TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 644.76 | Formula: C35H44N6O6
H donors: 3 H acceptors: 7 LogP: 3.63 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)c1nccnc1)OCc1cccc2c1cccc2)C=O
InChi: 1S/C35H44N6O6/c1-6-25(19-42)38-33(44)29-16-26(47-20-24-12-9-11-23-10-7-8-13-27(23)24)18-41(29)35(46)31(22(4)5)40-34(45)30(21(2)3)39-32(43)28-17-36-14-15-37-28/h7-15,17,19,21-22,25-26,29-31H,6,16,18,20H2,1-5H3,(H,38,44)(H,39,43)(H,40,45)/t25-,26+,29-,30+,31+/m0/s1
InChiKey: KUZWHLFHAWVQGA-UWPYJHSNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus serine protease, NS3/NS4A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	hypothetical protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	50 aa	28.0 %
Entamoeba histolytica	hypothetical protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	52 aa	23.1 %
Trypanosoma brucei	expression site-associated gene 3 (ESAG3)-like protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	49 aa	28.6 %
Trypanosoma brucei	hypothetical protein, conserved	Hepatitis C virus serine protease, NS3/NS4A	54 aa	55 aa	30.9 %
Schistosoma japonicum	expressed protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	44 aa	29.5 %
Leishmania braziliensis	hypothetical protein, conserved	Hepatitis C virus serine protease, NS3/NS4A	54 aa	46 aa	26.1 %
Mycobacterium ulcerans	Maf-like protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	44 aa	38.6 %
Schistosoma mansoni	hypothetical protein	Hepatitis C virus serine protease, NS3/NS4A	54 aa	44 aa	29.5 %
Echinococcus granulosus	60S ribosomal protein L8	Hepatitis C virus serine protease, NS3/NS4A	54 aa	48 aa	33.3 %
Trypanosoma brucei gambiense	expression site-associated gene 3 (ESAG3)-like protein, putative	Hepatitis C virus serine protease, NS3/NS4A	54 aa	49 aa	28.6 %
Mycobacterium tuberculosis	Membrane-associated phospholipase C 2 PlcB	Hepatitis C virus serine protease, NS3/NS4A	54 aa	49 aa	32.7 %
Trypanosoma congolense	WD40 repeats, putative	Hepatitis C virus serine protease, NS3/NS4A	54 aa	46 aa	28.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0034	0.036	0.036
Brugia malayi	Glutamate receptor 1 precursor	0.0011	0.0013	0.0017
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0064	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1031	0.1414
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0064	0.0067
Brugia malayi	A-kinase anchor protein 10, precursor	0.0011	0.0003	0.0004
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0034	0.036	0.0381
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0064	0.0801	0.0848
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.1419
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0159	0.0168
Plasmodium falciparum	glutathione reductase	0.0022	0.0172	0.0677
Loa Loa (eye worm)	hypothetical protein	0.005	0.0591	0.081
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0034	0.036	0.036
Brugia malayi	PXA domain containing protein	0.0011	0.0003	0.0004
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0012	0.0019	0.002
Echinococcus granulosus	axis inhibition protein axin	0.0011	0.0003	0.0003
Echinococcus granulosus	ecdysone induced protein 78C	0.0031	0.0312	0.033
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0064	0.0801	0.0848
Echinococcus multilocularis	axis inhibition protein axin	0.0011	0.0003	0.0003
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0103	0.1399	0.269
Echinococcus multilocularis	glutamate receptor 2	0.0013	0.0045	0.0048
Echinococcus granulosus	neuropeptide receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	esterase, putative	0.005	0.0591	0.1534
Loa Loa (eye worm)	steroid hormone receptor	0.0031	0.0312	0.0428
Echinococcus multilocularis	importin subunit beta 1	0.0012	0.0027	0.0029
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0283	0.4102	0.4341
Giardia lamblia	PHD finger protein 15	0.0033	0.0332	0.0766
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0013	0.0031	0.0031
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Schistosoma mansoni	caspase-7 (C14 family)	0.0034	0.0361	0.0382
Echinococcus multilocularis	beta LACTamase domain containing family member	0.005	0.0591	0.0625
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0015	0.0064	0.0067
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0015	0.0067	0.0071
Schistosoma mansoni	phosphoglycerate kinase	0.0103	0.1399	0.1481
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0034	0.036	0.036
Brugia malayi	Cell death protein 3 precursor	0.0034	0.0361	0.0496
Schistosoma mansoni	ap endonuclease	0.0026	0.0229	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0006	0.0007
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0312	0.0428
Echinococcus granulosus	7tm_1 domain containing protein	0.0064	0.0801	0.0848
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.004	0.0096
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.3352	0.4598
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Plasmodium falciparum	glutathione reductase	0.0063	0.0794	0.313
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0446	0.0472
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Leishmania major	DNA polymerase eta, putative	0.0036	0.0392	0.0392
Schistosoma mansoni	amine GPCR	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0527	0.0723
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0064	0.0801	0.0848
Brugia malayi	Pre-SET motif family protein	0.0233	0.3352	0.4598
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.036	0.036
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0129	0.0136
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0064	0.0801	0.0848
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0641	0.0678
Loa Loa (eye worm)	glutathione reductase	0.0063	0.0794	0.109
Schistosoma mansoni	regulator of G protein signaling	0.0011	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0312	0.0428
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	Glutamate receptor 2 precursor	0.0011	0.0013	0.0017
Schistosoma mansoni	amine GPCR	0.0064	0.0801	0.0848
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0012	0.0019	0.002
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0034	0.036	0.0381
Onchocerca volvulus		0.0169	0.2383	0.3209
Echinococcus granulosus	g-protein coupled receptor	0.0064	0.0801	0.0848
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0064	0.0801	0.1099
Mycobacterium tuberculosis	Conserved protein	0.005	0.0591	0.1131
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0312	0.0428
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0031	0.0312	0.0428
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0015	0.0064	0.0067
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0179	0.2538	0.3481
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0283	0.4102	0.4341
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus multilocularis	chromobox protein 1	0.0037	0.0398	0.0421
Schistosoma mansoni	opsin-like receptor	0.0064	0.0801	0.0848
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Brugia malayi	nuclear hormone receptor family member odr-7	0.0015	0.0064	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0031	0.0312	0.0428
Schistosoma mansoni	glutamate receptor AMPA	0.0011	0.0013	0.0013
Echinococcus granulosus	fmrfamide receptor	0.0064	0.0801	0.0848
Brugia malayi	sulfakinin receptor protein	0.0064	0.0801	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0103	0.1399	0.1399
Schistosoma mansoni	glutamate receptor NMDA	0.0013	0.0045	0.0048
Brugia malayi	larval opioid receptor	0.0064	0.0801	0.1099
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0283	0.4102	0.4341
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0179	0.2538	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0022	0.0172	0.0172
Plasmodium falciparum	importin beta, putative	0.0012	0.0027	0.0106
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.004	0.0096
Echinococcus granulosus	g protein coupled receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	D-aminoacylase, putative	0.005	0.0591	0.1534
Schistosoma mansoni	amine GPCR	0.0064	0.0801	0.0848
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0103	0.1399	0.1399
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0026	0.0229	0.0903
Brugia malayi	Serotonin receptor	0.0064	0.0801	0.1099
Trypanosoma cruzi	PAB1-binding protein , putative	0.002	0.0142	0.0142
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0026	0.0229	0.0229
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0064	0.0801	0.1099
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.023	0.3314	0.3508
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0487	0.0668
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0034	0.036	0.0381
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0022	0.0172	0.0677
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0674	1	1
Onchocerca volvulus		0.0064	0.0801	0.1021
Leishmania major	hypothetical protein, conserved	0.0017	0.0099	0.0099
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0064	0.0801	0.0848
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0012	0.0019	0.0043
Schistosoma mansoni	hypothetical protein	0.0131	0.1819	0.1925
Brugia malayi	conserved hypotetical protein	0.0015	0.0064	0.0087
Echinococcus granulosus	thioredoxin glutathione reductase	0.0063	0.0794	0.0841
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	GnHR receptor homolog	0.0064	0.0801	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.004	0.0096
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.1771	0.2429
Brugia malayi	jmjC domain containing protein	0.0043	0.0494	0.0678
Loa Loa (eye worm)	T-complex protein 1	0.0012	0.0019	0.0027
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0801	0.0848
Brugia malayi	PXA domain containing protein	0.0011	0.0003	0.0004
Brugia malayi	steroid hormone receptor	0.0031	0.0312	0.0428
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.0591	0.0591
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	Pre-SET motif family protein	0.0034	0.0354	0.0486
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0159	0.0299
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0013	0.0031	0.0121
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0022	0.0172	0.0677
Trypanosoma cruzi	trypanothione reductase, putative	0.0022	0.0172	0.0172
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0795	0.1937
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.0524	0.0555
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0103	0.1399	0.1481
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.005	0.0591	0.0625
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0072	0.0077
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0159	0.0615
Brugia malayi	regulator of G-protein signaling egl-10	0.0011	0.0003	0.0004
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0159	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0103	0.1399	0.3643
Mycobacterium ulcerans	lipase LipD	0.005	0.0591	0.1131
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0013	0.0045	0.0048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0123	0.1703	0.1803
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.009	0.0095
Echinococcus granulosus	FTZ F1 alpha	0.0031	0.0312	0.033
Trypanosoma brucei	phosphoglycerate kinase	0.0103	0.1399	0.1399
Echinococcus multilocularis	neuropeptides capa receptor	0.0064	0.0801	0.0848
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	hypothetical protein	0.0064	0.0801	0.0848
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0159	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus multilocularis	serotonin receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0494	0.7291	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0011	0.0003	0.0003
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0283	0.4102	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.005	0.0591	0.1534
Trichomonas vaginalis	glutathione reductase, putative	0.0022	0.0172	0.0441
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Loa Loa (eye worm)	runx1	0.0062	0.0776	0.1065
Echinococcus multilocularis	orexin receptor type 2	0.0064	0.0801	0.0848
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0031	0.0312	0.033
Schistosoma mansoni	hypothetical protein	0.0015	0.0072	0.0077
Loa Loa (eye worm)	neuropeptide F receptor	0.0064	0.0801	0.1099
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0319	0.4649	0.4649
Plasmodium falciparum	phosphodiesterase delta, putative	0.0034	0.036	0.1419
Brugia malayi	Importin beta-1 subunit	0.0012	0.0027	0.0037
Echinococcus multilocularis	chromobox protein 1	0.0037	0.0398	0.0421
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Echinococcus granulosus	regulator of G protein signaling 3	0.0011	0.0003	0.0003
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0159	0.0159
Schistosoma mansoni	flap endonuclease-1	0.0011	0.0013	0.0014
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.009	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Echinococcus multilocularis	sex peptide receptor	0.0064	0.0801	0.0848
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0013	0.0031	0.0031
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0064	0.0801	0.0848
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0494	0.0523
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0332	0.0351
Entamoeba histolytica	Flap nuclease, putative	0.0013	0.0031	0.0113
Trichomonas vaginalis	D-aminoacylase, putative	0.005	0.0591	0.1534
Echinococcus multilocularis	regulator of G protein signaling	0.0011	0.0003	0.0003
Brugia malayi	Steroid receptor seven-up type 2	0.0031	0.0312	0.0428
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0159	0.0299
Trypanosoma brucei	phosphoglycerate kinase	0.0103	0.1399	0.1399
Echinococcus granulosus	neuropeptide Y receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.004	0.0096
Schistosoma mansoni	ap endonuclease	0.0026	0.0229	0.0243
Loa Loa (eye worm)	melatonin receptor type 1A	0.0064	0.0801	0.1099
Schistosoma mansoni	hypothetical protein	0.0033	0.034	0.036
Plasmodium vivax	glutathione reductase, putative	0.0063	0.0794	0.313
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0103	0.1399	0.1481
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0013	0.0045	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.036	0.0494
Trichomonas vaginalis	ap endonuclease, putative	0.0026	0.0229	0.059
Echinococcus granulosus	biogenic amine 5HT receptor	0.0064	0.0801	0.0848
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0064	0.0087
Trypanosoma brucei	phosphoglycerate kinase	0.0038	0.0413	0.0413
Plasmodium falciparum	phd finger protein, putative	0.0033	0.0332	0.1308
Echinococcus granulosus	flap endonuclease 1	0.0013	0.0031	0.0033
Schistosoma mansoni	regulator of G protein signaling	0.0011	0.0003	0.0003
Schistosoma mansoni	nuclear receptor	0.0015	0.0064	0.0067
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0034	0.0361	0.0383
Echinococcus multilocularis	axis inhibition protein axin	0.0011	0.0003	0.0003
Schistosoma mansoni	chromobox protein	0.0037	0.0398	0.0421
Schistosoma mansoni	amine GPCR	0.0064	0.0801	0.0848
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0064	0.0801	0.1099
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0312	0.033
Brugia malayi	Thioredoxin reductase	0.0063	0.0794	0.109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0006	0.0009
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0034	0.036	0.0381
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0095	0.127	0.127
Brugia malayi	nuclear receptor NHR-67	0.0015	0.0064	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	hypothetical protein	0.0016	0.009	0.0124
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0159	0.0168
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0103	0.1399	0.192
Schistosoma mansoni	histamine h1 receptor	0.0064	0.0801	0.0848
Brugia malayi	Bm-MIF-1, identical	0.0179	0.2538	0.3481
Brugia malayi	hypothetical protein	0.0034	0.0361	0.0496
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0031	0.0312	0.033
Echinococcus granulosus	snurportin 1	0.0131	0.1819	0.1925
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.006	0.006
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Mycobacterium tuberculosis	Probable lipase LipE	0.005	0.0591	0.1131
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0031	0.0312	0.0428
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.0124
Echinococcus granulosus	regulator of G protein signaling 3	0.0011	0.0003	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0031	0.0312	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0641	0.0879
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.036	0.0932
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0103	0.1399	0.5508
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0013	0.0031	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	hypothetical protein	0.0064	0.0801	0.0848
Mycobacterium tuberculosis	Conserved protein	0.005	0.0591	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0197	0.281	0.3854
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.036	0.036
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0007	0.0007
Echinococcus multilocularis	neuropeptides capa receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	nuclear receptor nhr-48	0.0015	0.0064	0.0067
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus multilocularis	neuropeptide receptor A26	0.0064	0.0801	0.0848
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0022	0.0172	0.0172
Loa Loa (eye worm)	thioredoxin reductase	0.0063	0.0794	0.109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma brucei	DNA polymerase eta, putative	0.0036	0.0392	0.0392
Mycobacterium tuberculosis	Probable hydrolase	0.005	0.0591	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Schistosoma mansoni	coup transcription factor	0.0031	0.0312	0.033
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0022	0.0172	0.0374
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Schistosoma mansoni	hypothetical protein	0.0017	0.0099	0.0105
Onchocerca volvulus		0.0064	0.0801	0.1021
Leishmania major	hypothetical protein, conserved	0.005	0.0591	0.0591
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0123	0.1703	0.1803
Loa Loa (eye worm)	neuropeptide F receptor	0.0064	0.0801	0.1099
Echinococcus granulosus	serotonin receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Onchocerca volvulus		0.005	0.0591	0.0729
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Schistosoma mansoni	glutamate receptor kainate	0.0011	0.0013	0.0013
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0072	0.0077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Echinococcus multilocularis	FTZ F1 alpha	0.0031	0.0312	0.033
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0034	0.036	0.0381
Brugia malayi	T-complex protein 1, beta subunit	0.0012	0.0019	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0061	0.0084
Echinococcus granulosus	neuropeptide s receptor	0.0064	0.0801	0.0848
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0064	0.0801	0.0848
Schistosoma mansoni	hypothetical protein	0.0011	0.0002	0.0002
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0064	0.0801	0.0848
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Echinococcus multilocularis	regulator of G protein signaling 3	0.0011	0.0003	0.0003
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0034	0.036	0.036
Onchocerca volvulus		0.0064	0.0801	0.1021
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0586	0.0804
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0064	0.0801	0.0848
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0332	0.0351
Trichomonas vaginalis	chaperonin, putative	0.0012	0.0019	0.0043
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus multilocularis	neuropeptide Y receptor	0.0064	0.0801	0.0848
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Trypanosoma brucei	PAB1-binding protein , putative	0.002	0.0142	0.0142
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0034	0.036	0.0494
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0064	0.0801	0.1021
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0011	0.0007	0.0009
Schistosoma mansoni	cpg binding protein	0.0035	0.0373	0.0395
Schistosoma mansoni	chromobox protein	0.0037	0.0398	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0064	0.0801	0.0848
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Echinococcus multilocularis	nuclear receptor nhr 48	0.0015	0.0064	0.0067
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0026	0.0229	0.0229
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0011	0.0003	0.0003
Trypanosoma brucei	importin beta-1 subunit, putative	0.0012	0.0027	0.0027
Schistosoma mansoni	cpg binding protein	0.0031	0.0314	0.0332
Brugia malayi	hypothetical protein	0.0011	0.0003	0.0004
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0022	0.0172	0.0172
Echinococcus granulosus	importin subunit beta 1	0.0012	0.0027	0.0029
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0031	0.0312	0.033
Schistosoma mansoni	hypothetical protein	0.0015	0.0072	0.0077
Echinococcus multilocularis	caspase 2	0.0034	0.0361	0.0382
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0319	0.4649	0.4649
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0398	0.1031
Brugia malayi	PHD-finger family protein	0.0015	0.0061	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0031	0.0312	0.033
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0674	1	1
Schistosoma mansoni	opsin-like receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0034	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0332	0.0455
Loa Loa (eye worm)	beta-lactamase	0.005	0.0591	0.081
Echinococcus granulosus	biogenic amine 5HT receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	nuclear receptor	0.0015	0.0064	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.005	0.0591	0.1131
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0034	0.036	0.0494
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0248	0.0262
Schistosoma mansoni	glutamate receptor kainate	0.0011	0.0013	0.0013
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0354	0.0375
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Brugia malayi	orphan nuclear receptor NR2E1	0.0015	0.0064	0.0087
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0093	0.1238	0.1311
Echinococcus multilocularis	regulator of G protein signaling 7	0.0011	0.0003	0.0003
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0022	0.0172	0.0324
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0011	0.0003	0.0004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0064	0.0801	0.0848
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0283	0.4102	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0064	0.0801	0.1099
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0159	0.0168
Echinococcus multilocularis	expressed protein	0.0011	0.0003	0.0003
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0022	0.0172	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.005	0.0591	0.081
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0034	0.036	0.036
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.005	0.0591	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0283	0.4102	0.5626
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0076	0.0992	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0571	0.0783
Brugia malayi	Phosphoglycerate kinase	0.0038	0.0413	0.0567
Schistosoma mansoni	regulator of G protein signaling	0.0011	0.0003	0.0003
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0159	0.0299
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0099	0.0099
Loa Loa (eye worm)	G-protein coupled receptor	0.0064	0.0801	0.1099
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0016	0.0084	0.0116
Echinococcus multilocularis	snurportin 1	0.0131	0.1819	0.1925
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0022	0.0172	0.0172
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0064	0.0067
Brugia malayi	hypothetical protein	0.0011	0.0003	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.036	0.036
Schistosoma mansoni	hypothetical protein	0.0637	0.9449	1
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0139	0.019
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.006	0.006
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0064	0.0067
Brugia malayi	G protein-coupled receptor	0.0064	0.0801	0.1099
Echinococcus granulosus	neuropeptide FF receptor 2	0.0064	0.0801	0.0848
Echinococcus granulosus	glutamate receptor 2	0.0013	0.0045	0.0048
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0064	0.0801	0.0848
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Plasmodium vivax	thioredoxin reductase, putative	0.0063	0.0794	0.313
Echinococcus granulosus	G protein coupled receptor 139	0.0064	0.0801	0.0848
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0159	0.0168
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0038	0.0413	0.0413
Echinococcus multilocularis	glutamate receptor 2	0.0011	0.0013	0.0013
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0011	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.005	0.0591	0.081
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0154	0.0211
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0031	0.0312	0.0428
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0026	0.0229	0.0229
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0494	0.0678
Echinococcus multilocularis	regulator of G protein signaling 7	0.0011	0.0003	0.0003
Schistosoma mansoni	zinc finger protein	0.0024	0.0198	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.006	0.006
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0011	0.0003	0.0003
Onchocerca volvulus		0.0064	0.0801	0.1021
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0103	0.1399	0.3643
Brugia malayi	putative neuropeptide receptor	0.0064	0.0801	0.1099
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0355	0.5192	1
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0129	0.0136
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0034	0.036	0.0381
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0031	0.0312	0.0428
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0072	0.0099
Echinococcus granulosus	axis inhibition protein axin	0.0011	0.0003	0.0003
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Schistosoma mansoni	hypothetical protein	0.0064	0.0801	0.0848
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Mycobacterium tuberculosis	Probable oxidoreductase	0.0022	0.0172	0.0324
Brugia malayi	hypothetical protein	0.0494	0.7291	1
Onchocerca volvulus		0.0064	0.0801	0.1021
Echinococcus multilocularis	G protein coupled receptor 139	0.0064	0.0801	0.0848
Echinococcus granulosus	histone lysine methyltransferase setb	0.0053	0.0641	0.0678
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0031	0.0312	0.033
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0392	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0034	0.036	0.0381
Onchocerca volvulus		0.005	0.0591	0.0729
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.0524	0.0555
Brugia malayi	PHD-finger family protein	0.003	0.0288	0.0394
Mycobacterium tuberculosis	Probable esterase LipL	0.005	0.0591	0.1131
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0154	0.0393
Schistosoma mansoni	biogenic amine receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.004	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0248	0.3583	0.4915
Mycobacterium leprae	conserved hypothetical protein	0.005	0.0591	0.3412
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0361	0.0496
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0034	0.036	0.1419
Loa Loa (eye worm)	glutamate receptor 2	0.0011	0.0013	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0154	0.0393
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0312	0.0428
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0494	0.0523
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0026	0.0229	0.0514
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0214	0.3066	0.3245
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0034	0.036	0.0494
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0332	0.0351
Echinococcus granulosus	neuropeptides capa receptor	0.0064	0.0801	0.0848
Echinococcus granulosus	nmda type glutamate receptor	0.0015	0.0067	0.0071
Trypanosoma cruzi	PAB1-binding protein , putative	0.002	0.0142	0.0142
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0107	0.1448	0.1532
Brugia malayi	exodeoxyribonuclease III family protein	0.0026	0.0229	0.0314
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0026	0.0229	0.0243
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0159	0.0159
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0034	0.036	0.036
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.1771	0.2429
Mycobacterium tuberculosis	Conserved protein	0.005	0.0591	0.1131
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0312	0.0428
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.0854	0.1172
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Brugia malayi	ecdysteroid receptor	0.0031	0.0312	0.0428
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0013	0.0045	0.0048
Leishmania major	trypanothione reductase	0.0063	0.0794	0.0794
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0064	0.0801	0.0848
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0034	0.036	0.036
Schistosoma mansoni	neuropeptide f receptor 76f	0.0064	0.0801	0.0848
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0064	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Plasmodium falciparum	phosphoglycerate kinase	0.0103	0.1399	0.5513
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0034	0.036	0.0381
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0072	0.0077
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0034	0.036	0.0381
Schistosoma mansoni	hypothetical protein	0.0637	0.9449	1
Onchocerca volvulus		0.0064	0.0801	0.1021
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0103	0.1399	0.1399
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0022	0.0172	0.0236
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0022	0.0173	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0169	0.2383	0.3269
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0103	0.1399	0.1481
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0103	0.1399	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0064	0.0801	0.1099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0064	0.0067
Echinococcus granulosus	neuropeptide receptor A26	0.0064	0.0801	0.0848
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0031	0.0312	0.0428
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0591	0.2327
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0022	0.0172	0.0677
Onchocerca volvulus		0.0064	0.0801	0.1021
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	amine GPCR	0.0064	0.0801	0.0848
Onchocerca volvulus	Huntingtin homolog	0.0197	0.281	0.38
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0034	0.036	0.0494
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0064	0.0067
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0034	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Giardia lamblia	Flap structure-specific endonuclease	0.0013	0.0031	0.003
Brugia malayi	Bromodomain containing protein	0.0085	0.113	0.155
Trichomonas vaginalis	flap endonuclease-1, putative	0.0013	0.0031	0.0074
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0159	0.0159
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0031	0.0312	0.033
Leishmania major	hypothetical protein, conserved	0.0034	0.036	0.036
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus granulosus	tm gpcr rhodopsin	0.0064	0.0801	0.0848
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0031	0.0312	0.033
Echinococcus multilocularis	dna polymerase eta	0.0036	0.0392	0.0415
Brugia malayi	F/Y-rich N-terminus family protein	0.0024	0.0197	0.027
Brugia malayi	Dopamine receptor	0.0064	0.0801	0.1099
Onchocerca volvulus		0.0064	0.0801	0.1021
Schistosoma mansoni	zinc finger protein	0.0015	0.0064	0.0067
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0011	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0016	0.009	0.0124
Schistosoma mansoni	glutamate receptor AMPA	0.0011	0.0013	0.0013
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0031	0.0312	0.033
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0332	0.081
Loa Loa (eye worm)	hypothetical protein	0.002	0.0142	0.0195
Echinococcus granulosus	Regulator of G protein signaling 20	0.0011	0.0003	0.0003
Schistosoma mansoni	hypothetical protein	0.0015	0.0072	0.0077
Echinococcus granulosus	thyroid hormone receptor alpha	0.0015	0.0064	0.0067
Onchocerca volvulus		0.0265	0.3836	0.5219
Chlamydia trachomatis	phosphoglycerate kinase	0.0103	0.1399	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0064	0.0801	0.0848
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus granulosus	expressed protein	0.0011	0.0003	0.0003
Onchocerca volvulus		0.0064	0.0801	0.1021
Trypanosoma cruzi	trypanothione reductase, putative	0.0063	0.0794	0.0794
Echinococcus multilocularis	neuropeptide Y receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	hypothetical protein	0.0033	0.0332	0.0351
Brugia malayi	jmjC domain containing protein	0.0107	0.1448	0.1985
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0031	0.0312	0.033
Brugia malayi	hypothetical protein	0.0015	0.0064	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0034	0.036	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0064	0.0801	0.0848
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.005	0.0591	0.1131
Plasmodium falciparum	ataxin-2 like protein, putative	0.002	0.0142	0.056
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0031	0.0312	0.0428
Toxoplasma gondii	thioredoxin reductase	0.0063	0.0794	0.1937
Onchocerca volvulus		0.0064	0.0801	0.1021
Echinococcus granulosus	phosphoglycerate kinase 1	0.0103	0.1399	0.1481
Echinococcus multilocularis	Protein lozenge	0.0062	0.0776	0.0821
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0034	0.036	0.0381
Onchocerca volvulus		0.004	0.0445	0.0528
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0034	0.036	0.0494
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0312	0.033
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0031	0.0312	0.033
Schistosoma mansoni	neuropeptide F-like receptor	0.0064	0.0801	0.0848
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0103	0.1399	0.3412
Brugia malayi	G protein-coupled receptor F59B2.13	0.0064	0.0801	0.1099
Echinococcus multilocularis	somatostatin receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.036	0.0932
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0034	0.036	0.0381
Echinococcus granulosus	tm gpcr rhodopsin	0.0064	0.0801	0.0848
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0068	0.0873	0.0924
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0862	0.0912
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0038	0.0413	0.0413
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0015	0.0064	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	myosin xvIII	0.0064	0.0801	0.0848
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0022	0.0172	0.0172
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0064	0.0801	0.0848
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0034	0.036	0.0381
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.009	0.0095
Trichomonas vaginalis	ap endonuclease, putative	0.0026	0.0229	0.059
Echinococcus multilocularis	fmrfamide receptor	0.0064	0.0801	0.0848
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0011	0.0013	0.0013
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0312	0.033
Loa Loa (eye worm)	hypothetical protein	0.0494	0.7291	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0022	0.0172	0.0172
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0064	0.0801	0.1099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0123	0.1703	0.1803
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0015	0.0064	0.0087
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0115	0.1583	0.1583
Schistosoma mansoni	biogenic amine receptor	0.0064	0.0801	0.0848
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0034	0.036	0.1419
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0095	0.127	0.127
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0011	0.0002	0.0002
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0022	0.0172	0.0182
Schistosoma mansoni	retinoic acid receptor RXR	0.023	0.3314	0.3508
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.005	0.0591	0.081
Trypanosoma brucei	unspecified product	0.0015	0.006	0.006
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0015	0.0064	0.0067
Brugia malayi	Dopamine receptor protein 1	0.0064	0.0801	0.1099
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.3836	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0031	0.0312	0.033
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0011	0.0007	0.0009
Schistosoma mansoni	neuropeptide F-like receptor	0.0064	0.0801	0.0848
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0312	0.0428
Trypanosoma brucei	importin beta-1 subunit, putative	0.0012	0.0027	0.0027
Onchocerca volvulus		0.0031	0.0312	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0033	0.034	0.0466
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0123	0.1703	0.1803
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0026	0.0229	0.0243
Echinococcus granulosus	peregrin	0.0035	0.0372	0.0394
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0034	0.036	0.0381
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0038	0.0413	0.0413
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0064	0.0801	0.0848
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0072	0.0077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0012	0.0019	0.002
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0034	0.036	0.036
Schistosoma mansoni	lozenge	0.0062	0.0776	0.0821
Onchocerca volvulus	Alhambra homolog	0.0033	0.0332	0.0372
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0022	0.0172	0.0182
Brugia malayi	ORL1-like opioid receptor	0.0064	0.0801	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0072	0.0099
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.005	0.0591	0.081
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	hypothetical protein	0.0169	0.2383	0.3269
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0068	0.0873	0.0924
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0034	0.036	0.036
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.1419
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.1419
Schistosoma mansoni	DNA polymerase eta	0.0036	0.0392	0.0415
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0123	0.1703	0.1803
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0325	0.0344
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.009	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	chromobox protein, putative	0.0022	0.0177	0.0455
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0103	0.1399	0.3412
Loa Loa (eye worm)	PXA domain-containing protein	0.0011	0.0003	0.0004
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0006	0.0007
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.036
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0064	0.0801	0.0848
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0022	0.0172	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0027	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	nuclear hormone receptor	0.0015	0.0064	0.0087
Onchocerca volvulus		0.0034	0.0361	0.0412
Plasmodium vivax	ataxin-2 like protein, putative	0.002	0.0142	0.056
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0013	0.0045	0.0048
Loa Loa (eye worm)	DR-78	0.0015	0.0064	0.0087
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	nuclear receptor RXR	0.0015	0.0064	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Leishmania major	macrophage migration inhibitory factor-like protein	0.0179	0.2538	0.2538
Echinococcus multilocularis	nmda type glutamate receptor	0.0015	0.0067	0.0071
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0107	0.1448	0.1532
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0014	0.0059	0.0062
Brugia malayi	G-protein coupled receptor	0.0064	0.0801	0.1099
Schistosoma mansoni	opsin-like receptor	0.0064	0.0801	0.0848
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0022	0.0177	0.0157
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	cpg binding protein	0.0035	0.0373	0.0395
Schistosoma mansoni	z-protein (S1r protein)	0.0011	0.0003	0.0003
Brugia malayi	MH2 domain containing protein	0.0128	0.1771	0.2429
Leishmania major	T-complex protein 1, beta subunit, putative	0.0012	0.0019	0.0019
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0248	0.0262
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0011	0.0003	0.0003
Echinococcus granulosus	cpg binding protein	0.0035	0.0373	0.0395
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0012	0.0019	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0031	0.0312	0.0428
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0012	0.0019	0.0076
Brugia malayi	beta-lactamase	0.005	0.0591	0.081
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0034	0.036	0.0381
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0446	0.0472
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0011	0.0003	0.0003
Onchocerca volvulus	Bile acid receptor homolog	0.0031	0.0312	0.0344
Toxoplasma gondii	NADPH-glutathione reductase	0.0022	0.0172	0.0419
Schistosoma mansoni	hypothetical protein	0.0034	0.0361	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.1419
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0674	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Brugia malayi	Dopamine receptor protein 2	0.0064	0.0801	0.1099
Brugia malayi	Bromodomain containing protein	0.0035	0.0372	0.051
Loa Loa (eye worm)	TYRA-2 protein	0.0064	0.0801	0.1099
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0022	0.0172	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	penicillin-binding protein, putative	0.005	0.0591	0.1534
Echinococcus granulosus	orexin receptor type 2	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0063	0.0156
Echinococcus granulosus	neuropeptide receptor	0.0064	0.0801	0.0848
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0012	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Brugia malayi	Bromodomain containing protein	0.0043	0.0486	0.0666
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0064	0.0801	0.1099
Echinococcus multilocularis	neuropeptide receptor	0.0064	0.0801	0.0848
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0312	0.033
Brugia malayi	chromobox protein homolog 3	0.0021	0.0154	0.0211
Brugia malayi	photoreceptor-specific nuclear receptor	0.0031	0.0312	0.0428
Plasmodium vivax	phosphodiesterase gamma, putative	0.0034	0.036	0.1419
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Plasmodium falciparum	flap endonuclease 1	0.0013	0.0031	0.0124
Schistosoma mansoni	hypothetical protein	0.0064	0.0801	0.0848
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0012	0.0019	0.0065
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0034	0.036	0.0381
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Schistosoma mansoni	bromodomain containing protein	0.0072	0.0933	0.0987
Schistosoma mansoni	RAR-like nuclear receptor	0.0031	0.0312	0.033
Brugia malayi	Melatonin receptor type 1A	0.0064	0.0801	0.1099
Leishmania major	hypothetical protein, conserved	0.002	0.0142	0.0142
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0072	0.0099
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0022	0.0172	0.0677
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0312	0.033
Echinococcus granulosus	zinc finger protein	0.0024	0.0198	0.0209
Brugia malayi	ImpB/MucB/SamB family protein	0.0036	0.0392	0.0538
Echinococcus granulosus	g protein coupled receptor	0.0064	0.0801	0.0848
Brugia malayi	Phosphoglycerate kinase	0.0103	0.1399	0.1919
Loa Loa (eye worm)	RGS-3 protein	0.0011	0.0003	0.0004
Echinococcus multilocularis	neuropeptide s receptor	0.0064	0.0801	0.0848
Brugia malayi	beta-lactamase family protein	0.005	0.0591	0.081
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Toxoplasma gondii	LsmAD domain-containing protein	0.002	0.0142	0.0346
Onchocerca volvulus	Protein ultraspiracle homolog	0.0031	0.0312	0.0344
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0129	0.0136
Schistosoma mansoni	adenoreceptor	0.0064	0.0801	0.0848
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Plasmodium vivax	phosphoglycerate kinase, putative	0.0103	0.1399	0.5513
Brugia malayi	RE15519p	0.0064	0.0801	0.1099
Onchocerca volvulus		0.0064	0.0801	0.1021
Echinococcus multilocularis	ecdysone induced protein 78C	0.0031	0.0312	0.033
Schistosoma mansoni	glutamate receptor NMDA	0.0011	0.0013	0.0013
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0034	0.036	0.0381
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0354	0.0863
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0283	0.4102	0.4341
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.009	0.0095
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0011	0.0003	0.0004
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0312	0.033
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Schistosoma mansoni	ATP-binding cassette transporter	0.0011	0.0013	0.0013
Trichomonas vaginalis	conserved hypothetical protein	0.0179	0.2538	0.6615
Toxoplasma gondii	HEAT repeat-containing protein	0.0012	0.0027	0.0066
Schistosoma mansoni	hypothetical protein	0.0015	0.0072	0.0077
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0034	0.036	0.0381
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0026	0.0229	0.1615
Schistosoma mansoni	zinc finger protein	0.0017	0.0099	0.0105
Onchocerca volvulus		0.0064	0.0801	0.1021
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0159	0.0218
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.036	0.036
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.004	0.0096
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0031	0.0121
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0034	0.036	0.0381
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0312	0.033
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0064	0.0801	0.0848
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0064	0.0801	0.0848
Trypanosoma cruzi	DNA polymerase eta, putative	0.0036	0.0392	0.0392
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0312	0.033
Plasmodium falciparum	macrophage migration inhibitory factor	0.0179	0.2538	1
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0189	0.0259
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0248	0.3583	0.3792
Echinococcus granulosus	GPCR family 2	0.0015	0.0072	0.0077
Echinococcus granulosus	dro:myosuppressin receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0063	0.0156
Loa Loa (eye worm)	hypothetical protein	0.005	0.0591	0.081
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0095	0.127	0.127
Brugia malayi	AKH receptor	0.0064	0.0801	0.1099
Loa Loa (eye worm)	flap endonuclease-1	0.0013	0.0031	0.0043
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.1399	0.1481
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0031	0.0312	0.0344
Brugia malayi	regulator of G-protein signaling rgs-7	0.0011	0.0003	0.0004
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0034	0.036	0.036
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0064	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0031	0.0312	0.0428
Brugia malayi	beta-lactamase family protein	0.005	0.0591	0.081
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Loa Loa (eye worm)	PDE1B protein	0.0034	0.036	0.0494
Echinococcus granulosus	geminin	0.0637	0.9449	1
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	importin beta-1	0.0012	0.0027	0.0029
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0013	0.0045	0.0048
Schistosoma mansoni	neuropeptide receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0312	0.0428
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0034	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0034	0.036	0.0494
Toxoplasma gondii	PHD-finger domain-containing protein	0.0011	0.0002	0.0005
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0064	0.0067
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.1399	0.1481
Echinococcus multilocularis	g-protein coupled receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0159	0.0407
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0022	0.0172	0.0419
Brugia malayi	hypothetical protein	0.0013	0.0036	0.0049
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0354	0.0375
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.005	0.0591	0.081
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0332	0.1308
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0034	0.036	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0123	0.1703	0.1803
Onchocerca volvulus		0.0064	0.0801	0.1021
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0022	0.0172	0.0172
Treponema pallidum	NADH oxidase	0.0022	0.0172	0.1204
Brugia malayi	hypothetical protein	0.0064	0.0801	0.1099
Toxoplasma gondii	ABC1 family protein	0.005	0.0591	0.144
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0031	0.0312	0.0428
Mycobacterium leprae	Probable lipase LipE	0.005	0.0591	0.3412
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0013	0.0045	0.0048
Plasmodium falciparum	thioredoxin reductase	0.0022	0.0172	0.0677
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0038	0.0413	0.0413
Schistosoma mansoni	hypothetical protein	0.0023	0.0189	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.036	0.0932
Brugia malayi	Serotonin receptor	0.0064	0.0801	0.1099
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0026	0.0229	0.0903
Plasmodium vivax	importin-beta 2, putative	0.0012	0.0027	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.0124
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0022	0.0172	0.0182
Schistosoma mansoni	axis inhibition protein axin	0.0011	0.0003	0.0003
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0034	0.036	0.0932
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0173	0.0173
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Giardia lamblia	Hypothetical protein	0.0034	0.036	0.0835
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0038	0.0413	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.0124
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0159	0.0168
Giardia lamblia	hypothetical protein	0.0034	0.036	0.0835
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0248	0.3583	0.4915
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0314	0.0431
Mycobacterium ulcerans	phosphoglycerate kinase	0.0103	0.1399	0.269
Echinococcus granulosus	beta LACTamase domain containing family member	0.005	0.0591	0.0625
Trypanosoma brucei	trypanothione reductase	0.0063	0.0794	0.0794
Mycobacterium ulcerans	hypothetical protein	0.005	0.0591	0.1131
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0026	0.0229	0.0892
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0179	0.2538	0.6188
Loa Loa (eye worm)	G-protein coupled receptor	0.0064	0.0801	0.1099
Leishmania major	macrophage migration inhibitory factor-like protein	0.0179	0.2538	0.2538
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0031	0.0312	0.033
Plasmodium vivax	SET domain protein, putative	0.0034	0.0354	0.1395
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0131	0.1819	0.2495
Toxoplasma gondii	t-complex protein beta subunit	0.0012	0.0019	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0103	0.1399	0.1399
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.009	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0031	0.0312	0.0428
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0064	0.0801	0.0848
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0012	0.0019	0.0019
Echinococcus multilocularis	g protein coupled receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.002	0.0138	0.0146
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0159	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0361	0.0496
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0011	0.0003	0.0003
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0031	0.0312	0.033
Brugia malayi	glutathione reductase	0.0063	0.0794	0.109
Schistosoma mansoni	phosphoglycerate kinase	0.0103	0.1399	0.1481
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0022	0.0172	0.0172
Onchocerca volvulus	Cell death protein 3 homolog	0.0034	0.0361	0.0412
Echinococcus granulosus	chromobox protein 1	0.0037	0.0398	0.0421
Onchocerca volvulus		0.005	0.0591	0.0729
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Leishmania major	hypothetical protein, conserved	0.0034	0.036	0.036
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0064	0.0801	0.0848
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0248	0.3583	0.3792
Loa Loa (eye worm)	glutamate receptor 1	0.0011	0.0013	0.0017
Trypanosoma brucei	hypothetical protein, conserved	0.0034	0.036	0.036
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0064	0.0801	0.1021
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0332	0.081
Onchocerca volvulus		0.0494	0.7291	1
Mycobacterium ulcerans	esterase/lipase LipP	0.005	0.0591	0.1131
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0103	0.1399	1
Echinococcus granulosus	neuropeptide Y receptor	0.0064	0.0801	0.0848
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0095	0.127	0.127
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0332	0.0455
Brugia malayi	hypothetical protein	0.0197	0.281	0.3854
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.036	0.036
Echinococcus multilocularis	neuropeptide receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.005	0.0591	0.0625
Trichomonas vaginalis	mercuric reductase, putative	0.0022	0.0172	0.0441
Echinococcus granulosus	caspase 2	0.0034	0.0361	0.0382
Onchocerca volvulus		0.0064	0.0801	0.1021
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0034	0.036	0.0381
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0076	0.0992	0.1361
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus granulosus	allatostatin A receptor	0.0064	0.0801	0.0848
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0022	0.0172	0.0324
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0064	0.0801	0.1099
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0013	0.0045	0.0048
Echinococcus granulosus	apoptotic protease activating factor 1	0.0034	0.0361	0.0383
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0034	0.036	0.036
Trypanosoma brucei	unspecified product	0.0021	0.0159	0.0159
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0015	0.0064	0.0087
Brugia malayi	putative neuropeptide receptor NPR1	0.0064	0.0801	0.1099
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0026	0.0229	0.0229
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0013	0.0031	0.0031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0012	0.0019	0.002
Echinococcus multilocularis	g protein coupled receptor	0.0064	0.0801	0.0848
Echinococcus granulosus	sex peptide receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	nuclear hormone receptor	0.0015	0.0064	0.0087
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0022	0.0172	0.0324
Echinococcus multilocularis	peregrin	0.0035	0.0372	0.0394
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0064	0.0801	0.1099
Leishmania major	DNA polymerase eta, putative	0.0022	0.0173	0.0173
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Onchocerca volvulus		0.0064	0.0801	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.0124
Schistosoma mansoni	glutamate receptor kainate	0.0011	0.0013	0.0013
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0026	0.0229	0.0434
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Trichomonas vaginalis	chromobox protein, putative	0.0022	0.0177	0.0455
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.034	0.0466
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0064	0.0087
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Plasmodium vivax	flap endonuclease 1, putative	0.0013	0.0031	0.0124
Brugia malayi	T-complex protein 1, beta subunit	0.0012	0.0019	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.036	0.036
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0015	0.0064	0.0087
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trichomonas vaginalis	D-aminoacylase, putative	0.005	0.0591	0.1534
Mycobacterium tuberculosis	Probable lipase LipD	0.005	0.0591	0.1131
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus granulosus	neuropeptides capa receptor	0.0064	0.0801	0.0848
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0034	0.036	0.0494
Echinococcus multilocularis	g protein coupled receptor	0.0064	0.0801	0.0848
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0038	0.0413	0.0413
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0031	0.0312	0.0428
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.009	0.0095
Brugia malayi	Flap endonuclease-1	0.0013	0.0031	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0591	0.0591
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0053	0.0641	0.0678
Mycobacterium ulcerans	beta-lactamase	0.005	0.0591	0.1131
Brugia malayi	G-protein coupled receptor	0.0064	0.0801	0.1099
Brugia malayi	hypothetical protein	0.002	0.0142	0.0195
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0312	0.0428
Schistosoma mansoni	regulator of G protein signaling	0.0011	0.0003	0.0003
Echinococcus multilocularis	geminin	0.0637	0.9449	1
Brugia malayi	PHD-finger family protein	0.0033	0.0332	0.0455
Giardia lamblia	Macrophage migration inhibitory factor	0.0179	0.2538	0.617
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.004	0.0096
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0591	0.0591
Brugia malayi	nuclear hormone receptor	0.0031	0.0312	0.0428
Brugia malayi	Heterochromatin protein 1	0.0037	0.0398	0.0546
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0129	0.0136
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0123	0.1703	0.2336
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.0932
Echinococcus granulosus	chromobox protein 1	0.0037	0.0398	0.0421
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0064	0.0801	0.0848
Echinococcus granulosus	g protein coupled receptor	0.0064	0.0801	0.0848
Brugia malayi	ecdysone receptor	0.0015	0.0064	0.0087
Schistosoma mansoni	regulator of G protein signaling	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.005	0.0591	0.081
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0248	0.0262
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0063	0.0794	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus multilocularis	flap endonuclease 1	0.0013	0.0031	0.0033
Echinococcus granulosus	rhodopsin orphan GPCR	0.0064	0.0801	0.0848
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0026	0.0229	0.0467
Schistosoma mansoni	growth hormone secretagogue receptor	0.0064	0.0801	0.0848
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0571	0.0783
Echinococcus granulosus	regulator of G protein signaling 7	0.0011	0.0003	0.0003
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0034	0.036	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0682	0.0936
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0011	0.0002	0.0002
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0571	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Echinococcus granulosus	dna polymerase eta	0.0036	0.0392	0.0415
Mycobacterium ulcerans	hypothetical protein	0.0355	0.5192	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0026	0.0229	0.0434
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0031	0.0312	0.033
Echinococcus multilocularis	regulator of G protein signaling 3	0.0011	0.0003	0.0003
Onchocerca volvulus		0.0064	0.0801	0.1021
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0064	0.0801	0.0848
Echinococcus granulosus	7TM GPCR rhodopsin	0.0064	0.0801	0.0848
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0063	0.0794	0.1524
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.1419
Brugia malayi	nuclear receptor RXR	0.0016	0.009	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0314	0.0431
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Brugia malayi	tailless protein	0.0015	0.0064	0.0087
Trypanosoma brucei	ISWI complex protein	0.0017	0.0099	0.0099
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Schistosoma mansoni	axis inhibition protein axin	0.0011	0.0003	0.0003
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0022	0.0172	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0031	0.0312	0.0428
Brugia malayi	neuropeptide F receptor	0.0064	0.0801	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0179	0.2538	0.6615
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0015	0.0064	0.0067
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0179	0.2538	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Echinococcus multilocularis	dro:myosuppressin receptor	0.0064	0.0801	0.0848
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Onchocerca volvulus		0.0016	0.0086	0.0031
Echinococcus multilocularis	allatostatin A receptor	0.0064	0.0801	0.0848
Brugia malayi	hypothetical protein	0.0015	0.0064	0.0087
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0398	0.1031
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0641	0.0678
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.004	0.0445	0.0471
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0013	0.0045	0.0048
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0034	0.036	0.0932
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0034	0.036	0.036
Giardia lamblia	Phosphoglycerate kinase	0.0103	0.1399	0.338
Echinococcus multilocularis	serotonin receptor	0.0064	0.0801	0.0848
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0014	0.0059	0.0062
Echinococcus granulosus	nuclear receptor nhr 48	0.0015	0.0064	0.0067
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.004	0.0096
Onchocerca volvulus		0.0031	0.0314	0.0346
Echinococcus granulosus	tm gpcr rhodopsin	0.0064	0.0801	0.0848
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0072	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0086	0.0118
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Plasmodium falciparum	ataxin-2 like protein, putative	0.002	0.0142	0.056
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0064	0.0801	0.0848
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0072	0.0099
Echinococcus granulosus	hypothetical protein	0.0064	0.0801	0.0848
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0435	0.0461
Loa Loa (eye worm)	heterochromatin protein 1	0.0037	0.0398	0.0546
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0123	0.1703	0.2336
Loa Loa (eye worm)	hypothetical protein	0.0034	0.036	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0026	0.0229	0.0314
Plasmodium falciparum	thioredoxin reductase	0.0063	0.0794	0.313
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0022	0.0172	0.0172
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0159	0.0159
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0021	0.0154	0.0125
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0312	0.0428
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0159	0.0168
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0319	0.4649	0.4649
Echinococcus granulosus	somatostatin receptor	0.0064	0.0801	0.0848
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0016	0.0084	0.0116
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0571	0.0783
Schistosoma mansoni	biogenic amine receptor	0.0064	0.0801	0.0848
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0012	0.0019	0.002
Treponema pallidum	phosphoglycerate kinase	0.0103	0.1399	1
Onchocerca volvulus		0.0064	0.0801	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0197	0.281	0.3854
Toxoplasma gondii	exonuclease III APE	0.0026	0.0229	0.0559
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0064	0.0801	0.0848
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0034	0.036	0.0878
Brugia malayi	AF-10 protein	0.0011	0.0002	0.0003
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0064	0.0801	0.1099
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0064	0.0801	0.0848
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0031	0.0312	0.033
Echinococcus multilocularis	cpg binding protein	0.0035	0.0373	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0064	0.0087
Echinococcus multilocularis	fmrfamide receptor	0.0064	0.0801	0.0848
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0034	0.036	0.0381
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0093	0.1238	0.1311
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0011	0.0002	0.0005
Brugia malayi	follicle stimulating hormone receptor	0.0064	0.0801	0.1099
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.005	0.0591	0.1131
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0038	0.0413	0.0413
Brugia malayi	neuropeptide F receptor	0.0064	0.0801	0.1099
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0317	0.4627	0.891
Trypanosoma brucei	unspecified product	0.0015	0.006	0.006
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0064	0.0801	0.0848
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0283	0.4102	0.4341
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0159	0.0299
Toxoplasma gondii	hypothetical protein	0.0109	0.148	0.3609
Onchocerca volvulus	Huntingtin homolog	0.0197	0.281	0.38
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0034	0.036	0.1419
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0123	0.1703	0.1803
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1399	0.1919
Brugia malayi	RNA, U transporter 1	0.0035	0.0369	0.0505
Schistosoma mansoni	jumonji domain containing protein	0.0085	0.1118	0.1183
Echinococcus multilocularis	zinc finger protein	0.0024	0.0198	0.0209
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0011	0.0003	0.0003
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0494	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0801	0.1099
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0064	0.0801	0.1099

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 2.9 uM	Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.	ChEMBL.	14592508
Ki (binding)	= 2.9 uM	Inhibition of HCV (Hepatitis C Virus) NS3-4A protease.	ChEMBL.	14592508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 226173