Detailed information for compound 250787

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 499.104 | Formula: C30H41ClNO3+
  • H donors: 1 H acceptors: 1 LogP: 9.41 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)CC(C(=O)O[NH+](C1CCCCC1)C1CCCCC1)Oc1ccc(cc1)C(C)C
  • InChi: 1S/C30H40ClNO3/c1-22(2)24-16-18-28(19-17-24)34-29(21-23-10-9-11-25(31)20-23)30(33)35-32(26-12-5-3-6-13-26)27-14-7-4-8-15-27/h9-11,16-20,22,26-27,29H,3-8,12-15,21H2,1-2H3/p+1
  • InChiKey: JOCKLYZAULAKHF-UHFFFAOYSA-O  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0577 0.0577
Echinococcus multilocularis RUN 0.006 0.0692 0.0692
Echinococcus granulosus Ankyrin 0.0091 0.1132 0.1132
Loa Loa (eye worm) tubulin alpha chain 0.0555 0.7672 0.7672
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Echinococcus multilocularis geminin 0.0177 0.2335 0.2335
Loa Loa (eye worm) RNA binding protein 0.0126 0.1618 0.1618
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1599 0.1599
Trichomonas vaginalis tubulin epsilon chain, putative 0.0171 0.2259 0.2259
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1095 0.1028
Echinococcus granulosus tubulin beta 4A class IVa 0.072 1 1
Schistosoma mansoni alpha tubulin 0.0555 0.7672 0.7672
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.031 0.031
Brugia malayi Tubulin alpha chain 0.0171 0.2259 0.2259
Echinococcus multilocularis Tubulin beta 2C chain 0.072 1 1
Leishmania major beta tubulin 0.072 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0555 0.7672 0.7672
Schistosoma mansoni loxhd1 0.006 0.0692 0.0692
Echinococcus multilocularis Tubulin alpha 1 chain 0.0555 0.7672 0.7672
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0108 0.0082
Echinococcus granulosus Tubulin beta 2C chain 0.072 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0555 0.7672 0.7672
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0223 0.2992 0.2992
Echinococcus multilocularis Tubulin alpha 1 chain 0.0555 0.7672 0.7672
Schistosoma mansoni tubulin subunit beta 0.0171 0.2259 0.2259
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.038 0.038
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0171 0.2259 0.2259
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0529 0.7309 0.7309
Plasmodium falciparum multidrug resistance protein 1 0.0033 0.031 0.031
Plasmodium falciparum tubulin epsilon chain, putative 0.0395 0.5407 0.5407
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1095 0.1071
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.5407 0.5373
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Entamoeba histolytica P-glyco protein 6, putative 0.0033 0.031 0.031
Schistosoma mansoni chromobox protein 0.0068 0.08 0.08
Giardia lamblia Delta tubulin 0.0171 0.2259 0.2174
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0075 0.0075
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0033 0.031 0.0325
Brugia malayi ABC transporter family protein 0.0052 0.0582 0.0582
Echinococcus granulosus multidrug resistance protein 1 0.0033 0.031 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0191 0.0122
Echinococcus multilocularis ATP binding cassette sub family G 0.0062 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Plasmodium falciparum MO15-related protein kinase 0.0117 0.1488 0.1488
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0089 0.1095 0.1095
Brugia malayi chromobox protein homolog 3 0.0038 0.038 0.038
Loa Loa (eye worm) tubulin alpha 2 0.0384 0.5257 0.5257
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.2259 0.2259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0089 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.1132 0.1132
Loa Loa (eye worm) tubulin beta chain 0.072 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0345 0.0345
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.031 0.031
Onchocerca volvulus 0.0529 0.7309 1
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0529 0.7309 0.7279
Plasmodium falciparum tubulin gamma chain 0.0395 0.5407 0.5407
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.1095 0.1095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0089 0.0019
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0103 0.0103
Echinococcus multilocularis tubulin alpha 1C chain 0.0555 0.7672 0.7672
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0577 0.0577
Trypanosoma brucei zeta tubulin 0.0171 0.2259 0.2239
Echinococcus granulosus tubulin gamma 1 chain 0.0395 0.5407 0.5407
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0089 0.1095 0.1095
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0108 0.0108
Echinococcus multilocularis tubulin alpha 0.0395 0.5407 0.5407
Trichomonas vaginalis tubulin epsilon chain, putative 0.0555 0.7672 0.7672
Trypanosoma brucei alpha tubulin 0.0555 0.7672 0.7666
Schistosoma mansoni survival motor neuron protein 0.005 0.055 0.055
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.1095 0.1095
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.031 0.031
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Schistosoma mansoni DNA polymerase eta 0.0019 0.0108 0.0108
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0033 0.031 0.031
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1618 0.1618
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0529 0.7309 0.7309
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0075 0.0075
Schistosoma mansoni tubulin subunit beta 0.072 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.0692 0.0692
Schistosoma mansoni hypothetical protein 0.006 0.0692 0.0692
Echinococcus granulosus netrin receptor unc 5 0.0091 0.1132 0.1132
Brugia malayi Doublecortin family protein 0.006 0.0692 0.0692
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0062 0.0714 0.0848
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0345 0.0345
Echinococcus granulosus tubulin alpha chain 0.0555 0.7672 0.7672
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0108
Schistosoma mansoni smdr2 0.0033 0.031 0.031
Schistosoma mansoni tumor necrosis factor receptor related 0.014 0.1811 0.1811
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0577 0.0577
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Loa Loa (eye worm) hypothetical protein 0.0033 0.031 0.031
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0075 0.0075
Leishmania major beta tubulin 0.072 1 1
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.1095 0.1095
Trichomonas vaginalis chromobox protein, putative 0.0068 0.08 0.08
Echinococcus multilocularis tubulin alpha chain 0.0555 0.7672 0.7672
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Brugia malayi Heterochromatin protein 1 0.0068 0.08 0.08
Giardia lamblia ABC transporter 0.0061 0.0699 0.0597
Trichomonas vaginalis tubulin, putative 0.0223 0.2992 0.2992
Brugia malayi Protein kinase domain containing protein 0.0092 0.1137 0.1137
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0033 0.031 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0191 0.0191
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Schistosoma mansoni tubulin subunit epsilon 0.0395 0.5407 0.5407
Brugia malayi Cell division protein ftsZ 0.0171 0.2259 0.2259
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0089 0.1095 0.1095
Loa Loa (eye worm) doublecortin family protein 0.006 0.0692 0.0692
Brugia malayi Death domain containing protein 0.0091 0.1132 0.1132
Leishmania major beta tubulin 0.072 1 1
Schistosoma mansoni chromobox protein 0.0068 0.08 0.08
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0075 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0091 0.1132 0.1132
Echinococcus granulosus tubulin delta chain 0.0171 0.2259 0.2259
Echinococcus multilocularis tubulin subunit beta 0.072 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0075 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0191 0.0191
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0108 0.0034
Brugia malayi tubulin alpha-2 chain 0.0555 0.7672 0.7672
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0384 0.5257 0.5257
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.031 0.031
Loa Loa (eye worm) tubulin alpha 2 0.0384 0.5257 0.5257
Schistosoma mansoni alpha tubulin 0.0555 0.7672 0.7672
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0075 0.0075
Trichomonas vaginalis tubulin, putative 0.0171 0.2259 0.2259
Trypanosoma cruzi zeta tubulin, putative 0.0171 0.2259 0.2201
Loa Loa (eye worm) tubulin beta-4 chain 0.072 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.031 0.031
Echinococcus multilocularis Tubulin beta 2C chain 0.072 1 1
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Entamoeba histolytica P-glycoprotein-2 0.0033 0.031 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Brugia malayi Tubulin alpha chain 0.0555 0.7672 0.7672
Loa Loa (eye worm) tubulin beta chain 0.0171 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0032 0.0295 0.0295
Echinococcus granulosus peroxisome assembly protein 26 0.0555 0.7672 0.7672
Loa Loa (eye worm) hypothetical protein 0.0332 0.4524 0.4524
Trypanosoma brucei beta tubulin 0.072 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0062 0.0714 0.0644
Schistosoma mansoni tubulin subunit delta 0.0171 0.2259 0.2259
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0171 0.2259 0.2259
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0075
Echinococcus granulosus tubulin subunit TubB 0.0555 0.7672 0.7672
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Loa Loa (eye worm) tubulin beta-2A chain 0.072 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.031 0.031
Schistosoma mansoni ankyrin 23/unc44 0.0091 0.1132 0.1132
Trypanosoma brucei unspecified product 0.0019 0.0108 0.0082
Loa Loa (eye worm) alpha-tubulin 0.0555 0.7672 0.7672
Mycobacterium tuberculosis Cell division protein FtsZ 0.0171 0.2259 0.302
Plasmodium falciparum alpha tubulin 2 0.0555 0.7672 0.7672
Trichomonas vaginalis tubulin alpha chain, putative 0.072 1 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0033 0.031 0.031
Onchocerca volvulus 0.006 0.0692 0.0947
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0108 0.0108
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0108 0.0108
Brugia malayi alpha-tubulin 0.0555 0.7672 0.7672
Brugia malayi Tubulin beta chain 0.0223 0.2992 0.2992
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.042 0.0575
Leishmania major beta tubulin 0.072 1 1
Echinococcus granulosus chromobox protein 1 0.0068 0.08 0.08
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1095 0.1028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0529 0.7309 0.7309
Loa Loa (eye worm) TAR-binding protein 0.0126 0.1618 0.1618
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0075
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0108 0.0082
Trichomonas vaginalis tubulin epsilon chain, putative 0.072 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0223 0.0223
Echinococcus granulosus tar DNA binding protein 0.0126 0.1618 0.1618
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0075 0.0075
Brugia malayi Tubulin gamma chain 0.0395 0.5407 0.5407
Trypanosoma brucei tubulin gamma chain 0.0395 0.5407 0.5395
Onchocerca volvulus 0.0033 0.031 0.0424
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0172 0.0172
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.031 0.031
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0529 0.7309 1
Toxoplasma gondii beta-tubulin, putative 0.072 1 1
Entamoeba histolytica ABC transporter, putative 0.0062 0.0714 0.0714
Trypanosoma cruzi tubulin gamma chain 0.0395 0.5407 0.5373
Echinococcus multilocularis Tubulin beta 2C chain 0.072 1 1
Leishmania major beta tubulin 0.072 1 1
Echinococcus multilocularis tubulin subunit TubB 0.0555 0.7672 0.7672
Brugia malayi isocitrate dehydrogenase 0.0016 0.0075 0.0075
Trichomonas vaginalis tubulin beta chain, putative 0.0555 0.7672 0.7672
Entamoeba histolytica P-glycoprotein-2 0.0033 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0091 0.1132 0.1132
Echinococcus granulosus tubulin alpha 3 chain 0.0555 0.7672 0.7672
Trichomonas vaginalis tubulin beta chain, putative 0.0223 0.2992 0.2992
Echinococcus multilocularis netrin receptor unc 5 0.0091 0.1132 0.1132
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0171 0.2259 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.072 1 1
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.014 0.1811 0.1811
Leishmania major beta tubulin 0.072 1 1
Giardia lamblia Beta tubulin 0.072 1 1
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.014 0.1811 0.1811
Schistosoma mansoni tubulin subunit beta 0.072 1 1
Giardia lamblia Gamma tubulin 0.0395 0.5407 0.5357
Giardia lamblia Beta tubulin 0.072 1 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0108 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0191 0.0122
Trichomonas vaginalis ABC transporter, putative 0.0033 0.031 0.031
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.031 0.031
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0108 0.0108
Entamoeba histolytica tubulin alpha chain, putative 0.0555 0.7672 0.7672
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.031 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Loa Loa (eye worm) ABC transporter 0.0052 0.0582 0.0582
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0075 0.0049
Brugia malayi Tubulin alpha-2 chain 0.0555 0.7672 0.7672
Echinococcus multilocularis chromobox protein 1 0.0068 0.08 0.08
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.3307 0.3307
Echinococcus multilocularis Ankyrin 0.0091 0.1132 0.1132
Plasmodium vivax tubulin gamma chain, putative 0.0395 0.5407 0.5407
Trichomonas vaginalis tubulin beta chain, putative 0.0555 0.7672 0.7672
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.031 0.031
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0692 0.0692
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.031 0.031
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0089 0.1095 0.1095
Trichomonas vaginalis abcb9, putative 0.0033 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0051 0.0567 0.0567
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Onchocerca volvulus 0.0025 0.0191 0.0261
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Entamoeba histolytica P-glycoprotein 5, putative 0.0033 0.031 0.031
Entamoeba histolytica tubulin family protein 0.072 1 1
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0089 0.1095 0.1095
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.031 0.031
Trichomonas vaginalis tubulin, putative 0.072 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0555 0.7672 0.7672
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0191 0.016
Echinococcus multilocularis Tubulin alpha 1 chain 0.0555 0.7672 0.7672
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0171 0.2259 0.2259
Echinococcus granulosus geminin 0.0177 0.2335 0.2335
Brugia malayi multidrug resistance protein 3 0.0033 0.031 0.031
Echinococcus granulosus tubulin alpha 3 chain 0.0555 0.7672 0.7672
Plasmodium falciparum tubulin delta chain, putative 0.0171 0.2259 0.2259
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0075 0.0075
Leishmania major epsilon tubulin, putative 0.0395 0.5407 0.5373
Toxoplasma gondii beta-1 tubulin, putative 0.072 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0555 0.7672 0.7672
Loa Loa (eye worm) hypothetical protein 0.0246 0.3307 0.3307
Echinococcus multilocularis GPCR, family 2 0.0016 0.0075 0.0075
Echinococcus multilocularis hypothetical protein 0.0555 0.7672 0.7672
Trypanosoma cruzi epsilon tubulin, putative 0.0395 0.5407 0.5373
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.0692 0.0692
Echinococcus multilocularis tubulin alpha chain 0.0555 0.7672 0.7672
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Loa Loa (eye worm) hypothetical protein 0.0052 0.0577 0.0577
Loa Loa (eye worm) tubulin alpha-3 chain 0.0332 0.4524 0.4524
Echinococcus multilocularis dna polymerase eta 0.0019 0.0108 0.0108
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0075 0.0075
Schistosoma mansoni tubulin subunit beta 0.072 1 1
Leishmania major fructose-1,6-bisphosphate aldolase 0.0089 0.1095 0.1028
Giardia lamblia Alpha-tubulin 0.0555 0.7672 0.7647
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.0034
Trichomonas vaginalis ABC transporter, putative 0.0033 0.031 0.031
Trypanosoma cruzi tubulin delta chain 0.0171 0.2259 0.2201
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0117 0.1488 0.1488
Echinococcus multilocularis peroxisome assembly protein 26 0.0555 0.7672 0.7672
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0223 0.0223
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0075 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0191 0.016
Echinococcus multilocularis chromobox protein 1 0.0068 0.08 0.08
Echinococcus granulosus multidrug resistance protein 1 0.0033 0.031 0.031
Leishmania major gamma-tubulin 0.0395 0.5407 0.5373
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0091 0.1132 0.1132
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1618 0.1618
Schistosoma mansoni tubulin subunit alpha 0.0555 0.7672 0.7672
Trichomonas vaginalis tubulin beta chain, putative 0.072 1 1
Trichomonas vaginalis taga, putative 0.0033 0.031 0.031
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.2259 0.2259
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.036 0.4922 0.4922
Treponema pallidum cell division protein FtsZ 0.0171 0.2259 0.5
Schistosoma mansoni hypothetical protein 0.0177 0.2335 0.2335
Brugia malayi fructose-bisphosphate aldolase 1 0.0089 0.1095 0.1095
Trichomonas vaginalis tubulin epsilon chain, putative 0.0555 0.7672 0.7672
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0062 0.0714 0.0848
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0529 0.7309 0.7309
Leishmania major beta tubulin 0.072 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0033 0.031 0.031
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0033 0.031 0.0237
Echinococcus multilocularis tubulin gamma 1 chain 0.0395 0.5407 0.5407
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0191 0.0117
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0108 0.0108
Echinococcus granulosus tubulin epsilon chain 0.0395 0.5407 0.5407
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0075 0.0075
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0051 0.0567 0.0681
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.031 0.031
Brugia malayi N-terminal motif family protein 0.0183 0.2423 0.2423
Trichomonas vaginalis abcb9, putative 0.0033 0.031 0.031
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Entamoeba histolytica tubulin gamma chain 0.0395 0.5407 0.5407
Loa Loa (eye worm) tubulin gamma chain 0.0395 0.5407 0.5407
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0075
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1095 0.1028
Leishmania major beta tubulin 0.072 1 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0191 0.0122
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.031 0.031
Trypanosoma brucei ATP-binding cassette protein, putative 0.0062 0.0714 0.069
Echinococcus multilocularis ATP binding cassette sub family G 0.0062 0.0714 0.0714
Onchocerca volvulus 0.005 0.055 0.0752
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0395 0.5407 0.5407
Loa Loa (eye worm) hypothetical protein 0.003 0.0264 0.0264
Entamoeba histolytica P-glycoprotein-1 0.0033 0.031 0.031
Echinococcus granulosus tubulin alpha 0.0395 0.5407 0.5407
Toxoplasma gondii alpha-tubulin I, putative 0.0555 0.7672 0.7672
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0108 0.0108
Plasmodium falciparum LCCL domain-containing protein 0.006 0.0692 0.0692
Echinococcus granulosus RUN 0.006 0.0692 0.0692
Echinococcus granulosus Tubulin alpha 1 chain 0.0555 0.7672 0.7672
Plasmodium vivax ABC transporter G family member 2, putative 0.0062 0.0714 0.0714
Trypanosoma brucei epsilon tubulin 0.0395 0.5407 0.5395
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.1095 0.1095
Loa Loa (eye worm) tubulin beta-1 chain 0.072 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0555 0.7672 0.7672
Loa Loa (eye worm) tubulin alpha-2 chain 0.0555 0.7672 0.7672
Echinococcus granulosus tubulin alpha 1C chain 0.0555 0.7672 0.7672
Leishmania major p-glycoprotein 0.0033 0.031 0.0237
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0529 0.7309 0.7309
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Echinococcus multilocularis tubulin delta chain 0.0171 0.2259 0.2259
Brugia malayi Uncoordinated protein 44 0.0091 0.1132 0.1132
Echinococcus granulosus chromobox protein 1 0.0068 0.08 0.08
Echinococcus granulosus microtubule associated protein 2 0.0717 0.9952 0.9952
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.1095 0.1095
Leishmania major beta tubulin 0.072 1 1
Brugia malayi Tubulin beta chain 0.0171 0.2259 0.2259
Toxoplasma gondii alpha tubulin TUBA1 0.0555 0.7672 0.7672
Trichomonas vaginalis tubulin epsilon chain, putative 0.072 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.9952 0.9952
Echinococcus granulosus death domain containing protein 0.0091 0.1132 0.1132
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0089 0.1095 0.1095
Echinococcus granulosus tubulin alpha chain 0.0555 0.7672 0.7672
Echinococcus multilocularis tubulin alpha chain 0.0555 0.7672 0.7672
Onchocerca volvulus Netrin receptor homolog 0.0091 0.1132 0.1549
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0108 0.0108
Giardia lamblia Alpha-tubulin 0.0555 0.7672 0.7647
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Schistosoma mansoni tubulin subunit alpha 0.0171 0.2259 0.2259
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0529 0.7309 0.7309
Echinococcus granulosus tubulin alpha chain 0.0555 0.7672 0.7672
Trypanosoma brucei epsilon tubulin 0.0395 0.5407 0.5395
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0108 0.0108
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0109 0.1379 0.1379
Trypanosoma brucei epsilon tubulin 0.0395 0.5407 0.5395
Loa Loa (eye worm) hypothetical protein 0.0183 0.2423 0.2423
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.2423 0.3315
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0108 0.0046
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0191 0.0122
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Echinococcus multilocularis Tubulin beta 2C chain 0.072 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0191 0.0191
Echinococcus granulosus ATP binding cassette sub family G 0.0062 0.0714 0.0714
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0033 0.031 0.031
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.0692 0.0692
Trichomonas vaginalis tubulin, putative 0.0223 0.2992 0.2992
Entamoeba histolytica P-glycoprotein-5 0.0033 0.031 0.031
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0191 0.0191
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.031 0.031
Echinococcus granulosus tubulin alpha chain 0.0555 0.7672 0.7672
Leishmania major beta tubulin 0.072 1 1
Mycobacterium leprae cell division protein FtsZ 0.0171 0.2259 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0091 0.1132 0.1132
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0191 0.0117
Schistosoma mansoni tubulin subunit alpha 0.0555 0.7672 0.7672
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0172 0.0172
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0191 0.0122
Loa Loa (eye worm) hypothetical protein 0.006 0.0692 0.0692
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0529 0.7309 0.7309
Echinococcus multilocularis ATP binding cassette sub family G 0.0062 0.0714 0.0714
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.055 0.055
Brugia malayi ABC transporter family protein 0.0033 0.031 0.031
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0108 0.0082
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0529 0.7309 0.7309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.0034
Echinococcus granulosus beta tubulin 0.072 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0555 0.7672 0.7672
Giardia lamblia Beta tubulin 0.072 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0033 0.031 0.031
Schistosoma mansoni tubulin subunit beta 0.072 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0032 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0038 0.038 0.038
Echinococcus multilocularis tubulin, beta 4A class IVa 0.072 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0555 0.7672 0.7672
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0089 0.1095 0.1095
Trypanosoma cruzi ABC transporter, putative 0.0062 0.0714 0.0644
Echinococcus granulosus GPCR family 2 0.0016 0.0075 0.0075
Echinococcus multilocularis multidrug resistance protein 1 0.0033 0.031 0.031
Trypanosoma brucei alpha tubulin 0.0555 0.7672 0.7666
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0108 0.0034
Leishmania major beta tubulin 0.072 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.072 1 1
Onchocerca volvulus 0.0223 0.2992 0.4093
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0033 0.031 0.031
Schistosoma mansoni multidrug resistance protein 0.0033 0.031 0.031
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0062 0.0714 0.0848
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Brugia malayi fructose-bisphosphate aldolase 2 0.0089 0.1095 0.1095
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0191 0.0122
Echinococcus multilocularis multidrug resistance protein 1 0.0033 0.031 0.031
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0091 0.1132 0.1132
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0103 0.0039
Schistosoma mansoni rab6-interacting 0.006 0.0692 0.0692
Echinococcus multilocularis tubulin beta 1 chain 0.072 1 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0032 0.0295 0.0295
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0062 0.0714 0.0644
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1599 0.1599
Trichomonas vaginalis tubulin beta chain, putative 0.0555 0.7672 0.7672
Trichomonas vaginalis abcb9, putative 0.0033 0.031 0.031
Trypanosoma brucei beta tubulin 0.072 1 1
Loa Loa (eye worm) alpha-tubulin 0.0555 0.7672 0.7672
Loa Loa (eye worm) BEN-1 protein 0.072 1 1
Echinococcus multilocularis tar DNA binding protein 0.0126 0.1618 0.1618
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0529 0.7309 1
Echinococcus granulosus tubulin beta 1 chain 0.072 1 1
Trypanosoma brucei beta tubulin 0.072 1 1
Schistosoma mansoni tubulin subunit beta 0.072 1 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1618 0.1618
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1618 0.1618
Loa Loa (eye worm) hypothetical protein 0.0555 0.7672 0.7672
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0172 0.0172
Schistosoma mansoni ABC transporter 0.0052 0.0582 0.0582
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0191 0.0191
Onchocerca volvulus 0.003 0.0264 0.0361
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0384 0.5257 0.5257
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0191 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Leishmania major beta tubulin 0.072 1 1
Schistosoma mansoni multidrug resistance protein 0.0033 0.031 0.031
Trichomonas vaginalis tubulin gamma chain, putative 0.0395 0.5407 0.5407
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0089 0.1095 0.1095
Echinococcus granulosus tubulin alpha 1C chain 0.0555 0.7672 0.7672
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0075 0.0075
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.2992 0.2992
Trichomonas vaginalis chromobox protein, putative 0.0041 0.042 0.042
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0033 0.031 0.031
Brugia malayi Tubulin alpha-2 chain 0.0555 0.7672 0.7672
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0384 0.5257 0.5257
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0062 0.0714 0.0714
Leishmania major zeta tubulin, putative 0.0171 0.2259 0.2201
Loa Loa (eye worm) BEN-1 protein 0.072 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0108 0.0008
Toxoplasma gondii beta tubulin 0.072 1 1
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0062 0.0714 0.0714
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.031 0.031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.0034
Loa Loa (eye worm) multidrug resistance protein 3 0.0033 0.031 0.031
Trichomonas vaginalis chromobox protein, putative 0.0041 0.042 0.042
Schistosoma mansoni tubulin subunit gamma 0.0395 0.5407 0.5407
Trichomonas vaginalis chromobox protein, putative 0.0068 0.08 0.08
Brugia malayi hypothetical protein 0.0246 0.3307 0.3307
Entamoeba histolytica tubulin family protein 0.072 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.2992 0.2992
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.038 0.038
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0172 0.0172
Brugia malayi MH2 domain containing protein 0.0125 0.1599 0.1599
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.014 0.1811 0.1811
Trypanosoma cruzi tubulin delta chain 0.0171 0.2259 0.2201
Echinococcus granulosus ATP binding cassette sub family G 0.0062 0.0714 0.0714
Echinococcus granulosus tubulin subunit beta 0.072 1 1
Leishmania major beta tubulin 0.072 1 1
Schistosoma mansoni tubulin subunit beta 0.072 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Schistosoma mansoni hypothetical protein 0.0036 0.0345 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Brugia malayi tubulin alpha chain - mouse 0.0555 0.7672 0.7672
Leishmania major alpha tubulin 0.0555 0.7672 0.7655
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.1095 0.1095
Trypanosoma brucei ABC transporter, putative 0.0062 0.0714 0.069
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0089 0.1095 0.1095
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0075 0.0075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.1618 0.1618
Trypanosoma brucei tubulin delta chain 0.0171 0.2259 0.2239
Schistosoma mansoni multidrug resistance protein 0.0033 0.031 0.031
Entamoeba histolytica tubulin alpha-1 chain 0.0555 0.7672 0.7672
Brugia malayi beta-tubulin, identical 0.072 1 1
Leishmania major delta tubulin, putative 0.0171 0.2259 0.2201
Plasmodium falciparum tubulin beta chain 0.072 1 1
Trichomonas vaginalis ABC transporter, putative 0.0033 0.031 0.031
Leishmania major beta tubulin 0.072 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Brugia malayi hypothetical protein 0.006 0.0692 0.0692
Schistosoma mansoni rab6-interacting 0.006 0.0692 0.0692
Loa Loa (eye worm) tubulin alpha 2 0.0161 0.2108 0.2108
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1618 0.1618
Onchocerca volvulus 0.006 0.0692 0.0947
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.08 0.08
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1095 0.1028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0108 0.0108
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0108 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0191 0.0191
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0108 0.0082
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0108 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0191 0.0117
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.2992 0.2992
Brugia malayi RNA binding protein 0.0126 0.1618 0.1618
Trichomonas vaginalis tubulin alpha chain, putative 0.0395 0.5407 0.5407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0089 0.0019
Echinococcus granulosus ATP binding cassette sub family G 0.0062 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.006 0.0692 0.0692
Echinococcus multilocularis beta tubulin 0.072 1 1
Schistosoma mansoni polycystin 1-related 0.006 0.0692 0.0692
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0075 0.0075
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0075 0.0049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0191 0.0191
Trypanosoma brucei alpha tubulin 0.0555 0.7672 0.7666
Plasmodium vivax tubulin alpha chain, putative 0.0555 0.7672 0.7672
Plasmodium vivax tubulin alpha chain, putative 0.0555 0.7672 0.7672
Echinococcus granulosus alpha tubulin 0.0555 0.7672 0.7672
Trypanosoma cruzi beta tubulin, putative 0.072 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.038 0.052
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0089 0.1095 0.1095
Leishmania major DNA polymerase kappa, putative 0.0019 0.0108 0.0034
Leishmania major beta tubulin 0.072 1 1
Schistosoma mansoni lipoxygenase 0.0252 0.3394 0.3394
Echinococcus granulosus multidrug resistance protein 1 0.0033 0.031 0.031
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Echinococcus multilocularis tubulin alpha chain 0.0555 0.7672 0.7672
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.014 0.1811 0.1811
Trichomonas vaginalis tubulin gamma chain, putative 0.0171 0.2259 0.2259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0089 0.0019
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0033 0.031 0.031
Loa Loa (eye worm) beta-tubulin 0.072 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0692 0.0692
Schistosoma mansoni alpha tubulin 0.0555 0.7672 0.7672
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0692 0.0692
Trypanosoma brucei alpha tubulin, putative 0.0223 0.2992 0.2973
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0091 0.1132 0.1132
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0692 0.0692
Leishmania major DNA polymerase eta, putative 0.0019 0.0108 0.0034
Echinococcus multilocularis Tubulin beta 2C chain 0.072 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.9952 0.9952
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.031 0.031
Trypanosoma brucei beta tubulin 0.0395 0.5407 0.5395
Schistosoma mansoni hypothetical protein 0.005 0.055 0.055
Plasmodium falciparum ABC transporter G family member 2 0.0062 0.0714 0.0714
Plasmodium vivax tubulin beta chain, putative 0.072 1 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0108 0.0108
Echinococcus granulosus Tubulin beta 2C chain 0.072 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.3307 0.3307
Plasmodium vivax delta tubulin, putative 0.0171 0.2259 0.2259
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.0034
Echinococcus granulosus beta tubulin 0.072 1 1
Schistosoma mansoni netrin receptor unc5 0.0091 0.1132 0.1132
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0191 0.0122
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.031 0.031
Trypanosoma brucei alpha tubulin 0.0555 0.7672 0.7666
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0082
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0332 0.4524 0.4524
Trypanosoma cruzi zeta tubulin, putative 0.0171 0.2259 0.2201
Mycobacterium ulcerans cell division protein FtsZ 0.0171 0.2259 0.2993
Entamoeba histolytica P-glycoprotein-2, putative 0.0033 0.031 0.031
Echinococcus multilocularis tubulin epsilon chain 0.0395 0.5407 0.5407
Leishmania major beta tubulin 0.072 1 1
Trypanosoma brucei beta tubulin 0.072 1 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.1132 0.1132
Echinococcus granulosus tubulin alpha chain 0.0555 0.7672 0.7672
Trichomonas vaginalis tubulin gamma chain, putative 0.072 1 1
Trypanosoma brucei zeta tubulin, putative 0.0171 0.2259 0.2239
Schistosoma mansoni lipoxygenase 0.036 0.4922 0.4922
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0529 0.7309 0.7309
Giardia lamblia Epsilon tubulin 0.0171 0.2259 0.2174
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0062 0.0714 0.0644
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0033 0.031 0.031
Echinococcus multilocularis tubulin alpha 3 chain 0.0555 0.7672 0.7672
Plasmodium vivax tubulin epsilon chain, putative 0.0395 0.5407 0.5407
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0191 0.0122
Plasmodium falciparum alpha tubulin 1 0.0555 0.7672 0.7672
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0108 0.0008
Echinococcus granulosus arachidonate 5 lipoxygenase 0.036 0.4922 0.4922
Schistosoma mansoni hypothetical protein 0.0177 0.2335 0.2335
Leishmania major beta tubulin 0.072 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.1618 0.1618
Trichomonas vaginalis ABC transporter, putative 0.0033 0.031 0.031
Brugia malayi TAR-binding protein 0.0126 0.1618 0.1618
Trichomonas vaginalis tubulin gamma chain, putative 0.0395 0.5407 0.5407
Trichomonas vaginalis tubulin beta chain, putative 0.0555 0.7672 0.7672
Echinococcus granulosus Tubulin beta 2C chain 0.072 1 1
Echinococcus multilocularis tubulin alpha chain 0.0555 0.7672 0.7672
Brugia malayi hypothetical protein 0.006 0.0692 0.0692
Plasmodium falciparum fructose-bisphosphate aldolase 0.0089 0.1095 0.1095
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0033 0.031 0.031
Schistosoma mansoni tubulin subunit alpha 0.0555 0.7672 0.7672
Leishmania major beta tubulin 0.072 1 1
Echinococcus multilocularis beta tubulin 0.072 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0555 0.7672 0.7655
Trichomonas vaginalis tubulin beta chain, putative 0.0555 0.7672 0.7672
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0103 0.0103
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0529 0.7309 0.7309

Activities

Activity type Activity value Assay description Source Reference
Basal uptake (functional) = 160 % compound was evaluated for their acute effects in vitro by measuring 2-Deoxyglucose (2DG) uptake in vehicle treated 3T3-L1 adipocytes at 100 uM dose. ChEMBL. 8941393
ED50 (functional) > 50 mg kg-1 Compound was tested for inhibition of gluconeogenesis ChEMBL. 8941393
Hypoglycemic activity (functional) = 32 % compound was tested in vivo for hypoglycemic activity in 6-8 week old C57BL/6J ob/ob mouse at 50 mg/kg ChEMBL. 8941393

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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