TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.675 | Formula: C21H47N2O2S+
H donors: 1 H acceptors: 2 LogP: 6.77 Rotable bonds: 19
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCCCCCS(=O)(=O)NCCC[N+](CC)(C)C
InChi: 1S/C21H47N2O2S/c1-5-7-8-9-10-11-12-13-14-15-16-17-21-26(24,25)22-19-18-20-23(3,4)6-2/h22H,5-21H2,1-4H3/q+1
InChiKey: WZHHNEPWZHEYMN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0018	0.0047	0.2197
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0075	0.0075
Mycobacterium ulcerans	lipase LipD	0.0042	0.0214	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0698
Echinococcus granulosus	oxysterol binding protein 3	0.0018	0.0047	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.008	0.0325
Trypanosoma cruzi	NIMA-related kinase, putative	0.0022	0.0075	0.1662
Echinococcus granulosus	axis inhibition protein axin	0.0163	0.1072	0.1682
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0018	0.0047	0.0439
Entamoeba histolytica	protein kinase, putative	0.0022	0.0075	0.0698
Brugia malayi	hypothetical protein	0.0163	0.1072	0.1785
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0000039711	0.0000039711
Leishmania major	protein kinase, putative	0.0022	0.0075	0.1662
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0022	0.0075	0.1662
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0022	0.0075	0.1662
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0214	0.0336
Onchocerca volvulus	outspread protein homolog	0.0018	0.0047	0.0834
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0023	0.008	0.1993
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0022	0.0075	0.1662
Echinococcus multilocularis	regulator of G protein signaling 3	0.0163	0.1072	0.1682
Echinococcus granulosus	bloom syndrome protein	0.0023	0.008	0.0126
Brugia malayi	regulator of G-protein signaling rgs-7	0.0163	0.1072	0.1785
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0163	0.1072	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0698
Echinococcus granulosus	DCC interacting protein 13 beta	0.0018	0.0047	0.0074
Brugia malayi	Phospholipase A2 family protein	0.0091	0.0564	0.0939
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.0383	0.0601
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0746	0.5218	0.8187
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0258	0.175	0.175
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.0383	0.0601
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0000039711	0.0000039711
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trichomonas vaginalis	esterase, putative	0.0042	0.0214	0.1632
Entamoeba histolytica	protein kinase, putative	0.0022	0.0075	0.0698
Loa Loa (eye worm)	cytohesin 3	0.0018	0.0047	0.0074
Onchocerca volvulus		0.0018	0.0047	0.0834
Onchocerca volvulus		0.0042	0.0214	0.3798
Schistosoma mansoni	axis inhibition protein axin	0.0163	0.1072	0.1072
Schistosoma mansoni	regulator of G protein signaling	0.0163	0.1072	0.1072
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0125	0.5831
Entamoeba histolytica	hypothetical protein	0.0018	0.0047	0.0439
Echinococcus granulosus	oxysterol binding protein 9	0.0018	0.0047	0.0074
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Echinococcus multilocularis	Pleckstrin y	0.0018	0.0047	0.0074
Leishmania major	serine/threonine-protein kinase a, putative	0.0022	0.0075	0.1662
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0163	0.1072	1
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Brugia malayi	Dynamin	0.0018	0.0047	0.0078
Entamoeba histolytica	p21-activated kinase	0.0022	0.0075	0.0698
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0018	0.0047	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0214	0.5
Echinococcus multilocularis	rac serine:threonine kinase	0.0022	0.0075	0.0117
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus granulosus	Regulator of G protein signaling 20	0.0163	0.1072	0.1682
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Onchocerca volvulus	Phospholipase A2 homolog	0.0091	0.0564	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Entamoeba histolytica	protein kinase, putative	0.0022	0.0075	0.0698
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0214	0.1632
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0214	0.5
Loa Loa (eye worm)	syntrophin-1	0.0018	0.0047	0.0074
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0163	0.1072	0.1682
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.008	0.0134
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0075	0.1662
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0909	0.6374	1
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0018	0.0047	0.0074
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0022	0.0075	0.1662
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.008	0.0325
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0018	0.0047	0.0074
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0125	0.5831
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0018	0.0047	0.0074
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0022	0.0075	0.1662
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0214	0.0336
Brugia malayi	hypothetical protein	0.0029	0.0125	0.0208
Brugia malayi	hypothetical protein	0.0163	0.1072	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0214	0.0336
Brugia malayi	Dynamin	0.0018	0.0047	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0214	0.0336
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0022	0.0075	0.1662
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Entamoeba histolytica	hypothetical protein, conserved	0.0018	0.0047	0.0439
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0214	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.1072	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0125	0.4658
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0018	0.0047	0.0074
Echinococcus multilocularis	oxysterol binding protein 9	0.0018	0.0047	0.0074
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0047	0.0078
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0000039711	0.0000039711
Brugia malayi	MAX-1A	0.0018	0.0047	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.1072	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0857	0.6008	0.9425
Trypanosoma cruzi	Protein kinase B	0.0022	0.0075	0.1662
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0018	0.0047	0.0439
Brugia malayi	Carboxylesterase family protein	0.0066	0.0383	0.0637
Schistosoma mansoni	zinc finger protein	0.0018	0.0047	0.0047
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0022	0.0075	0.1662
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus multilocularis	cytohesin 1	0.0018	0.0047	0.0074
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0022	0.0075	0.1662
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0018	0.0047	0.0078
Brugia malayi	Carboxylesterase family protein	0.0066	0.0383	0.0637
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0214	0.1632
Schistosoma mansoni	hypothetical protein	0.0018	0.0047	0.0047
Echinococcus granulosus	cytohesin 1	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0018	0.0047	0.0074
Loa Loa (eye worm)	PXA domain-containing protein	0.0163	0.1072	0.1682
Schistosoma mansoni	serine/threonine protein kinase	0.0909	0.6374	0.6374
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Entamoeba histolytica	hypothetical protein	0.0163	0.1072	1
Echinococcus granulosus	oxysterol binding protein 1	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Echinococcus multilocularis	regulator of G protein signaling 3	0.0163	0.1072	0.1682
Schistosoma mansoni	regulator of G protein signaling	0.0163	0.1072	0.1072
Brugia malayi	Plekhf2 protein	0.0018	0.0047	0.0078
Entamoeba histolytica	hypothetical protein	0.0018	0.0047	0.0439
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0075	0.0075
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0018	0.0047	0.0439
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0018	0.0047	0.0834
Trypanosoma cruzi	NIMA-related kinase, putative	0.0022	0.0075	0.1662
Echinococcus granulosus	axis inhibition protein axin	0.0163	0.1072	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1072	0.1682
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0694	0.4852	0.7612
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0018	0.0047	0.0047
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0018	0.0047	0.0074
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0018	0.0047	0.0074
Schistosoma mansoni	hypothetical protein	0.0018	0.0047	0.0047
Brugia malayi	regulator of G-protein signaling egl-10	0.0163	0.1072	0.1785
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.008	0.3751
Echinococcus granulosus	acetylcholinesterase	0.0066	0.0383	0.0601
Brugia malayi	beta-lactamase	0.0042	0.0214	0.0357
Loa Loa (eye worm)	acetylcholinesterase 1	0.0066	0.0383	0.0601
Toxoplasma gondii	ABC1 family protein	0.0042	0.0214	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0163	0.1072	0.1682
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0018	0.0047	0.0074
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0018	0.0047	0.2197
Loa Loa (eye worm)	Plekhf2 protein	0.0018	0.0047	0.0074
Entamoeba histolytica	hypothetical protein	0.0018	0.0047	0.0439
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0018	0.0047	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0214	0.0214
Echinococcus granulosus	Pleckstrin y	0.0018	0.0047	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.1072	1
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Schistosoma mansoni	syntrophin	0.0018	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus granulosus	GRB2 associated binding protein 3	0.0018	0.0047	0.0074
Echinococcus multilocularis	axis inhibition protein axin	0.0163	0.1072	0.1682
Schistosoma mansoni	serine/threonine protein kinase	0.0909	0.6374	0.6374
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Onchocerca volvulus		0.0018	0.0047	0.0834
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.1072	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Schistosoma mansoni	hypothetical protein	0.0018	0.0047	0.0047
Echinococcus multilocularis	actin binding protein anillin	0.0018	0.0047	0.0074
Entamoeba histolytica	protein kinase, putative	0.0022	0.0075	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0698
Echinococcus granulosus	calcium dependent secretion activator 1	0.0018	0.0047	0.0074
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0022	0.0075	0.3493
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0694	0.4852	0.7612
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0075	0.1662
Echinococcus granulosus	Oxysterol binding protein 11	0.0018	0.0047	0.0074
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0857	0.6008	1
Brugia malayi	Cadps2 protein	0.0018	0.0047	0.0078
Toxoplasma gondii	Oxysterol-binding protein	0.0018	0.0047	0.2197
Echinococcus granulosus	acetylcholinesterase	0.0066	0.0383	0.0601
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0022	0.0075	0.1662
Toxoplasma gondii	hypothetical protein	0.0018	0.0047	0.2197
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0694	0.4852	0.7612
Onchocerca volvulus		0.0018	0.0047	0.0834
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0125	0.4658
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0214	0.1632
Schistosoma mansoni	axis inhibition protein axin	0.0163	0.1072	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0214	0.0336
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0163	0.1072	0.1785
Brugia malayi	probable spectrin beta chain	0.0018	0.0047	0.0078
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0018	0.0047	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0163	0.1072	0.1682
Echinococcus granulosus	expressed protein	0.0163	0.1072	0.1682
Brugia malayi	hypothetical protein	0.0018	0.0047	0.0078
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.008	0.0325
Echinococcus multilocularis	oxysterol binding protein 1	0.0018	0.0047	0.0074
Echinococcus granulosus	regulator of G protein signaling 7	0.0163	0.1072	0.1682
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0018	0.0047	0.0439
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Leishmania major	hypothetical protein, conserved	0.0029	0.0125	0.4658
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0214	0.5
Schistosoma mansoni	zinc finger protein	0.0018	0.0047	0.0047
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0214	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.182	1
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0023	0.008	0.1993
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0022	0.0075	0.0271
Loa Loa (eye worm)	uncoordinated protein 104	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0564	0.0885
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0023	0.008	0.1993
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0125	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0000039711	0.0000039711
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0163	0.1072	0.1072
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0163	0.1072	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Schistosoma mansoni	regulator of G protein signaling	0.0163	0.1072	0.1072
Toxoplasma gondii	protein kinase domain-containing protein	0.0022	0.0075	0.3493
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.1072	1
Schistosoma mansoni	hypothetical protein	0.0013	0.001	0.001
Brugia malayi	TBC domain containing protein	0.0018	0.0047	0.0078
Brugia malayi	Oxysterol binding protein	0.0018	0.0047	0.0078
Entamoeba histolytica	recQ family helicase, putative	0.0023	0.008	0.075
Echinococcus multilocularis	expressed protein	0.0163	0.1072	0.1682
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Echinococcus granulosus	regulator of G protein signaling 7	0.0163	0.1072	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1072	0.1682
Echinococcus multilocularis	Pleckstrin y	0.0018	0.0047	0.0074
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0018	0.0047	0.0074
Loa Loa (eye worm)	RecQ helicase	0.0023	0.008	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1072	0.1682
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0022	0.0075	0.0117
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0018	0.0047	0.0439
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0023	0.008	0.0126
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0000039711	0.0000039711
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.008	0.0126
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0018	0.0047	0.0047
Echinococcus multilocularis	carboxylesterase 5A	0.0066	0.0383	0.0601
Leishmania major	folate/biopterin transporter, putative	0.0022	0.0075	0.1662
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0018	0.0047	0.0074
Schistosoma mansoni	DNA helicase recq5	0.0023	0.008	0.008
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0022	0.0075	0.0271
Schistosoma mansoni	regulator of G protein signaling	0.0163	0.1072	0.1072
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0909	0.6374	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0022	0.0075	0.3568
Schistosoma mansoni	oxysterol-binding protein 1	0.0018	0.0047	0.0047
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0000039711	0.0000039711
Schistosoma mansoni	serine/threonine protein kinase	0.0857	0.6008	0.6008
Echinococcus granulosus	serine/threonine protein kinase	0.0022	0.0075	0.0117
Echinococcus multilocularis	pdz domain containing protein	0.0018	0.0047	0.0074
Schistosoma mansoni	centaurin alpha	0.0018	0.0047	0.0047
Echinococcus granulosus	pdz domain containing protein	0.0018	0.0047	0.0074
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0000039711	0.0000039711
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0214	0.0336
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0746	0.5218	0.8187
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0125	0.0196
Echinococcus granulosus	Pleckstrin y	0.0018	0.0047	0.0074
Loa Loa (eye worm)	rho-GTPase-activating	0.0018	0.0047	0.0074
Brugia malayi	Syntrophin-1	0.0018	0.0047	0.0078
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.008	0.0134
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Entamoeba histolytica	hypothetical protein	0.0163	0.1072	1
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0018	0.0047	0.0074
Onchocerca volvulus		0.0042	0.0214	0.3798
Echinococcus granulosus	myotubularin protein 13	0.0018	0.0047	0.0074
Schistosoma mansoni	dynamin	0.0018	0.0047	0.0047
Schistosoma mansoni	regulator of G protein signaling	0.0163	0.1072	0.1072
Schistosoma mansoni	hypothetical protein	0.0018	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0125	1
Entamoeba histolytica	protein kinase, putative	0.0022	0.0075	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1072	0.1682
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0000039711	0.0000039711
Brugia malayi	A-kinase anchor protein 10, precursor	0.0163	0.1072	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0214	0.0336
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1072	0.1682
Brugia malayi	Cytohesin 3	0.0018	0.0047	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus multilocularis	beta 1 syntrophin	0.0018	0.0047	0.0074
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0214	0.1632
Trichomonas vaginalis	conserved hypothetical protein	0.0163	0.1072	1
Entamoeba histolytica	PH domain containing protein	0.0018	0.0047	0.0439
Brugia malayi	hypothetical protein	0.0019	0.0051	0.0085
Entamoeba histolytica	hypothetical protein	0.0163	0.1072	1
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0018	0.0047	0.0074
Onchocerca volvulus		0.0018	0.0047	0.0834
Loa Loa (eye worm)	RGS-3 protein	0.0163	0.1072	0.1682
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Schistosoma mansoni	coup transcription factor	0.0012	0.0000039711	0.0000039711
Onchocerca volvulus		0.0018	0.0047	0.0834
Echinococcus granulosus	pleckstrin y domain containing family A	0.0018	0.0047	0.0074
Onchocerca volvulus	Putative zinc finger protein	0.0018	0.0047	0.0834
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0018	0.0047	0.0439
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0023	0.008	0.0126
Entamoeba histolytica	hypothetical protein	0.0022	0.0075	0.0698
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0018	0.0047	0.0439
Loa Loa (eye worm)	PH domain-containing protein	0.0018	0.0047	0.0074
Onchocerca volvulus	Phospholipase A2 homolog	0.0091	0.0564	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.001	0.0016
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0909	0.6374	1
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0018	0.0047	0.0074
Leishmania major	hypothetical protein, conserved	0.0042	0.0214	1
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0047	0.2197
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0698
Entamoeba histolytica	hypothetical protein	0.0018	0.0047	0.0439
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0075	0.0125
Schistosoma mansoni	rho gtpase activating protein	0.0018	0.0047	0.0047
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0023	0.008	0.0126
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0023	0.008	0.0126
Echinococcus granulosus	Pleckstrin y	0.0018	0.0047	0.0074
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0163	0.1072	0.1682
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0000039711	0.0000039711
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0018	0.0047	0.0047
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0125	0.4658
Onchocerca volvulus		0.0018	0.0047	0.0834
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0694	0.4852	0.8076
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0022	0.0075	0.3493
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0018	0.0047	0.0074
Schistosoma mansoni	vav2	0.0018	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus granulosus	regulator of G protein signaling 3	0.0163	0.1072	0.1682
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0214	0.0214
Echinococcus granulosus	regulator of G protein signaling 3	0.0163	0.1072	0.1682
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.008	0.3751
Toxoplasma gondii	hypothetical protein	0.0018	0.0047	0.2197
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0018	0.0047	0.0074
Entamoeba histolytica	PH domain containing protein	0.0018	0.0047	0.0439
Brugia malayi	Oxysterol-binding protein	0.0018	0.0047	0.0078
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0018	0.0047	0.2197
Plasmodium vivax	PH domain containing protein	0.0018	0.0047	0.2197
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0000039711	0.0000039711
Giardia lamblia	Sgs1 DNA helicase, putative	0.0023	0.008	0.5
Entamoeba histolytica	PH domain containing protein	0.0018	0.0047	0.0439
Toxoplasma gondii	AtPH1 family protein	0.0018	0.0047	0.2197
Brugia malayi	PXA domain containing protein	0.0163	0.1072	0.1785
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0023	0.008	0.4278
Brugia malayi	Pleckstrin Homology Domain	0.0018	0.0047	0.0078
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0000039711	0.0000039711
Echinococcus granulosus	beta 1 syntrophin	0.0018	0.0047	0.0074
Entamoeba histolytica	protein kinase, putative	0.0022	0.0075	0.0698
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0023	0.008	0.0126
Brugia malayi	beta-lactamase family protein	0.0042	0.0214	0.0357
Loa Loa (eye worm)	oxysterol binding protein	0.0018	0.0047	0.0074
Brugia malayi	Uncoordinated protein 104	0.0018	0.0047	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0023	0.008	0.0126
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0018	0.0047	0.0047
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0018	0.0047	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0214	0.1632
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0163	0.1072	0.1072
Echinococcus multilocularis	axis inhibition protein axin	0.0163	0.1072	0.1682
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0214	0.0336
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0018	0.0047	0.0834
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0214	1
Trypanosoma brucei	protein kinase, putative	0.0022	0.0075	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0383	0.0601
Brugia malayi	PXA domain containing protein	0.0163	0.1072	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0214	0.0336
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0047	0.0078
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0694	0.4852	0.7612
Echinococcus multilocularis	regulator of G protein signaling 7	0.0163	0.1072	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1072	0.1682
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0018	0.0047	0.0439
Schistosoma mansoni	goodpasture antigen-binding protein	0.0018	0.0047	0.0047
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0214	0.0357
Echinococcus granulosus	dynamin 1	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0564	0.0885
Schistosoma mansoni	z-protein (S1r protein)	0.0163	0.1072	0.1072
Onchocerca volvulus		0.0042	0.0214	0.3798
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0018	0.0047	0.0074
Brugia malayi	PH domain containing protein	0.0018	0.0047	0.0078
Onchocerca volvulus		0.0018	0.0047	0.0834
Echinococcus multilocularis	regulator of G protein signaling	0.0163	0.1072	0.1682
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0022	0.0075	0.1662
Loa Loa (eye worm)	carboxylesterase	0.0066	0.0383	0.0601
Schistosoma mansoni	DNA helicase recq1	0.0023	0.008	0.008
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0698
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.001	0.0016
Onchocerca volvulus	Protein melted homolog	0.0018	0.0047	0.0834
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0066	0.0383	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0383	0.0601
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0163	0.1072	0.1785
Echinococcus multilocularis	dynamin 1	0.0018	0.0047	0.0074
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0022	0.0075	0.1662
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0018	0.0047	0.0074
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0214	0.5
Echinococcus granulosus	Rho GTPase activating protein 24	0.0018	0.0047	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Echinococcus multilocularis	myotubularin protein 13	0.0018	0.0047	0.0074
Schistosoma mansoni	hypothetical protein	0.0018	0.0047	0.0047
Schistosoma mansoni	growth factor receptor-bound protein	0.0018	0.0047	0.0047
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0018	0.0047	0.0074
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0022	0.0075	0.1662
Entamoeba histolytica	hypothetical protein	0.0018	0.0047	0.0439
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0022	0.0075	0.1662
Entamoeba histolytica	protein kinase, putative	0.0022	0.0075	0.0698
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0023	0.008	0.0134
Echinococcus multilocularis	Pleckstrin y	0.0018	0.0047	0.0074
Entamoeba histolytica	hypothetical protein	0.0022	0.0075	0.0698
Leishmania major	protein kinase, putative	0.0022	0.0075	0.1662
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0018	0.0047	0.0074
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0000039711	0.0000039711
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0698
Echinococcus granulosus	carboxylesterase 5A	0.0066	0.0383	0.0601
Schistosoma mansoni	goodpasture antigen-binding protein	0.0018	0.0047	0.0047
Schistosoma mansoni	myotubularin-related protein	0.0018	0.0047	0.0047
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0214	0.5
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0023	0.008	0.4278
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0022	0.0075	0.1662
Schistosoma mansoni	oxysterol-binding protein 1	0.0018	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0047	0.0074
Echinococcus multilocularis	Oxysterol binding protein 11	0.0018	0.0047	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0075	0.0271
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0018	0.0047	0.0078
Brugia malayi	beta-lactamase family protein	0.0042	0.0214	0.0357
Echinococcus multilocularis	oxysterol binding protein 3	0.0018	0.0047	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0214	0.0336
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0018	0.0047	0.0074
Schistosoma mansoni	dynamin	0.0018	0.0047	0.0047

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3041216

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1800641