Detailed information for compound 1792153

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.537 | Formula: C30H26N2O7
  • H donors: 1 H acceptors: 4 LogP: 4.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCn1c(=O)c(cc2c1ccc(c2)OC)C1C(=C(N)OC2=C1C(=O)c1c(C2=O)cccc1)C(=O)OC(C)C
  • InChi: 1S/C30H26N2O7/c1-5-12-32-21-11-10-17(37-4)13-16(21)14-20(29(32)35)22-23-25(33)18-8-6-7-9-19(18)26(34)27(23)39-28(31)24(22)30(36)38-15(2)3/h5-11,13-15,22H,1,12,31H2,2-4H3
  • InChiKey: YFQISSPWMMUWJH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.0158 0.1712 0.1748
Brugia malayi diacylglycerol acyltransferase 0.0141 0.1499 0.1599
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0037 0.0255 0.0675
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1203 1
Schistosoma mansoni amine GPCR 0.0158 0.1712 0.1788
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0096 0.0102
Leishmania major cytochrome p450-like protein 0.0037 0.0255 0.251
Schistosoma mansoni neuropeptide receptor 0.0158 0.1712 0.1788
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0066
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0356 0.166
Echinococcus multilocularis sex peptide receptor 0.0158 0.1712 0.1638
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0108 0.0443
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0108 0.0765
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.1712 0.1748
Mycobacterium leprae putative cytochrome p450 0.0037 0.0255 0.062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0197 0.028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0256 0.0169
Brugia malayi Latrophilin receptor protein 2 0.0111 0.1142 0.1217
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0256 0.2702
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0001
Onchocerca volvulus 0.0158 0.1712 0.8851
Onchocerca volvulus 0.0158 0.1712 0.8851
Brugia malayi RE15519p 0.0158 0.1712 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0197 0.028
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0037 0.0255 0.0675
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0158 0.1712 0.1802
Onchocerca volvulus 0.0158 0.1712 0.8851
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1712 0.1748
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0606 0.0602
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0187 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0224 0.0351
Schistosoma mansoni inositol monophosphatase 0.0036 0.0237 0.0208
Echinococcus multilocularis serotonin receptor 0.0158 0.1712 0.1638
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1712 0.1788
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.1712 0.1638
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0231 0.0369
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.1712 0.1788
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0628 0.8543
Brugia malayi neuropeptide F receptor 0.0158 0.1712 0.1826
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0037 0.0255 0.0666
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0158 0.1712 0.1748
Brugia malayi diacylglycerol acyltransferase family protein 0.009 0.0885 0.0944
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.009 0.0885 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0351 0.4033 0.43
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0037 0.0255 0.0675
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0332 0.3429
Brugia malayi Cytochrome P450 family protein 0.0056 0.0478 0.0509
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0089 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0231 0.0369
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0096 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0702 0.1592
Loa Loa (eye worm) MBOAT family protein 0.0024 0.0089 0.0066
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0628 0.0627
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0255 0.251
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0037 0.0255 0.0675
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0356 0.3709
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0001
Schistosoma mansoni hypothetical protein 0.0158 0.1712 0.1788
Onchocerca volvulus 0.0158 0.1712 0.8851
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.1712 0.1638
Brugia malayi GnHR receptor homolog 0.0158 0.1712 0.1826
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0187 0.1706
Brugia malayi MBOAT family protein 0.0024 0.0089 0.0095
Loa Loa (eye worm) hypothetical protein 0.0117 0.1214 0.127
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0158 0.1712 0.1638
Trypanosoma brucei trypanothione reductase 0.0046 0.0356 0.3856
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.1006 0.0926
Echinococcus granulosus 7tm_1 domain containing protein 0.0158 0.1712 0.1748
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0351 0.4033 0.43
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0256 1
Schistosoma mansoni histamine h1 receptor 0.0158 0.1712 0.1788
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0158 0.1712 0.1788
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0281 0.0194
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.1712 0.1802
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.1712 0.1638
Toxoplasma gondii exonuclease III APE 0.0038 0.0256 0.1461
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0256 0.0434
Echinococcus granulosus transcription factor Dp 1 0.004 0.0281 0.0207
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0231 0.0369
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0478 0.5162
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0037 0.0255 0.0666
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.1712 0.1748
Schistosoma mansoni cytochrome P450 0.0037 0.0255 0.0226
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0224 0.215
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0096 0.0842
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0076
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0255 0.251
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0158 0.1712 0.1788
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1712 0.1748
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0066
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0037 0.0255 0.0666
Toxoplasma gondii hypothetical protein 0.0048 0.0379 0.2305
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0096 0.0056
Echinococcus granulosus hypothetical protein 0.0158 0.1712 0.1748
Echinococcus granulosus somatostatin receptor 0.0158 0.1712 0.1748
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0158 0.1712 0.1748
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0187 0.065
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0256 0.0679
Brugia malayi TAR-binding protein 0.0135 0.1424 0.1518
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0024 0.0089 0.0049
Schistosoma mansoni hypothetical protein 0.0158 0.1712 0.1788
Onchocerca volvulus 0.0092 0.0917 0.4514
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0096 0.0622
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0187 0.0099
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0158 0.1712 0.1748
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0096 0.0073
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0187 0.1706
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0187 0.1706
Onchocerca volvulus 0.0158 0.1712 0.8851
Echinococcus granulosus sex peptide receptor 0.0158 0.1712 0.1748
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0037 0.0255 0.0666
Brugia malayi Cytochrome P450 family protein 0.0056 0.0478 0.0509
Loa Loa (eye worm) cytochrome P450 0.0037 0.0255 0.0243
Schistosoma mansoni neuropeptide f receptor 76f 0.0158 0.1712 0.1788
Echinococcus multilocularis 0.0037 0.0255 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0037 0.0255 0.251
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Echinococcus granulosus GPCR family 2 0.0111 0.1142 0.1134
Echinococcus granulosus neuropeptide receptor A26 0.0619 0.7261 0.772
Loa Loa (eye worm) MBOAT family protein 0.0024 0.0089 0.0066
Leishmania major glycerol uptake protein, putative 0.0024 0.0089 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0187 0.0986
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0158 0.1712 0.1638
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Onchocerca volvulus 0.0148 0.1581 0.8134
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0037 0.0255 0.0675
Loa Loa (eye worm) cytochrome P450 family protein 0.0118 0.1227 0.1283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0332 0.0631
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0478 0.0482
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0332 0.3582
Brugia malayi Glycosylation related protein 12, isoform 0.0041 0.0295 0.0315
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0024 0.0089 0.0066
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0158 0.1712 0.1638
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Entamoeba histolytica hypothetical protein 0.0076 0.072 1
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0041 0.0295 0.1729
Echinococcus granulosus intermediate filament protein 0.0053 0.0437 0.0375
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.012 0.1252 0.1174
Echinococcus granulosus geminin 0.0511 0.5955 0.6314
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0037 0.0255 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0197 0.028
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0037 0.0255 0.0675
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0158 0.1712 0.1788
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Loa Loa (eye worm) hypothetical protein 0.0176 0.1923 0.2028
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.1712 0.1638
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0795 0.938 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0187 0.0986
Loa Loa (eye worm) RNA binding protein 0.0135 0.1424 0.1493
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.1712 0.1788
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1728 0.1654
Onchocerca volvulus 0.0158 0.1712 0.8851
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni myosin xvIII 0.0158 0.1712 0.1788
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0478 0.0482
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0187 0.19
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.1142 0.1063
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0237 0.062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0295 0.0287
Schistosoma mansoni inositol monophosphatase 0.0036 0.0237 0.0208
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0037 0.0255 0.0675
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0256 0.0434
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0037 0.0255 0.0666
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni intermediate filament proteins 0.0053 0.0437 0.0422
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1728 0.1654
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.1142 0.1134
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0024 0.0089 0.0049
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0187 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1424 0.1479
Echinococcus granulosus cytochrome P450 2K1 0.0037 0.0255 0.0179
Onchocerca volvulus 0.0158 0.1712 0.8851
Loa Loa (eye worm) hypothetical protein 0.0111 0.1142 0.1192
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus multilocularis serotonin receptor 0.0158 0.1712 0.1638
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.072 0.068
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1424 0.1479
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0108 0.0086
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0158 0.1712 0.1826
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0187 0.0099
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0037 0.0255 0.0666
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0231 0.0143
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0158 0.1712 0.1748
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0197 0.1053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0332 0.0631
Brugia malayi G-protein coupled receptor 0.0158 0.1712 0.1826
Brugia malayi MBOAT family protein 0.0024 0.0089 0.0095
Brugia malayi Melatonin receptor type 1A 0.0158 0.1712 0.1826
Schistosoma mansoni alpha glucosidase 0.0035 0.0231 0.0201
Loa Loa (eye worm) hypothetical protein 0.0351 0.4033 0.4283
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0332 0.3429
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1712 0.1788
Echinococcus multilocularis neuropeptide receptor 0.0158 0.1712 0.1638
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.011 0.0021
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0237 0.2485
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0096 0.011
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.009 0.0885 1
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0141 0.1499 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.1142 0.1063
Echinococcus multilocularis fmrfamide receptor 0.0158 0.1712 0.1638
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0231 0.0369
Loa Loa (eye worm) hypothetical protein 0.0052 0.0426 0.0426
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0037 0.0255 0.0675
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0037 0.0255 0.0666
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0.0478 0.1387
Schistosoma mansoni hypothetical protein 0.0511 0.5955 0.6332
Trypanosoma cruzi GUP1, putative 0.0024 0.0089 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0197 0.028
Schistosoma mansoni hypothetical protein 0.0111 0.1142 0.1177
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1203 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Brugia malayi glutathione reductase 0.0046 0.0356 0.0379
Schistosoma mansoni opsin-like receptor 0.0158 0.1712 0.1788
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0231 0.0218
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0356 0.1851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0116 0.0072
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0158 0.1712 0.1802
Echinococcus multilocularis somatostatin receptor 0.0158 0.1712 0.1638
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.1712 0.1802
Trypanosoma brucei glycerol uptake protein, putative 0.0024 0.0089 0.0761
Toxoplasma gondii melibiase subfamily protein 0.01 0.1006 0.6614
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0096 0.0056
Onchocerca volvulus 0.0158 0.1712 0.8851
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0628 0.0581
Trypanosoma cruzi glycerol uptake protein, putative 0.0024 0.0089 0.054
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0332 0.0326
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0037 0.0255 0.0666
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0332 0.3429
Schistosoma mansoni hypothetical protein 0.0158 0.1712 0.1788
Loa Loa (eye worm) TAR-binding protein 0.0135 0.1424 0.1493
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0332 0.0245
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0158 0.1712 0.1802
Plasmodium falciparum glutathione reductase 0.0046 0.0356 0.1851
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0231 0.2227
Echinococcus granulosus tachykinin peptides receptor 99D 0.0158 0.1712 0.1748
Echinococcus multilocularis orexin receptor type 2 0.0158 0.1712 0.1638
Onchocerca volvulus 0.0158 0.1712 0.8851
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0089 0.0001
Loa Loa (eye worm) glutaminase 2 0.028 0.3176 0.3367
Onchocerca volvulus 0.0158 0.1712 0.8851
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.1712 0.1788
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0037 0.0255 0.0675
Leishmania major glycerol uptake protein, putative 0.0024 0.0089 0.054
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0108 0.0982
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus multilocularis G-protein coupled receptor, putative 0.0158 0.1712 0.1638
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0332 0.3429
Loa Loa (eye worm) hypothetical protein 0.012 0.1252 0.131
Schistosoma mansoni lamin 0.0053 0.0437 0.0422
Brugia malayi G protein-coupled receptor F59B2.13 0.0158 0.1712 0.1826
Onchocerca volvulus 0.0158 0.1712 0.8851
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0606 0.0602
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0256 0.1142
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0356 0.0269
Echinococcus multilocularis GPCR, family 2 0.0111 0.1142 0.1063
Onchocerca volvulus 0.0158 0.1712 0.8851
Onchocerca volvulus 0.0053 0.0437 0.19
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0224 0.0351
Echinococcus granulosus lamin dm0 0.0053 0.0437 0.0375
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0224 0.2334
Leishmania major glycerol uptake protein, putative 0.0024 0.0089 0.054
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1006 0.1031
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0141 0.1499 0.1518
Mycobacterium leprae Conserved hypothetical protein 0.0037 0.0255 0.062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0237 0.2305
Onchocerca volvulus 0.0158 0.1712 0.8851
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0332 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Loa Loa (eye worm) hypothetical protein 0.0067 0.0606 0.0619
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0628 0.695
Schistosoma mansoni zinc finger protein 0.0024 0.0089 0.0049
Brugia malayi hypothetical protein 0.0148 0.1581 0.1686
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0141 0.1499 1
Brugia malayi Dopamine receptor 0.0158 0.1712 0.1826
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0141 0.1499 0.156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0256 0.2527
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus granulosus serotonin receptor 0.0158 0.1712 0.1748
Brugia malayi G-protein coupled receptor 0.0158 0.1712 0.1826
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0231 0.2227
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1728 0.1765
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni sterol O-acyltransferase 1 0.0024 0.0089 0.0049
Trichomonas vaginalis transmembrane protein nessy, putative 0.0024 0.0089 0.0001
Schistosoma mansoni growth hormone secretagogue receptor 0.0158 0.1712 0.1788
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1728 0.1842
Schistosoma mansoni neuropeptide receptor 0.0158 0.1712 0.1788
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0628 0.0545
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0108 0.0086
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0256 0.0273
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0158 0.1712 0.1826
Schistosoma mansoni amine GPCR 0.0158 0.1712 0.1788
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0237 0.2305
Brugia malayi Dopamine receptor protein 2 0.0158 0.1712 0.1826
Brugia malayi Thioredoxin reductase 0.0046 0.0356 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0224 0.0351
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0187 0.0199
Leishmania major glycerol uptake protein, putative 0.0024 0.0089 0.054
Schistosoma mansoni hypothetical protein 0.024 0.2695 0.284
Onchocerca volvulus Neuropeptide F receptor homolog 0.0158 0.1712 0.8851
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0158 0.1712 0.1826
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1203 1
Onchocerca volvulus 0.0053 0.0437 0.19
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0024 0.0089 0.0049
Trichomonas vaginalis porcupine, putative 0.0024 0.0089 0.0001
Echinococcus granulosus G protein coupled receptor 139 0.0158 0.1712 0.1748
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0478 0.5162
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0437 0.0466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0147 0.0151
Loa Loa (eye worm) hhat protein 0.0024 0.0089 0.0066
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0119 0.008
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0628 0.0643
Brugia malayi hypothetical protein 0.0025 0.0108 0.0115
Brugia malayi MBOAT family protein 0.0024 0.0089 0.0095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1063 0.8618
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0628 0.7022
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0628 0.695
Brugia malayi RNA binding protein 0.0135 0.1424 0.1518
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1424 0.1479
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0231 0.0369
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0108 0.0086
Echinococcus multilocularis G protein coupled receptor 139 0.0158 0.1712 0.1638
Echinococcus multilocularis musashi 0.0053 0.0437 0.0352
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.012 0.1252 0.1295
Brugia malayi Dopamine receptor protein 1 0.0158 0.1712 0.1826
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Loa Loa (eye worm) CYP4Cod1 0.0056 0.0478 0.0482
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.1712 0.1748
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0237 0.1333
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.1142 0.1192
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1203 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0231 0.1287
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0231 0.2248
Loa Loa (eye worm) hypothetical protein 0.024 0.2695 0.2852
Brugia malayi intermediate filament protein 0.0053 0.0437 0.0466
Echinococcus granulosus g protein coupled receptor 0.0158 0.1712 0.1748
Echinococcus granulosus fmrfamide receptor 0.0158 0.1712 0.1748
Schistosoma mansoni ap endonuclease 0.0038 0.0256 0.0228
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0024 0.0089 0.0049
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.1424 0.1518
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.011 0.0022
Trichomonas vaginalis glutaminase, putative 0.028 0.3176 0.8007
Leishmania major hypothetical protein, conserved 0.0025 0.0108 0.0765
Brugia malayi cytochrome P450 0.0037 0.0255 0.0271
Echinococcus granulosus neuropeptide FF receptor 2 0.0158 0.1712 0.1748
Echinococcus multilocularis neuropeptide s receptor 0.0619 0.7261 0.7237
Leishmania major cytochrome p450-like protein 0.0037 0.0255 0.251
Echinococcus multilocularis neuropeptide FF receptor 2 0.0158 0.1712 0.1638
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0158 0.1712 0.8851
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0158 0.1712 0.1638
Brugia malayi putative neuropeptide receptor 0.0158 0.1712 0.1826
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0037 0.0255 0.0675
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.1712 0.1748
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0076
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0332 0.0309
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0237 0.0386
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0158 0.1712 0.1638
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.009 0.0885 1
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1712 0.1638
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.072 0.0725
Schistosoma mansoni amine GPCR 0.0158 0.1712 0.1788
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1424 0.1479
Echinococcus granulosus orexin receptor type 2 0.0158 0.1712 0.1748
Onchocerca volvulus 0.0158 0.1712 0.8851
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni ap endonuclease 0.0038 0.0256 0.0228
Schistosoma mansoni glutaminase 0.028 0.3176 0.3355
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0231 0.2248
Schistosoma mansoni biogenic amine receptor 0.0158 0.1712 0.1788
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.1006 0.0988
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0192 0.0049
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0237 0.0386
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0237 0.016
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0795 0.938 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0628 0.067
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1712 0.1638
Trypanosoma brucei cytochrome P450, putative 0.0056 0.0478 0.5275
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0096 0.0102
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0256 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1712 0.1748
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.072 0.0637
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.1712 0.1748
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1728 0.1819
Brugia malayi Cytochrome P450 family protein 0.0118 0.1227 0.1308
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0237 0.2305
Trypanosoma cruzi glycerol uptake protein, putative 0.0024 0.0089 0.054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0158 0.1712 0.1802
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0037 0.0255 0.0675
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.1712 0.1638
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Schistosoma mansoni neuropeptide receptor 0.0158 0.1712 0.1788
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0158 0.1712 0.1638
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0141 0.1499 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0231 0.0369
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.1712 0.1788
Echinococcus granulosus 7TM GPCR rhodopsin 0.0158 0.1712 0.1748
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0332 0.385
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0353 0.406 0.4329
Echinococcus multilocularis neuropeptide receptor A26 0.0619 0.7261 0.7237
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni alpha-1 adrenergic receptor 0.0158 0.1712 0.1788
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.1424 0.1493
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.1712 0.1788
Brugia malayi AKH receptor 0.0158 0.1712 0.1826
Echinococcus multilocularis dro:myosuppressin receptor 0.0158 0.1712 0.1638
Loa Loa (eye worm) hhat protein 0.0024 0.0089 0.0066
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0158 0.1712 0.1788
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1712 0.1788
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0037 0.0255 0.0666
Schistosoma mansoni opsin-like receptor 0.0158 0.1712 0.1788
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.1712 0.1748
Brugia malayi G protein-coupled receptor 0.0158 0.1712 0.1826
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.1712 0.1748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0332 0.0631
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1063 0.8618
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.1006 0.0926
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.1142 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Loa Loa (eye worm) hypothetical protein 0.0148 0.1581 0.1662
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0187 0.19
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Loa Loa (eye worm) inositol-1 0.0036 0.0237 0.0225
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.1712 0.1748
Onchocerca volvulus 0.0158 0.1712 0.8851
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0332 0.3582
Brugia malayi follicle stimulating hormone receptor 0.0402 0.4648 0.4955
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0037 0.0255 0.0675
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0256 0.2527
Brugia malayi larval opioid receptor 0.0158 0.1712 0.1826
Echinococcus granulosus dro:myosuppressin receptor 0.0158 0.1712 0.1748
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0351 0.4033 0.4283
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0402 0.4648 0.4941
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1712 0.1638
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0158 0.1712 0.1638
Mycobacterium tuberculosis Probable reductase 0.0105 0.1063 0.8618
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0037 0.0255 0.0666
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0141 0.1499 0.1423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0089 0.0001
Schistosoma mansoni lamin 0.0053 0.0437 0.0422
Brugia malayi MBOAT family protein 0.0024 0.0089 0.0095
Trichomonas vaginalis chaperonin, putative 0.0024 0.0096 0.0019
Loa Loa (eye worm) hypothetical protein 0.0053 0.0437 0.0439
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0795 0.938 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0108 0.0765
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1006 0.1031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0256 0.2527
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0437 0.0439
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0158 0.1712 0.1788
Brugia malayi isocitrate dehydrogenase 0.0032 0.0187 0.0199
Brugia malayi neuropeptide F receptor 0.0158 0.1712 0.1826
Brugia malayi putative neuropeptide receptor NPR1 0.0158 0.1712 0.1826
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0628 0.695
Brugia malayi Serotonin receptor 0.0158 0.1712 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0197 0.028
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0037 0.0255 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0197 0.028
Schistosoma mansoni hypothetical protein 0.0024 0.0089 0.0049
Toxoplasma gondii dgat2l1-prov protein 0.009 0.0885 0.5782
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0143 0.0153
Entamoeba histolytica hypothetical protein 0.0076 0.072 1
Loa Loa (eye worm) hypothetical protein 0.012 0.1252 0.131
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0237 0.2353
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0158 0.1712 0.1788
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.1923 1
Echinococcus multilocularis lamin dm0 0.0053 0.0437 0.0352
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0256 0.1142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.1712 0.1638
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0187 0.065
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0256 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1712 0.1748
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Loa Loa (eye worm) melatonin receptor type 1A 0.0158 0.1712 0.1802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Entamoeba histolytica hypothetical protein 0.0076 0.072 1
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.002 0.0043 0.0234
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.1712 0.1802
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.1142 0.1134
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1063 0.8618
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0096 0.0019
Brugia malayi hypothetical protein 0.0076 0.072 0.0768
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0231 0.0369
Onchocerca volvulus 0.009 0.0885 0.4341
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0158 0.1712 0.1638
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0037 0.0255 0.0666
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0037 0.0255 0.0666
Echinococcus multilocularis g-protein coupled receptor 0.0158 0.1712 0.1638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0224 0.0351
Schistosoma mansoni hypothetical protein 0.0037 0.0255 0.0226
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0237 0.0386
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0037 0.0255 0.0666
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0066
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0237 0.015
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0037 0.0255 0.0675
Echinococcus multilocularis tar DNA binding protein 0.0135 0.1424 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0255 0.0431
Loa Loa (eye worm) glutathione reductase 0.0046 0.0356 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0224 0.0351
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1063 0.8618
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0187 0.0106
Schistosoma mansoni hypothetical protein 0.0111 0.1142 0.1177
Brugia malayi Tachykinin-like peptides receptor 99D 0.0158 0.1712 0.1826
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.1712 0.1748
Trichomonas vaginalis conserved hypothetical protein 0.0344 0.3944 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0332 0.385
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.1712 0.1748
Loa Loa (eye worm) glutaminase 0.028 0.3176 0.3367
Loa Loa (eye worm) MBOAT family protein 0.0024 0.0089 0.0066
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0231 0.0369
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0037 0.0255 0.0675
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1063 0.8618
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0158 0.1712 0.1788
Schistosoma mansoni hypothetical protein 0.0076 0.072 0.0725
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0141 0.1499 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1712 0.1748
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.012 0.1252 0.1252
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1063 0.8611
Schistosoma mansoni amine GPCR 0.0158 0.1712 0.1788
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0143 0.0124
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0437 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0197 0.028
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0037 0.0255 0.0675
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0096 0.0007
Brugia malayi N-terminal motif family protein 0.0176 0.1923 0.205
Leishmania major trypanothione reductase 0.0046 0.0356 0.3709
Brugia malayi MBOAT family protein 0.0024 0.0089 0.0095
Echinococcus multilocularis lamin 0.0053 0.0437 0.0352
Echinococcus granulosus neuropeptide s receptor 0.0619 0.7261 0.772
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0224 0.215
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0256 0.068
Loa Loa (eye worm) hypothetical protein 0.0795 0.938 1
Brugia malayi ORL1-like opioid receptor 0.0158 0.1712 0.1826
Plasmodium vivax glutathione reductase, putative 0.0046 0.0356 0.1851
Trypanosoma brucei glycerol uptake protein, putative 0.0024 0.0089 0.0761
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1712 0.1748
Schistosoma mansoni biogenic amine receptor 0.0158 0.1712 0.1788
Echinococcus granulosus lamin 0.0053 0.0437 0.0375
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0332 0.0354
Echinococcus multilocularis neuropeptide receptor 0.0158 0.1712 0.1638
Loa Loa (eye worm) diacylglycerol acyltransferase 0.009 0.0885 0.0918
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1712 0.1638
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0256 0.6786
Brugia malayi GNT-I family protein 0.012 0.1252 0.1335
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0054 0.0353
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0158 0.1712 0.1826
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0187 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0116 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0231 0.2227
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0356 0.0351
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0096 0.0056
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0256 0.018
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.2695 0.2873
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0231 0.0246
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.009 0.0885 0.0902
Schistosoma mansoni biogenic amine receptor 0.0158 0.1712 0.1788
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0037 0.0255 0.0675
Brugia malayi Melibiase family protein 0.0067 0.0606 0.0646
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0187 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0119 0.008
Schistosoma mansoni adenoreceptor 0.0158 0.1712 0.1788
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0037 0.0255 0.0666
Mycobacterium ulcerans glutaminase 0.028 0.3176 1
Schistosoma mansoni neuropeptide receptor 0.0158 0.1712 0.1788
Leishmania major glycerol uptake protein, putative 0.0024 0.0089 0.054
Onchocerca volvulus 0.0158 0.1712 0.8851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0158 0.018
Onchocerca volvulus 0.0158 0.1712 0.8851
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0037 0.0255 0.0666
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0037 0.0255 0.0675
Brugia malayi Cytochrome P450 family protein 0.0037 0.0255 0.0271
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.1712 0.1638
Leishmania major hypothetical protein, conserved 0.0024 0.0089 0.054
Loa Loa (eye worm) hypothetical protein 0.0353 0.406 0.4313
Toxoplasma gondii hypothetical protein 0.0024 0.0089 0.0312
Echinococcus granulosus allatostatin A receptor 0.0158 0.1712 0.1748
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0231 0.0369
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0187 0.0099
Echinococcus multilocularis fmrfamide receptor 0.0158 0.1712 0.1638
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Echinococcus granulosus g protein coupled receptor 0.0158 0.1712 0.1748
Echinococcus granulosus alpha 1A adrenergic receptor 0.0158 0.1712 0.1748
Trypanosoma cruzi glycerol uptake protein, putative 0.0024 0.0089 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0119 0.008
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1424 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Echinococcus granulosus peptide allatostatin:somatostatin 0.0158 0.1712 0.1748
Trypanosoma cruzi GUP1, putative 0.0024 0.0089 0.054
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0037 0.0255 0.0666
Echinococcus multilocularis allatostatin A receptor 0.0158 0.1712 0.1638
Loa Loa (eye worm) hypothetical protein 0.0025 0.011 0.0088
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0158 0.1712 0.1638
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0141 0.1499 0.1574
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Brugia malayi Inositol-1 0.0036 0.0237 0.0253
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0158 0.1712 0.1826
Schistosoma mansoni hypothetical protein 0.0158 0.1712 0.1788
Toxoplasma gondii thioredoxin reductase 0.0046 0.0356 0.2145
Echinococcus granulosus g-protein coupled receptor 0.0158 0.1712 0.1748
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0096 0.036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni alpha-glucosidase 0.0138 0.146 0.1518
Echinococcus granulosus neuropeptide receptor 0.0158 0.1712 0.1748
Brugia malayi Serotonin receptor 0.0158 0.1712 0.1826
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1006 0.1031
Brugia malayi sulfakinin receptor protein 0.0158 0.1712 0.1826
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1278 0.3084
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.1712 0.1748
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0158 0.1712 0.1788
Loa Loa (eye worm) TYRA-2 protein 0.0158 0.1712 0.1802
Schistosoma mansoni opsin-like receptor 0.0158 0.1712 0.1788
Brugia malayi glutaminase DH11.1 0.028 0.3176 0.3386
Schistosoma mansoni alpha-glucosidase 0.0138 0.146 0.1518
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.1712 0.1802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Schistosoma mansoni hypothetical protein 0.0111 0.1142 0.1177
Schistosoma mansoni hypothetical protein 0.0511 0.5955 0.6332
Schistosoma mansoni hypothetical protein 0.0111 0.1142 0.1177
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.1712 0.1638
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0037 0.0255 0.251
Entamoeba histolytica hypothetical protein 0.0076 0.072 1
Echinococcus granulosus neuropeptide receptor 0.0158 0.1712 0.1748
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0037 0.0255 0.2685
Leishmania major cytochrome p450-like protein 0.0056 0.0478 0.5162
Brugia malayi Hhat protein 0.0024 0.0089 0.0095
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1006 0.1031
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0037 0.0255 0.0675
Echinococcus granulosus tar DNA binding protein 0.0135 0.1424 0.1437
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1712 0.1788
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.1712 0.1788
Trypanosoma brucei glucosidase, putative 0.0035 0.0231 0.2409
Giardia lamblia GTOR 0.0044 0.0332 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0037 0.0255 0.0666
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1712 0.1748
Echinococcus multilocularis geminin 0.0511 0.5955 0.5919
Loa Loa (eye worm) hypothetical protein 0.0025 0.0108 0.0086
Loa Loa (eye worm) hypothetical protein 0.0158 0.1712 0.1802
Toxoplasma gondii cytochrome p450 superfamily protein 0.0037 0.0255 0.1451
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0037 0.0255 0.0666
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0037 0.0255 0.0666
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0096 0.0007
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0024 0.0089 0.0049
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0256 0.2648
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0037 0.0255 0.0675
Brugia malayi hypothetical protein 0.0158 0.1712 0.1826
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0356 0.0287
Schistosoma mansoni amine GPCR 0.0158 0.1712 0.1788
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0795 0.938 0.9374
Plasmodium falciparum thioredoxin reductase 0.0046 0.0356 0.1851
Leishmania major diacylglycerol acyltransferase, putative 0.009 0.0885 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0231 0.0153
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.1712 0.1638
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0606 0.1341
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0089 0.0001

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 250 ug ml-1 Antibacterial activity against Escherichia coli MTCC 443 assessed as growth inhibition after 24 to 48 hr by NCCLS broth microdilution method ChEMBL. No reference
MIC (functional) = 1000 ug ml-1 Antifungal activity against Candida albicans MTCC 227 assessed as growth inhibition after 24 to 48 hr by NCCLS broth microdilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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