Detailed information for compound 27313

Basic information

Technical information
  • TDR Targets ID: 27313
  • Name: (2,6-ditert-butyl-4-methylphenyl) N-(benzhydr ylsulfamoyl)carbamate
  • MW: 508.672 | Formula: C29H36N2O4S
  • H donors: 2 H acceptors: 3 LogP: 7.7 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NS(=O)(=O)NC(c1ccccc1)c1ccccc1)Oc1c(cc(cc1C(C)(C)C)C)C(C)(C)C
  • InChi: 1S/C29H36N2O4S/c1-20-18-23(28(2,3)4)26(24(19-20)29(5,6)7)35-27(32)31-36(33,34)30-25(21-14-10-8-11-15-21)22-16-12-9-13-17-22/h8-19,25,30H,1-7H3,(H,31,32)
  • InChiKey: YUFPFUGZFYYUCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2,6-ditert-butyl-4-methyl-phenyl) N-(benzhydrylsulfamoyl)carbamate
  • N-(benzhydrylsulfamoyl)carbamic acid (2,6-ditert-butyl-4-methylphenyl) ester
  • N-(benzhydrylsulfamoyl)carbamic acid (2,6-ditert-butyl-4-methyl-phenyl) ester
  • (2,6-ditert-butyl-4-methylphenyl) N-[di(phenyl)methylsulfamoyl]carbamate
  • (2,6-ditert-butyl-4-methyl-phenyl) N-[di(phenyl)methylsulfamoyl]carbamate
  • N-[di(phenyl)methylsulfamoyl]carbamic acid (2,6-ditert-butyl-4-methylphenyl) ester
  • N-[di(phenyl)methylsulfamoyl]carbamic acid (2,6-ditert-butyl-4-methyl-phenyl) ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone deacetylase 7 0.0639 0.2141 0.5869
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0011 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0052 0.0133
Loa Loa (eye worm) hypothetical protein 0.0084 0.0213 0.0555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0169 0.0169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Echinococcus multilocularis laminin 0.0039 0.0057 0.0157
Schistosoma mansoni cpg binding protein 0.0032 0.0031 0.0031
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0169 0.0465
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0169 0.0539
Echinococcus granulosus calpain 5 0.0043 0.0071 0.0193
Loa Loa (eye worm) hypothetical protein 0.042 0.1382 0.3769
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0169 0.0366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.059 0.1618
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0181 0.0488
Plasmodium falciparum plasmepsin VI 0.091 0.3082 1
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0095 0.0252 0.0692
Loa Loa (eye worm) hypothetical protein 0.0484 0.1604 0.438
Echinococcus multilocularis histone deacetylase 6 0.0689 0.2314 0.6342
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Schistosoma mansoni ap endonuclease 0.0038 0.0052 0.0052
Loa Loa (eye worm) inositol-1 0.0115 0.0322 0.0857
Trypanosoma brucei oligopeptidase b 0.0427 0.1403 0.3828
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0312 0.1002
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.005 0.0094 0.0229
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.1604 0.5199
Onchocerca volvulus Prolyl endopeptidase homolog 0.1073 0.3648 1
Schistosoma mansoni hypothetical protein 0.0175 0.0531 0.0531
Mycobacterium tuberculosis Probable peptidase 0.0427 0.1403 0.4216
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.005 0.0094 0.0248
Trypanosoma cruzi oligopeptidase b 0.0427 0.1403 0.3841
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0011 0.0023
Plasmodium vivax RNA helicase-1, putative 0.0095 0.0252 0.0787
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.005 0.0094 0.0229
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.005 0.0094 0.0293
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.0732 0.2006
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0113 0.0312 0.0312
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0103 0.0301
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0184
Loa Loa (eye worm) hypothetical protein 0.0256 0.081 0.2198
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.005 0.0094 0.0248
Leishmania major hypothetical protein, conserved 0.0071 0.0169 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Brugia malayi Bromodomain containing protein 0.0041 0.0065 0.0148
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0095 0.0252 0.0683
Onchocerca volvulus 0.0259 0.082 0.2226
Plasmodium vivax aspartyl protease, putative 0.0259 0.082 0.2636
Loa Loa (eye worm) hypothetical protein 0.0071 0.0169 0.0436
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0322 0.1036
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.005 0.0094 0.0257
Schistosoma mansoni neprilysin 0.0221 0.0691 0.0691
Leishmania major glycerol uptake protein, putative 0.0026 0.0011 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Loa Loa (eye worm) hypothetical protein 0.0101 0.0272 0.0719
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.0312 0.0828
Brugia malayi calpain family protein 1 0.0114 0.0317 0.0842
Trypanosoma cruzi GUP1, putative 0.0026 0.0011 0.002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.005 0.0094 0.0248
Plasmodium falciparum importin beta, putative 0.0029 0.0023 0.0039
Loa Loa (eye worm) hypothetical protein 0.0113 0.0312 0.0828
Toxoplasma gondii aspartyl protease ASP3 0.0663 0.2226 0.6089
Loa Loa (eye worm) beta-lactamase 0.0071 0.0169 0.0436
Entamoeba histolytica hypothetical protein, conserved 0.0113 0.0312 0.1928
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0115 0.0322 0.0857
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0128
Brugia malayi hypothetical protein 0.003 0.0025 0.004
Trichomonas vaginalis porcupine, putative 0.0026 0.0011 0.0023
Plasmodium falciparum histone deacetylase 1 0.0484 0.1604 0.5187
Toxoplasma gondii exonuclease III APE 0.0038 0.0052 0.0114
Loa Loa (eye worm) hypothetical protein 0.0076 0.0186 0.0481
Treponema pallidum ATP-dependent RNA helicase 0.0095 0.0252 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0114 0.0285
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.004
Echinococcus granulosus transmembrane protease serine 3 0.003 0.0025 0.0069
Brugia malayi Kringle domain containing protein 0.0075 0.0181 0.0469
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.016 0.0429
Loa Loa (eye worm) calpain 0.0043 0.0071 0.0164
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0011 0.002
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.005 0.0094 0.0229
Echinococcus multilocularis endothelin converting enzyme 1 0.0849 0.2869 0.7865
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0071 0.0071
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0071 0.0164
Onchocerca volvulus 0.003 0.0025 0.004
Echinococcus granulosus tissue type plasminogen activator 0.0075 0.0181 0.0497
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0011 0.0029
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0011 0.0029
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0039 0.0057 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0011 0.0023
Plasmodium falciparum plasmepsin III 0.0259 0.082 0.2636
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0011 0.0029
Echinococcus multilocularis calpain A 0.0119 0.0335 0.0919
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.005 0.0094 0.0271
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0184
Brugia malayi calpain family protein 1 0.0114 0.0317 0.0842
Echinococcus multilocularis cpg binding protein 0.0032 0.0031 0.0086
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0095 0.0252 0.0683
Plasmodium vivax histone deacetylase, putative 0.0256 0.081 0.2603
Loa Loa (eye worm) hypothetical protein 0.0238 0.0748 0.2028
Echinococcus multilocularis glycoprotein Antigen 5 0.003 0.0025 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.004
Plasmodium vivax aspartyl proteinase, putative 0.0259 0.082 0.2636
Onchocerca volvulus 0.003 0.0025 0.004
Echinococcus multilocularis fibrillin 1 0.0039 0.0057 0.0157
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.091 0.3082 0.8443
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0056 0.0153
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0095 0.0252 0.0625
Brugia malayi calpain 5 0.003 0.0026 0.0041
Brugia malayi CXXC zinc finger family protein 0.0028 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0075 0.0181 0.0181
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.005 0.0094 0.0248
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0103 0.028 0.0712
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.005 0.0094 0.0257
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.005 0.0094 0.0229
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0128 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0169 0.0455
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.1604 0.5199
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0052 0.0134
Leishmania major hypothetical protein, conserved 0.005 0.0094 0.0248
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.004
Brugia malayi hypothetical protein 0.0034 0.0039 0.0077
Brugia malayi beta-lactamase family protein 0.0071 0.0169 0.0436
Echinococcus multilocularis tissue type plasminogen activator 0.0075 0.0181 0.0497
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0052 0.0114
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.0312 0.0828
Schistosoma mansoni inositol monophosphatase 0.0115 0.0322 0.0322
Plasmodium falciparum eukaryotic initiation factor 4A 0.0095 0.0252 0.0787
Echinococcus granulosus cpg binding protein 0.0032 0.0031 0.0086
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0011 0.0045
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.005 0.0094 0.0229
Brugia malayi BRCA1-associated protein 2 containing protein 0.005 0.0094 0.0229
Brugia malayi beta-lactamase family protein 0.0071 0.0169 0.0436
Schistosoma mansoni cpg binding protein 0.0032 0.0031 0.0031
Onchocerca volvulus 0.003 0.0025 0.004
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0095 0.0252 0.0665
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Loa Loa (eye worm) TK/ROR protein kinase 0.0075 0.0181 0.0469
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.003 0.0025 0.0069
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.003 0.0025 0.0069
Schistosoma mansoni survival motor neuron protein 0.0048 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.005 0.0094 0.0293
Giardia lamblia Alanyl dipeptidyl peptidase 0.0113 0.0312 0.1676
Leishmania major histone deacetylase, putative 0.0484 0.1604 0.4391
Leishmania major glycerol uptake protein, putative 0.0026 0.0011 0.002
Schistosoma mansoni hypothetical protein 0.0026 0.0011 0.0011
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.005 0.0094 0.0094
Trypanosoma cruzi GUP1, putative 0.0026 0.0011 0.002
Schistosoma mansoni neprilysin-2 (M13 family) 0.0428 0.1409 0.1409
Brugia malayi Pepsin A precursor 0.0259 0.082 0.2226
Schistosoma mansoni brca1-associated protein (brap2) 0.005 0.0094 0.0094
Schistosoma mansoni histone deacetylase 1 2 3 0.0256 0.081 0.081
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0071 0.0184
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.005 0.0094 0.0257
Plasmodium vivax aspartyl protease, putative 0.0663 0.2226 0.7212
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0184
Toxoplasma gondii hypothetical protein 0.0113 0.0312 0.0828
Brugia malayi Histone deacetylase 1 0.0484 0.1604 0.438
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0095 0.0252 0.0692
Brugia malayi PHD-finger family protein 0.0028 0.002 0.0025
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0169 0.0507
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.1604 0.5199
Entamoeba histolytica prolyl oligopeptidase family protein 0.0113 0.0312 0.1928
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0052 0.0133
Plasmodium falciparum plasmepsin I 0.091 0.3082 1
Plasmodium falciparum plasmepsin IX 0.0663 0.2226 0.7212
Echinococcus granulosus histone deacetylase 3 0.0484 0.1604 0.4397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Trypanosoma cruzi prolyl endopeptidase 0.1073 0.3648 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0103 0.0301
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0056 0.0153
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Schistosoma mansoni histone deacetylase hda2 0.0256 0.081 0.081
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0113 0.0312 0.0846
Echinococcus granulosus snurportin 1 0.0312 0.1006 0.2758
Schistosoma mansoni hypothetical protein 0.003 0.0025 0.0025
Echinococcus granulosus geminin 0.0175 0.0531 0.1454
Leishmania major glycerol uptake protein, putative 0.0026 0.0011 0.002
Brugia malayi Trypsin family protein 0.003 0.0025 0.004
Plasmodium falciparum cysteine repeat modular protein 1 0.0075 0.0181 0.0556
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.005 0.0094 0.0229
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.005 0.0094 0.0257
Brugia malayi Protein kinase domain containing protein 0.0075 0.0181 0.0469
Onchocerca volvulus 0.0117 0.0327 0.0869
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0052 0.1709
Echinococcus granulosus acylamino acid releasing enzyme 0.0113 0.0312 0.0855
Echinococcus multilocularis hypothetical protein 0.0043 0.0071 0.0193
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0849 0.2869 0.879
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.005 0.0094 0.0248
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0128
Brugia malayi hypothetical protein 0.0259 0.082 0.2226
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0322 0.0875
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0113 0.0312 0.1928
Loa Loa (eye worm) histone deacetylase 3 0.0484 0.1604 0.438
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0011 0.0029
Entamoeba histolytica hypothetical protein 0.0026 0.0011 0.0045
Plasmodium vivax hypothetical protein, conserved 0.005 0.0094 0.0271
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0103 0.0254
Loa Loa (eye worm) zinc metallopeptidase 4 0.0207 0.0639 0.1728
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0113 0.0312 0.0828
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0071 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0169 0.0436
Plasmodium falciparum peptidase, putative 0.0113 0.0312 0.0981
Echinococcus multilocularis histone deacetylase 1 0.0484 0.1604 0.4397
Plasmodium falciparum plasmepsin V 0.0259 0.082 0.2636
Echinococcus multilocularis histone deacetylase 3 0.0484 0.1604 0.4397
Loa Loa (eye worm) hypothetical protein 0.0071 0.0169 0.0436
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.0335 0.0335
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.005 0.0094 0.0229
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0113 0.0312 0.1002
Plasmodium falciparum plasmepsin II 0.091 0.3082 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0039 0.0057 0.0128
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0322 0.0875
Brugia malayi aspartic protease BmAsp-2, identical 0.0259 0.082 0.2226
Loa Loa (eye worm) hypothetical protein 0.0071 0.0169 0.0436
Plasmodium vivax histone deacetylase, putative 0.0639 0.2141 0.6936
Leishmania major kinesin, putative 0.003 0.0026 0.0061
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0095 0.0252 0.0808
Echinococcus granulosus enteropeptidase 0.003 0.0025 0.0069
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1073 0.3648 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0169 0.0436
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0113 0.0312 0.0828
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.003 0.0025 0.0069
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0052 0.0303
Leishmania major eukaryotic initiation factor 4a, putative 0.0095 0.0252 0.0683
Trichomonas vaginalis brca1-associated protein, putative 0.005 0.0094 0.0293
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0128
Leishmania major cathepsin L-like protease 0.0069 0.016 0.0429
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.0838 0.0838
Entamoeba histolytica calpain large subunit domain III containing protein 0.003 0.0026 0.0138
Mycobacterium ulcerans zinc metalloprotease 0.0849 0.2869 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.005 0.0094 0.0293
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0169 0.0539
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0642 0.2151 0.5885
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0011 0.0029
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0115 0.0322 0.1992
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0003 0.0008
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0169 0.0507
Entamoeba histolytica protein kinase, putative 0.003 0.0026 0.0138
Echinococcus granulosus histone deacetylase 0.0639 0.2141 0.5869
Onchocerca volvulus 0.0071 0.0169 0.0436
Brugia malayi Trypsin family protein 0.0117 0.0327 0.0869
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0115 0.0322 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0087 0.0208
Loa Loa (eye worm) hypothetical protein 0.0259 0.082 0.2226
Toxoplasma gondii histone deacetylase HDAC5 0.0256 0.081 0.2198
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0095 0.0252 0.0665
Plasmodium falciparum plasmepsin VII 0.0259 0.082 0.2636
Schistosoma mansoni hypothetical protein 0.0175 0.0531 0.0531
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.0327 0.0327
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Onchocerca volvulus 0.0075 0.0181 0.0469
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0113 0.0312 0.0828
Brugia malayi eukaryotic initiation factor 4A 0.0095 0.0252 0.0665
Brugia malayi Trypsin family protein 0.003 0.0025 0.004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1073 0.3648 0.3648
Trypanosoma brucei antigen, putative 0.0043 0.0071 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0023 0.0033
Echinococcus multilocularis enteropeptidase 0.003 0.0025 0.0069
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0119 0.0335 0.0919
Echinococcus granulosus prolyl endopeptidase 0.1073 0.3648 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0427 0.1403 0.4216
Onchocerca volvulus 0.0028 0.0019 0.0021
Echinococcus multilocularis snurportin 1 0.0312 0.1006 0.2758
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0169 0.0517
Loa Loa (eye worm) histone deacetylase 0.0639 0.2141 0.5857
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0113 0.0312 0.1928
Trypanosoma cruzi histone deacetylase 1, putative 0.0484 0.1604 0.4391
Loa Loa (eye worm) calpain 5 0.003 0.0026 0.0041
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0095 0.0252 0.0252
Trypanosoma cruzi kinesin, putative 0.003 0.0026 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0011 0.0023
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0428 0.1409 0.1409
Trypanosoma cruzi oligopeptidase b 0.0427 0.1403 0.3841
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.059 0.1618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Leishmania major glycerol uptake protein, putative 0.0026 0.0011 0.002
Onchocerca volvulus 0.0071 0.0168 0.0432
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0011 0.0011
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0113 0.0312 0.0828
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Leishmania major histone deacetylase, putative 0.0484 0.1604 0.4391
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.005 0.0094 0.0229
Brugia malayi calpain 7 0.0043 0.0071 0.0164
Loa Loa (eye worm) aspartic protease BmAsp-2 0.091 0.3082 0.8443
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0849 0.2869 0.7859
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.005 0.0094 0.0229
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0259 0.082 0.2226
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0484 0.1604 0.5199
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0312 0.0846
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0052 0.0094
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0011 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.059 0.059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.059 0.059
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0011 0.003
Onchocerca volvulus Histone deacetylase 10 homolog 0.0256 0.081 0.2198
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0114 0.0317 0.0317
Mycobacterium leprae probable zinc metalloprotease 0.0849 0.2869 1
Plasmodium falciparum plasmepsin X 0.0663 0.2226 0.7212
Entamoeba histolytica histone deacetylase, putative 0.0484 0.1604 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0025 0.0025
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0011 0.0045
Brugia malayi Histone deacetylase family protein 0.0639 0.2141 0.5857
Brugia malayi histone deacetylase 3 (HD3) 0.0484 0.1604 0.438
Leishmania major histone deacetylase, putative 0.0639 0.2141 0.5865
Schistosoma mansoni ap endonuclease 0.0038 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0071 0.0169 0.0436
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0428 0.1409 0.1409
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.005 0.0094 0.0229
Loa Loa (eye worm) prolyl oligopeptidase 0.0113 0.0312 0.0828
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0184
Echinococcus multilocularis histone deacetylase 6 0.0639 0.2141 0.5869
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0075 0.0181 0.0556
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.0312 0.0828
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0039 0.0057 0.0128
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0113 0.0312 0.0855
Onchocerca volvulus Arrow homolog 0.0039 0.0057 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.059 0.1618
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0169 0.0539
Brugia malayi Bromodomain containing protein 0.0082 0.0207 0.0541
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.005 0.0094 0.0564
Loa Loa (eye worm) hypothetical protein 0.0849 0.2869 0.7859
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.059 0.1618
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0023 0.0033
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0011 0.0029
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.091 0.3082 0.8448
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0052 0.0143
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.1006 0.2736
Trypanosoma brucei prolyl oligopeptidase, putative 0.0427 0.1403 0.3828
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0043 0.0071 0.0164
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0011 0.0011
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0011 0.0045
Schistosoma mansoni hypothetical protein 0.003 0.0025 0.0025
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.0838 0.2297
Trichomonas vaginalis inositol monophosphatase, putative 0.0115 0.0322 0.1036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0169 0.0169
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.005 0.0094 0.0564
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0114 0.0317 0.0842
Onchocerca volvulus 0.042 0.1382 0.3769
Brugia malayi RNA, U transporter 1 0.0083 0.021 0.0548
Loa Loa (eye worm) calpain family protein 1 0.0084 0.0213 0.0555
Trypanosoma brucei prolyl endopeptidase 0.1073 0.3648 1
Onchocerca volvulus 0.003 0.0025 0.004
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0312 0.0981
Plasmodium vivax calpain, putative 0.0043 0.0071 0.0195
Schistosoma mansoni cathepsin D (A01 family) 0.2901 1 1
Brugia malayi Trypsin family protein 0.003 0.0025 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.059 0.059
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0011 0.0029
Plasmodium falciparum plasmepsin VIII, putative 0.0259 0.082 0.2636
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0139 0.0372
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0023 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0117 0.0327 0.0327
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0039 0.0057 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Schistosoma mansoni hypothetical protein 0.0221 0.0691 0.0691
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0039 0.0057 0.0128
Loa Loa (eye worm) peptidase family M13 containing protein 0.0627 0.21 0.5744
Plasmodium vivax plasmepsin V, putative 0.0259 0.082 0.2636
Onchocerca volvulus 0.003 0.0025 0.004
Loa Loa (eye worm) hypothetical protein 0.0071 0.0169 0.0436
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0011 0.0029
Brugia malayi hypothetical protein 0.0052 0.0103 0.0254
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Schistosoma mansoni zinc finger protein 0.0026 0.0011 0.0011
Loa Loa (eye worm) calpain family protein 1 0.0114 0.0317 0.0842
Mycobacterium tuberculosis Conserved protein 0.0071 0.0169 0.0366
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0169 0.0366
Echinococcus multilocularis acylamino acid releasing enzyme 0.0113 0.0312 0.0855
Loa Loa (eye worm) hypothetical protein 0.0071 0.0169 0.0436
Onchocerca volvulus 0.0071 0.0169 0.0436
Loa Loa (eye worm) hypothetical protein 0.0642 0.2151 0.5885
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0052 0.0114
Plasmodium vivax plasmepsin IV, putative 0.091 0.3082 1
Schistosoma mansoni hypothetical protein 0.0024 0.0003 0.0003
Schistosoma mansoni bromodomain containing protein 0.007 0.0164 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0169 0.0455
Loa Loa (eye worm) histone deacetylase 1 0.0484 0.1604 0.438
Echinococcus multilocularis histone deacetylase 0.0639 0.2141 0.5869
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.096 0.3257 1
Toxoplasma gondii kringle domain-containing protein 0.0075 0.0181 0.0469
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0259 0.082 0.2226
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0169 0.0465
Echinococcus granulosus Tolloid protein 1 0.0039 0.0057 0.0157
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.015 0.0412
Echinococcus granulosus BRCA1 associated protein 0.005 0.0094 0.0257
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0103 0.0254
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.005 0.0094 0.0564
Toxoplasma gondii histone deacetylase HDAC4 0.0256 0.081 0.2198
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0023 0.0033
Toxoplasma gondii histone deacetylase HDAC2 0.0484 0.1604 0.438
Loa Loa (eye worm) hypothetical protein 0.0113 0.0312 0.0828
Loa Loa (eye worm) hypothetical protein 0.0044 0.0074 0.0173
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0233 0.0732 0.1983
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0071 0.0184
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.0732 0.2006
Giardia lamblia Alanyl dipeptidyl peptidase 0.0113 0.0312 0.1676
Schistosoma mansoni brca1-associated protein (brap2) 0.005 0.0094 0.0094
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0113 0.0312 0.0846
Brugia malayi Fibulin-1 precursor 0.0039 0.0057 0.0128
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0427 0.1403 0.3841
Plasmodium vivax aspartyl protease, putative 0.0663 0.2226 0.7212
Plasmodium vivax importin-beta 2, putative 0.0029 0.0023 0.0039
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0095 0.0252 0.0808
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0169 0.0366
Entamoeba histolytica prolyl oligopeptidase family protein 0.0113 0.0312 0.1928
Toxoplasma gondii histone deacetylase HDAC3 0.0484 0.1604 0.438
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.016 0.0429
Brugia malayi Histone deacetylase family protein 0.0639 0.2141 0.5857
Leishmania major cathepsin L-like protease 0.0069 0.016 0.0429
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0011 0.0029
Brugia malayi hypothetical protein 0.0233 0.0732 0.1983
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0484 0.1604 0.5199
Mycobacterium tuberculosis Conserved protein 0.0071 0.0169 0.0366
Onchocerca volvulus 0.0087 0.0223 0.0583
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0025 0.0025
Echinococcus granulosus calpain 7 C02 family 0.0043 0.0071 0.0193
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0169 0.0366
Echinococcus granulosus importin subunit beta 1 0.0029 0.0023 0.0063
Loa Loa (eye worm) hypothetical protein 0.1073 0.3648 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0169 0.0507
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0071 0.0184
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0322 0.0857
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0043 0.0071 0.0184
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0095 0.0252 0.0808
Echinococcus multilocularis BRCA1 associated protein 0.005 0.0094 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Toxoplasma gondii histone deacetylase HDAC1 0.0639 0.2141 0.5857
Entamoeba histolytica prolyl oligopeptidase family protein 0.0113 0.0312 0.1928
Echinococcus multilocularis histone deacetylase 6 0.0639 0.2141 0.5869
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0849 0.2869 0.7859
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0103 0.0274
Schistosoma mansoni histone deacetylase 0.0484 0.1604 0.1604
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.005 0.0094 0.0271
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.005 0.0094 0.0094
Toxoplasma gondii ABC1 family protein 0.0071 0.0169 0.0436
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0071 0.0164
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0322 0.1036
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0169 0.0539
Loa Loa (eye worm) hypothetical protein 0.0075 0.0181 0.0469
Echinococcus granulosus histone deacetylase 8 0.0256 0.081 0.2221
Loa Loa (eye worm) hypothetical protein 0.0642 0.2151 0.5885
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.059 0.1593
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.1508 0.4541
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0011 0.0029
Echinococcus granulosus glycoprotein Antigen 5 0.003 0.0025 0.0069
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0011 0.0011
Mycobacterium ulcerans beta-lactamase 0.0071 0.0169 0.0507
Brugia malayi aspartic protease BmAsp-1, identical 0.0259 0.082 0.2226
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0427 0.1403 0.4845
Schistosoma mansoni hypothetical protein 0.0221 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0117 0.0327 0.0869
Schistosoma mansoni importin beta-1 0.0029 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.0069 0.016 0.0429
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0169 0.0366
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0849 0.2869 0.2869
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.091 0.3082 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0428 0.1409 0.1409
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0011 0.002
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.005 0.0094 0.0229
Schistosoma mansoni hypothetical protein 0.0221 0.0691 0.0691
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0095 0.0252 0.1555
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.005 0.0094 0.0257
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0113 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0849 0.2869 0.7859
Echinococcus granulosus laminin 0.0039 0.0057 0.0157
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0071 0.0184
Toxoplasma gondii aspartyl protease 0.0259 0.082 0.2226
Brugia malayi Eukaryotic aspartyl protease family protein 0.0259 0.082 0.2226
Loa Loa (eye worm) hypothetical protein 0.0052 0.0103 0.0254
Loa Loa (eye worm) hypothetical protein 0.0627 0.21 0.5744
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0322 0.0875
Leishmania major hypothetical protein, conserved 0.0052 0.0103 0.0274
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0095 0.0252 0.0665
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0208
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.004
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0095 0.0252 0.1291
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0011 0.0011
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.1604 0.5199
Trypanosoma brucei histone deacetylase 2 0.0256 0.081 0.2198
Leishmania major hypothetical protein, conserved 0.005 0.0094 0.0248
Trypanosoma brucei histone deacetylase, putative 0.0639 0.2141 0.5857
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.005 0.0094 0.0229
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0095 0.0252 0.0252
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.091 0.3082 0.8448
Plasmodium vivax histone deacetylase 1, putative 0.0484 0.1604 0.5187
Trypanosoma cruzi histone deacetylase, putative 0.0256 0.081 0.2213
Echinococcus granulosus endothelin converting enzyme 1 0.0849 0.2869 0.7865
Schistosoma mansoni cpg binding protein 0.0028 0.0019 0.0019
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0113 0.0312 0.0855
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0052 0.0133
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1073 0.3648 0.3648
Schistosoma mansoni egf-like domain protein 0.0039 0.0057 0.0057
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0011 0.0045
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0011 0.0045
Leishmania major eukaryotic initiation factor 4a, putative 0.0095 0.0252 0.0683
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Brugia malayi Inositol-1 0.0115 0.0322 0.0857
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0427 0.1403 0.3841
Schistosoma mansoni hypothetical protein 0.0221 0.0691 0.0691
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.005 0.0094 0.0293
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0011 0.0029
Plasmodium falciparum plasmepsin IV 0.091 0.3082 1
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0207 0.0639 0.0639
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0428 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.091 0.3082 0.8443
Brugia malayi histone deacetylase 1 (HD1) 0.0484 0.1604 0.438
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0207 0.0639 0.0639
Schistosoma mansoni hypothetical protein 0.0048 0.0087 0.0087
Echinococcus granulosus histone deacetylase 1 0.0484 0.1604 0.4397
Loa Loa (eye worm) hypothetical protein 0.0259 0.082 0.2226
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0312 0.0846
Schistosoma mansoni histone deacetylase 4 5 0.0639 0.2141 0.2141
Loa Loa (eye worm) hypothetical protein 0.0642 0.2151 0.5885
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0103 0.0274
Loa Loa (eye worm) peptidase family M13 containing protein 0.0627 0.21 0.5744
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.016 0.0429
Echinococcus multilocularis prolyl endopeptidase 0.1073 0.3648 1
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0103 0.0301
Schistosoma mansoni calpain C (C02 family) 0.0043 0.0071 0.0071
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0113 0.0312 0.1002
Toxoplasma gondii peptidase family M13 protein 0.0849 0.2869 0.7859
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0207 0.0639 0.0639
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0169 0.0436
Plasmodium vivax histone deacetylase 2, putative 0.0639 0.2141 0.6936
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0427 0.1403 0.3841
Schistosoma mansoni calpain (C02 family) 0.0043 0.0071 0.0071
Plasmodium vivax aspartyl proteinase, putative 0.091 0.3082 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0071 0.0164
Echinococcus granulosus histone deacetylase 6 0.0639 0.2141 0.5869
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0025 0.0025
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0427 0.1403 0.457
Schistosoma mansoni Mername-AA248 (C02 family) 0.0043 0.0071 0.0071
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.005 0.0094 0.0229
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0011 0.0029
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0011 0.002
Mycobacterium ulcerans hypothetical protein 0.0071 0.0169 0.0507
Leishmania major hypothetical protein, conserved 0.0026 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0117 0.0327 0.0869
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0113 0.0312 0.0855
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0095 0.0252 0.0692
Trypanosoma cruzi kinesin, putative 0.003 0.0026 0.0061
Trypanosoma cruzi histone deacetylase, putative 0.0639 0.2141 0.5865
Echinococcus multilocularis geminin 0.0175 0.0531 0.1454
Brugia malayi peptidase family M13 containing protein 0.0207 0.0639 0.1728
Loa Loa (eye worm) hypothetical protein 0.0627 0.21 0.5744
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.004
Brugia malayi prolyl oligopeptidase family protein 0.1073 0.3648 1
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.1604 0.5199
Loa Loa (eye worm) hypothetical protein 0.0642 0.2151 0.5885
Echinococcus granulosus calpain A 0.0043 0.0071 0.0193
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0484 0.1604 0.5199
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.005 0.0094 0.0293
Giardia lamblia Hypothetical protein 0.005 0.0094 0.027
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.005 0.0094 0.0094
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0052 0.0134
Echinococcus granulosus eukaryotic initiation factor 4A 0.0095 0.0252 0.0692
Plasmodium falciparum histone deacetylase 2 0.0639 0.2141 0.6936
Trypanosoma cruzi histone deacetylase 1, putative 0.0484 0.1604 0.4391
Leishmania major hypothetical protein, conserved 0.0075 0.0181 0.0488
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0052 0.0157
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0057 0.0128
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0207 0.0639 0.0639
Brugia malayi Importin beta-1 subunit 0.0029 0.0023 0.0033
Brugia malayi hypothetical protein 0.0259 0.082 0.2226
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0128
Loa Loa (eye worm) trypsin family protein 0.003 0.0025 0.004
Toxoplasma gondii calcium binding egf domain-containing protein 0.0039 0.0057 0.0128
Echinococcus granulosus histone deacetylase 6 0.0639 0.2141 0.5869
Trypanosoma cruzi histone deacetylase, putative 0.0639 0.2141 0.5865
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.0335 0.0335
Loa Loa (eye worm) histone deacetylase 11 0.0256 0.081 0.2198
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.015 0.0412
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.091 0.3082 0.3082
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0207 0.0639 0.0639
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0023 0.0063
Echinococcus granulosus Dipeptidyl peptidase 9 0.0113 0.0312 0.0855
Loa Loa (eye worm) hypothetical protein 0.0383 0.1252 0.3413
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0071 0.0164
Onchocerca volvulus 0.0071 0.0169 0.0436
Schistosoma mansoni inositol monophosphatase 0.0115 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0041 0.0065 0.0149
Toxoplasma gondii prolyl endopeptidase 0.1073 0.3648 1
Onchocerca volvulus 0.0048 0.0087 0.0208
Plasmodium falciparum histone deacetylase, putative 0.0639 0.2141 0.6936
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0039 0.0057 0.0057
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.0312 0.0828
Leishmania major oligopeptidase b 0.0427 0.1403 0.3841
Schistosoma mansoni histone deacetylase 0.0484 0.1604 0.1604
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0103 0.028 0.0411
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.003 0.0025 0.0025
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0164
Brugia malayi Trypsin-like protease protein 5 0.003 0.0025 0.004
Loa Loa (eye worm) aspartyl protease 6 0.0259 0.082 0.2226
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.0838 0.2297
Leishmania major histone deacetylase, putative 0.0639 0.2141 0.5865
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0184
Toxoplasma gondii aspartyl protease ASP1 0.091 0.3082 0.8443
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0115 0.0322 0.1045
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.003 0.0025 0.0069
Echinococcus granulosus calpain A 0.0119 0.0335 0.0919
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0071 0.0184
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0113 0.0312 0.0846
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0071 0.0184
Echinococcus multilocularis histone deacetylase 8 0.0256 0.081 0.2221
Echinococcus granulosus histone deacetylase 6 0.0689 0.2314 0.6342
Trypanosoma brucei histone deacetylase 1 0.0484 0.1604 0.438
Schistosoma mansoni hypothetical protein 0.0221 0.0691 0.0691
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0169 0.0366
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.005 0.0094 0.0271
Echinococcus multilocularis histone deacetylase 7 0.0639 0.2141 0.5869
Echinococcus multilocularis calpain 7 (C02 family) 0.0043 0.0071 0.0193
Loa Loa (eye worm) histone deacetylase 7A 0.0639 0.2141 0.5857
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0052 0.0157
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0011 0.0029
Onchocerca volvulus 0.0259 0.082 0.2226
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0011 0.0023
Echinococcus multilocularis calpain family protein 1, d 0.0084 0.0213 0.0583
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.005 0.0094 0.0271
Mycobacterium tuberculosis Conserved protein 0.0071 0.0169 0.0366
Echinococcus multilocularis Mastin 0.003 0.0025 0.0069
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.005 0.0094 0.027
Schistosoma mansoni hypothetical protein 0.0221 0.0691 0.0691
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.1604 0.5199
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.003 0.0025 0.004
Loa Loa (eye worm) hypothetical protein 0.0642 0.2151 0.5885
Schistosoma mansoni histone deacetylase hda2 0.0689 0.2314 0.2314
Loa Loa (eye worm) hypothetical protein 0.0039 0.0057 0.0128
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0011 0.0011
Trypanosoma brucei histone deacetylase 3 0.0639 0.2141 0.5857
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0011 0.0029
Schistosoma mansoni endothelin-converting enzyme-related 0.0207 0.0639 0.0639
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0113 0.0312 0.0312
Trichomonas vaginalis esterase, putative 0.0071 0.0169 0.0539
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.059 0.1593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Loa Loa (eye worm) hypothetical protein 0.0433 0.1425 0.3888
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0052 0.0143
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0113 0.0312 0.0828
Trypanosoma brucei histone deacetylase 4 0.0639 0.2141 0.5857
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0119 0.0335 0.0919
Giardia lamblia Histone deacetylase 0.0484 0.1604 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0169 0.0539
Echinococcus multilocularis inositol monophosphatase 1 0.0115 0.0322 0.0884
Echinococcus granulosus inositol monophosphatase 1 0.0115 0.0322 0.0884
Echinococcus granulosus calpain 0.0043 0.0071 0.0193
Leishmania major glycerol uptake protein, putative 0.0026 0.0011 0.002
Trypanosoma cruzi histone deacetylase, putative 0.0256 0.081 0.2213
Brugia malayi Peptidase family M13 containing protein 0.0849 0.2869 0.7859
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0113 0.0312 0.0828
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.005 0.0094 0.0229
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0221 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0095 0.0252 0.0665
Loa Loa (eye worm) hypothetical protein 0.0071 0.0168 0.0432
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0109 0.0289
Schistosoma mansoni histone deacetylase 4 5 0.0639 0.2141 0.2141
Echinococcus multilocularis calpain 5 0.0043 0.0071 0.0193
Echinococcus multilocularis Tolloid protein 1 0.0039 0.0057 0.0157
Loa Loa (eye worm) hypothetical protein 0.0627 0.21 0.5744
Echinococcus granulosus Mastin 0.003 0.0025 0.0069
Brugia malayi histone deacetylase 11 0.0256 0.081 0.2198
Loa Loa (eye worm) hypothetical protein 0.0264 0.0838 0.2274
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.016 0.0429
Toxoplasma gondii UBA/TS-N domain-containing protein 0.005 0.0094 0.0229
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.005 0.0094 0.0271
Brugia malayi beta-lactamase 0.0071 0.0169 0.0436
Schistosoma mansoni memapsin-2 (A01 family) 0.0259 0.082 0.082
Loa Loa (eye worm) prolyl oligopeptidase 0.0113 0.0312 0.0828
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0113 0.0312 0.0312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.016 0.041
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0052 0.0114
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0427 0.1403 0.3828
Schistosoma mansoni hypothetical protein 0.0312 0.1006 0.1006
Echinococcus multilocularis calpain 0.0043 0.0071 0.0193
Trichomonas vaginalis BRCA1-associated protein, putative 0.005 0.0094 0.0293
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0025 0.0025
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0169 0.0366
Schistosoma mansoni cercarial elastase (S01 family) 0.003 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0627 0.21 0.5744
Echinococcus multilocularis transmembrane protease serine 3 0.003 0.0025 0.0069
Trypanosoma cruzi histone deacetylase, putative 0.0639 0.2141 0.5865
Trypanosoma brucei kinesin, putative 0.003 0.0026 0.0041
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0011 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0259 0.082 0.082
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.005 0.0094 0.0229

Activities

Activity type Activity value Assay description Source Reference
Delta HDL (functional) = 100 % Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats ChEMBL. 8632431
Delta HDL (functional) = 100 % Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats ChEMBL. 8632431
Delta TC (functional) = -42 % Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 50 mg/kg ChEMBL. 8632431
Delta TC (functional) = -42 % Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 50 mg/kg ChEMBL. 8632431
Delta TC (functional) = -25 % Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats ChEMBL. 8632431
Delta TC (functional) = -25 % Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats ChEMBL. 8632431
IC50 (binding) = 11.5 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431
IC50 (binding) = 11.5 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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