Detailed information for compound 216290

Basic information

Technical information
  • TDR Targets ID: 216290
  • Name: 2-benzylsulfanyl-4,6-dichloropyrimidine
  • MW: 271.166 | Formula: C11H8Cl2N2S
  • H donors: 0 H acceptors: 2 LogP: 4.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(Cl)nc(n1)SCc1ccccc1
  • InChi: 1S/C11H8Cl2N2S/c12-9-6-10(13)15-11(14-9)16-7-8-4-2-1-3-5-8/h1-6H,7H2
  • InChiKey: OSSXOGKDVQWILL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-benzylsulfanyl-4,6-dichloro-pyrimidine
  • 2-(benzylthio)-4,6-dichloropyrimidine
  • 2-(benzylthio)-4,6-dichloro-pyrimidine
  • 4,6-dichloro-2-(phenylmethylsulfanyl)pyrimidine
  • 4,6-dichloro-2-(phenylmethylthio)pyrimidine
  • 4,6-Dichloro-2-[(phenylmethyl)thio]pyrimidine
  • AIDS-070163
  • AIDS070163

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0048 0.0528 0.0579
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0643 0.1347
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0643 0.1347
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Brugia malayi Serotonin receptor 0.0056 0.0643 0.0705
Loa Loa (eye worm) calpain 5 0.0012 0.002 0.0022
Echinococcus multilocularis GPCR, family 2 0.0022 0.0165 0.0219
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0019 0.0123 0.0135
Schistosoma mansoni ran 0.0015 0.006 0.0156
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0093 0.0093
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0643 0.0855
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0012 0.0028 0.0028
Echinococcus granulosus g protein coupled receptor 0.0056 0.0643 0.1347
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0643 0.167
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0652 0.9116 0.9116
Schistosoma mansoni importin beta-1 0.002 0.0135 0.035
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0643 0.1347
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Onchocerca volvulus Glucosylceramidase homolog 0.0113 0.1454 0.3705
Loa Loa (eye worm) hypothetical protein 0.0348 0.4805 0.5271
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0643 0.1347
Echinococcus multilocularis calpain family protein 1, d 0.0033 0.0323 0.0429
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.026
Echinococcus multilocularis cathepsin b 0.0057 0.0658 0.0874
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0643 0.167
Brugia malayi calpain 7 0.0017 0.0093 0.0102
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0072 0.0879 0.2495
Loa Loa (eye worm) hypothetical protein 0.0045 0.0491 0.0539
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0165 0.0181
Onchocerca volvulus 0.0056 0.0643 0.1446
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni copper/topaquinone oxidase 0.0173 0.2312 0.6005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0081 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0297
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0643 0.1347
Schistosoma mansoni hypothetical protein 0.0056 0.0643 0.167
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0057 0.0658 0.0658
Brugia malayi Melatonin receptor type 1A 0.0056 0.0643 0.0705
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0016 0.008 0.0107
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0643 0.167
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0015 0.006 0.2533
Echinococcus multilocularis transfer RNA-Lys 0.0077 0.0944 0.1256
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.0235
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0172 0.2294 0.2516
Trichomonas vaginalis glucosylceramidase, putative 0.0113 0.1454 0.6241
Echinococcus granulosus g protein coupled receptor 0.0056 0.0643 0.1347
Trypanosoma cruzi kinesin, putative 0.0012 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.006 0.0066
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0093 0.0093
Mycobacterium ulcerans putative regulatory protein 0.0077 0.0944 0.3067
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2294 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0165 0.0181
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0643 0.0705
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.2166
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.154 0.6627
Onchocerca volvulus 0.0056 0.0643 0.1446
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0034 0.007
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0235 0.0493
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0643 0.0705
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0172 0.2294 0.2516
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0028 0.0028
Echinococcus granulosus serotonin receptor 0.0056 0.0643 0.1347
Echinococcus granulosus calpain A 0.0017 0.0093 0.0195
Toxoplasma gondii hypothetical protein 0.0027 0.0237 0.2166
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0643 0.1347
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni myosin xvIII 0.0056 0.0643 0.167
Brugia malayi AKH receptor 0.0056 0.0643 0.0705
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0012 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0281 0.385 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0408 0.0542
Schistosoma mansoni opsin-like receptor 0.0056 0.0643 0.167
Schistosoma mansoni jun-related protein 0.0281 0.385 1
Brugia malayi Cytochrome P450 family protein 0.0012 0.0028 0.0031
Echinococcus granulosus calpain A 0.0047 0.052 0.109
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Onchocerca volvulus 0.016 0.2122 0.5564
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0643 0.0855
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0021
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0643 0.1347
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) calpain family protein 1 0.0033 0.0323 0.0354
Brugia malayi bZIP transcription factor family protein 0.0346 0.4771 0.5234
Loa Loa (eye worm) hypothetical protein 0.0652 0.9116 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0235 0.0785
Loa Loa (eye worm) norepinephrine transporter 0.016 0.2122 0.2327
Mycobacterium ulcerans phytoene synthase, CrtB 0.0223 0.3015 1
Echinococcus granulosus importin subunit beta 1 0.002 0.0135 0.0283
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0643 0.167
Loa Loa (eye worm) calpain family protein 1 0.0045 0.0491 0.0539
Loa Loa (eye worm) hypothetical protein 0.016 0.2122 0.2327
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0643 0.1446
Echinococcus multilocularis calpain 0.0017 0.0093 0.0124
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.0237 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0237 0.0616
Brugia malayi neuropeptide F receptor 0.0056 0.0643 0.0705
Brugia malayi RNA binding protein 0.0046 0.051 0.0559
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0011 0.0013 0.0017
Echinococcus multilocularis zinc finger protein 0.0014 0.0052 0.007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0012 0.0019 0.0025
Leishmania major C-8 sterol isomerase-like protein 0.0652 0.9116 0.9116
Echinococcus granulosus calpain 7 C02 family 0.0017 0.0093 0.0195
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0432 0.0905
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0235 0.0235
Schistosoma mansoni jumonji domain containing protein 0.0039 0.0408 0.1059
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0047 0.052 0.1351
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0643 0.167
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2294 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0237 0.0616
Schistosoma mansoni calpain-7 (C02 family) 0.0017 0.0093 0.0241
Schistosoma mansoni hypothetical protein 0.0022 0.0165 0.0428
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0643 0.0705
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0643 0.0705
Brugia malayi Calcitonin receptor-like protein seb-1 0.007 0.0841 0.0922
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0643 0.0855
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0643 0.0705
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0024 0.0191 0.0401
Brugia malayi jmjC domain containing protein 0.0039 0.0408 0.0447
Schistosoma mansoni hypothetical protein 0.0022 0.0165 0.0428
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0235 0.0258
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0235 0.0785
Plasmodium falciparum transporter, putative 0.0027 0.0237 1
Schistosoma mansoni neuropeptide receptor 0.0056 0.0643 0.167
Loa Loa (eye worm) pigment dispersing factor receptor c 0.007 0.0841 0.0922
Schistosoma mansoni tar DNA-binding protein 0.0046 0.051 0.1324
Leishmania major protein kinase, putative 0.0027 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0235 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0012 0.0019 0.0049
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0643 0.0855
Toxoplasma gondii hypothetical protein 0.0027 0.0237 0.2166
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0643 0.0855
Echinococcus granulosus tar DNA binding protein 0.0046 0.051 0.1068
Loa Loa (eye worm) cytochrome P450 0.0012 0.0028 0.0031
Brugia malayi PHD-finger family protein 0.0018 0.0103 0.0113
Loa Loa (eye worm) cathepsin B 0.0019 0.0118 0.0129
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0643 0.167
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0643 0.1347
Brugia malayi neuropeptide F receptor 0.0056 0.0643 0.0705
Onchocerca volvulus 0.0056 0.0643 0.1446
Leishmania major hypothetical protein, conserved 0.0223 0.3015 0.3015
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0643 0.0705
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0652 0.9116 1
Leishmania major cytochrome p450-like protein 0.0012 0.0028 0.0028
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0643 0.167
Toxoplasma gondii hypothetical protein 0.0087 0.1094 1
Onchocerca volvulus 0.0056 0.0643 0.1446
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Echinococcus granulosus cathepsin b 0.0057 0.0658 0.1378
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0235 0.0785
Brugia malayi latrophilin 2 splice variant baaae 0.0048 0.0528 0.0579
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0643 0.0855
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0643 0.0855
Brugia malayi PAS domain containing protein 0.0104 0.1328 0.1457
Trypanosoma brucei C-8 sterol isomerase, putative 0.0652 0.9116 0.9116
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0237 1
Schistosoma mansoni opsin-like receptor 0.0056 0.0643 0.167
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0643 0.1347
Brugia malayi TAR-binding protein 0.0046 0.051 0.0559
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0015 0.006 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Leishmania major cytochrome p450-like protein 0.0012 0.0028 0.0028
Brugia malayi Bromodomain containing protein 0.0025 0.0214 0.0235
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.0237 0.0315
Echinococcus multilocularis 0.0012 0.0028 0.0038
Schistosoma mansoni aryl hydrocarbon receptor 0.0104 0.1328 0.345
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0093 0.0093
Leishmania major importin beta-1 subunit, putative 0.0016 0.0081 0.0081
Echinococcus multilocularis sex peptide receptor 0.0056 0.0643 0.0855
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0643 0.1347
Loa Loa (eye worm) hypothetical protein 0.0027 0.0235 0.0258
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0237 0.026
Schistosoma mansoni tar DNA-binding protein 0.0046 0.051 0.1324
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0028 0.0028
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.2166
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0135 0.0135
Brugia malayi Dopamine receptor protein 2 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.026
Onchocerca volvulus 0.0056 0.0643 0.1446
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0643 0.0855
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0643 0.167
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0643 0.0855
Trypanosoma cruzi squalene synthase, putative 0.0714 1 1
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0643 0.0855
Brugia malayi G-protein coupled receptor 0.0056 0.0643 0.0705
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0643 0.167
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0658 0.1708
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0441 0.0484
Onchocerca volvulus 0.0056 0.0643 0.1446
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0223 0.3015 0.8051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Onchocerca volvulus 0.0056 0.0643 0.1446
Brugia malayi Serotonin receptor 0.0056 0.0643 0.0705
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0237 0.0616
Toxoplasma gondii cathepsin B 0.0019 0.0118 0.1075
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Schistosoma mansoni calpain C (C02 family) 0.0017 0.0093 0.0241
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0033 0.0323 0.0354
Brugia malayi larval opioid receptor 0.0056 0.0643 0.0705
Plasmodium falciparum importin beta, putative 0.002 0.0135 0.5686
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.006 0.008
Leishmania major GTP-binding protein, putative 0.0015 0.006 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2294 1
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0643 0.1347
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0643 0.0855
Onchocerca volvulus 0.0056 0.0643 0.1446
Schistosoma mansoni cpg binding protein 0.0021 0.0157 0.0407
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0658 0.1708
Echinococcus multilocularis snurportin 1 0.0213 0.2874 0.3822
Brugia malayi cathepsin B-like cysteine proteinase 0.0057 0.0658 0.0721
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0237 0.0315
Echinococcus granulosus calpain 0.0017 0.0093 0.0195
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0643 0.0855
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0346 0.4771 0.6345
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0643 0.1347
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0235 0.0235
Schistosoma mansoni Mername-AA248 (C02 family) 0.0017 0.0093 0.0241
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0643 0.0855
Loa Loa (eye worm) serotonin transporter b 0.016 0.2122 0.2327
Entamoeba histolytica hypothetical protein 0.0016 0.0081 0.0177
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0093 0.0093
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0643 0.0705
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.2166
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0643 0.1347
Leishmania major cytochrome p450-like protein 0.0012 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0235 0.0235
Loa Loa (eye worm) RNA binding protein 0.0046 0.051 0.0559
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Brugia malayi G-protein coupled receptor 0.0056 0.0643 0.0705
Schistosoma mansoni biogenic amine receptor 0.0056 0.0643 0.167
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0643 0.0855
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0643 0.0855
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0237 1
Schistosoma mansoni hypothetical protein 0.0014 0.0047 0.0122
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0235 0.0785
Schistosoma mansoni amine GPCR 0.0056 0.0643 0.167
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0254 0.3463 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0039 0.0408 0.0855
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0237 0.0616
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0237 0.0616
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0019 0.0118 0.0118
Echinococcus multilocularis serotonin transporter 0.016 0.2122 0.2822
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0643 0.1347
Schistosoma mansoni methyl-cpg binding protein mbd 0.0011 0.0013 0.0034
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Onchocerca volvulus 0.0056 0.0643 0.1446
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0539 0.7519 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0011 0.0013 0.0034
Brugia malayi Cytochrome P450 family protein 0.0012 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis serotonin receptor 0.0056 0.0643 0.0855
Onchocerca volvulus 0.0027 0.0237 0.0317
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0028 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2294 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0235 0.0313
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Schistosoma mansoni cpg binding protein 0.0019 0.0123 0.032
Onchocerca volvulus 0.0056 0.0643 0.1446
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0643 0.0855
Echinococcus multilocularis somatostatin receptor 0.0056 0.0643 0.0855
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.007 0.0841 0.0922
Echinococcus granulosus Squalene phytoene synthase 0.0223 0.3015 0.6319
Onchocerca volvulus 0.0027 0.0235 0.0312
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus granulosus snurportin 1 0.0213 0.2874 0.6023
Brugia malayi jmjC domain containing protein 0.0041 0.0441 0.0484
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0432 0.0574
Brugia malayi putative neuropeptide receptor 0.0056 0.0643 0.0705
Schistosoma mansoni amine GPCR 0.0056 0.0643 0.167
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0093 0.0093
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0081 0.0095
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0237 0.0616
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.026
Echinococcus multilocularis calpain 7 (C02 family) 0.0017 0.0093 0.0124
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0643 0.0855
Giardia lamblia Cathepsin B precursor 0.0019 0.0118 0.0169
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0441 0.1146
Trichomonas vaginalis glucosylceramidase, putative 0.0113 0.1454 0.6241
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0643 0.1347
Schistosoma mansoni bromodomain containing protein 0.0043 0.0466 0.1209
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0643 0.0855
Giardia lamblia Cathepsin B precursor 0.0019 0.0118 0.0169
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus granulosus neuropeptide receptor 0.0056 0.0643 0.1347
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0047 0.052 0.0692
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0643 0.1347
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0643 0.1347
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni single-minded 0.0104 0.1328 0.345
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Entamoeba histolytica Ran family GTPase 0.0015 0.006 0.0115
Schistosoma mansoni hypothetical protein 0.0173 0.2312 0.6005
Schistosoma mansoni hypothetical protein 0.0056 0.0643 0.167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Loa Loa (eye worm) hypothetical protein 0.0057 0.0658 0.0721
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0237 0.0497
Schistosoma mansoni cytochrome P450 0.0012 0.0028 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0643 0.0705
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0643 0.167
Brugia malayi cytochrome P450 0.0012 0.0028 0.0031
Onchocerca volvulus 0.0056 0.0643 0.1446
Plasmodium vivax amine transporter, putative 0.0027 0.0237 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0643 0.0705
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0093 0.0093
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0643 0.0705
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.004 0.0419 0.0459
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Trichomonas vaginalis glucosylceramidase, putative 0.0113 0.1454 0.6241
Onchocerca volvulus 0.0028 0.025 0.0353
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0643 0.167
Brugia malayi ORL1-like opioid receptor 0.0056 0.0643 0.0705
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0024 0.0191 0.0255
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0237 0.0497
Brugia malayi Dopamine receptor protein 1 0.0056 0.0643 0.0705
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0643 0.1347
Echinococcus granulosus serotonin transporter 0.016 0.2122 0.4447
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.0074
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0165 0.0181
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Loa Loa (eye worm) hypothetical protein 0.007 0.0841 0.0922
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0047 0.052 0.1351
Trichomonas vaginalis importin beta-1, putative 0.0016 0.0081 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0643 0.1347
Onchocerca volvulus 0.0077 0.0944 0.2286
Schistosoma mansoni histamine h1 receptor 0.0056 0.0643 0.167
Trichomonas vaginalis glucosylceramidase, putative 0.0113 0.1454 0.6241
Onchocerca volvulus 0.0056 0.0643 0.1446
Trypanosoma cruzi phytoene synthase, putative 0.0223 0.3015 0.3015
Echinococcus granulosus orexin receptor type 2 0.0056 0.0643 0.1347
Onchocerca volvulus 0.0056 0.0643 0.1446
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0643 0.0705
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.006 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0019 0.0118 0.0258
Schistosoma mansoni cpg binding protein 0.0021 0.0157 0.0407
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0643 0.0855
Schistosoma mansoni sodium/chloride dependent transporter 0.016 0.2122 0.5511
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Brugia malayi hypothetical protein 0.0027 0.0237 0.026
Trypanosoma cruzi kinesin, putative 0.0012 0.002 0.002
Brugia malayi Dopamine receptor 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0028 0.025 0.0274
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis cathepsin b 0.0057 0.0658 0.0874
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0028 0.0031
Brugia malayi MH2 domain containing protein 0.0102 0.1295 0.1421
Echinococcus multilocularis hypothetical protein 0.0017 0.0093 0.0124
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.0237 0.0497
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0028 0.006
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0643 0.1347
Brugia malayi RE15519p 0.0056 0.0643 0.0705
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0237 0.0497
Echinococcus granulosus fmrfamide receptor 0.0056 0.0643 0.1347
Schistosoma mansoni hypothetical protein 0.0223 0.3015 0.7831
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0643 0.1347
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0643 0.167
Echinococcus granulosus fetal alzheimer antigen falz 0.0016 0.008 0.0168
Schistosoma mansoni hypothetical protein 0.0056 0.0643 0.167
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0015 0.006 0.0549
Schistosoma mansoni amine GPCR 0.0056 0.0643 0.167
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0643 0.167
Toxoplasma gondii histone lysine methyltransferase SET1 0.0038 0.0389 0.3551
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0028 0.0031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.3866 0.4241
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0028 0.0031
Schistosoma mansoni hypothetical protein 0.0048 0.0528 0.1371
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.006 0.006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0658 0.1708
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0643 0.167
Trichomonas vaginalis glucosylceramidase, putative 0.0113 0.1454 0.6241
Trypanosoma brucei cysteine peptidase C (CPC) 0.0019 0.0118 0.0118
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0047 0.052 0.109
Brugia malayi calpain 5 0.0012 0.002 0.0022
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0237 0.0616
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0046 0.051 0.0559
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0643 0.0705
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0643 0.1347
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0235 0.0785
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0237 0.0616
Loa Loa (eye worm) PHD-finger family protein 0.0014 0.0047 0.0051
Toxoplasma gondii HEAT repeat-containing protein 0.002 0.0135 0.1232
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2294 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Trichomonas vaginalis glucosylceramidase, putative 0.0119 0.154 0.6627
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0017 0.0093 0.0093
Echinococcus multilocularis cpg binding protein 0.0021 0.0157 0.0209
Onchocerca volvulus 0.0027 0.0237 0.0317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0643 0.0705
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0643 0.0705
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0235 0.0313
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.006 0.006
Brugia malayi Bromodomain containing protein 0.0051 0.0576 0.0632
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Echinococcus granulosus GPCR family 2 0.0022 0.0165 0.0345
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0337 0.4637 0.5086
Schistosoma mansoni neuropeptide receptor 0.0056 0.0643 0.167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0643 0.0855
Echinococcus granulosus zinc finger protein 0.0014 0.0052 0.011
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0028 0.026
Echinococcus granulosus histone lysine methyltransferase setb 0.0012 0.0019 0.004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0491 0.1276
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0441 0.0925
Treponema pallidum sodium- and chloride- dependent transporter 0.016 0.2122 0.5
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0237 0.0616
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0012 0.0019 0.0049
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0028 0.0028
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0643 0.167
Trypanosoma cruzi importin beta-1 subunit, putative 0.0016 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.016 0.2122 0.2327
Onchocerca volvulus 0.0272 0.3715 1
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0643 0.0855
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0135 0.0135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0428 0.1111
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0223 0.3015 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0165 0.0345
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0643 0.0855
Giardia lamblia DNA repair protein RAD52 0.0254 0.3463 1
Echinococcus granulosus calpain 5 0.0017 0.0093 0.0195
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0057 0.0658 0.1708
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus granulosus hypothetical protein 0.0056 0.0643 0.1347
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0643 0.0855
Echinococcus granulosus allatostatin A receptor 0.0056 0.0643 0.1347
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0093 0.0093
Echinococcus granulosus sex peptide receptor 0.0056 0.0643 0.1347
Mycobacterium leprae Possible regulatory protein 0.0027 0.0235 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.016 0.2122 0.5511
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 0.1295 0.1421
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0034 0.0045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0165 0.0345
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni neuropeptide receptor 0.0056 0.0643 0.167
Echinococcus granulosus single minded 2 0.0077 0.0944 0.1979
Brugia malayi bHLH-PAS transcription factor 0.0077 0.0944 0.1036
Giardia lamblia Cathepsin B precursor 0.0019 0.0118 0.0169
Brugia malayi hypoxia-induced factor 1 0.0321 0.4421 0.485
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0643 0.167
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0643 0.1347
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0643 0.1347
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0643 0.1347
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0016 0.008 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0235 0.0785
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0643 0.0855
Echinococcus granulosus methyl CpG binding domain protein 2 0.0011 0.0013 0.0027
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0039 0.0408 0.0542
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0237 0.0616
Onchocerca volvulus 0.0027 0.0237 0.0317
Schistosoma mansoni opsin-like receptor 0.0056 0.0643 0.167
Leishmania major protein kinase, putative 0.0027 0.0235 0.0235
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.006 0.0126
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0012 0.0028 0.0028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0165 0.0219
Onchocerca volvulus 0.0056 0.0643 0.1446
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0643 0.1347
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0237 0.0315
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0235 0.0493
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0643 0.0855
Trypanosoma brucei kinesin, putative 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0643 0.167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0643 0.167
Schistosoma mansoni tar DNA-binding protein 0.0046 0.051 0.1324
Schistosoma mansoni ran 0.0015 0.006 0.0156
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0346 0.4771 1
Brugia malayi sulfakinin receptor protein 0.0056 0.0643 0.0705
Echinococcus multilocularis importin subunit beta 1 0.002 0.0135 0.0179
Brugia malayi hypothetical protein 0.0272 0.3715 0.4075
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0643 0.1347
Echinococcus multilocularis calpain A 0.0047 0.052 0.0692
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0643 0.0855
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0643 0.1347
Schistosoma mansoni amine GPCR 0.0056 0.0643 0.167
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0235 0.0785
Echinococcus granulosus amiloride sensitive amine oxidase 0.0173 0.2312 0.4845
Echinococcus granulosus somatostatin receptor 0.0056 0.0643 0.1347
Brugia malayi calpain family protein 1 0.0045 0.0491 0.0539
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0643 0.1347
Brugia malayi CXXC zinc finger family protein 0.0019 0.0123 0.0135
Brugia malayi calpain family protein 1 0.0045 0.0491 0.0539
Loa Loa (eye worm) hypothetical protein 0.0333 0.4587 0.5032
Brugia malayi follicle stimulating hormone receptor 0.0282 0.3866 0.4241
Schistosoma mansoni zinc finger protein 0.0014 0.0052 0.0136
Brugia malayi Cytochrome P450 family protein 0.0012 0.0028 0.0031
Loa Loa (eye worm) transcription factor SMAD2 0.0102 0.1295 0.1421
Loa Loa (eye worm) solute carrier family 6 member 4 0.016 0.2122 0.2327
Onchocerca volvulus 0.0056 0.0643 0.1446
Echinococcus granulosus g protein coupled receptor 0.0056 0.0643 0.1347
Echinococcus multilocularis jun protein 0.0346 0.4771 0.6345
Echinococcus granulosus cpg binding protein 0.0021 0.0157 0.0329
Schistosoma mansoni hypothetical protein 0.0022 0.0165 0.0428
Onchocerca volvulus 0.0056 0.0643 0.1446
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0235 0.0785
Echinococcus multilocularis Squalene phytoene synthase 0.0223 0.3015 0.4009
Echinococcus multilocularis serotonin receptor 0.0056 0.0643 0.0855
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0643 0.1347
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0643 0.0855
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0015 0.006 0.2533
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0237 0.026
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0643 0.0855
Brugia malayi RNA, U transporter 1 0.0057 0.0657 0.072
Schistosoma mansoni biogenic amine receptor 0.0056 0.0643 0.167
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0643 0.1446
Schistosoma mansoni tar DNA-binding protein 0.0046 0.051 0.1324
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0643 0.0855
Schistosoma mansoni calpain-7 (C02 family) 0.0017 0.0093 0.0241
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0237 0.0497
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0235 0.0785
Echinococcus multilocularis tar DNA binding protein 0.0046 0.051 0.0678
Loa Loa (eye worm) hypothetical protein 0.016 0.2122 0.2327
Plasmodium vivax calpain, putative 0.0017 0.0093 0.3921
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0643 0.0705
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Brugia malayi RNA recognition motif domain containing protein 0.0046 0.051 0.0559
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0643 0.1347
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0643 0.0855
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0643 0.0855
Echinococcus multilocularis calpain 5 0.0017 0.0093 0.0124
Brugia malayi G protein-coupled receptor 0.0056 0.0643 0.0705
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0213 0.2874 0.3153
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0441 0.1146
Echinococcus granulosus cathepsin b 0.0057 0.0658 0.1378
Schistosoma mansoni biogenic amine receptor 0.0056 0.0643 0.167
Schistosoma mansoni tar DNA-binding protein 0.0046 0.051 0.1324
Schistosoma mansoni hypothetical protein 0.0022 0.0165 0.0428
Loa Loa (eye worm) hypothetical protein 0.0022 0.0165 0.0181
Loa Loa (eye worm) hypothetical protein 0.0027 0.0237 0.026
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0235 0.0785
Trichomonas vaginalis glucosylceramidase, putative 0.0113 0.1454 0.6241
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0235 0.0235
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0237 0.0497
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0643 0.167
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0643 0.0855
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0643 0.0705
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2294 1
Loa Loa (eye worm) bromodomain containing protein 0.0012 0.0019 0.0021
Brugia malayi hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni hypothetical protein 0.0056 0.0643 0.167
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0017 0.0093 0.0093
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Trypanosoma cruzi squalene synthase, putative 0.0714 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.016 0.2122 0.2327
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0019 0.0118 0.0306
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0017 0.0093 0.0093
Brugia malayi Importin beta-1 subunit 0.002 0.0135 0.0148
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0237 0.0616
Brugia malayi hypothetical protein 0.0348 0.4805 0.5271
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0643 0.0855
Schistosoma mansoni amine GPCR 0.0056 0.0643 0.167
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0643 0.167
Trypanosoma brucei antigen, putative 0.0017 0.0093 0.0093
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0235 0.0785
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0237 0.0315
Echinococcus granulosus neuropeptide receptor 0.0056 0.0643 0.1347
Loa Loa (eye worm) calpain 0.0017 0.0093 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0113 0.1454 0.6241
Loa Loa (eye worm) hypothetical protein 0.0223 0.3015 0.3307
Schistosoma mansoni calpain (C02 family) 0.0017 0.0093 0.0241
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0173 0.2312 0.3074
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus granulosus jun protein 0.0346 0.4771 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.052 0.0571
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0235 0.0235
Loa Loa (eye worm) TAR-binding protein 0.0046 0.051 0.0559
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0165 0.0219
Trypanosoma brucei calpain-like protein, putative 0.0017 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni hypothetical protein 0.0213 0.2874 0.7465
Leishmania major kinesin, putative 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0237 0.0315
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0643 0.0855
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0019 0.0118 0.0118
Entamoeba histolytica hypothetical protein 0.0072 0.0879 0.2495
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0643 0.1347
Onchocerca volvulus 0.0056 0.0643 0.1446
Trypanosoma brucei squalene synthase, putative 0.0714 1 1
Brugia malayi Cytochrome P450 family protein 0.0012 0.0028 0.0031
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0643 0.0855
Plasmodium vivax importin-beta 2, putative 0.002 0.0135 0.5686
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0643 0.1347
Schistosoma mansoni neuropeptide receptor 0.0056 0.0643 0.167
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0643 0.167
Brugia malayi GnHR receptor homolog 0.0056 0.0643 0.0705
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0017 0.0093 0.0093
Loa Loa (eye worm) hypoxia-induced factor 1 0.0321 0.4421 0.485
Loa Loa (eye worm) hypothetical protein 0.0056 0.0643 0.0705
Schistosoma mansoni adenoreceptor 0.0056 0.0643 0.167

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 19 % Inhibitory activity against HIV-1 reverse transcriptase (wild type) at 10 microM dose ChEMBL. 9748354
Inhibition (binding) = 19 % Inhibitory activity against HIV-1 reverse transcriptase (wild type) at 10 microM dose ChEMBL. 9748354
Inhibition (binding) = 25 % Inhibitory activity against HIV-1 reverse transcriptase (P236L) at 10 microM dose ChEMBL. 9748354
Inhibition (binding) = 25 % Inhibitory activity against HIV-1 reverse transcriptase (P236L) at 10 microM dose ChEMBL. 9748354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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