Detailed information for compound 282584

Basic information

Technical information
  • TDR Targets ID: 282584
  • Name: 2-[4-[5-(diaminomethylideneamino)-1-benzofura n-2-yl]phenyl]guanidine
  • MW: 308.338 | Formula: C16H16N6O
  • H donors: 4 H acceptors: 0 LogP: 1.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)Nc1ccc(cc1)c1oc2c(c1)cc(cc2)NC(=N)N
  • InChi: 1S/C16H16N6O/c17-15(18)21-11-3-1-9(2-4-11)14-8-10-7-12(22-16(19)20)5-6-13(10)23-14/h1-8H,(H4,17,18,21)(H4,19,20,22)
  • InChiKey: VAYJLYWRLAIDSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(5-guanidinobenzofuran-2-yl)phenyl]guanidine
  • 2-[4-(5-guanidino-2-benzofuranyl)phenyl]guanidine
  • 2-[4-[5-[bis(azanyl)methylideneamino]-1-benzofuran-2-yl]phenyl]guanidine
  • 2-[2-[4-(diaminomethylideneamino)phenyl]-1-benzofuran-5-yl]guanidine
  • 2-[2-(4-guanidinophenyl)benzofuran-5-yl]guanidine
  • 2-[2-(4-guanidinophenyl)-5-benzofuranyl]guanidine
  • AIDS-212607
  • AIDS212607
  • Guanidine, N-[4-[5-[(aminoiminomethyl)amino]-2-benzofuranyl]phenyl]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Protein lozenge 0.0117 0.0366 0.0366
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0064 0.0101
Mycobacterium ulcerans hypothetical protein 0.0038 0.008 0.0249
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0185 0.0308
Brugia malayi hypothetical protein 0.0026 0.0039 0.0113
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0005
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0024 0.0184
Echinococcus granulosus cathepsin l1 0.0018 0.0008 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0917 0.4243
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0039 0.0503
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Schistosoma mansoni coup transcription factor 0.0037 0.0076 0.0142
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.005 0.0126 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0076 0.0224
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0076 0.1082
Onchocerca volvulus Putative organic anion transporter 0.0117 0.0365 0.1085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Echinococcus granulosus transcription factor btf3 0.0037 0.0076 0.0147
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0076 0.0147
Echinococcus multilocularis agrin 0.008 0.0231 0.0231
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0024 0.0258
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0011 0.0056
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.008 0.0231 0.0688
Trichomonas vaginalis glutaminase, putative 0.0286 0.0974 0.4506
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0183 0.0348
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0064 0.0117
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0107 0.0331 0.3631
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0231 0.2511
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Brugia malayi hypothetical protein 0.0019 0.0014 0.0036
Schistosoma mansoni loxhd1 0.0041 0.0093 0.0174
Trypanosoma cruzi NAD+ synthase, putative 0.0086 0.0254 0.0426
Trichomonas vaginalis esterase, putative 0.0038 0.008 0.0371
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0331 0.1532
Echinococcus granulosus RUN 0.0041 0.0093 0.018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0053 0.0102
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0034 0.0097
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0086 0.0254 0.0807
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0007 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0183 0.0348
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0194 0.0642 0.4256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0117 0.0341
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.008 0.0149
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.008 0.0155
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0301 0.1028 0.6815
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.008 0.008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0007 0.0007
Trypanosoma brucei metacaspase MCA2 0.0019 0.0011 0.0012
Schistosoma mansoni multidrug resistance protein 0.0022 0.0024 0.0041
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.009
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0185 0.0308
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0231 0.0694
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Toxoplasma gondii hypothetical protein 0.0265 0.0899 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0194 0.0642 1
Echinococcus granulosus mitogen activated protein kinase 0.0107 0.0331 0.0639
Schistosoma mansoni organic anion transporter 0.0117 0.0365 0.0699
Leishmania major p-glycoprotein 0.0022 0.0024 0.0034
Schistosoma mansoni nuclear receptor 0.0017 0.0007 0.0007
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0076 0.0211
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0024 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0076 0.0142
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0076 0.0211
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Mycobacterium ulcerans beta-lactamase 0.0038 0.008 0.0249
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0222 0.0428
Brugia malayi beta-NAC-like protein 0.0037 0.0076 0.0224
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0076 0.0147
Echinococcus granulosus follistatin 0.008 0.0231 0.0447
Brugia malayi jmjC domain containing protein 0.0127 0.0403 0.1214
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0011 0.0058
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0231 0.0776 0.1319
Brugia malayi hypothetical protein 0.0248 0.0835 0.2522
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0007 0.0013
Brugia malayi nuclear receptor NHR-88 0.0017 0.0007 0.0013
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0064 0.0064
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0024 0.0024
Echinococcus multilocularis pol protein 0.2795 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0024 0.0111
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0052 0.013 0.0246
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Echinococcus multilocularis expressed protein 0.008 0.0231 0.0231
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0076 0.0142
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.033 0.0633
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0008 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0862 0.3048 0.3048
Brugia malayi Inositol-1 0.0039 0.0084 0.0247
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0076 0.0123
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0039 0.006
Entamoeba histolytica hypothetical protein 0.0037 0.0076 0.0319
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.008 0.0149
Echinococcus multilocularis ATP binding cassette sub family B 0.0022 0.0023 0.0023
Leishmania major NAD synthase, putative 0.0086 0.0254 0.0426
Echinococcus granulosus caspase 8 0.0019 0.0011 0.0022
Onchocerca volvulus 0.0117 0.0365 0.1085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Mycobacterium tuberculosis Conserved hypothetical protein 0.0866 0.306 1
Schistosoma mansoni cpg binding protein 0.0064 0.0175 0.0332
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0181 0.0597 0.0597
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0076 0.0224
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0008 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.008 0.0155
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0231 0.0776 0.1319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0076 0.0218
Echinococcus granulosus caspase 2 0.0062 0.0166 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Onchocerca volvulus 0.0018 0.0008 0.0003
Brugia malayi jmjC domain containing protein 0.0033 0.0064 0.0186
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0034 0.0097
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0076 0.0319
Brugia malayi secreted modular calcium-binding protein 1 0.008 0.0231 0.0694
Trypanosoma brucei metacaspase 0.0019 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Brugia malayi Melibiase family protein 0.0072 0.0202 0.0604
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.008 0.0371
Brugia malayi Doublecortin family protein 0.0041 0.0093 0.0275
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0064 0.0117
Brugia malayi SPARC precursor 0.008 0.0231 0.0694
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0183 0.0548
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.033 0.0633
Plasmodium falciparum metacaspase-like protein 0.0019 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0248 0.0835 0.2518
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0076 0.077
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.0202 0.0934
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0617 0.2855
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0024 0.0054
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0616 0.2162 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.0011 0.0016
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0007 0.0007
Brugia malayi Cell death protein 3 precursor 0.0062 0.0166 0.0497
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0194 0.0642 0.4167
Schistosoma mansoni zinc finger protein 0.0017 0.0007 0.0007
Mycobacterium leprae conserved hypothetical protein 0.0038 0.008 0.0318
Brugia malayi beta-lactamase family protein 0.0038 0.008 0.0236
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.0011 0.0016
Brugia malayi Cytochrome P450 family protein 0.0017 0.0004 0.0006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0361 0.3972
Schistosoma mansoni hypothetical protein 0.0177 0.0583 0.112
Mycobacterium ulcerans glutaminase 0.0286 0.0974 0.3174
Schistosoma mansoni transcription factor btf3 0.0037 0.0076 0.0142
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0117 0.0347
Onchocerca volvulus 0.0018 0.0008 0.0003
Brugia malayi conserved hypotetical protein 0.0017 0.0007 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0583 0.2696
Mycobacterium ulcerans hypothetical protein 0.0866 0.306 1
Echinococcus multilocularis muscleblind protein 0.0315 0.1078 0.1078
Schistosoma mansoni follistatin 0.008 0.0231 0.0441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Schistosoma mansoni rab6-interacting 0.0041 0.0093 0.0174
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0778 0.2744 0.4679
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0917 0.4243
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0093 0.0576
Brugia malayi CXXC zinc finger family protein 0.0061 0.0162 0.0485
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0084 0.0136
Brugia malayi steroid hormone receptor 0.0037 0.0076 0.0224
Schistosoma mansoni hypothetical protein 0.0102 0.0312 0.0598
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0034 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0084 0.0136
Onchocerca volvulus 0.0038 0.008 0.0223
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0811 0.2632
Echinococcus granulosus dnaJ subfamily B 0.0862 0.3048 0.5884
Onchocerca volvulus 0.0038 0.008 0.0223
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.018
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0034 0.0068 0.0109
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0008 0.0006
Loa Loa (eye worm) histone methyltransferase 0.002 0.0016 0.0036
Schistosoma mansoni polycystin 1-related 0.0041 0.0093 0.0174
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0076 0.0462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0076 0.0224
Brugia malayi RNA binding protein 0.0066 0.0183 0.0548
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0107 0.0331 0.099
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0269
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0024 0.0076
Echinococcus granulosus lysine specific demethylase 5A 0.0127 0.0403 0.0778
Schistosoma mansoni glutaminase 0.0286 0.0974 0.1876
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0076 0.0218
Plasmodium falciparum enoyl-acyl carrier reductase 0.0194 0.0642 0.427
Brugia malayi hypothetical protein 0.0043 0.01 0.0295
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0064 0.018
Brugia malayi tailless protein 0.0017 0.0007 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.008 0.013
Onchocerca volvulus 0.0117 0.0365 0.1085
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0011 0.0025
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0202 0.0384
Brugia malayi nuclear receptor RXR 0.0017 0.0007 0.0013
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0181 0.0597 0.1152
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0183 0.0542
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0024 0.0046
Brugia malayi sodium-independent organic anion transporter family protein 0.0117 0.0365 0.1097
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0062 0.0062
Brugia malayi ABC transporter family protein 0.0022 0.0024 0.0066
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0084 0.0387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Leishmania major mitochondrial DNA polymerase beta 0.1644 0.586 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.0177 0.0583 0.112
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0039 0.0215
Echinococcus multilocularis pol protein 0.2795 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0401 0.1201
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.043 0.1492 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0062 0.0166 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0076 0.0224
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0011 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0016 0.0031
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.012 0.0378 0.0378
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0003 0.0003
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0024 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0183 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0076 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0107 0.033 0.0638
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0034 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0222 0.0222
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0076 0.0142
Loa Loa (eye worm) hypothetical protein 0.0117 0.0365 0.1092
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0076 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0133 0.0221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0076 0.0076
Plasmodium vivax JmjC domain containing protein 0.0033 0.0064 0.0882
Toxoplasma gondii melibiase subfamily protein 0.0107 0.033 0.3622
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0011 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0057
Onchocerca volvulus 0.008 0.0231 0.0681
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0301 0.1028 0.3342
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0022 0.0024 0.0086
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0008 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0107
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0093 0.018
Entamoeba histolytica hypothetical protein 0.0038 0.008 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Leishmania major cathepsin L-like protease 0.0067 0.0185 0.0308
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0331 0.1532
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0076 0.0353
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.043 0.1492 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0007 0.0013
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0331 0.0634
Onchocerca volvulus 0.0041 0.0093 0.0262
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0617 0.2855
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0194 0.0642 0.2077
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0076 0.0147
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.008 0.0238
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0093 0.0093
Onchocerca volvulus 0.0025 0.0034 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0034 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0084 0.0387
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.0174
Mycobacterium leprae Probable lipase LipE 0.0038 0.008 0.0318
Brugia malayi nuclear receptor NHR-67 0.0017 0.0007 0.0013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0231 0.0776 0.1319
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0007 0.0007
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0064 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0097
Onchocerca volvulus 0.0022 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0034 0.0068 0.0408
Leishmania major hypothetical protein, conserved 0.0038 0.008 0.013
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0011 0.004
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.023
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0117 0.0365 0.1092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Giardia lamblia Fructose-bisphosphate aldolase 0.0616 0.2162 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.009
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0024 0.0076
Brugia malayi Cytochrome P450 family protein 0.0027 0.0043 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0076 0.0224
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0934 0.3305 1
Brugia malayi beta-lactamase 0.0038 0.008 0.0236
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0024 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0039 0.006
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0076 0.0142
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0007 0.0007
Mycobacterium ulcerans lipase LipD 0.0038 0.008 0.0249
Schistosoma mansoni inositol monophosphatase 0.0039 0.0084 0.0156
Onchocerca volvulus 0.0117 0.0365 0.1085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0007 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0126 0.0376
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.008 0.023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0162 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0076 0.0224
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0107 0.0331 0.0558
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0076 0.0147
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.043 0.1492 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0076 0.0123
Schistosoma mansoni hypothetical protein 0.0043 0.01 0.0187
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0011 0.0012
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0064 0.0123
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0008 0.0003
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni cpg binding protein 0.0064 0.0175 0.0332
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0008 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0076 0.0218
Leishmania major hypothetical protein, conserved 0.0026 0.0039 0.006
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0003
Onchocerca volvulus 0.0018 0.0008 0.0003
Brugia malayi ecdysone receptor 0.0017 0.0007 0.0013
Echinococcus granulosus agrin 0.008 0.0231 0.0447
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0011 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0076 0.0142
Plasmodium vivax GMP synthetase, putative 0.0034 0.0068 0.0956
Brugia malayi nuclear receptor RXR 0.0019 0.0014 0.0036
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.008 0.0238
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0008 0.0008
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0039 0.0215
Trypanosoma brucei Metacaspase-4 0.0019 0.0011 0.0012
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0024 0.0076
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis abcb9, putative 0.0022 0.0024 0.0111
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0064 0.0628
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0034 0.0068 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.008 0.0371
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.008 0.0238
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0124 0.0391 0.0391
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0043 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0076 0.0218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0069 0.0201
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0011 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0076 0.0142
Onchocerca volvulus 0.0934 0.3305 1
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0164 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0076 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0038 0.008 0.0238
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.01 0.0193
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0064 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.043 0.1492 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0107 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.008 0.0231 0.0688
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0117 0.0365 0.0365
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.008 0.0238
Brugia malayi hypothetical protein 0.0017 0.0006 0.0011
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0231 0.2511
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0064 0.0123
Onchocerca volvulus 0.0018 0.0008 0.0003
Echinococcus multilocularis cysteine protease 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0117 0.0365 0.1092
Schistosoma mansoni GMP synthetase 0.0034 0.0068 0.0126
Echinococcus granulosus mitogen activated protein kinase 3 0.0107 0.0331 0.0639
Echinococcus multilocularis transcription factor btf3 0.0037 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.0166 0.0316
Onchocerca volvulus 0.005 0.0126 0.0363
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0008 0.0016
Echinococcus multilocularis pol protein 0.2795 1 1
Echinococcus granulosus cpg binding protein 0.0064 0.0175 0.0338
Loa Loa (eye worm) hypothetical protein 0.0315 0.1078 0.3253
Schistosoma mansoni hypothetical protein 0.0862 0.3048 0.5881
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0007 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.014 0.0447 0.0864
Leishmania major basic transcription factor 3a, putative 0.0037 0.0076 0.0123
Schistosoma mansoni microtubule-associated protein tau 0.1455 0.518 1
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0117 0.0365 0.1092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0076 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0076 0.0353
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0022 0.0023 0.0045
Onchocerca volvulus 0.0033 0.0062 0.0167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0034 0.0122
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0086 0.0254 0.3885
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.023
Loa Loa (eye worm) glutaminase 0.0286 0.0974 0.2939
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0064 0.018
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0076 0.0218
Schistosoma mansoni jumonji domain containing protein 0.0124 0.0391 0.0749
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0086 0.0254 0.1174
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0331 0.0558
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0331 0.1532
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0076 0.0224
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0093 0.0269
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0064 0.0101
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0183 0.0183
Plasmodium falciparum multidrug resistance protein 1 0.0022 0.0024 0.011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.009
Loa Loa (eye worm) inositol-1 0.0039 0.0084 0.0241
Brugia malayi hypothetical protein 0.0934 0.3305 1
Schistosoma mansoni lipoxygenase 0.0107 0.0329 0.0631
Loa Loa (eye worm) RNA binding protein 0.0066 0.0183 0.0542
Brugia malayi MAP kinase sur-1 0.0107 0.0331 0.0996
Onchocerca volvulus 0.0041 0.0093 0.0262
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0231 0.2511
Loa Loa (eye worm) beta-lactamase 0.0038 0.008 0.023
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Onchocerca volvulus 0.0249 0.0842 0.2533
Toxoplasma gondii transporter, major facilitator family protein 0.0117 0.0365 0.4007
Brugia malayi jmjC domain containing protein 0.0033 0.0064 0.0186
Schistosoma mansoni nuclear receptor 0.0017 0.0007 0.0007
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0194 0.0642 0.2086
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0194 0.0642 0.7116
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0076 0.0224
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0024 0.0076
Onchocerca volvulus 0.0037 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Echinococcus granulosus geminin 0.0177 0.0583 0.1125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0076 0.0076
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.043 0.1492 0.4863
Brugia malayi sodium-independent organic anion transporter family protein 0.0117 0.0365 0.1097
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0331 0.1532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0076 0.0218
Trypanosoma cruzi MFS transporter, putative 0.0117 0.0365 0.0616
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0024 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0076 0.0224
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0016 0.0016
Schistosoma mansoni lozenge 0.0117 0.0366 0.0702
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0011 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0076 0.0076
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni cpg binding protein 0.0061 0.0162 0.0308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0034 0.0097
Echinococcus granulosus Solute carrier organic anion transporter family 0.0117 0.0365 0.0704
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0076 0.0147
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.01 0.01
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis RUN 0.0041 0.0093 0.0093
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0015 0.0039
Echinococcus granulosus caspase 0.0019 0.0011 0.0022
Brugia malayi hypothetical protein 0.0117 0.0365 0.1097
Plasmodium vivax metacaspase 1, putative 0.0019 0.0011 0.0056
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0024 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0202 0.0384
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0039 0.006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0007 0.0013
Brugia malayi glutaminase DH11.1 0.0286 0.0974 0.2943
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0062 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0062 0.0114
Brugia malayi MH2 domain containing protein 0.0127 0.0401 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Onchocerca volvulus 0.0061 0.0162 0.0472
Onchocerca volvulus 0.0018 0.0008 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0039 0.0358
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0008 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.008 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Mycobacterium ulcerans GMP synthase 0.0034 0.0068 0.021
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.008 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Schistosoma mansoni hypothetical protein 0.0038 0.008 0.0149
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0034 0.0068 0.068
Trichomonas vaginalis abcb9, putative 0.0022 0.0024 0.0111
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0011 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0076 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0076 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0007 0.0013
Brugia malayi hypothetical protein 0.0019 0.0014 0.0036
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0086 0.0254 0.0485
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0014 0.0027
Echinococcus multilocularis cpg binding protein 0.0064 0.0175 0.0175
Echinococcus multilocularis caspase 2 0.0062 0.0166 0.0166
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0117 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0231 0.2511
Loa Loa (eye worm) hypothetical protein 0.008 0.0231 0.0688
Brugia malayi hypothetical protein 0.0041 0.0093 0.0275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0076 0.0224
Brugia malayi Muscleblind-like protein 0.0315 0.1078 0.3257
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0084 0.026
Brugia malayi nuclear hormone receptor 0.0037 0.0076 0.0224
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.0166 0.0484
Schistosoma mansoni agrin 0.008 0.0231 0.0441
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0064 0.0628
Echinococcus multilocularis mitogen activated protein kinase 0.0107 0.0331 0.0331
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0034 0.0086
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0076 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.008 0.013
Onchocerca volvulus 0.0018 0.0008 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1644 0.586 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0007 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.008 0.0236
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0008 0.0009
Giardia lamblia Kinase, CMGC MAPK 0.0107 0.0331 0.0405
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0076 0.0142
Entamoeba histolytica NAD synthetase, putative 0.0086 0.0254 0.1143
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Plasmodium falciparum metacaspase 1 0.0019 0.0011 0.0024
Schistosoma mansoni lipoxygenase 0.0181 0.0597 0.1147
Entamoeba histolytica hypothetical protein 0.0038 0.008 0.0336
Loa Loa (eye worm) DR-78 0.0017 0.0007 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0331 0.0558
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0583 0.2696
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Echinococcus granulosus muscleblind protein 0.0315 0.1078 0.2081
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0086 0.0254 0.2764
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.023
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0014 0.0022
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0093 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0917 0.4243
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.043 0.1492 0.4869
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0185 0.0308
Brugia malayi jmjC domain containing protein 0.0033 0.0064 0.0186
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.033 0.0633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0117 0.0226
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.008 0.0149
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.01 0.0289
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Loa Loa (eye worm) runx1 0.0117 0.0366 0.1096
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0084 0.0162
Schistosoma mansoni retinoic acid receptor RXR 0.014 0.0447 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0062 0.0114
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0064 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.0011 0.0016
Toxoplasma gondii protease inhibitor PI2 0.008 0.0231 0.2511
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0107 0.0331 0.0558
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0025 0.0034 0.0097
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0024 0.0034
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0778 0.2744 0.4679
Mycobacterium tuberculosis Conserved protein 0.0038 0.008 0.0238
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1644 0.586 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0218
Loa Loa (eye worm) hypothetical protein 0.008 0.0231 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1644 0.586 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0008 0.0009
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0064 0.0377
Loa Loa (eye worm) agrin synaptic family protein 0.008 0.0231 0.0688
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0583 0.2696
Loa Loa (eye worm) hypothetical protein 0.0117 0.0365 0.1092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0076 0.0218
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0007 0.0007
Brugia malayi jmjC domain containing protein 0.0124 0.0391 0.1176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0117 0.0365 0.0704
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0064 0.0064
Leishmania major cathepsin L-like protease 0.0067 0.0185 0.0308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi multidrug resistance protein 3 0.0022 0.0024 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0733 0.2209
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.008 0.013
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.023
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0084 0.0353
Toxoplasma gondii ABC1 family protein 0.0038 0.008 0.0814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0007 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.008 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0076 0.0218
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0084 0.0854
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0011 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.008 0.0371
Leishmania major metacaspase, putative 0.0019 0.0011 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0835 0.1612
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0583 0.2696
Schistosoma mansoni jumonji/arid domain-containing protein 0.0127 0.0403 0.0773
Schistosoma mansoni survival motor neuron protein 0.005 0.0126 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0583 0.2696
Trichomonas vaginalis hypothetical protein 0.0194 0.0642 0.2968
Schistosoma mansoni hypothetical protein 0.0041 0.0093 0.0174
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0076 0.0224
Echinococcus granulosus microtubule associated protein 2 0.1455 0.518 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0076 0.0147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0062 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0185 0.0308
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0093 0.0093
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.0917 0.2766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0062 0.0114
Echinococcus multilocularis geminin 0.0177 0.0583 0.0583
Plasmodium vivax SET domain protein, putative 0.0033 0.0062 0.0854
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0194 0.0642 0.3961
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0583 0.2696
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0842 0.3892
Entamoeba histolytica hypothetical protein 0.0038 0.008 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi hypothetical protein 0.0041 0.0093 0.0275
Trypanosoma cruzi NAD+ synthase, putative 0.0086 0.0254 0.0426
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0231 0.0694
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0076 0.0076
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0301 0.1028 0.3349
Echinococcus granulosus tar DNA binding protein 0.0066 0.0183 0.0354
Brugia malayi Pre-SET motif family protein 0.0219 0.0733 0.2213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.001
Schistosoma mansoni organic anion transporter 0.0117 0.0365 0.0699
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0036
Schistosoma mansoni multidrug resistance protein 0.0022 0.0024 0.0041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Trichomonas vaginalis abcb9, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Loa Loa (eye worm) hypothetical protein 0.0117 0.0365 0.1092
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0007 0.0007
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.0917 0.2771
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.043 0.1492 0.649
Onchocerca volvulus Putative organic anion transporter 0.0117 0.0365 0.1085
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0076 0.0076
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0084 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0064 0.0117
Leishmania major hypothetical protein, conserved 0.0033 0.0064 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0038 0.008 0.1144
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0064 0.018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0076 0.0224
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0411 0.0788
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0093 0.1348
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0076 0.0211
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.0403 0.1209
Trichomonas vaginalis taga, putative 0.0022 0.0024 0.0111
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0124 0.0391 0.0754
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0034 0.0068 0.0109
Loa Loa (eye worm) hypothetical protein 0.0315 0.1078 0.3253
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0034 0.0122
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.008 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0183 0.0348
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.023
Echinococcus multilocularis lysine specific demethylase 5A 0.0124 0.0391 0.0391
Brugia malayi sodium-independent organic anion transporter family protein 0.0117 0.0365 0.1097
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0583 0.2696
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0076 0.0147
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0778 0.2744 0.4679
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0093 0.018
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0231 0.0694
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0024 0.0111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0084 0.0136
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0011 0.004
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0231 0.0694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0076 0.0076
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0008 0.0015
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0835 0.0835
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0616 0.2162 1
Loa Loa (eye worm) ctsf protein 0.0018 0.0008 0.001
Trypanosoma brucei RNA helicase, putative 0.0102 0.0312 0.0526
Onchocerca volvulus Putative organic anion transporter 0.0117 0.0365 0.1085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0127 0.0403 0.0773
Loa Loa (eye worm) hypothetical protein 0.0934 0.3305 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0096
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0185 0.0308
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.008 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0096
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0076 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0062 0.0114
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.008 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0183 0.0348
Schistosoma mansoni rab6-interacting 0.0041 0.0093 0.0174
Entamoeba histolytica hypothetical protein 0.0038 0.008 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.0583 0.1747
Loa Loa (eye worm) hypothetical protein 0.008 0.0231 0.0688
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0117 0.0226
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0231 0.0776 0.1319
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0282 0.0958 0.1629
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0064 0.0064
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0024 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Echinococcus multilocularis follistatin 0.008 0.0231 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0917 0.4243
Schistosoma mansoni inositol monophosphatase 0.0039 0.0084 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0917 0.4243
Brugia malayi prostaglandin transporter 0.0117 0.0365 0.1097
Onchocerca volvulus 0.0038 0.008 0.0223
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0117 0.0365 0.1092
Onchocerca volvulus 0.0018 0.0008 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0014 0.0022
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0007 0.0013
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0086 0.0254 0.1659
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0069 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0076 0.0076
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0024 0.0024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0183 0.0542
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0014 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0036
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0086 0.0254 0.1509
Trypanosoma brucei NAD+ synthase, putative 0.0086 0.0254 0.0426
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0007 0.0013
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0076 0.0142
Mycobacterium tuberculosis Conserved protein 0.0038 0.008 0.0238
Trypanosoma brucei protein kinase, putative 0.0107 0.0331 0.0558
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0107 0.0331 0.0558
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0076 0.0076
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0024 0.0184
Echinococcus multilocularis cysteine protease 0.0018 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0076 0.0218
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0024 0.0076
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0008 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.008 0.0249
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Brugia malayi jmjC domain containing protein 0.0033 0.0064 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi GMP synthase 0.0034 0.0068 0.02
Loa Loa (eye worm) fibroinase 0.0018 0.0008 0.001
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0093 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.2162 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0117 0.0117
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0072 0.0202 0.0599
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0076 0.0224
Brugia malayi hypothetical protein 0.0117 0.0365 0.1097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0117 0.022
Brugia malayi Cytochrome P450 family protein 0.0017 0.0004 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0076 0.0224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0117 0.022
Leishmania major cathepsin L-like protease 0.0067 0.0185 0.0308
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0107 0.0331 0.0558
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0084 0.0136
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0064 0.0117
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis caspase 8 0.0019 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0096
Loa Loa (eye worm) cysteine protease 0.0018 0.0008 0.001
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis caspase 0.0019 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0007 0.0007
Brugia malayi nuclear receptor NHR-88 0.0037 0.0076 0.0224
Schistosoma mansoni smdr2 0.0022 0.0024 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0917 0.4243
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0062 0.0119
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0107 0.033 0.033
Echinococcus multilocularis mitogen activated protein kinase 3 0.0107 0.0331 0.0331
Onchocerca volvulus 0.0117 0.0365 0.1085
Loa Loa (eye worm) hypothetical protein 0.0117 0.0365 0.1092
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0034 0.0097
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0076 0.0142
Brugia malayi nuclear hormone receptor 0.0017 0.0007 0.0013
Brugia malayi TAR-binding protein 0.0066 0.0183 0.0548
Echinococcus multilocularis microtubule associated protein 2 0.1455 0.518 0.518
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0107 0.0331 0.0558
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0097
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.033 0.0633
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0014 0.0014
Treponema pallidum fructose-bisphosphate aldolase 0.0616 0.2162 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0401 0.1201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0007 0.0013
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.018
Echinococcus multilocularis muscleblind protein 1 0.0315 0.1078 0.1078
Onchocerca volvulus 0.0043 0.01 0.0282
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0008 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0117 0.0117
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.0038 0.008 0.0236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Mycobacterium ulcerans NAD synthetase 0.0086 0.0254 0.0817
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0011 0.0023
Schistosoma mansoni multidrug resistance protein 0.0022 0.0024 0.0041
Echinococcus granulosus phd:f box containing protein 0.0033 0.0064 0.0123
Loa Loa (eye worm) glutaminase 2 0.0286 0.0974 0.2939
Brugia malayi Pre-SET motif family protein 0.0033 0.0062 0.018
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Trypanosoma brucei metacaspase MCA3 0.0019 0.0011 0.0012
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0117 0.0365 0.0365
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0076 0.0142
Brugia malayi beta-lactamase family protein 0.0038 0.008 0.0236
Brugia malayi ecdysteroid receptor 0.0037 0.0076 0.0224
Onchocerca volvulus 0.0117 0.0365 0.1085

Activities

Activity type Activity value Assay description Source Reference
ID50 (binding) = 8 ug ml-1 Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus ChEMBL. 6157024
ID50 (binding) = 8 ug ml-1 Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus ChEMBL. 6157024

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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