Detailed information for compound 27911

Basic information

Technical information
  • TDR Targets ID: 27911
  • Name: 4-(imidazol-1-ylmethyl)-2-naphthalen-2-yloxyb enzonitrile
  • MW: 325.363 | Formula: C21H15N3O
  • H donors: 0 H acceptors: 2 LogP: 4.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1Oc1ccc2c(c1)cccc2)Cn1ccnc1
  • InChi: 1S/C21H15N3O/c22-13-19-6-5-16(14-24-10-9-23-15-24)11-21(19)25-20-8-7-17-3-1-2-4-18(17)12-20/h1-12,15H,14H2
  • InChiKey: BECWPNYJZIVGFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(imidazol-1-ylmethyl)-2-(2-naphthyloxy)benzonitrile
  • 4-(1-imidazolylmethyl)-2-(2-naphthalenyloxy)benzonitrile
  • 4-(imidazol-1-ylmethyl)-2-naphthalen-2-yloxy-benzenecarbonitrile
  • 4-(imidazol-1-ylmethyl)-2-(2-naphthoxy)benzonitrile
  • 4-(1-imidazolylmethyl)-2-(2-naphthyloxy)benzonitrile
  • 4-(imidazol-1-ylmethyl)-2-naphthalen-2-yloxy-benzonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References
Homo sapiens protein geranylgeranyltransferase type I, beta subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_129786 All targets in OG5_129786
Schistosoma japonicum ko:K05955 protein geranylgeranyltransferase type I, beta subunit [EC:2.5.1.59], putative Get druggable targets OG5_129786 All targets in OG5_129786
Schistosoma mansoni geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_129786 All targets in OG5_129786
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) Get druggable targets OG5_129786 All targets in OG5_129786
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative Get druggable targets OG5_129786 All targets in OG5_129786
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica geranylgeranyl transferase beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) Get druggable targets OG5_129786 All targets in OG5_129786
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni geranylgeranyl transferase type I beta subunit Get druggable targets OG5_129786 All targets in OG5_129786
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein farnesyltransferase beta subunit protein geranylgeranyltransferase type I, beta subunit 377 aa 361 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0008
Brugia malayi Cation transporter family protein 0.0626 0.8952 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0583 0.1637
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0177 0.0154
Schistosoma mansoni hypothetical protein 0.0171 0.2329 0.231
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0377 0.1011
Leishmania major farnesyltransferase beta subunit 0.0036 0.0364 0.471
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0096 0.0156
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.2642 0.79
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0114 0.0114
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.005 0.056 0.0609
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0626 0.8952 0.8952
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0073 0.0175
Brugia malayi SET domain containing protein 0.0013 0.0025 0.0018
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0377 0.0354
Schistosoma mansoni survival motor neuron protein 0.0049 0.0543 0.052
Brugia malayi Pre-SET motif family protein 0.0031 0.0281 0.0304
Echinococcus granulosus tumor protein p63 0.0342 0.4811 0.4811
Brugia malayi PXA domain containing protein 0.0019 0.0114 0.0118
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.017 0.0171
Onchocerca volvulus 0.0626 0.8952 1
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0175 0.2376 0.2653
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0121 0.0121
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0048 0.0533 0.0578
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.1156 0.1135
Schistosoma mansoni acetylcholine receptor-related 0.0289 0.4039 0.4024
Schistosoma mansoni nAChR subunit 0.0626 0.8952 0.8949
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0626 0.8952 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0677 0.0655
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0626 0.8952 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0529 0.0573
Schistosoma mansoni nAChR subunit 0.0626 0.8952 0.8949
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0193 0.2642 0.5458
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0193 0.2642 0.2944
Schistosoma mansoni cpg binding protein 0.0031 0.0279 0.0256
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0121 0.0125
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0177 0.0582
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0114 0.0091
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.017 0.0147
Schistosoma mansoni CREB-binding protein 2 0.0103 0.1325 0.1304
Brugia malayi Thioredoxin reductase 0.0048 0.0529 0.0581
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.024 0.3332 0.6949
Schistosoma mansoni nAChR subunit 0.0626 0.8952 0.8949
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0114 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.005 0.056 0.9588
Trypanosoma brucei protein kinase, putative 0.0052 0.0583 1
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0193 0.2642 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0121 0.0117
Onchocerca volvulus 0.0102 0.1324 0.1255
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.0389
Onchocerca volvulus 0.005 0.0561 0.038
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0114 0.0091
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1421 0.1568
Echinococcus multilocularis CREB binding protein 0.0017 0.0077 0.0077
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0337 0.4745 0.5296
Echinococcus multilocularis CREB binding protein 0.0017 0.0077 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0606
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0036 0.0364 0.1726
Schistosoma mansoni nAChR subunit 0.0626 0.8952 0.8949
Echinococcus granulosus glycine receptor subunit alpha 1 0.0626 0.8952 0.8952
Echinococcus granulosus glycine receptor subunit alpha 1 0.0626 0.8952 0.8952
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0583 0.7903
Loa Loa (eye worm) acetylcholine receptor protein 0.0289 0.4039 0.4502
Echinococcus multilocularis nAChR subunit 0.0626 0.8952 0.8952
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0626 0.8952 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0626 0.8952 0.8952
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0024 0.0009
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0677 0.0747
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0114 0.0091
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0626 0.8952 0.8952
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0626 0.8952 0.8952
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0289 0.4039 0.4039
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0377 0.4902
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0449 0.0426
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0114 0.0114
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0626 0.8952 0.8952
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0529 0.1773
Brugia malayi hypothetical protein 0.0289 0.4039 0.4506
Echinococcus granulosus neuropeptide s receptor 0.0472 0.6704 0.6704
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0121 0.0117
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0024 0.0024
Brugia malayi cytochrome P450 0.0014 0.0041 0.0035
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0626 0.8952 0.8949
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0036 0.0364 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0114 0.0213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0606
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0121 0.0121
Echinococcus granulosus glycine receptor subunit beta 0.0626 0.8952 0.8952
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2908 0.3236
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0193 0.2642 0.79
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0727 0.0779
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.0238
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Schistosoma mansoni hypothetical protein 0.0014 0.0041 0.0016
Onchocerca volvulus 0.0289 0.4039 0.4367
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.2642 0.79
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0193 0.2642 0.2938
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0096 0.0156
Entamoeba histolytica hypothetical protein 0.0337 0.4745 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0529 0.0529
Brugia malayi PXA domain containing protein 0.0019 0.0114 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0121 0.0097
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.1057 0.1035
Trypanosoma cruzi protein farnesyltransferase, putative 0.0036 0.0364 0.596
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0626 0.8952 0.8952
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0114 0.0114
Plasmodium vivax geranylgeranyltransferase, putative 0.0036 0.0364 0.113
Brugia malayi Cation transporter family protein 0.0626 0.8952 1
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Brugia malayi hypothetical protein 0.0289 0.4039 0.4506
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0583 0.7903
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0606
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0045 0.004
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0114 0.0118
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.005 0.056 0.1896
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0073 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0114 0.0213
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0626 0.8952 0.8952
Brugia malayi Cytochrome P450 family protein 0.0014 0.0041 0.0035
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0036 0.0364 0.0971
Onchocerca volvulus 0.0042 0.0449 0.0252
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0377 0.0377
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.005 0.056 0.9588
Schistosoma mansoni neurotransmitter gated ion channel 0.0289 0.4039 0.4024
Onchocerca volvulus 0.0029 0.0255 0.003
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0036 0.0364 0.113
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0096 0.0156
Brugia malayi hypothetical protein 0.0019 0.0114 0.0118
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0727 0.0779
Trypanosoma brucei cytochrome P450, putative 0.0023 0.017 0.2381
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0229 0.0238
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.6704 0.6704
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0364 0.596
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3316 0.3316
Echinococcus multilocularis 0.0014 0.0041 0.0041
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0337 0.4745 0.4732
Loa Loa (eye worm) CYP4Cod1 0.0023 0.017 0.0171
Leishmania major cytochrome p450-like protein 0.0023 0.017 0.1882
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0177 0.0726
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0626 0.8952 0.8952
Brugia malayi glutathione reductase 0.0048 0.0529 0.0581
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.011
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0114 0.0118
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0049 0.0543 0.052
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0377 0.0377
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0177 0.0401
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0626 0.8952 0.8952
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0073 0.0037
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Loa Loa (eye worm) LGC-31 protein 0.0626 0.8952 1
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Leishmania major trypanothione reductase 0.0048 0.0529 0.7115
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0626 0.8952 0.8952
Echinococcus granulosus nAChR subunit 0.0626 0.8952 0.8952
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.017 0.2381
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0583 0.2895
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0073 0.0072
Plasmodium vivax SET domain protein, putative 0.0031 0.0281 0.0809
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.1057 0.1057
Schistosoma mansoni intermediate filament proteins 0.0027 0.0229 0.0206
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0073 0.0606
Echinococcus multilocularis glycine receptor subunit beta 0.0626 0.8952 0.8952
Brugia malayi TAZ zinc finger family protein 0.0103 0.1325 0.1472
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0289 0.4039 0.4502
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0626 0.8952 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0114 0.0118
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0626 0.8952 1
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0606
Echinococcus multilocularis thymidine phosphorylase 0.0619 0.8846 0.8846
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3316 0.3316
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0193 0.2642 1
Brugia malayi intermediate filament protein 0.0027 0.0229 0.0246
Onchocerca volvulus 0.0049 0.0543 0.0359
Loa Loa (eye worm) CBP-B 0.0071 0.0869 0.0954
Loa Loa (eye worm) ACC-1 protein 0.0626 0.8952 1
Echinococcus granulosus protein prenyltransferase alpha subunit 0.005 0.056 0.056
Loa Loa (eye worm) ACC-1 protein 0.0626 0.8952 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0626 0.8952 0.8952
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1324 0.1464
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0364 0.596
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.005 0.056 0.0963
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0626 0.8952 0.8949
Loa Loa (eye worm) hypothetical protein 0.0037 0.0377 0.0403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0677 0.0723
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0256 0.0256
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0543 0.0596
Schistosoma mansoni neurotransmitter gated ion channel 0.0289 0.4039 0.4024
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.005 0.056 0.0616
Onchocerca volvulus 0.0337 0.4745 0.5177
Loa Loa (eye worm) GABA receptor subunit 0.0337 0.4745 0.5292
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0377 0.0567
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0377 0.6202
Brugia malayi CHD4 protein 0.0013 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0045 0.0032
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0583 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.1057 0.1165
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0036 0.0364 0.0971
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0036 0.0364 0.034
Echinococcus granulosus glycine receptor subunit beta 0.0626 0.8952 0.8952
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0036 0.0364 0.113
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0337 0.4745 0.5296
Trypanosoma cruzi lanosterol synthase, putative 0.0036 0.0364 0.596
Echinococcus granulosus CREB binding protein 0.0017 0.0077 0.0077
Giardia lamblia Rab geranylgeranyltransferase 0.0193 0.2642 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0529 0.0529
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0036 0.0364 0.0538
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0289 0.4039 0.4039
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0561 0.0538
Echinococcus multilocularis nAChR subunit 0.0337 0.4745 0.4745
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0036 0.0364 0.113
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0626 0.8952 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0073 0.0606
Loa Loa (eye worm) hypothetical protein 0.0239 0.3316 0.3693
Brugia malayi hypothetical protein 0.0102 0.1324 0.147
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.024 0.3332 0.3716
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0114 0.0213
Schistosoma mansoni hypothetical protein 0.0171 0.2329 0.231
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.024 0.3332 0.3332
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0036 0.0364 0.0364
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0289 0.4039 0.4502
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0036 0.0364 0.0364
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.005 0.056 0.056
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0337 0.4745 0.5296
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0114 0.0213
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0377 0.0377
Onchocerca volvulus 0.005 0.056 0.038
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0041 0.0041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0337 0.4745 0.5296
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0583 0.1637
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0073 0.0606
Loa Loa (eye worm) cytochrome P450 0.0014 0.0041 0.0027
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0114 0.0114
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0114 0.0114
Onchocerca volvulus 0.0084 0.1057 0.0949
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0583 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1599 0.667
Loa Loa (eye worm) glutathione reductase 0.0048 0.0529 0.0573
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.1057 0.1172
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0073 0.0606
Echinococcus granulosus geminin 0.0171 0.2329 0.2329
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Brugia malayi MAP kinase sur-1 0.0052 0.0583 0.0641
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0364 0.0971
Schistosoma mansoni lamin 0.0027 0.0229 0.0206
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0281 0.1284
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.024 0.3332 0.3332
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0051 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0698 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0281 0.0281
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0677 0.0723
Brugia malayi Cytochrome P450 family protein 0.0023 0.017 0.0179
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0073 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0677 0.0723
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0177 0.1982
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0036 0.0364 0.596
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0114 0.011
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.6704 0.6704
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.024 0.3332 0.3711
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0114 0.0114
Brugia malayi hypothetical protein 0.0239 0.3316 0.3698
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.056 0.9588
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0232
Brugia malayi excitatory GABA receptor EXP-1A 0.0626 0.8952 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.024 0.3332 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1421 0.1568
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0114 0.0114
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0036 0.0364 0.034
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0377 0.0411
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0727 0.0727
Entamoeba histolytica hypothetical protein 0.0024 0.0177 0.0134
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0377 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0051 0.0021
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0177 1
Echinococcus granulosus cpg binding protein 0.0031 0.0279 0.0279
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0606
Schistosoma mansoni nAChR subunit 0.0626 0.8952 0.8949
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0626 0.8952 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0114 0.0114
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0114 0.0114
Plasmodium falciparum glutathione reductase 0.0048 0.0529 0.1773
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0377 0.1182
Brugia malayi hypothetical protein 0.0289 0.4039 0.4506
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0121 0.0097
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0229 0.0238
Echinococcus multilocularis geminin 0.0171 0.2329 0.2329
Echinococcus granulosus CREB binding protein 0.0017 0.0077 0.0077
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0177 0.0154
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0583 0.1983
Echinococcus granulosus nAChR subunit 0.0337 0.4745 0.4745
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0177 1
Echinococcus granulosus dnaJ subfamily B 0.0414 0.5859 0.5859
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0364 0.596
Echinococcus multilocularis expressed protein 0.0378 0.5332 0.5332
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.4039 0.4506
Onchocerca volvulus 0.024 0.3331 0.3556
Giardia lamblia Prenyltransferase 0.0036 0.0364 0.113
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0114 0.0091
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0583 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.024 0.3332 0.3316
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0036 0.0364 0.0538
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0175 0.2376 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0024 0.0024
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1599 0.1769
Echinococcus granulosus lamin 0.0027 0.0229 0.0229
Brugia malayi CXXC zinc finger family protein 0.0029 0.0255 0.0275
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0036 0.0364 0.0367
Trypanosoma brucei trypanothione reductase 0.0048 0.0529 0.9003
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0036 0.0364 0.0364
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0073 0.0479
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.005 0.056 0.9588
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0626 0.8952 1
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0175 0.2376 0.2653
Brugia malayi hypothetical protein 0.0019 0.0114 0.0118
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0036 0.0364 0.1726
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0626 0.8952 0.8952
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0364 0.0971
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.005 0.056 0.056
Leishmania major protein farnesyltransferase alpha subunit, putative 0.005 0.056 0.7577
Schistosoma mansoni hypothetical protein 0.0414 0.5859 0.5849
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Brugia malayi follicle stimulating hormone receptor 0.0239 0.3315 0.3696
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0377 0.6202
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.4039 0.4506
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1421 0.1568
Onchocerca volvulus 0.0626 0.8952 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1421 0.5911
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0377 0.1011
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0626 0.8952 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0096 0.0156
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0377 0.0377
Trypanosoma brucei lanosterol synthase 0.0036 0.0364 0.596
Echinococcus granulosus CREB binding protein 0.0103 0.1325 0.1325
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0377 0.1011
Plasmodium vivax glutathione reductase, putative 0.0048 0.0529 0.1773
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0364 0.0971
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0073 0.0073
Onchocerca volvulus 0.0102 0.1324 0.1255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.4039 0.4506
Echinococcus multilocularis glycine receptor subunit beta 0.0626 0.8952 0.8952
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0583 0.1637
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0096 0.0156
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0114 0.0091
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0114 0.0114
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0626 0.8952 0.8949
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.0389
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0583 0.056
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.1913 0.5684
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0626 0.8952 0.8952
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0626 0.8952 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0583 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1421 0.1568
Trichomonas vaginalis set domain proteins, putative 0.024 0.3331 0.9998
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0036 0.0364 0.0971
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0479
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.011
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0027 0.0222 0.023
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0193 0.2642 0.2642
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0177 0.0401
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0626 0.8952 0.8952
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.005 0.056 0.056
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.1324 0.147
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0289 0.4039 0.4039
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0114 0.0091
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0103 0.1325 0.1304
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0626 0.8952 1
Plasmodium falciparum thioredoxin reductase 0.0048 0.0529 0.1773
Onchocerca volvulus Putative nachr subunit 0.0626 0.8952 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0626 0.8952 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0377 0.0377
Onchocerca volvulus 0.0626 0.8952 1
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.017 0.0171
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0281 0.0281
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0626 0.8952 0.8952
Echinococcus granulosus intermediate filament protein 0.0027 0.0229 0.0229
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0727 0.3664
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0676 0.3393
Toxoplasma gondii thioredoxin reductase 0.0048 0.0529 0.2607
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0114 0.0091
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0583 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0114 0.0213
Brugia malayi Pre-SET motif family protein 0.0211 0.2908 0.3241
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Echinococcus granulosus expressed protein 0.0378 0.5332 0.5332
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0677 0.0677
Trypanosoma cruzi lanosterol synthase, putative 0.0036 0.0364 0.596
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0626 0.8952 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0626 0.8952 0.8949
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0024 0.0024
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0626 0.8952 0.8952
Schistosoma mansoni microtubule-associated protein tau 0.0698 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0255 0.0267
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0073 0.0049
Schistosoma mansoni cpg binding protein 0.0031 0.0279 0.0256
Onchocerca volvulus 0.0626 0.8952 1
Echinococcus granulosus CREB binding protein 0.0063 0.0753 0.0753
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0479
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.056 0.9588
Echinococcus multilocularis tumor protein p63 0.0342 0.4811 0.4811
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0626 0.8952 0.8949
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.005 0.056 0.0538
Echinococcus multilocularis musashi 0.0027 0.0229 0.0229
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0529 0.0554
Echinococcus multilocularis CREB binding protein 0.0017 0.0077 0.0077
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0091 0.1156 0.1156
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0114 0.0114
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0377 0.6202
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0114 0.0213
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0322 0.0342
Loa Loa (eye worm) hypothetical protein 0.005 0.0561 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0102 0.1324 0.1464
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0626 0.8952 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0626 0.8952 0.8952
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.056 0.9588
Onchocerca volvulus 0.0289 0.4039 0.4367
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0229 0.0246
Loa Loa (eye worm) hypothetical protein 0.0193 0.2642 0.2938
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0114 0.011
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0036 0.0364 0.0396
Toxoplasma gondii hypothetical protein 0.0143 0.1913 1
Echinococcus multilocularis CREB binding protein 0.007 0.0856 0.0856
Giardia lamblia Rab geranylgeranyltransferase 0.005 0.056 0.1896
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0677 0.928
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.011
Echinococcus multilocularis lamin dm0 0.0027 0.0229 0.0229
Onchocerca volvulus 0.0289 0.4039 0.4367
Brugia malayi Cytochrome P450 family protein 0.0023 0.017 0.0179
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0036 0.0364 0.113
Schistosoma mansoni nAChR subunit 0.0289 0.4039 0.4024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0626 0.8952 1
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0091 0.1156 0.1156
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.056 0.9588
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.1057 0.1057
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0583 0.0634
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0529 0.9003
Brugia malayi Cytochrome P450 family protein 0.0034 0.0322 0.0349
Onchocerca volvulus 0.0337 0.4745 0.5177
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0289 0.4039 0.4039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0727 0.0779
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0281 0.0258
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0114 0.0118
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1599 0.1769
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.056 0.9588
Schistosoma mansoni cytochrome P450 0.0014 0.0041 0.0016
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0114 0.0091
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0114 0.0114
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0583 0.0583
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0626 0.8952 1
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0337 0.4745 0.4732
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0626 0.8952 0.8949
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0364 0.596
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0619 0.8846 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0193 0.2642 0.2642
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0073 0.0606
Onchocerca volvulus 0.0626 0.8952 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0626 0.8952 0.8952
Echinococcus multilocularis cpg binding protein 0.0031 0.0279 0.0279
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.3315 0.3691
Brugia malayi Cation transporter family protein 0.0626 0.8952 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1599 0.1769
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0281 0.0281
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0114 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0114 0.0213
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0114 0.0114
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0073 0.0037
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0073 0.0606
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.011
Plasmodium falciparum geranylgeranyltransferase, putative 0.0036 0.0364 0.113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0281 0.0258
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0073 0.0037
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0031 0.0281 0.0296
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0583 0.1637
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0114 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0096 0.0156
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0289 0.4039 0.4506
Schistosoma mansoni lamin 0.0027 0.0229 0.0206
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0677 0.0677
Echinococcus granulosus glycine receptor subunit alpha 1 0.0626 0.8952 0.8952
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.6704 0.6704
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0177 0.0154
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0727 0.0704
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.062 0.0676
Brugia malayi hypothetical protein 0.0289 0.4039 0.4506
Schistosoma mansoni neurotransmitter gated ion channel 0.0337 0.4745 0.4732
Loa Loa (eye worm) hypothetical protein 0.0337 0.4745 0.5292
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0289 0.4039 0.4039
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.024 0.3332 0.3316
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0114 0.011
Giardia lamblia Rab geranylgeranyltransferase 0.0036 0.0364 0.113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0281 0.0258
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.1156 0.1135
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.005 0.056 0.1896
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Echinococcus granulosus thymidine phosphorylase 0.0619 0.8846 0.8846
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0177 0.0726
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0583 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0626 0.8952 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0746 0.0723
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0626 0.8952 1
Toxoplasma gondii hypothetical protein 0.005 0.056 0.2776
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0626 0.8952 1
Leishmania major geranylgeranyltransferase, putative 0.0036 0.0364 0.471
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.005 0.056 0.1569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0096 0.0156
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0177 1
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0036 0.0364 0.0971
Schistosoma mansoni nAChR subunit 0.0626 0.8952 0.8949
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0096 0.0156
Echinococcus multilocularis lamin 0.0027 0.0229 0.0229
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0377 0.0354
Trypanosoma cruzi protein farnesyltransferase, putative 0.0036 0.0364 0.596
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0073 0.0479
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0036 0.0364 0.0396
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0289 0.4039 0.4506
Loa Loa (eye worm) hypothetical protein 0.0626 0.8952 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0073 0.0606
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0114 0.0114
Schistosoma mansoni acetylcholine receptor subunit beta 0.0289 0.4039 0.4024
Onchocerca volvulus 0.0626 0.8952 1
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0073 0.0088
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0364 0.1726
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.5859 0.5859
Mycobacterium tuberculosis Probable reductase 0.0109 0.1421 0.1568
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0626 0.8952 1
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Schistosoma mansoni nAChR subunit 0.0626 0.8952 0.8949
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0626 0.8952 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0036 0.0364 0.0389
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1421 0.1568
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0177 0.2508
Loa Loa (eye worm) hypothetical protein 0.0289 0.4039 0.4502
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0727 0.0704
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.017 0.2381
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0727 0.0779
Mycobacterium ulcerans thymidine phosphorylase 0.0619 0.8846 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0626 0.8952 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0727 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0073 0.0175
Echinococcus granulosus lamin dm0 0.0027 0.0229 0.0229
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0289 0.4039 0.4506
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0114 0.0091
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0193 0.2642 0.2624
Brugia malayi hypothetical protein 0.0289 0.4039 0.4506
Schistosoma mansoni nAChR subunit 0.0289 0.4039 0.4024
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.056 0.9588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0073 0.0606

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.1 nM Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase. ChEMBL. 11392531
IC50 (binding) = 1.1 nM Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase. ChEMBL. 11392531
IC50 (binding) = 520 nM Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-transferase type I. ChEMBL. 11392531
IC50 (binding) = 520 nM Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-transferase type I. ChEMBL. 11392531

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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