Detailed information for compound 215772

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.459 | Formula: C20H27N5O5
  • H donors: 3 H acceptors: 2 LogP: 0.41 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)CCN(C(=O)c1cc(OCCCON=C(N)N)cc(c1)C)Cc1ccoc1
  • InChi: 1S/C20H27N5O5/c1-14-9-16(11-17(10-14)29-6-2-7-30-24-20(22)23)19(27)25(5-3-18(21)26)12-15-4-8-28-13-15/h4,8-11,13H,2-3,5-7,12H2,1H3,(H2,21,26)(H4,22,23,24)
  • InChiKey: VGDROPDTBCAHKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0014 0.0024 0.0024
Loa Loa (eye worm) inositol-1 0.0131 0.1773 0.2481
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.1042
Plasmodium falciparum phd finger protein, putative 0.0051 0.058 0.176
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0207 0.2916 0.2916
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0014 0.0024 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0059 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0117 0.1568 0.2663
Echinococcus granulosus peregrin 0.0053 0.0613 0.1041
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0309 0.0799
Brugia malayi hypothetical protein 0.0235 0.3337 0.467
Brugia malayi beta-lactamase 0.006 0.0708 0.0991
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0131 0.0337
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0434 0.1235
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0024
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0059 0.0083
Loa Loa (eye worm) TAR-binding protein 0.0045 0.0484 0.0678
Brugia malayi Inositol-1 0.0131 0.1773 0.2481
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0434 0.1235
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0117 0.1567 0.2807
Echinococcus multilocularis neutral alpha glucosidase AB 0.0028 0.023 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.023 0.063
Schistosoma mansoni hypothetical protein 0.0048 0.053 0.0901
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.007
Echinococcus granulosus pyruvate kinase 0.0033 0.0309 0.0524
Onchocerca volvulus Serine\/threonine kinase homolog 0.0084 0.1071 0.8214
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0041 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0207 0.2916 0.4953
Trypanosoma cruzi chloride channel protein, putative 0.0014 0.0024 0.0021
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0059 0.0059
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0131 0.1773 0.5529
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0131 0.0229
Loa Loa (eye worm) GMP reductase 0.0099 0.13 0.1819
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Schistosoma mansoni polycystin 1-related 0.0024 0.0172 0.0292
Brugia malayi Bromodomain containing protein 0.0053 0.0613 0.0857
Giardia lamblia Pyruvate kinase 0.0033 0.0309 0.0919
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0059 0.0125
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0059 0.0059
Brugia malayi beta-lactamase family protein 0.006 0.0708 0.0991
Leishmania major chloride channel protein, putative 0.0014 0.0024 0.0021
Brugia malayi Kringle domain containing protein 0.0021 0.0131 0.0183
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.023 0.067
Mycobacterium tuberculosis Conserved protein 0.006 0.0708 0.1251
Toxoplasma gondii PHD-finger domain-containing protein 0.0017 0.0063 0.0135
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0277 0.0769
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0067 0.0135
Echinococcus granulosus dna polymerase eta 0.0023 0.0164 0.0279
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0164 0.023
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0309 0.0919
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0785 0.1099
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.1071 0.1819
Mycobacterium tuberculosis Conserved protein 0.006 0.0708 0.1251
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0172 0.024
Echinococcus multilocularis zinc finger protein 0.0019 0.0101 0.0101
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.1042
Trichomonas vaginalis penicillin-binding protein, putative 0.006 0.0708 0.2176
Chlamydia trachomatis CBS domain-containing protein 0.0014 0.0024 0.0245
Loa Loa (eye worm) hypothetical protein 0.0021 0.0131 0.0183
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0014 0.0024 0.0041
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0131 0.1773 0.519
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0014 0.0024 0.0024
Echinococcus multilocularis lysosomal alpha glucosidase 0.0126 0.1696 0.1696
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0172 0.0292
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0014 0.0024 0.0041
Schistosoma mansoni chloride channel protein 0.0014 0.0024 0.0041
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0059 0.0101
Echinococcus granulosus pyruvate kinase 0.0017 0.0067 0.0113
Schistosoma mansoni aldehyde dehydrogenase 0.0207 0.2916 0.4953
Echinococcus granulosus cpg binding protein 0.0023 0.016 0.0273
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.1773 0.52
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0172 0.036
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0309 0.0864
Echinococcus granulosus PHD finger protein rhinoceros 0.0051 0.058 0.0985
Schistosoma mansoni hypothetical protein 0.0021 0.0131 0.0222
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0164 0.0436
Mycobacterium ulcerans lipase LipD 0.006 0.0708 0.2047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0785 0.1334
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0014 0.0024 0.0013
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0299 0.0299
Mycobacterium ulcerans hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi TAR-binding protein 0.0045 0.0484 0.0678
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0131 0.1773 0.5529
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0435 0.1316
Schistosoma mansoni pyruvate kinase 0.0033 0.0309 0.0524
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0059 0.0126
Onchocerca volvulus 0.0073 0.0902 0.6894
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0172 0.0172
Mycobacterium ulcerans hypothetical protein 0.0014 0.0024 0.0021
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0158 0.0445
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0131 0.1773 0.52
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0014 0.0024 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0207 0.2916 0.8585
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0059 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0028 0.0039
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0239 0.3394 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0117 0.1568 0.1568
Giardia lamblia PHD finger protein 15 0.0051 0.058 0.1772
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.1773 0.52
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0312 0.0529
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0225 0.3181 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0164 0.0164
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0059 0.0126
Schistosoma mansoni cpg binding protein 0.0023 0.016 0.0273
Schistosoma mansoni hypothetical protein 0.029 0.4157 0.7061
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0164 0.0436
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0225 0.3181 0.937
Loa Loa (eye worm) MH2 domain-containing protein 0.0184 0.258 0.361
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0117 0.1568 0.2663
Loa Loa (eye worm) hypothetical protein 0.006 0.0708 0.0991
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0434 0.0607
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0126 0.1696 0.2374
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.011 0.1463 0.2619
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0067 0.0024
Toxoplasma gondii PHD-finger domain-containing protein 0.0051 0.058 0.1667
Loa Loa (eye worm) hypothetical protein 0.006 0.0708 0.0991
Leishmania major hypothetical protein, conserved 0.0017 0.0059 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1071 0.3319
Brugia malayi jmjC domain containing protein 0.0168 0.2328 0.3258
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0169 0.0236
Toxoplasma gondii IMP dehydrogenas 0.0239 0.3394 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0059 0.0125
Toxoplasma gondii PHD-finger domain-containing protein 0.0051 0.058 0.1667
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0117 0.1568 0.2194
Echinococcus multilocularis jumonji domain containing protein 0.0071 0.0881 0.0881
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0309 0.2274
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0309 0.2274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0207 0.2916 0.8585
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0049 0.0083
Entamoeba histolytica acyl-coA synthetase, putative 0.0041 0.0434 0.1313
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0182 0.0255
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0059 0.0111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0059 0.0077
Echinococcus multilocularis dnaJ subfamily B 0.029 0.4157 0.4157
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0059 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0484 0.0823
Echinococcus multilocularis pyruvate kinase 0.0017 0.0067 0.0067
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0239 0.3394 0.3394
Leishmania major CBS domain protein, conserved 0.0014 0.0024 0.0021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0041 0.0422 0.1201
Loa Loa (eye worm) beta-lactamase 0.006 0.0708 0.0991
Brugia malayi MH2 domain containing protein 0.0184 0.258 0.361
Schistosoma mansoni pyruvate kinase 0.0017 0.0067 0.0113
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0014 0.0024 0.0023
Onchocerca volvulus 0.006 0.0708 0.5386
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0017 0.0063 0.0135
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0034
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0031 0.0277 0.047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0117 0.1568 0.2663
Schistosoma mansoni hypothetical protein 0.0051 0.058 0.0985
Loa Loa (eye worm) hypothetical protein 0.0016 0.0055 0.0078
Trypanosoma brucei unspecified product 0.0016 0.0055 0.0111
Toxoplasma gondii aldehyde dehydrogenase 0.0207 0.2916 0.8585
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0032 0.0299 0.0887
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0164 0.0436
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.011 0.1463 0.4283
Brugia malayi Protein kinase domain containing protein 0.0021 0.0131 0.0183
Schistosoma mansoni protein kinase subunit gamma 0.0014 0.0024 0.0041
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0309 0.0864
Loa Loa (eye worm) hypothetical protein 0.0066 0.0796 0.1114
Leishmania major hypothetical protein, conserved 0.006 0.0708 0.2047
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0164 0.0436
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0484 0.0823
Onchocerca volvulus Alhambra homolog 0.0051 0.058 0.4386
Leishmania major inosine-5-monophosphate dehydrogenase 0.0239 0.3394 1
Echinococcus multilocularis inositol monophosphatase 1 0.0131 0.1773 0.1773
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.1773 0.52
Schistosoma mansoni pap-inositol-14-phosphatase 0.0014 0.0017 0.0029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0016 0.0055 0.0055
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0059 0.0101
Loa Loa (eye worm) hypothetical protein 0.006 0.0708 0.0991
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.1071 0.3121
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0051 0.058 0.0985
Loa Loa (eye worm) hypothetical protein 0.006 0.0708 0.0991
Brugia malayi Doublecortin family protein 0.0024 0.0172 0.024
Plasmodium vivax hypothetical protein, conserved 0.0051 0.058 0.1667
Leishmania major hypothetical protein, conserved 0.0021 0.0131 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1071 0.3319
Leishmania major guanosine monophosphate reductase 0.0239 0.3394 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0172 0.0172
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.3337 0.3337
Schistosoma mansoni kinase 0.0043 0.0452 0.0767
Toxoplasma gondii CBS domain-containing protein 0.0014 0.0024 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0164 0.0436
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0164 0.0436
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0125 0.1692 0.4961
Trichomonas vaginalis inositol monophosphatase, putative 0.0131 0.1773 0.5529
Loa Loa (eye worm) hypothetical protein 0.0235 0.3337 0.467
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0207 0.2916 0.4953
Leishmania major pyruvate kinase 0.0033 0.0309 0.0864
Trypanosoma brucei unspecified product 0.0023 0.0164 0.0436
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0034
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0164 0.0463
Leishmania major hypothetical protein, conserved 0.0014 0.0024 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0207 0.2916 0.5249
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0708 0.2047
Brugia malayi serine/threonine-protein kinase plk-2 0.0084 0.1071 0.1499
Brugia malayi Cytochrome P450 family protein 0.0014 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0537 0.0752
Schistosoma mansoni ap endonuclease 0.0017 0.0059 0.0101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0172 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0251 0.0424
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0434 0.0607
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0131 0.0337
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0103 0.0103
Leishmania major chloride channel protein, putative 0.0014 0.0024 0.0021
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.023 0.067
Brugia malayi Bromodomain containing protein 0.0071 0.0873 0.1221
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0434 0.1235
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0164 0.0279
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0059 0.0101
Schistosoma mansoni hypothetical protein 0.0405 0.5887 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0055 0.0094
Schistosoma mansoni pyruvate kinase 0.0033 0.0309 0.0524
Echinococcus multilocularis inositol monophosphatase 0.0014 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1071 0.3319
Mycobacterium tuberculosis Probable lipase LipE 0.006 0.0708 0.1251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0348 0.0348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Brugia malayi chloride channel protein 7 0.0014 0.0024 0.0034
Schistosoma mansoni cpg binding protein 0.0023 0.016 0.0273
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0032 0.0299 0.0507
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0239 0.3394 1
Loa Loa (eye worm) IMP dehydrogenase 1 0.0239 0.3394 0.4749
Giardia lamblia Kinase, PLK 0.0084 0.1071 0.3319
Loa Loa (eye worm) PHD-finger family protein 0.0051 0.058 0.0811
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Brugia malayi Voltage gated chloride channel family protein 0.0014 0.0024 0.0034
Echinococcus multilocularis PHD finger protein rhinoceros 0.0051 0.058 0.058
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0239 0.3394 0.5765
Mycobacterium ulcerans cystathionine beta-synthase 0.0014 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0041 0.0422 0.0591
Echinococcus multilocularis lysosomal alpha glucosidase 0.0126 0.1696 0.1696
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Trichomonas vaginalis esterase, putative 0.006 0.0708 0.2176
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.006 0.0708 0.1203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.0116 0.0163
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0309 0.0432
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0049 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0345 0.0483
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0138 0.0235
Loa Loa (eye worm) transcription factor SMAD2 0.0184 0.258 0.361
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.006 0.0708 0.1251
Brugia malayi Glycosyl hydrolases family 31 protein 0.0126 0.1696 0.2374
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0014 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0309 0.0432
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0017 0.0063 0.0135
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0014 0.0024 0.0041
Echinococcus multilocularis ubiquitin specific protease 41 0.0032 0.0299 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0055 0.0111
Echinococcus granulosus RUN 0.0024 0.0172 0.0292
Echinococcus granulosus dna polymerase kappa 0.0023 0.0164 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0059 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Mycobacterium tuberculosis Conserved protein 0.006 0.0708 0.1251
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0239 0.3394 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0251 0.0424
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0084 0.1071 0.1819
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0131 0.1773 0.52
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0309 0.0864
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1071 0.3319
Loa Loa (eye worm) loechrig isoform VII 0.0014 0.0024 0.0034
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.006 0.0708 0.2047
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0103 0.0176
Plasmodium vivax hypothetical protein, conserved 0.006 0.0708 0.2078
Schistosoma mansoni chloride channel protein 0.0014 0.0024 0.0041
Leishmania major cytochrome p450-like protein 0.0014 0.0028 0.0032
Schistosoma mansoni lipoxygenase 0.0024 0.0172 0.0292
Echinococcus granulosus lysosomal alpha glucosidase 0.0126 0.1696 0.2882
Brugia malayi PHD-finger family protein 0.0051 0.058 0.0811
Echinococcus multilocularis cpg binding protein 0.0023 0.016 0.016
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0059 0.0083
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0239 0.3394 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0023 0.0158 0.0221
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0207 0.2916 0.8585
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0308 0.043
Brugia malayi hypothetical protein 0.0024 0.0172 0.024
Brugia malayi Cytochrome P450 family protein 0.0024 0.0169 0.0236
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.023 0.067
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0164 0.0279
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.023 0.067
Loa Loa (eye worm) hypothetical protein 0.0041 0.0434 0.0607
Mycobacterium tuberculosis Probable hydrolase 0.006 0.0708 0.1251
Schistosoma mansoni zinc finger protein 0.0014 0.0024 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.023 0.063
Echinococcus granulosus geminin 0.0405 0.5887 1
Loa Loa (eye worm) chloride channel protein 7 0.0014 0.0024 0.0034
Brugia malayi ancient conserved domain protein 2 0.0014 0.0024 0.0034
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0299 0.0834
Echinococcus multilocularis pyruvate kinase 0.0017 0.0067 0.0067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0164 0.0266
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0113 0.1513 0.443
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0059 0.0112
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0299 0.0834
Brugia malayi jmjC domain containing protein 0.0017 0.0059 0.0083
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0041 0.0434 0.1235
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0172 0.0467
Onchocerca volvulus 0.006 0.0708 0.5386
Schistosoma mansoni ap endonuclease 0.0017 0.0059 0.0101
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0014 0.0024 0.0021
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0059 0.0101
Schistosoma mansoni alpha-glucosidase 0.0108 0.1434 0.2436
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0309 0.0432
Onchocerca volvulus 0.0024 0.0172 0.1206
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.066 0.1121
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0131 0.1773 0.52
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0014 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Echinococcus granulosus jumonji domain containing protein 0.0071 0.0881 0.1496
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0225 0.3181 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0014 0.0024 0.0041
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0032 0.0299 0.0507
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0059 0.0101
Echinococcus multilocularis pyruvate kinase 0.0033 0.0309 0.0309
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.066 0.066
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0131 0.0131
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.1042
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0113 0.1513 0.443
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0168 0.2328 0.3954
Brugia malayi CLC chloride channel protein 0.0014 0.0024 0.0034
Schistosoma mansoni hypothetical protein 0.0014 0.0024 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0117 0.1568 0.1568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Schistosoma mansoni inositol monophosphatase 0.0131 0.1773 0.3012
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0434 0.1235
Giardia lamblia Fructose-bisphosphate aldolase 0.0225 0.3193 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.006 0.0708 0.1251
Brugia malayi Bromodomain containing protein 0.0036 0.0344 0.0482
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.023 0.067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.0434 0.1313
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.053 0.0742
Giardia lamblia Pyruvate kinase 0.0017 0.0067 0.0156
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0059 0.0133
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0131 0.1773 0.5529
Brugia malayi jmjC domain containing protein 0.0017 0.0059 0.0083
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0309 0.0432
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0251 0.0424
Loa Loa (eye worm) hypothetical protein 0.002 0.0107 0.0149
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0049 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1071 0.3319
Brugia malayi hypothetical protein 0.0024 0.0172 0.024
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.3337 0.5668
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0239 0.3394 1
Schistosoma mansoni zinc finger protein 0.0019 0.0101 0.0172
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0014 0.0024 0.0013
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0059 0.0104
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0164 0.0266
Schistosoma mansoni alpha-glucosidase 0.0108 0.1434 0.2436
Trypanosoma brucei glucosidase, putative 0.0028 0.023 0.063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0434 0.0755
Trypanosoma brucei polo-like protein kinase 0.0084 0.1071 0.3121
Entamoeba histolytica serine/threonine protein kinase, putative 0.0084 0.1071 0.3319
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0537 0.0752
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0014 0.0024 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0164 0.0436
Trypanosoma cruzi chloride channel protein, putative 0.0014 0.0024 0.0021
Echinococcus multilocularis tar DNA binding protein 0.0045 0.0484 0.0484
Onchocerca volvulus 0.0048 0.053 0.4002
Echinococcus granulosus GPCR family 2 0.0015 0.0041 0.007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0378 0.053
Mycobacterium tuberculosis Probable lipase LipD 0.006 0.0708 0.1251
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0117 0.1567 0.4592
Loa Loa (eye worm) hypothetical protein 0.0031 0.0277 0.0387
Loa Loa (eye worm) hypothetical protein 0.0041 0.0434 0.0607
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.082 0.082
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0172 0.0172
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0059 0.0126
Trypanosoma cruzi chloride channel protein, putative 0.0014 0.0024 0.0021
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0741 0.0741
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0041 0.0434 0.1235
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0059 0.0133
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0435 0.1316
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0014 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Chlamydia trachomatis Mg++ transporter 0.0014 0.0024 0.0245
Trypanosoma brucei hypothetical protein, conserved 0.006 0.0708 0.2047
Brugia malayi follicle stimulating hormone receptor 0.0489 0.7146 1
Mycobacterium tuberculosis Conserved protein 0.0014 0.0024 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0537 0.0752
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0522
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0014 0.0024 0.0021
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0489 0.7146 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0299 0.0887
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0059 0.0059
Schistosoma mansoni survival motor neuron protein 0.0048 0.053 0.0901
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0239 0.3394 0.5765
Plasmodium vivax acyl-CoA synthetase, putative 0.0031 0.0277 0.0696
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0018 0.0081 0.0181
Mycobacterium tuberculosis Conserved protein 0.0014 0.0024 0.0013
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0059 0.0126
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.1071 0.3121
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0014 0.0024 0.0021
Echinococcus multilocularis GPCR, family 2 0.0015 0.0041 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0785 0.1334
Brugia malayi loechrig isoform VII 0.0014 0.0024 0.0034
Loa Loa (eye worm) chloride channel 3 0.0014 0.0024 0.0034
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0239 0.3394 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0099 0.13 0.1819
Schistosoma mansoni rab6-interacting 0.0024 0.0172 0.0292
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.006 0.0708 0.0991
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0484 0.0823
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.1042
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.1398 0.1956
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0059 0.0125
Echinococcus multilocularis pyruvate kinase 0.0033 0.0309 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Loa Loa (eye worm) hypothetical protein 0.0051 0.058 0.0811
Schistosoma mansoni alpha glucosidase 0.0028 0.023 0.039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0434 0.0607
Trichomonas vaginalis D-aminoacylase, putative 0.006 0.0708 0.2176
Mycobacterium tuberculosis Probable esterase LipL 0.006 0.0708 0.1251
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0309 0.0919
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0131 0.0338
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0017 0.0063 0.0135
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0239 0.3394 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0225 0.3193 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0348 0.0591
Brugia malayi jmjC domain containing protein 0.0017 0.0059 0.0083
Trypanosoma brucei unspecified product 0.0016 0.0055 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0484 0.0823
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0031 0.0277 0.8899
Schistosoma mansoni cpg binding protein 0.002 0.0116 0.0198
Loa Loa (eye worm) hypothetical protein 0.0088 0.1129 0.1579
Echinococcus granulosus zinc finger protein 0.0019 0.0101 0.0172
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0434 0.0607
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0309 0.0864
Mycobacterium ulcerans esterase/lipase LipP 0.006 0.0708 0.2047
Plasmodium vivax JmjC domain containing protein 0.0017 0.0059 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0059 0.0125
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0164 0.0463
Echinococcus granulosus phd:f box containing protein 0.0017 0.0059 0.0101
Echinococcus granulosus dnaJ subfamily B 0.029 0.4157 0.7061
Echinococcus granulosus inositol monophosphatase 0.0014 0.0017 0.0029
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0028 0.0039
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0299 0.0507
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.043
Mycobacterium leprae Probable lipase LipE 0.006 0.0708 0.2047
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0014 0.0024 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0459 0.0779
Loa Loa (eye worm) hypothetical protein 0.0031 0.0277 0.0387
Echinococcus granulosus H:Cl exchange transporter 7 0.0014 0.0024 0.0041
Onchocerca volvulus 0.006 0.0708 0.5386
Echinococcus granulosus beta LACTamase domain containing family member 0.006 0.0708 0.1203
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0032 0.0299 0.0834
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0045 0.0484 0.0678
Echinococcus multilocularis beta LACTamase domain containing family member 0.006 0.0708 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0299 0.0887
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0028 0.0032
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0309 0.0864
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0084 0.1071 0.3121
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0014 0.0024 0.0013
Brugia malayi CBS domain containing protein 0.0014 0.0024 0.0034
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0172 0.0292
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0168 0.2328 0.2328
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0785 0.1334
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0084 0.1071 0.1071
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0484 0.0823
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0382 0.554 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0055 0.0111
Echinococcus multilocularis dna polymerase eta 0.0023 0.0164 0.0164
Trypanosoma brucei GMP reductase 0.0239 0.3394 1
Brugia malayi beta-lactamase family protein 0.006 0.0708 0.0991
Brugia malayi Inositol monophosphatase family protein 0.0014 0.0017 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0032 0.0299 0.0887
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0055 0.0111
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0014 0.0024 0.0245
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0014 0.0024 0.0021
Toxoplasma gondii CBS domain-containing protein 0.0014 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0299 0.0418
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0028 0.0032
Schistosoma mansoni inositol monophosphatase 0.0131 0.1773 0.3012
Brugia malayi PHD-finger family protein 0.0024 0.0176 0.0246
Leishmania major alpha glucosidase II subunit, putative 0.0028 0.023 0.063
Plasmodium falciparum pyruvate kinase 0.0033 0.0309 0.0902
Echinococcus multilocularis geminin 0.0405 0.5887 0.5887
Schistosoma mansoni jumonji domain containing protein 0.0133 0.1811 0.3076
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0059 0.0111
Echinococcus granulosus tar DNA binding protein 0.0045 0.0484 0.0823
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0434 0.1235
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.023 0.067
Echinococcus granulosus H:Cl exchange transporter 4 0.0014 0.0024 0.0041
Mycobacterium ulcerans hypothetical protein 0.0041 0.0434 0.1235
Schistosoma mansoni loxhd1 0.0024 0.0172 0.0292
Mycobacterium ulcerans aldehyde dehydrogenase 0.0207 0.2916 0.8585
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0143 0.0242
Schistosoma mansoni rab6-interacting 0.0024 0.0172 0.0292
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0014 0.0024 0.0024
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0143 0.0242
Brugia malayi Cytochrome P450 family protein 0.0014 0.0028 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0117 0.1568 0.2194
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0028 0.023 0.0321
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0049 0.0083
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0312 0.0312
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0164 0.023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Onchocerca volvulus 0.002 0.0116 0.0776
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0059 0.0125
Loa Loa (eye worm) hypothetical protein 0.0031 0.0277 0.0387
Mycobacterium tuberculosis Conserved protein 0.0014 0.0024 0.0013
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0309 0.0528
Trypanosoma cruzi chloride channel protein, putative 0.0014 0.0024 0.0021
Echinococcus granulosus neutral alpha glucosidase AB 0.0028 0.023 0.039
Schistosoma mansoni chloride channel protein 0.0014 0.0024 0.0041
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0099 0.0138
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0059 0.0059
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0434 0.1235
Toxoplasma gondii CBS family protein 0.0014 0.0024 0.0021
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0299 0.0299
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0041 0.0057
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0172 0.0292
Chlamydia trachomatis pyruvate kinase 0.0033 0.0309 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0028 0.023 0.067
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0041 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.0434 0.1313
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0041 0.007
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0299 0.0507
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0059 0.0083
Brugia malayi CXXC zinc finger family protein 0.002 0.0116 0.0163
Brugia malayi RNA recognition motif domain containing protein 0.0045 0.0484 0.0678
Mycobacterium ulcerans beta-lactamase 0.006 0.0708 0.2047
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.023 0.067
Mycobacterium ulcerans transcriptional regulator 0.0014 0.0024 0.0021
Schistosoma mansoni hypothetical protein 0.0017 0.0063 0.0106
Trypanosoma cruzi ISWI complex protein 0.0014 0.0024 0.0022
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0014 0.0024 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0083
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0239 0.3394 0.4749
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0309 0.2274
Loa Loa (eye worm) hypothetical protein 0.006 0.0708 0.0991
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0014 0.0024 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0055 0.0094
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0014 0.0024 0.0041
Leishmania major hypothetical protein, conserved 0.0014 0.0024 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0708 0.2047
Trichomonas vaginalis D-aminoacylase, putative 0.006 0.0708 0.2176
Schistosoma mansoni hypothetical protein 0.0405 0.5887 1
Giardia lamblia DINP protein human, muc B family 0.0023 0.0164 0.0463
Schistosoma mansoni DNA polymerase eta 0.0023 0.0164 0.0279
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0041 0.0057
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0309 0.0864
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0117 0.1568 0.2663
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0239 0.3394 0.6114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0024
Echinococcus multilocularis RUN 0.0024 0.0172 0.0172
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.011 0.1463 0.4283
Schistosoma mansoni myo inositol monophosphatase 0.0014 0.0017 0.0029
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0164 0.023
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.023 0.067
Mycobacterium ulcerans hypothetical protein 0.0014 0.0024 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.006 0.0708 0.2176
Brugia malayi jmjC domain containing protein 0.0065 0.0785 0.1099
Echinococcus granulosus pyruvate kinase 0.0033 0.0309 0.0524
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0014 0.0017 0.0029
Brugia malayi RNA binding protein 0.0045 0.0484 0.0678
Trypanosoma brucei ISWI complex protein 0.0014 0.0024 0.0022
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0059 0.0101
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0028 0.0032
Brugia malayi GMP reductase 0.0099 0.13 0.1819
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0081 0.007
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0059 0.0126
Leishmania major DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Leishmania major pyruvate kinase 0.0033 0.0309 0.0864
Echinococcus granulosus H:Cl exchange transporter 3 0.0014 0.0024 0.0041
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0014 0.0024 0.0021
Toxoplasma gondii ABC1 family protein 0.006 0.0708 0.2047
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.023 0.067
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0059 0.0059
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0225 0.3193 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0067 0.0113
Toxoplasma gondii exonuclease III APE 0.0017 0.0059 0.0125
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0032 0.0299 0.0418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0117 0.1568 0.2663
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0348 0.0591
Schistosoma mansoni hypothetical protein 0.0019 0.0099 0.0167
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.006 0.0708 0.1251
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.006 0.0708 0.0991
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0028 0.0032
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0084 0.1071 0.1499
Onchocerca volvulus 0.0021 0.0131 0.0887
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0309 0.0432
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0131 0.0222
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.082 0.1393
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0131 0.0183
Loa Loa (eye worm) RNA binding protein 0.0045 0.0484 0.0678
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1071 0.3319
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0299 0.0887
Mycobacterium leprae conserved hypothetical protein 0.006 0.0708 0.2047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.006 0.0708 0.1203
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0059 0.0133
Loa Loa (eye worm) hypothetical protein 0.006 0.0708 0.0991
Mycobacterium ulcerans hypothetical protein 0.006 0.0708 0.2047
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0059 0.0133
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0164 0.0463
Onchocerca volvulus 0.0024 0.0172 0.1206
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0067 0.0147
Onchocerca volvulus 0.0041 0.0434 0.325
Trichomonas vaginalis D-aminoacylase, putative 0.006 0.0708 0.2176
Leishmania major DNA polymerase eta, putative 0.0023 0.0164 0.0436
Schistosoma mansoni hypothetical protein 0.0024 0.0172 0.0292
Echinococcus granulosus pyruvate kinase 0.0017 0.0067 0.0113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0172 0.024
Schistosoma mansoni lipoxygenase 0.0067 0.082 0.1393
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.023 0.0321
Loa Loa (eye worm) hypothetical protein 0.0031 0.0277 0.0387
Brugia malayi jmjC domain containing protein 0.0017 0.0059 0.0083
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.007
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.023 0.067
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0158 0.0221
Echinococcus granulosus inositol monophosphatase 1 0.0131 0.1773 0.3012
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.007
Brugia malayi ancient conserved domain protein 4 0.0014 0.0024 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.1071 0.3319
Schistosoma mansoni hypothetical protein 0.0036 0.0348 0.0591
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0041 0.0434 0.1235
Trypanosoma cruzi GMP reductase 0.0239 0.3394 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0125 0.1692 0.3033
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0164 0.0436
Onchocerca volvulus Putative GMP reductase 0.0099 0.13 1
Treponema pallidum fructose-bisphosphate aldolase 0.0225 0.3193 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0041 0.0057
Onchocerca volvulus 0.0014 0.0024 0.0056
Echinococcus granulosus ubiquitin specific protease 41 0.0032 0.0299 0.0507
Trypanosoma cruzi GMP reductase 0.0239 0.3394 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0277 0.0387
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0537 0.0752
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0059 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0251 0.0424
Giardia lamblia Hypothetical protein 0.0014 0.0024 0.0023
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0299 0.0834
Schistosoma mansoni bromodomain containing protein 0.006 0.071 0.1205
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0164 0.0436
Loa Loa (eye worm) bromodomain containing protein 0.0016 0.0057 0.008
Plasmodium falciparum acyl-CoA synthetase 0.0031 0.0277 0.08
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0014 0.0024 0.0023
Echinococcus multilocularis pyruvate kinase 0.0017 0.0067 0.0067
Brugia malayi AF-10 protein 0.0017 0.0063 0.0087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0164 0.0279
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0014 0.0024 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0434 0.1235
Brugia malayi Inositol monophosphatase family protein 0.0014 0.0017 0.0024
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0309 0.0432
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0041 0.0434 0.0755
Trypanosoma cruzi ISWI complex protein 0.0014 0.0024 0.0022
Echinococcus multilocularis peregrin 0.0053 0.0613 0.0613
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0164 0.0164
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0434 0.1235
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0028 0.023 0.063
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0143 0.0143
Mycobacterium leprae conserved hypothetical protein 0.0014 0.0024 0.0021
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0099 0.13 0.1819
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0055 0.0094
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0164 0.023
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0309 0.0864
Brugia malayi hypothetical protein 0.0036 0.0348 0.0487
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0014 0.0024 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0225 0.3193 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0434 0.1235
Brugia malayi PHD-finger family protein 0.002 0.0107 0.0149

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.11 uM Inhibitory activity against thrombin ChEMBL. 15203151
Ki (binding) = 0.11 uM Inhibitory activity against thrombin ChEMBL. 15203151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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