Detailed information for compound 224680

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 320.344 | Formula: C15H20N4O4
  • H donors: 4 H acceptors: 5 LogP: -0.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1cnc2c1nccc2NC1CCC1
  • InChi: 1S/C15H20N4O4/c20-6-10-12(21)13(22)15(23-10)19-7-17-11-9(4-5-16-14(11)19)18-8-2-1-3-8/h4-5,7-8,10,12-13,15,20-22H,1-3,6H2,(H,16,18)
  • InChiKey: BFAZOYNYIUQLKY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin dm0 0.0081 0.0158 0.0158
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.002 0.0149
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0354 0.0354
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0029 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0503
Onchocerca volvulus 0.0057 0.0098 0.068
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0099 0.0203 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0204 0.046 0.046
Entamoeba histolytica hypothetical protein 0.1268 0.3073 0.8004
Loa Loa (eye worm) hypothetical protein 0.0204 0.046 0.0713
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0383
Echinococcus granulosus fmrfamide receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus granulosus serotonin receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) MBCTL1 0.0055 0.0095 0.014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0034 0.0044
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0034 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.007 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Entamoeba histolytica hypothetical protein 0.0099 0.0203 0.0514
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.0098 0.0256
Echinococcus granulosus dna polymerase eta 0.0019 0.0006 0.0006
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.0098 0.0098
Echinococcus granulosus peregrin 0.0029 0.0029 0.0029
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.023 0.8837
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.0529
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0087 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Onchocerca volvulus 0.0093 0.0188 0.1535
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4088 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0216 0.0563
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0051 0.0118
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0189 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0066 0.0094
Loa Loa (eye worm) TAR-binding protein 0.0323 0.0753 0.1174
Plasmodium falciparum glutathione reductase 0.0048 0.0078 0.1337
Brugia malayi Dopamine receptor 0.0057 0.0098 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.1414 0.3432 0.8941
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0087 0.0122
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0029 0.0037
Toxoplasma gondii exonuclease III APE 0.0038 0.0051 0.067
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.1345 0.3495
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0064 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0006 0.0221
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0071
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1579 0.3838 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi RNA recognition motif domain containing protein 0.0323 0.0753 0.1962
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0006 0.0015
Schistosoma mansoni histamine h1 receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.0098 0.0098
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0203 0.2664
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0098 0.0138
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0087 0.0236
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0449 0.0449
Leishmania major trypanothione reductase 0.0048 0.0078 0.0211
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0253 0.058 0.1511
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Onchocerca volvulus 0.0057 0.0098 0.068
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.0042 0.0059
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0087 0.0226
Brugia malayi jmjC domain containing protein 0.0094 0.0189 0.0493
Trypanosoma brucei protein kinase, putative 0.0052 0.0087 0.0645
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0354 0.0354
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.4312
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.0098 0.0098
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0105 0.0216 0.0563
Loa Loa (eye worm) phosphatidylinositol 3 0.2611 0.6373 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0006 0.0008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0222 0.0505 0.6625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Loa Loa (eye worm) glutaminase 2 0.0266 0.0612 0.0952
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0034 0.0087
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Brugia malayi Dopamine receptor protein 2 0.0057 0.0098 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi PHD-finger family protein 0.0029 0.0029 0.0076
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0057 0.0057
Echinococcus multilocularis dna polymerase eta 0.0019 0.0006 0.0006
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0079 0.0114
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0098 0.0146
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0034 0.0047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) glutathione reductase 0.0048 0.0078 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Leishmania major phosphatidylinositol kinase, putative 0.0099 0.0203 0.0552
Brugia malayi G-protein coupled receptor 0.0057 0.0098 0.0256
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1102 0.2665 0.6943
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0253 0.058 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0327 0.0762 0.1984
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0142 0.0199
Echinococcus granulosus orexin receptor type 2 0.0057 0.0098 0.0098
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0564 0.1345 0.3505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Schistosoma mansoni lamin 0.0081 0.0158 0.0221
Schistosoma mansoni alpha-glucosidase 0.0139 0.0299 0.0419
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0047 0.0121
Schistosoma mansoni nuclear hormone receptor 0.003 0.0034 0.0047
Loa Loa (eye worm) hypothetical protein 0.0537 0.1279 0.1999
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi hypothetical protein 0.0025 0.002 0.0052
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0098 0.0098
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.1984
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0095 0.0095
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.073 0.1753 0.456
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0034 0.0042 0.1622
Brugia malayi nuclear hormone receptor 0.003 0.0034 0.0087
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0099 0.0203 0.0529
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0087 0.0457
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0079 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0098 0.0138
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0006 0.0221
Onchocerca volvulus 0.0057 0.0098 0.068
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0099 0.0203 0.3498
Brugia malayi MAP kinase sur-1 0.0052 0.0087 0.0226
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0243 0.0373
Entamoeba histolytica hypothetical protein 0.0099 0.0203 0.0514
Schistosoma mansoni adenoreceptor 0.0057 0.0098 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0078 0.0202
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.0098 0.0098
Loa Loa (eye worm) phosphatidylinositol 3 0.0327 0.0762 0.1187
Plasmodium falciparum thioredoxin reductase 0.0048 0.0078 0.1337
Schistosoma mansoni cpg binding protein 0.003 0.0031 0.0044
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0029 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0243 0.0373
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0041
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0098 0.0098
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0034 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0034 0.0044
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0087 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0034 0.0044
Mycobacterium tuberculosis Probable reductase 0.011 0.023 0.8837
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0327 0.0762 0.1972
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0078 0.0113
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0047 0.0047
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.0098 0.0146
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0327 0.0762 0.2072
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1579 0.3838 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0055 0.0055
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0034 0.0034
Echinococcus multilocularis geminin 0.0671 0.1607 0.1607
Brugia malayi Serotonin receptor 0.0057 0.0098 0.0256
Echinococcus granulosus g protein coupled receptor 0.0057 0.0098 0.0098
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0098 0.0138
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Schistosoma mansoni fkbp-rapamycin associated protein 0.0204 0.046 0.0644
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Onchocerca volvulus 0.0057 0.0098 0.068
Brugia malayi neuropeptide F receptor 0.0057 0.0098 0.0256
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0346
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0098 0.0138
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0204 0.046 0.1198
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0094
Echinococcus granulosus g protein coupled receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.002 0.0264
Onchocerca volvulus 0.0057 0.0098 0.068
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0064 0.0092
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi mbt repeat family protein 0.0049 0.0079 0.0205
Loa Loa (eye worm) hypothetical protein 0.0222 0.0505 0.0783
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Schistosoma mansoni biogenic amine receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.007 0.0182
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Leishmania major DNA polymerase eta, putative 0.0019 0.0006 0.0016
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0094
Onchocerca volvulus 0.0057 0.0098 0.068
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.026 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0034 0.0042 0.0688
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.0098 0.0098
Brugia malayi Melatonin receptor type 1A 0.0057 0.0098 0.0256
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.0098 0.068
Brugia malayi MH2 domain containing protein 0.0116 0.0243 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0123 0.0261 0.0261
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0564 0.1345 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0206 0.0466 0.0466
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.0098 0.0098
Echinococcus granulosus neuropeptide s receptor 0.0057 0.0098 0.0098
Brugia malayi larval opioid receptor 0.0057 0.0098 0.0256
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0034 0.0042 0.0115
Schistosoma mansoni glutaminase 0.0266 0.0612 0.0858
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Onchocerca volvulus 0.0057 0.0098 0.068
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.2072
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0564 0.1345 0.1884
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0034 0.0047
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0034 0.0058
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0047 0.0047
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0098 0.0098
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.148 0.3594 0.9363
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0158 0.0412
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Loa Loa (eye worm) hypothetical protein 0.0105 0.0216 0.033
Echinococcus granulosus cpg binding protein 0.003 0.0031 0.0031
Onchocerca volvulus 0.0057 0.0098 0.068
Echinococcus granulosus dna polymerase kappa 0.0019 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0327 0.0762 0.0762
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.088
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0327 0.0762 0.0762
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0327 0.0762 0.1067
Echinococcus multilocularis cpg binding protein 0.003 0.0031 0.0031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0034 0.0034
Echinococcus granulosus dnaJ subfamily B 0.0398 0.0936 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2923 0.7138 1
Echinococcus granulosus allatostatin A receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis serotonin receptor 0.0057 0.0098 0.0098
Schistosoma mansoni cpg binding protein 0.003 0.0031 0.0044
Schistosoma mansoni hypothetical protein 0.0099 0.0203 0.0284
Brugia malayi steroid hormone receptor 0.003 0.0034 0.0087
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0006 0.0043
Loa Loa (eye worm) phosphatidylinositol kinase 0.0099 0.0203 0.031
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Loa Loa (eye worm) phosphatidylinositol 3 0.0327 0.0762 0.1187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni intermediate filament proteins 0.0081 0.0158 0.0221
Brugia malayi Serotonin receptor 0.0057 0.0098 0.0256
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0346
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.088
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0354 0.0547
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0099 0.0203 0.0529
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0203 0.2664
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.0133
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0216 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi AKH receptor 0.0057 0.0098 0.0256
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0034 0.0034
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.023 0.8837
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0327 0.0762 0.1067
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0047 0.0064
Entamoeba histolytica hypothetical protein 0.0099 0.0203 0.0514
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.0098 0.068
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0051 0.1964
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0203 0.3498
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0123 0.0261 0.0261
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.0098 0.0138
Onchocerca volvulus 0.0099 0.0203 0.1681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0034 0.0044
Echinococcus multilocularis tar DNA binding protein 0.0323 0.0753 0.0753
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0087 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trypanosoma cruzi target of rapamycin kinase 3 0.0327 0.0762 0.1984
Brugia malayi sulfakinin receptor protein 0.0057 0.0098 0.0256
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0099 0.0203 0.1508
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1042 0.2518 0.2518
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0327 0.0762 0.2072
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.1345 0.3495
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0047 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Loa Loa (eye worm) hypothetical protein 0.0039 0.0055 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1268 0.3073 0.8004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0253 0.058 0.1511
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0034 0.0087
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.1578
Onchocerca volvulus 0.0049 0.0079 0.049
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.0098 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0047 0.0121
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.026 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.0098 0.0256
Echinococcus multilocularis microtubule associated protein 2 0.1392 0.3379 0.3379
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Echinococcus multilocularis Protein lozenge 0.0057 0.0098 0.0098
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0253 0.058 0.1498
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0104 0.0154
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0533 0.0533
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0047 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.0025 0.002 0.0055
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.0098 0.0256
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.007 0.0098
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0034 0.0034
Echinococcus multilocularis lamin 0.0081 0.0158 0.0158
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.0098 0.0098
Onchocerca volvulus 0.0057 0.0098 0.068
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Brugia malayi hypothetical protein 0.0234 0.0533 0.1388
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.3498
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0034 0.0087
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.0098 0.0138
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1579 0.3838 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0114
Onchocerca volvulus 0.0057 0.0098 0.068
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0204 0.046 0.3419
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0079 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0261 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0034 0.0087
Onchocerca volvulus 0.0099 0.0203 0.1681
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0079 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Schistosoma mansoni alpha-glucosidase 0.0139 0.0299 0.0419
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0104 0.0146
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0253 0.058 0.0902
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1579 0.3838 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0089 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0006 0.0008
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0 0.5
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0133
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.0098 0.0098
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.0098 0.0098
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0099 0.0203 0.0529
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0034 0.0047
Loa Loa (eye worm) hypothetical protein 0.0453 0.1071 0.1672
Echinococcus granulosus jumonji domain containing protein 0.004 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.0098 0.0098
Brugia malayi glutaminase DH11.1 0.0266 0.0612 0.1595
Schistosoma mansoni thyroid hormone receptor 0.003 0.0034 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0034 0.0044
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0006
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0079 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0327 0.0762 0.5662
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Leishmania major hypothetical protein, unknown function 0.0099 0.0203 0.0552
Echinococcus granulosus lamin 0.0081 0.0158 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0465 0.1101 0.2869
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0564 0.1345 0.3505
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0098 0.0098
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.0379
Onchocerca volvulus 0.0453 0.1071 1
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0051 0.0133
Trichomonas vaginalis glutaminase, putative 0.0266 0.0612 0.1595
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.0098 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0034 0.0047
Giardia lamblia PHD finger protein 15 0.0029 0.0029 0.0154
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0051 0.0051
Leishmania major DNA polymerase kappa, putative 0.0019 0.0006 0.0016
Schistosoma mansoni survival motor neuron protein 0.0048 0.0076 0.0106
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.007 0.0101
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1042 0.2518 0.6561
Brugia malayi G-protein coupled receptor 0.0057 0.0098 0.0256
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0099 0.0203 0.1508
Leishmania major phosphatidylinositol kinase related protein, putative 0.0099 0.0203 0.0552
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0098 0.0098
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0051 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0098 0.0138
Brugia malayi ORL1-like opioid receptor 0.0057 0.0098 0.0256
Echinococcus multilocularis lamin dm0 0.0081 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0034 0.0087
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0047 0.0121
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0123 0.0261 0.04
Echinococcus multilocularis allatostatin A receptor 0.0057 0.0098 0.0098
Brugia malayi follicle stimulating hormone receptor 0.0057 0.0098 0.0256
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1579 0.3838 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0052
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0034 0.0058
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Schistosoma mansoni biogenic amine receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0204 0.046 0.1198
Echinococcus granulosus hypothetical protein 0.0057 0.0098 0.0098
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0099 0.0203 0.0514
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1343 0.3259 0.849
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0078 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Echinococcus multilocularis peregrin 0.0029 0.0029 0.0029
Leishmania major phosphatidylinositol 3-kinase, putative 0.0253 0.058 0.1578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0051 0.0071
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.026 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0253 0.058 0.1498
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0383
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0051 0.0051
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.0098 0.0098
Echinococcus multilocularis serine protein kinase ATM 0.0204 0.046 0.046
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0099 0.0203 0.0529
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1042 0.2518 0.2518
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.0098 0.0098
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0076 0.0198
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.0098 0.0098
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0327 0.0762 0.0762
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Loa Loa (eye worm) hypothetical protein 0.0453 0.1071 0.1672
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0087 0.1139
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0411 0.0968 0.5095
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0253 0.058 0.0813
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.0098 0.0098
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0203 0.7809
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Loa Loa (eye worm) glutaminase 0.0266 0.0612 0.0952
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0051 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi mbt repeat family protein 0.0049 0.0079 0.0205
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) RNA binding protein 0.0323 0.0753 0.1174
Onchocerca volvulus Alhambra homolog 0.0029 0.0029 0.0016
Onchocerca volvulus 0.0057 0.0098 0.068
Schistosoma mansoni hypothetical protein 0.0398 0.0936 0.1312
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0095 0.0133
Schistosoma mansoni opsin-like receptor 0.0057 0.0098 0.0138
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0354 0.0923
Echinococcus granulosus sex peptide receptor 0.0057 0.0098 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0203 0.2664
Leishmania major phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.0552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.007 0.0098
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.0936 0.0936
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.0098 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0034 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0034 0.0087
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.0098 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.0042 0.0059
Toxoplasma gondii aldehyde dehydrogenase 0.0034 0.0042 0.0553
Echinococcus multilocularis orexin receptor type 2 0.0057 0.0098 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0034 0.0087
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2923 0.7138 0.7138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Schistosoma mansoni coup transcription factor 0.003 0.0034 0.0047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0034 0.0034
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.3498
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni cpg binding protein 0.0028 0.0027 0.0039
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0564 0.1345 0.3505
Loa Loa (eye worm) hypothetical protein 0.0234 0.0533 0.0828
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Schistosoma mansoni hypothetical protein 0.0304 0.0705 0.0988
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0253 0.058 0.7616
Onchocerca volvulus 0.0057 0.0098 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.0098 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Echinococcus granulosus FTZ F1 alpha 0.003 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0538 0.1282 0.2004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0204 0.046 0.1198
Onchocerca volvulus 0.003 0.0034 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0087 0.0226
Plasmodium vivax hypothetical protein 0.0099 0.0203 0.3498
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0006 0.0016
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0099 0.0203 0.0284
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0057 0.0149
Loa Loa (eye worm) phosphatidylinositol 3 0.0465 0.1101 0.172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0034 0.0047
Schistosoma mansoni lamin 0.0081 0.0158 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0034 0.0044
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1102 0.2665 0.6943
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0034 0.0047
Echinococcus granulosus serine protein kinase ATM 0.0204 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0055 0.0095 0.014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0051 0.0833
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0098 0.0138
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0044 0.0062
Echinococcus granulosus intermediate filament protein 0.0081 0.0158 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0203 0.0529
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0095 0.0248
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Brugia malayi FAT domain containing protein 0.0123 0.0261 0.0679
Brugia malayi TAR-binding protein 0.0323 0.0753 0.1962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0044 0.0044
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0253 0.058 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Onchocerca volvulus 0.0057 0.0098 0.068
Plasmodium vivax glutathione reductase, putative 0.0048 0.0078 0.1337
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.5662
Brugia malayi hypothetical protein 0.0035 0.0044 0.0116
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0533 0.0533
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0047 0.0121
Brugia malayi GnHR receptor homolog 0.0057 0.0098 0.0256
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus g-protein coupled receptor 0.0057 0.0098 0.0098
Echinococcus granulosus neuropeptide receptor 0.0057 0.0098 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.007 0.0098
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0095 0.0095
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.0098 0.0098
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0029 0.0029
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.0098 0.0146
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0047 0.0127
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0015
Echinococcus granulosus tar DNA binding protein 0.0323 0.0753 0.0753
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0078 0.1337
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.0529
Loa Loa (eye worm) hypothetical protein 0.0081 0.0158 0.0239
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0079 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0098 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0099 0.0203 0.0529
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0203 0.0529
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0204 0.046 0.1198
Onchocerca volvulus 0.0081 0.0158 0.1251
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0006 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0034 0.0087
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.1984
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0095 0.0095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.023 0.8837
Loa Loa (eye worm) hypothetical protein 0.0038 0.0051 0.0072
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0034 0.0034
Loa Loa (eye worm) runx1 0.0057 0.0098 0.0145
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0034 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0051 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0048 0.0066
Brugia malayi G protein-coupled receptor 0.0057 0.0098 0.0256
Entamoeba histolytica protein kinase rad3, putative 0.0204 0.046 0.1185
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0047 0.0107
Echinococcus multilocularis 0.0099 0.0203 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0386 0.1005
Echinococcus granulosus geminin 0.0671 0.1607 0.1607
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0034 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.1042 0.2518 0.3946
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.0576 0.1501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0087 0.0236
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni biogenic amine receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0253 0.058 0.1511
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0253 0.058 0.1511
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0671 0.1607 0.2251
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0386 0.1005
Schistosoma mansoni hypothetical protein 0.0671 0.1607 0.2251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Schistosoma mansoni alpha glucosidase 0.0036 0.0047 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0327 0.0762 0.5662
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Brugia malayi ecdysteroid receptor 0.003 0.0034 0.0087
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0034 0.0087
Toxoplasma gondii target of rapamycin (TOR), putative 0.0327 0.0762 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.1508
Echinococcus multilocularis musashi 0.0081 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0035 0.0044 0.0062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1579 0.3838 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.0078 0.1018
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.0098 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Leishmania major phosphatidylinositol 3-kinase, putative 0.0327 0.0762 0.2072
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Brugia malayi Dopamine receptor protein 1 0.0538 0.1282 0.3339
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.0098 0.0256
Giardia lamblia GTOR 0.0327 0.0762 0.4009
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0034 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.007 0.007
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0047 0.0612
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.002 0.0346
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0253 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0449 0.0449
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.023 0.8837
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0203 0.0529
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0327 0.0762 0.5662
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0064 0.0064
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.0098 0.0138
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.079 0.19 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0048 0.0067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0564 0.1345 0.3505
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0034 0.0087
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0057 0.0149
Brugia malayi putative neuropeptide receptor 0.0057 0.0098 0.0256
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0074 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.023 0.4693
Schistosoma mansoni lozenge 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni hypothetical protein 0.0048 0.0076 0.0106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0078 0.2985
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0038 0.0051 0.0072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0034 0.0034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0034 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0203 0.0529
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0087 0.0087
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.0098 0.0146
Echinococcus granulosus somatostatin receptor 0.0057 0.0098 0.0098
Trypanosoma brucei unspecified product 0.0019 0.0006 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0327 0.0762 0.1984
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0203 0.0529
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0034 0.0087
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.0098 0.0098
Brugia malayi hypothetical protein 0.0453 0.1071 0.2789
Trypanosoma brucei glucosidase, putative 0.0036 0.0047 0.0347
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0098 0.0098
Brugia malayi Bromodomain containing protein 0.0029 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus multilocularis serotonin receptor 0.0057 0.0098 0.0098
Brugia malayi glutathione reductase 0.0048 0.0078 0.0202
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0098 0.0146
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0023
Mycobacterium ulcerans glutaminase 0.0266 0.0612 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0079 0.049
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni thyroid hormone receptor 0.003 0.0034 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0034 0.0042 0.0688
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.0098 0.0098
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0034 0.0087
Plasmodium falciparum phd finger protein, putative 0.0029 0.0029 0.0503
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0055 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0564 0.1345 0.3505
Schistosoma mansoni opsin-like receptor 0.0057 0.0098 0.0138
Brugia malayi neuropeptide F receptor 0.0057 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0099 0.0203 0.0203
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0327 0.0762 0.1984
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0099 0.0203 0.3498
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0364 0.3224
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0327 0.0762 0.5662
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0079 0.0079
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0066 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0087 0.0645
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0158 0.0239
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0034 0.0042 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0057 0.0098 0.0146
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0034 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Onchocerca volvulus 0.0057 0.0098 0.068
Onchocerca volvulus 0.0057 0.0098 0.068
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0133
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0074 0.0104
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0253 0.058 0.058
Entamoeba histolytica hypothetical protein 0.0204 0.046 0.1185
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0044 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Brugia malayi Thioredoxin reductase 0.0048 0.0078 0.0202
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0078 0.0078
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0253 0.058 0.7616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.163 0.3962 0.3962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.007 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0037 0.005 0.007
Brugia malayi nuclear receptor NHR-88 0.003 0.0034 0.0087
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0095 0.0095
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0204 0.046 0.1185
Brugia malayi jmjC domain containing protein 0.0036 0.0048 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0204 0.046 0.046
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0327 0.0762 0.1984
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0204 0.046 0.0644
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0034 0.0042 0.0688
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0099 0.0203 0.0284
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0327 0.0762 0.2072
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Giardia lamblia DINP protein human, muc B family 0.0019 0.0006 0.003
Schistosoma mansoni myosin xvIII 0.0057 0.0098 0.0138
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0006 0.0008
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.0098 0.0098
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0051 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0034 0.0044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0034 0.0047
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0098 0.0146
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0034 0.0047
Echinococcus granulosus g protein coupled receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0027 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Brugia malayi CXXC zinc finger family protein 0.0028 0.0027 0.0072
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0253 0.058 0.058
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Onchocerca volvulus 0.0048 0.0076 0.0464
Giardia lamblia Phosphatidylinositol 4-kinase 0.0099 0.0203 0.1068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0203 0.0529
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0048 0.0067
Echinococcus multilocularis somatostatin receptor 0.0057 0.0098 0.0098
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.0098 0.0098
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis sex peptide receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0222 0.0505 0.1314
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.023 0.8837
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0158 0.0239
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.1511
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0327 0.0762 0.0762
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.0098 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0034 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.0505 0.1314
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0116
Loa Loa (eye worm) hypothetical protein 0.0099 0.0203 0.031
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0079 0.011
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.1511
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0099 0.0203 0.3498
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.2923 0.7138 0.7138
Echinococcus granulosus neuropeptide receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.0098 0.0146
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0051 1
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0098 0.0098
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.0098 0.0138
Toxoplasma gondii FATC domain-containing protein 0.0204 0.046 0.6039
Schistosoma mansoni microtubule-associated protein tau 0.1392 0.3379 0.4733
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.026 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0052
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.0576 0.0896
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Schistosoma mansoni opsin-like receptor 0.0057 0.0098 0.0138
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0098 0.0098
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0327 0.0762 0.1972
Brugia malayi intermediate filament protein 0.0081 0.0158 0.0412
Leishmania major hypothetical protein, conserved 0.1513 0.3676 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0222 0.0505 0.3751
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.0098 0.0256
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0253 0.058 0.0813
Onchocerca volvulus 0.0081 0.0158 0.1251
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0047 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0034 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0003 0.0007
Onchocerca volvulus 0.0057 0.0098 0.068
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Onchocerca volvulus 0.0057 0.0098 0.068
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0037
Trypanosoma brucei trypanothione reductase 0.0048 0.0078 0.0577
Echinococcus granulosus microtubule associated protein 2 0.1392 0.3379 0.3379
Schistosoma mansoni hypothetical protein 0.0123 0.0261 0.0365
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0047 0.0121
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0034 0.0058
Brugia malayi RE15519p 0.0057 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.008 0.0154 0.0233
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1579 0.3838 1
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0034 0.0034
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0087 0.0127
Giardia lamblia Hypothetical protein 0.0099 0.0203 0.1068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Brugia malayi RNA binding protein 0.0323 0.0753 0.1962
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Echinococcus multilocularis Zinc finger, PHD finger 0.0253 0.058 0.058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0323 0.0753 0.1174
Echinococcus granulosus tm gpcr rhodopsin 0.0206 0.0466 0.0466
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0006 0.0015

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 100 uM In vitro evaluation of anti-HIV-1 activity in C8166 cells infected with HIV-1 IIIB. ChEMBL. 7562937
Ki (binding) = 100 uM Inhibition calf intestine adenosine deaminase ChEMBL. 7562937
TC50 (ADMET) > 100 uM In vitro evaluation of cytotoxicity in C8166 cells infected with HIV-1 IIIB. ChEMBL. 7562937

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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