Detailed information for compound 226908

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 644.76 | Formula: C35H44N6O6
  • H donors: 3 H acceptors: 7 LogP: 3.63 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)c1cnccn1)OCc1ccc2c(c1)cccc2)C=O
  • InChi: 1S/C35H44N6O6/c1-6-26(19-42)38-33(44)29-16-27(47-20-23-11-12-24-9-7-8-10-25(24)15-23)18-41(29)35(46)31(22(4)5)40-34(45)30(21(2)3)39-32(43)28-17-36-13-14-37-28/h7-15,17,19,21-22,26-27,29-31H,6,16,18,20H2,1-5H3,(H,38,44)(H,39,43)(H,40,45)/t26-,27+,29-,30+,31+/m0/s1
  • InChiKey: XVTHVTNFGGJYAA-BHPKKYGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus serine protease, NS3/NS4A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica hypothetical protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 52 aa 23.1 %
Toxoplasma gondii hypothetical protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 50 aa 28.0 %
Trypanosoma brucei hypothetical protein, conserved Hepatitis C virus serine protease, NS3/NS4A   54 aa 55 aa 30.9 %
Trypanosoma brucei gambiense expression site-associated gene 3 (ESAG3)-like protein, putative Hepatitis C virus serine protease, NS3/NS4A   54 aa 49 aa 28.6 %
Leishmania braziliensis hypothetical protein, conserved Hepatitis C virus serine protease, NS3/NS4A   54 aa 46 aa 26.1 %
Mycobacterium ulcerans Maf-like protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 44 aa 38.6 %
Schistosoma japonicum expressed protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 44 aa 29.5 %
Echinococcus granulosus 60S ribosomal protein L8 Hepatitis C virus serine protease, NS3/NS4A   54 aa 48 aa 33.3 %
Trypanosoma brucei expression site-associated gene 3 (ESAG3)-like protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 49 aa 28.6 %
Schistosoma mansoni hypothetical protein Hepatitis C virus serine protease, NS3/NS4A   54 aa 44 aa 29.5 %
Mycobacterium tuberculosis Membrane-associated phospholipase C 2 PlcB Hepatitis C virus serine protease, NS3/NS4A   54 aa 49 aa 32.7 %
Trypanosoma congolense WD40 repeats, putative Hepatitis C virus serine protease, NS3/NS4A   54 aa 46 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0172 0.1204
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0064 0.0801 0.0848
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0007
Loa Loa (eye worm) PXA domain-containing protein 0.0011 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0177 0.0455
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.009 0.0124
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0325 0.0344
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0103 0.1399 0.3412
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Leishmania major cAMP-specific phosphodiesterase, putative 0.0034 0.036 0.036
Brugia malayi hypothetical protein 0.0169 0.2383 0.3269
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0873 0.0924
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0123 0.1703 0.1803
Schistosoma mansoni DNA polymerase eta 0.0036 0.0392 0.0415
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.1419
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.1419
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0172 0.0182
Brugia malayi ORL1-like opioid receptor 0.0064 0.0801 0.1099
Onchocerca volvulus Alhambra homolog 0.0033 0.0332 0.0372
Schistosoma mansoni lozenge 0.0062 0.0776 0.0821
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0034 0.036 0.036
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0012 0.0019 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.005 0.0591 0.081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0072 0.0099
Brugia malayi beta-lactamase 0.005 0.0591 0.081
Plasmodium falciparum T-complex protein 1 subunit beta 0.0012 0.0019 0.0076
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0312 0.0428
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0012 0.0019 0.0076
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0172 0.0419
Schistosoma mansoni hypothetical protein 0.0034 0.0361 0.0383
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0011 0.0003 0.0003
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0312 0.0344
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0446 0.0472
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0034 0.036 0.0381
Leishmania major T-complex protein 1, beta subunit, putative 0.0012 0.0019 0.0019
Brugia malayi MH2 domain containing protein 0.0128 0.1771 0.2429
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0035 0.0373 0.0395
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0022 0.0177 0.0157
Echinococcus granulosus cpg binding protein 0.0035 0.0373 0.0395
Echinococcus multilocularis Regulator of G protein signaling 20 0.0011 0.0003 0.0003
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0248 0.0262
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0067 0.0071
Leishmania major macrophage migration inhibitory factor-like protein 0.0179 0.2538 0.2538
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi nuclear receptor RXR 0.0015 0.0064 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Brugia malayi G-protein coupled receptor 0.0064 0.0801 0.1099
Schistosoma mansoni opsin-like receptor 0.0064 0.0801 0.0848
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0059 0.0062
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1448 0.1532
Onchocerca volvulus 0.0034 0.0361 0.0412
Brugia malayi nuclear hormone receptor 0.0015 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) DR-78 0.0015 0.0064 0.0087
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0013 0.0045 0.0048
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0142 0.056
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0034 0.036 0.0381
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.009 0.0095
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.0801 0.0848
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0172 0.0172
Schistosoma mansoni myosin xvIII 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0064 0.0087
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0413 0.0413
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0229 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.036 0.0932
Echinococcus multilocularis somatostatin receptor 0.0064 0.0801 0.0848
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.0801 0.1099
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0103 0.1399 0.3412
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0862 0.0912
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0873 0.0924
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0034 0.036 0.0381
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0801 0.0848
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0034 0.036 0.0494
Onchocerca volvulus 0.004 0.0445 0.0528
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0034 0.036 0.0381
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0312 0.033
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0801 0.0848
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0312 0.033
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0034 0.036 0.0932
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0034 0.036 0.0381
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis Protein lozenge 0.0062 0.0776 0.0821
Onchocerca volvulus 0.0064 0.0801 0.1021
Echinococcus granulosus phosphoglycerate kinase 1 0.0103 0.1399 0.1481
Toxoplasma gondii thioredoxin reductase 0.0063 0.0794 0.1937
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.005 0.0591 0.1131
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0312 0.0428
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0142 0.056
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0034 0.036 0.0381
Echinococcus granulosus peregrin 0.0035 0.0372 0.0394
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0026 0.0229 0.0243
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0123 0.1703 0.1803
Loa Loa (eye worm) hypothetical protein 0.0033 0.034 0.0466
Onchocerca volvulus 0.0031 0.0312 0.0344
Trypanosoma brucei importin beta-1 subunit, putative 0.0012 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0312 0.0428
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0072 0.0077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0801 0.0848
Leishmania major DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0038 0.0413 0.0413
Trichomonas vaginalis set domain proteins, putative 0.0265 0.3836 1
Brugia malayi Dopamine receptor protein 1 0.0064 0.0801 0.1099
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0011 0.0007 0.0009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0312 0.033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0801 0.0848
Schistosoma mansoni retinoic acid receptor RXR 0.023 0.3314 0.3508
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0172 0.0182
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0002 0.0002
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0064 0.0067
Trypanosoma brucei unspecified product 0.0015 0.006 0.006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.005 0.0591 0.081
Loa Loa (eye worm) hypothetical protein 0.0494 0.7291 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0312 0.033
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0011 0.0013 0.0013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0095 0.127 0.127
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0034 0.036 0.1419
Schistosoma mansoni biogenic amine receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0064 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0115 0.1583 0.1583
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.0801 0.1099
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0123 0.1703 0.1803
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0172 0.0172
Brugia malayi regulator of G-protein signaling rgs-7 0.0011 0.0003 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0312 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1399 0.1481
Loa Loa (eye worm) flap endonuclease-1 0.0013 0.0031 0.0043
Brugia malayi AKH receptor 0.0064 0.0801 0.1099
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0064 0.0067
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0034 0.036 0.036
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0248 0.3583 0.3792
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0189 0.0259
Plasmodium falciparum macrophage migration inhibitory factor 0.0179 0.2538 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0312 0.033
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0095 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.005 0.0591 0.081
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0156
Echinococcus granulosus GPCR family 2 0.0015 0.0072 0.0077
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.036 0.036
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0159 0.0218
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0392 0.0392
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0801 0.0848
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0312 0.033
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0031 0.0121
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0034 0.036 0.0381
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0096
Schistosoma mansoni hypothetical protein 0.0015 0.0072 0.0077
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0027 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.2538 0.6615
Schistosoma mansoni ATP-binding cassette transporter 0.0011 0.0013 0.0013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0312 0.033
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Onchocerca volvulus 0.0064 0.0801 0.1021
Schistosoma mansoni zinc finger protein 0.0017 0.0099 0.0105
Treponema pallidum exodeoxyribonuclease (exoA) 0.0026 0.0229 0.1615
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0034 0.036 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0312 0.0428
Toxoplasma gondii ABC1 family protein 0.005 0.0591 0.144
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Plasmodium falciparum thioredoxin reductase 0.0022 0.0172 0.0677
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0013 0.0045 0.0048
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Mycobacterium leprae Probable lipase LipE 0.005 0.0591 0.3412
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Treponema pallidum NADH oxidase 0.0022 0.0172 0.1204
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0172 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0123 0.1703 0.1803
Onchocerca volvulus 0.0064 0.0801 0.1021
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0034 0.036 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0332 0.1308
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0064 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1399 0.1481
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.036 0.0494
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0034 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.005 0.0591 0.081
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0159 0.0159
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Brugia malayi hypothetical protein 0.0013 0.0036 0.0049
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0354 0.0375
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0172 0.0419
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0159 0.0407
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi beta-lactamase family protein 0.005 0.0591 0.081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0312 0.0428
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0013 0.0045 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Schistosoma mansoni neuropeptide receptor 0.0064 0.0801 0.0848
Schistosoma mansoni importin beta-1 0.0012 0.0027 0.0029
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) PDE1B protein 0.0034 0.036 0.0494
Echinococcus granulosus geminin 0.0637 0.9449 1
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Plasmodium vivax phosphodiesterase gamma, putative 0.0034 0.036 0.1419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.0801 0.0848
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0034 0.036 0.0381
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0012 0.0019 0.0065
Schistosoma mansoni hypothetical protein 0.0064 0.0801 0.0848
Plasmodium falciparum flap endonuclease 1 0.0013 0.0031 0.0124
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0801 0.0848
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.0801 0.1099
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Brugia malayi Bromodomain containing protein 0.0043 0.0486 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0312 0.0428
Brugia malayi chromobox protein homolog 3 0.0021 0.0154 0.0211
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0312 0.033
Echinococcus granulosus orexin receptor type 2 0.0064 0.0801 0.0848
Trichomonas vaginalis penicillin-binding protein, putative 0.005 0.0591 0.1534
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0172 0.0324
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.0801 0.1099
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0012 0.0019 0.0019
Echinococcus granulosus neuropeptide receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0156
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0674 1 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.1419
Brugia malayi Bromodomain containing protein 0.0035 0.0372 0.051
Brugia malayi Dopamine receptor protein 2 0.0064 0.0801 0.1099
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.0801 0.0848
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0283 0.4102 0.4341
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0354 0.0863
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0034 0.036 0.0381
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0003 0.0004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.009 0.0095
Brugia malayi RE15519p 0.0064 0.0801 0.1099
Plasmodium vivax phosphoglycerate kinase, putative 0.0103 0.1399 0.5513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0013 0.0013
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0312 0.033
Onchocerca volvulus 0.0064 0.0801 0.1021
Brugia malayi beta-lactamase family protein 0.005 0.0591 0.081
Echinococcus multilocularis neuropeptide s receptor 0.0064 0.0801 0.0848
Brugia malayi Phosphoglycerate kinase 0.0103 0.1399 0.1919
Loa Loa (eye worm) RGS-3 protein 0.0011 0.0003 0.0004
Echinococcus granulosus g protein coupled receptor 0.0064 0.0801 0.0848
Schistosoma mansoni adenoreceptor 0.0064 0.0801 0.0848
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0129 0.0136
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0312 0.0344
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0142 0.0346
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Leishmania major hypothetical protein, conserved 0.002 0.0142 0.0142
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0312 0.033
Brugia malayi Melatonin receptor type 1A 0.0064 0.0801 0.1099
Schistosoma mansoni bromodomain containing protein 0.0072 0.0933 0.0987
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0392 0.0538
Echinococcus granulosus zinc finger protein 0.0024 0.0198 0.0209
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0312 0.033
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0172 0.0677
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0072 0.0099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0801 0.0848
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0172 0.0324
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0064 0.0087
Echinococcus granulosus sex peptide receptor 0.0064 0.0801 0.0848
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0013 0.0031 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0012 0.0019 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0064 0.0087
Trypanosoma brucei unspecified product 0.0021 0.0159 0.0159
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.036 0.036
Echinococcus granulosus apoptotic protease activating factor 1 0.0034 0.0361 0.0383
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0013 0.0045 0.0048
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.0801 0.1099
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0172 0.0324
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0026 0.0229 0.0229
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.0801 0.1099
Echinococcus granulosus caspase 2 0.0034 0.0361 0.0382
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0172 0.0441
Echinococcus multilocularis neuropeptide receptor 0.0064 0.0801 0.0848
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.005 0.0591 0.0625
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Brugia malayi hypothetical protein 0.0197 0.281 0.3854
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0332 0.0455
Echinococcus granulosus allatostatin A receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0034 0.036 0.0932
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0076 0.0992 0.1361
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0034 0.036 0.0381
Onchocerca volvulus 0.0064 0.0801 0.1021
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0641 0.0678
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Echinococcus multilocularis geminin 0.0637 0.9449 1
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0003 0.0003
Brugia malayi nuclear receptor NHR-88 0.0031 0.0312 0.0428
Brugia malayi hypothetical protein 0.002 0.0142 0.0195
Brugia malayi G-protein coupled receptor 0.0064 0.0801 0.1099
Mycobacterium ulcerans beta-lactamase 0.005 0.0591 0.1131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0312 0.0428
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0413 0.0413
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0801 0.0848
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0034 0.036 0.0494
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Mycobacterium tuberculosis Probable lipase LipD 0.005 0.0591 0.1131
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Brugia malayi Flap endonuclease-1 0.0013 0.0031 0.0043
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.009 0.0095
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Brugia malayi T-complex protein 1, beta subunit 0.0012 0.0019 0.0027
Plasmodium vivax flap endonuclease 1, putative 0.0013 0.0031 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0591 0.1534
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0064 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Leishmania major DNA polymerase eta, putative 0.0022 0.0173 0.0173
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.0801 0.1099
Echinococcus multilocularis peregrin 0.0035 0.0372 0.0394
Brugia malayi nuclear receptor NHR-88 0.0015 0.0064 0.0087
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.034 0.0466
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0177 0.0455
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Schistosoma mansoni glutamate receptor kainate 0.0011 0.0013 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0026 0.0229 0.0434
Onchocerca volvulus 0.0064 0.0801 0.1021
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0124
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0312 0.033
Leishmania major macrophage migration inhibitory factor-like protein 0.0179 0.2538 0.2538
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0801 0.1099
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0179 0.2538 0.6188
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0026 0.0229 0.0892
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.1399 0.1399
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0131 0.1819 0.2495
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Toxoplasma gondii t-complex protein beta subunit 0.0012 0.0019 0.0047
Plasmodium vivax SET domain protein, putative 0.0034 0.0354 0.1395
Mycobacterium ulcerans phosphoglycerate kinase 0.0103 0.1399 0.269
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0314 0.0431
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0248 0.3583 0.4915
Mycobacterium ulcerans hypothetical protein 0.005 0.0591 0.1131
Trypanosoma brucei trypanothione reductase 0.0063 0.0794 0.0794
Echinococcus granulosus beta LACTamase domain containing family member 0.005 0.0591 0.0625
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0159 0.0168
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0124
Trypanosoma brucei phosphoglycerate kinase, putative 0.0038 0.0413 0.0413
Giardia lamblia Hypothetical protein 0.0034 0.036 0.0835
Giardia lamblia hypothetical protein 0.0034 0.036 0.0835
Plasmodium vivax importin-beta 2, putative 0.0012 0.0027 0.0106
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0229 0.0903
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Brugia malayi Serotonin receptor 0.0064 0.0801 0.1099
Schistosoma mansoni hypothetical protein 0.0023 0.0189 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.036 0.0932
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0413 0.0413
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0173 0.0173
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0034 0.036 0.0932
Schistosoma mansoni axis inhibition protein axin 0.0011 0.0003 0.0003
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0172 0.0182
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0124
Onchocerca volvulus 0.0494 0.7291 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0332 0.081
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.0801 0.1021
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0095 0.127 0.127
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0801 0.0848
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0103 0.1399 1
Mycobacterium ulcerans esterase/lipase LipP 0.005 0.0591 0.1131
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.0801 0.0848
Leishmania major hypothetical protein, conserved 0.0034 0.036 0.036
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.036 0.036
Loa Loa (eye worm) glutamate receptor 1 0.0011 0.0013 0.0017
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0248 0.3583 0.3792
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0172 0.0172
Onchocerca volvulus Cell death protein 3 homolog 0.0034 0.0361 0.0412
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.1399 0.1481
Brugia malayi glutathione reductase 0.0063 0.0794 0.109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Onchocerca volvulus 0.005 0.0591 0.0729
Echinococcus granulosus chromobox protein 1 0.0037 0.0398 0.0421
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0159 0.0407
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0138 0.0146
Echinococcus multilocularis g protein coupled receptor 0.0064 0.0801 0.0848
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0012 0.0019 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0312 0.0428
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.009 0.0124
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0312 0.033
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0361 0.0496
Toxoplasma gondii exonuclease III APE 0.0026 0.0229 0.0559
Onchocerca volvulus 0.0064 0.0801 0.1021
Loa Loa (eye worm) hypothetical protein 0.0197 0.281 0.3854
Treponema pallidum phosphoglycerate kinase 0.0103 0.1399 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0801 0.0848
Brugia malayi AF-10 protein 0.0011 0.0002 0.0003
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.0801 0.1099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Echinococcus granulosus tachykinin peptides receptor 99D 0.0064 0.0801 0.0848
Echinococcus granulosus somatostatin receptor 0.0064 0.0801 0.0848
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0319 0.4649 0.4649
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0159 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0312 0.0428
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0021 0.0154 0.0125
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0012 0.0019 0.002
Schistosoma mansoni biogenic amine receptor 0.0064 0.0801 0.0848
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0084 0.0116
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0571 0.0783
Plasmodium falciparum thioredoxin reductase 0.0063 0.0794 0.313
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0026 0.0229 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0072 0.0077
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0801 0.0848
Onchocerca volvulus 0.0031 0.0314 0.0346
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0123 0.1703 0.2336
Loa Loa (eye worm) hypothetical protein 0.0034 0.036 0.0494
Loa Loa (eye worm) heterochromatin protein 1 0.0037 0.0398 0.0546
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0435 0.0461
Echinococcus granulosus hypothetical protein 0.0064 0.0801 0.0848
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0072 0.0099
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0142 0.056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.0801 0.1099
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni jumonji domain containing protein 0.0085 0.1118 0.1183
Brugia malayi RNA, U transporter 1 0.0035 0.0369 0.0505
Loa Loa (eye worm) hypothetical protein 0.0103 0.1399 0.1919
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0123 0.1703 0.1803
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0034 0.036 0.1419
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0494 0.0523
Echinococcus multilocularis zinc finger protein 0.0024 0.0198 0.0209
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0159 0.0299
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0283 0.4102 0.4341
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.0801 0.0848
Trypanosoma brucei unspecified product 0.0015 0.006 0.006
Onchocerca volvulus Huntingtin homolog 0.0197 0.281 0.38
Toxoplasma gondii hypothetical protein 0.0109 0.148 0.3609
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0002 0.0005
Echinococcus granulosus G protein coupled receptor kinase 1 0.0093 0.1238 0.1311
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0034 0.036 0.0381
Echinococcus multilocularis fmrfamide receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis cpg binding protein 0.0035 0.0373 0.0395
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0312 0.033
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0317 0.4627 0.891
Brugia malayi neuropeptide F receptor 0.0064 0.0801 0.1099
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.0413 0.0413
Brugia malayi follicle stimulating hormone receptor 0.0064 0.0801 0.1099
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.005 0.0591 0.1131
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0034 0.036 0.0494
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0571 0.0783
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0056 0.0682 0.0936
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0248 0.0262
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0003 0.0003
Brugia malayi ecdysone receptor 0.0015 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.005 0.0591 0.081
Echinococcus granulosus g protein coupled receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0801 0.0848
Echinococcus granulosus chromobox protein 1 0.0037 0.0398 0.0421
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0026 0.0229 0.0467
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Echinococcus multilocularis flap endonuclease 1 0.0013 0.0031 0.0033
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.0794 0.0841
Brugia malayi Heterochromatin protein 1 0.0037 0.0398 0.0546
Brugia malayi nuclear hormone receptor 0.0031 0.0312 0.0428
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0591 0.0591
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0123 0.1703 0.2336
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0129 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Brugia malayi PHD-finger family protein 0.0033 0.0332 0.0455
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.004 0.0096
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Giardia lamblia Macrophage migration inhibitory factor 0.0179 0.2538 0.617
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0641 0.0678
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0398 0.1031
Brugia malayi hypothetical protein 0.0015 0.0064 0.0087
Echinococcus multilocularis allatostatin A receptor 0.0064 0.0801 0.0848
Onchocerca volvulus 0.0016 0.0086 0.0031
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0064 0.0067
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.004 0.0096
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0059 0.0062
Echinococcus multilocularis serotonin receptor 0.0064 0.0801 0.0848
Giardia lamblia Phosphoglycerate kinase 0.0103 0.1399 0.338
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.036
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0013 0.0045 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0445 0.0471
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0179 0.2538 0.6615
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0312 0.0428
Brugia malayi neuropeptide F receptor 0.0064 0.0801 0.1099
Schistosoma mansoni axis inhibition protein axin 0.0011 0.0003 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0172 0.0324
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.0801 0.0848
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0179 0.2538 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0064 0.0067
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Brugia malayi CXXC zinc finger family protein 0.0031 0.0314 0.0431
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trypanosoma brucei ISWI complex protein 0.0017 0.0099 0.0099
Brugia malayi tailless protein 0.0015 0.0064 0.0087
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0026 0.0229 0.0434
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Echinococcus granulosus dna polymerase eta 0.0036 0.0392 0.0415
Mycobacterium ulcerans hypothetical protein 0.0355 0.5192 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0002 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0571 0.0783
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi nuclear receptor RXR 0.0016 0.009 0.0124
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.1419
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0794 0.1524
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.0801 0.0848
Onchocerca volvulus 0.0064 0.0801 0.1021
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.0801 0.0848
Echinococcus multilocularis regulator of G protein signaling 3 0.0011 0.0003 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0312 0.033
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0283 0.4102 0.4341
Brugia malayi larval opioid receptor 0.0064 0.0801 0.1099
Schistosoma mansoni glutamate receptor NMDA 0.0013 0.0045 0.0048
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Brugia malayi sulfakinin receptor protein 0.0064 0.0801 0.1099
Schistosoma mansoni glutamate receptor AMPA 0.0011 0.0013 0.0013
Echinococcus granulosus fmrfamide receptor 0.0064 0.0801 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0312 0.0428
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0064 0.0087
Schistosoma mansoni opsin-like receptor 0.0064 0.0801 0.0848
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.1399 0.1399
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0179 0.2538 0.3481
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0064 0.0067
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis chromobox protein 1 0.0037 0.0398 0.0421
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0283 0.4102 0.4341
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Mycobacterium tuberculosis Conserved protein 0.005 0.0591 0.1131
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.0801 0.1099
Echinococcus granulosus g-protein coupled receptor 0.0064 0.0801 0.0848
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0034 0.036 0.0381
Onchocerca volvulus 0.0169 0.2383 0.3209
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0312 0.0428
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0312 0.0428
Leishmania major hypothetical protein, conserved 0.0017 0.0099 0.0099
Onchocerca volvulus 0.0064 0.0801 0.1021
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0674 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0172 0.0677
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0034 0.036 0.0381
Brugia malayi conserved hypotetical protein 0.0015 0.0064 0.0087
Schistosoma mansoni hypothetical protein 0.0131 0.1819 0.1925
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0012 0.0019 0.0043
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.0801 0.0848
Echinococcus granulosus retinoic acid receptor rxr beta a 0.023 0.3314 0.3508
Loa Loa (eye worm) hypothetical protein 0.0043 0.0487 0.0668
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0026 0.0229 0.0903
Leishmania major phosphoglycerate kinase C, glycosomal 0.0103 0.1399 0.1399
Schistosoma mansoni amine GPCR 0.0064 0.0801 0.0848
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.0801 0.1099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0026 0.0229 0.0229
Brugia malayi Serotonin receptor 0.0064 0.0801 0.1099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0142 0.0142
Echinococcus granulosus g protein coupled receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0096
Plasmodium falciparum importin beta, putative 0.0012 0.0027 0.0106
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0172 0.0172
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0179 0.2538 1
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0591 0.1534
Giardia lamblia PHD finger protein 15 0.0033 0.0332 0.0766
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0283 0.4102 0.4341
Echinococcus multilocularis importin subunit beta 1 0.0012 0.0027 0.0029
Trichomonas vaginalis esterase, putative 0.005 0.0591 0.1534
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0312 0.0428
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.0801 0.0848
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0312 0.033
Echinococcus granulosus axis inhibition protein axin 0.0011 0.0003 0.0003
Echinococcus multilocularis glutamate receptor 2 0.0013 0.0045 0.0048
Echinococcus granulosus neuropeptide receptor 0.0064 0.0801 0.0848
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0103 0.1399 0.269
Echinococcus multilocularis axis inhibition protein axin 0.0011 0.0003 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Loa Loa (eye worm) hypothetical protein 0.005 0.0591 0.081
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0012 0.0019 0.002
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0034 0.036 0.036
Brugia malayi PXA domain containing protein 0.0011 0.0003 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0064 0.0067
Brugia malayi Glutamate receptor 1 precursor 0.0011 0.0013 0.0017
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.036 0.036
Plasmodium falciparum glutathione reductase 0.0022 0.0172 0.0677
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0159 0.0168
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.1419
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.0801 0.0848
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0034 0.036 0.0381
Brugia malayi A-kinase anchor protein 10, precursor 0.0011 0.0003 0.0004
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0064 0.0067
Loa Loa (eye worm) hypothetical protein 0.0079 0.1031 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0312 0.0428
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0003 0.0003
Loa Loa (eye worm) glutathione reductase 0.0063 0.0794 0.109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0641 0.0678
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.0801 0.0848
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0012 0.0019 0.002
Schistosoma mansoni amine GPCR 0.0064 0.0801 0.0848
Brugia malayi Glutamate receptor 2 precursor 0.0011 0.0013 0.0017
Schistosoma mansoni neuropeptide receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Loa Loa (eye worm) hypothetical protein 0.0045 0.0527 0.0723
Schistosoma mansoni amine GPCR 0.0064 0.0801 0.0848
Leishmania major DNA polymerase eta, putative 0.0036 0.0392 0.0392
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0446 0.0472
Plasmodium falciparum glutathione reductase 0.0063 0.0794 0.313
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0129 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Brugia malayi Pre-SET motif family protein 0.0233 0.3352 0.4598
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.3352 0.4598
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0096
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.0801 0.0848
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0015 0.0067 0.0071
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0064 0.0067
Schistosoma mansoni caspase-7 (C14 family) 0.0034 0.0361 0.0382
Echinococcus multilocularis beta LACTamase domain containing family member 0.005 0.0591 0.0625
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0013 0.0031 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0312 0.0428
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi Cell death protein 3 precursor 0.0034 0.0361 0.0496
Schistosoma mansoni ap endonuclease 0.0026 0.0229 0.0243
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.1399 0.1481
Brugia malayi hypothetical protein 0.0016 0.009 0.0124
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi nuclear receptor NHR-67 0.0015 0.0064 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0095 0.127 0.127
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0034 0.036 0.0381
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0006 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Brugia malayi Thioredoxin reductase 0.0063 0.0794 0.109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0312 0.033
Brugia malayi Bm-MIF-1, identical 0.0179 0.2538 0.3481
Schistosoma mansoni histamine h1 receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0103 0.1399 0.192
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0159 0.0168
Schistosoma mansoni nuclear receptor 0.0015 0.0064 0.0067
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.0801 0.1099
Schistosoma mansoni amine GPCR 0.0064 0.0801 0.0848
Schistosoma mansoni chromobox protein 0.0037 0.0398 0.0421
Echinococcus multilocularis axis inhibition protein axin 0.0011 0.0003 0.0003
Echinococcus multilocularis apoptotic protease activating factor 1 0.0034 0.0361 0.0383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Echinococcus granulosus beta-adrenergic receptor kinase 0.0103 0.1399 0.1481
Plasmodium vivax glutathione reductase, putative 0.0063 0.0794 0.313
Schistosoma mansoni hypothetical protein 0.0033 0.034 0.036
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0003 0.0003
Echinococcus granulosus flap endonuclease 1 0.0013 0.0031 0.0033
Plasmodium falciparum phd finger protein, putative 0.0033 0.0332 0.1308
Trypanosoma brucei phosphoglycerate kinase 0.0038 0.0413 0.0413
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0064 0.0087
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0034 0.036 0.0494
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0013 0.0045 0.0048
Trichomonas vaginalis ap endonuclease, putative 0.0026 0.0229 0.059
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.0801 0.0848
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.1399 0.1399
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0159 0.0299
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0312 0.0428
Echinococcus multilocularis regulator of G protein signaling 0.0011 0.0003 0.0003
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.0801 0.1099
Schistosoma mansoni ap endonuclease 0.0026 0.0229 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0794 0.109
Echinococcus multilocularis neuropeptide receptor A26 0.0064 0.0801 0.0848
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0172 0.0172
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Mycobacterium tuberculosis Probable hydrolase 0.005 0.0591 0.1131
Trypanosoma brucei DNA polymerase eta, putative 0.0036 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0013 0.0031 0.0077
Entamoeba histolytica phosphoglycerate kinase, putative 0.0103 0.1399 0.5508
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0064 0.0067
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0801 0.0848
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0197 0.281 0.3854
Mycobacterium tuberculosis Conserved protein 0.005 0.0591 0.1131
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0124
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.0801 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0312 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.036 0.0932
Loa Loa (eye worm) hypothetical protein 0.0053 0.0641 0.0879
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0312 0.0428
Echinococcus granulosus regulator of G protein signaling 3 0.0011 0.0003 0.0003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0312 0.033
Brugia malayi hypothetical protein 0.0034 0.0361 0.0496
Mycobacterium tuberculosis Probable lipase LipE 0.005 0.0591 0.1131
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.006 0.006
Echinococcus granulosus snurportin 1 0.0131 0.1819 0.1925
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.1399 0.3643
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0159 0.0218
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0003 0.0004
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0159 0.0615
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.1399 0.1399
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0312 0.033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.009 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0123 0.1703 0.1803
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0013 0.0045 0.0048
Mycobacterium ulcerans lipase LipD 0.005 0.0591 0.1131
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0159 0.0299
Brugia malayi Pre-SET motif family protein 0.0034 0.0354 0.0486
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.005 0.0591 0.0625
Echinococcus multilocularis GPCR, family 2 0.0015 0.0072 0.0077
Echinococcus multilocularis beta adrenergic receptor kinase 0.0103 0.1399 0.1481
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0524 0.0555
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0801 0.0848
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0172 0.0172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0795 0.1937
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0031 0.0121
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0172 0.0677
Brugia malayi PXA domain containing protein 0.0011 0.0003 0.0004
Schistosoma mansoni neuropeptide receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) T-complex protein 1 0.0012 0.0019 0.0027
Brugia malayi jmjC domain containing protein 0.0043 0.0494 0.0678
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.0801 0.0848
Brugia malayi steroid hormone receptor 0.0031 0.0312 0.0428
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi GnHR receptor homolog 0.0064 0.0801 0.1099
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.0794 0.0841
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1771 0.2429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0096
Schistosoma mansoni flap endonuclease-1 0.0011 0.0013 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0159 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.005 0.0591 0.1534
Entamoeba histolytica Flap nuclease, putative 0.0013 0.0031 0.0113
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0332 0.0351
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0013 0.0031 0.0031
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0494 0.0523
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis sex peptide receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.009 0.0124
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0319 0.4649 0.4649
Plasmodium falciparum phosphodiesterase delta, putative 0.0034 0.036 0.1419
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0801 0.1099
Schistosoma mansoni hypothetical protein 0.0015 0.0072 0.0077
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0312 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Echinococcus granulosus regulator of G protein signaling 3 0.0011 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Echinococcus multilocularis chromobox protein 1 0.0037 0.0398 0.0421
Brugia malayi Importin beta-1 subunit 0.0012 0.0027 0.0037
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0172 0.0441
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Trichomonas vaginalis penicillin-binding protein, putative 0.005 0.0591 0.1534
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0283 0.4102 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Echinococcus multilocularis orexin receptor type 2 0.0064 0.0801 0.0848
Loa Loa (eye worm) runx1 0.0062 0.0776 0.1065
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni hypothetical protein 0.0064 0.0801 0.0848
Giardia lamblia DINP protein human, muc B family 0.0021 0.0159 0.0342
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.0801 0.0848
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0494 0.7291 1
Echinococcus multilocularis serotonin receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis expressed protein 0.0011 0.0003 0.0003
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0159 0.0168
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.0801 0.1099
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0034 0.036 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.005 0.0591 0.081
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0172 0.0324
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0093 0.1238 0.1311
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0064 0.0087
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0354 0.0375
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0283 0.4102 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0801 0.0848
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0172 0.0324
Brugia malayi Regulator of G protein signaling domain containing protein 0.0011 0.0003 0.0004
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.005 0.0591 0.1131
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni nuclear receptor 0.0015 0.0064 0.0067
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.0801 0.0848
Schistosoma mansoni glutamate receptor kainate 0.0011 0.0013 0.0013
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0248 0.0262
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0034 0.036 0.0494
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0398 0.1031
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0319 0.4649 0.4649
Echinococcus multilocularis caspase 2 0.0034 0.0361 0.0382
Schistosoma mansoni hypothetical protein 0.0015 0.0072 0.0077
Loa Loa (eye worm) beta-lactamase 0.005 0.0591 0.081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0332 0.0455
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0034 0.036 0.036
Schistosoma mansoni opsin-like receptor 0.0064 0.0801 0.0848
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0674 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0312 0.033
Brugia malayi PHD-finger family protein 0.0015 0.0061 0.0084
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0013 0.0013
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.0413 0.0413
Echinococcus granulosus dna polymerase kappa 0.0021 0.0159 0.0168
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.0801 0.0848
Brugia malayi Regulator of G protein signaling domain containing protein 0.0011 0.0003 0.0004
Echinococcus granulosus glutamate receptor 2 0.0013 0.0045 0.0048
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.0801 0.0848
Brugia malayi G protein-coupled receptor 0.0064 0.0801 0.1099
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0794 0.313
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.0801 0.0848
Brugia malayi hypothetical protein 0.0011 0.0003 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0064 0.0067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0172 0.0172
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis snurportin 1 0.0131 0.1819 0.1925
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0084 0.0116
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.0801 0.1099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0064 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.006 0.006
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0139 0.019
Schistosoma mansoni hypothetical protein 0.0637 0.9449 1
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.036 0.036
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0076 0.0992 0.1361
Loa Loa (eye worm) hypothetical protein 0.0283 0.4102 0.5626
Mycobacterium tuberculosis Probable conserved lipoprotein 0.005 0.0591 0.1131
Trypanosoma cruzi ISWI complex protein 0.0017 0.0099 0.0099
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0159 0.0299
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0003 0.0003
Brugia malayi Phosphoglycerate kinase 0.0038 0.0413 0.0567
Loa Loa (eye worm) hypothetical protein 0.0048 0.0571 0.0783
Echinococcus granulosus neuropeptide s receptor 0.0064 0.0801 0.0848
Schistosoma mansoni neuropeptide receptor 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0084
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.0801 0.0848
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0034 0.036 0.0381
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0312 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Brugia malayi T-complex protein 1, beta subunit 0.0012 0.0019 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Onchocerca volvulus 0.005 0.0591 0.0729
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.0801 0.1099
Echinococcus granulosus serotonin receptor 0.0064 0.0801 0.0848
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0072 0.0077
Schistosoma mansoni glutamate receptor kainate 0.0011 0.0013 0.0013
Schistosoma mansoni coup transcription factor 0.0031 0.0312 0.033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Loa Loa (eye worm) hypothetical protein 0.0016 0.009 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0123 0.1703 0.1803
Leishmania major hypothetical protein, conserved 0.005 0.0591 0.0591
Onchocerca volvulus 0.0064 0.0801 0.1021
Schistosoma mansoni hypothetical protein 0.0017 0.0099 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0172 0.0374
Trypanosoma cruzi ISWI complex protein 0.0017 0.0099 0.0099
Brugia malayi hypothetical protein 0.0011 0.0003 0.0004
Schistosoma mansoni cpg binding protein 0.0031 0.0314 0.0332
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0312 0.033
Echinococcus granulosus importin subunit beta 1 0.0012 0.0027 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0064 0.0067
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.0801 0.0848
Schistosoma mansoni chromobox protein 0.0037 0.0398 0.0421
Trypanosoma brucei importin beta-1 subunit, putative 0.0012 0.0027 0.0027
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0011 0.0003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0026 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0159
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Trichomonas vaginalis chaperonin, putative 0.0012 0.0019 0.0043
Schistosoma mansoni cpg binding protein 0.0035 0.0373 0.0395
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0011 0.0007 0.0009
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.0801 0.1021
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0034 0.036 0.0494
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0142 0.0142
Onchocerca volvulus 0.0064 0.0801 0.1021
Echinococcus multilocularis regulator of G protein signaling 3 0.0011 0.0003 0.0003
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0034 0.036 0.036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.0801 0.0848
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.0801 0.0848
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0332 0.0351
Loa Loa (eye worm) hypothetical protein 0.0049 0.0586 0.0804
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.0801 0.0848
Onchocerca volvulus 0.0064 0.0801 0.1021
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0172 0.0677
Brugia malayi Bromodomain containing protein 0.0085 0.113 0.155
Giardia lamblia Flap structure-specific endonuclease 0.0013 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0064 0.0067
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0034 0.036 0.036
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0034 0.036 0.0494
Schistosoma mansoni amine GPCR 0.0064 0.0801 0.0848
Onchocerca volvulus Huntingtin homolog 0.0197 0.281 0.38
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0064 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0172 0.0172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.0801 0.0848
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.0801 0.1099
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0103 0.1399 1
Echinococcus multilocularis phosphoglycerate kinase 1 0.0103 0.1399 0.1481
Plasmodium vivax hypothetical protein, conserved 0.005 0.0591 0.2327
Echinococcus granulosus neuropeptide receptor A26 0.0064 0.0801 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0312 0.0428
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0064 0.0087
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.0801 0.0848
Loa Loa (eye worm) hypothetical protein 0.0169 0.2383 0.3269
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0172 0.0236
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0022 0.0173 0.0423
Leishmania major phosphoglycerate kinase B, cytosolic 0.0103 0.1399 0.1399
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0034 0.036 0.0381
Onchocerca volvulus 0.0064 0.0801 0.1021
Schistosoma mansoni hypothetical protein 0.0637 0.9449 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0072 0.0077
Plasmodium falciparum phosphoglycerate kinase 0.0103 0.1399 0.5513
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0034 0.036 0.0381
Mycobacterium tuberculosis Conserved protein 0.005 0.0591 0.1131
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0034 0.036 0.036
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1771 0.2429
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0034 0.036 0.036
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.0801 0.0848
Leishmania major trypanothione reductase 0.0063 0.0794 0.0794
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0013 0.0045 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Brugia malayi ecdysteroid receptor 0.0031 0.0312 0.0428
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0854 0.1172
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0801 0.0848
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0312 0.0428
Onchocerca volvulus 0.0064 0.0801 0.1021
Echinococcus granulosus expressed protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Brugia malayi hypothetical protein 0.0015 0.0064 0.0087
Brugia malayi jmjC domain containing protein 0.0107 0.1448 0.1985
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0312 0.033
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.0801 0.0848
Schistosoma mansoni hypothetical protein 0.0033 0.0332 0.0351
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0794 0.0794
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.0801 0.0848
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.0801 0.0848
Schistosoma mansoni glutamate receptor AMPA 0.0011 0.0013 0.0013
Echinococcus granulosus glutamate NMDA receptor subunit 0.0011 0.0013 0.0013
Brugia malayi hypothetical protein 0.0016 0.009 0.0124
Brugia malayi Dopamine receptor 0.0064 0.0801 0.1099
Onchocerca volvulus 0.0064 0.0801 0.1021
Schistosoma mansoni zinc finger protein 0.0015 0.0064 0.0067
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0197 0.027
Onchocerca volvulus 0.0265 0.3836 0.5219
Chlamydia trachomatis phosphoglycerate kinase 0.0103 0.1399 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0064 0.0067
Schistosoma mansoni hypothetical protein 0.0015 0.0072 0.0077
Echinococcus granulosus Regulator of G protein signaling 20 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0142 0.0195
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0332 0.081
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0312 0.033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0312 0.033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.0801 0.0848
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0159 0.0159
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Trichomonas vaginalis flap endonuclease-1, putative 0.0013 0.0031 0.0074
Echinococcus multilocularis dna polymerase eta 0.0036 0.0392 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.0801 0.0848
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.0801 0.0848
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0312 0.033
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Leishmania major hypothetical protein, conserved 0.0034 0.036 0.036
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0641 0.0678
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.0801 0.0848
Onchocerca volvulus 0.0064 0.0801 0.1021
Brugia malayi hypothetical protein 0.0494 0.7291 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0172 0.0324
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0034 0.036 0.0381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0428
Loa Loa (eye worm) hypothetical protein 0.0036 0.0392 0.0538
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0312 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0312 0.0428
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.036 0.0878
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0034 0.036 0.0932
Schistosoma mansoni hypothetical protein 0.0064 0.0801 0.0848
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.0801 0.0848
Echinococcus granulosus axis inhibition protein axin 0.0011 0.0003 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0072 0.0099
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0034 0.036 0.0932
Onchocerca volvulus 0.0064 0.0801 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.006 0.006
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0011 0.0003 0.0003
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0034 0.036 0.0381
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0129 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0355 0.5192 1
Brugia malayi putative neuropeptide receptor 0.0064 0.0801 0.1099
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.1399 0.3643
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0494 0.0678
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0026 0.0229 0.0229
Brugia malayi hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0154 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0312 0.0428
Loa Loa (eye worm) hypothetical protein 0.005 0.0591 0.081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0087
Schistosoma mansoni zinc finger protein 0.0024 0.0198 0.0209
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0142 0.0142
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0067 0.0071
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.0801 0.0848
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0026 0.0229 0.0243
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0159 0.0159
Brugia malayi exodeoxyribonuclease III family protein 0.0026 0.0229 0.0314
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1448 0.1532
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0026 0.0229 0.0514
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0494 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0312 0.0428
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0332 0.0351
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0214 0.3066 0.3245
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0034 0.036 0.0494
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Loa Loa (eye worm) hypothetical protein 0.0064 0.0801 0.1099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.004 0.0096
Schistosoma mansoni biogenic amine receptor 0.0064 0.0801 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0154 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0154 0.0393
Loa Loa (eye worm) glutamate receptor 2 0.0011 0.0013 0.0017
Plasmodium falciparum phosphodiesterase gamma, putative 0.0034 0.036 0.1419
Mycobacterium leprae conserved hypothetical protein 0.005 0.0591 0.3412
Loa Loa (eye worm) hypothetical protein 0.0034 0.0361 0.0496
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0248 0.3583 0.4915
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0524 0.0555
Onchocerca volvulus 0.005 0.0591 0.0729
Mycobacterium tuberculosis Probable esterase LipL 0.005 0.0591 0.1131
Brugia malayi PHD-finger family protein 0.003 0.0288 0.0394

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.7 uM Inhibition of HCV (Hepatitis C Virus) NS3-4A protease. ChEMBL. 14592508
Ki (binding) = 1.7 uM Inhibition of HCV (Hepatitis C Virus) NS3-4A protease. ChEMBL. 14592508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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