Detailed information for compound 282585

Basic information

Technical information
  • TDR Targets ID: 282585
  • Name: 3-amino-2-(4-carbamimidoylphenyl)-1-benzothio phene-5-carboximidamide
  • MW: 309.389 | Formula: C16H15N5S
  • H donors: 3 H acceptors: 0 LogP: 1.85 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)c1ccc(cc1)c1sc2c(c1N)cc(cc2)C(=N)N
  • InChi: 1S/C16H15N5S/c17-13-11-7-10(16(20)21)5-6-12(11)22-14(13)8-1-3-9(4-2-8)15(18)19/h1-7H,17H2,(H3,18,19)(H3,20,21)
  • InChiKey: PRJODRDINXZSJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-amino-2-(4-carbamimidoylphenyl)benzothiophene-5-carboxamidine
  • 3-amino-2-(4-carbamimidoylphenyl)-5-benzothiophenecarboxamidine
  • 3-azanyl-2-(4-carbamimidoylphenyl)-1-benzothiophene-5-carboximidamide
  • 2-(4-amidinophenyl)-3-amino-benzothiophene-5-carboxamidine
  • AIDS-212613
  • AIDS212613
  • Benzo[b]thiophene-5-carboximidamide, 3-amino-2-[4-(aminoiminomethyl)phenyl]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0054 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Schistosoma mansoni hypothetical protein 0.0044 0.0087 0.019
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0067 0.0105
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0021 0.0029
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0437 0.1308 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0067 0.022
Trypanosoma brucei protein kinase, putative 0.0108 0.0287 0.0472
Brugia malayi CXXC zinc finger family protein 0.0061 0.0141 0.0484
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.007 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0067 0.0226
Schistosoma mansoni survival motor neuron protein 0.0051 0.0111 0.0241
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0013 0.0038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0067 0.0144
Echinococcus multilocularis cysteine protease 0.0018 0.0007 0.0007
Echinococcus granulosus agrin 0.0081 0.0203 0.045
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0002 0.0005
Onchocerca volvulus 0.0018 0.0007 0.0003
Leishmania major cathepsin L-like protease 0.0068 0.0162 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0067 0.0226
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.0215
Schistosoma mansoni cpg binding protein 0.0064 0.0152 0.0332
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Onchocerca volvulus 0.0018 0.0007 0.0003
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0022 0.002 0.0045
Onchocerca volvulus 0.0018 0.0007 0.0003
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0021 0.006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Trypanosoma cruzi metacaspase, putative 0.0019 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Mycobacterium ulcerans GMP synthase 0.0035 0.006 0.0179
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.007 0.0203
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0006 0.0013
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0035 0.006 0.0133
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0012 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0038 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0067 0.022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0006 0.0006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0125 0.0339 0.0754
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.007 0.0374
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.007 0.0203
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0061 0.0242
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0055 0.0117
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0021 0.0112
Loa Loa (eye worm) hypothetical protein 0.0081 0.0203 0.0694
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0021 0.0021
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0437 0.1308 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0108 0.0287 0.0989
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0087 0.0194
Mycobacterium tuberculosis Conserved protein 0.0038 0.007 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0054 0.0116
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0067 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0141 0.0478
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0162 0.0264
Mycobacterium tuberculosis Conserved hypothetical protein 0.1028 0.3142 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0067 0.0144
Echinococcus multilocularis pol protein 0.3236 1 1
Onchocerca volvulus 0.0051 0.0111 0.0366
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Schistosoma mansoni cpg binding protein 0.0064 0.0152 0.0332
Schistosoma mansoni caspase-7 (C14 family) 0.0063 0.0146 0.0319
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Echinococcus multilocularis transcription factor btf3 0.0037 0.0067 0.0067
Trypanosoma cruzi metacaspase, putative 0.0019 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0119 0.032 0.1101
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0035 0.006 0.0576
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0287 0.0634
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0081 0.0203 0.2127
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0055 0.0122
Trypanosoma brucei metacaspase 0.0019 0.001 0.001
Brugia malayi prostaglandin transporter 0.0119 0.032 0.1107
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0055 0.0055
Schistosoma mansoni nuclear receptor 0.0018 0.0006 0.0008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.007 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0067 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0067 0.0356
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.001 0.001
Echinococcus multilocularis microtubule associated protein 2 0.1466 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0119 0.032 0.1101
Leishmania major basic transcription factor 3a, putative 0.0037 0.0067 0.0105
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0923 0.2819 0.4687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Schistosoma mansoni retinoic acid receptor RXR 0.0142 0.0392 0.0867
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0334 0.099 0.1642
Mycobacterium ulcerans NAD synthetase 0.0087 0.0223 0.0697
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0108 0.0287 0.0472
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0109 0.029 0.0639
Schistosoma mansoni jumonji domain containing protein 0.0125 0.0339 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0067 0.022
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.003 0.0073
Schistosoma mansoni glutaminase 0.0291 0.0854 0.1893
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0087 0.0223 0.049
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0055 0.0178
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0021 0.0021
Onchocerca volvulus 0.0033 0.0054 0.0168
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0021 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1951 0.601 1
Echinococcus granulosus geminin 0.018 0.0511 0.1134
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0073 0.039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0021 0.0112
Onchocerca volvulus Putative organic anion transporter 0.0119 0.032 0.1095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0054 0.0054
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0161 0.0161
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0021 0.0021
Schistosoma mansoni lipoxygenase 0.0184 0.0523 0.1157
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0006 0.0014
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0161 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0067 0.0226
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0021 0.0112
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0021 0.0112
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0012 0.0023
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0122 0.0331 0.0331
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0052
Onchocerca volvulus Cell death protein 3 homolog 0.0063 0.0146 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0067 0.0226
Echinococcus granulosus caspase 0.0019 0.001 0.0022
Echinococcus multilocularis pol protein 0.3236 1 1
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0437 0.1308 1
Leishmania major hypothetical protein, conserved 0.0027 0.0035 0.0051
Brugia malayi jmjC domain containing protein 0.0128 0.035 0.1213
Trypanosoma cruzi MFS transporter, putative 0.0119 0.032 0.0526
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0005
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0067 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0194 0.0432
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0035 0.006 0.006
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0021 0.0021
Echinococcus granulosus mitogen activated protein kinase 3 0.0108 0.0287 0.0638
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0006 0.0014
Plasmodium falciparum multidrug resistance protein 1 0.0022 0.0021 0.011
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0021 0.0258
Echinococcus multilocularis agrin 0.0081 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0317 0.0936 0.3252
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0055 0.0522
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Echinococcus multilocularis mitogen activated protein kinase 3 0.0108 0.0287 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0067 0.0144
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0117 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0067 0.0067
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0006 0.0014
Onchocerca volvulus 0.0042 0.0082 0.0264
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0108 0.0287 0.3045
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0541 0.2879
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0197 0.0562 0.3961
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0021
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0067 0.0356
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0437 0.1308 0.4154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0109 0.029 0.0639
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0082 0.0181
Plasmodium vivax hypothetical protein, conserved 0.0019 0.001 0.0056
Entamoeba histolytica hypothetical protein 0.0038 0.007 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0035 0.0503
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.003 0.0083
Leishmania major hypothetical protein, conserved 0.0038 0.007 0.0111
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0021 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.003 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0052
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0061 0.0172
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0054 0.0514
Mycobacterium leprae Probable lipase LipE 0.0038 0.007 0.0318
Schistosoma mansoni zinc finger protein 0.0018 0.0006 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.0711 0.2245
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0176
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.003 0.0083
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0073 0.039
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.003 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.007 0.0203
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0082 0.0082
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0021 0.0112
Onchocerca volvulus 0.0018 0.0007 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0067 0.0148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Brugia malayi Cytochrome P450 family protein 0.0028 0.0038 0.0125
Echinococcus granulosus cathepsin l1 0.0018 0.0007 0.0015
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.1879 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.003 0.0083
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Onchocerca volvulus 0.0119 0.032 0.1095
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0066 0.0146
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0232
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0014 0.0014
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0002 0.0002
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0119 0.032 0.071
Schistosoma mansoni inositol monophosphatase 0.0039 0.0073 0.0158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0006 0.0008
Mycobacterium ulcerans lipase LipD 0.0038 0.007 0.0212
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0035 0.0215
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0067 0.0144
Brugia malayi AMP-binding enzyme family protein 0.0025 0.003 0.0097
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0021 0.0112
Onchocerca volvulus 0.0941 0.2872 1
Brugia malayi beta-lactamase 0.0038 0.007 0.0238
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0067 0.0226
Onchocerca volvulus 0.0018 0.0007 0.0003
Brugia malayi Pre-SET motif family protein 0.0033 0.0054 0.0182
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0063 0.0146 0.0495
Loa Loa (eye worm) hypothetical protein 0.0251 0.0732 0.2539
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0007 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.007 0.0156
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0067 0.0226
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0184 0.0523 0.0523
Echinococcus multilocularis cpg binding protein 0.0064 0.0152 0.0152
Brugia malayi Doublecortin family protein 0.0042 0.0082 0.0278
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0055 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.007 0.0374
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0177 0.0388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Brugia malayi secreted modular calcium-binding protein 1 0.0081 0.0203 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.003 0.0043
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0067 0.0321
Onchocerca volvulus 0.0253 0.0738 0.2554
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.001 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0161 0.0547
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0287 0.153
Brugia malayi SPARC precursor 0.0081 0.0203 0.07
Mycobacterium leprae conserved hypothetical protein 0.0038 0.007 0.0318
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0007 0.001
Trichomonas vaginalis hypothetical protein 0.0197 0.0562 0.2993
Echinococcus granulosus caspase 2 0.0063 0.0146 0.0324
Leishmania major cathepsin L-like protease 0.0068 0.0162 0.0264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.001
Brugia malayi hypothetical protein 0.002 0.0012 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0541 0.2879
Plasmodium falciparum metacaspase-like protein 0.0019 0.001 0.0024
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0021 0.0021
Treponema pallidum fructose-bisphosphate aldolase 0.0621 0.1879 1
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0067 0.0652
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0073 0.0177 0.0604
Schistosoma mansoni follistatin 0.0081 0.0203 0.0446
Loa Loa (eye worm) hypothetical protein 0.0941 0.2872 1
Echinococcus multilocularis muscleblind protein 0.0317 0.0936 0.0936
Schistosoma mansoni transcription factor btf3 0.0037 0.0067 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0102 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0511 0.2719
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0005
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.0511 0.1762
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0303 0.0893 0.2826
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0314 0.3332
Loa Loa (eye worm) fibroinase 0.0018 0.0007 0.001
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0012 0.003
Brugia malayi beta-lactamase family protein 0.0038 0.007 0.0238
Plasmodium vivax metacaspase 1, putative 0.0019 0.001 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0025 0.003 0.0097
Schistosoma mansoni hypothetical protein 0.0103 0.0271 0.0597
Brugia malayi steroid hormone receptor 0.0037 0.0067 0.0226
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0804 0.4279
Schistosoma mansoni cpg binding protein 0.0061 0.0141 0.0308
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0082 0.0576
Echinococcus multilocularis dnaJ subfamily B 0.0869 0.2649 0.2649
Echinococcus granulosus RUN 0.0042 0.0082 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0067 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0067 0.0462
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0161 0.0352
Schistosoma mansoni polycystin 1-related 0.0042 0.0082 0.0177
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.003
Plasmodium vivax GMP synthetase, putative 0.0035 0.006 0.0956
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0038 0.007 0.0225
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0923 0.2819 0.4687
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.0116
Onchocerca volvulus 0.0038 0.007 0.0225
Brugia malayi hypothetical protein 0.0251 0.0732 0.2543
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.001 0.0025
Brugia malayi Melibiase family protein 0.0073 0.0177 0.061
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.007 0.0111
Schistosoma mansoni lozenge 0.0118 0.0318 0.0702
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0055 0.0178
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0021 0.0077
Loa Loa (eye worm) glutaminase 0.0291 0.0854 0.2963
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.035 0.1207
Loa Loa (eye worm) hypothetical protein 0.0042 0.0082 0.0271
Brugia malayi hypothetical protein 0.0044 0.0087 0.0298
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0197 0.0562 0.4256
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0067 0.022
Brugia malayi MAP kinase sur-1 0.0108 0.0287 0.0995
Schistosoma mansoni smdr2 0.0022 0.0021 0.0042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Schistosoma mansoni hypothetical protein 0.0051 0.0111 0.0241
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Brugia malayi hypothetical protein 0.0018 0.0006 0.0014
Schistosoma mansoni coup transcription factor 0.0037 0.0067 0.0144
Trypanosoma cruzi metacaspase, putative 0.0019 0.001 0.001
Brugia malayi hypothetical protein 0.0027 0.0035 0.0114
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0006 0.0007
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0275 0.0804 0.279
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0035 0.0051
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0021 0.0112
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0119 0.032 0.032
Mycobacterium ulcerans hypothetical protein 0.0038 0.007 0.0212
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0055 0.0522
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.001 0.0058
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0081 0.0203 0.0694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0067 0.0148
Echinococcus multilocularis expressed protein 0.0081 0.0203 0.0203
Schistosoma mansoni multidrug resistance protein 0.0022 0.0021 0.0042
Echinococcus granulosus transcription factor btf3 0.0037 0.0067 0.0148
Brugia malayi nuclear receptor NHR-88 0.0018 0.0006 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Brugia malayi beta-NAC-like protein 0.0037 0.0067 0.0226
Loa Loa (eye worm) hypothetical protein 0.0119 0.032 0.1101
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0067 0.0226
Schistosoma mansoni loxhd1 0.0042 0.0082 0.0177
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0021 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.003
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0081 0.0203 0.2127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0054 0.0116
Schistosoma mansoni lipoxygenase 0.0109 0.0289 0.0637
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0161 0.0352
Mycobacterium ulcerans glutaminase 0.0291 0.0854 0.2708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0102 0.0344
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0621 0.1879 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0197 0.0562 0.1779
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0161 0.0352
Brugia malayi Cytochrome P450 family protein 0.0017 0.0004 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0162 0.0264
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.001 0.0034
Mycobacterium ulcerans hypothetical protein 0.0025 0.003 0.0083
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0046 0.0103
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0087 0.0223 0.0688
Trypanosoma cruzi NAD+ synthase, putative 0.0087 0.0223 0.0364
Trichomonas vaginalis esterase, putative 0.0038 0.007 0.0374
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0109 0.029 0.029
Schistosoma mansoni rab6-interacting 0.0042 0.0082 0.0177
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0197 0.0562 0.1772
Brugia malayi hypothetical protein 0.0017 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.003
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0081 0.0203 0.07
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0804 0.4279
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0073 0.0073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.003 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Echinococcus multilocularis caspase 8 0.0019 0.001 0.001
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0021 0.0047
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0303 0.0893 0.2833
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.007 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.007 0.0156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.007 0.0151
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0067 0.0213
Onchocerca volvulus 0.0018 0.0007 0.0003
Schistosoma mansoni multidrug resistance protein 0.0022 0.0021 0.0042
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0067 0.0144
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0067 0.0213
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0021 0.0047
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0006 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0108 0.0287 0.0472
Echinococcus granulosus Solute carrier organic anion transporter family 0.0119 0.032 0.071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Onchocerca volvulus 0.0081 0.0203 0.0687
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0052 0.0114 0.0249
Trichomonas vaginalis taga, putative 0.0022 0.0021 0.0112
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0022 0.0021 0.0086
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0021 0.0047
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Echinococcus multilocularis pol protein 0.3236 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0055 0.0055
Brugia malayi MH2 domain containing protein 0.0127 0.0345 0.1194
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.0732 0.1626
Trypanosoma brucei metacaspase 5, putative 0.0019 0.001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0274 0.0803 0.1331
Echinococcus granulosus follistatin 0.0081 0.0203 0.045
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0194 0.0194
Mycobacterium ulcerans beta-lactamase 0.0038 0.007 0.0212
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0067 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0067 0.0226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0119 0.032 0.1101
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.001 0.0017
Brugia malayi hypothetical protein 0.0941 0.2872 1
Leishmania major NAD synthase, putative 0.0087 0.0223 0.0364
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0021 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.007 0.0151
Entamoeba histolytica hypothetical protein 0.0037 0.0067 0.0321
Brugia malayi Inositol-1 0.0039 0.0073 0.0249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0108
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0067 0.0105
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0923 0.2819 0.4687
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0007 0.0003
Echinococcus multilocularis mitogen activated protein kinase 0.0108 0.0287 0.0287
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0067 0.0144
Brugia malayi nuclear hormone receptor 0.0018 0.0006 0.0014
Onchocerca volvulus 0.0119 0.032 0.1095
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0007 0.0007
Loa Loa (eye worm) histone methyltransferase 0.002 0.0014 0.0035
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0804 0.4279
Onchocerca volvulus 0.0119 0.032 0.1095
Onchocerca volvulus 0.0038 0.007 0.0225
Trichomonas vaginalis glutaminase, putative 0.0291 0.0854 0.4544
Schistosoma mansoni inositol monophosphatase 0.0039 0.0073 0.0158
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0021 0.0112
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0081 0.0203 0.07
Brugia malayi ecdysone receptor 0.0018 0.0006 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0287 0.153
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0067 0.0067
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0108 0.0287 0.0472
Mycobacterium tuberculosis Conserved protein 0.0038 0.007 0.0203
Brugia malayi nuclear receptor NHR-88 0.0037 0.0067 0.0226
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0087 0.0223 0.2341
Trypanosoma brucei NAD+ synthase, putative 0.0087 0.0223 0.0364
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.001 0.0017
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0006 0.0008
Trypanosoma brucei Metacaspase-4 0.0019 0.001 0.001
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0021 0.0077
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0067 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0161 0.0352
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0087 0.0223 0.1659
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0035 0.006 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0102 0.0102
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0082 0.0181
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Brugia malayi GMP synthase 0.0035 0.006 0.0202
Brugia malayi conserved hypotetical protein 0.0018 0.0006 0.0014
Trichomonas vaginalis abcb9, putative 0.0022 0.0021 0.0112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0178
Trypanosoma cruzi metacaspase, putative 0.0019 0.001 0.001
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0055 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.007 0.0212
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0067 0.0144
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0021 0.0112
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0007 0.0003
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0102 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0287 0.153
Brugia malayi tailless protein 0.0018 0.0006 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0067 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0102 0.0223
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0177 0.0388
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0067 0.0226
Loa Loa (eye worm) hypothetical protein 0.0119 0.032 0.1101
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0091
Echinococcus multilocularis cysteine protease 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.0058
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0067 0.1082
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0007 0.0036
Echinococcus multilocularis caspase 0.0019 0.001 0.001
Leishmania major p-glycoprotein 0.0022 0.0021 0.0029
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0007 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.003 0.0083
Brugia malayi jmjC domain containing protein 0.0033 0.0055 0.0184
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.003
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0108 0.0287 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0108 0.0287 0.0472
Schistosoma mansoni microtubule-associated protein tau 0.1466 0.4502 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.003 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0161 0.0352
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0119 0.032 0.1101
Onchocerca volvulus 0.0119 0.032 0.1095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0067 0.0226
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.003 0.0123
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0109 0.029 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0804 0.4279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0054 0.0116
Toxoplasma gondii melibiase subfamily protein 0.0109 0.029 0.3068
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0232
Entamoeba histolytica NAD synthetase, putative 0.0087 0.0223 0.1153
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0012 0.0036
Echinococcus multilocularis ATP binding cassette sub family B 0.0022 0.002 0.002
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0055 0.0117
Brugia malayi hypothetical protein 0.0038 0.007 0.0238
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0102 0.0102
Loa Loa (eye worm) cysteine protease 0.0018 0.0007 0.001
Echinococcus granulosus muscleblind protein 0.0317 0.0936 0.208
Loa Loa (eye worm) hypothetical protein 0.0033 0.0055 0.0178
Onchocerca volvulus 0.0044 0.0087 0.0285
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0006 0.0014
Brugia malayi Cytochrome P450 family protein 0.0017 0.0004 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0345 0.1188
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0119 0.032 0.1101
Brugia malayi ecdysteroid receptor 0.0037 0.0067 0.0226
Brugia malayi beta-lactamase family protein 0.0038 0.007 0.0238
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0067 0.0144
Brugia malayi hypothetical protein 0.0119 0.032 0.1107
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0021 0.0112
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.001 0.001
Brugia malayi glutaminase DH11.1 0.0291 0.0854 0.2968
Brugia malayi jmjC domain containing protein 0.0033 0.0055 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0511 0.2719
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0197 0.0562 0.4167
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0055 0.0117
Plasmodium vivax JmjC domain containing protein 0.0033 0.0055 0.0867
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0511 0.2719
Brugia malayi Pre-SET motif family protein 0.0223 0.0643 0.2232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Toxoplasma gondii hypothetical protein 0.0315 0.0929 1
Echinococcus granulosus tar DNA binding protein 0.0067 0.0161 0.0357
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0067 0.0067
Echinococcus multilocularis follistatin 0.0081 0.0203 0.0203
Entamoeba histolytica hypothetical protein 0.0038 0.007 0.0339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Trypanosoma cruzi NAD+ synthase, putative 0.0087 0.0223 0.0364
Brugia malayi hypothetical protein 0.0042 0.0082 0.0278
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0274 0.0803 0.1331
Brugia malayi sodium-independent organic anion transporter family protein 0.0119 0.032 0.1107
Brugia malayi hypothetical protein 0.0018 0.0006 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.006
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.001 0.0022
Brugia malayi multidrug resistance protein 3 0.0022 0.0021 0.0067
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0021 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0021 0.0112
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0012 0.0027
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0007 0.0015
Onchocerca volvulus 0.0119 0.032 0.1095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0357 0.0788
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0055 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0067 0.0067
Brugia malayi jmjC domain containing protein 0.0033 0.0055 0.0184
Plasmodium vivax hypothetical protein, conserved 0.0038 0.007 0.1144
Trypanosoma brucei metacaspase MCA3 0.0019 0.001 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0054 0.012
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0073 0.039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0067 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0804 0.4279
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0006 0.0006
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0437 0.1308 0.4149
Brugia malayi sodium-independent organic anion transporter family protein 0.0119 0.032 0.1107
Loa Loa (eye worm) RNA binding protein 0.0067 0.0161 0.0547
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.007 0.0374
Loa Loa (eye worm) runx1 0.0118 0.0318 0.1095
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0125 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0232
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0035 0.006 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0025 0.003 0.0097
Echinococcus multilocularis muscleblind protein 1 0.0317 0.0936 0.0936
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0021 0.0047
Echinococcus multilocularis lysine specific demethylase 5A 0.0125 0.0339 0.0339
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.035 0.0773
Trichomonas vaginalis abcb9, putative 0.0022 0.0021 0.0112
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0082 0.1348
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0067 0.0213
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0081 0.0203 0.07
Plasmodium falciparum metacaspase 1 0.0019 0.001 0.0024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.0116
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0081 0.0203 0.07
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0021 0.0112
Schistosoma mansoni hypothetical protein 0.0042 0.0082 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0067 0.0148
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0021 0.0077
Echinococcus granulosus dnaJ subfamily B 0.0869 0.2649 0.5883
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0511 0.2719
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.007 0.0212
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0055 0.0085
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0067 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.003 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.007 0.0203
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0091
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0941 0.2872 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0621 0.1879 1
Onchocerca volvulus Putative organic anion transporter 0.0119 0.032 0.1095
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.035 0.0773
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0007 0.0003
Trypanosoma brucei RNA helicase, putative 0.0103 0.0271 0.0445
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0274 0.0803 0.1331
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0066 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0621 0.1879 1
Loa Loa (eye worm) glutaminase 2 0.0291 0.0854 0.2963
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0055 0.0055
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0021 0.0077
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.0732 0.0732
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0102 0.0227
Loa Loa (eye worm) hypothetical protein 0.0081 0.0203 0.0694
Echinococcus multilocularis geminin 0.018 0.0511 0.0511
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0161 0.0553
Schistosoma mansoni rab6-interacting 0.0042 0.0082 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Entamoeba histolytica hypothetical protein 0.0038 0.007 0.0339
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0087 0.0223 0.1509
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0109 0.029 0.0639
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0067 0.0144
Onchocerca volvulus 0.0022 0.0021 0.0053
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.007 0.0238
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Onchocerca volvulus 0.0018 0.0007 0.0003
Schistosoma mansoni nuclear receptor 0.0018 0.0006 0.0008
Leishmania major mitochondrial DNA polymerase beta 0.1951 0.601 1
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0287 0.153
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.007 0.0111
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0091
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0067 0.0067
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0055 0.0122
Brugia malayi Muscleblind-like protein 0.0317 0.0936 0.3256
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0021 0.0077
Schistosoma mansoni hypothetical protein 0.018 0.0511 0.113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Giardia lamblia Kinase, CMGC MAPK 0.0108 0.0287 0.0392
Entamoeba histolytica hypothetical protein 0.0038 0.007 0.0339
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0184 0.0523 0.1162
Leishmania major metacaspase, putative 0.0019 0.001 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0119 0.032 0.1101
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0073 0.0163
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.007 0.0151
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0021 0.0112
Loa Loa (eye worm) hypothetical protein 0.0044 0.0087 0.0292
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0102 0.035
Echinococcus granulosus mitogen activated protein kinase 0.0108 0.0287 0.0638
Leishmania major hypothetical protein, conserved 0.0033 0.0055 0.0085
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0437 0.1308 0.6552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0082 0.0082
Brugia malayi nuclear receptor RXR 0.002 0.0012 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0275 0.0804 0.4279
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0232
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0087 0.0223 0.1184
Schistosoma mansoni hypothetical protein 0.0869 0.2649 0.5881
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0021 0.0047
Onchocerca volvulus 0.0025 0.003 0.0083
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0109 0.029 0.0639
Loa Loa (eye worm) DR-78 0.0018 0.0006 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Toxoplasma gondii protease inhibitor PI2 0.0081 0.0203 0.2127
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0007 0.001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0006 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0142 0.0392 0.0871
Brugia malayi jmjC domain containing protein 0.0033 0.0055 0.0184
Plasmodium vivax SET domain protein, putative 0.0033 0.0054 0.0853
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.022
Brugia malayi ABC transporter family protein 0.0022 0.0021 0.0067
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.003 0.0043
Mycobacterium tuberculosis Conserved protein 0.0038 0.007 0.0203
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1951 0.601 1
Schistosoma mansoni organic anion transporter 0.0119 0.032 0.0705
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0007 0.0015
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0055 0.0055
Leishmania major cathepsin L-like protease 0.0068 0.0162 0.0264
Brugia malayi jmjC domain containing protein 0.0125 0.0339 0.1175
Loa Loa (eye worm) hypothetical protein 0.0042 0.0082 0.0271
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0007 0.0036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0067 0.022
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0006 0.0008
Brugia malayi sodium-independent organic anion transporter family protein 0.0119 0.032 0.1107
Echinococcus granulosus phd:f box containing protein 0.0033 0.0055 0.0122
Schistosoma mansoni hypothetical protein 0.018 0.0511 0.113
Loa Loa (eye worm) agrin synaptic family protein 0.0081 0.0203 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.001 0.0052
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1951 0.601 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0081 0.0203 0.0694
Trichomonas vaginalis set domain proteins, putative 0.0253 0.0737 0.3925
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.007 0.0374
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0067 0.022
Trypanosoma brucei metacaspase MCA2 0.0019 0.001 0.001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0073 0.0723
Loa Loa (eye worm) ctsf protein 0.0018 0.0007 0.001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.007 0.0203
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0162 0.0264
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0073 0.0356
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0232
Toxoplasma gondii ABC1 family protein 0.0038 0.007 0.069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.0643 0.2227
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.007 0.0111
Trichomonas vaginalis abcb9, putative 0.0022 0.0021 0.0112
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0275 0.0804 0.2794
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0082 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0162 0.0264
Echinococcus granulosus microtubule associated protein 2 0.1466 0.4502 1
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0067 0.0148
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0055 0.0085
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0082 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0067 0.0226
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0021 0.0047
Plasmodium falciparum enoyl-acyl carrier reductase 0.0197 0.0562 0.427
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0511 0.2719
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0111 0.0379
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0511 0.2719
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.035 0.0778
Loa Loa (eye worm) inositol-1 0.0039 0.0073 0.0243
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.003 0.0123
Brugia malayi RNA binding protein 0.0067 0.0161 0.0553
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0021 0.0112
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0055 0.0117
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0082 0.0271
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0021 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0067 0.0226
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0197 0.0562 0.6027
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0055 0.0117
Toxoplasma gondii transporter, major facilitator family protein 0.0119 0.032 0.3394
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0006 0.0007
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.001 0.0034
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0274 0.0803 0.1331
Loa Loa (eye worm) beta-lactamase 0.0038 0.007 0.0232
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0081 0.0203 0.2127
Onchocerca volvulus 0.0042 0.0082 0.0264
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0108 0.0287 0.0472
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0108 0.0287 0.0472
Brugia malayi TAR-binding protein 0.0067 0.0161 0.0553
Mycobacterium ulcerans hypothetical protein 0.1028 0.3142 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0109 0.029 0.0643
Schistosoma mansoni organic anion transporter 0.0119 0.032 0.0705
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0437 0.1308 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0067 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0511 0.2719
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0006 0.0008
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0021 0.0112
Onchocerca volvulus 0.0037 0.0067 0.0213
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0197 0.0562 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0067 0.0226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.003 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0007 0.0036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0144 0.0233
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0067 0.0148
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.001 0.0028
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Onchocerca volvulus Putative organic anion transporter 0.0119 0.032 0.1095
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0012 0.0023
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0119 0.032 0.032
Schistosoma mansoni multidrug resistance protein 0.0022 0.0021 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0067 0.0226
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0067 0.0144
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0055 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0345 0.1188
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0303 0.0893 0.6754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0007 0.0036
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0054 0.0054
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0035 0.0303
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0012 0.0012
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0021 0.0156
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0073 0.0177 0.0941
Brugia malayi hypothetical protein 0.0119 0.032 0.1107
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.001 0.0017
Brugia malayi hypothetical protein 0.002 0.0012 0.0036
Echinococcus multilocularis Protein lozenge 0.0118 0.0318 0.0318
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0067 0.0148
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0087 0.0087
Echinococcus multilocularis RUN 0.0042 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.006
Schistosoma mansoni GMP synthetase 0.0035 0.006 0.0128
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Brugia malayi nuclear receptor NHR-67 0.0018 0.0006 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0035 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.007 0.0374
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Onchocerca volvulus 0.0061 0.0141 0.0471
Brugia malayi nuclear receptor RXR 0.0018 0.0006 0.0014
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0007 0.001
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.001 0.0034
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0021 0.0112
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0067 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0067 0.0356
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.001 0.0052
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0021 0.0112
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0035 0.006 0.0408
Schistosoma mansoni hypothetical protein 0.0038 0.007 0.0151
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0162 0.0264
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.007 0.0203
Brugia malayi nuclear hormone receptor 0.0037 0.0067 0.0226
Brugia malayi Cell death protein 3 precursor 0.0063 0.0146 0.0501
Schistosoma mansoni agrin 0.0081 0.0203 0.0446
Loa Loa (eye worm) hypothetical protein 0.0317 0.0936 0.3252
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0073 0.0222
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0067 0.0226
Loa Loa (eye worm) hypothetical protein 0.0081 0.0203 0.0694
Brugia malayi hypothetical protein 0.0042 0.0082 0.0278
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0081 0.0203 0.2127
Echinococcus granulosus cpg binding protein 0.0064 0.0152 0.0337
Echinococcus multilocularis caspase 2 0.0063 0.0146 0.0146
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0102 0.0223
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0006 0.0007
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0006 0.0013
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0087 0.0223 0.3885
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.003
Echinococcus granulosus caspase 8 0.0019 0.001 0.0022

Activities

Activity type Activity value Assay description Source Reference
ID50 (binding) = 8 ug ml-1 Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus ChEMBL. 6157024
ID50 (binding) = 8 ug ml-1 Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus ChEMBL. 6157024

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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