Detailed information for compound 26818

Basic information

Technical information
  • TDR Targets ID: 26818
  • Name: 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[ 2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hy droxyethyl]amino]ethanol
  • MW: 405.435 | Formula: C22H25F2NO4
  • H donors: 3 H acceptors: 2 LogP: 3.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O
  • InChi: 1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
  • InChiKey: KOHIRBRYDXPAMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol
  • 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]ethanol
  • 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxy-ethyl]amino]ethanol
  • nebivolol
  • 1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]amino]ethanol
  • 1-(6-fluoro-2-chromanyl)-2-[[2-(6-fluoro-2-chromanyl)-2-hydroxyethyl]amino]ethanol
  • 9920-09-6
  • 99200-09-6
  • 104365-59-5
  • Nebivolol [USAN:BAN:INN]
  • Nebivololum [Latin]
  • R65,824
  • alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
  • alpha,alpha'-(Iminodimethylene)bis(6-fluoro-2-chromanmethanol)
  • PDSP1_000244
  • PDSP2_000243
  • D05127
  • Nebivolol (USAN)
  • 2H-1-Benzopyran-2-methanol, alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, Isk-related family, member 1 Starlite/ChEMBL References
Homo sapiens sodium channel, voltage-gated, type V, alpha subunit Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens calcium channel, voltage-dependent, L type, alpha 1C subunit Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 1 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Mycobacterium ulcerans ion transport protein Get druggable targets OG5_135025 All targets in OG5_135025
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi hypothetical protein potassium voltage-gated channel, Isk-related family, member 1 129 aa 107 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0078 0.0268 0.0893
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0078 0.0265 0.0265
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0415 0.2642
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0025 0.0015
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0108 0.0407 0.1501
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0407 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Loa Loa (eye worm) hypothetical protein 0.0155 0.063 0.238
Giardia lamblia Phosphoglycerate kinase 0.0196 0.0827 0.2734
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0108 0.0407 0.0398
Onchocerca volvulus 0.0056 0.0162 0.0426
Echinococcus granulosus dna polymerase kappa 0.0134 0.0533 0.0524
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0195 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.0134 0.0533 0.3405
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0028 0.0106
Trichomonas vaginalis set domain proteins, putative 0.0517 0.2346 0.7801
Echinococcus granulosus geminin 0.0195 0.0823 0.0814
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0196 0.0827 0.5318
Brugia malayi Pre-SET motif family protein 0.0065 0.0206 0.0736
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0145 0.0547
Treponema pallidum phosphoglycerate kinase 0.0196 0.0827 0.2056
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0071 0.0232 0.1218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0053 0.0148 0.1702
Trypanosoma brucei unspecified product 0.012 0.0464 0.2961
Echinococcus multilocularis geminin 0.0195 0.0823 0.0814
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0108 0.0407 0.0407
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0086 0.0076
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0134 0.0533 0.1698
Schistosoma mansoni bromodomain containing protein 0.0066 0.0212 0.0212
Trichomonas vaginalis DNA polymerase eta, putative 0.0134 0.0533 0.1698
Echinococcus granulosus lamin 0.0056 0.0162 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Leishmania major DNA polymerase eta, putative 0.0105 0.0397 0.2521
Schistosoma mansoni hypothetical protein 0.0195 0.0823 0.0823
Loa Loa (eye worm) hypothetical protein 0.0241 0.1038 0.3922
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0122 0.0474 0.3017
Chlamydia trachomatis phosphoglycerate kinase 0.0196 0.0827 1
Schistosoma mansoni phosphoglycerate kinase 0.0196 0.0827 0.0827
Brugia malayi Cyclic-nucleotide gated cation channel 0.0028 0.0028 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0076 0.0067
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0012 0.0046
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0047 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0226
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0145 0.0882
Loa Loa (eye worm) hypothetical protein 0.0045 0.0111 0.0418
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0189 0.0716
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0244
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0415 0.1174
Loa Loa (eye worm) voltage-dependent calcium channel 0.0034 0.006 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Giardia lamblia Fructose-bisphosphate aldolase 0.0655 0.2999 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0196 0.0827 0.5318
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0086 0.0938
Trypanosoma brucei phosphoglycerate kinase 0.0072 0.0238 0.1492
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Brugia malayi Bromodomain containing protein 0.004 0.0088 0.0288
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.3124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0118 0.0109
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0122 0.0474 0.3021
Treponema pallidum fructose-bisphosphate aldolase 0.0655 0.2999 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0382
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0028 0.0028 0.0106
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0047 0.0047
Leishmania major phosphoglycerate kinase B, cytosolic 0.0196 0.0827 0.5318
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0075 0.0431
Mycobacterium ulcerans glutaminase 0.058 0.2646 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0228 0.0228
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0141 0.0564 0.2094
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.2089 0.2081
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.0407 0.0398
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0129 0.012
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0196 0.0827 0.5643
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0068 0.0223
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0145 0.0135
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0068 0.0218 0.0209
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Brugia malayi hypothetical protein 0.004 0.0086 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0048 0.0068
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0194 0.0185
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Loa Loa (eye worm) hypothetical protein 0.0053 0.0148 0.056
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus multilocularis expressed protein 0.0039 0.008 0.007
Echinococcus multilocularis chromobox protein 1 0.008 0.0278 0.0269
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0852 0.3933 0.3927
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0196 0.0827 0.2688
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus multilocularis lamin dm0 0.0056 0.0162 0.0152
Schistosoma mansoni loxhd1 0.004 0.0086 0.0086
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.0418 0.1877 0.187
Echinococcus granulosus RUN 0.004 0.0086 0.0076
Onchocerca volvulus 0.0036 0.0068 0.0015
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0086 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0086 0.0076
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0012 0.002
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0454 0.2049 0.7743
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0214 0.0911 0.371
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Trypanosoma brucei glucosidase, putative 0.0037 0.0072 0.0407
Onchocerca volvulus 0.004 0.0086 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0756 0.245
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0129 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0056 0.0162 0.0611
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Echinococcus multilocularis sodium channel protein 0.0097 0.0355 0.0346
Brugia malayi Bromodomain containing protein 0.0079 0.0271 0.0981
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0122 0.0474 0.3017
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0068 0.0382
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0083 0.0291 0.0291
Onchocerca volvulus 0.0036 0.0068 0.0015
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0039 0.0101
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0415 0.157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0118 0.0109
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0068 0.0223
Echinococcus multilocularis phosphoglycerate kinase 1 0.0196 0.0827 0.0818
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.2089 0.2081
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0229 0.022
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0076 0.0258 0.0248
Brugia malayi hypothetical protein 0.0241 0.1038 0.3894
Trichomonas vaginalis rotamase, putative 0.0038 0.0075 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.006 0.062
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0212
Trichomonas vaginalis glutaminase, putative 0.058 0.2646 0.8811
Schistosoma mansoni alpha-glucosidase 0.0143 0.0574 0.0574
Leishmania major DNA polymerase eta, putative 0.0053 0.0148 0.0905
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0145 0.0882
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0162 0.0611
Brugia malayi PHD-finger family protein 0.0026 0.0021 0.0035
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0678 0.4349
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0145 0.1658
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.0987 0.6839
Schistosoma mansoni microtubule-associated protein tau 0.2133 1 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0196 0.0827 0.5318
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0086 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0232 0.0222
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0258 0.0974
Echinococcus multilocularis chromobox protein 1 0.008 0.0278 0.0269
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0407 0.0398
Trypanosoma brucei protein kinase, putative 0.0052 0.0145 0.0882
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0078 0.0265 0.1462
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0088 0.0334
Brugia malayi jmjC domain containing protein 0.0068 0.0218 0.0783
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0047 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.01 0.0378
Echinococcus multilocularis RUN 0.004 0.0086 0.0076
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.0418 0.1877 0.187
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1038 0.1029
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0012 0.0003
Toxoplasma gondii hypothetical protein 0.0056 0.0163 0.1886
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0068 0.0719
Schistosoma mansoni chromobox protein 0.008 0.0278 0.0278
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0068 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus muscleblind protein 0.0172 0.0713 0.0704
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0141 0.0564 0.0564
Echinococcus multilocularis muscleblind protein 1 0.0172 0.0713 0.0704
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0196 0.0827 1
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0127 0.0332
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0047 0.0047
Echinococcus granulosus GPCR family 2 0.0049 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0129 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0048 0.0068
Echinococcus granulosus chromobox protein 1 0.008 0.0278 0.0269
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0228 0.0228
Giardia lamblia DINP protein human, muc B family 0.009 0.0326 0.1059
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0039 0.0147
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0106
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0076
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0071 0.0235 0.1471
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0228 0.0219
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0129 0.0444
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0145 0.0882
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0155 0.0427
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0129 0.012
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0071 0.0232 0.0833
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0258 0.0249
Brugia malayi beta-lactamase family protein 0.0036 0.0068 0.0212
Brugia malayi ImpB/MucB/SamB family protein 0.0105 0.0397 0.146
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0075 0.081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Schistosoma mansoni chromobox protein 0.008 0.0278 0.0278
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.2089 0.2081
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0063 0.0197 0.0745
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0068 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus granulosus chromobox protein 1 0.008 0.0278 0.0269
Brugia malayi Phosphoglycerate kinase 0.0072 0.0238 0.0859
Echinococcus multilocularis hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0145 0.0135
Schistosoma mansoni lipoxygenase 0.0238 0.1025 0.1025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.0094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Echinococcus multilocularis microtubule associated protein 2 0.2133 1 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Brugia malayi beta-lactamase 0.0036 0.0068 0.0212
Schistosoma mansoni phosphoglycerate kinase 0.0196 0.0827 0.0827
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0111 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0398 0.1465
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0122 0.0474 0.3021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0129 0.0488
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0078 0.0265 0.1462
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0063 0.0197 0.0188
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0258 0.0933
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0141 0.0564 0.0555
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0229 0.0229
Onchocerca volvulus 0.0517 0.2346 1
Trichomonas vaginalis esterase, putative 0.0036 0.0068 0.0134
Trypanosoma brucei phosphoglycerate kinase 0.0196 0.0827 0.5318
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0108 0.0407 0.0398
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0075 0.0013
Loa Loa (eye worm) hypothetical protein 0.0172 0.0713 0.2695
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.0766 0.5192
Brugia malayi glutaminase DH11.1 0.058 0.2646 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.1546 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.063 0.2345
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0129 0.0444
Loa Loa (eye worm) voltage-gated potassium channel 0.0123 0.0482 0.1822
Echinococcus multilocularis musashi 0.0056 0.0162 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0082 0.0284 0.1073
Echinococcus multilocularis lysine specific demethylase 5A 0.0068 0.0218 0.0209
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.0796
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.032 0.1412 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0407 0.0398
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0229 0.022
Loa Loa (eye worm) beta-lactamase 0.0036 0.0068 0.0257
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0141 0.0564 0.0555
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0108 0.0407 0.0398
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0179
Trypanosoma brucei polo-like protein kinase 0.0109 0.0415 0.2642
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0258 0.0258
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0145 0.0135
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0072 0.0407
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0415 0.0406
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0206 0.0197
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0196 0.0827 0.2688
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0284 0.1788
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0076 0.0258 0.0974
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.032 0.1412 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0196 0.0827 0.5643
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0145 0.0453
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0068 0.0382
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0258 0.0636
Schistosoma mansoni rab6-interacting 0.004 0.0086 0.0086
Schistosoma mansoni lamin 0.0056 0.0162 0.0162
Onchocerca volvulus 0.0096 0.0352 0.1259
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0407
Schistosoma mansoni DNA polymerase eta 0.0105 0.0397 0.0397
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0086 0.0938
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Trichomonas vaginalis rotamase, putative 0.0039 0.008 0.0174
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0148 0.0905
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0118 0.0109
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0072 0.0238 0.1492
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0324
Trypanosoma brucei DNA polymerase IV, putative 0.0134 0.0533 0.3405
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0678 0.4349
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.1546 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Trypanosoma brucei phosphoglycerate kinase 0.0196 0.0827 0.5318
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0071 0.0235 0.1471
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0118 0.0109
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0418 0.1877 0.1877
Loa Loa (eye worm) hypothetical protein 0.0214 0.0911 0.3443
Schistosoma mansoni terminal deoxycytidyl transferase 0.0076 0.0258 0.0258
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0162 0.0567
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0072 0.0226
Brugia malayi N-terminal motif family protein 0.0214 0.0911 0.3413
Echinococcus multilocularis GPCR, family 2 0.0049 0.0129 0.012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.0217 0.0217
Schistosoma mansoni hypothetical protein 0.0195 0.0823 0.0823
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0134
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0218 0.0218
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0068 0.0218 0.0209
Onchocerca volvulus 0.004 0.0086 0.0094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0683 0.2582
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0127 0.0273
Leishmania major calcium channel protein, putative,ion transporter, putative 0.006 0.018 0.1108
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0129 0.0781
Schistosoma mansoni hypothetical protein 0.0049 0.0129 0.0129
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0145 0.0135
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0415 0.2642
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0229 0.2688
Schistosoma mansoni rotamase 0.0039 0.008 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0028 0.0028
Brugia malayi Pre-SET motif family protein 0.0454 0.2049 0.7732
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0097 0.0355 0.0346
Loa Loa (eye worm) hypothetical protein 0.0045 0.011 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Brugia malayi hypothetical protein 0.004 0.0086 0.028
Schistosoma mansoni intermediate filament proteins 0.0056 0.0162 0.0162
Trypanosoma cruzi DNA polymerase eta, putative 0.0105 0.0397 0.2521
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0012 0.0003
Echinococcus multilocularis lamin 0.0056 0.0162 0.0152
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0108 0.0407 0.0407
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0155 0.0427
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0012 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0116 0.0295
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Echinococcus multilocularis dna polymerase kappa 0.0134 0.0533 0.0524
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0086 0.0076
Loa Loa (eye worm) pre-B cell enhancing factor 0.0418 0.1877 0.7096
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0072 0.0147
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0415 0.1538
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0415 0.2642
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0206 0.2406
Echinococcus granulosus lamin dm0 0.0056 0.0162 0.0152
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0324
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0083 0.0291 0.0281
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0258 0.1617
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0012 0.0046
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0047 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.0083 0.0291 0.0281
Schistosoma mansoni alpha-glucosidase 0.0143 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0083 0.0291 0.1099
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0072 0.0062
Plasmodium falciparum M17 leucyl aminopeptidase 0.0122 0.0474 0.5681
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0076 0.0258 0.0258
Loa Loa (eye worm) glutaminase 0.058 0.2646 1
Trypanosoma brucei unspecified product 0.0052 0.0146 0.0889
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.1546 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0028 0.0028 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0206 0.0206
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0407 0.0398
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Schistosoma mansoni hypothetical protein 0.0053 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0942
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0194 0.0185
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0012 0.0012
Trypanosoma brucei unspecified product 0.0052 0.0146 0.0889
Trichomonas vaginalis chromobox protein, putative 0.008 0.0278 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0214 0.1333
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.013 0.0447
Mycobacterium ulcerans hypothetical protein 0.0036 0.0068 0.0223
Schistosoma mansoni polycystin 1-related 0.004 0.0086 0.0086
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0046 0.0116 0.0295
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Loa Loa (eye worm) doublecortin family protein 0.004 0.0086 0.0324
Mycobacterium ulcerans DNA polymerase IV 0.0134 0.0533 0.1985
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0145 0.0145
Schistosoma mansoni lamin 0.0056 0.0162 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0076 0.0067
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0229 0.1197
Giardia lamblia Kinase, PLK 0.0109 0.0415 0.1358
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0012 0.0003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0075 0.0431
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0118 0.0402
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0063 0.0197 0.0703
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0075 0.0431
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1038 0.1029
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0122 0.0474 0.3021
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0415 0.1304
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0232 0.0844
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0198 0.0837 0.3133
Mycobacterium ulcerans leucyl aminopeptidase 0.0122 0.0474 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.008 0.0174
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0145 0.0882
Plasmodium falciparum phosphoglycerate kinase 0.0196 0.0827 1
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0278 0.105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0071 0.0232 0.0844
Trypanosoma brucei phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Entamoeba histolytica deoxycytidyl transferase, putative 0.0076 0.0258 0.0635
Mycobacterium ulcerans beta-lactamase 0.0036 0.0068 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0415 0.0415
Echinococcus granulosus phosphoglycerate kinase 1 0.0196 0.0827 0.0818
Entamoeba histolytica phosphoglycerate kinase, putative 0.0196 0.0827 0.2579
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0075 0.0431
Toxoplasma gondii leucyl aminopeptidase LAP 0.0122 0.0474 0.5681
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0012 0.0012
Echinococcus granulosus expressed protein 0.0039 0.008 0.007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0076 0.0258 0.0248
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0071 0.0232 0.1447
Echinococcus granulosus neuropeptide s receptor 0.0463 0.2089 0.2081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0678 0.4349
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0063 0.0197 0.0188
Toxoplasma gondii ABC1 family protein 0.0036 0.0068 0.0719
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0122 0.0474 0.5681
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0145 0.0882
Brugia malayi Phosphoglycerate kinase 0.0196 0.0827 0.3093
Loa Loa (eye worm) hypothetical protein 0.0198 0.0837 0.3165
Loa Loa (eye worm) hypothetical protein 0.0105 0.0397 0.15
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0068 0.0212
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0009 0.0009
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0415 0.0406
Plasmodium vivax phosphoglycerate kinase, putative 0.0196 0.0827 1
Schistosoma mansoni rab6-interacting 0.004 0.0086 0.0086
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0047 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Trypanosoma brucei DNA polymerase eta, putative 0.0105 0.0397 0.2521
Trypanosoma brucei DNA polymerase kappa, putative 0.009 0.0326 0.206
Mycobacterium ulcerans phosphoglycerate kinase 0.0196 0.0827 0.31
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0229 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Loa Loa (eye worm) hypothetical protein 0.0108 0.0407 0.154
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0229 0.0229
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0028 0.0028 0.0019
Brugia malayi Muscleblind-like protein 0.0172 0.0713 0.2661
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.0659
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0028 0.0028 0.0019
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0106 0.0097
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0145 0.0882
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0655 0.2999 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0162 0.0611
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0028 0.0028 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0655 0.2999 1
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0086 0.0076
Onchocerca volvulus 0.0056 0.0162 0.0426
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0196 0.0827 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0068 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0068 0.0134
Trypanosoma brucei DNA polymerase IV, putative 0.012 0.0464 0.2961
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0072 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0072 0.0407
Schistosoma mansoni alpha glucosidase 0.0037 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0111 0.0278
Brugia malayi intermediate filament protein 0.0056 0.0162 0.0567
Schistosoma mansoni lipoxygenase 0.0166 0.0686 0.0686
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.009 0.0326 0.206
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0072 0.0765
Schistosoma mansoni survival motor neuron protein 0.0049 0.013 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0111 0.0278
Loa Loa (eye worm) hypothetical protein 0.0172 0.0713 0.2695
Trichomonas vaginalis chromobox protein, putative 0.008 0.0278 0.0841
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0145 0.0882
Echinococcus granulosus sodium channel protein 0.006 0.018 0.017
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0028 0.0028 0.0019
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.004 0.0086 0.0086
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0683 0.0674
Echinococcus granulosus hyperpolarization activated cyclic 0.0028 0.0028 0.0019
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0196 0.0827 1
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0228 0.0862
Echinococcus granulosus Solute carrier family 22 5 0.125 0.5818 0.5814
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.009 0.0326 0.1918
Brugia malayi Pre-B cell enhancing factor precursor 0.0418 0.1877 0.7082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0078 0.0268 0.0268
Plasmodium vivax SET domain protein, putative 0.0065 0.0206 0.2406
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0071 0.0232 0.0232
Brugia malayi jmjC domain containing protein 0.007 0.0228 0.0819
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.1546 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0238 0.1025 0.1017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.018 0.1111
Echinococcus granulosus dna polymerase eta 0.0105 0.0397 0.0388
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.063 0.2345
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0229 0.1429
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0068 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0145 0.0393
Schistosoma mansoni voltage-gated potassium channel 0.0067 0.0217 0.0217
Echinococcus multilocularis leucine aminopeptidase protein 0.0122 0.0474 0.0465
Leishmania major hypothetical protein, conserved 0.0036 0.0068 0.0382
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.032 0.1412 0.5322
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.0183 0.0766 0.287
Loa Loa (eye worm) hypothetical protein 0.0055 0.0157 0.0592
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.008 0.0256
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0071 0.0232 0.0222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0118 0.0118
Brugia malayi polk-prov protein 0.0082 0.0284 0.1032
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0076
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0238 0.1025 0.1017
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0415 0.1531
Brugia malayi Heterochromatin protein 1 0.008 0.0278 0.1008
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0028 0.0028 0.0019
Echinococcus multilocularis dna polymerase eta 0.0105 0.0397 0.0388
Mycobacterium ulcerans DNA polymerase IV 0.0134 0.0533 0.1985
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0118 0.0446
Mycobacterium tuberculosis Conserved hypothetical protein 0.0076 0.0258 0.1411
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0258 0.0249
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0122 0.0474 0.3021
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0068 0.0134
Leishmania major DNA polymerase kappa, putative 0.009 0.0326 0.206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.063 0.238
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0533 0.3405
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0238 0.1492
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Schistosoma mansoni hypothetical protein 0.0049 0.013 0.013
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0127 0.0332
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0407 0.0398
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0683 0.2547
Mycobacterium ulcerans lipase LipD 0.0036 0.0068 0.0223
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.008 0.0301
Mycobacterium ulcerans ion transport protein 0.0093 0.0336 0.1241
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0028 0.0028
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0038 0.0077 0.0834
Onchocerca volvulus 0.0036 0.0068 0.0015
Loa Loa (eye worm) glutaminase 2 0.058 0.2646 1
Onchocerca volvulus 0.0049 0.013 0.0287
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0129 0.0781
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0106 0.0097
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0407 0.0398
Schistosoma mansoni hypothetical protein 0.0106 0.0398 0.0398
Schistosoma mansoni kinase 0.0056 0.0162 0.0162
Brugia malayi chromobox protein homolog 3 0.0045 0.0111 0.0374
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0072 0.0147
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0078 0.0265 0.1661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0257
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0047 0.0038
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0028 0.0028 0.0028
Schistosoma mansoni voltage-gated cation channel 0.0108 0.0407 0.0407
Echinococcus granulosus intermediate filament protein 0.0056 0.0162 0.0152
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.0258 0.0932
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0284 0.1788
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0078 0.0265 0.0265
Echinococcus multilocularis muscleblind protein 0.0172 0.0713 0.0704
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0072 0.0271
Loa Loa (eye worm) calcium channel 0.0108 0.0407 0.154
Brugia malayi MAP kinase sur-1 0.0052 0.0145 0.0503
Schistosoma mansoni glutaminase 0.058 0.2646 0.2646
Loa Loa (eye worm) hypothetical protein 0.0106 0.0398 0.1504
Brugia malayi Doublecortin family protein 0.004 0.0086 0.028
Echinococcus granulosus leucine aminopeptidase protein 0.0122 0.0474 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0072 0.0147
Loa Loa (eye worm) hypothetical protein 0.0196 0.0827 0.3124
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0258 0.1617

Activities

Activity type Activity value Assay description Source Reference
Fu (ADMET) = 0.02 Unbound fraction (plasma) ChEMBL. 14971904
IC50 (functional) = 4.4 Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells transfected with KCNQ1 / Kv1 LITERATURE. 25087753
IC50 (functional) = 4.8 Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using IonWorks Quattro automated patch clamp platform LITERATURE. 25087753
pKa = 8.22 Ionization constant (pKa) ChEMBL. 14971904
Vdss (ADMET) = 11.2 l kg-1 Observed volume of distribution ChEMBL. 14971904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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