TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 477.463 | Formula: C25H21F2N5O3
H donors: 3 H acceptors: 4 LogP: 3.64 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1F)C(=O)Nc1cccc(c1)C(Nc1ncnc2c1cc(F)cc2C(=O)N)C
InChi: 1S/C25H21F2N5O3/c1-13(31-24-19-11-16(26)10-18(23(28)33)22(19)29-12-30-24)14-4-3-5-17(8-14)32-25(34)15-6-7-21(35-2)20(27)9-15/h3-13H,1-2H3,(H2,28,33)(H,32,34)(H,29,30,31)
InChiKey: YOGFDHJWPOMSHT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aurora kinase A	Starlite/ChEMBL	No references
Homo sapiens	ribosomal protein S6 kinase, 70kDa, polypeptide 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K04456 RAC serine/threonine-protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	kinase Akt/PKB-related	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	AGC kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K07390 monothiol glutaredoxin, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine threonine protein kinase nrc	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08792 serum/glucocorticoid regulated kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase 2, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Sodium/potassium-transporting ATPase subunit beta-1, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	rac serine-threonine kinase, putative,protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	Protein kinase B	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Giardia lamblia	Kinase, AGC PKA	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	rac-beta serine/threonine protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus granulosus	nervana 2	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	RAC-beta serine/threonine protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126635	All targets in OG5_126635
Loa Loa (eye worm)	AGC/AKT protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	p70 ribosomal S6 kinase beta	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma cruzi	rac serine-threonine kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	Glutaredoxin protein 5	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	rac serine:threonine kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126635	All targets in OG5_126635
Candida albicans	likely protein kinase similar to S. cerevisiae YPK2 (YMR104C)	Get druggable targets OG5_126635	All targets in OG5_126635
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine-protein kinase	Get druggable targets OG5_126635	All targets in OG5_126635

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	regulator of G protein signaling	0.0014	0.0007	0.0013
Onchocerca volvulus		0.0059	0.0108	0.0476
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.0108	0.0108
Brugia malayi	serine/threonine kinase 12	0.0068	0.0128	0.0326
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0048	0.0087
Brugia malayi	GnHR receptor homolog	0.0059	0.0108	0.0274
Trichomonas vaginalis	phosphofructokinase, putative	0.0021	0.0023	0.0663
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0059	0.0108	0.0476
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.0074	0.0141	0.9664
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0059	0.0108	0.0108
Trichomonas vaginalis	AGC family protein kinase	0.0018	0.0017	0.0477
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0128	0.3682
Entamoeba histolytica	hypothetical protein	0.0014	0.0007	0.0145
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0052	0.3331
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0059	0.0108	0.0108
Trichomonas vaginalis	glucosylceramidase, putative	0.0111	0.0221	0.6339
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0147	0.03	0.0756
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Echinococcus granulosus	lamin dm0	0.0018	0.0016	0.0016
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0015	0.001	0.0562
Echinococcus multilocularis	leucyl aminopeptidase	0.0015	0.001	0.001
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0018	0.0017	0.0035
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0015	0.001	0.0026
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0014	0.0007	0.0007
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0007	0.0208
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0014	0.0009	0.0024
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0021	0.0023	0.0663
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0051	0.0089	0.0219
Trypanosoma brucei	aurora B kinase	0.0068	0.0128	0.8772
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0059	0.0108	0.0267
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.0108	0.0108
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	hypothetical protein	0.0059	0.0108	0.0194
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0108	0.0194
Brugia malayi	Hr1 repeat family protein	0.0018	0.0017	0.0042
Echinococcus multilocularis	lamin	0.0018	0.0016	0.0016
Plasmodium vivax	SET domain protein, putative	0.0021	0.0024	0.1687
Leishmania major	trypanothione reductase	0.0029	0.0042	0.2348
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Loa Loa (eye worm)	flap endonuclease-1	0.0018	0.0018	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0007	0.0208
Trichomonas vaginalis	chromobox protein, putative	0.0054	0.0097	0.2787
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Schistosoma mansoni	chromobox protein	0.0054	0.0097	0.0175
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0018	0.0017	0.0035
Trichomonas vaginalis	penicillin-binding protein, putative	0.0028	0.0039	0.1128
Brugia malayi	hypothetical protein	0.0086	0.0166	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0059	0.0108	0.0108
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0067	0.0125	0.0319
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0348	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0032
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.0074	0.0141	0.782
Echinococcus multilocularis	regulator of G protein signaling	0.0014	0.0007	0.0007
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0059	0.0108	0.0194
Trichomonas vaginalis	phosphofructokinase, putative	0.0077	0.0146	0.4197
Entamoeba histolytica	protein kinase, putative	0.0051	0.0089	0.5959
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0059	0.0108	0.0108
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.0108	0.0108
Mycobacterium ulcerans	DNA polymerase IV	0.0013	0.0005	0.0013
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.0128	0.0326
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Trichomonas vaginalis	phosphofructokinase, putative	0.0021	0.0023	0.0663
Trichomonas vaginalis	glucosylceramidase, putative	0.0111	0.0221	0.6339
Loa Loa (eye worm)	6-phosphofructokinase	0.0077	0.0146	0.0364
Leishmania major	hypothetical protein, conserved	0.0028	0.0039	0.2175
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0011	0.0002	0.0004
Mycobacterium tuberculosis	Probable oxidoreductase	0.0075	0.0142	0.0361
Mycobacterium leprae	probable zinc metalloprotease	0.18	0.3933	1
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0128	0.8727
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0017	0.0042
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.003
Brugia malayi	Protein kinase domain containing protein	0.0018	0.0017	0.0042
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0059	0.0108	0.0267
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0034	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.0108	0.0108
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0033	0.005	0.005
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0039	0.2781
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	serine threonine protein kinase nrc	0.0034	0.0052	0.0052
Schistosoma mansoni	bromodomain containing protein	0.0041	0.0068	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0063	0.0063
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0013	0.0005	0.0013
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0059	0.0108	0.0108
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0092	0.018	0.018
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.0108	0.0267
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0013	0.0005	0.0005
Brugia malayi	Melatonin receptor type 1A	0.0059	0.0108	0.0274
Trichomonas vaginalis	flap endonuclease-1, putative	0.0018	0.0018	0.0515
Toxoplasma gondii	ABC1 family protein	0.0028	0.0039	0.01
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0438	0.0941	0.1697
Entamoeba histolytica	Flap nuclease, putative	0.0018	0.0018	0.0901
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0028	0.0039	0.0071
Mycobacterium tuberculosis	Conserved protein	0.0028	0.0039	0.01
Brugia malayi	Bromodomain containing protein	0.0049	0.0085	0.0216
Schistosoma mansoni	serine/threonine-protein kinase	0.0034	0.0052	0.0094
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0059	0.0108	0.0274
Brugia malayi	ImpB/MucB/SamB family protein	0.0013	0.0005	0.0013
Echinococcus granulosus	chromobox protein 1	0.0054	0.0097	0.0097
Brugia malayi	Pre-SET motif family protein	0.0021	0.0024	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0093
Mycobacterium tuberculosis	Possible exported protein	0.1485	0.3242	0.8244
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0028	0.0039	0.01
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0089	0.2562
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0059	0.0108	0.0108
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.0108	0.0108
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0089	0.2562
Brugia malayi	Peptidase family M13 containing protein	0.18	0.3933	1
Onchocerca volvulus		0.0024	0.003	0.0072
Leishmania major	ATP-dependent phosphofructokinase	0.0077	0.0146	0.8092
Loa Loa (eye worm)	peptidase family M13 containing protein	0.133	0.2901	0.7373
Schistosoma mansoni	amine GPCR	0.0059	0.0108	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.18	0.3933	1
Echinococcus granulosus	flap endonuclease 1	0.0018	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	protein kinase c epsilon type	0.0018	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.133	0.2901	0.7373
Echinococcus granulosus	serine:threonine protein kinase N2	0.0018	0.0017	0.0017
Echinococcus multilocularis	sex peptide receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	heterochromatin protein 1	0.0054	0.0097	0.0239
Echinococcus granulosus	axis inhibition protein axin	0.0014	0.0007	0.0007
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0009	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0018	0.0017	0.0017
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.0074	0.0141	0.0262
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0029	0.0042	0.0108
Toxoplasma gondii	peptidase family M13 protein	0.18	0.3933	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0014	0.0007	0.0013
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.133	0.2901	0.7373
Schistosoma mansoni	hypothetical protein	0.0059	0.0108	0.0194
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0015	0.001	0.0694
Schistosoma mansoni	hypothetical protein	0.047	0.101	0.1821
Entamoeba histolytica	protein kinase, putative	0.0068	0.0128	0.8727
Loa Loa (eye worm)	hypothetical protein	0.0024	0.003	0.0069
Mycobacterium tuberculosis	Conserved protein	0.0028	0.0039	0.01
Echinococcus granulosus	leucine aminopeptidase protein	0.0074	0.0141	0.0141
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.0074	0.0141	1
Echinococcus multilocularis	chromobox protein 1	0.0054	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0033	0.0076
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0009	0.0017
Entamoeba histolytica	protein kinase, putative	0.0051	0.0089	0.5959
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.003
Brugia malayi	follicle stimulating hormone receptor	0.0059	0.0108	0.0274
Plasmodium falciparum	thioredoxin reductase	0.0029	0.0042	0.3002
Echinococcus multilocularis	lamin dm0	0.0018	0.0016	0.0016
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0014	0.0007	0.0018
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0013	0.0005	0.015
Schistosoma mansoni	axis inhibition protein axin	0.0014	0.0007	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.003
Loa Loa (eye worm)	glutathione reductase	0.0029	0.0042	0.01
Brugia malayi	G-protein coupled receptor	0.0059	0.0108	0.0274
Loa Loa (eye worm)	peptidase family M13 containing protein	0.133	0.2901	0.7373
Onchocerca volvulus		0.003	0.0043	0.0141
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0034	0.0052	0.3569
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0092	0.018	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Brugia malayi	ORL1-like opioid receptor	0.0059	0.0108	0.0274
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.1361	0.297	0.7548
Echinococcus multilocularis	rac serine:threonine kinase	0.0034	0.0052	0.0052
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0067	0.0125	0.0319
Brugia malayi	PXA domain containing protein	0.0014	0.0007	0.0018
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0059	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0007	0.0208
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Mycobacterium ulcerans	lipase LipD	0.0028	0.0039	0.01
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0028	0.0039	0.01
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0018	0.0017	0.0017
Echinococcus granulosus	6 phosphofructokinase	0.0077	0.0146	0.0146
Echinococcus multilocularis	protein kinase c iota type	0.0018	0.0017	0.0017
Schistosoma mansoni	endothelin-converting enzyme-related	0.0438	0.0941	0.1697
Echinococcus granulosus	7TM GPCR rhodopsin	0.0059	0.0108	0.0108
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0021	0.0023	0.1267
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0021	0.0023	0.1634
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0007	0.0208
Loa Loa (eye worm)	hypothetical protein	0.18	0.3933	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0028	0.0039	0.2687
Brugia malayi	Dopamine receptor protein 2	0.0059	0.0108	0.0274
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0059	0.0108	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus granulosus	Glutaredoxin protein 5	0.0033	0.0051	0.0051
Echinococcus multilocularis	regulator of G protein signaling 7	0.0014	0.0007	0.0007
Brugia malayi	beta-lactamase family protein	0.0028	0.0039	0.01
Echinococcus granulosus	aurora kinase A	0.0068	0.0128	0.0128
Mycobacterium ulcerans	zinc metalloprotease	0.18	0.3933	1
Schistosoma mansoni	hypothetical protein	0.047	0.101	0.1821
Brugia malayi	Heterochromatin protein 1	0.0054	0.0097	0.0246
Trichomonas vaginalis	D-aminoacylase, putative	0.0028	0.0039	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Leishmania major	DNA polymerase eta, putative	0.0013	0.0005	0.0289
Brugia malayi	regulator of G-protein signaling rgs-7	0.0014	0.0007	0.0018
Mycobacterium tuberculosis	Probable hydrolase	0.0028	0.0039	0.01
Echinococcus granulosus	regulator of G protein signaling 3	0.0014	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0016	0.0034
Toxoplasma gondii	thioredoxin reductase	0.0029	0.0042	0.0108
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0044	0.1278
Echinococcus multilocularis	nervana 2	0.0033	0.005	0.005
Echinococcus granulosus	7tm_1 domain containing protein	0.0059	0.0108	0.0108
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0015	0.001	0.0694
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0089	0.2562
Mycobacterium tuberculosis	Probable lipase LipE	0.0028	0.0039	0.01
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0043	0.0078
Schistosoma mansoni	amine GPCR	0.0059	0.0108	0.0194
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0013	0.0005	0.0009
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0005	0.0357
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0021	0.0024	0.0061
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0005	0.0006
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus multilocularis	orexin receptor type 2	0.0059	0.0108	0.0108
Loa Loa (eye worm)	PHD-finger family protein	0.0013	0.0007	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Echinococcus multilocularis	regulator of G protein signaling 7	0.0014	0.0007	0.0007
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0077	0.0146	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Schistosoma mansoni	regulator of G protein signaling	0.0014	0.0007	0.0013
Trichomonas vaginalis	D-aminoacylase, putative	0.0028	0.0039	0.1128
Echinococcus granulosus	leucyl aminopeptidase	0.0015	0.001	0.001
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.0108	0.0108
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.0074	0.0141	0.9664
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.0128	0.8727
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0179	0.0372	0.0945
Loa Loa (eye worm)	hypothetical protein	0.133	0.2901	0.7373
Echinococcus multilocularis	thioredoxin glutathione reductase	0.003	0.0043	0.0043
Echinococcus multilocularis	neuropeptide s receptor	0.0059	0.0108	0.0108
Entamoeba histolytica	protein kinase, putative	0.0051	0.0089	0.5959
Brugia malayi	cytosol aminopeptidase	0.0015	0.001	0.0026
Onchocerca volvulus	Glucosylceramidase homolog	0.0111	0.0221	0.1064
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0021	0.0023	0.0059
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0438	0.0941	0.1697
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0089	0.2562
Echinococcus granulosus	nervana 2	0.0033	0.005	0.005
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.0128	0.0326
Brugia malayi	putative neuropeptide receptor	0.0059	0.0108	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Onchocerca volvulus		0.0059	0.0108	0.0476
Schistosoma mansoni	hypothetical protein	0.047	0.101	0.1821
Brugia malayi	putative neuropeptide receptor NPR1	0.0059	0.0108	0.0274
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Brugia malayi	6-phosphofructokinase	0.0077	0.0146	0.0371
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0014	0.0009	0.0016
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0018	0.0017	0.0017
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.0128	0.9077
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0075	0.0142	0.0264
Schistosoma mansoni	hypothetical protein	0.0132	0.0268	0.0483
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0011	0.0002	0.0002
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.0108	0.0108
Toxoplasma gondii	6-phosphofructokinase	0.0021	0.0023	0.0059
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.005	0.1424
Loa Loa (eye worm)	phosphofructokinase	0.0077	0.0146	0.0364
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0075	0.0142	0.0361
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.0128	0.8727
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0059	0.0108	0.0274
Echinococcus granulosus	thioredoxin glutathione reductase	0.003	0.0043	0.0043
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0059	0.0108	0.0274
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0059	0.0108	0.0108
Onchocerca volvulus		0.0028	0.0039	0.012
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus granulosus	neuropeptide FF receptor 2	0.0059	0.0108	0.0108
Schistosoma mansoni	axis inhibition protein axin	0.0014	0.0007	0.0013
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Mycobacterium tuberculosis	Conserved protein	0.0028	0.0039	0.01
Schistosoma mansoni	6-phosphofructokinase	0.0077	0.0146	0.0263
Trichomonas vaginalis	phosphofructokinase, putative	0.0077	0.0146	0.4197
Brugia malayi	Serotonin receptor	0.0059	0.0108	0.0274
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0059	0.0108	0.0194
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0018	0.0017	0.0017
Echinococcus granulosus	geminin	0.0132	0.0268	0.0268
Echinococcus granulosus	intermediate filament protein	0.0018	0.0016	0.0016
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0021	0.0023	0.18
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0059	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0007	0.0208
Echinococcus granulosus	nervana 2	0.0033	0.005	0.005
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0033	0.005	0.0174
Brugia malayi	Intermediate filament tail domain containing protein	0.0018	0.0016	0.0041
Loa Loa (eye worm)	hypothetical protein	0.1361	0.297	0.7548
Echinococcus granulosus	g-protein coupled receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0093
Plasmodium falciparum	flap endonuclease 1	0.0018	0.0018	0.1268
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0089	0.2562
Trichomonas vaginalis	AGC family protein kinase	0.0018	0.0017	0.0477
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0168	0.0348	0.0884
Trichomonas vaginalis	phosphofructokinase, putative	0.0021	0.0023	0.0663
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0059	0.0108	0.0194
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0021	0.0023	0.1634
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0059	0.0108	0.0274
Echinococcus multilocularis	axis inhibition protein axin	0.0014	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.003	0.0044	0.0106
Schistosoma mansoni	PwLAP aminopeptidase (M17 family)	0.0015	0.001	0.0018
Plasmodium vivax	6-phosphofructokinase, putative	0.0021	0.0023	0.1634
Brugia malayi	Angiotensin-converting enzyme family protein	0.0437	0.0938	0.2386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0007	0.0208
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0108	0.0194
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0089	0.2562
Brugia malayi	Aminopeptidase ZK353.6 in chromosome III	0.0015	0.001	0.0026
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0018	0.0016	0.0034
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0015	0.001	0.0562
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17	0.0015	0.001	0.0694
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0128	0.3682
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0108	0.0194
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.0108	0.0267
Entamoeba histolytica	protein kinase , putative	0.0068	0.0128	0.8727
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0034	0.0052	0.0052
Mycobacterium ulcerans	DNA polymerase IV	0.0013	0.0005	0.0013
Brugia malayi	ImpB/MucB/SamB family protein	0.0013	0.0005	0.0013
Brugia malayi	Thioredoxin reductase	0.0029	0.0042	0.0108
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0034	0.0052	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0091
Echinococcus granulosus	leucyl aminopeptidase	0.0015	0.001	0.001
Echinococcus multilocularis	dna polymerase eta	0.0013	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0013	0.0007	0.0013
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	regulator of G protein signaling 3	0.0014	0.0007	0.0007
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0018	0.0017	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.0108	0.0108
Echinococcus granulosus	allatostatin A receptor	0.0059	0.0108	0.0108
Mycobacterium ulcerans	beta-lactamase	0.0028	0.0039	0.01
Mycobacterium tuberculosis	Probable reductase	0.0067	0.0125	0.0319
Echinococcus multilocularis	6 phosphofructokinase	0.0077	0.0146	0.0146
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0048	0.0048
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0077	0.0146	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0059	0.0108	0.0108
Schistosoma mansoni	z-protein (S1r protein)	0.0014	0.0007	0.0013
Schistosoma mansoni	6-phosphofructokinase	0.0077	0.0146	0.0263
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0108	0.0108
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Schistosoma mansoni	amine GPCR	0.0059	0.0108	0.0194
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0059	0.0108	0.0194
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0028	0.0039	0.01
Trichomonas vaginalis	phosphofructokinase, putative	0.0021	0.0023	0.0663
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0348	1
Brugia malayi	neuropeptide F receptor	0.0059	0.0108	0.0274
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Echinococcus multilocularis	neuropeptide receptor A26	0.0059	0.0108	0.0108
Leishmania major	DNA polymerase kappa, putative	0.0013	0.0005	0.0289
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0063	0.0063
Echinococcus granulosus	lamin	0.0018	0.0016	0.0016
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0018	0.0017	0.0017
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.0108	0.0108
Echinococcus granulosus	fetal alzheimer antigen falz	0.0015	0.001	0.001
Schistosoma mansoni	opsin-like receptor	0.0059	0.0108	0.0194
Schistosoma mansoni	regulator of G protein signaling	0.0014	0.0007	0.0013
Leishmania major	protein kinase, putative	0.0068	0.0128	0.7099
Loa Loa (eye worm)	intermediate filament protein	0.0018	0.0016	0.0034
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0028	0.0039	0.0093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus granulosus	Protein kinase C brain isozyme	0.0018	0.0017	0.0017
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0077	0.0146	0.0371
Schistosoma mansoni	hypothetical protein	0.047	0.101	0.1821
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Echinococcus multilocularis	leucyl aminopeptidase	0.0015	0.001	0.001
Echinococcus granulosus	sodium channel protein	0.0092	0.018	0.018
Trypanosoma cruzi	DNA polymerase eta, putative	0.0013	0.0005	0.0357
Trichomonas vaginalis	esterase, putative	0.0028	0.0039	0.1128
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0461	0.099	0.1785
Plasmodium falciparum	glutathione reductase	0.0029	0.0042	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0005	0.0357
Loa Loa (eye worm)	aminopeptidase in chromosome V	0.0015	0.001	0.0018
Toxoplasma gondii	AGC kinase	0.0051	0.0089	0.0227
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0059	0.0108	0.0108
Trypanosoma cruzi	hypothetical protein, conserved	0.0028	0.0039	0.2687
Echinococcus multilocularis	somatostatin receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	zinc finger protein	0.0013	0.0006	0.001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0348	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus granulosus	protein kinase c epsilon type	0.0018	0.0017	0.0017
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0015	0.001	0.0018
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0051	0.0089	0.0219
Schistosoma mansoni	hypothetical protein	0.0132	0.0268	0.0483
Schistosoma mansoni	flap endonuclease-1	0.0017	0.0014	0.0025
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0048	0.0048
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0018	0.0018	0.0992
Echinococcus granulosus	ankyrin repeat domain containing protein 17	0.0015	0.001	0.001
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	hypothetical protein	0.0059	0.0108	0.0108
Schistosoma mansoni	chromobox protein	0.0054	0.0097	0.0175
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0014	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	aurora kinase A	0.0068	0.0128	0.0128
Mycobacterium ulcerans	6-phosphofructokinase	0.0077	0.0146	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0224	0.0469	0.1187
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0034	0.0052	0.3693
Echinococcus granulosus	biogenic amine 5HT receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	regulator of G protein signaling	0.0014	0.0007	0.0013
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0908	0.1973	0.3559
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Trichomonas vaginalis	glucosylceramidase, putative	0.0111	0.0221	0.6339
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0023	0.0029	0.0029
Trypanosoma brucei	trypanothione reductase	0.0029	0.0042	0.2901
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus granulosus	neuropeptide receptor	0.0059	0.0108	0.0108
Trypanosoma brucei	hypothetical protein, conserved	0.0028	0.0039	0.2687
Trichomonas vaginalis	glucosylceramidase, putative	0.0111	0.0221	0.6339
Loa Loa (eye worm)	hypothetical protein	0.0892	0.1937	0.4922
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0014	0.0009	0.0009
Echinococcus granulosus	neuropeptide receptor A26	0.0059	0.0108	0.0108
Brugia malayi	neuropeptide F receptor	0.0059	0.0108	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0079	0.0194
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0013	0.0005	0.0013
Schistosoma mansoni	amine GPCR	0.0059	0.0108	0.0194
Brugia malayi	larval opioid receptor	0.0059	0.0108	0.0274
Echinococcus multilocularis	nervana 2	0.0033	0.005	0.005
Echinococcus multilocularis	endothelin converting enzyme 1	0.18	0.3933	0.3933
Loa Loa (eye worm)	aminopeptidase in chromosome III	0.0015	0.001	0.0018
Schistosoma mansoni	serine/threonine kinase	0.0018	0.0017	0.003
Loa Loa (eye worm)	hypothetical protein	0.133	0.2901	0.7373
Schistosoma mansoni	hypothetical protein	0.0059	0.0108	0.0194
Brugia malayi	intermediate filament protein	0.0018	0.0016	0.0041
Echinococcus multilocularis	dna polymerase kappa	0.0013	0.0005	0.0005
Echinococcus multilocularis	musashi	0.0018	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.18	0.3933	1
Trypanosoma brucei	aminopeptidase, putative	0.0015	0.001	0.0694
Entamoeba histolytica	protein kinase, putative	0.0068	0.0128	0.8727
Echinococcus granulosus	endothelin converting enzyme 1	0.18	0.3933	0.3933
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0059	0.0108	0.0108
Brugia malayi	glutathione reductase	0.0029	0.0042	0.0108
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0075	0.0142	0.0361
Brugia malayi	phosphofructokinase	0.0077	0.0146	0.0371
Echinococcus granulosus	beta LACTamase domain containing family member	0.0028	0.0039	0.0039
Brugia malayi	Dopamine receptor protein 1	0.0059	0.0108	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0093
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0108	0.0194
Brugia malayi	Aminopeptidase W07G4.4 in chromosome V	0.0015	0.001	0.0026
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0018	0.0017	0.0017
Trypanosoma cruzi	trypanothione reductase, putative	0.0029	0.0042	0.2901
Trichomonas vaginalis	phosphofructokinase, putative	0.0077	0.0146	0.4197
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0034	0.0052	0.3569
Onchocerca volvulus		0.0059	0.0108	0.0476
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0025	0.0716
Toxoplasma gondii	aurora kinase	0.0068	0.0128	0.0326
Brugia malayi	Serotonin receptor	0.0059	0.0108	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0093
Schistosoma mansoni	adenoreceptor	0.0059	0.0108	0.0194
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0108	0.0194
Loa Loa (eye worm)	PXA domain-containing protein	0.0014	0.0007	0.0011
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Entamoeba histolytica	hypothetical protein	0.0014	0.0007	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0048	0.0115
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.003
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0014	0.0007	0.0013
Echinococcus multilocularis	sodium channel protein	0.0092	0.018	0.018
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0028	0.0039	0.01
Mycobacterium tuberculosis	Probable lipase LipD	0.0028	0.0039	0.01
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Brugia malayi	beta-lactamase family protein	0.0028	0.0039	0.01
Giardia lamblia	Kinase, AGC PKA	0.0034	0.0052	0.4069
Trichomonas vaginalis	AGC family protein kinase	0.0018	0.0017	0.0477
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0014	0.0007	0.0011
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0015	0.001	0.0694
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0052	0.3331
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.0108	0.0194
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0018	0.0017	0.0017
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0039	0.01
Onchocerca volvulus		0.0028	0.0039	0.012
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0018	0.0018	0.1226
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.2533	0.5545	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0059	0.0108	0.0267
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0128	0.0319
Schistosoma mansoni	atypical protein kinase C	0.0018	0.0017	0.003
Schistosoma mansoni	serine/threonine-protein kinase	0.0034	0.0053	0.0096
Echinococcus granulosus	Regulator of G protein signaling 20	0.0014	0.0007	0.0007
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.0108	0.0108
Trypanosoma brucei	DNA polymerase eta, putative	0.0013	0.0005	0.0357
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0128	0.3682
Schistosoma mansoni	myosin xvIII	0.0059	0.0108	0.0194
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0018	0.0017	0.0017
Echinococcus granulosus	neuropeptide s receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0018	0.0017	0.0035
Schistosoma mansoni	hypothetical protein	0.0059	0.0108	0.0194
Brugia malayi	Dopamine receptor	0.0059	0.0108	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.0108	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0077	0.0146	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Plasmodium vivax	flap endonuclease 1, putative	0.0018	0.0018	0.1268
Schistosoma mansoni	growth hormone secretagogue receptor	0.0059	0.0108	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0011
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0908	0.1973	0.3559
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0044	0.1278
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0908	0.1973	0.3559
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus granulosus	serine/threonine protein kinase	0.0034	0.0052	0.0052
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.0074	0.0141	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0028	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Onchocerca volvulus		0.0059	0.0108	0.0476
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0128	0.0319
Trypanosoma cruzi	Protein kinase B	0.0034	0.0052	0.3569
Plasmodium vivax	glutathione reductase, putative	0.0029	0.0042	0.3002
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0014	0.0007	0.0007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	dna polymerase kappa	0.0013	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.18	0.3933	1
Giardia lamblia	Aurora kinase	0.0068	0.0128	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0014	0.0007	0.0007
Loa Loa (eye worm)	TYRA-2 protein	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Brugia malayi	sulfakinin receptor protein	0.0059	0.0108	0.0274
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0059	0.0108	0.0194
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.0128	0.8772
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0018	0.0017	0.0035
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0014	0.0007	0.0018
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.047	0.101	0.1821
Echinococcus multilocularis	Glutaredoxin protein 5	0.0033	0.0051	0.0051
Schistosoma mansoni	neprilysin	0.047	0.101	0.1821
Brugia malayi	protein kinase C II.	0.0018	0.0017	0.0042
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0051	0.0089	0.6103
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0348	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.0108	0.0267
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0067	0.0125	0.0319
Trichomonas vaginalis	phosphofructokinase, putative	0.0021	0.0023	0.0663
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0059	0.0108	0.0194
Schistosoma mansoni	neuropeptide f receptor 76f	0.0059	0.0108	0.0194
Onchocerca volvulus		0.0059	0.0108	0.0476
Entamoeba histolytica	hypothetical protein	0.0014	0.0007	0.0145
Schistosoma mansoni	opsin-like receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.0128	0.0128
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.0108	0.0108
Plasmodium vivax	6-phosphofructokinase, putative	0.0021	0.0023	0.1634
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0011	0.0002	0.0004
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0018	0.0017	0.0017
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.18	0.3933	0.7092
Onchocerca volvulus		0.0892	0.1937	1
Plasmodium vivax	thioredoxin reductase, putative	0.0029	0.0042	0.3002
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.0108	0.0194
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0059	0.0108	0.0108
Brugia malayi	peptidase family M13 containing protein	0.0438	0.0941	0.2393
Brugia malayi	PXA domain containing protein	0.0014	0.0007	0.0018
Schistosoma mansoni	opsin-like receptor	0.0059	0.0108	0.0194
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0014	0.0007	0.0007
Brugia malayi	A-kinase anchor protein 10, precursor	0.0014	0.0007	0.0018
Echinococcus granulosus	fmrfamide receptor	0.0059	0.0108	0.0108
Entamoeba histolytica	protein kinase 2, putative	0.0034	0.0052	0.3331
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0438	0.0941	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0018	0.0017	0.0017
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus granulosus	biogenic amine 5HT receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.003
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.0128	0.0128
Toxoplasma gondii	leucyl aminopeptidase LAP	0.0074	0.0141	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0108	0.0108
Toxoplasma gondii	phosphofructokinase PFKII	0.0021	0.0023	0.0059
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0036	0.0084
Loa Loa (eye worm)	hypothetical protein	0.1361	0.297	0.7548
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0011	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0014	0.0007	0.0018
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0348	1
Giardia lamblia	Flap structure-specific endonuclease	0.0018	0.0018	0.1397
Loa Loa (eye worm)	melatonin receptor type 1A	0.0059	0.0108	0.0267
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus multilocularis	leucyl aminopeptidase	0.0015	0.001	0.001
Echinococcus multilocularis	chromobox protein 1	0.0054	0.0097	0.0097
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0028	0.0039	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0025	0.0716
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0018	0.0018	0.0046
Trichomonas vaginalis	set domain proteins, putative	0.0167	0.0345	0.9909
Echinococcus granulosus	protein kinase C gamma type	0.0018	0.0017	0.0017
Echinococcus multilocularis	allatostatin A receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0018	0.0017	0.0035
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0108	0.0108
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0059	0.0108	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Trichomonas vaginalis	AGC family protein kinase	0.0018	0.0017	0.0477
Trichomonas vaginalis	penicillin-binding protein, putative	0.0028	0.0039	0.1128
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0128	0.0319
Echinococcus multilocularis	leucine aminopeptidase protein	0.0074	0.0141	0.0141
Echinococcus granulosus	regulator of G protein signaling 7	0.0014	0.0007	0.0007
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.003	0.0044	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.0108	0.0194
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0021	0.0024	0.0024
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0437	0.0938	0.238
Schistosoma mansoni	DNA polymerase eta	0.0013	0.0005	0.0009
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0021	0.0023	0.1579
Trichomonas vaginalis	glucosylceramidase, putative	0.0111	0.0221	0.6339
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Echinococcus multilocularis	g-protein coupled receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	sex peptide receptor	0.0059	0.0108	0.0108
Echinococcus granulosus	axis inhibition protein axin	0.0014	0.0007	0.0007
Echinococcus granulosus	serotonin receptor	0.0059	0.0108	0.0108
Mycobacterium ulcerans	esterase/lipase LipP	0.0028	0.0039	0.01
Brugia malayi	RE15519p	0.0059	0.0108	0.0274
Brugia malayi	regulator of G-protein signaling egl-10	0.0014	0.0007	0.0018
Schistosoma mansoni	intermediate filament proteins	0.0018	0.0016	0.0029
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0067	0.0125	0.0221
Echinococcus granulosus	dro:myosuppressin receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0908	0.1973	0.3559
Loa Loa (eye worm)	thioredoxin reductase	0.0029	0.0042	0.01
Loa Loa (eye worm)	RGS-3 protein	0.0014	0.0007	0.0011
Echinococcus granulosus	dna polymerase eta	0.0013	0.0005	0.0005
Brugia malayi	beta-lactamase	0.0028	0.0039	0.01
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0089	0.0227
Echinococcus multilocularis	serotonin receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Giardia lamblia	DINP protein human, muc B family	0.0013	0.0005	0.0407
Brugia malayi	Bromodomain containing protein	0.0025	0.0032	0.0083
Trichomonas vaginalis	D-aminoacylase, putative	0.0028	0.0039	0.1128
Echinococcus multilocularis	serotonin receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	protein kinase	0.0068	0.0128	0.0231
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.0128	0.8727
Brugia malayi	AKH receptor	0.0059	0.0108	0.0274
Schistosoma mansoni	amine GPCR	0.0059	0.0108	0.0194
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.456	1	1
Loa Loa (eye worm)	hypothetical protein	0.1361	0.297	0.7548
Trichomonas vaginalis	glucosylceramidase, putative	0.0111	0.0221	0.6339
Trypanosoma brucei	unspecified product	0.0013	0.0005	0.0357
Entamoeba histolytica	phosphofructokinase, putative	0.0077	0.0146	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0077	0.0146	0.0364
Onchocerca volvulus		0.0167	0.0345	0.171
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Trichomonas vaginalis	glucosylceramidase, putative	0.0111	0.0221	0.6339
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0128	0.3682
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0013	0.0005	0.0357
Chlamydia trachomatis	cytosol aminopeptidase	0.0074	0.0141	1
Echinococcus granulosus	expressed protein	0.0263	0.0556	0.0556
Mycobacterium tuberculosis	Probable dehydrogenase	0.0067	0.0125	0.0319
Loa Loa (eye worm)	beta-lactamase	0.0028	0.0039	0.0093
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0023	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus multilocularis	expressed protein	0.0263	0.0556	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0011
Loa Loa (eye worm)	hypothetical protein	0.1361	0.297	0.7548
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.0128	0.9077
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0059	0.0108	0.0194
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0059	0.0108	0.0274
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0128	0.0231
Onchocerca volvulus		0.0059	0.0108	0.0476
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.0108	0.0267
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.18	0.3933	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0089	0.2562
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0013	0.0005	0.0289
Brugia malayi	Flap endonuclease-1	0.0018	0.0018	0.0046
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0908	0.1973	0.3559
Echinococcus granulosus	zinc finger protein	0.0013	0.0006	0.0006
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.0074	0.0141	0.9664
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0059	0.0108	0.0108
Schistosoma mansoni	histamine h1 receptor	0.0059	0.0108	0.0194
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0093
Echinococcus granulosus	chromobox protein 1	0.0054	0.0097	0.0097
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0438	0.0941	0.2387
Trichomonas vaginalis	DNA polymerase eta, putative	0.0013	0.0005	0.015
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.0074	0.0141	0.0359
Entamoeba histolytica	phosphofructokinase, putative	0.0077	0.0146	1
Brugia malayi	6-phosphofructokinase	0.0077	0.0146	0.0371
Entamoeba histolytica	phosphofructokinase, putative	0.0077	0.0146	1
Echinococcus multilocularis	zinc finger protein	0.0013	0.0006	0.0006
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0438	0.0941	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Brugia malayi	hypothetical protein	0.0014	0.0007	0.0018
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0108	0.0194
Schistosoma mansoni	regulator of G protein signaling	0.0014	0.0007	0.0013
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0077	0.0146	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0108	0.0194
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0067	0.0125	0.0319
Echinococcus granulosus	regulator of G protein signaling 7	0.0014	0.0007	0.0007
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.0108	0.0108
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Echinococcus granulosus	protein kinase c iota type	0.0018	0.0017	0.0017
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0013	0.0005	0.0005
Mycobacterium tuberculosis	Probable esterase LipL	0.0028	0.0039	0.01
Trypanosoma brucei	DNA polymerase IV, putative	0.0013	0.0005	0.0357
Echinococcus multilocularis	serine threonine protein kinase	0.0018	0.0017	0.0017
Brugia malayi	chromobox protein homolog 3	0.003	0.0044	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0011
Brugia malayi	p70 ribosomal S6 kinase beta	0.0051	0.0089	0.0227
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0015	0.001	0.001
Mycobacterium ulcerans	leucyl aminopeptidase	0.0074	0.0141	0.0359
Schistosoma mansoni	lamin	0.0018	0.0016	0.0029
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0021	0.0023	0.1634
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0168	0.0348	0.0878
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0028	0.0039	0.01
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17	0.0015	0.001	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0014	0.0007	0.0013
Trichomonas vaginalis	phosphofructokinase, putative	0.0021	0.0023	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Onchocerca volvulus		0.0028	0.0039	0.012
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.005	0.1424
Echinococcus granulosus	neuropeptide receptor	0.0059	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Echinococcus granulosus	NDR protein kinase	0.0018	0.0017	0.0017
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0059	0.0108	0.0108
Brugia malayi	hypothetical protein	0.0059	0.0108	0.0274
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0014	0.0009	0.0016
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.003
Trichomonas vaginalis	glucosylceramidase, putative	0.0117	0.0234	0.6715
Echinococcus granulosus	orexin receptor type 2	0.0059	0.0108	0.0108
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0438	0.0941	0.1697
Schistosoma mansoni	hypothetical protein	0.047	0.101	0.1821
Schistosoma mansoni	leucine aminopeptidase	0.0015	0.001	0.0018
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.0009	0.0017
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0018	0.0018	0.1226
Echinococcus multilocularis	flap endonuclease 1	0.0018	0.0018	0.0018
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0014	0.0007	0.0208
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0108	0.0194
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0021	0.0023	0.1634
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0108	0.0108
Echinococcus granulosus	somatostatin receptor	0.0059	0.0108	0.0108
Echinococcus multilocularis	dro:myosuppressin receptor	0.0059	0.0108	0.0108
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0024	0.0043
Loa Loa (eye worm)	hypothetical protein	0.1361	0.297	0.7548
Echinococcus multilocularis	axis inhibition protein axin	0.0014	0.0007	0.0007
Onchocerca volvulus		0.0059	0.0108	0.0476
Trichomonas vaginalis	glucosylceramidase, putative	0.0117	0.0234	0.6715
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0013	0.0005	0.0006
Echinococcus multilocularis	geminin	0.0132	0.0268	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Schistosoma mansoni	hypothetical protein	0.047	0.101	0.1821
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0108	0.0267
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0013	0.0005	0.0009
Brugia malayi	G protein-coupled receptor	0.0059	0.0108	0.0274
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0017	0.0015	0.0418
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0048	0.0087
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.002	0.0022	0.0022
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0059	0.0108	0.0476
Trichomonas vaginalis	chromobox protein, putative	0.0054	0.0097	0.2787
Brugia malayi	G-protein coupled receptor	0.0059	0.0108	0.0274
Trichomonas vaginalis	phosphofructokinase, putative	0.0077	0.0146	0.4197
Brugia malayi	G protein-coupled receptor F59B2.13	0.0059	0.0108	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0011
Onchocerca volvulus		0.0059	0.0108	0.0476
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.0108	0.0108
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0033	0.005	0.005
Schistosoma mansoni	lamin	0.0018	0.0016	0.0029
Plasmodium falciparum	M17 leucyl aminopeptidase	0.0074	0.0141	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.0108	0.0108
Brugia malayi	Pre-SET motif family protein	0.0147	0.03	0.0763
Entamoeba histolytica	protein kinase, putative	0.0018	0.0017	0.0807
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0059	0.0108	0.0194
Echinococcus granulosus	G protein coupled receptor 139	0.0059	0.0108	0.0108
Echinococcus granulosus	regulator of G protein signaling 3	0.0014	0.0007	0.0007
Trichomonas vaginalis	glucosylceramidase, putative	0.0168	0.0348	1
Brugia malayi	PHD-finger family protein	0.0016	0.0013	0.0034

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.83 nM	Enzyme Assay	BINDINGDB.	No reference
IC50 (binding)	= 230 nM	BindingDB_Patents: Enzyme Assay. P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compound plate to initiate the enzyme reaction; P70S6K (3 nM, T412E mutant, Millipore) is mixed with 24 µM ATP in an assay buffer containing 100 mM Hepes (pH 7.5), 5 mM MgCl2, 1 mM DTT, 0.015% Brij and 1 µM of the substrate peptide FITC-AHA-AKRRRLSSLRA-OH (derived from the S6 ribosomal protein sequence, FITC=fluorescein isothiocyanate, AHA=6-aminohexanoic acid). The reaction is incubated for 90 min at 25° C., before the addition of 10 mM EDTA to stop the reaction. The proportion of substrate and product (phosphorylated) peptide is analysed on a Caliper Life Sciences Lab Chip 3000, using a pressure of -1.4 psi, and upstream and downstream voltages of -3000 and -700 respectively.	ChEMBL.	No reference
IC50 (binding)	= 230 nM	BindingDB_Patents: Enzyme Assay. P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compound plate to initiate the enzyme reaction; P70S6K (3 nM, T412E mutant, Millipore) is mixed with 24 µM ATP in an assay buffer containing 100 mM Hepes (pH 7.5), 5 mM MgCl2, 1 mM DTT, 0.015% Brij and 1 µM of the substrate peptide FITC-AHA-AKRRRLSSLRA-OH (derived from the S6 ribosomal protein sequence, FITC=fluorescein isothiocyanate, AHA=6-aminohexanoic acid). The reaction is incubated for 90 min at 25° C., before the addition of 10 mM EDTA to stop the reaction. The proportion of substrate and product (phosphorylated) peptide is analysed on a Caliper Life Sciences Lab Chip 3000, using a pressure of -1.4 psi, and upstream and downstream voltages of -3000 and -700 respectively.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3685290

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1973359