Detailed information for compound 219797

Basic information

Technical information
  • TDR Targets ID: 219797
  • Name: N,N-diethyl-4-[phenyl(piperazin-1-yl)methyl]b enzamide
  • MW: 351.485 | Formula: C22H29N3O
  • H donors: 1 H acceptors: 1 LogP: 2.99 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1ccc(cc1)C(c1ccccc1)N1CCNCC1)CC
  • InChi: 1S/C22H29N3O/c1-3-24(4-2)22(26)20-12-10-19(11-13-20)21(18-8-6-5-7-9-18)25-16-14-23-15-17-25/h5-13,21,23H,3-4,14-17H2,1-2H3
  • InChiKey: SGSNUYVZXCAQRH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-diethyl-4-[phenyl(1-piperazinyl)methyl]benzamide
  • N,N-diethyl-4-[phenyl(piperazino)methyl]benzamide
  • N,N-diethyl-4-(phenyl-piperazin-1-ylmethyl)benzamide
  • N,N-diethyl-4-(phenyl-piperazin-1-yl-methyl)benzamide
  • N,N-diethyl-4-[phenyl-(1-piperazinyl)methyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0206 0.0206
Onchocerca volvulus 0.0073 0.0206 0.201
Schistosoma mansoni amine GPCR 0.0073 0.0206 0.0206
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0079 0.0079
Brugia malayi fibroinase precursor 0.0033 0.0049 0.0049
Trypanosoma brucei squalene synthase, putative 0.0234 0.0839 0.0827
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2572 1 1
Plasmodium vivax SET domain protein, putative 0.0036 0.006 0.0042
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0206 0.0206
Brugia malayi Cathepsin L-like precursor 0.0178 0.0618 0.0618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0092 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi cytochrome P450 0.0023 0.0012 0.0012
Brugia malayi ORL1-like opioid receptor 0.0073 0.0206 0.0206
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0092 0.028 0.028
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Brugia malayi AKH receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0033 0.0049 0.0037
Trypanosoma cruzi major cysteine proteinase, putative 0.0533 0.2009 0.1999
Echinococcus granulosus neuropeptide receptor 0.0073 0.0206 0.0206
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0033 0.0049 0.0049
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0033 0.0049 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0206 0.0206
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0742 0.2827 0.2827
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0075 0.0731
Onchocerca volvulus 0.0073 0.0206 0.201
Echinococcus granulosus allatostatin A receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 0.0206 0.0206
Trypanosoma cruzi cruzipain precursor, putative 0.0678 0.2578 0.2568
Onchocerca volvulus Cathepsin F homolog 0.0178 0.0618 0.6021
Onchocerca volvulus 0.0178 0.0618 0.6021
Plasmodium vivax unspecified product 0.0092 0.028 0.0262
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 0.0206 0.0206
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0018 0.0006
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0679 0.2583 0.2583
Brugia malayi Cathepsin L-like precursor 0.0178 0.0618 0.0618
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.2572 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0033 0.0049 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.0178 0.0618 0.0606
Loa Loa (eye worm) polyprenyl synthetase 0.0679 0.2583 0.2583
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0033 0.0049 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Echinococcus granulosus cathepsin L 0.0033 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0079 0.0067
Leishmania major squalene synthase, putative 0.0234 0.0839 0.0827
Echinococcus multilocularis neuropeptide receptor A26 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine protease, putative 0.0178 0.0618 0.2245
Schistosoma mansoni neuropeptide receptor 0.0073 0.0206 0.0206
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.2572 1 1
Plasmodium vivax glutathione reductase, putative 0.0049 0.0112 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0178 0.0618 0.059
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0033 0.0049 0.0031
Echinococcus multilocularis GPCR, family 3, C terminal 0.0021 0.0003 0.0003
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0206 0.0206
Onchocerca volvulus 0.0073 0.0206 0.201
Leishmania major cathepsin L-like protease 0.0678 0.2578 0.2568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0678 0.2578 0.2568
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0206 0.0206
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 0.0206 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0092 0.028 0.0268
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0075 0.0214 0.0214
Brugia malayi Receptor family ligand binding region containing protein 0.0148 0.0502 0.0502
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 0.0206 0.0206
Echinococcus multilocularis g-protein coupled receptor 0.0073 0.0206 0.0206
Leishmania major hypothetical protein, conserved 0.0073 0.0207 0.0195
Leishmania major polyprenyl synthase, putative 0.0742 0.2827 0.2818
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0104 0.0328 0.0328
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Echinococcus granulosus cathepsin l1 0.0119 0.0387 0.0387
Echinococcus multilocularis cathepsin b 0.0033 0.0049 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0021 0.0003 0.0027
Brugia malayi Dopamine receptor protein 1 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0049 0.0019
Brugia malayi cathepsin Z-like cysteine proteinase 0.0033 0.0049 0.0049
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0087 0.0845
Loa Loa (eye worm) hypothetical protein 0.0021 0.0003 0.0003
Brugia malayi hypothetical protein 0.0025 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0206 0.0206
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0033 0.0049 0.0049
Brugia malayi G protein-coupled receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0033 0.0049 0.0049
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 0.0206 0.0206
Echinococcus multilocularis sex peptide receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0087 0.0057
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0049 0.0049
Schistosoma mansoni cathepsin B (C01 family) 0.0033 0.0049 0.0049
Echinococcus multilocularis cathepsin L 0.0033 0.0049 0.0049
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Trypanosoma brucei glucosidase, putative 0.0041 0.0079 0.0067
Trypanosoma brucei farnesyl pyrophosphate synthase 0.2572 1 1
Schistosoma mansoni amine GPCR 0.0073 0.0206 0.0206
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0743 0.2834 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 0.0206 0.0206
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0206 0.0206
Brugia malayi Dopamine receptor 0.0073 0.0206 0.0206
Echinococcus granulosus metabotropic glutamate receptor 2 0.0066 0.018 0.018
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.006 0.006
Onchocerca volvulus 0.0073 0.0206 0.201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.028 0.0251
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0018 0.0006
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.2572 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0049 0.0019
Entamoeba histolytica cysteine proteinase 1, putative 0.0092 0.028 0.091
Schistosoma mansoni amine GPCR 0.0073 0.0206 0.0206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0072 0.0043
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Leishmania major cytochrome p450-like protein 0.0042 0.0084 0.0072
Brugia malayi cathepsin L precursor 0.0033 0.0049 0.0049
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0295 0.1077 0.1077
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0066 0.018 0.018
Onchocerca volvulus 0.0073 0.0206 0.201
Trichomonas vaginalis chromobox protein, putative 0.007 0.0196 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.005
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0206 0.0206
Brugia malayi Heterochromatin protein 1 0.007 0.0196 0.0196
Brugia malayi follicle stimulating hormone receptor 0.0295 0.1077 0.1077
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0742 0.2827 0.2827
Brugia malayi Cytochrome P450 family protein 0.0042 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Melatonin receptor type 1A 0.0073 0.0206 0.0206
Leishmania major cathepsin L-like protease 0.0178 0.0618 0.0606
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0079 0.005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Plasmodium falciparum serine repeat antigen 5 0.0033 0.0049 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0206 0.0206
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 0.0206 0.0206
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Toxoplasma gondii cathepsin CPL 0.0178 0.0618 0.0606
Plasmodium falciparum serine repeat antigen 6 0.0033 0.0049 0.0031
Onchocerca volvulus 0.0178 0.0618 0.6021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0018
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 0.0206 0.0206
Echinococcus granulosus farnesyl pyrophosphate synthase 0.2572 1 1
Echinococcus granulosus cathepsin L 0.0092 0.028 0.028
Loa Loa (eye worm) glutamate receptor 0.0038 0.0069 0.0069
Brugia malayi RE15519p 0.0073 0.0206 0.0206
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0679 0.2583 0.2573
Brugia malayi G-protein coupled receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.005
Schistosoma mansoni farnesyl pyrophosphate synthase 0.2572 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 0.0206 0.0206
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0089 0.0089
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.2572 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0178 0.0618 0.0601
Plasmodium falciparum glutathione reductase 0.0049 0.0112 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0049 0.0019
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.0637 0.0637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0049 0.0019
Brugia malayi larval opioid receptor 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine proteinase, putative 0.0178 0.0618 0.2245
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis chromobox protein, putative 0.007 0.0196 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0049 0.0019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Onchocerca volvulus 0.0031 0.0042 0.0405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0049 0.0019
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0206 0.0206
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 0.0206 0.0206
Onchocerca volvulus 0.0119 0.0387 0.3775
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0098 0.0098
Onchocerca volvulus 0.0073 0.0206 0.201
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0089 0.0077
Leishmania major cathepsin L-like protease 0.0678 0.2578 0.2568
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0049 0.0019
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0679 0.2583 0.2573
Plasmodium falciparum thioredoxin reductase 0.0049 0.0112 0.0093
Schistosoma mansoni amine GPCR 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0206 0.0206
Plasmodium vivax vivapain-2 0.0178 0.0618 0.0601
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Brugia malayi Cathepsin L-like precursor 0.0059 0.0151 0.0151
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0356 0.0344
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 0.0206 0.0206
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0679 0.2583 1
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0098 0.0098
Schistosoma mansoni adenoreceptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) cathepsin B 0.0033 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Echinococcus granulosus neuropeptide s receptor 0.0073 0.0206 0.0206
Schistosoma mansoni alpha-glucosidase 0.0157 0.0537 0.0537
Toxoplasma gondii cathepsin B 0.0033 0.0049 0.0037
Plasmodium falciparum cysteine proteinase falcipain 3 0.0178 0.0618 0.0601
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0119 0.0387 0.0387
Onchocerca volvulus 0.0282 0.1026 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0089 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0049 0.0019
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0679 0.2583 0.2573
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0679 0.2583 0.2569
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0098 0.0098
Plasmodium falciparum cysteine proteinase falcipain 1 0.0092 0.028 0.0262
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0083 0.0083
Onchocerca volvulus 0.0073 0.0206 0.201
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0151
Schistosoma mansoni ap endonuclease 0.0043 0.0089 0.0089
Echinococcus multilocularis cysteine protease 0.0178 0.0618 0.0618
Onchocerca volvulus 0.0073 0.0206 0.201
Brugia malayi Cathepsin L-like cysteine proteinase 0.0119 0.0387 0.0387
Onchocerca volvulus 0.0073 0.0206 0.201
Schistosoma mansoni alpha glucosidase 0.0041 0.0079 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0206 0.0206
Onchocerca volvulus 0.0178 0.0618 0.6021
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 0.0206 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Brugia malayi Serotonin receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0084 0.0084
Brugia malayi Thioredoxin reductase 0.0049 0.0112 0.0112
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0619 0.2347 0.2337
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0083 0.0083
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0166 0.0573 0.0561
Onchocerca volvulus 0.0073 0.0206 0.201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0092 0.028 0.028
Onchocerca volvulus 0.0178 0.0618 0.6021
Onchocerca volvulus 0.0073 0.0206 0.201
Echinococcus granulosus neuropeptide receptor A26 0.0073 0.0206 0.0206
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0033 0.0049 0.0031
Schistosoma mansoni glutathione synthetase 0.0679 0.2583 0.2583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0049 0.0019
Schistosoma mansoni hypothetical protein 0.0021 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0018 0.0006
Brugia malayi neuropeptide F receptor 0.0073 0.0206 0.0206
Onchocerca volvulus Cathepsin L homolog 0.0178 0.0618 0.6021
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0178 0.0618 0.0618
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0679 0.2583 0.2573
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0073 0.0207 0.2015
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0098 0.0098
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0018 0.0006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0049 0.0049
Brugia malayi Pre-SET motif family protein 0.0036 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0098 0.0098
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0033 0.0049 0.0049
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0742 0.2827 0.2827
Schistosoma mansoni amine GPCR 0.0073 0.0206 0.0206
Echinococcus multilocularis cathepsin b 0.0033 0.0049 0.0049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0073 0.0207 0.0207
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0178 0.0618 0.0618
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0089 0.0158
Brugia malayi Cytochrome P450 family protein 0.0067 0.0182 0.0182
Plasmodium vivax vivapain-3 0.0092 0.028 0.0262
Schistosoma mansoni chromobox protein 0.007 0.0196 0.0196
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0679 0.2583 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0049 0.0019
Leishmania major hypothetical protein, conserved 0.0025 0.0018 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0084 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0033 0.005 0.005
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0033 0.0049 0.0049
Trypanosoma cruzi squalene synthase, putative 0.0234 0.0839 0.0827
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0206 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0679 0.2583 0.2583
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.006 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0098 0.0098
Brugia malayi Papain family cysteine protease containing protein 0.0092 0.028 0.028
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 0.0206 0.0206
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.006 0.006
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0742 0.2827 0.2827
Echinococcus multilocularis chromobox protein 1 0.007 0.0196 0.0196
Echinococcus multilocularis neuropeptide FF receptor 2 0.0073 0.0206 0.0206
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2572 1 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2572 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.006 0.0047
Echinococcus granulosus chromobox protein 1 0.007 0.0196 0.0196
Plasmodium vivax serine-repeat antigen (SERA) 0.0033 0.0049 0.0031
Brugia malayi Tachykinin-like peptides receptor 99D 0.0073 0.0206 0.0206
Loa Loa (eye worm) cytochrome P450 0.0023 0.0012 0.0012
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0073 0.0206 0.201
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0049 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0112 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0098 0.0098
Plasmodium vivax serine-repeat antigen (SERA) 0.0033 0.0049 0.0031
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Echinococcus multilocularis cysteine protease 0.0178 0.0618 0.0618
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0248 0.0892 0.0892
Loa Loa (eye worm) fibroinase 0.0178 0.0618 0.0618
Loa Loa (eye worm) glutamate receptor 0.0087 0.0262 0.0262
Echinococcus granulosus metabotropic glutamate receptor 5 0.0104 0.0328 0.0328
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0089 0.0077
Plasmodium falciparum serine repeat antigen 2 0.0033 0.0049 0.0031
Onchocerca volvulus Cathepsin L homolog 0.0178 0.0618 0.6021
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0079 0.0079
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0033 0.0049 0.0031
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0679 0.2583 0.2573
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0206 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0678 0.2578 0.2568
Echinococcus granulosus g protein coupled receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0036 0.0062 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Plasmodium vivax vivapain-1 0.0092 0.028 0.0262
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0206 0.0206
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.0637 0.0637
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.005
Echinococcus granulosus sex peptide receptor 0.0073 0.0206 0.0206
Echinococcus granulosus cathepsin L cysteine protease 0.0092 0.028 0.028
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0089 0.0077
Leishmania major cathepsin L-like protease 0.0178 0.0618 0.0606
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0206 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Echinococcus multilocularis cathepsin L cysteine protease 0.0178 0.0618 0.0618
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0033 0.0049 0.0031
Schistosoma mansoni cytochrome P450 0.0023 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus G protein coupled receptor 139 0.0073 0.0206 0.0206
Schistosoma mansoni cathepsin F (C01 family) 0.0178 0.0618 0.0618
Onchocerca volvulus 0.0047 0.0105 0.1023
Onchocerca volvulus 0.0073 0.0206 0.201
Echinococcus granulosus Squalene phytoene synthase 0.0073 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0073 0.0207 0.0207
Trypanosoma cruzi polyprenyl synthase, putative 0.0742 0.2827 0.2818
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2572 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0387 0.0359
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0148 0.0502 0.0502
Brugia malayi G-protein coupled receptor 0.0073 0.0206 0.0206
Echinococcus granulosus cathepsin l cysteine peptidase 0.0178 0.0618 0.0618
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0033 0.0049 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus fmrfamide receptor 0.0073 0.0206 0.0206
Toxoplasma gondii cathepsin CPC2 0.0033 0.0049 0.0037
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0033 0.0049 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.1323 0.5105 0.5105
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0075 0.0045
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0178 0.0618 0.0618
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.0637 0.0637
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.2572 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Leishmania major cathepsin L-like protease 0.0678 0.2578 0.2568
Echinococcus granulosus hypothetical protein 0.0073 0.0206 0.0206
Trypanosoma cruzi cysteine proteinase, putative 0.0092 0.028 0.0268
Brugia malayi neuropeptide F receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0089 0.0089
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0084 0.0084
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 0.0206 0.0206
Echinococcus granulosus chromobox protein 1 0.007 0.0196 0.0196
Plasmodium vivax vivapain-2 0.0178 0.0618 0.0601
Schistosoma mansoni neuropeptide receptor 0.0073 0.0206 0.0206
Echinococcus granulosus serotonin receptor 0.0073 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0083 0.0083
Trypanosoma cruzi squalene synthase, putative 0.0234 0.0839 0.0827
Echinococcus multilocularis orexin receptor type 2 0.0073 0.0206 0.0206
Schistosoma mansoni cathepsin F (C01 family) 0.0178 0.0618 0.0618
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0033 0.0049 0.0037
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.0637 0.0637
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0405 0.1526
Loa Loa (eye worm) hypothetical protein 0.0119 0.0387 0.0387
Echinococcus granulosus g protein coupled receptor 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine proteinase 2 0.0092 0.028 0.091
Echinococcus granulosus g protein coupled receptor 0.0073 0.0206 0.0206
Toxoplasma gondii thioredoxin reductase 0.0049 0.0112 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus cathepsin L cysteine proteinase 0.0178 0.0618 0.0618
Echinococcus multilocularis serotonin receptor 0.0073 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Schistosoma mansoni cathepsin F (C01 family) 0.0119 0.0387 0.0387
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0079 0.005
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0087 0.0057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Trichomonas vaginalis set domain proteins, putative 0.0282 0.1026 0.0999
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Echinococcus multilocularis somatostatin receptor 0.0073 0.0206 0.0206
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0206 0.0206
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0092 0.028 0.028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Loa Loa (eye worm) glutathione reductase 0.0049 0.0112 0.0112
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0405 0.0393
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Polyprenyl synthetase family protein 0.0679 0.2583 0.2583
Brugia malayi cathepsin Z-like cysteine proteinase 0.0033 0.0049 0.0049
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0033 0.0049 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0049 0.0019
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus cathepsin b 0.0033 0.0049 0.0049
Onchocerca volvulus 0.0073 0.0206 0.201
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0679 0.2583 0.2583
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 0.0206 0.0206
Leishmania major trypanothione reductase 0.0049 0.0112 0.0099
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0679 0.2583 0.2583
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0742 0.2827 0.2827
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0092 0.028 0.0268
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Cathepsin L-like precursor 0.0178 0.0618 0.0618
Schistosoma mansoni hypothetical protein 0.0073 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0092 0.028 0.0268
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0079 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Brugia malayi Papain family cysteine protease containing protein 0.0178 0.0618 0.0618
Trypanosoma cruzi cysteine protease, putative 0.0092 0.028 0.0268
Brugia malayi Cytochrome P450 family protein 0.0042 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.028 0.0251
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Dopamine receptor protein 2 0.0073 0.0206 0.0206
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0059 0.0151 0.0151
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine proteinase, putative 0.0178 0.0618 0.2245
Onchocerca volvulus Poor gastrulation protein homolog 0.0021 0.0003 0.0027
Loa Loa (eye worm) ctsf protein 0.0178 0.0618 0.0618
Echinococcus multilocularis chromobox protein 1 0.007 0.0196 0.0196
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0206 0.0206
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Schistosoma mansoni ap endonuclease 0.0043 0.0089 0.0089
Onchocerca volvulus 0.0033 0.0049 0.048
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 0.0206 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.006 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Giardia lamblia Farnesyl diphosphate synthase 0.2572 1 1
Mycobacterium ulcerans epoxide hydrolase EphA 0.0166 0.0573 0.0561
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.2572 1 1
Schistosoma mansoni biogenic amine receptor 0.0073 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0049 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0049 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0206 0.0206
Echinococcus granulosus orexin receptor type 2 0.0073 0.0206 0.0206
Loa Loa (eye worm) TYRA-2 protein 0.0073 0.0206 0.0206
Plasmodium vivax unspecified product 0.0033 0.0049 0.0031
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0084 0.0072
Toxoplasma gondii preprocathepsin c precursor, putative 0.0033 0.0049 0.0037
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0679 0.2583 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0098 0.0098
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0112 0.0112
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0112 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Brugia malayi chromobox protein homolog 3 0.0039 0.0075 0.0075
Loa Loa (eye worm) cysteine protease 0.0178 0.0618 0.0618
Schistosoma mansoni cathepsin S (C01 family) 0.0033 0.0049 0.0049
Schistosoma mansoni opsin-like receptor 0.0073 0.0206 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0079 0.0067
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0084 0.0072
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0073 0.0207 0.0195
Echinococcus granulosus neuropeptide FF receptor 2 0.0073 0.0206 0.0206
Echinococcus granulosus cathepsin l1 0.0178 0.0618 0.0618
Onchocerca volvulus 0.0106 0.0335 0.3261
Trypanosoma cruzi cysteine peptidase, putative 0.0178 0.0618 0.0606
Echinococcus multilocularis G protein coupled receptor 139 0.0073 0.0206 0.0206
Trypanosoma cruzi cysteine proteinase, putative 0.0092 0.028 0.0268
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0089 0.006
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0112 0.0093
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.028 0.091
Echinococcus multilocularis 0.0023 0.0012 0.0012
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.2572 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0196 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0033 0.0049 0.0019
Echinococcus multilocularis serotonin receptor 0.0073 0.0206 0.0206
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 0.0206 0.0206
Brugia malayi putative neuropeptide receptor 0.0073 0.0206 0.0206
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 0.0206 0.0206
Trypanosoma brucei trypanothione reductase 0.0049 0.0112 0.0099
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0206 0.0206
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0356 0.1337
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0033 0.0049 0.0031
Onchocerca volvulus 0.0073 0.0206 0.201
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0743 0.2834 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0151
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0033 0.0049 0.0031
Onchocerca volvulus Neuropeptide F receptor homolog 0.0073 0.0206 0.201
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.028 0.091
Brugia malayi Cathepsin L-like precursor 0.0178 0.0618 0.0618
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0206 0.0206
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0743 0.2834 0.2825
Mycobacterium ulcerans phytoene synthase, CrtB 0.0073 0.0207 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus multilocularis allatostatin A receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0083 0.0083
Echinococcus multilocularis Squalene phytoene synthase 0.0073 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0033 0.0049 0.0019
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Cytochrome P450 family protein 0.0023 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 0.0206 0.0206
Brugia malayi Metabotropic glutamate receptor precursor. 0.0087 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0119 0.0387 0.0387
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0679 0.2583 1
Onchocerca volvulus 0.0073 0.0206 0.201
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0405 0.0393
Schistosoma mansoni cathepsin C 0.0033 0.0049 0.0049
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0079 0.0079
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0079 0.0119
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0178 0.0618 0.059
Plasmodium falciparum serine repeat antigen 1 0.0033 0.0049 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0206 0.0206
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0679 0.2583 0.9084
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0089 0.0077
Onchocerca volvulus 0.0178 0.0618 0.6021
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0021 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.006
Plasmodium falciparum serine repeat antigen 8 0.0033 0.0049 0.0031
Toxoplasma gondii exonuclease III APE 0.0043 0.0089 0.0077
Brugia malayi glutathione reductase 0.0049 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus multilocularis cathepsin L 0.0092 0.028 0.028
Echinococcus granulosus neuropeptide receptor 0.0073 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Trypanosoma cruzi major cysteine proteinase, putative 0.0033 0.0049 0.0037
Brugia malayi Pre-SET motif family protein 0.0248 0.0892 0.0892
Leishmania major farnesyl pyrophosphate synthase 0.2572 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0059 0.0151 0.0151
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0089 0.0071
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0112 0.0099
Brugia malayi Cathepsin L-like precursor 0.0178 0.0618 0.0618
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0743 0.2834 0.2825
Echinococcus granulosus cytochrome P450 2K1 0.0023 0.0012 0.0012
Plasmodium vivax unspecified product 0.0059 0.0151 0.0133
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0079 0.0119
Plasmodium falciparum serine repeat antigen 4 0.0033 0.0049 0.0031
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Treponema pallidum octaprenyl-diphosphate synthase 0.0742 0.2827 1
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus dro:myosuppressin receptor 0.0073 0.0206 0.0206
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 0.0206 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0089 0.006
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0033 0.0049 0.0049
Schistosoma mansoni metabotropic glutamate receptor 0.005 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0059 0.0151 0.0151
Brugia malayi MH2 domain containing protein 0.0116 0.0377 0.0377
Leishmania major solanesyl-diphosphate synthase, putative 0.0679 0.2583 0.2573
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0089 0.0089
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0104 0.0328 0.0328
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0743 0.2834 0.2825
Schistosoma mansoni neuropeptide receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0151 0.0151
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0679 0.2583 0.2573
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0084 0.0072
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 0.0206 0.0206
Schistosoma mansoni histamine h1 receptor 0.0073 0.0206 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0178 0.0618 0.0618
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0089 0.0089
Brugia malayi Cathepsin L-like precursor 0.0178 0.0618 0.0618
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.0178 0.0618 0.0606
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0679 0.2583 0.2573
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0178 0.0618 0.0601
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Brugia malayi Cathepsin L-like precursor 0.0119 0.0387 0.0387
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0206 0.0206
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0679 0.2583 0.2569
Brugia malayi Cathepsin L-like precursor 0.0119 0.0387 0.0387
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0079 0.0067
Onchocerca volvulus 0.0073 0.0206 0.201
Onchocerca volvulus 0.0178 0.0618 0.6021
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0072 0.0043
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0206 0.0206
Brugia malayi sulfakinin receptor protein 0.0073 0.0206 0.0206
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0206 0.0206
Onchocerca volvulus 0.0178 0.0618 0.6021
Schistosoma mansoni alpha-glucosidase 0.0157 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0033 0.0049 0.0049
Schistosoma mansoni neuropeptide receptor 0.0073 0.0206 0.0206
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0098 0.0098
Toxoplasma gondii cathepsin CPC1 0.0033 0.0049 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0098 0.0098
Leishmania major cysteine peptidase A (CPA) 0.0178 0.0618 0.0606
Brugia malayi cathepsin L-like cysteine proteinase 0.0033 0.0049 0.0049
Trypanosoma cruzi phytoene synthase, putative 0.0073 0.0207 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0206 0.0206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0206 0.0206
Schistosoma mansoni trans-prenyltransferase 0.0679 0.2583 0.2583
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0049 0.048
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Echinococcus granulosus cathepsin b 0.0033 0.0049 0.0049
Echinococcus multilocularis cathepsin L cysteine protease 0.0178 0.0618 0.0618
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.0151 0.0139
Trypanosoma cruzi cysteine peptidase, putative 0.0678 0.2578 0.2568
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0079 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0119 0.0387 0.1335
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0033 0.0049 0.0019
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0033 0.0049 0.0031
Schistosoma mansoni biogenic amine receptor 0.0073 0.0206 0.0206
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi GnHR receptor homolog 0.0073 0.0206 0.0206
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0356 0.0344
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.028 0.091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0049 0.0019
Brugia malayi putative neuropeptide receptor NPR1 0.0073 0.0206 0.0206
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0033 0.0049 0.0049
Echinococcus granulosus g-protein coupled receptor 0.0073 0.0206 0.0206
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0079 0.005
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0356 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.0387 0.0359
Echinococcus granulosus somatostatin receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Plasmodium falciparum serine repeat antigen 3 0.0033 0.0049 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Brugia malayi cathepsin B-like cysteine proteinase 0.0033 0.0049 0.0049
Schistosoma mansoni myosin xvIII 0.0073 0.0206 0.0206
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0023 0.0012 0.0012
Mycobacterium tuberculosis Probable reductase 0.0111 0.0356 0.0344
Echinococcus granulosus cysteine protease 0.0092 0.028 0.028
Brugia malayi cathepsin L-like precursor 0.0119 0.0387 0.0387
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0112 0.0112
Schistosoma mansoni opsin-like receptor 0.0073 0.0206 0.0206
Onchocerca volvulus 0.0073 0.0206 0.201
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.028 0.091
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0377 0.0377
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0092 0.028 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0079 0.0067
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0033 0.0049 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0356 0.0344
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0033 0.0049 0.0031
Schistosoma mansoni cathepsin s 0.0059 0.0151 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus granulosus GPCR family 3 C terminal 0.0021 0.0003 0.0003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 0.0206 0.0206
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0151 0.0139
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0356 0.0344
Plasmodium falciparum serine repeat antigen 9 0.0033 0.0049 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0377 0.0377
Leishmania major cathepsin L-like protease 0.0178 0.0618 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.0618 0.059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1323 0.5105 0.5105
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 0.0206 0.0206
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.2572 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0075 0.0045
Trypanosoma brucei cysteine peptidase C (CPC) 0.0033 0.0049 0.0037
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 0.0206 0.0206
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0405 0.0393
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Schistosoma mansoni opsin-like receptor 0.0073 0.0206 0.0206
Schistosoma mansoni metabotropic glutamate receptor 0.0066 0.018 0.018
Plasmodium falciparum serine repeat antigen 7 0.0033 0.0049 0.0031
Brugia malayi hypothetical protein 0.0073 0.0206 0.0206
Echinococcus multilocularis neuropeptide s receptor 0.0073 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0089 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 0.0206 0.0206
Loa Loa (eye worm) polyprenyl synthetase 0.2572 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0206 0.0206
Brugia malayi Papain family cysteine protease containing protein 0.0092 0.028 0.028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0089 0.004
Brugia malayi cathepsin F-like cysteine proteinase 0.0033 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0092 0.028 0.091
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0033 0.0049 0.0031
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 0.0206 0.0206
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0178 0.0618 0.0618
Schistosoma mansoni biogenic amine receptor 0.0073 0.0206 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.0618 0.059
Loa Loa (eye worm) hypothetical protein 0.0073 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0049 0.0019
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0055 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0678 0.2578 0.2568
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0033 0.0049 0.0037
Trypanosoma cruzi polyprenyl synthase, putative 0.0742 0.2827 0.2818
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0098 0.0098
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 0.0206 0.0206
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0206 0.0206
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 0.0206 0.0206
Brugia malayi Serotonin receptor 0.0073 0.0206 0.0206
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.0637 0.0637
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0089 0.0071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.006 0.006
Brugia malayi metabotropic glutamate receptor type 2 0.005 0.0116 0.0116
Schistosoma mansoni chromobox protein 0.007 0.0196 0.0196

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 36.5 nM Effective concentration as delta agonist potency using [35S]-GTP-gammaS binding assay. ChEMBL. 11052794
EC50 (binding) = 36.5 nM Agonist potency was measured using GTP gamma-[35S] binding assay ChEMBL. 11052793
EC50 (functional) = 36.5 nM Effective concentration as delta agonist potency using [35S]-GTP-gammaS binding assay. ChEMBL. 11052794
EC50 (binding) = 36.5 nM Agonist potency was measured using GTP gamma-[35S] binding assay ChEMBL. 11052793
Emax (functional) = 104 % Maximal efficacy (Emax value) ChEMBL. 11052793
Emax (functional) = 105.5 % Emax value from 3-parameter logistic curve fits of percent stimulated [35S]-GTP-gammaS binding vs log(molar ligand). ChEMBL. 11052794
Emax (functional) = 105.5 % Emax value from 3-parameter logistic curve fits of percent stimulated [35S]-GTP-gammaS binding vs log(molar ligand). ChEMBL. 11052794
IC50 (binding) = 11.3 nM Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand. ChEMBL. 11052794
IC50 (binding) = 11.3 nM Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligand ChEMBL. 11052793
IC50 (binding) = 11.3 nM Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand. ChEMBL. 11052794
IC50 (binding) = 11.3 nM Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligand ChEMBL. 11052793
IC50 (binding) = 8150 nM Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [125I]-FK33824 as radioligand. ChEMBL. 11052794
IC50 (binding) = 8150 nM Binding affinity against cloned human Opioid receptor mu 1 using [125I]-FK33824 as radioligand ChEMBL. 11052793
IC50 (binding) = 8150 nM Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [125I]-FK33824 as radioligand. ChEMBL. 11052794
IC50 (binding) = 8150 nM Binding affinity against cloned human Opioid receptor mu 1 using [125I]-FK33824 as radioligand ChEMBL. 11052793
IC50 (binding) > 10000 nM Binding affinity on cloned opioid receptor kappa 1 in human HEK293S cells using [125I]-D-Pro10-dynorphin A[1-11] as radioligand. ChEMBL. 11052794
IC50 (binding) > 10000 nM Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligand ChEMBL. 11052793
IC50 (binding) > 10000 nM Binding affinity on cloned opioid receptor kappa 1 in human HEK293S cells using [125I]-D-Pro10-dynorphin A[1-11] as radioligand. ChEMBL. 11052794
IC50 (binding) > 10000 nM Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligand ChEMBL. 11052793
Ki (binding) nM In vitro radioligand binding assay, for inhibition of [3H]U69,593 binding to Opioid receptor kappa 1, in guinea pig brain membranes; not determined ChEMBL. 10639287
Ki (binding) 0 nM In vitro radioligand binding assay, for inhibition of [3H]U69,593 binding to Opioid receptor kappa 1, in guinea pig brain membranes; not determined ChEMBL. 10639287
Ki (binding) = 4.85 nM In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]-DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement. ChEMBL. 10639287
Ki (binding) = 4.85 nM In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]-DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement. ChEMBL. 10639287
Ki (binding) = 10000 nM In vitro radioligand binding assay, for inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membranes at highest concentration of 6800 nM tested ChEMBL. 10639287
Ki (binding) = 10000 nM In vitro radioligand binding assay, for inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membranes at highest concentration of 6800 nM tested ChEMBL. 10639287
Ki ratio (binding) > 1400 Ki ratio of mu to delta receptor ChEMBL. 10639287
Ratio (binding) = 740 Ratio of binding affinity of mu opioid receptor to that of delta opioid receptor ChEMBL. 11052793
Ratio (binding) = 741 Selectivity ratio of IC50 of mu opioid receptor to that of delta opioid receptor ChEMBL. 11052794
Ratio (binding) > 909 Selectivity ratio of IC50 of kappa opioid receptor to that of delta opioid receptor ChEMBL. 11052794
Remaining (ADMET) = 60 % Metabolic stability of the compound at a concentration of 10 microM in rat liver microsomes after 1 hr incubation ChEMBL. 11052793
Remaining (ADMET) = 89 % Metabolic stability of the compound at a concentration of 100 microM in rat liver microsomes after 1 hr incubation ChEMBL. 11052793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.