacterium ulcerans beta-lactamase 0.0036 0.0241 0.0493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0008 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0189 0.0381
Onchocerca volvulus 0.0014 0.0007 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0172 0.0346
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0241 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0172 0.0346
Trypanosoma brucei ISWI complex protein 0.0014 0.0012 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0172 0.0346
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.019 0.1877 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0009 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0172 0.0165
Loa Loa (eye worm) hypothetical protein 0.0036 0.0241 0.0484
Trichomonas vaginalis esterase, putative 0.0036 0.0241 0.0484
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0269 0.0824
Echinococcus multilocularis pyruvate kinase 0.0235 0.2365 0.2359
Loa Loa (eye worm) hypothetical protein 0.0036 0.0241 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0099 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0172 0.0346
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0014 0.0009 0.0004
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0345 0.3527 0.7093
Mycobacterium tuberculosis Conserved protein 0.0036 0.0241 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0122 0.0246
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0138
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0269 0.0553
Loa Loa (eye worm) hypothetical protein 0.0104 0.0963 0.1938
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0172 0.0346
Brugia malayi Pyruvate kinase, M2 isozyme 0.0459 0.4739 0.953
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.3395 0.6828
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0269 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0099 0.02
Schistosoma mansoni zinc finger protein 0.0014 0.0012 0.0025
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0009 0.0004
Toxoplasma gondii pyruvate kinase PyKII 0.0235 0.2365 0.4983
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0007 0.0014
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0041 0.0302 0.0926
Brugia malayi MH2 domain containing protein 0.0107 0.1003 0.2018
Schistosoma mansoni transcription factor LCR-F1 0.019 0.1877 0.3962
Echinococcus granulosus pyruvate kinase 0.0459 0.4739 0.4739
Toxoplasma gondii exonuclease III APE 0.0017 0.0047 0.0084
Loa Loa (eye worm) pyruvate kinase 0.0097 0.0889 0.1788
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0172 0.0363
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0269 0.0541
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0172 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0099 0.0199
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0172 0.0363
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0029 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0148 0.0297
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0269 0.0553
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0033 0.0212 0.0434
Onchocerca volvulus 0.0025 0.013 0.0274
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0358 0.0742
Schistosoma mansoni coup transcription factor 0.0029 0.0172 0.0363
Brugia malayi beta-lactamase family protein 0.0036 0.0241 0.0484
Loa Loa (eye worm) hypothetical protein 0.0046 0.0346 0.0696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0269 0.0553
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.013
Mycobacterium ulcerans hypothetical protein 0.0036 0.0241 0.0493
Brugia malayi nuclear receptor RXR 0.0014 0.0008 0.0016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0047 0.0084
Brugia malayi Pre-SET motif family protein 0.003 0.0178 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Schistosoma mansoni intermediate filament proteins 0.0025 0.013 0.0274
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.009 0.0818 0.0818
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0284 0.2885 0.5803
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0358 0.0742
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0172 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0376 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0099 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0189 0.0381
Giardia lamblia Pyruvate kinase 0.0459 0.4739 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.019 0.1877 0.1877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0238 0.0478
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0269 0.0553
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0302 0.0608
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0008 0.0008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0269 0.0269
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0358 0.072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0069 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Loa Loa (eye worm) bromodomain containing protein 0.002 0.007 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0099 0.02
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0172 0.0346
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0026 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0241 0.0493
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0005 0.001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0029 0.0062
Onchocerca volvulus 0.0047 0.0358 0.0756
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0358 0.0742
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0172 0.0363
Onchocerca volvulus 0.003 0.0178 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0172 0.0346
Onchocerca volvulus 0.0025 0.013 0.0274
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0138
Plasmodium vivax pyruvate kinase, putative 0.0459 0.4739 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Toxoplasma gondii cathepsin CPL 0.0019 0.0069 0.013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0358 0.0742
Entamoeba histolytica hypothetical protein 0.019 0.1877 0.5754
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0142 0.0286
Echinococcus multilocularis cysteine protease 0.0019 0.0069 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0346 0.0731
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0008 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0172 0.0165
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0269 0.0541
Brugia malayi Latrophilin receptor protein 2 0.009 0.0818 0.1645
Onchocerca volvulus 0.0019 0.0069 0.0145
Loa Loa (eye worm) hypothetical protein 0.014 0.1345 0.2706
Toxoplasma gondii hypothetical protein 0.0046 0.0346 0.0716
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0051
Trypanosoma brucei unspecified product 0.0038 0.0269 0.0553
Echinococcus multilocularis GPCR, family 2 0.009 0.0818 0.0812
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0138
Loa Loa (eye worm) hypothetical protein 0.0038 0.0269 0.0541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Loa Loa (eye worm) hypothetical protein 0.009 0.0818 0.1645
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0358 0.0742
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0104 0.0963 0.0963
Brugia malayi nuclear receptor NHR-88 0.0029 0.0172 0.0346
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0029 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0302 0.0608
Leishmania major cathepsin L-like protease 0.0074 0.0651 0.1361
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0345 0.3527 0.7442
Brugia malayi nuclear receptor RXR 0.0015 0.0026 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0041 0.0302 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0172 0.0346
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0008 0.0017
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0269 0.0553
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0007 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0142 0.0286
Plasmodium vivax vivapain-2 0.0019 0.0069 0.013
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2284 0.4813
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0233 0.0476
Schistosoma mansoni thyroid hormone receptor 0.0394 0.4046 0.8539
Loa Loa (eye worm) cysteine protease 0.0019 0.0069 0.0138
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.009 0.0818 0.0818
Plasmodium falciparum histone acetyltransferase GCN5 0.0036 0.0246 0.0506
Echinococcus multilocularis zinc finger protein 0.0021 0.0089 0.0082
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0033 0.0212 0.0434
Loa Loa (eye worm) ctsf protein 0.0019 0.0069 0.0138
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0051
Schistosoma mansoni cellular tumor antigen P53 0.014 0.1345 0.2839
Onchocerca volvulus 0.0036 0.0241 0.0508
Toxoplasma gondii ABC1 family protein 0.0036 0.0241 0.0493
Onchocerca volvulus 0.0014 0.0008 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0358 0.0742
Onchocerca volvulus 0.0014 0.0007 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0241 0.0484
Echinococcus multilocularis pyruvate kinase 0.0459 0.4739 0.4735
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0345 0.3527 0.3522
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0241 0.0493
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0041 0.0302 0.0624
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0305 0.0629
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0481 0.4972 1
Onchocerca volvulus Pyruvate kinase homolog 0.0459 0.4739 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0008 0.0008
Schistosoma mansoni DNA polymerase eta 0.0038 0.0269 0.0567
Trichomonas vaginalis glucosylceramidase, putative 0.0315 0.3215 0.6465
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0069 0.0138
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0172 0.0363
Schistosoma mansoni hypothetical protein 0.019 0.1877 0.3962
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0099 0.0199
Echinococcus multilocularis musashi 0.0025 0.013 0.0123
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0069 0.0069
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0069 0.013
Brugia malayi beta-lactamase 0.0036 0.0241 0.0484
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0041 0.0302 0.0926
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0212 0.0433
Loa Loa (eye worm) hypothetical protein 0.0194 0.1928 0.3879
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0172 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0172 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0122 0.0246
Loa Loa (eye worm) oxidoreductase 0.0014 0.0007 0.0014
Brugia malayi hypothetical protein 0.019 0.1877 0.3776
Loa Loa (eye worm) hypothetical protein 0.0043 0.0317 0.0637
Echinococcus multilocularis lamin 0.0025 0.013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Brugia malayi intermediate filament protein 0.0025 0.013 0.0261
Loa Loa (eye worm) hypothetical protein 0.0035 0.0233 0.0468
Echinococcus multilocularis lamin dm0 0.0025 0.013 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0651 0.1361
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0069 0.0138
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.013
Brugia malayi hypothetical protein 0.0015 0.0026 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.0315 0.3215 0.6465
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0241 0.0493
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0172 0.0165
Trypanosoma brucei pyruvate kinase 1, putative 0.0459 0.4739 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0138
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0241 0.0493
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0212 0.0433
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0481 0.4972 1
Onchocerca volvulus 0.0029 0.0172 0.0363
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0069 0.021
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0284 0.0585
Brugia malayi latrophilin 2 splice variant baaae 0.0194 0.1928 0.3879
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Onchocerca volvulus 0.0014 0.0008 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0358 0.072
Mycobacterium ulcerans lipase LipD 0.0036 0.0241 0.0493
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0069 0.0145
Onchocerca volvulus 0.0036 0.0241 0.0508
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0283 0.2867 0.6045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0358 0.0742
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0346 0.0339
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0014
Trypanosoma cruzi ISWI complex protein 0.0014 0.0012 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0009 0.0018
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0008 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.009 0.0818 0.0812
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0069 0.0145
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0172 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0315 0.3215 0.6465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0009 0.0018
Brugia malayi Bromodomain containing protein 0.0073 0.0636 0.1279
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0047 0.0084
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0008 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0069 0.0061
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0007 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0007 0.0014
Schistosoma mansoni zinc finger protein 0.0014 0.0008 0.0017
Echinococcus granulosus histone acetyltransferase KAT2B 0.0131 0.125 0.125
Loa Loa (eye worm) pyruvate kinase-PB 0.032 0.3263 0.6562
Trichomonas vaginalis glucosylceramidase, putative 0.0332 0.3395 0.6828
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0358 0.072
Plasmodium vivax SET domain protein, putative 0.003 0.0178 0.0361
Schistosoma mansoni hypothetical protein 0.009 0.0818 0.1726
Leishmania major phosphatidylinositol 3-kinase, putative 0.0014 0.0009 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0241 0.0234
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0069 0.013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0149 0.1445 0.3038
Onchocerca volvulus 0.0036 0.0241 0.0508
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0241 0.0484
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0008 0.0017
Trypanosoma cruzi pyruvate kinase 2, putative 0.0459 0.4739 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0283 0.2867 0.6045
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0069 0.013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0172 0.0346
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Schistosoma mansoni nuclear receptor 0.0014 0.0008 0.0017
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0459 0.4739 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0007 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0069 0.021
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0069 0.013
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0305 0.0629
Onchocerca volvulus 0.0019 0.0069 0.0145
Schistosoma mansoni hypothetical protein 0.0087 0.0781 0.1648
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0051
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0041 0.0302 0.0302
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0241 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0346 0.0731
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.007 0.0132
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0651 0.1361
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0172 0.0346
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0305 0.0613
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.207 0.4164
Schistosoma mansoni lamin 0.0025 0.013 0.0274
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0172 0.0172
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0178 0.0376
Loa Loa (eye worm) hypothetical protein 0.0345 0.3527 0.7093
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0047 0.0094
Trypanosoma brucei pyruvate kinase 1 0.0459 0.4739 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0166 0.0166
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0017 0.0044 0.0079
Schistosoma mansoni lamin 0.0025 0.013 0.0274
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Schistosoma mansoni nuclear receptor 0.0014 0.0008 0.0017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0172 0.0363
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0008 0.0016
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0172 0.0172
Onchocerca volvulus Pyruvate kinase homolog 0.0459 0.4739 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0008 0.0016
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0008 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0172 0.0363
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0026 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0189 0.0381
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0241 0.0493
Loa Loa (eye worm) transcription factor SMAD2 0.0107 0.1003 0.2018
Onchocerca volvulus Glucosylceramidase homolog 0.0315 0.3215 0.6784
Brugia malayi pyruvate kinase, muscle isozyme 0.0097 0.0889 0.1788
Echinococcus granulosus fetal alzheimer antigen falz 0.0021 0.0084 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0142 0.0286
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0041 0.0302 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0481 0.4972 1
Trichomonas vaginalis glucosylceramidase, putative 0.0481 0.4972 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0047 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0212 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0009 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0212 0.0426
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0047 0.0084
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.0246 0.0426
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0172 0.0172
Onchocerca volvulus 0.0019 0.0069 0.0145
Entamoeba histolytica acetyltransferase, GNAT family 0.0036 0.0246 0.0755
Entamoeba histolytica hypothetical protein 0.019 0.1877 0.5754
Onchocerca volvulus 0.0019 0.0069 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0315 0.3215 0.6465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0189 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0172 0.0346
Trypanosoma cruzi pyruvate kinase 2, putative 0.0459 0.4739 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0358 0.0742
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0047 0.0143
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0008 0.0016
Trichomonas vaginalis pyruvate kinase, putative 0.0459 0.4739 0.953
Brugia malayi acetyltransferase, GNAT family protein 0.0137 0.1314 0.2642
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0241 0.0484
Brugia malayi Calcitonin receptor-like protein seb-1 0.0284 0.2885 0.5803
Trypanosoma brucei unspecified product 0.0026 0.0142 0.0286
Leishmania major cathepsin L-like protease 0.0019 0.0069 0.013
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.0009 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0138
Schistosoma mansoni pyruvate kinase 0.0459 0.4739 1
Schistosoma mansoni hypothetical protein 0.009 0.0818 0.1726
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0009 0.0018
Trypanosoma brucei DNA polymerase beta thumb, putative 0.004 0.0284 0.0585
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0172 0.0363
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0029 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0172 0.0346
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0269 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0481 0.4972 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0172 0.0172
Plasmodium vivax pyruvate kinase 2, putative 0.0235 0.2365 0.4983
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0009 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0069 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Onchocerca volvulus 0.0019 0.0069 0.0145
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0241 0.0493
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0172 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0189 0.0381
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0485 0.0485
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0069 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0172 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0069 0.0138
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0047 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Loa Loa (eye worm) hypothetical protein 0.0066 0.0559 0.1123
Trypanosoma brucei unspecified product 0.0026 0.0142 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.0315 0.3215 0.6465
Trypanosoma brucei RNA helicase, putative 0.0087 0.0781 0.1635
Loa Loa (eye worm) hypothetical protein 0.032 0.3263 0.6562
Echinococcus granulosus pyruvate kinase 0.0235 0.2365 0.2365
Schistosoma mansoni thyroid hormone receptor 0.0394 0.4046 0.8539
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0241 0.0493
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0178 0.0376
Mycobacterium ulcerans hypothetical protein 0.0047 0.0358 0.0742
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0963 0.2033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0241 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0269 0.0553
Echinococcus multilocularis potassium voltage gated channel protein 0.0104 0.0963 0.0957
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0172 0.0165
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0358 0.0742
Echinococcus multilocularis pyruvate kinase 0.0235 0.2365 0.2359
Leishmania major cathepsin L-like protease 0.0074 0.0651 0.1361
Brugia malayi hypothetical protein 0.0014 0.0008 0.0016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0269 0.0541
Trichomonas vaginalis pyruvate kinase, putative 0.0459 0.4739 0.953
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0216 0.0209
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2375 0.4777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0212 0.0426
Loa Loa (eye worm) hypothetical protein 0.0036 0.0241 0.0484
Onchocerca volvulus 0.0236 0.2375 0.5013
Loa Loa (eye worm) pyruvate kinase 0.0459 0.4739 0.953
Plasmodium falciparum pyruvate kinase 2 0.0235 0.2365 0.4983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Loa Loa (eye worm) DR-78 0.0014 0.0008 0.0016
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0007 0.0015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0241 0.0493
Brugia malayi pyruvate kinase 0.0097 0.0889 0.1788
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0008 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0134 0.1284 0.2698
Mycobacterium leprae Probable lipase LipE 0.0036 0.0241 0.0493
Echinococcus multilocularis pyruvate kinase 0.0235 0.2365 0.2359
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0482 0.1004
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0008 0.0017
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0269 0.0262
Onchocerca volvulus 0.014 0.1345 0.2839
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0047 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.0358 0.072
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0241 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0358 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0014 0.0009 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0284 0.0585
Brugia malayi Bromodomain containing protein 0.0039 0.0274 0.0551
Leishmania major mitochondrial DNA polymerase beta 0.0283 0.2867 0.6045
Echinococcus multilocularis thyroid hormone receptor alpha 0.0394 0.4046 0.4042
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0008 0.0017
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0041 0.0302 0.0624
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0269 0.0553
Trichomonas vaginalis glucosylceramidase, putative 0.0315 0.3215 0.6465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Loa Loa (eye worm) hypothetical protein 0.0036 0.0241 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0189 0.0381
Echinococcus granulosus dna polymerase eta 0.0038 0.0269 0.0269
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0583 0.1216
Plasmodium vivax vivapain-2 0.0019 0.0069 0.013
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0358 0.1098
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.1284 0.2698
Echinococcus multilocularis cysteine protease 0.0019 0.0069 0.0061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0241 0.0493
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0358 0.072
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0241 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0302 0.0608
Loa Loa (eye worm) hypothetical protein 0.0459 0.4739 0.953
Giardia lamblia DINP protein human, muc B family 0.0038 0.0269 0.0474
Schistosoma mansoni hypothetical protein 0.0014 0.0012 0.0025
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0047 0.0094
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0963 0.2033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0233 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0172 0.0346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.009 0.0818 0.1645
Onchocerca volvulus Pyruvate kinase homolog 0.0459 0.4739 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0139 0.1337 0.2689
Schistosoma mansoni pyruvate kinase 0.0235 0.2365 0.499
Trichomonas vaginalis glucosylceramidase, putative 0.0481 0.4972 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0459 0.4739 1
Brugia malayi conserved hypotetical protein 0.0014 0.0008 0.0016
Entamoeba histolytica hypothetical protein 0.019 0.1877 0.5754
Loa Loa (eye worm) intermediate filament protein 0.0025 0.013 0.0261
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0485 0.0478
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0047 0.004
Echinococcus granulosus pyruvate kinase 0.0235 0.2365 0.2365
Leishmania major pyruvate kinase 0.0459 0.4739 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0021 0.0084 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0047 0.0084
Echinococcus multilocularis dna polymerase eta 0.0038 0.0269 0.0262
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.1284 0.2698
Loa Loa (eye worm) hypothetical protein 0.0036 0.0241 0.0484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0241 0.0508
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0041 0.0302 0.0624
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0172 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0651 0.1361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0172 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0172 0.0346
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0008 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0358 0.0742
Schistosoma mansoni zinc finger protein 0.0021 0.0089 0.0188
Echinococcus granulosus pyruvate kinase 0.0235 0.2365 0.2365
Echinococcus multilocularis tumor protein p63 0.0954 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0172 0.0346
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Toxoplasma gondii target of rapamycin (TOR), putative 0.0031 0.0189 0.0385
Echinococcus multilocularis pyruvate kinase 0.0362 0.3711 0.3707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0269 0.0553
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0041 0.0302 0.0624
Trichomonas vaginalis glucosylceramidase, putative 0.0481 0.4972 1
Loa Loa (eye worm) fibroinase 0.0019 0.0069 0.0138
Leishmania major hypothetical protein, conserved 0.0036 0.0241 0.0493
Loa Loa (eye worm) pyruvate kinase 0.0459 0.4739 0.953
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0014 0.0009 0.0004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0008 0.0008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0041 0.0302 0.0638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Brugia malayi nuclear receptor NHR-67 0.0014 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.009 0.0818 0.1726
Echinococcus granulosus lamin 0.0025 0.013 0.013
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0358 0.0742
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0069 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0172 0.0165
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0172 0.0165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0047 0.0084
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0233 0.0476
Brugia malayi nuclear hormone receptor 0.0014 0.0008 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0241 0.0484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0069 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0069 0.0145
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.0019 0.0065 0.0136
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0047 0.0084
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0346 0.0346
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0241 0.0493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0069 0.0138
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0065 0.013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0302 0.0608
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0007 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0172 0.0346
Brugia malayi ecdysteroid receptor 0.0029 0.0172 0.0346
Trypanosoma cruzi ISWI complex protein 0.0014 0.0012 0.001
Brugia malayi Cathepsin L-like precursor 0.0019 0.0069 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0026 0.0051
Brugia malayi hypothetical protein 0.0015 0.0026 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0172 0.0346
Trichomonas vaginalis glucosylceramidase, putative 0.0315 0.3215 0.6465
Schistosoma mansoni hypothetical protein 0.0194 0.1928 0.407
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0137 0.1314 0.2772
Brugia malayi Pre-SET motif family protein 0.0208 0.207 0.4164
Echinococcus granulosus potassium voltage gated channel protein 0.0104 0.0963 0.0963
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0138
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0069 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0009 0.0018
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0041 0.0302 0.0624
Schistosoma mansoni hypothetical protein 0.0364 0.3735 0.7882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0241 0.0493
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0172 0.0363
Mycobacterium ulcerans pyruvate kinase 0.0459 0.4739 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0007 0.0014
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0005 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0172 0.0363
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0069 0.0138
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0241 0.0484
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0172 0.0363
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0284 0.0585
Leishmania major pyruvate kinase 0.0459 0.4739 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0033 0.0212 0.0434
Loa Loa (eye worm) hypothetical protein 0.0041 0.0298 0.0599
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0358 0.1098
Leishmania major DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0172 0.0172
Echinococcus granulosus zinc finger protein 0.0021 0.0089 0.0089
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0283 0.2867 0.6045
Onchocerca volvulus 0.0014 0.0007 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0481 0.4972 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0178 0.0361
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0345 0.3527 0.3527
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0016
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0104 0.0963 0.1938
Mycobacterium ulcerans hypothetical protein 0.0149 0.1445 0.3038
Echinococcus granulosus cathepsin l1 0.0019 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0482
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0008 0.0001
Brugia malayi beta-lactamase family protein 0.0036 0.0241 0.0484
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0178 0.0171
Loa Loa (eye worm) hypothetical protein 0.0035 0.0233 0.0468
Toxoplasma gondii pyruvate kinase PyK1 0.0459 0.4739 1
Loa Loa (eye worm) acetyltransferase 0.0137 0.1314 0.2642
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0021 0.0084 0.0176
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0269 0.0553
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.0251
Chlamydia trachomatis pyruvate kinase 0.0459 0.4739 1
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0069 0.0145
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0364 0.3735 0.3735
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0269 0.0553

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.51 uM Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique ChEMBL. 24071446
IC50 (binding) = 418.35 uM Inhibition of human ERG channel expressed in CHO cells by whole cell patch clamp technique ChEMBL. 24071446
Inhibition (binding) Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp technique ChEMBL. 24071446

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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