TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 447.444 | Formula: C24H32Cl2N4
H donors: 0 H acceptors: 2 LogP: 7.23 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(c1cc(C)nc2c1nn(c2c1ccc(cc1Cl)Cl)C(C)C)CCCC
InChi: 1S/C24H32Cl2N4/c1-6-8-12-29(13-9-7-2)21-14-17(5)27-23-22(21)28-30(16(3)4)24(23)19-11-10-18(25)15-20(19)26/h10-11,14-16H,6-9,12-13H2,1-5H3
InChiKey: WDIQROGJMLSXOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	corticotropin releasing hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	corticotropin releasing hormone receptor 1	444 aa	445 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0145	0.0108	0.0159
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0145	0.0108	0.0159
Echinococcus multilocularis	dnaJ subfamily B	0.0417	0.0385	0.0385
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0458	0.0427	0.047
Schistosoma mansoni	alpha-amylase	0.0072	0.0034	0.0035
Echinococcus granulosus	glycogen phosphorylase	0.0342	0.0309	0.0309
Loa Loa (eye worm)	ceramide glucosyltransferase	0.1721	0.1709	0.1707
Loa Loa (eye worm)	alpha-L-fucosidase	0.4618	0.4654	0.4652
Trichomonas vaginalis	alpha-glucosidase, putative	0.114	0.112	0.1825
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0018	0.0015
Trichomonas vaginalis	alpha-glucosidase, putative	0.114	0.112	0.1825
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0009	0.0009
Echinococcus multilocularis	transfer RNA-Trp	0.0145	0.0108	0.0108
Schistosoma mansoni	bile acid beta-glucosidase-related	0.1073	0.1051	0.1163
Trichomonas vaginalis	alpha-glucosidase, putative	0.114	0.112	0.1825
Schistosoma mansoni	thyroid hormone receptor	0.0271	0.0236	0.0259
Leishmania major	glycosyl hydrolase-like protein	0.114	0.112	0.4946
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0013	0.0018
Brugia malayi	phosphofructokinase	0.0107	0.0069	0.0067
Trichomonas vaginalis	glucosylceramidase, putative	0.4127	0.4154	0.6818
Schistosoma mansoni	hypothetical protein	0.0846	0.0821	0.0907
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0051	0.0049
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.0013	0.0018
Schistosoma mansoni	lamin	0.0056	0.0018	0.0017
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0013	0.0004
Schistosoma mansoni	glycogen phosphorylase	0.0148	0.0111	0.012
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.0084	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.0018	0.0015
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0251	0.0216	0.0216
Brugia malayi	intermediate filament protein	0.0056	0.0018	0.0015
Toxoplasma gondii	Amylo-alpha-1,6-glucosidase	0.078	0.0753	0.3315
Trypanosoma brucei	lysosomal alpha-mannosidase precursor, putative	0.0133	0.0096	0.0387
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0067	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0137	0.01	0.0097
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.0072	0.0732
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0458	0.0427	0.047
Mycobacterium ulcerans	alpha-L-fucosidase	0.5826	0.5881	1
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.5826	0.5881	0.5881
Echinococcus granulosus	beta mannosidase	0.0076	0.0038	0.0038
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0342	0.0309	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0108	0.0105
Echinococcus multilocularis	alpha mannosidase 2	0.0136	0.0099	0.0099
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.0069	0.0267
Brugia malayi	hypothetical protein	0.0047	0.0009	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0009	0.0006
Echinococcus multilocularis	glycogen debranching enzyme	0.078	0.0753	0.0753
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0022	0.0019
Brugia malayi	glutathione reductase	0.0048	0.0009	0.0007
Schistosoma mansoni	alpha glucosidase	0.2257	0.2254	0.2496
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.0069	0.0069
Trichomonas vaginalis	alpha-mannosidase, putative	0.024	0.0205	0.0319
Entamoeba histolytica	glycogenphosphorylase, putative	0.0148	0.0111	0.0371
Echinococcus multilocularis	lysosomal alpha glucosidase	0.9879	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.603	0.6088	1
Loa Loa (eye worm)	beta-glucuronidase	0.055	0.052	0.0517
Brugia malayi	Thioredoxin reductase	0.0048	0.0009	0.0007
Brugia malayi	Glycosyl hydrolases family 31 protein	0.114	0.112	0.1117
Mycobacterium tuberculosis	Possible conserved exported protein	0.0885	0.086	1
Echinococcus multilocularis	beta galactosidase	0.1288	0.127	0.127
Loa Loa (eye worm)	alpha amylase	0.0072	0.0034	0.0031
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0009	0.0007
Echinococcus granulosus	ceramide glucosyltransferase	0.1721	0.1709	0.1709
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0174	0.0138	0.015
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0145	0.0108	0.0159
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0389	0.0356	0.0391
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0013	0.0012
Brugia malayi	6-phosphofructokinase	0.0107	0.0069	0.0067
Loa Loa (eye worm)	alpha amylase	0.0072	0.0034	0.0031
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.114	0.112	0.4902
Echinococcus multilocularis	endoplasmic reticulum mannosyl oligosaccharide	0.0145	0.0108	0.0108
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0013	0.0004
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.0013	0.0018
Trichomonas vaginalis	glucosylceramidase, putative	0.603	0.6088	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0017	0.0035
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.2257	0.2254	0.3692
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0145	0.0108	0.0159
Brugia malayi	lysosomal alpha-mannosidase	0.0136	0.0099	0.0097
Schistosoma mansoni	glycogen phosphorylase	0.0342	0.0309	0.0339
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.0069	0.0067
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.2026	0.2019	0.3305
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0099	0.0097
Trichomonas vaginalis	maltase-glucoamylase, putative	0.2257	0.2254	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0137	0.01	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0137	0.01	0.0097
Loa Loa (eye worm)	hypothetical protein	0.1288	0.127	0.1268
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.114	0.112	0.1825
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0026	0.0024
Chlamydia trachomatis	glycogen phosphorylase	0.0342	0.0309	0.5
Brugia malayi	Alpha-L-fucosidase family protein	0.4618	0.4654	0.4652
Schistosoma mansoni	alpha-glucosidase	0.8917	0.9021	1
Onchocerca volvulus		0.0137	0.01	0.0118
Schistosoma mansoni	alpha-amylase	0.0072	0.0034	0.0035
Schistosoma mansoni	hypothetical protein	0.0563	0.0533	0.0588
Schistosoma mansoni	hypothetical protein	0.1003	0.098	0.1084
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0067	0.0029	0.0026
Trichomonas vaginalis	glycoside hydrolase, putative	0.1551	0.1537	0.2511
Schistosoma mansoni	alpha-amylase	0.0072	0.0034	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0245	0.021	0.0208
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0029	0.0086
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0458	0.0427	0.0427
Echinococcus granulosus	bile acid beta glucosidase	0.1073	0.1051	0.1051
Loa Loa (eye worm)	glycosyl hydrolase family 38 protein	0.024	0.0205	0.0202
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.0072	0.7522
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.0072	0.0732
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0069	0.0096
Brugia malayi	Trehalase protein 5	0.0047	0.0009	0.0006
Trichomonas vaginalis	beta-galactosidase, putative	0.1143	0.1122	0.1829
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.114	0.112	0.1596
Brugia malayi	Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1	0.0145	0.0108	0.0105
Echinococcus granulosus	dnaJ subfamily B	0.0417	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0087	0.0085
Brugia malayi	TAR-binding protein	0.0065	0.0026	0.0024
Echinococcus multilocularis	ceramide glucosyltransferase	0.1721	0.1709	0.1709
Trichomonas vaginalis	alpha-glucosidase, putative	0.114	0.112	0.1825
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0026	0.0024
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0067	0.0029	0.0086
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.0069	0.007
Trichomonas vaginalis	glucosylceramidase, putative	0.603	0.6088	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.0069	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.114	0.112	0.4946
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.2257	0.2254	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0009	0.0009
Brugia malayi	Trehalase family protein	0.0137	0.01	0.0097
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0026	0.0024
Echinococcus multilocularis	glycogen phosphorylase	0.0342	0.0309	0.0309
Echinococcus multilocularis	lamin	0.0056	0.0018	0.0018
Trichomonas vaginalis	glucosylceramidase, putative	0.4046	0.4072	0.6684
Echinococcus granulosus	alpha glucosidase	0.0072	0.0034	0.0034
Loa Loa (eye worm)	amylo-alpha-1,6-glucosidase	0.038	0.0347	0.0344
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0013	0.0004
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0245	0.021	0.0208
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0458	0.0427	0.047
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0145	0.0108	0.016
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0024	0.0024
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0069	0.0096
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.2103	0.2098	0.9299
Echinococcus granulosus	non lysosomal glucosylceramidase	0.1073	0.1051	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0088	0.0085
Brugia malayi	trehalase I	0.0047	0.0009	0.0006
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0026	0.0026
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0026	0.0026
Onchocerca volvulus	Glucosylceramidase homolog	0.4046	0.4072	0.5874
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.603	0.6088	0.6087
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0011	0.0008
Echinococcus granulosus	intermediate filament protein	0.0056	0.0018	0.0018
Echinococcus multilocularis	lysosomal alpha glucosidase	0.9879	1	1
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.1073	0.1051	0.1051
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.0069	0.0074
Onchocerca volvulus		0.0136	0.0099	0.0118
Entamoeba histolytica	glycogen phosphorylase, putative	0.0148	0.0111	0.0371
Loa Loa (eye worm)	hypothetical protein	0.114	0.112	0.1117
Brugia malayi	Trehalase family protein	0.0137	0.01	0.0097
Trypanosoma cruzi	lysosomal alpha-mannosidase precursor, putative	0.0174	0.0138	0.0572
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.0013	0.0013
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.078	0.0753	0.1222
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0458	0.0427	0.047
Trypanosoma brucei	glucosidase, putative	0.2257	0.2254	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0251	0.0216	0.0216
Brugia malayi	Glycosyl hydrolases family 38 protein	0.024	0.0205	0.0202
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0389	0.0356	0.0567
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.114	0.112	0.4946
Trichomonas vaginalis	glucosylceramidase, putative	0.4046	0.4072	0.6684
Giardia lamblia	Glycogen phosphorylase	0.0342	0.0309	0.3989
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0017	0.0014
Echinococcus granulosus	endoplasmic reticulum mannosyl oligosaccharide	0.0145	0.0108	0.0108
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.0069	0.0074
Loa Loa (eye worm)	trehalase	0.0137	0.01	0.0097
Schistosoma mansoni	alpha-amylase	0.0072	0.0034	0.0035
Loa Loa (eye worm)	glycogen phosphorylase	0.0342	0.0309	0.0306
Loa Loa (eye worm)	trehalase	0.0137	0.01	0.0097
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.0013	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.0368	0.0587
Echinococcus multilocularis	lysosomal alpha mannosidase	0.0174	0.0138	0.0138
Trichomonas vaginalis	sucrase-isomaltase, putative	0.2103	0.2098	0.3435
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0026	0.0026
Trypanosoma brucei	glycosyl hydrolase-like protein	0.114	0.112	0.4946
Trichomonas vaginalis	alpha-glucosidase, putative	0.2257	0.2254	0.3692
Brugia malayi	Trehalase family protein	0.0047	0.0009	0.0006
Echinococcus granulosus	lysosomal alpha glucosidase	0.9879	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.114	0.112	0.1825
Loa Loa (eye worm)	manba-prov protein	0.0076	0.0038	0.0035
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.114	0.112	0.1825
Echinococcus granulosus	glycogen phosphorylase	0.0342	0.0309	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0356	0.0353
Echinococcus granulosus	beta D xylosidase 2	0.0067	0.0028	0.0028
Echinococcus granulosus	mannosyl oligosaccharide 12 alpha mannosidase	0.0145	0.0108	0.0108
Brugia malayi	Ceramide glucosyltransferase	0.1721	0.1709	0.1707
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.0069	0.0067
Brugia malayi	MAP kinase sur-1	0.0052	0.0013	0.0011
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0342	0.0309	0.0309
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0026	0.0026
Brugia malayi	carbohydrate phosphorylase	0.0342	0.0309	0.0306
Trichomonas vaginalis	beta-glucosidase, putative	0.0803	0.0777	0.1261
Schistosoma mansoni	thyroid hormone receptor	0.0271	0.0236	0.0259
Mycobacterium tuberculosis	Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas	0.0072	0.0034	0.029
Trichomonas vaginalis	alpha-glucosidase, putative	0.2257	0.2254	0.3692
Mycobacterium tuberculosis	Trehalose synthase TreS	0.0072	0.0034	0.029
Schistosoma mansoni	hypothetical protein	0.0067	0.0028	0.0029
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0458	0.0427	0.0427
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0145	0.0108	0.0159
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.078	0.0753	0.1222
Echinococcus granulosus	beta galactosidase	0.1288	0.127	0.127
Onchocerca volvulus		0.0137	0.01	0.0118
Brugia malayi	hypothetical protein	0.0137	0.01	0.0097
Schistosoma mansoni	ceramide glucosyltransferase	0.1721	0.1709	0.1892
Onchocerca volvulus		0.0137	0.01	0.0118
Giardia lamblia	4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase	0.078	0.0753	1
Echinococcus granulosus	lamin dm0	0.0056	0.0018	0.0018
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0145	0.0108	0.0159
Brugia malayi	6-phosphofructokinase	0.0107	0.0069	0.0067
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0029	0.0086
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0026	0.0026
Brugia malayi	Glycosyl hydrolases family 31 protein	0.2257	0.2254	0.2252
Trichomonas vaginalis	Periplasmic beta-glucosidase precursor, putative	0.0067	0.0028	0.0029
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.024	0.0205	0.0319
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.5826	0.5881	0.5881
Trichomonas vaginalis	glucosylceramidase, putative	0.4046	0.4072	0.6684
Onchocerca volvulus		0.0137	0.01	0.0118
Echinococcus multilocularis	beta mannosidase	0.0076	0.0038	0.0038
Mycobacterium ulcerans	trehalose synthase TreS	0.0072	0.0034	0.001
Brugia malayi	Trehalase family protein	0.0137	0.01	0.0097
Schistosoma mansoni	alpha-amylase	0.0072	0.0034	0.0035
Mycobacterium ulcerans	alpha-mannosidase	0.024	0.0205	0.0301
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0029	0.0086
Brugia malayi	manba-prov protein	0.0481	0.0449	0.0447
Schistosoma mansoni	beta-mannosidase	0.0376	0.0342	0.0377
Trichomonas vaginalis	glucosylceramidase, putative	0.4046	0.4072	0.6684
Trichomonas vaginalis	glucosylceramidase, putative	0.603	0.6088	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0067	0.0029	0.0029
Loa Loa (eye worm)	mannosidase	0.0145	0.0108	0.0105
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.0072	0.0732
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.603	0.6088	0.6087
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0072	0.0034	0.0031
Trypanosoma cruzi	lysosomal alpha-mannosidase precursor, putative	0.0174	0.0138	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0011	0.0008
Brugia malayi	Melibiase family protein	0.0389	0.0356	0.0353
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0013	0.0018
Trichomonas vaginalis	maltase-glucoamylase, putative	0.114	0.112	0.1825
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0148	0.0111	0.0141
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.0072	0.0732
Echinococcus granulosus	glycogen debranching enzyme	0.078	0.0753	0.0753
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0204	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0137	0.01	0.0097
Echinococcus multilocularis	glycogen phosphorylase	0.0342	0.0309	0.0309
Echinococcus granulosus	neutral alpha glucosidase AB	0.2257	0.2254	0.2254
Trypanosoma cruzi	hypothetical protein, conserved	0.2257	0.2254	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0011	0.0008
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0584	0.0554	0.0552
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.2257	0.2254	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.0069	0.0705
Brugia malayi	hypothetical protein	0.0047	0.0009	0.0006
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.0069	0.0067
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.0069	0.0184
Entamoeba histolytica	glycogen phosphorylase, putative	0.0148	0.0111	0.0371
Echinococcus multilocularis	lamin dm0	0.0056	0.0018	0.0018
Echinococcus granulosus	expressed protein	0.0377	0.0344	0.0344
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0342	0.0309	0.049
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0145	0.0108	0.0159
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0389	0.0356	0.0391
Schistosoma mansoni	intermediate filament proteins	0.0056	0.0018	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0099	0.0097
Brugia malayi	hypothetical protein	0.0175	0.0139	0.0136
Onchocerca volvulus	Trehalase homolog	0.0137	0.01	0.0118
Entamoeba histolytica	glycogen phosphorylase, putative	0.0342	0.0309	0.1258
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.0084	0.0877
Schistosoma mansoni	lamin	0.0056	0.0018	0.0017
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0271	0.0236	0.0236
Schistosoma mansoni	bile acid beta-glucosidase-related	0.1073	0.1051	0.1163
Brugia malayi	Trehalase family protein	0.0047	0.0009	0.0006
Schistosoma mansoni	alpha-l-fucosidase	0.4618	0.4654	0.5157
Loa Loa (eye worm)	hypothetical protein	0.0724	0.0697	0.0695
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.0069	0.0267
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0136	0.0099	0.0097
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0016	0.0016
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0148	0.0111	0.1197
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0145	0.0108	0.0159
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.0013	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0108	0.0106
Trichomonas vaginalis	alpha-glucosidase, putative	0.2257	0.2254	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0009	0.0006
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0136	0.0099	0.0097
Trypanosoma cruzi	hypothetical protein, conserved	0.2257	0.2254	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.0013	0.0013
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.0013	0.0011
Loa Loa (eye worm)	TRE-2 protein	0.0137	0.01	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.01	0.0146
Onchocerca volvulus		0.6849	0.6921	1
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.0069	0.0184
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0026	0.0024
Echinococcus multilocularis	mannosyl oligosaccharide 1,2 alpha mannosidase	0.0145	0.0108	0.0108
Echinococcus granulosus	lysosomal alpha mannosidase	0.0174	0.0138	0.0138
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0022	0.0019
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0009	0.0007
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0026	0.0026
Loa Loa (eye worm)	trehalase	0.0047	0.0009	0.0006
Entamoeba histolytica	glycogen phosphorylase, putative	0.0342	0.0309	0.1258
Trichomonas vaginalis	glucosylceramidase, putative	0.4046	0.4072	0.6684
Loa Loa (eye worm)	TRE-1 protein	0.0137	0.01	0.0097
Leishmania major	alpha glucosidase II subunit, putative	0.2257	0.2254	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.2257	0.2254	0.3692
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.9879	1	1
Echinococcus granulosus	lamin	0.0056	0.0018	0.0018
Trichomonas vaginalis	glucosylceramidase, putative	0.4046	0.4072	0.6684
Mycobacterium tuberculosis	Probable reductase	0.0109	0.0072	0.0732
Trypanosoma brucei	lysosomal alpha-mannosidase precursor, putative	0.0174	0.0138	0.0572
Trichomonas vaginalis	conserved hypothetical protein	0.1143	0.1122	0.1829
Brugia malayi	Alpha amylase, catalytic domain containing protein	0.0072	0.0034	0.0031
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.0013	0.0018
Schistosoma mansoni	alpha-glucosidase	0.8917	0.9021	1
Loa Loa (eye worm)	trehalase	0.0137	0.01	0.0097
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0145	0.0108	0.0159
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0458	0.0427	0.0427
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.0084	0.0877
Echinococcus multilocularis	bile acid beta glucosidase	0.1073	0.1051	0.1051
Brugia malayi	trehalase	0.0047	0.0009	0.0006
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.2026	0.2019	0.3305
Echinococcus granulosus	alpha mannosidase 2	0.0041	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0137	0.01	0.0097
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0069	0.0096
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.0069	0.7072
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.0018	0.0015
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.0069	0.0069
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0407	0.0374	1
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.0018	0.0015
Brugia malayi	Trehalase family protein	0.0137	0.01	0.0097
Trichomonas vaginalis	trehalase, putative	0.0137	0.01	0.0146
Trichomonas vaginalis	glycoside hydrolases, putative	0.0803	0.0777	0.1261
Schistosoma mansoni	ceramide glucosyltransferase	0.1721	0.1709	0.1892
Echinococcus multilocularis	beta D xylosidase 2	0.0067	0.0028	0.0028
Schistosoma mansoni	mannosyl-oligosaccharide alpha-12-mannosidase	0.0145	0.0108	0.0116
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0153	0.0116	0.0173
Entamoeba histolytica	alpha-1,2-mannosidase, putative	0.0885	0.086	0.3735
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.0069	0.0184
Toxoplasma gondii	melibiase subfamily protein	0.0458	0.0427	0.1859
Echinococcus multilocularis	expressed protein	0.0377	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0108	0.0105
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0145	0.0108	0.0159
Schistosoma mansoni	hypothetical protein	0.0417	0.0385	0.0424
Trichomonas vaginalis	glucosylceramidase, putative	0.603	0.6088	1
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.0108	0.0159
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.0084	0.0877
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.2257	0.2254	0.3692
Brugia malayi	RNA binding protein	0.0065	0.0026	0.0024
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.2257	0.2254	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0049	0.0047
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0145	0.0108	0.0159
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.0013	0.0018
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.078	0.0753	0.0751
Entamoeba histolytica	glycogen debranching enzyme, putative	0.078	0.0753	0.3257
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0016	0.0016
Trypanosoma brucei	protein kinase, putative	0.0052	0.0013	0.0018
Schistosoma mansoni	hypothetical protein	0.0251	0.0216	0.0236
Echinococcus granulosus	Glycosyl transferase family 35	0.0342	0.0309	0.0309
Plasmodium vivax	hypothetical protein, conserved	0.0407	0.0374	1
Loa Loa (eye worm)	hypothetical protein	0.078	0.0753	0.0751
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.0013	0.0018
Trichomonas vaginalis	glucosylceramidase, putative	0.603	0.6088	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.0069	0.0096
Onchocerca volvulus		0.0137	0.01	0.0118
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.0072	0.0732
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.1721	0.1709	0.245
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0067	0.0029	0.0026
Giardia lamblia	Ceramide glucosyltransferase	0.078	0.0753	0.9998
Trichomonas vaginalis	glucosylceramidase, putative	0.4046	0.4072	0.6684
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0145	0.0108	0.0159
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.0069	0.0267
Trichomonas vaginalis	beta-mannosidase, putative	0.0376	0.0342	0.0546
Echinococcus multilocularis	musashi	0.0056	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0009	0.0006
Brugia malayi	Beta-glucuronidase precursor	0.055	0.052	0.0517
Loa Loa (eye worm)	hypothetical protein	0.1616	0.1603	0.16
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.0013	0.0013
Trichomonas vaginalis	alpha-glucosidase, putative	0.2257	0.2254	0.3692
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0067	0.0029	0.0029
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0342	0.0309	0.049
Schistosoma mansoni	beta-galactosidase	0.1288	0.127	0.1405
Schistosoma mansoni	lipoxygenase	0.0054	0.0016	0.0015
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0584	0.0554	0.0552
Onchocerca volvulus		0.0136	0.0099	0.0118
Brugia malayi	hypothetical protein	0.0047	0.0009	0.0006
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0087	0.0049	0.0052
Echinococcus multilocularis	neutral alpha glucosidase AB	0.2257	0.2254	0.2254
Schistosoma mansoni	mannosidase alpha class 2a	0.0136	0.0099	0.0107
Entamoeba histolytica	beta-galactosidase, putative	0.0738	0.0711	0.3067
Entamoeba histolytica	oligo-1,6-glucosidase, putative	0.0072	0.0034	0.0025
Schistosoma mansoni	glycogen phosphorylase	0.0342	0.0309	0.0339
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0145	0.0108	0.0159
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0013	0.0004
Loa Loa (eye worm)	trehalase	0.0047	0.0009	0.0006
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0204	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0009	0.0006
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0026	0.0026
Echinococcus granulosus	alpha mannosidase 2	0.0049	0.0011	0.0011
Echinococcus multilocularis	alpha glucosidase	0.0072	0.0034	0.0034
Trichomonas vaginalis	glucosylceramidase, putative	0.4127	0.4154	0.6818
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0136	0.0099	0.0107

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 37 nM	Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells	ChEMBL.	12951127
Ki (binding)	= 37 nM	Binding affinity to the human corticotropin releasing factor receptor 1 expressed in HEK273 cells	ChEMBL.	12951127

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 189153