Detailed information for compound 1842134

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.293 | Formula: C16H14N2O4
  • H donors: 0 H acceptors: 1 LogP: 3.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1oc(=O)n(n1)Cc1ccc(cc1)Oc1ccccc1
  • InChi: 1S/C16H14N2O4/c1-20-15-17-18(16(19)22-15)11-12-7-9-14(10-8-12)21-13-5-3-2-4-6-13/h2-10H,11H2,1H3
  • InChiKey: SANFQHYDLLLXLM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoglyceride lipase Starlite/ChEMBL References
Homo sapiens fatty acid amide hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major hypothetical protein, conserved fatty acid amide hydrolase 579 aa 471 aa 26.5 %
Plasmodium falciparum esterase, putative monoglyceride lipase 303 aa 254 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0037 0.0094
Trypanosoma brucei trypanothione reductase 0.0032 0.0093 0.0234
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0035 0.0109 0.0275
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0019 0.0033 0.8586
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0014 0.0008 0.0021
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Brugia malayi hypothetical protein 0.0014 0.0008 0.0021
Echinococcus multilocularis ubiquitin specific protease 41 0.002 0.0038 0.0038
Brugia malayi glutathione reductase 0.0032 0.0093 0.0234
Echinococcus granulosus expressed conserved protein 0.0137 0.0579 0.0604
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0108 0.0445 0.1123
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0103 0.0419 0.1058
Brugia malayi Bromodomain containing protein 0.0111 0.046 0.1159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0021
Schistosoma mansoni bromodomain containing protein 0.0094 0.0379 0.0396
Schistosoma mansoni inositol monophosphatase 0.0023 0.0052 0.0054
Schistosoma mansoni inositol monophosphatase 0.0023 0.0052 0.0054
Trichomonas vaginalis esterase, putative 0.0072 0.0277 0.0698
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0848 0.2139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Schistosoma mansoni hypothetical protein 0.0043 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0181
Echinococcus granulosus neuropeptide receptor A26 0.0291 0.129 0.1345
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0033 0.01 0.0105
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0014 0.0008 0.0021
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0094 0.0238
Schistosoma mansoni intermediate filament proteins 0.0022 0.0048 0.005
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0037 0.0117 0.0296
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0037 0.0039
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0114 0.2579
Loa Loa (eye worm) amidase 0.0015 0.0015 0.0037
Leishmania major DNA polymerase eta, putative 0.0017 0.0024 0.0061
Loa Loa (eye worm) glutathione reductase 0.0032 0.0093 0.0234
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0062 0.0234 0.0244
Echinococcus multilocularis sterol regulatory element binding protein 0.0063 0.0235 0.0235
Onchocerca volvulus 0.0022 0.0048 0.0738
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0122
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0015 0.0346
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0016 0.0019 0.0246
Onchocerca volvulus 0.0022 0.0048 0.0738
Echinococcus granulosus cathepsin l1 0.0022 0.0048 0.005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0037 0.0094
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0048 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0277 0.0277
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0062 0.0234 0.0244
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0014 0.0008 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0277 0.0698
Entamoeba histolytica cysteine protease, putative 0.0022 0.0048 0.0122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0122
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0103 0.0419 0.1058
Loa Loa (eye worm) hypothetical protein 0.0105 0.043 0.1085
Echinococcus granulosus lamin 0.0022 0.0048 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0019 0.0047
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.006 0.0225 0.0235
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0145 0.0365
Entamoeba histolytica acyl-coA synthetase, putative 0.0036 0.0114 0.0289
Brugia malayi PHD-finger family protein 0.0037 0.0117 0.0294
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0871 0.3966 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0103 0.0419 0.8358
Trichomonas vaginalis replication factor C large subunit, putative 0.0014 0.0008 0.0021
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0052 0.0131
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0067 0.0256 0.1244
Leishmania major phosphopantetheinyl transferase-like protein 0.0016 0.0019 0.0047
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0015 0.0037
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0871 0.3966 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0025 0.0063 0.0065
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0122
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.027 0.027
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0848 0.2139
Brugia malayi Cathepsin L-like cysteine proteinase 0.0015 0.0015 0.0037
Brugia malayi hypothetical protein 0.0014 0.0008 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0037 0.0094
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0037 0.0039
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0072 0.1432
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0037 0.0039
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0056 0.0202 0.051
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0048 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0181
Brugia malayi beta-lactamase 0.0072 0.0277 0.0698
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0871 0.3966 0.3966
Onchocerca volvulus 0.0036 0.0114 0.2002
Schistosoma mansoni aldehyde dehydrogenase 0.0075 0.0291 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0277 0.0698
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.027 0.0682
Loa Loa (eye worm) hypothetical protein 0.0063 0.0238 0.06
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0023 0.0052 0.0131
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0027 0.0072 0.1543
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0538 0.1357
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.002 0.0038 0.0096
Echinococcus granulosus microtubule associated protein 2 0.2089 0.9591 1
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0848 0.2139
Leishmania major 4-coumarate:coa ligase-like protein 0.0036 0.0114 0.0289
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0037 0.0039
Brugia malayi Pax transcription activation domain interacting protein 0.0014 0.0008 0.0021
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0048 0.0122
Schistosoma mansoni hypothetical protein 0.006 0.0225 0.0235
Mycobacterium ulcerans aldehyde dehydrogenase 0.0075 0.0291 0.5803
Leishmania major mitochondrial DNA polymerase beta 0.0229 0.1001 0.2525
Brugia malayi Bromodomain containing protein 0.0057 0.0208 0.0525
Mycobacterium tuberculosis Conserved protein 0.0072 0.0277 0.1344
Mycobacterium ulcerans hypothetical protein 0.0072 0.0277 0.5517
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0037 0.0039
Plasmodium vivax vivapain-2 0.0022 0.0048 0.0122
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0103 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0138 0.0348
Echinococcus multilocularis thioredoxin glutathione reductase 0.0032 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0229 0.1001 0.2525
Echinococcus multilocularis muscleblind protein 0.0105 0.043 0.043
Schistosoma mansoni amidase 0.0123 0.0514 0.0536
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0871 0.3966 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0871 0.3966 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0037 0.0039
Loa Loa (eye worm) hypothetical protein 0.0108 0.0446 0.1125
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0063 0.0065
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0335 0.0844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0538 0.1357
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0538 0.1357
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0229 0.1001 0.2525
Mycobacterium leprae Probable lipase LipE 0.0072 0.0277 0.6532
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0033 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0277 0.0698
Brugia malayi topoisomerase 0.0014 0.0008 0.0021
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0015 0.0015 0.0015
Echinococcus multilocularis expressed conserved protein 0.0137 0.0579 0.0579
Plasmodium vivax PST-A protein 0.0084 0.0335 0.0844
Schistosoma mansoni transcription factor LCR-F1 0.0048 0.0166 0.0173
Leishmania major DNA polymerase eta, putative 0.0024 0.0057 0.0145
Leishmania major 4-coumarate:coa ligase-like protein 0.0036 0.0114 0.0289
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0698
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0335 0.0844
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0075 0.0291 0.0291
Echinococcus granulosus lamin dm0 0.0022 0.0048 0.005
Schistosoma mansoni peptidase Clp (S14 family) 0.0103 0.0419 0.0437
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0019 0.0047
Onchocerca volvulus 0.0022 0.0048 0.0754
Schistosoma mansoni survival motor neuron protein 0.0066 0.0251 0.0262
Trypanosoma cruzi amidase, putative 0.0015 0.0015 0.0037
Trypanosoma cruzi FHA domain containing protein, putative 0.0014 0.0008 0.0021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0277 0.1344
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0871 0.3966 1
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0122
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0014 0.0008 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0048 0.0166 0.0173
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0037 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0037 0.0094
Echinococcus granulosus survival motor neuron protein 1 0.0324 0.1442 0.1504
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0277 0.1344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0089 0.0355 0.037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0037 0.0039
Giardia lamblia Replication factor C, subunit 1 0.0014 0.0008 0.222
Schistosoma mansoni importin beta-1 0.0025 0.0064 0.0066
Loa Loa (eye worm) transcription factor SMAD2 0.0073 0.0282 0.071
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0698
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0019 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0235 0.0593
Schistosoma mansoni hypothetical protein 0.0415 0.1862 0.1941
Leishmania major hypothetical protein, conserved 0.0023 0.0051 0.0128
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0021 0.0041 0.0199
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.027 0.0682
Loa Loa (eye worm) hypothetical protein 0.0063 0.0235 0.0593
Schistosoma mansoni topbp1 0.0014 0.0008 0.0009
Brugia malayi Probable ClpP-like protease 0.0103 0.0419 0.1058
Entamoeba histolytica hypothetical protein 0.0048 0.0166 0.0419
Plasmodium falciparum replication factor C subunit 1, putative 0.0014 0.0008 0.0021
Echinococcus granulosus fatty acid amide hydrolase 1 0.0015 0.0015 0.0015
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0277 0.5517
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0033 0.01 0.01
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.0336 0.0847
Echinococcus granulosus fetal alzheimer antigen falz 0.0033 0.01 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0037 0.0039
Schistosoma mansoni zinc finger protein 0.0029 0.008 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0075 0.0291 0.5803
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0538 0.1357
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0052 0.0131
Loa Loa (eye worm) amidase 0.0015 0.0015 0.0037
Schistosoma mansoni microtubule-associated protein tau 0.2089 0.9591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Plasmodium vivax glutathione reductase, putative 0.0032 0.0093 0.0234
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0015 0.0015 0.007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0037 0.0037
Onchocerca volvulus 0.0022 0.0048 0.0754
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0848 0.2139
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0114 0.228
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0335 0.0844
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0122
Schistosoma mansoni hypothetical protein 0.0043 0.0145 0.0151
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.002 0.0038 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0086 0.0086
Echinococcus multilocularis nibrin 0.0014 0.0008 0.0008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0036 0.0114 0.228
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0335 0.0844
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0048 0.012
Loa Loa (eye worm) thioredoxin reductase 0.0032 0.0093 0.0234
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0048 0.005
Plasmodium vivax vivapain-2 0.0022 0.0048 0.0122
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0048 0.0122
Mycobacterium tuberculosis Possible lysophospholipase 0.0084 0.0335 0.1625
Schistosoma mansoni methyl-cpg binding protein mbd 0.0025 0.0063 0.0065
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0146 0.062 0.1564
Echinococcus granulosus protein tyrosine kinase 0.0168 0.0721 0.0752
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.0336 0.0847
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0115
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0014 0.0008 0.0021
Schistosoma mansoni thyroid hormone receptor 0.002 0.0037 0.0039
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0015 0.0289
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0016 0.0019 0.0369
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0048 0.0122
Schistosoma mansoni topbp1 0.0014 0.0008 0.0009
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0122
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0871 0.3966 1
Leishmania major cathepsin L-like protease 0.0085 0.0336 0.0847
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.002 0.0038 0.0096
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0698
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0015 0.0015 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0037 0.0094
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0087 0.022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0065 0.0315
Leishmania major importin beta-1 subunit, putative 0.0021 0.0041 0.0104
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0035 0.0109 0.0275
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.027 0.0682
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0871 0.3966 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0065 0.0315
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0514 0.0536
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0019 0.0033 0.0082
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0122
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0052 0.0131
Echinococcus multilocularis lamin 0.0022 0.0048 0.0048
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0015 0.0015 0.007
Plasmodium vivax ataxin-2 like protein, putative 0.0017 0.0023 0.0059
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0048 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0093 0.0376 0.0947
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0021
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0033 0.0033
Echinococcus granulosus GPCR family 2 0.0043 0.0145 0.0151
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0103 0.0419 0.1058
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0016 0.0019 0.0441
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0514 0.0514
Mycobacterium ulcerans amidase 0.0015 0.0015 0.0289
Mycobacterium ulcerans hypothetical protein 0.0084 0.0335 0.6672
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.002 0.0038 0.0096
Echinococcus granulosus peptidase Clp S14 family 0.0067 0.0256 0.0267
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0021 0.0041 0.0792
Echinococcus granulosus muscleblind protein 0.0105 0.043 0.0449
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0075 0.0291 0.1414
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0056 0.0202 0.051
Trypanosoma cruzi monoglyceride lipase, putative 0.0084 0.0335 0.0844
Mycobacterium ulcerans peptide amidase, GatA 0.0015 0.0015 0.0289
Toxoplasma gondii aldehyde dehydrogenase 0.0075 0.0291 0.0734
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0048 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0277 0.0698
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.002 0.0038 0.004
Brugia malayi beta-lactamase family protein 0.0072 0.0277 0.0698
Trypanosoma cruzi amidase, putative 0.0015 0.0015 0.0037
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.091 0.0949
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.0514 0.0536
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0037
Echinococcus multilocularis GPCR, family 2 0.0043 0.0145 0.0145
Mycobacterium ulcerans hypothetical protein 0.0036 0.0114 0.228
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0073 0.0281 0.6625
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0103 0.0419 0.1058
Echinococcus granulosus L aminoadipate semialdehyde 0.0056 0.0204 0.0213
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0015 0.0015
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.027 0.0682
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0103 0.0419 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0081 0.0318 0.1544
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0067 0.0169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Brugia malayi amidase 0.0123 0.0514 0.1297
Brugia malayi steroid hormone receptor 0.002 0.0037 0.0094
Brugia malayi CHE-14 protein 0.0063 0.0235 0.0593
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0871 0.3966 1
Brugia malayi hypothetical protein 0.0037 0.0117 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0538 0.1357
Brugia malayi Cathepsin L-like precursor 0.0015 0.0015 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0114 0.0289
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0056 0.0204 0.0514
Onchocerca volvulus Glucosylceramidase homolog 0.0128 0.0538 1
Schistosoma mansoni hypothetical protein 0.0415 0.1862 0.1941
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0514 0.0536
Toxoplasma gondii ATPase, AAA family protein 0.0014 0.0008 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0017 0.0023 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0698
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.0336 0.0847
Brugia malayi Melibiase family protein 0.0042 0.0138 0.0348
Trypanosoma brucei ISWI complex protein 0.0023 0.0051 0.0128
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0073 0.0281 0.1362
Toxoplasma gondii hypothetical protein 0.0035 0.0109 0.0275
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.0335 0.0844
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0277 0.0289
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.0502 0.2436
Schistosoma mansoni DNA polymerase eta 0.0024 0.0057 0.006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0072 0.0349
Entamoeba histolytica acyl-CoA synthetase, putative 0.0036 0.0114 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0015 0.0037
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0015 0.0015 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0848 0.2139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0037
Echinococcus multilocularis neuropeptide s receptor 0.0291 0.129 0.129
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0048 0.0122
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.027 0.0682
Brugia malayi hypothetical protein 0.0026 0.0066 0.0167
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0048 0.0122
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0033 0.0034
Trichomonas vaginalis inositol monophosphatase, putative 0.0023 0.0052 0.0131
Mycobacterium ulcerans amidase 0.0015 0.0015 0.0289
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0037 0.0094
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0062 0.0234 0.0244
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0062 0.0234 0.0244
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.002 0.0038 0.0096
Echinococcus multilocularis survival motor neuron protein 1 0.0324 0.1442 0.1442
Leishmania major hypothetical protein, conserved 0.0017 0.0023 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0538 0.1357
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.003 0.0086 0.0218
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0048 0.012
Schistosoma mansoni lamin 0.0022 0.0048 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0037 0.0094
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0335 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0021
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0016 0.0019 0.0047
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0037 0.0039
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0871 0.3966 0.4136
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0033 0.0082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Onchocerca volvulus 0.0072 0.0277 0.5069
Brugia malayi intermediate filament protein 0.0022 0.0048 0.012
Onchocerca volvulus 0.0015 0.0015 0.0115
Loa Loa (eye worm) fibroinase 0.0022 0.0048 0.0122
Toxoplasma gondii hypothetical protein 0.0037 0.0116 0.0293
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0037 0.0037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0036 0.0114 0.2579
Brugia malayi Amidase family protein 0.0015 0.0015 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Entamoeba histolytica hypothetical protein 0.0048 0.0166 0.0419
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0165
Onchocerca volvulus 0.0022 0.0048 0.0754
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0056 0.0204 0.0213
Loa Loa (eye worm) hypothetical protein 0.0108 0.0446 0.1125
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0114 0.228
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0048 0.012
Brugia malayi Niemann-Pick C1 protein precursor 0.0146 0.062 0.1564
Echinococcus granulosus thioredoxin glutathione reductase 0.0032 0.0093 0.0097
Echinococcus multilocularis geminin 0.0415 0.1862 0.1862
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0081 0.0318 0.7534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0037 0.0094
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0103 0.0419 1
Echinococcus granulosus geminin 0.0415 0.1862 0.1941
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0062 0.0234 0.0234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0136 0.0575 0.1449
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0025 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0181
Echinococcus granulosus FTZ F1 alpha 0.002 0.0037 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.012
Entamoeba histolytica hypothetical protein 0.0016 0.0019 0.0047
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0026 0.0066 0.0167
Echinococcus granulosus snurportin 1 0.0272 0.1203 0.1254
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.002 0.0038 0.004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0037 0.0094
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0037 0.0544
Leishmania major hypothetical protein, conserved 0.0015 0.0015 0.0037
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0026 0.0066 0.0167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0036 0.0114 0.0289
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0103 0.0419 0.0419
Schistosoma mansoni hypothetical protein 0.0043 0.0145 0.0151
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.062 0.0647
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0089 0.0355 0.0355
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0023 0.0059
Schistosoma mansoni hypothetical protein 0.0023 0.0051 0.0053
Plasmodium falciparum importin beta, putative 0.0025 0.0064 0.016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0277 0.5517
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0871 0.3966 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0 0.0001
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0871 0.3966 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Plasmodium vivax thioredoxin reductase, putative 0.0032 0.0093 0.0234
Trypanosoma cruzi DNA polymerase eta, putative 0.0024 0.0057 0.0145
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0033 0.0082
Onchocerca volvulus Huntingtin homolog 0.0108 0.0446 0.8262
Loa Loa (eye worm) beta-lactamase 0.0072 0.0277 0.0698
Echinococcus granulosus importin subunit beta 1 0.0025 0.0064 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0086 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0145
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0042 0.0138 0.0144
Schistosoma mansoni DNA ligase IV 0.0014 0.0008 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0024 0.0057 0.0145
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0015 0.0015
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.0335 0.0844
Echinococcus multilocularis cysteine protease 0.0022 0.0048 0.0048
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0015 0.0015 0.007
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0037 0.0094
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0136 0.0575 0.1449
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0042 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0165
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0871 0.3966 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0014 0.0008 0.0021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0272 0.1203 0.3032
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0062 0.0234 0.0244
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0195 0.0848 0.2139
Echinococcus multilocularis protein patched 0.0063 0.0235 0.0235
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0053 0.0192 0.02
Mycobacterium ulcerans lipase LipD 0.0072 0.0277 0.5517
Mycobacterium tuberculosis Conserved protein 0.0072 0.0277 0.1344
Echinococcus multilocularis microtubule associated protein 2 0.2089 0.9591 0.9591
Echinococcus granulosus neuropeptide s receptor 0.0291 0.129 0.1345
Onchocerca volvulus 0.002 0.0037 0.0544
Echinococcus granulosus sterol regulatory element binding protein 0.0063 0.0235 0.0245
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0015 0.0015 0.007
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.062 0.062
Echinococcus multilocularis musashi 0.0022 0.0048 0.0048
Brugia malayi hypothetical protein 0.0026 0.0065 0.0165
Onchocerca volvulus Huntingtin homolog 0.0108 0.0446 0.8262
Onchocerca volvulus 0.0022 0.0048 0.0754
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0052 0.0131
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0048 0.0754
Plasmodium vivax replication factor C subunit 1, putative 0.0014 0.0008 0.0021
Echinococcus multilocularis dna polymerase eta 0.0024 0.0057 0.0057
Echinococcus multilocularis lamin dm0 0.0022 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0043 0.0145 0.0151
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0015 0.0015 0.0015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0277 0.1344
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0289
Schistosoma mansoni neuropeptide receptor 0.0108 0.0443 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.003 0.0086 0.009
Schistosoma mansoni ran 0.0019 0.0033 0.0034
Trypanosoma cruzi cruzipain precursor, putative 0.0085 0.0336 0.0847
Echinococcus granulosus intermediate filament protein 0.0022 0.0048 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0065 0.0315
Loa Loa (eye worm) hypothetical protein 0.0146 0.062 0.1564
Brugia malayi hypothetical protein 0.0017 0.0023 0.0059
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0335 0.0844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0037 0.0094
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0037 0.0094
Toxoplasma gondii cathepsin CPL 0.0022 0.0048 0.0122
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0122
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.002 0.0038 0.0038
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0033 0.0082
Loa Loa (eye worm) hypothetical protein 0.0103 0.0419 0.1058
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0148 0.0631 0.0658
Schistosoma mansoni tyrosine kinase 0.0168 0.0721 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0038 0.0096
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0073 0.0281 0.1362
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0036 0.0114 0.228
Brugia malayi cathepsin L-like precursor 0.0015 0.0015 0.0037
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.002 0.0038 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Brugia malayi hypothetical protein 0.0048 0.0166 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.0021
Trypanosoma cruzi ISWI complex protein 0.0023 0.0051 0.0128
Onchocerca volvulus 0.0016 0.0018 0.0188
Loa Loa (eye worm) hypothetical protein 0.0105 0.043 0.1085
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0048 0.0754
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0145 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0037 0.0094
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0871 0.3966 0.4136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0036 0.0114 0.0555
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0181
Brugia malayi putative amidase 0.0015 0.0015 0.0037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0277 0.0698
Echinococcus multilocularis neuropeptide receptor 0.0108 0.0443 0.0443
Onchocerca volvulus 0.0022 0.0048 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0048 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0037 0.0037
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.002 0.0038 0.0096
Entamoeba histolytica Ran family GTPase 0.0019 0.0033 0.0082
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0081 0.0318 0.1544
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0062 0.0234 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Loa Loa (eye worm) hypothetical protein 0.006 0.0225 0.0567
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0014 0.0008 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.057 0.1437
Mycobacterium tuberculosis Probable dehydrogenase 0.0073 0.0281 0.1362
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0277 0.1344
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0037 0.0094
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0037 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0037 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0145 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0037 0.0094
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0041 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0075 0.0291 0.5803
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0075 0.0291 0.0304
Echinococcus multilocularis zinc finger protein 0.0029 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0289
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0035 0.0109 0.2601
Loa Loa (eye worm) hypothetical protein 0.0025 0.0063 0.0158
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0871 0.3966 1
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0122
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0037 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0037
Echinococcus granulosus nibrin 0.0014 0.0008 0.0009
Onchocerca volvulus 0.0022 0.0048 0.0754
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.0445 0.1123
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077 0.0302 0.0762
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0064 0.016
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0277 0.0698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0037 0.0094
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0032 0.0094 0.0238
Plasmodium falciparum glutathione reductase 0.0032 0.0093 0.0234
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0019 0.0033 0.0082
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0277 0.0289
Loa Loa (eye worm) inositol-1 0.0023 0.0052 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.057 0.1437
Leishmania major cathepsin L-like protease 0.0085 0.0336 0.0847
Onchocerca volvulus Protein cycle homolog 0.0026 0.0066 0.109
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0075 0.0291 0.0734
Leishmania major monoglyceride lipase, putative 0.0084 0.0335 0.0844
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.206 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0023 0.0052 0.0131
Entamoeba histolytica hypothetical protein 0.0014 0.0008 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0114 0.228
Schistosoma mansoni fatty-acid amide hydrolase 0.0015 0.0015 0.0015
Echinococcus granulosus neuropeptide receptor 0.0108 0.0443 0.0462
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0037 0.0037
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0042 0.0138 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0037 0.0094
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0277 0.1344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0277 0.0289
Toxoplasma gondii ABC1 family protein 0.0072 0.0277 0.0698
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.0318 0.1544
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.0021
Onchocerca volvulus Cathepsin F homolog 0.0022 0.0048 0.0754
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0048 0.0122
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0023 0.0052 0.1038
Trypanosoma cruzi ISWI complex protein 0.0023 0.0051 0.0128
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0023 0.0052 0.1242
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0277 0.0698
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.003 0.0086 0.0218
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0037 0.0037
Brugia malayi Cathepsin L-like precursor 0.0015 0.0015 0.0037
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0015 0.0015 0.007
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0016 0.0019 0.0047
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0253 0.0637
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.016
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0037 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0048 0.005
Mycobacterium ulcerans hypothetical protein 0.012 0.0502 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0117 0.0294
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0016 0.0019 0.0369
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0014 0.0008 0.0021
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.091 0.091
Loa Loa (eye worm) ctsf protein 0.0022 0.0048 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Onchocerca volvulus 0.0056 0.0204 0.3692
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0114 0.0289
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0052 0.0131
Loa Loa (eye worm) cysteine protease 0.0022 0.0048 0.0122
Brugia malayi nuclear hormone receptor 0.002 0.0037 0.0094
Toxoplasma gondii melibiase subfamily protein 0.0062 0.0234 0.059
Echinococcus multilocularis muscleblind protein 1 0.0105 0.043 0.043
Schistosoma mansoni chromosome transmission fidelity factor 0.0014 0.0008 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0145 0.0151
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0037 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0073 0.0282 0.071
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0067 0.0256 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0048 0.0122
Brugia malayi Muscleblind-like protein 0.0105 0.043 0.1085
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0015 0.0015 0.0346
Brugia malayi RNA, U transporter 1 0.0072 0.0281 0.0708
Brugia malayi nuclear receptor NHR-88 0.002 0.0037 0.0094
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.027 0.0682
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.002 0.0038 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0019 0.0047
Schistosoma mansoni zinc finger protein 0.0023 0.0051 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Leishmania major hypothetical protein, conserved 0.0072 0.0277 0.0698
Schistosoma mansoni lamin 0.0022 0.0048 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0093 0.0234
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0073 0.0281 0.1362
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0103 0.0419 0.0437
Entamoeba histolytica hypothetical protein 0.0021 0.0041 0.0104
Plasmodium falciparum esterase, putative 0.0084 0.0335 0.0844
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0277 0.1344
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0195 0.0848 0.2139
Onchocerca volvulus 0.0022 0.0048 0.0754
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0037 0.0094
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0277 0.1344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0086 0.009
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.002 0.0038 0.0038
Brugia malayi Amidase family protein 0.0015 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0165
Mycobacterium ulcerans amidase 0.0015 0.0015 0.0289
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0134 0.014
Echinococcus granulosus zinc finger protein 0.0029 0.008 0.0083
Schistosoma mansoni hypothetical protein 0.0093 0.0376 0.0392
Echinococcus multilocularis replication factor c subunit 1 0.0014 0.0008 0.0008
Trichomonas vaginalis ran, putative 0.0019 0.0033 0.0082
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0037 0.0039
Brugia malayi hypothetical protein 0.0108 0.0446 0.1125
Mycobacterium tuberculosis Probable reductase 0.0073 0.0281 0.1362
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0033 0.0082
Loa Loa (eye worm) hypothetical protein 0.0324 0.1442 0.3636
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0014 0.0008 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.0021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0041 0.0104
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0084 0.0335 0.0844
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0025 0.0063 0.0063
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0084 0.0335 0.0844
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0048 0.0122
Schistosoma mansoni hypothetical protein 0.006 0.0225 0.0235
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0037 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0036 0.0114 0.0289
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0145 0.0151
Leishmania major trypanothione reductase 0.0032 0.0093 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0032 0.0094 0.0238
Mycobacterium ulcerans amidase 0.0015 0.0015 0.0289
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.002 0.0038 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0021
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0094 0.0238
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.0445 0.1123
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0165
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0059
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0698
Plasmodium falciparum acyl-CoA synthetase 0.0027 0.0072 0.0181
Onchocerca volvulus 0.0072 0.0277 0.5069
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0145 0.0365
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0094
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0053 0.0192 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Echinococcus granulosus cathepsin l1 0.0015 0.0015 0.0015
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0335 0.0844
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0016 0.0019 0.009
Mycobacterium ulcerans lysophospholipase 0.0084 0.0335 0.6672
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0033 0.0082
Echinococcus granulosus inositol monophosphatase 1 0.0023 0.0052 0.0054
Plasmodium vivax acyl-CoA synthetase, putative 0.0027 0.0072 0.0181
Echinococcus multilocularis neuropeptide receptor A26 0.0291 0.129 0.129
Echinococcus granulosus aryl hydrocarbon receptor 0.0037 0.0117 0.0122
Loa Loa (eye worm) hypothetical protein 0.0077 0.03 0.0758
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0086 0.009
Onchocerca volvulus 0.0066 0.0251 0.4582
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0103 0.0419 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0134 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Brugia malayi MH2 domain containing protein 0.0073 0.0282 0.071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0181
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0067 0.0256 0.6031
Schistosoma mansoni hypothetical protein 0.0031 0.0087 0.0091
Echinococcus multilocularis inositol monophosphatase 1 0.0023 0.0052 0.0052
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0041 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0065 0.0315
Plasmodium vivax importin-beta 2, putative 0.0025 0.0064 0.016
Onchocerca volvulus 0.0037 0.0117 0.2041
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0063 0.0065
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0073 0.0281 0.1362
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0015 0.0015 0.0148
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0084 0.0335 0.0844
Echinococcus multilocularis protein dispatched 1 0.0072 0.0276 0.0276
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0026 0.0066 0.0069
Mycobacterium tuberculosis Conserved protein 0.0072 0.0277 0.1344
Loa Loa (eye worm) hypothetical protein 0.0043 0.0145 0.0365
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0015 0.0015 0.0015
Echinococcus multilocularis L aminoadipate semialdehyde 0.0056 0.0204 0.0204
Schistosoma mansoni coup transcription factor 0.002 0.0037 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0048 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0289
Schistosoma mansoni hypothetical protein 0.006 0.0225 0.0235
Mycobacterium ulcerans beta-lactamase 0.0072 0.0277 0.5517
Loa Loa (eye worm) hypothetical protein 0.0057 0.0209 0.0526
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.0056 0.0202 0.051
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0514 0.0514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.003 0.0086 0.009
Plasmodium falciparum thioredoxin reductase 0.0032 0.0093 0.0234
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0024 0.0061
Loa Loa (eye worm) TK/FAK protein kinase 0.017 0.073 0.1842
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0145 0.0365
Echinococcus granulosus dna polymerase eta 0.0024 0.0057 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0277 0.0698
Brugia malayi Thioredoxin reductase 0.0032 0.0093 0.0234
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0103 0.0419 0.8358
Schistosoma mansoni hypothetical protein 0.0272 0.1203 0.1254
Brugia malayi Protein kinase domain containing protein 0.017 0.073 0.1842
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0063 0.0235 0.0593
Brugia malayi Inositol-1 0.0023 0.0052 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0015 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0037 0.0039
Leishmania major GTP-binding protein, putative 0.0019 0.0033 0.0082
Echinococcus granulosus ubiquitin specific protease 41 0.002 0.0038 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0538 0.1357
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0103 0.0419 1
Brugia malayi beta-lactamase family protein 0.0072 0.0277 0.0698
Echinococcus multilocularis G protein coupled receptor 139 0.0108 0.0443 0.0443
Echinococcus multilocularis cysteine protease 0.0022 0.0048 0.0048
Echinococcus multilocularis snurportin 1 0.0272 0.1203 0.1203
Brugia malayi latrophilin 2 splice variant baaae 0.0093 0.0376 0.0947
Echinococcus granulosus replication factor c subunit 1 0.0014 0.0008 0.0009
Trypanosoma brucei PAB1-binding protein , putative 0.0017 0.0023 0.0059
Echinococcus multilocularis peptidase Clp (S14 family) 0.0067 0.0256 0.0256
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0066 0.0251 0.0633
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.002 0.0038 0.0096
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0114 0.228
Loa Loa (eye worm) hypothetical protein 0.0136 0.0575 0.1449
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.002 0.0038 0.0096
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0277 0.6532
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0064 0.0064
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0014 0.0008 0.0021
Treponema pallidum DNA ligase (lig) 0.0014 0.0008 0.0201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0037 0.0094
Echinococcus multilocularis protein tyrosine kinase 0.0168 0.0721 0.0721
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0335 0.0844
Schistosoma mansoni hypothetical protein 0.0066 0.0251 0.0262
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0021
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0122
Leishmania major cathepsin L-like protease 0.0085 0.0336 0.0847
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0848 0.2139
Brugia malayi Importin beta-1 subunit 0.0025 0.0064 0.016
Schistosoma mansoni hypothetical protein 0.0048 0.0166 0.0173
Toxoplasma gondii thioredoxin reductase 0.0032 0.0093 0.0234
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0037 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0025 0.0063 0.0065
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0015 0.0015 0.0037
Mycobacterium ulcerans amidase 0.0015 0.0015 0.0289
Brugia malayi hypothetical protein 0.0324 0.1442 0.3636
Schistosoma mansoni patched 1 0.0063 0.0235 0.0245
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0277 0.0698
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0023 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0064 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0136 0.0575 0.1449
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0064 0.016
Loa Loa (eye worm) hypothetical protein 0.0123 0.0514 0.1297
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0023 0.0059
Schistosoma mansoni nuclear hormone receptor 0.002 0.0037 0.0039
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0015 0.0015 0.0148
Plasmodium falciparum lysophospholipase, putative 0.0084 0.0335 0.0844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.027 0.0282
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0032 0.0093 0.045
Entamoeba histolytica hypothetical protein 0.0048 0.0166 0.0419
Schistosoma mansoni thyroid hormone receptor 0.002 0.0037 0.0039
Echinococcus multilocularis aryl hydrocarbon receptor 0.0037 0.0117 0.0117
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.027 0.0682
Schistosoma mansoni aldehyde dehydrogenase 0.0075 0.0291 0.0304
Trypanosoma brucei monoglyceride lipase, putative 0.0084 0.0335 0.0844
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0015 0.0037
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0048 0.0122
Entamoeba histolytica hypothetical protein 0.0048 0.0166 0.0419
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0023 0.0059
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0037 0.0544
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0014 0.0008 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0036 0.0114 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0008 0.0021
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0229 0.1001 0.2525
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0041 0.0104
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0871 0.3966 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0037 0.0094
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.027 0.0282
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0037 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Onchocerca volvulus 0.0072 0.0277 0.5069
Trypanosoma brucei DNA polymerase eta, putative 0.0024 0.0057 0.0145
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0277 0.0698
Brugia malayi ecdysteroid receptor 0.002 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0105 0.043 0.1085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0016 0.0019 0.0441
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0037 0.0094
Brugia malayi DKFZp564C0469 protein 0.0014 0.0008 0.0021
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0084 0.0335 0.7942
Echinococcus granulosus Protein patched homolog 1 0.0063 0.0235 0.0245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0063 0.0065
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0036 0.0114 0.228
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0039 0.0127 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0085 0.0336 0.0847
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0024 0.0061
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0037 0.0544
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0871 0.3966 1
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0008 0.0021
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0026 0.0066 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.003 0.0086 0.0086
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0122
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0026 0.0065 0.0165
Schistosoma mansoni ran 0.0019 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.0056 0.0204 0.0514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0114 0.0555
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0035 0.0109 0.2449
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0277 0.0698
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0021

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 77 % Inhibition of human ABHD6 expressed in HEK293 cells assessed as remaining enzyme activity by measuring reduction in glycerol production from 1-AG hydrolysis at 1 uM pre-incubated for 30 mins before 1-AG substrate addition and measured 90 mins post substrate addition by fluorescence method ChEMBL. 26344596
IC50 (binding) = 6.4 Inhibition of human recombinant MAGL overexpressed in HEK cells using 2-AG as substrate preincubated for 10 mins before substrate addition measured after 10 mins by HPLC analysis ChEMBL. 24083878
IC50 (binding) = 6.4 Inhibition of human MAGL expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC method ChEMBL. 26344596
IC50 (binding) = 7 Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins before substrate addition measured after 10 mins by liquid scintillation counting analysis ChEMBL. 24083878
IC50 (binding) = 7 Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counting ChEMBL. 26344596
IC50 (binding) = 0.1 uM Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins before substrate addition measured after 10 mins by liquid scintillation counting analysis ChEMBL. 24083878
IC50 (binding) = 0.1 uM Inhibition of human FAAH expressed in COS7 cell membranes pre-incubated for 10 mins before [3H]-AEA substrate addition by liquid scintillation counting ChEMBL. 26344596
IC50 (binding) = 0.4 uM Inhibition of human recombinant MAGL overexpressed in HEK cells using 2-AG as substrate preincubated for 10 mins before substrate addition measured after 10 mins by HPLC analysis ChEMBL. 24083878
IC50 (binding) = 0.4 uM Inhibition of human MAGL expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC method ChEMBL. 26344596
Inhibition (binding) Inhibition of human ABHD12 overexpressed in HEK293 cells assessed as 2-AG hydrolysis at 1 uM by fluorescent glycerol assay ChEMBL. 24083878
Inhibition (binding) Inhibition of human ABHD6 overexpressed in HEK293 cells assessed as 2-AG hydrolysis at 1 uM by fluorescent glycerol assay ChEMBL. 24083878

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.