Detailed information for compound 189251

Basic information

Technical information
  • TDR Targets ID: 189251
  • Name: 2-(4-aminophenyl)-1,3-benzothiazole-5,7-diol
  • MW: 258.296 | Formula: C13H10N2O2S
  • H donors: 3 H acceptors: 3 LogP: 2.65 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)c1nc2c(s1)c(O)cc(c2)O
  • InChi: 1S/C13H10N2O2S/c14-8-3-1-7(2-4-8)13-15-10-5-9(16)6-11(17)12(10)18-13/h1-6,16-17H,14H2
  • InChiKey: RHEKZYYBZBSZSX-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0552 0.0463 0.0511
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0911 0.0787 0.1361
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0012 0.0012
Trichomonas vaginalis alpha-mannosidase, putative 0.0247 0.0188 0.0311
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.1293 0.1132 0.4718
Echinococcus granulosus dnaJ subfamily B 0.0438 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0258 0.0198 0.0214
Echinococcus granulosus neutral alpha glucosidase AB 0.2687 0.239 0.239
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0025 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0018 0.005
Schistosoma mansoni bile acid beta-glucosidase-related 0.1095 0.0953 0.1058
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0075 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0088 0.0081
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0149 0.01 0.01
Leishmania major glycosyl hydrolase-like protein 0.1293 0.1132 0.4718
Loa Loa (eye worm) trehalase 0.0137 0.0088 0.0081
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0181 0.0128 0.0137
Schistosoma mansoni hypothetical protein 0.1171 0.1022 0.1136
Brugia malayi phosphofructokinase 0.0107 0.0062 0.0054
Echinococcus multilocularis lysosomal alpha glucosidase 1.1119 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0015 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.4272 0.3821 0.6676
Trichomonas vaginalis glucosylceramidase, putative 0.6374 0.5717 1
Loa Loa (eye worm) alpha amylase 0.0072 0.003 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.036 0.036
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0012 0.0015
Onchocerca volvulus Glycogen phosphorylase homolog 0.0342 0.0274 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.4272 0.3821 0.6676
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0025 0.0018
Brugia malayi Trehalase family protein 0.0137 0.0088 0.0081
Echinococcus granulosus lamin 0.0056 0.0016 0.0016
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0062 0.0224
Trichomonas vaginalis alpha-L-fucosidase, putative 0.2639 0.2347 0.4093
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0596 0.0503 0.0495
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0149 0.01 0.0156
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0247 0.0188 0.0311
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0008 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0062 0.0054
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0026 0.0026
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0025 0.0025
Trypanosoma brucei glycosyl hydrolase-like protein 0.1293 0.1132 0.4718
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.2687 0.239 0.4169
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0062 0.0153
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.7583 0.6809 0.6809
Schistosoma mansoni mannosidase alpha class 2a 0.0141 0.0092 0.0097
Loa Loa (eye worm) trehalase 0.0137 0.0088 0.0081
Loa Loa (eye worm) hypothetical protein 0.146 0.1282 0.1276
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0911 0.0787 0.078
Brugia malayi hypothetical protein 0.0204 0.015 0.0142
Echinococcus multilocularis beta D xylosidase 2 0.0067 0.0025 0.0025
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.2687 0.239 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0148 0.0099 0.031
Schistosoma mansoni hypothetical protein 0.0869 0.075 0.0831
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0014 0.0014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0026 0.0018
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0062 0.0062
Brugia malayi Glycosyl hydrolases family 38 protein 0.0141 0.0092 0.0084
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.1745 0.154 0.2194
Trichomonas vaginalis alpha-glucosidase, putative 0.2687 0.239 0.4169
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0072 0.003 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0278 0.0216 0.0235
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.0072 0.003 0.0021
Entamoeba histolytica glycogen debranching enzyme, putative 0.0911 0.0787 0.3223
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0149 0.01 0.0156
Brugia malayi Beta-glucuronidase precursor 0.0561 0.0472 0.0464
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0026 0.0023
Trichomonas vaginalis glycogen phosphorylase, putative 0.0342 0.0274 0.0461
Trichomonas vaginalis alpha-glucosidase, putative 0.1293 0.1132 0.1964
Brugia malayi Glycosyl hydrolases family 31 protein 0.1293 0.1132 0.1125
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0072 0.003 0.0276
Trichomonas vaginalis alpha-glucosidase, putative 0.2687 0.239 0.4169
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 1.1119 1 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0342 0.0274 0.0274
Echinococcus multilocularis lamin 0.0056 0.0016 0.0016
Schistosoma mansoni glycogen phosphorylase 0.0342 0.0274 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0012 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0062 0.0089
Brugia malayi Glycosyl hydrolases family 38 protein 0.0141 0.0092 0.0084
Loa Loa (eye worm) ceramide glucosyltransferase 0.1745 0.154 0.1534
Plasmodium vivax hypothetical protein, conserved 0.0459 0.038 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0025 0.0072
Onchocerca volvulus 0.0137 0.0088 0.0105
Brugia malayi carbohydrate phosphorylase 0.0342 0.0274 0.0266
Schistosoma mansoni alpha-amylase 0.0072 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0141 0.0092 0.0084
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0062 0.0054
Echinococcus multilocularis alpha mannosidase 2 0.0141 0.0092 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.4272 0.3821 0.6676
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0012 0.0012
Echinococcus granulosus glycogen phosphorylase 0.0342 0.0274 0.0274
Trichomonas vaginalis alpha-glucosidase, putative 0.1293 0.1132 0.1964
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0025 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.0387 0.0659
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0012 0.0015
Trichomonas vaginalis alpha-L-fucosidase, putative 0.2639 0.2347 0.4093
Echinococcus multilocularis transfer RNA-Trp 0.0149 0.01 0.01
Brugia malayi hypothetical protein 0.0137 0.0088 0.0081
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0062 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.6374 0.5717 1
Giardia lamblia Glycogen phosphorylase 0.0342 0.0274 0.338
Echinococcus multilocularis alpha glucosidase 0.0072 0.003 0.003
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0149 0.01 0.0156
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0658 0.0559 0.0618
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0062 0.0224
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.6374 0.5717 0.5714
Echinococcus multilocularis lysosomal alpha glucosidase 1.1119 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.6374 0.5717 1
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0181 0.0128 0.0504
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0062 0.0062
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.2687 0.239 0.2384
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0149 0.01 0.01
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0911 0.0787 0.3278
Schistosoma mansoni lamin 0.0056 0.0016 0.0011
Echinococcus granulosus intermediate filament protein 0.0056 0.0016 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0012 0.0001
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0064 0.0695
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0149 0.01 0.0156
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0258 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0056 0.0016 0.0008
Schistosoma mansoni lamin 0.0056 0.0016 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0012 0.0001
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0141 0.0092 0.0097
Brugia malayi TAR-binding protein 0.0068 0.0026 0.0018
Echinococcus granulosus glycogen debranching enzyme 0.0911 0.0787 0.0787
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0075 0.0833
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0012 0.0025
Brugia malayi 6-phosphofructokinase 0.0107 0.0062 0.0054
Echinococcus multilocularis thyroid hormone receptor alpha 0.0278 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.1172 0.1023 0.1773
Entamoeba histolytica alpha-1,2-mannosidase, putative 0.0929 0.0804 0.3292
Loa Loa (eye worm) manba-prov protein 0.008 0.0037 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.4365 0.3904 0.6823
Echinococcus granulosus Glycosyl transferase family 35 0.0342 0.0274 0.0274
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1293 0.1132 0.1964
Schistosoma mansoni alpha-l-fucosidase 0.6015 0.5394 0.6022
Echinococcus granulosus ceramide glucosyltransferase 0.1745 0.154 0.154
Schistosoma mansoni alpha-amylase 0.0072 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0552 0.0463 0.0456
Schistosoma mansoni hypothetical protein 0.0658 0.0559 0.0618
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0149 0.01 0.0156
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0148 0.0099 0.0108
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.1293 0.1132 0.1964
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0149 0.01 0.0156
Echinococcus granulosus non lysosomal glucosylceramidase 0.1095 0.0953 0.0953
Echinococcus multilocularis lamin dm0 0.0056 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.1293 0.1132 0.1125
Trichomonas vaginalis maltase-glucoamylase, putative 0.1293 0.1132 0.1964
Trichomonas vaginalis alpha-glucosidase, putative 0.1293 0.1132 0.1964
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0062 0.0089
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0062 0.0062
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0064 0.0695
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0596 0.0503 0.0495
Mycobacterium ulcerans alpha-mannosidase 0.0247 0.0188 0.024
Echinococcus granulosus bile acid beta glucosidase 0.1095 0.0953 0.0953
Loa Loa (eye worm) hypothetical protein 0.1797 0.1587 0.158
Trichomonas vaginalis alpha-glucosidase, putative 0.1293 0.1132 0.1964
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0075 0.0833
Brugia malayi Melibiase family protein 0.0552 0.0463 0.0456
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0025 0.0072
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0149 0.01 0.0156
Echinococcus multilocularis bile acid beta glucosidase 0.1095 0.0953 0.0953
Echinococcus granulosus beta D xylosidase 2 0.0067 0.0025 0.0025
Loa Loa (eye worm) trehalase 0.0137 0.0088 0.0081
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0658 0.0559 0.0618
Schistosoma mansoni alpha-amylase 0.0072 0.003 0.0027
Schistosoma mansoni alpha-glucosidase 0.9959 0.8953 1
Brugia malayi Alpha-L-fucosidase family protein 0.6015 0.5394 0.539
Echinococcus multilocularis glycogen phosphorylase 0.0342 0.0274 0.0274
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0247 0.0188 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0026 0.0023
Schistosoma mansoni alpha-amylase 0.0072 0.003 0.0027
Trichomonas vaginalis glycoside hydrolase, putative 0.1591 0.1401 0.2435
Echinococcus granulosus fucosidase alpha L 1 tissue 0.7583 0.6809 0.6809
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0012 0.0004
Entamoeba histolytica glycogen phosphorylase, putative 0.0148 0.0099 0.031
Loa Loa (eye worm) hypothetical protein 0.0051 0.0011 0.0003
Echinococcus granulosus alpha mannosidase 2 0.0051 0.0011 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.1293 0.1132 0.1964
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0062 0.0089
Loa Loa (eye worm) alpha amylase 0.0072 0.003 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0012 0.0001
Loa Loa (eye worm) hypothetical protein 0.0137 0.0088 0.0081
Echinococcus multilocularis neutral alpha glucosidase AB 0.2687 0.239 0.239
Onchocerca volvulus Trehalase homolog 0.0137 0.0088 0.0105
Echinococcus multilocularis musashi 0.0056 0.0016 0.0016
Echinococcus multilocularis beta galactosidase 0.146 0.1282 0.1282
Trichomonas vaginalis beta-galactosidase, putative 0.1172 0.1023 0.1773
Trichomonas vaginalis sucrase-isomaltase, putative 0.2452 0.2178 0.3798
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0075 0.0833
Loa Loa (eye worm) hypothetical protein 0.0137 0.0088 0.0081
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0062 0.0062
Trichomonas vaginalis glycogen phosphorylase, putative 0.0342 0.0274 0.0461
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.2687 0.239 1
Schistosoma mansoni glycogen phosphorylase 0.0148 0.0099 0.0104
Echinococcus granulosus beta galactosidase 0.146 0.1282 0.1282
Trichomonas vaginalis beta-glucosidase, putative 0.0946 0.0819 0.1415
Echinococcus granulosus alpha glucosidase 0.0072 0.003 0.003
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.1293 0.1132 0.1606
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0658 0.0559 0.0559
Schistosoma mansoni hypothetical protein 0.0438 0.036 0.0396
Brugia malayi lysosomal alpha-mannosidase 0.0141 0.0092 0.0084
Loa Loa (eye worm) hypothetical protein 0.0149 0.01 0.0092
Brugia malayi Ceramide glucosyltransferase 0.1745 0.154 0.1534
Schistosoma mansoni beta-mannosidase 0.0385 0.0313 0.0343
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0658 0.0559 0.0559
Brugia malayi 6-phosphofructokinase 0.0107 0.0062 0.0054
Echinococcus granulosus beta mannosidase 0.008 0.0037 0.0037
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0149 0.01 0.0156
Loa Loa (eye worm) hypothetical protein 0.0051 0.0011 0.0003
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.2687 0.239 0.4169
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0149 0.01 0.0156
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0064 0.7522
Schistosoma mansoni alpha glucosidase 0.2687 0.239 0.2664
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0025 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0149 0.01 0.0156
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0552 0.0463 0.0511
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0148 0.0099 0.1137
Trichomonas vaginalis glucosylceramidase, putative 0.6374 0.5717 1
Schistosoma mansoni ceramide glucosyltransferase 0.1745 0.154 0.1715
Mycobacterium tuberculosis Possible conserved exported protein 0.0929 0.0804 1
Loa Loa (eye worm) TRE-2 protein 0.0137 0.0088 0.0081
Trichomonas vaginalis glycoside hydrolases, putative 0.0946 0.0819 0.1415
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0026 0.0018
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0149 0.01 0.0156
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0149 0.01 0.0092
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.009 0.0046 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0088 0.0136
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.2452 0.2178 0.9106
Schistosoma mansoni bile acid beta-glucosidase-related 0.1095 0.0953 0.1058
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0014 0.0014
Onchocerca volvulus 0.0137 0.0088 0.0105
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0552 0.0463 0.0792
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0016 0.0008
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0062 0.0153
Echinococcus multilocularis beta mannosidase 0.008 0.0037 0.0037
Onchocerca volvulus Glucosylceramidase homolog 0.4272 0.3821 0.5477
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0062 0.0089
Echinococcus granulosus lysosomal alpha glucosidase 1.1119 1 1
Schistosoma mansoni intermediate filament proteins 0.0056 0.0016 0.0011
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.2687 0.239 1
Onchocerca volvulus 0.0141 0.0092 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.2687 0.239 1
Loa Loa (eye worm) beta-glucuronidase 0.0561 0.0472 0.0464
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0064 0.0695
Loa Loa (eye worm) hypothetical protein 0.0137 0.0088 0.0081
Entamoeba histolytica glycogenphosphorylase, putative 0.0148 0.0099 0.031
Schistosoma mansoni alpha-amylase 0.0072 0.003 0.0027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.1293 0.1132 0.468
Schistosoma mansoni alpha-glucosidase 0.9959 0.8953 1
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0012 0.0012
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0157 0.0107 0.0168
Echinococcus multilocularis lysosomal alpha mannosidase 0.0181 0.0128 0.0128
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0149 0.01 0.01
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0012 0.0015
Loa Loa (eye worm) glycogen phosphorylase 0.0342 0.0274 0.0266
Trichomonas vaginalis glucosylceramidase, putative 0.4365 0.3904 0.6823
Brugia malayi Trehalase family protein 0.0137 0.0088 0.0081
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0025 0.0072
Toxoplasma gondii thioredoxin reductase 0.0048 0.0008 0.001
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0072 0.003 0.0022
Schistosoma mansoni beta-galactosidase 0.146 0.1282 0.1427
Toxoplasma gondii melibiase subfamily protein 0.0658 0.0559 0.232
Loa Loa (eye worm) hypothetical protein 0.013 0.0082 0.0075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0012 0.0015
Entamoeba histolytica glycogen phosphorylase, putative 0.0342 0.0274 0.1052
Loa Loa (eye worm) RNA binding protein 0.0068 0.0026 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.2687 0.239 0.4169
Entamoeba histolytica beta-galactosidase, putative 0.0756 0.0648 0.2632
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0137 0.0088 0.0081
Mycobacterium ulcerans trehalose synthase TreS 0.0072 0.003 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.2687 0.239 0.4169
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0658 0.0559 0.0559
Schistosoma mansoni ceramide glucosyltransferase 0.1745 0.154 0.1715
Echinococcus multilocularis expressed protein 0.0377 0.0306 0.0306
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0062 0.0224
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0016 0.0008
Onchocerca volvulus 0.0141 0.0092 0.011
Trypanosoma brucei protein kinase, putative 0.0052 0.0012 0.0015
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0911 0.0787 0.1361
Mycobacterium ulcerans alpha-L-fucosidase 0.7583 0.6809 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0011 0.0003
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0012 0.0015
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0258 0.0198 0.0198
Brugia malayi manba-prov protein 0.0496 0.0412 0.0405
Entamoeba histolytica glycogen phosphorylase, putative 0.0342 0.0274 0.1052
Loa Loa (eye worm) hypothetical protein 0.0911 0.0787 0.078
Echinococcus multilocularis glycogen debranching enzyme 0.0911 0.0787 0.0787
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.4272 0.3821 0.6676
Echinococcus granulosus tar DNA binding protein 0.0068 0.0026 0.0026
Echinococcus multilocularis ceramide glucosyltransferase 0.1745 0.154 0.154
Giardia lamblia Ceramide glucosyltransferase 0.0791 0.0679 0.8604
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0064 0.0695
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0062 1
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0138 0.009 0.0343
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0016 0.0008
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0062 0.7072
Loa Loa (eye worm) hypothetical protein 0.009 0.0046 0.0039
Loa Loa (eye worm) mannosidase 0.0149 0.01 0.0092
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0062 0.0053
Brugia malayi Glycosyl hydrolases family 31 protein 0.2687 0.239 0.2384
Schistosoma mansoni lipoxygenase 0.0054 0.0014 0.0009
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0444 0.0365 0.0358
Onchocerca volvulus 0.0137 0.0088 0.0105
Echinococcus multilocularis glycogen phosphorylase 0.0342 0.0274 0.0274
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0149 0.0099 0.0155
Trichomonas vaginalis beta-mannosidase, putative 0.0385 0.0313 0.0529
Chlamydia trachomatis glycogen phosphorylase 0.0342 0.0274 0.5
Trypanosoma brucei glucosidase, putative 0.2687 0.239 1
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0181 0.0128 0.0504
Loa Loa (eye worm) TRE-1 protein 0.0137 0.0088 0.0081
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0658 0.0559 0.0618
Echinococcus granulosus alpha mannosidase 2 0.0042 0.0003 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.2687 0.239 0.4169
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0149 0.01 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.6374 0.5717 1
Brugia malayi RNA binding protein 0.0068 0.0026 0.0018
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0911 0.0787 1
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0149 0.01 0.0105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0064 0.0695
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.1293 0.1132 0.4718
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0008 0.0008
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0459 0.038 1
Onchocerca volvulus 0.0137 0.0088 0.0105
Brugia malayi Glycosyl hydrolases family 38 protein 0.0247 0.0188 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0026 0.0023
Mycobacterium tuberculosis Trehalose synthase TreS 0.0072 0.003 0.0276
Trichomonas vaginalis trehalase, putative 0.0137 0.0088 0.0136
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0026 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.4272 0.3821 0.6676
Trichomonas vaginalis glucosylceramidase, putative 0.6374 0.5717 1
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0062 0.0054
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.6374 0.5717 0.5714
Trichomonas vaginalis glucosylceramidase, putative 0.4272 0.3821 0.6676
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0149 0.01 0.0156
Schistosoma mansoni hypothetical protein 0.0067 0.0025 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0026 0.0023
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0658 0.0559 0.0618
Echinococcus granulosus expressed protein 0.0377 0.0306 0.0306
Schistosoma mansoni glycogen phosphorylase 0.0342 0.0274 0.03
Echinococcus granulosus lamin dm0 0.0056 0.0016 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0024 0.002
Echinococcus granulosus lysosomal alpha mannosidase 0.0181 0.0128 0.0128
Trichomonas vaginalis Periplasmic beta-glucosidase precursor, putative 0.0067 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0145 0.0096 0.0089
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0062 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.4272 0.3821 0.6676
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0012 0.0015
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0012 0.0015
Leishmania major alpha glucosidase II subunit, putative 0.2687 0.239 1
Brugia malayi Trehalase family protein 0.0137 0.0088 0.0081
Onchocerca volvulus 0.7754 0.6963 1
Brugia malayi Trehalase family protein 0.0137 0.0088 0.0081
Loa Loa (eye worm) hypothetical protein 0.0141 0.0092 0.0084
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0149 0.01 0.0156
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0012 0.0001
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0149 0.01 0.0156
Loa Loa (eye worm) hypothetical protein 0.0149 0.01 0.0092
Brugia malayi MAP kinase sur-1 0.0052 0.0012 0.0004
Trichomonas vaginalis maltase-glucoamylase, putative 0.2687 0.239 0.4169
Schistosoma mansoni thyroid hormone receptor 0.0278 0.0216 0.0235
Mycobacterium tuberculosis Probable reductase 0.0109 0.0064 0.0695
Brugia malayi intermediate filament protein 0.0056 0.0016 0.0008
Echinococcus granulosus glycogen phosphorylase 0.0342 0.0274 0.0274
Onchocerca volvulus 0.0137 0.0088 0.0105
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0181 0.0128 0.0504
Loa Loa (eye worm) hypothetical protein 0.0739 0.0632 0.0625
Loa Loa (eye worm) hypothetical protein 0.0089 0.0046 0.0038
Loa Loa (eye worm) hypothetical protein 0.0129 0.0081 0.0074
Loa Loa (eye worm) alpha-L-fucosidase 0.6015 0.5394 0.539
Echinococcus multilocularis non lysosomal glucosylceramidase 0.1095 0.0953 0.0953

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM In vitro inhibitory activity against mammary carcinoma MCF-7 cell lines ChEMBL. 8765521
IC50 (functional) > 10 uM In vitro inhibitory activity against mammary carcinoma MCF-7 cell lines ChEMBL. 8765521

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8765521

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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