Detailed information for compound 274789

Basic information

Technical information
  • TDR Targets ID: 274789
  • Name: pyridin-3-ylmethyl N-[(2S)-1-oxo-1-[[(3S)-2-o xo-5-phenyl-1-(3-phenylpropylsulfanyl)pentan- 3-yl]amino]-3-phenylpropan-2-yl]carbamate
  • MW: 609.778 | Formula: C36H39N3O4S
  • H donors: 2 H acceptors: 4 LogP: 6.8 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H](C(=O)N[C@H](C(=O)CSCCCc1ccccc1)CCc1ccccc1)Cc1ccccc1)OCc1cccnc1
  • InChi: 1S/C36H39N3O4S/c40-34(27-44-23-11-19-28-12-4-1-5-13-28)32(21-20-29-14-6-2-7-15-29)38-35(41)33(24-30-16-8-3-9-17-30)39-36(42)43-26-31-18-10-22-37-25-31/h1-10,12-18,22,25,32-33H,11,19-21,23-24,26-27H2,(H,38,41)(H,39,42)/t32-,33-/m0/s1
  • InChiKey: VZRKGDOTBQOIIT-LQJZCPKCSA-N  


Substructure search Similarity search

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Synonyms

  • 3-pyridylmethyl N-[(1S)-1-benzyl-2-oxo-2-[[(1S)-2-oxo-1-phenethyl-3-(3-phenylpropylsulfanyl)propyl]amino]ethyl]carbamate
  • N-[(1S)-1-benzyl-2-oxo-2-[[(1S)-2-oxo-1-phenethyl-3-(3-phenylpropylthio)propyl]amino]ethyl]carbamic acid 3-pyridylmethyl ester
  • pyridin-3-ylmethyl N-[(2S)-1-oxo-1-[[(3S)-2-oxo-5-phenyl-1-(3-phenylpropylsulfanyl)pentan-3-yl]amino]-3-phenyl-propan-2-yl]carbamate
  • N-[(1S)-1-benzyl-2-keto-2-[[(1S)-2-keto-1-phenethyl-3-(3-phenylpropylthio)propyl]amino]ethyl]carbamic acid 3-pyridylmethyl ester
  • 3-pyridylmethyl N-[(1S)-2-oxo-2-[[(1S)-2-oxo-1-(2-phenylethyl)-3-(3-phenylpropylsulfanyl)propyl]amino]-1-(phenylmethyl)ethyl]carbamate
  • N-[(1S)-2-oxo-2-[[(1S)-2-oxo-1-(2-phenylethyl)-3-(3-phenylpropylthio)propyl]amino]-1-(phenylmethyl)ethyl]carbamic acid 3-pyridylmethyl ester
  • N-[(1S)-1-(benzyl)-2-keto-2-[[(1S)-2-keto-1-(2-phenylethyl)-3-(3-phenylpropylthio)propyl]amino]ethyl]carbamic acid 3-pyridylmethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis two pore calcium channel protein 2 0.0023 0.0046 0.0046
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0077 0.0092
Toxoplasma gondii cathepsin CPL 0.0052 0.0582 0.0994
Onchocerca volvulus 0.0052 0.0582 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0159 0.0159
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0046 0.0046
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0046 0.0155
Echinococcus multilocularis potassium large conductance calcium activated 0.0023 0.0046 0.0046
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1678 0.1678
Echinococcus granulosus General substrate transporter 0.0096 0.1388 0.1388
Schistosoma mansoni hypothetical protein 0.0041 0.0374 0.0374
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Brugia malayi Cathepsin L-like precursor 0.0052 0.0582 0.0582
Echinococcus multilocularis ryanodine receptor 44f 0.0023 0.0046 0.0046
Echinococcus granulosus cathepsin L cysteine protease 0.0029 0.0159 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Brugia malayi voltage-dependent calcium channel 0.0023 0.0046 0.0046
Schistosoma mansoni lipoxygenase 0.0087 0.1219 0.1219
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0023 0.0046 0.0046
Echinococcus granulosus shaker cognate 0.0023 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0052 0.0582 0.3377
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0159 0.162
Onchocerca volvulus 0.0023 0.0046 0.0787
Brugia malayi Cathepsin L-like precursor 0.0037 0.0293 0.0293
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0077 0.0092
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0293 0.1649
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0582 0.0582
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0582 0.0582
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0023 0.0046 0.0046
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0023 0.0046 0.0046
Brugia malayi Cathepsin L-like precursor 0.0052 0.0582 0.0582
Schistosoma mansoni voltage-dependent calcium channel 0.0023 0.0046 0.0046
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0248 0.0248
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0235 0.0235
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1678 0.1678
Echinococcus granulosus potassium large conductance calcium activated 0.0023 0.0046 0.0046
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0046 0.0046
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0256 0.1423
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Brugia malayi Cathepsin L-like precursor 0.0052 0.0582 0.0582
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.1909 0.1909
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0716 0.0716
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0041 0.0374 0.4232
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0041 0.0374 0.0995
Brugia malayi Cyclic-nucleotide gated cation channel 0.0023 0.0046 0.0046
Trypanosoma brucei glucose transporter 1E 0.0035 0.0256 0.0637
Echinococcus multilocularis cathepsin b 0.0175 0.2847 0.2847
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0582 0.0582
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0023 0.0046 0.0046
Loa Loa (eye worm) cytochrome P450 0.0041 0.0374 0.0374
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0209 0.0209
Trypanosoma cruzi hexose transporter 0.0035 0.0256 0.0637
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0023 0.0046 0.0046
Toxoplasma gondii hypothetical protein 0.0056 0.0659 0.1137
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0077 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0041 0.0374 0.475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.078 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0041 0.0374 0.475
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0235 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Brugia malayi Cathepsin L-like precursor 0.0037 0.0293 0.0293
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0041 0.0374 0.4232
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.078 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0041 0.0374 0.4232
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.1909 0.1909
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0077 0.0077
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0374 0.0374
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0041 0.0374 0.475
Plasmodium falciparum protein kinase 6 0.0473 0.8364 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0256 0.0637
Plasmodium vivax vivapain-2 0.0052 0.0582 0.0696
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0023 0.0046 0.0046
Echinococcus multilocularis cysteine protease 0.0052 0.0582 0.0582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Leishmania major cathepsin L-like protease 0.0109 0.1634 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0248 0.0248
Toxoplasma gondii cathepsin B 0.0063 0.0791 0.1381
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0374 0.4232
Brugia malayi ion channel NompC 0.0023 0.0046 0.0046
Echinococcus granulosus two pore calcium channel protein 2 0.0023 0.0046 0.0046
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0046 0.0046
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0046 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.078 1
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) sugar transporter 0.0111 0.1678 0.1678
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0248 0.0297
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0046 0.0046
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0202 0.3347 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Leishmania major cytochrome p450-like protein 0.0041 0.0374 0.207
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0041 0.0374 0.4232
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Brugia malayi Cathepsin L-like precursor 0.0052 0.0582 0.0582
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0046 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0582 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1678 1
Brugia malayi cathepsin L-like precursor 0.0037 0.0293 0.0293
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.078 0.078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0041 0.0374 0.475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0159 0.0836
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0023 0.0046 0.0046
Schistosoma mansoni 60S ribosomal protein L21 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0561 1 1
Schistosoma mansoni voltage-gated ion channel 0.0023 0.0046 0.0046
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1678 0.1678
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0023 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0052 0.0582 0.3377
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0023 0.0046 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0041 0.0374 0.475
Schistosoma mansoni hypothetical protein 0.0111 0.1678 0.1678
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0582 0.0582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0159 0.0342
Loa Loa (eye worm) voltage-gated calcium channel 0.0023 0.0046 0.0046
Plasmodium vivax CDK-related protein kinase 6, putative 0.0473 0.8364 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0561 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0023 0.0046 0.0046
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0256 0.0637
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.2847 0.2847
Giardia lamblia Cathepsin B precursor 0.0063 0.0791 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0041 0.0374 0.4232
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0046 0.0046
Schistosoma mansoni transient receptor potential channel 0.0023 0.0046 0.0046
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1678 0.1678
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0041 0.0374 0.475
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0582 0.1624
Toxoplasma gondii facilitative glucose transporter GT1 0.0111 0.1678 0.3026
Loa Loa (eye worm) cathepsin B 0.0063 0.0791 0.0791
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0093 0.1345 0.3935
Schistosoma mansoni glucose transport protein 0.0111 0.1678 0.1678
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0023 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0041 0.0374 0.4232
Echinococcus multilocularis General substrate transporter 0.0096 0.1388 0.1388
Echinococcus multilocularis voltage dependent calcium channel 0.0561 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.078 1
Mycobacterium leprae putative cytochrome p450 0.0041 0.0374 1
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0248 0.1374
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0041 0.0374 0.4232
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.1634 0.481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Echinococcus multilocularis transient receptor potential gamma protein 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Echinococcus granulosus cathepsin L 0.0029 0.0159 0.0159
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0046 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0111 0.1678 0.1678
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0582 0.0582
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0046 0.0046
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.008 0.1088 0.1088
Mycobacterium leprae Conserved hypothetical protein 0.0041 0.0374 1
Toxoplasma gondii transporter, cation channel family protein 0.008 0.1088 0.1933
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0023 0.0046 0.0046
Echinococcus multilocularis conserved hypothetical protein 0.0023 0.0046 0.0046
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0256 0.0637
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0046 0.0046
Echinococcus granulosus cathepsin b 0.0175 0.2847 0.2847
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0338 0.1837
Brugia malayi Cathepsin L-like precursor 0.0052 0.0582 0.0582
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Echinococcus granulosus cathepsin l1 0.0052 0.0582 0.0582
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0041 0.0374 0.4232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0561 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0046 0.0046
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0041 0.0374 0.4232
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.018 0.2947 0.3524
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Schistosoma mansoni voltage-gated cation channel 0.0561 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0041 0.0374 0.475
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0077 0.189
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0046 0.0046
Entamoeba histolytica protein kinase, putative 0.0034 0.0248 0.3386
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.4118 0.4118
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0582 0.0582
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0716 0.9086
Echinococcus granulosus cathepsin l1 0.0037 0.0293 0.0293
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0145 0.2305 0.2305
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0111 0.1678 0.1678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Loa Loa (eye worm) hypothetical protein 0.0056 0.0659 0.0659
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0041 0.0374 0.4232
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0046 0.0046
Plasmodium vivax vivapain-3 0.0029 0.0159 0.019
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0248 0.0248
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0159 0.0159
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0374 0.0995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0175 0.2847 0.8486
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.0922 0.2653
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0046 0.0046
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Brugia malayi Sugar transporter family protein 0.0111 0.1678 0.1678
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0256 0.1423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.2847 0.2847
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0374 0.0374
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0041 0.0374 0.475
Loa Loa (eye worm) hypothetical protein 0.0027 0.0119 0.0119
Entamoeba histolytica cysteine proteinase 2 0.0029 0.0159 0.162
Brugia malayi cathepsin B-like cysteine proteinase 0.0175 0.2847 0.2847
Leishmania major cathepsin L-like protease 0.0052 0.0582 0.3377
Onchocerca volvulus 0.0052 0.0582 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0041 0.0374 0.475
Echinococcus granulosus cysteine protease 0.0029 0.0159 0.0159
Plasmodium vivax vivapain-2 0.0052 0.0582 0.0696
Brugia malayi Cytochrome P450 family protein 0.0121 0.1863 0.1863
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0248 0.0297
Trypanosoma brucei cysteine peptidase C (CPC) 0.0063 0.0791 0.2257
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0374 0.0374
Echinococcus multilocularis calcium activated potassium channel 0.0025 0.0085 0.0085
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0077 0.0342
Leishmania major cathepsin L-like protease 0.0109 0.1634 1
Schistosoma mansoni cytochrome P450 0.0041 0.0374 0.0374
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0293 0.1649
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0256 0.0637
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0023 0.0046 0.0046
Schistosoma mansoni ryanodine receptor related 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0041 0.0374 0.0995
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0248 0.0297
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0248 0.0297
Schistosoma mansoni transient receptor potential channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0033 0.0235 0.0235
Loa Loa (eye worm) calcium channel 0.0561 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.078 0.078
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0111 0.1678 0.1678
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0046 0.0046
Plasmodium falciparum mitogen-activated protein kinase 2 0.018 0.2947 0.3524
Plasmodium falciparum cysteine proteinase falcipain 1 0.0029 0.0159 0.019
Entamoeba histolytica cysteine proteinase 1, putative 0.0029 0.0159 0.162
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0046 0.0046
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0235 0.6203
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0041 0.0374 0.475
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0582 0.0696
Trypanosoma brucei glucose transporter 2A 0.0035 0.0256 0.0637
Plasmodium vivax unspecified product 0.0029 0.0159 0.019
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Plasmodium vivax vivapain-1 0.0029 0.0159 0.019
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0582 0.0696
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0023 0.0046 0.0046
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0041 0.0374 0.4232
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0077 0.0077
Schistosoma mansoni calcium-activated potassium channel 0.0023 0.0046 0.0046
Echinococcus granulosus voltage dependent calcium channel 0.008 0.1088 0.1088
Loa Loa (eye worm) hypothetical protein 0.0056 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0037 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0582 0.339
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0023 0.0046 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0046 0.0046
Echinococcus granulosus ryanodine receptor 44f 0.0023 0.0046 0.0046
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0023 0.0046 0.0046
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0023 0.0046 0.0046
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0716 0.4219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0561 1 1
Schistosoma mansoni protein kinase 0.0034 0.0248 0.0248
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0046 0.0046
Onchocerca volvulus 0.0052 0.0582 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0023 0.0046 0.0046
Plasmodium falciparum protein kinase 7 0.0315 0.5439 0.6504
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0046 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0582 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0041 0.0374 0.4232
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0248 0.0248
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0046 0.0046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 0.2847 0.2847
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0046 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0041 0.0374 0.475
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0256 0.1423
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0023 0.0046 0.0046
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0561 1 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0248 0.0375
Brugia malayi Transient-receptor-potential like protein 0.0023 0.0046 0.0046
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0561 1 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0041 0.0374 0.4232
Echinococcus granulosus transient receptor potential gamma protein 0.0023 0.0046 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0041 0.0374 0.475
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0582 0.0582
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0248 0.0248
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0582 0.0696
Leishmania major cytochrome p450-like protein 0.0041 0.0374 0.207
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Echinococcus multilocularis short transient receptor potential channel 6 0.0023 0.0046 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0338 0.0404
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0041 0.0374 0.4232
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0041 0.0374 0.207
Onchocerca volvulus 0.0052 0.0582 1
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.078 0.1361
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.0791 0.4649
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0023 0.0046 0.0046
Echinococcus granulosus cathepsin b 0.0175 0.2847 0.2847
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0561 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Entamoeba histolytica cysteine protease, putative 0.0052 0.0582 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0041 0.0374 0.475
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0077 0.0058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0159 0.0159
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0041 0.0374 0.475
Echinococcus granulosus sodium leak channel non selective protein 0.0023 0.0046 0.0046
Trypanosoma cruzi cruzipain precursor, putative 0.0109 0.1634 0.481
Leishmania major glucose transporter, lmgt2 0.0035 0.0256 0.1324
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0235 0.0235
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0293 0.4287
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0338 0.0404
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0041 0.0374 0.4232
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0235 0.3133
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0023 0.0046 0.0046
Loa Loa (eye worm) ion channel NompC 0.0023 0.0046 0.0046
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Schistosoma mansoni two-pore calcium channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.0121 0.1863 0.1863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.0791 0.4692
Giardia lamblia Cathepsin B precursor 0.0063 0.0791 1
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.1634 0.481
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0582
Echinococcus multilocularis sodium channel protein 0.0145 0.2305 0.2305
Toxoplasma gondii cytochrome p450 superfamily protein 0.0041 0.0374 0.0609
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.1634 0.481
Echinococcus multilocularis two pore calcium channel protein 1 0.0023 0.0046 0.0046
Leishmania major cytochrome p450-like protein 0.0041 0.0374 0.207
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0041 0.0374 0.475
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0159 0.0342
Schistosoma mansoni glucose transport protein 0.0111 0.1678 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0159 0.0836
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0046 0.0046
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0041 0.0374 0.0995
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0159 0.162
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0046 0.0046
Brugia malayi hypothetical protein 0.0023 0.0046 0.0046
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0248 0.0297
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0077 0.0195
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0175 0.2847 0.2847
Echinococcus multilocularis cysteine protease 0.0052 0.0582 0.0582
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0248 0.0248
Leishmania major cathepsin L-like protease 0.0109 0.1634 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Echinococcus multilocularis voltage dependent calcium channel 0.0561 1 1
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0256 0.0637
Loa Loa (eye worm) hypothetical protein 0.0033 0.0235 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0029 0.0159 0.0159
Leishmania major cathepsin L-like protease 0.0052 0.0582 0.3377
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0248 0.0375
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0716 0.9086
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0256 0.1423
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0041 0.0374 0.4232
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0561 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0582 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0256 0.1324
Schistosoma mansoni protein kinase 0.0034 0.0248 0.0248
Onchocerca volvulus 0.0052 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0023 0.0046 0.0046
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0077 0.0094
Echinococcus granulosus voltage dependent calcium channel 0.0561 1 1
Brugia malayi olfactory channel protein osm-9 0.0023 0.0046 0.0046
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0248 0.0297
Loa Loa (eye worm) cysteine protease 0.0052 0.0582 0.0582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0041 0.0374 0.475
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0582 0.0582
Brugia malayi Cytochrome P450 family protein 0.0041 0.0374 0.0374
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0248 0.0612
Brugia malayi Cytochrome P450 family protein 0.0041 0.0374 0.0374
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0256 0.0637
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0716 0.9168
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0046 0.0046
Echinococcus multilocularis sodium leak channel non selective protein 0.0023 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0052 0.0582 0.3377
Echinococcus granulosus hypothetical protein 0.0023 0.0046 0.0046
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0338 0.0884
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0175 0.2847 0.2847
Schistosoma mansoni transient receptor potential channel 4 0.0023 0.0046 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0046 0.0046
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0248 0.0248
Brugia malayi Cytochrome P450 family protein 0.0041 0.0374 0.0374
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0041 0.0374 0.475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Loa Loa (eye worm) hypothetical protein 0.0037 0.0293 0.0293
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0046 0.0046
Brugia malayi follicle stimulating hormone receptor 0.0243 0.4118 0.4118
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0046 0.0155
Brugia malayi Cathepsin L-like precursor 0.0052 0.0582 0.0582
Giardia lamblia Cathepsin B precursor 0.0063 0.0791 1
Trypanosoma cruzi cysteine protease, putative 0.0029 0.0159 0.0342
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0582 0.0582
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0041 0.0374 0.0995
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0256 0.1423
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0023 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0041 0.0374 0.4232
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0023 0.0046 0.0046
Echinococcus multilocularis cathepsin L 0.0029 0.0159 0.0159
Onchocerca volvulus 0.0037 0.0293 0.5041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.0791 0.0791
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) ctsf protein 0.0052 0.0582 0.0582
Schistosoma mansoni glucose transport protein 0.0111 0.1678 0.1678
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0023 0.0046 0.0046
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0046 0.0046
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0046 0.0046
Entamoeba histolytica protein kinase, putative 0.0034 0.0248 0.3386
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.078 0.078
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0338 0.0541
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0642 0.0642
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0582 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0046 0.0046
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0256 0.1423
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0716 0.0716
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0046 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0582 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0235 0.0235
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0023 0.0046 0.0046
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0046 0.0046
Echinococcus granulosus two pore calcium channel protein 1 0.0023 0.0046 0.0046
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0235 0.0235
Brugia malayi cation channel family protein 0.0023 0.0046 0.0046
Loa Loa (eye worm) fibroinase 0.0052 0.0582 0.0582
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0293 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0041 0.0374 0.4232
Echinococcus granulosus calcium activated potassium channel 0.0025 0.0085 0.0085
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0561 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0023 0.0046 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.078 0.078
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.0791 0.2257
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.018 0.2947 0.5379
Plasmodium vivax hexose transporter 0.0111 0.1678 0.2006
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0023 0.0046 0.0046
Toxoplasma gondii protein kinase, putative 0.0315 0.5439 1
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Onchocerca volvulus 0.0052 0.0582 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0046 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Echinococcus granulosus short transient receptor potential channel 6 0.0023 0.0046 0.0046
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0023 0.0046 0.0046
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0041 0.0374 0.475
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0248 0.0297
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0235 0.1297
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0023 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0041 0.0374 0.4232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0046 0.0046
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0046 0.0046
Leishmania major glucose transporter, lmgt3 0.0035 0.0256 0.1324
Brugia malayi cation channel family protein 0.0023 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0029 0.0159 0.0342
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Echinococcus granulosus sodium channel protein 0.0023 0.0046 0.0046
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0159 0.162
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0293 0.0293
Schistosoma mansoni vesicular amine transporter 0.0023 0.0046 0.0046
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0235 0.2217
Brugia malayi cytochrome P450 0.0041 0.0374 0.0374
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0023 0.0046 0.0046
Schistosoma mansoni protein kinase 0.0034 0.0248 0.0248
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.078 0.4624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0029 0.0159 0.0342
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0046 0.0046
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0046 0.0046
Leishmania major protein kinase, putative 0.0034 0.0248 0.1273
Trypanosoma brucei glucose transporter, putative 0.0035 0.0256 0.0637
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0023 0.0046 0.0046
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0046 0.0046
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0023 0.0046 0.0787
Echinococcus granulosus short transient receptor potential channel 6 0.0023 0.0046 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0023 0.0046 0.0046
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0716 0.0716
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0256 0.1423
Entamoeba histolytica cysteine protease, putative 0.0029 0.0159 0.162
Loa Loa (eye worm) hypothetical protein 0.0037 0.0293 0.0293
Plasmodium falciparum hexose transporter 0.0111 0.1678 0.2006
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0041 0.0374 0.475
Leishmania major glucose transporter, lmgt1 0.0035 0.0256 0.1324
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0338 0.1837
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0041 0.0374 0.475
Trypanosoma cruzi cysteine proteinase, putative 0.0029 0.0159 0.0342
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0023 0.0046 0.0046
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0374 0.0995
Echinococcus multilocularis 0.0041 0.0374 0.0374
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0077 0.5
Echinococcus multilocularis cathepsin b 0.0175 0.2847 0.2847
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) ryanodine receptor 0.0023 0.0046 0.0046
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0077 0.0077
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Loa Loa (eye worm) voltage-gated potassium channel 0.0023 0.0046 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0023 0.0046 0.0046
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0248 0.0297
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0248 0.0297
Onchocerca volvulus 0.0052 0.0582 1
Echinococcus multilocularis shaker cognate 0.0023 0.0046 0.0046
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0716 0.0716
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0046 0.0046
Schistosoma mansoni lipoxygenase 0.0124 0.1909 0.1909
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0582 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0338 0.0884
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0374 0.0995
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0561 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.008 0.1088 0.1088
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0041 0.0374 0.4232
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0202 0.3347 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0248 0.0375
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0248 0.0248
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0159 0.0159
Echinococcus granulosus voltage gated hydrogen channel 1 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0159 0.162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.1634 0.481
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0034 0.0248 0.0248
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0235 0.0235
Echinococcus granulosus TRP transient receptor potential channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0077
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0046 0.0046
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0582 0.3377
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0248 0.0248
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0582 0.0582
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0338 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0582 0.339
Echinococcus multilocularis transfer RNA-Gly 0.0023 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0582 0.339
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0159 0.0342
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0077 0.0094
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0023 0.0046 0.0046
Brugia malayi Cam kinase protein 1 0.0034 0.0248 0.0248
Schistosoma mansoni transient receptor potential channel 0.0023 0.0046 0.0046
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0023 0.0046 0.0046
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0046 0.0046
Echinococcus granulosus cytochrome P450 2K1 0.0041 0.0374 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0582 0.339

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.9 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 0.9 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 5.4 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 5.4 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 28.8 nM Inhibitory activity of the compound against human Cathepsin L ChEMBL. 11806719
Ki (binding) = 28.8 nM Inhibitory activity of the compound against human Cathepsin L ChEMBL. 11806719
Ki (binding) = 700 nM Inhibitory activity of the compound against human Cathepsin B ChEMBL. 11806719
Ki (binding) = 700 nM Inhibitory activity of the compound against human Cathepsin B ChEMBL. 11806719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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