TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.437 | Formula: C22H23N3O2
H donors: 0 H acceptors: 2 LogP: 4.26 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCOc1cccc(c1)/C=C(/c1noc2c1cccc2)\C#N)CC
InChi: 1S/C22H23N3O2/c1-3-25(4-2)12-13-26-19-9-7-8-17(15-19)14-18(16-23)22-20-10-5-6-11-21(20)27-24-22/h5-11,14-15H,3-4,12-13H2,1-2H3/b18-14+
InChiKey: JYHDNEUNQXUQPR-NBVRZTHBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0258	0.0719	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Trypanosoma cruzi	hypothetical protein	0.0066	0.0086	0.4668
Echinococcus granulosus	axis inhibition protein axin	0.0398	0.1181	0.118
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0066	0.0086	0.0718
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3072	1	1
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0066	0.0086	0.0085
Echinococcus multilocularis	Pleckstrin y	0.0066	0.0086	0.0086
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0066	0.0086	0.0086
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0398	0.1181	0.118
Schistosoma mansoni	growth factor receptor-bound protein	0.0066	0.0086	0.0085
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0076	0.0118	0.6407
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0066	0.0086	0.0718
Loa Loa (eye worm)	PH domain-containing protein	0.0066	0.0086	0.0085
Schistosoma mansoni	hypothetical protein	0.0066	0.0086	0.0085
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0076	0.0118	1
Echinococcus multilocularis	Pleckstrin y	0.0066	0.0086	0.0086
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0816	0.256	0.2558
Trichomonas vaginalis	kinesin light chain, putative	0.0066	0.0086	0.0718
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1214	0.3872	0.3871
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0066	0.0086	0.0085
Onchocerca volvulus		0.0066	0.0086	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0187	0.0185
Schistosoma mansoni	vav2	0.0066	0.0086	0.0085
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0398	0.1181	0.3047
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0076	0.0118	0.0288
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0398	0.1181	0.118
Echinococcus multilocularis	oxysterol binding protein 3	0.0066	0.0086	0.0086
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0095	0.0183	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Entamoeba histolytica	hypothetical protein	0.0398	0.1181	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0076	0.0118	1
Brugia malayi	Dynamin	0.0066	0.0086	0.0219
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0066	0.0086	0.0085
Echinococcus multilocularis	regulator of G protein signaling	0.0398	0.1181	0.1181
Loa Loa (eye worm)	hypothetical protein	0.0398	0.1181	0.118
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0066	0.0086	0.0085
Echinococcus granulosus	oxysterol binding protein 9	0.0066	0.0086	0.0085
Brugia malayi	Protein kinase domain containing protein	0.0076	0.0118	0.03
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0066	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0398	0.1181	0.118
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0095	0.0183	1
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0066	0.0086	0.4668
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0066	0.0086	0.0219
Echinococcus granulosus	oxysterol binding protein 3	0.0066	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Loa Loa (eye worm)	rho-GTPase-activating	0.0066	0.0086	0.0085
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.0187	0.0478
Schistosoma mansoni	oxysterol-binding protein 1	0.0066	0.0086	0.0085
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0187	0.0185
Trypanosoma cruzi	PH domain containing protein, putative	0.0066	0.0086	0.4668
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Trypanosoma cruzi	PH domain containing protein, putative	0.0066	0.0086	0.4668
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3072	1	1
Schistosoma mansoni	regulator of G protein signaling	0.0398	0.1181	0.118
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0066	0.0086	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0398	0.1181	0.118
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0066	0.0086	0.0086
Toxoplasma gondii	AtPH1 family protein	0.0066	0.0086	0.1834
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0066	0.0086	0.1834
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0066	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0066	0.0086	0.0718
Schistosoma mansoni	regulator of G protein signaling	0.0398	0.1181	0.118
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0398	0.1181	0.118
Loa Loa (eye worm)	oxysterol binding protein	0.0066	0.0086	0.0085
Plasmodium vivax	PH domain containing protein	0.0066	0.0086	0.7285
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0066	0.0086	0.0718
Echinococcus multilocularis	regulator of G protein signaling 7	0.0398	0.1181	0.1181
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0066	0.0086	0.4668
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0816	0.256	0.256
Entamoeba histolytica	hypothetical protein	0.0398	0.1181	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0066	0.0086	0.0085
Schistosoma mansoni	regulator of G protein signaling	0.0398	0.1181	0.118
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0066	0.0086	0.0085
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0187	0.0185
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0187	0.0187
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Echinococcus multilocularis	regulator of G protein signaling 7	0.0398	0.1181	0.1181
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.0086	0.0219
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0066	0.0086	0.0085
Brugia malayi	MAX-1A	0.0066	0.0086	0.0219
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0066	0.0086	0.0718
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0095	0.0183	1
Brugia malayi	Syntrophin-1	0.0066	0.0086	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Trypanosoma cruzi	hypothetical protein	0.0066	0.0086	0.4668
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0066	0.0086	0.0718
Schistosoma mansoni	regulator of G protein signaling	0.0398	0.1181	0.118
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0002	0.5
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0174	0.0441	0.0441
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0068	0.0094	0.0093
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Echinococcus granulosus	WGR domain containing protein	0.0054	0.0046	0.0045
Entamoeba histolytica	hypothetical protein	0.0398	0.1181	1
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0054	0.0046	0.0045
Schistosoma mansoni	serine/threonine protein kinase	0.3072	1	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Trypanosoma cruzi	NIMA-related kinase, putative	0.0076	0.0118	0.6407
Schistosoma mansoni	centaurin alpha	0.0066	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Echinococcus multilocularis	Pleckstrin y	0.0066	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0066	0.0086	0.0086
Entamoeba histolytica	protein kinase, putative	0.0076	0.0118	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0082	0.0141	0.0139
Brugia malayi	regulator of G-protein signaling rgs-7	0.0398	0.1181	0.3047
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0066	0.0086	0.0086
Entamoeba histolytica	hypothetical protein	0.0076	0.0118	0.0288
Onchocerca volvulus		0.0066	0.0086	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0076	0.0118	0.0986
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Schistosoma mansoni	zinc finger protein	0.0066	0.0086	0.0085
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0066	0.0086	0.4668
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0066	0.0086	0.0086
Echinococcus granulosus	Pleckstrin y	0.0066	0.0086	0.0085
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0066	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Brugia malayi	Plekhf2 protein	0.0066	0.0086	0.0219
Loa Loa (eye worm)	cytohesin 3	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.1181	1
Entamoeba histolytica	protein kinase, putative	0.0076	0.0118	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Echinococcus granulosus	dynamin 1	0.0066	0.0086	0.0085
Echinococcus multilocularis	cytohesin 1	0.0066	0.0086	0.0086
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0066	0.0086	0.0086
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1214	0.3872	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0398	0.1181	0.118
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.0187	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Echinococcus granulosus	oxysterol binding protein 1	0.0066	0.0086	0.0085
Trypanosoma brucei	PH domain containing protein, putative	0.0066	0.0086	0.4668
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Schistosoma mansoni	serine/threonine-protein kinase	0.0076	0.0118	0.0116
Trichomonas vaginalis	alpha chimerin, putative	0.0066	0.0086	0.0718
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0076	0.0118	0.6407
Leishmania major	protein kinase, putative	0.0076	0.0118	1
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0066	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.1181	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0076	0.0118	0.6407
Trichomonas vaginalis	centaurin alpha, putative	0.0066	0.0086	0.0718
Echinococcus multilocularis	regulator of G protein signaling 3	0.0398	0.1181	0.1181
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0066	0.0086	0.0085
Onchocerca volvulus		0.0066	0.0086	1
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0066	0.0086	1
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0066	0.0086	0.0085
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0066	0.0086	0.0086
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Schistosoma mansoni	goodpasture antigen-binding protein	0.0066	0.0086	0.0085
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0187	0.0185
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0398	0.1181	0.1181
Onchocerca volvulus		0.0066	0.0086	1
Echinococcus granulosus	Regulator of G protein signaling 20	0.0398	0.1181	0.118
Loa Loa (eye worm)	hypothetical protein	0.0398	0.1181	0.118
Entamoeba histolytica	hypothetical protein	0.0076	0.0118	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Leishmania major	folate/biopterin transporter, putative	0.0076	0.0118	1
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0174	0.0441	0.0439
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0304	0.0303
Brugia malayi	PXA domain containing protein	0.0398	0.1181	0.3047
Schistosoma mansoni	serine/threonine protein kinase	0.1214	0.3872	0.3871
Schistosoma mansoni	serine/threonine-protein kinase	0.0076	0.0118	0.0116
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0095	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Echinococcus granulosus	pdz domain containing protein	0.0066	0.0086	0.0085
Echinococcus granulosus	expressed protein	0.0398	0.1181	0.118
Echinococcus granulosus	serine/threonine protein kinase	0.0076	0.0118	0.0116
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.1181	1
Brugia malayi	Oxysterol-binding protein	0.0066	0.0086	0.0219
Trichomonas vaginalis	centaurin beta, putative	0.0066	0.0086	0.0718
Brugia malayi	Dynamin	0.0066	0.0086	0.0219
Entamoeba histolytica	protein kinase, putative	0.0076	0.0118	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Echinococcus granulosus	Pleckstrin y	0.0066	0.0086	0.0085
Echinococcus granulosus	axis inhibition protein axin	0.0398	0.1181	0.118
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0066	0.0086	0.0086
Echinococcus granulosus	Oxysterol binding protein 11	0.0066	0.0086	0.0085
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0076	0.0118	0.6407
Schistosoma mansoni	dynamin	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0076	0.0118	0.6407
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Echinococcus granulosus	poly adp ribose polymerase 2	0.0095	0.0183	0.0181
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.018	0.0463	1
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0398	0.1181	0.118
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trypanosoma cruzi	PH domain containing protein, putative	0.0066	0.0086	0.4668
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0086	0.7285
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.1181	1
Echinococcus multilocularis	muscleblind protein	0.0169	0.0427	0.0427
Leishmania major	hypothetical protein, conserved	0.0066	0.0086	0.7285
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0066	0.0086	0.0086
Mycobacterium ulcerans	beta-lactamase	0.004	0.0002	0.5
Echinococcus multilocularis	rac serine:threonine kinase	0.0076	0.0118	0.0118
Loa Loa (eye worm)	PXA domain-containing protein	0.0398	0.1181	0.118
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0816	0.256	0.6609
Schistosoma mansoni	regulator of G protein signaling	0.0398	0.1181	0.118
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0174	0.0441	0.0439
Brugia malayi	Cytohesin 3	0.0066	0.0086	0.0219
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0174	0.0441	0.324
Onchocerca volvulus	Putative zinc finger protein	0.0066	0.0086	1
Echinococcus granulosus	cytohesin 1	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Echinococcus granulosus	regulator of G protein signaling 7	0.0398	0.1181	0.118
Toxoplasma gondii	Oxysterol-binding protein	0.0066	0.0086	0.1834
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0076	0.0118	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0427	0.0425
Onchocerca volvulus		0.0066	0.0086	1
Trypanosoma brucei	protein kinase, putative	0.0076	0.0118	0.6407
Echinococcus granulosus	muscleblind protein	0.0169	0.0427	0.0425
Echinococcus granulosus	regulator of G protein signaling 3	0.0398	0.1181	0.118
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0066	0.0086	0.7285
Echinococcus multilocularis	muscleblind protein 1	0.0169	0.0427	0.0427
Echinococcus granulosus	Pleckstrin y	0.0066	0.0086	0.0085
Schistosoma mansoni	dynamin	0.0066	0.0086	0.0085
Leishmania major	hypothetical protein, conserved	0.0066	0.0086	0.7285
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Brugia malayi	Variant SH3 domain containing protein	0.0066	0.0086	0.0219
Echinococcus granulosus	calcium dependent secretion activator 1	0.0066	0.0086	0.0085
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0002	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Trichomonas vaginalis	centaurin/arf, putative	0.0066	0.0086	0.0718
Echinococcus multilocularis	beta 1 syntrophin	0.0066	0.0086	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Echinococcus multilocularis	actin binding protein anillin	0.0066	0.0086	0.0086
Leishmania major	protein kinase, putative	0.0076	0.0118	1
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0076	0.0118	0.6407
Toxoplasma gondii	protein kinase domain-containing protein	0.0076	0.0118	0.2518
Toxoplasma gondii	hypothetical protein	0.0066	0.0086	0.1834
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0427	0.0425
Trypanosoma cruzi	Protein kinase B	0.0076	0.0118	0.6407
Onchocerca volvulus	outspread protein homolog	0.0066	0.0086	1
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0066	0.0086	0.0219
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Schistosoma mansoni	hypothetical protein	0.0066	0.0086	0.0085
Echinococcus multilocularis	pdz domain containing protein	0.0066	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0076	0.0118	1
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Echinococcus granulosus	myotubularin protein 13	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Echinococcus granulosus	pleckstrin y domain containing family A	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2674	0.8687	0.8687
Brugia malayi	Muscleblind-like protein	0.0169	0.0427	0.1099
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0066	0.0086	0.0085
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0066	0.0086	0.0085
Trypanosoma cruzi	NIMA-related kinase, putative	0.0076	0.0118	0.6407
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Mycobacterium leprae	Probable lipase LipE	0.004	0.0002	0.5
Trypanosoma cruzi	hypothetical protein	0.0066	0.0086	0.4668
Echinococcus multilocularis	myotubularin protein 13	0.0066	0.0086	0.0086
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Echinococcus multilocularis	dynamin 1	0.0066	0.0086	0.0086
Mycobacterium ulcerans	lipase LipD	0.004	0.0002	0.5
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0076	0.0118	0.6407
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0076	0.0118	0.6407
Brugia malayi	Pleckstrin Homology Domain	0.0066	0.0086	0.0219
Brugia malayi	PXA domain containing protein	0.0398	0.1181	0.3047
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0816	0.256	0.2558
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0066	0.0086	0.7285
Echinococcus multilocularis	oxysterol binding protein 1	0.0066	0.0086	0.0086
Echinococcus granulosus	GRB2 associated binding protein 3	0.0066	0.0086	0.0085
Loa Loa (eye worm)	syntrophin-1	0.0066	0.0086	0.0085
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0398	0.1181	0.1181
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0095	0.0183	1
Echinococcus multilocularis	expressed protein	0.0398	0.1181	0.1181
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0076	0.0118	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0066	0.0086	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0076	0.0118	0.6407
Trichomonas vaginalis	centaurin/arf, putative	0.0066	0.0086	0.0718
Brugia malayi	Uncoordinated protein 104	0.0066	0.0086	0.0219
Brugia malayi	hypothetical protein	0.0398	0.1181	0.3047
Leishmania major	serine/threonine-protein kinase a, putative	0.0076	0.0118	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0076	0.0118	0.6407
Schistosoma mansoni	hypothetical protein	0.0066	0.0086	0.0085
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0076	0.0118	0.0116
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0076	0.0118	0.6407
Echinococcus granulosus	DCC interacting protein 13 beta	0.0066	0.0086	0.0085
Loa Loa (eye worm)	uncoordinated protein 104	0.0066	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0183	0.0181
Schistosoma mansoni	zinc finger protein	0.0066	0.0086	0.0085
Loa Loa (eye worm)	Plekhf2 protein	0.0066	0.0086	0.0085
Schistosoma mansoni	serine/threonine protein kinase	0.3072	1	1
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2674	0.8687	0.8687
Toxoplasma gondii	hypothetical protein	0.0066	0.0086	0.1834
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Trypanosoma cruzi	hypothetical protein	0.0066	0.0086	0.4668
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Entamoeba histolytica	p21-activated kinase	0.0076	0.0118	0.0288
Echinococcus granulosus	beta 1 syntrophin	0.0066	0.0086	0.0085
Trichomonas vaginalis	centaurin gamma, putative	0.0066	0.0086	0.0718
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0816	0.256	0.2558
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0076	0.0118	0.0288
Echinococcus multilocularis	oxysterol binding protein 9	0.0066	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0398	0.1181	0.118
Trichomonas vaginalis	hypothetical protein	0.0066	0.0086	0.0718
Echinococcus granulosus	Rho GTPase activating protein 24	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Schistosoma mansoni	z-protein (S1r protein)	0.0398	0.1181	0.118
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0398	0.1181	0.3047
Entamoeba histolytica	protein kinase, putative	0.0076	0.0118	0.0288
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0076	0.0118	0.6407
Echinococcus multilocularis	axis inhibition protein axin	0.0398	0.1181	0.1181
Trypanosoma cruzi	hypothetical protein	0.0066	0.0086	0.4668
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.1181	1
Schistosoma mansoni	oxysterol-binding protein 1	0.0066	0.0086	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.0076	0.0118	0.0986
Brugia malayi	WGR domain containing protein	0.0095	0.0183	0.0469
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0066	0.0086	0.0085
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0398	0.1181	1
Trichomonas vaginalis	protein transport protein sec7, putative	0.0066	0.0086	0.0718
Onchocerca volvulus		0.0066	0.0086	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0398	0.1181	0.1181
Brugia malayi	Cadps2 protein	0.0066	0.0086	0.0219
Schistosoma mansoni	rho gtpase activating protein	0.0066	0.0086	0.0085
Echinococcus granulosus	regulator of G protein signaling 3	0.0398	0.1181	0.118
Brugia malayi	Oxysterol binding protein	0.0066	0.0086	0.0219
Schistosoma mansoni	myotubularin-related protein	0.0066	0.0086	0.0085
Schistosoma mansoni	syntrophin	0.0066	0.0086	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0086	0.0718
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0076	0.0118	0.2518
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0076	0.0118	1
Brugia malayi	TBC domain containing protein	0.0066	0.0086	0.0219
Brugia malayi	probable spectrin beta chain	0.0066	0.0086	0.0219
Onchocerca volvulus	Protein melted homolog	0.0066	0.0086	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0076	0.0118	0.6407
Schistosoma mansoni	axis inhibition protein axin	0.0398	0.1181	0.118
Trypanosoma cruzi	PH domain containing protein, putative	0.0066	0.0086	0.4668
Onchocerca volvulus		0.0066	0.0086	1
Brugia malayi	WGR domain containing protein	0.0174	0.0441	0.1135
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0076	0.0118	0.0288
Entamoeba histolytica	protein kinase, putative	0.0076	0.0118	0.0288
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0002	0.5
Loa Loa (eye worm)	RGS-3 protein	0.0398	0.1181	0.118
Brugia malayi	hypothetical protein	0.0398	0.1181	0.3047
Schistosoma mansoni	goodpasture antigen-binding protein	0.0066	0.0086	0.0085
Schistosoma mansoni	hypothetical protein	0.0066	0.0086	0.0085
Echinococcus multilocularis	axis inhibition protein axin	0.0398	0.1181	0.1181
Brugia malayi	regulator of G-protein signaling egl-10	0.0398	0.1181	0.3047
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0066	0.0086	0.0086
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0066	0.0086	1
Mycobacterium ulcerans	hypothetical protein	0.004	0.0002	0.5
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0398	0.1181	0.118
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0066	0.0086	0.0086
Entamoeba histolytica	protein kinase, putative	0.0076	0.0118	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0398	0.1181	0.118
Trichomonas vaginalis	protein transport protein sec7, putative	0.0066	0.0086	0.0718
Trypanosoma cruzi	hypothetical protein	0.0066	0.0086	0.4668
Schistosoma mansoni	axis inhibition protein axin	0.0398	0.1181	0.118
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0066	0.0086	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.1181	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0076	0.0118	0.0288
Brugia malayi	PH domain containing protein	0.0066	0.0086	0.0219
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0076	0.0118	0.6407
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0076	0.0118	0.0986
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0187	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Entamoeba histolytica	protein kinase, putative	0.0076	0.0118	0.0288
Schistosoma mansoni	hypothetical protein	0.0066	0.0086	0.0085
Brugia malayi	hypothetical protein	0.0066	0.0086	0.0219
Brugia malayi	A-kinase anchor protein 10, precursor	0.0398	0.1181	0.3047
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0086	0.0085
Trypanosoma cruzi	hypothetical protein	0.0066	0.0086	0.4668
Echinococcus multilocularis	Oxysterol binding protein 11	0.0066	0.0086	0.0086

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	= 0.003 uM	Inhibitory effect on the response of isolated ileum to transmural electrical stimulation in guinea pig (anti-TMS activity) was determined	ChEMBL.	7143364

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 25745