Detailed information for compound 207615

Basic information

Technical information
  • TDR Targets ID: 207615
  • Name: 2-(3-cyclohexylpropyl)-5-(4-phenylphenyl)-1H- imidazole
  • MW: 344.493 | Formula: C24H28N2
  • H donors: 1 H acceptors: 1 LogP: 7.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)CCCc1[nH]cc(n1)c1ccc(cc1)c1ccccc1
  • InChi: 1S/C24H28N2/c1-3-8-19(9-4-1)10-7-13-24-25-18-23(26-24)22-16-14-21(15-17-22)20-11-5-2-6-12-20/h2,5-6,11-12,14-19H,1,3-4,7-10,13H2,(H,25,26)
  • InChiKey: PPZOEJFEHZJIHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-cyclohexylpropyl)-4-(4-phenylphenyl)-3H-imidazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Sodium channel alpha subunits; brain (Types I, II, III) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1272 0.347
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0421 0.0421
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0242 0.3443 0.8208
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0033 0.0033
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0413 0.0986
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0008 0.0055 0.0055
Brugia malayi hypothetical protein 0.0242 0.3443 0.8208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0651 0.0651
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0218 0.052
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0218 0.052
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0402 0.3157
Brugia malayi tailless protein 0.0019 0.0218 0.052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0651 0.0651
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.065 0.1548
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1272 0.347
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0218 0.0218
Schistosoma mansoni microtubule-associated protein tau 0.0697 1 1
Brugia malayi hypothetical protein 0.0068 0.0922 0.2198
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0055 0.0131
Toxoplasma gondii hypothetical protein 0.0009 0.0069 0.0767
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0402 0.3157
Trichomonas vaginalis rotamase, putative 0.0033 0.0413 0.1066
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0525 0.0525
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0525 0.0525
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0246 0.3487 0.3487
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0069 0.0163
Brugia malayi MH1 domain containing protein 0.0004 0.0007 0.0016
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0256 0.2009
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0069 0.0069
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0069 0.0163
Echinococcus multilocularis geminin 0.0165 0.2327 0.2327
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1272 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.004 0.0514 0.1225
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0033 0.0249
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0657 0.1567
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.084 0.1054
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0747 0.0747
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0651 0.0651
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1272 0.3031
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0086 0.0672
Schistosoma mansoni serine/threonine protein kinase 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0107 0.0209
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0514 0.1225
Loa Loa (eye worm) nuclear factor I 0.0004 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0002
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0402 0.2664
Onchocerca volvulus 0.004 0.0525 0.125
Loa Loa (eye worm) AGC/PKG protein kinase 0.0004 0.0003 0.0007
Leishmania major protein kinase, putative 0.0004 0.0003 0.0014
Brugia malayi RasGEF domain containing protein 0.0006 0.0033 0.0078
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0402 0.3157
Loa Loa (eye worm) hypothetical protein 0.0033 0.0421 0.1003
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0175
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0218 0.052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Entamoeba histolytica hypothetical protein 0.0011 0.0107 0.0601
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Schistosoma mansoni hypothetical protein 0.0033 0.0421 0.0421
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0525 0.0525
Schistosoma mansoni smad 0.0008 0.0058 0.0058
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0615 0.0615
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0525 0.125
Schistosoma mansoni lipoxygenase 0.0172 0.2421 0.2421
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Echinococcus multilocularis son of sevenless 1 0.0006 0.0033 0.0033
Onchocerca volvulus 0.0295 0.4195 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0514 0.8349
Echinococcus granulosus expressed protein 0.0033 0.0413 0.0413
Echinococcus granulosus cGMP dependent protein kinase 1 0.0004 0.0003 0.0003
Trypanosoma brucei polo-like protein kinase 0.0092 0.1272 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0218 0.0218
Onchocerca volvulus 0.001 0.0088 0.0206
Echinococcus multilocularis microtubule associated protein 2 0.0697 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0882 0.0882
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0058 0.0138
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0069 0.0069
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0041 0.0536 0.1278
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0525 0.1253
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0107 0.0836
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0251 0.0251
Brugia malayi hypothetical protein 0.0035 0.045 0.1072
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.065 0.065
Trichomonas vaginalis rotamase, putative 0.0032 0.0402 0.1035
Loa Loa (eye worm) steroid hormone receptor 0.0184 0.2606 0.6212
Loa Loa (eye worm) Smad1 0.0008 0.0058 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0882 0.1108
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0525 0.0525
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0058 0.0058
Schistosoma mansoni tsg101-related 0.0056 0.0758 0.0758
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.084 0.1054
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.3443 0.3443
Brugia malayi hypothetical protein 0.0295 0.4195 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1623 0.3869
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.065 0.065
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0615 0.697
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0218 0.052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0651 0.1551
Loa Loa (eye worm) hypothetical protein 0.0104 0.1452 0.3461
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0405 0.0405
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0525 0.0525
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0525 0.125
Onchocerca volvulus 0.0032 0.0405 0.0963
Brugia malayi RasGEF domain containing protein 0.0006 0.0033 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0525 0.0525
Schistosoma mansoni survival motor neuron protein 0.0049 0.0657 0.0657
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0525 0.0525
Echinococcus multilocularis calcium activated potassium channel 0.0004 0.0004 0.0004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0525 0.0525
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0525 0.0525
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0218 0.0218
Echinococcus multilocularis voltage gated potassium channel 0.0008 0.0055 0.0055
Brugia malayi hypothetical protein 0.0041 0.0536 0.1278
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0251 0.0598
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1272 0.1272
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0525 0.1253
Schistosoma mansoni hypothetical protein 0.0035 0.045 0.045
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1452 0.3461
Loa Loa (eye worm) hypothetical protein 0.0068 0.0922 0.2198
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0525 0.1253
Brugia malayi ecdysteroid receptor 0.004 0.0525 0.1253
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0536 0.1278
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0525 0.0525
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0021 0.0251 0.0598
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0421 0.1003
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.065 0.065
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0882 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.065 0.065
Brugia malayi nuclear receptor NHR-88 0.0019 0.0218 0.052
Brugia malayi hypothetical protein 0.0021 0.0251 0.0598
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0615 0.1467
Schistosoma mansoni serine/threonine protein kinase 0.0004 0.0003 0.0003
Brugia malayi steroid hormone receptor 0.0184 0.2606 0.6212
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0882 0.0882
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0068 0.0922 0.0922
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0251 0.0251
Brugia malayi nuclear receptor NHR-67 0.0019 0.0218 0.052
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0068 0.0922 0.0922
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0413 0.1066
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0246 0.3487 0.3487
Brugia malayi hypothetical protein 0.0019 0.0218 0.052
Schistosoma mansoni loxhd1 0.0041 0.0536 0.0536
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0882 0.6931
Echinococcus multilocularis Smad4 0.0008 0.0058 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0525 0.0525
Entamoeba histolytica hypothetical protein 0.0035 0.045 0.3364
Loa Loa (eye worm) hypothetical protein 0.0049 0.065 0.1548
Brugia malayi hypothetical protein 0.0021 0.0251 0.0598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0651 0.0651
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0218 0.0218
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0218 0.0218
Schistosoma mansoni coup transcription factor 0.004 0.0525 0.0525
Giardia lamblia Kinase, PLK 0.0092 0.1272 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0882 0.1108
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1272 1
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0092 0.1276 0.1276
Loa Loa (eye worm) hypothetical protein 0.0004 0.0007 0.0016
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0514 0.1225
Schistosoma mansoni Smad4 0.0008 0.0058 0.0058
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0004 0.0003 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0525 0.0525
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0033 0.0033
Entamoeba histolytica hypothetical protein 0.0011 0.0107 0.0601
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0218 0.0218
Brugia malayi hypothetical protein 0.0009 0.0069 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Trypanosoma cruzi hypothetical protein 0.0006 0.0033 0.0249
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0536 0.0536
Trypanosoma cruzi hypothetical protein 0.0006 0.0033 0.0249
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0058 0.0058
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0555 0.7956 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0055 0.0055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0882 0.1108
Echinococcus granulosus GPCR family 2 0.0033 0.0421 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0107 0.0209
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0055 0.0055
Brugia malayi nuclear hormone receptor 0.004 0.0525 0.1253
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0069 0.0069
Brugia malayi Doublecortin family protein 0.0041 0.0536 0.1278
Schistosoma mansoni lipoxygenase 0.0246 0.3487 0.3487
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0033 0.0078
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0004 0.0003 0.0003
Echinococcus granulosus protoporphyrinogen oxidase 0.0004 0.0001 0.0001
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1272 0.3033
Brugia malayi MH1 domain containing protein 0.0008 0.0058 0.0138
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.065 0.065
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2725 0.2725
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0176 0.2483 0.5919
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0525 0.0525
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0033 0.0033
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.1276 0.1276
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0218 0.0218
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0388 0.0388
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0651 0.0651
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0055 0.0055
Echinococcus granulosus calcium activated potassium channel 0.0004 0.0004 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0251 0.0598
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0218 0.0218
Brugia malayi ecdysone receptor 0.0019 0.0218 0.052
Schistosoma mansoni hypothetical protein 0.0297 0.4235 0.4235
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0555 0.7956 1
Echinococcus granulosus voltage gated potassium channel 0.0008 0.0055 0.0055
Schistosoma mansoni kinase 0.0047 0.0619 0.0619
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1272 1
Brugia malayi conserved hypotetical protein 0.0019 0.0218 0.052
Schistosoma mansoni hypothetical protein 0.0049 0.0657 0.0657
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0218 0.052
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0069 0.0163
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0129 0.181 0.2274
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0055 0.0055
Brugia malayi N-terminal motif family protein 0.0006 0.0033 0.0078
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0069 0.0069
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0058 0.0138
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0055 0.0055
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0421 0.0421
Schistosoma mansoni hypothetical protein 0.0165 0.2327 0.2327
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1272 0.1272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0055 0.0055
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0069 0.0069
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.084 0.1054
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Onchocerca volvulus 0.0019 0.0218 0.0518
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0525 0.1253
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0055 0.0055
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0514 0.8349
Echinococcus multilocularis RUN 0.0041 0.0536 0.0536
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0033 0.0033
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0525 0.0525
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.0033 0.0076
Trypanosoma cruzi hypothetical protein 0.0004 0.0007 0.0043
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.3443 0.3443
Plasmodium falciparum cGMP-dependent protein kinase 0.0004 0.0003 0.0028
Schistosoma mansoni rab6-interacting 0.0041 0.0536 0.0536
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0069 0.0069
Echinococcus granulosus Protein son of sevenless 0.0006 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0071 0.0975 0.0975
Brugia malayi N-terminal motif family protein 0.0176 0.2483 0.5919
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0405 0.4585
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0405 0.0405
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.065 0.065
Brugia malayi nuclear receptor RXR 0.0021 0.0251 0.0598
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0033 0.0033
Schistosoma mansoni tsg101-related 0.0046 0.0609 0.0609
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0218 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1272 0.347
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1272 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0525 0.0525
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0006 0.0033 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0525 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1272 0.1272
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0055 0.0055
Brugia malayi Egg laying defective protein 4 0.0004 0.0003 0.0007
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0615 0.1467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0525 0.0525
Schistosoma mansoni nuclear hormone receptor 0.004 0.0525 0.0525
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0975 0.2324
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0033 0.0033
Plasmodium vivax SET domain protein, putative 0.0032 0.0405 0.6578
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0402 0.4555
Brugia malayi nuclear receptor NHR-88 0.004 0.0525 0.1253
Brugia malayi all-trans-13,14-dihydroretinol saturase 0.0004 0.0001 0.0002
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0525 0.1253
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0004 0.0003 0.0003
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0295 0.4195 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0218 0.0218
Brugia malayi MH1 domain containing protein 0.0004 0.0007 0.0016
Onchocerca volvulus 0.0019 0.0218 0.0518
Trichomonas vaginalis set domain proteins, putative 0.0254 0.3605 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0009 0.0069 0.0163
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.1272 0.1272
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0033 0.0033
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0536 0.0536
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0033 0.0078
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0008 0.0055 0.0055
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0055 0.0062
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0069 0.0069
Schistosoma mansoni smad1 5 8 and 0.0008 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Brugia malayi MH1 domain containing protein 0.0008 0.0058 0.0138
Entamoeba histolytica hypothetical protein 0.0011 0.0107 0.0601
Brugia malayi DIX domain containing protein 0.0009 0.0069 0.0163
Schistosoma mansoni tsg101-related 0.0056 0.0758 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0525 0.1253
Brugia malayi nuclear receptor RXR 0.0019 0.0218 0.052
Brugia malayi hypothetical protein 0.0019 0.0218 0.052
Loa Loa (eye worm) hypothetical protein 0.0008 0.0055 0.0131
Brugia malayi RasGEF domain containing protein 0.0006 0.0033 0.0078
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0008 0.0055 0.0131
Echinococcus multilocularis smad 0.0008 0.0058 0.0058
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0747 0.1781
Schistosoma mansoni serine/threonine protein kinase 0.0004 0.0003 0.0003
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1272 0.1272
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0402 0.2982
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0555 0.7956 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0525 0.1253
Echinococcus granulosus thyroid hormone receptor alpha 0.0163 0.2298 0.2298
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0525 0.1253
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0251 0.0598
Schistosoma mansoni hypothetical protein 0.0033 0.0421 0.0421
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1623 0.3869
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0405 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1272 0.347
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0218 0.0218
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0525 0.0525
Onchocerca volvulus 0.0049 0.0657 0.1565
Brugia malayi Pre-SET motif family protein 0.0032 0.0405 0.0966
Echinococcus granulosus son of sevenless 1 0.0006 0.0033 0.0033
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0055 0.0055
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0218 0.052
Leishmania major hypothetical protein, conserved 0.0022 0.0256 0.2009
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0601 0.1592
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0033 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1452 0.3461
Echinococcus granulosus cGMP dependent protein kinase 1 0.0004 0.0003 0.0003
Trypanosoma brucei beta lactamase 0.0062 0.084 0.6351
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Schistosoma mansoni smad1 5 8 and 0.0008 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0033 0.0421 0.0421
Onchocerca volvulus 0.0009 0.0069 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0525 0.1253
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1272 0.347
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0525 0.1253
Schistosoma mansoni rab6-interacting 0.0041 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0004 0.0001 0.0001
Echinococcus multilocularis expressed protein 0.0047 0.0615 0.0615
Brugia malayi mbt repeat family protein 0.0049 0.065 0.1548
Schistosoma mansoni thyroid hormone receptor 0.004 0.0525 0.0525
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0086 0.0672
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0525 0.1253
Schistosoma mansoni rotamase 0.0033 0.0413 0.0413
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0046 0.0609 0.4649
Brugia malayi N-terminal motif family protein 0.0006 0.0033 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0525 0.1253
Onchocerca volvulus 0.0049 0.065 0.1546
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0615 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0421 0.1003
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0033 0.0033
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0086 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0747 0.1781
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0525 0.1253
Brugia malayi MH2 domain containing protein 0.0008 0.0058 0.0138
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0028 0.0028
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0525 0.0525
Schistosoma mansoni amine oxidase 0.0004 0.0001 0.0001
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0055 0.0055
Brugia malayi Pre-SET motif family protein 0.0223 0.3161 0.7535
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0033 0.0033
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0107 0.0836
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0069 0.0161
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0525 0.1253
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0218 0.0518
Schistosoma mansoni dishevelled 0.0009 0.0069 0.0069
Echinococcus granulosus Smad4 0.0008 0.0058 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0525 0.1253
Loa Loa (eye worm) hypothetical protein 0.0008 0.0055 0.0131
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0058 0.0058
Loa Loa (eye worm) lethal protein 721 0.0004 0.0001 0.0002
Echinococcus granulosus cGMP dependent protein kinase 0.0004 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0525 0.1253
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.045 0.045
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0218 0.0518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0525 0.1253
Schistosoma mansoni thyroid hormone receptor 0.004 0.0525 0.0525
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0747 0.0747
Brugia malayi nuclear hormone receptor 0.0019 0.0218 0.052
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0055 0.0131
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2725 0.2725
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0525 0.0525
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0525 0.1253
Loa Loa (eye worm) hypothetical protein 0.0071 0.0975 0.2324
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0041 0.0536 0.1278
Brugia malayi hypothetical protein 0.0036 0.0458 0.1093
Schistosoma mansoni nuclear receptor 0.0019 0.0218 0.0218
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0256 0.1433
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0033 0.0078
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0525 0.1253
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0218 0.052
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0536 0.8711
Brugia malayi hypothetical protein 0.0036 0.0458 0.1093
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.004 0.0514 0.0514
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0058 0.0058
Schistosoma mansoni smad1 5 8 and 0.0008 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0035 0.045 0.3364
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0218 0.0218
Brugia malayi hypothetical protein 0.0009 0.0069 0.0163
Echinococcus granulosus smad 0.0008 0.0058 0.0058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0421 0.0421
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0069 0.0069
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0615 0.697
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0651 0.1551
Brugia malayi MH2 domain containing protein 0.0116 0.1623 0.3869
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.065 0.065
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0525 0.125
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0882 0.0882
Trichomonas vaginalis hypothetical protein 0.0033 0.042 0.1084
Brugia malayi Smad1 0.0008 0.0058 0.0138
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0069 0.0069
Brugia malayi mbt repeat family protein 0.0049 0.065 0.1548
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1272 0.347
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0129 0.181 0.2274
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.045 0.045
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0218 0.052
Brugia malayi MH2 domain containing protein 0.0008 0.0058 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1272 0.347
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0069 0.0069
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Loa Loa (eye worm) hypothetical protein 0.0021 0.0251 0.0598
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0055 0.0055
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0882 0.0882
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0405 0.0405
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0525 0.0525
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0405 0.0405
Schistosoma mansoni dishevelled 0.0009 0.0069 0.0069
Loa Loa (eye worm) MBCTL1 0.0056 0.0747 0.1781
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0086 0.097
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0086 0.0672
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0525 0.0525
Echinococcus granulosus prenylcysteine oxidase 0.0004 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0405 0.0405
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0055 0.0055
Onchocerca volvulus 0.0041 0.0536 0.1276
Echinococcus granulosus geminin 0.0165 0.2327 0.2327
Echinococcus granulosus FTZ F1 alpha 0.004 0.0525 0.0525
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0747 0.0747
Schistosoma mansoni dep domain containing protein 0.0009 0.0069 0.0069
Echinococcus granulosus expressed protein 0.0047 0.0615 0.0615
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0069 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0514 0.1225
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0218 0.052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0525 0.1253
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0413 0.0986
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0651 0.0651
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0069 0.0163
Schistosoma mansoni hypothetical protein 0.0165 0.2327 0.2327
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0008 0.0055 0.0055
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0536 0.0536
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0525 0.0525
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0525 0.1253
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0069 0.0069
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0525 0.0525
Echinococcus multilocularis prenylcysteine oxidase 0.0004 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.065 0.1546
Loa Loa (eye worm) hypothetical protein 0.004 0.0525 0.1253
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0008 0.0055 0.0131
Schistosoma mansoni polycystin 1-related 0.0041 0.0536 0.0536
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.045 0.045
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.3161 0.7535
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0218 0.0218
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1452 0.3461
Leishmania major protein kinase, putative 0.0004 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0251 0.0598
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0525 0.0525
Echinococcus granulosus RUN 0.0041 0.0536 0.0536
Schistosoma mansoni nuclear receptor 0.0019 0.0218 0.0218
Echinococcus multilocularis GPCR, family 2 0.0033 0.0421 0.0421
Entamoeba histolytica hypothetical protein 0.0011 0.0107 0.0601
Loa Loa (eye worm) hypothetical protein 0.0021 0.0251 0.0598
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0251 0.0251
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0011 0.0107 0.0836
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0218 0.0218
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0514 0.5819
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0055 0.0055
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0033 0.0033
Trypanosoma cruzi hypothetical protein 0.0004 0.0007 0.0043
Loa Loa (eye worm) hypothetical protein 0.0009 0.0069 0.0163
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0055 0.0055
Schistosoma mansoni zinc finger protein 0.0019 0.0218 0.0218
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0615 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0218 0.052
Onchocerca volvulus 0.0254 0.3605 0.8594
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0008 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0032 0.0405 0.0966
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0536 0.8711
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0055 0.0055
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0069 0.0163
Loa Loa (eye worm) hypothetical protein 0.0021 0.0251 0.0598
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0055 0.0062
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.1272 0.1272
Onchocerca volvulus 0.0041 0.0536 0.1276
Echinococcus multilocularis expressed conserved protein 0.0004 0.0003 0.0003
Brugia malayi hypothetical protein 0.0041 0.0536 0.1278
Echinococcus multilocularis expressed protein 0.0033 0.0413 0.0413
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.1272 0.1272
Schistosoma mansoni hypothetical protein 0.0041 0.0536 0.0536
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0055 0.0055
Loa Loa (eye worm) DR-78 0.0019 0.0218 0.052
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1272 0.3033
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0525 0.1253
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0421 0.0421
Schistosoma mansoni hypothetical protein 0.0033 0.0421 0.0421
Entamoeba histolytica hypothetical protein 0.0035 0.045 0.3364
Onchocerca volvulus 0.0006 0.0033 0.0076
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0536 0.0536
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0882 0.1108
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1272 0.1272
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0008 0.0055 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0601 0.1592
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0055 0.0131
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0421 0.1003
Entamoeba histolytica hypothetical protein 0.0035 0.045 0.3364
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.2483 0.5918

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 19 nM Concentration required to inhibit [3H]-BTX binding to Sodium channel of rat brain ChEMBL. 15177465
IC50 (binding) = 19 nM Concentration required to inhibit [3H]-BTX binding to Sodium channel of rat brain ChEMBL. 15177465
IC50 (functional) = 1000 nM Cytoprotection of SH-SY5Y cells against veratridine-induced cytotoxicity ChEMBL. 15177465
IC50 (functional) = 1000 nM Cytoprotection of SH-SY5Y cells against veratridine-induced cytotoxicity ChEMBL. 15177465

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15177465

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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