Detailed information for compound 28360

Basic information

Technical information
  • TDR Targets ID: 28360
  • Name: 2-bromo-5,6-dichloro-1-[(4-nitrophenyl)methyl ]benzimidazole
  • MW: 401.042 | Formula: C14H8BrCl2N3O2
  • H donors: 0 H acceptors: 3 LogP: 5.14 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)Cn1c(Br)nc2c1cc(Cl)c(c2)Cl
  • InChi: 1S/C14H8BrCl2N3O2/c15-14-18-12-5-10(16)11(17)6-13(12)19(14)7-8-1-3-9(4-2-8)20(21)22/h1-6H,7H2
  • InChiKey: YONLRMDHVFPVDB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-5,6-dichloro-1-(4-nitrobenzyl)benzimidazole
  • 2-Bromo-5,6-dichloro-1-(4-nitrobenzyl)-1H-benzimidazole
  • AIDS-059428
  • AIDS059428

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Brugia malayi secreted modular calcium-binding protein 1 0.008 0.0236 0.0694
Trypanosoma brucei metacaspase 0.0019 0.0011 0.0012
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0078 0.0319
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0034 0.0102
Brugia malayi Doublecortin family protein 0.0041 0.0095 0.0275
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0065 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0082 0.0371
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0206 0.0384
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0222 0.0754 0.1314
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0008 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0082 0.0155
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0078 0.0224
Echinococcus multilocularis cpg binding protein 0.0064 0.0178 0.0178
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0182 0.0608 0.0608
Onchocerca volvulus 0.0018 0.0008 0.0003
Brugia malayi jmjC domain containing protein 0.0033 0.0065 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0078 0.0078
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.0169 0.0484
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.0011 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0629 0.2855
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0022 0.0024 0.0056
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0619 0.2202 1
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0078 0.0808
Brugia malayi Melibiase family protein 0.0072 0.0206 0.0604
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0008 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0082 0.0318
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0194 0.0654 0.4167
Schistosoma mansoni zinc finger protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0169 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0007 0.0007
Brugia malayi SPARC precursor 0.008 0.0236 0.0694
Loa Loa (eye worm) hypothetical protein 0.0249 0.0851 0.2518
Plasmodium falciparum metacaspase-like protein 0.0019 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0067 0.0188 0.0323
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0337 0.0633
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0085 0.0142
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.0934 0.2771
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0095 0.0576
Brugia malayi CXXC zinc finger family protein 0.0061 0.0165 0.0485
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0747 0.267 0.4677
Schistosoma mansoni rab6-interacting 0.0041 0.0095 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0187 0.0348
Schistosoma mansoni hypothetical protein 0.0103 0.0318 0.0598
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0034 0.0122
Brugia malayi steroid hormone receptor 0.0037 0.0078 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0594 0.2696
Trichomonas vaginalis glutaminase, putative 0.0287 0.0992 0.4506
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0368 0.4167
Brugia malayi Cytochrome P450 family protein 0.0017 0.0004 0.0006
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.0011 0.0016
Brugia malayi beta-lactamase family protein 0.0038 0.0082 0.0236
Schistosoma mansoni follistatin 0.008 0.0236 0.0441
Schistosoma mansoni hypothetical protein 0.0866 0.3104 0.5881
Echinococcus multilocularis muscleblind protein 0.0316 0.1098 0.1098
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0119 0.0347
Schistosoma mansoni transcription factor btf3 0.0037 0.0078 0.0142
Echinococcus multilocularis geminin 0.0178 0.0594 0.0594
Brugia malayi conserved hypotetical protein 0.0017 0.0007 0.0013
Onchocerca volvulus 0.0018 0.0008 0.0003
Brugia malayi jmjC domain containing protein 0.0128 0.0411 0.1214
Entamoeba histolytica P-glycoprotein 5, putative 0.0022 0.0024 0.0076
Loa Loa (eye worm) hypothetical protein 0.0041 0.0095 0.0269
Loa Loa (eye worm) glutaminase 0.0287 0.0992 0.2939
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0078 0.0218
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0194 0.0654 0.2183
Brugia malayi hypothetical protein 0.0043 0.0102 0.0295
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0108 0.0337 0.0638
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0187 0.0542
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0011 0.0025
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.0206 0.0934
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0082 0.0136
Echinococcus granulosus Solute carrier organic anion transporter family 0.0117 0.0371 0.0704
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0065 0.018
Brugia malayi tailless protein 0.0017 0.0007 0.0013
Plasmodium vivax GMP synthetase, putative 0.0035 0.007 0.0956
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0008 0.0006
Onchocerca volvulus 0.0038 0.0082 0.0223
Echinococcus multilocularis dnaJ subfamily B 0.0866 0.3104 0.3104
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0085 0.0142
Onchocerca volvulus 0.0038 0.0082 0.0223
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.0826 0.2755
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0078 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0078 0.0218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0067 0.0188 0.0323
Schistosoma mansoni polycystin 1-related 0.0041 0.0095 0.0174
Loa Loa (eye worm) histone methyltransferase 0.002 0.0016 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Brugia malayi beta-NAC-like protein 0.0037 0.0078 0.0224
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.1092
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0078 0.0224
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0011 0.0056
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.008 0.0236 0.0688
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0078 0.0147
Echinococcus multilocularis agrin 0.008 0.0236 0.0236
Plasmodium vivax multidrug resistance protein 1, putative 0.0022 0.0024 0.0258
Echinococcus granulosus transcription factor btf3 0.0037 0.0078 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.004 0.0503
Echinococcus granulosus cathepsin l1 0.0018 0.0008 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0934 0.4243
Leishmania major cathepsin L-like protease 0.0067 0.0188 0.0323
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0005
Brugia malayi hypothetical protein 0.0026 0.004 0.0113
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0022 0.0024 0.0193
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.1092
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0065 0.0106
Mycobacterium ulcerans hypothetical protein 0.0038 0.0082 0.026
Schistosoma mansoni hypothetical protein 0.0051 0.0129 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0007 0.0013
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Schistosoma mansoni coup transcription factor 0.0037 0.0078 0.0142
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0188 0.0323
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0034 0.0102
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0054 0.0102
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0086 0.0259 0.0844
Trichomonas vaginalis esterase, putative 0.0038 0.0082 0.0371
Trypanosoma cruzi NAD+ synthase, putative 0.0086 0.0259 0.0446
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0108 0.0337 0.0584
Echinococcus granulosus RUN 0.0041 0.0095 0.018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0119 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0194 0.0654 0.7465
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0007 0.0013
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0236 0.2635
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0065 0.0117
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0108 0.0337 0.3809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Mycobacterium ulcerans glutaminase 0.0287 0.0992 0.3322
Schistosoma mansoni loxhd1 0.0041 0.0095 0.0174
Brugia malayi hypothetical protein 0.0019 0.0014 0.0036
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0078 0.0211
Leishmania major p-glycoprotein 0.0022 0.0024 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Schistosoma mansoni nuclear receptor 0.0017 0.0007 0.0007
Onchocerca volvulus 0.0117 0.0371 0.1085
Echinococcus granulosus mitogen activated protein kinase 0.0108 0.0337 0.0639
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0078 0.0211
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0024 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0078 0.0142
Trypanosoma brucei metacaspase MCA2 0.0019 0.0011 0.0012
Schistosoma mansoni multidrug resistance protein 0.0022 0.0024 0.0041
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0302 0.1047 0.6815
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0082 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0007 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0082 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0082 0.0149
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0194 0.0654 0.3961
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0007 0.0007
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0236 0.0694
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Toxoplasma gondii hypothetical protein 0.0255 0.0873 1
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.009
Mycobacterium ulcerans hypothetical protein 0.0831 0.2978 1
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0008 0.0003
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0337 0.0633
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0078 0.0142
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Echinococcus granulosus caspase 8 0.0019 0.0011 0.0022
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.1092
Echinococcus granulosus dnaJ subfamily B 0.0866 0.3104 0.5884
Leishmania major NAD synthase, putative 0.0086 0.0259 0.0446
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0082 0.0149
Entamoeba histolytica hypothetical protein 0.0037 0.0078 0.0319
Echinococcus multilocularis ATP binding cassette sub family B 0.0022 0.0024 0.0024
Brugia malayi Inositol-1 0.0039 0.0085 0.0247
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0078 0.0129
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.004 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0408 0.1201
Brugia malayi hypothetical protein 0.0249 0.0851 0.2522
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0011 0.0058
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0222 0.0754 0.1314
Echinococcus granulosus follistatin 0.008 0.0236 0.0447
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0226 0.0428
Mycobacterium ulcerans beta-lactamase 0.0038 0.0082 0.026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0078 0.0224
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0078 0.0147
Onchocerca volvulus 0.008 0.0236 0.0681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0024 0.0111
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0052 0.0133 0.0246
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0024 0.0024
Echinococcus multilocularis pol protein 0.2755 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0007 0.0013
Brugia malayi nuclear receptor NHR-88 0.0017 0.0007 0.0013
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0065 0.0065
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0188 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0078 0.0224
Leishmania major hypothetical protein, conserved 0.0026 0.004 0.0063
Schistosoma mansoni cpg binding protein 0.0064 0.0178 0.0332
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0008 0.001
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0008 0.0003
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0011 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0078 0.0142
Brugia malayi ecdysone receptor 0.0017 0.0007 0.0013
Echinococcus granulosus agrin 0.008 0.0236 0.0447
Onchocerca volvulus 0.0018 0.0008 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0078 0.0218
Toxoplasma gondii melibiase subfamily protein 0.0108 0.0337 0.38
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0082 0.023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0165 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0078 0.0224
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0129 0.0376
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0065 0.0123
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Schistosoma mansoni hypothetical protein 0.0043 0.0102 0.0187
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0078 0.0129
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0432 0.152 0.509
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0082 0.0371
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0082 0.0249
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.007 0.0242
Trichomonas vaginalis abcb9, putative 0.0022 0.0024 0.0111
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0065 0.0658
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0035 0.007 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0011 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0044 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0078 0.0218
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Brugia malayi jmjC domain containing protein 0.0124 0.0398 0.1176
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0008 0.0008
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Brugia malayi nuclear receptor RXR 0.0019 0.0014 0.0036
Mycobacterium ulcerans GMP synthase 0.0035 0.007 0.0219
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0082 0.0249
Entamoeba histolytica P-glycoprotein-2, putative 0.0022 0.0024 0.0076
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Trypanosoma brucei Metacaspase-4 0.0019 0.0011 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.004 0.0215
Onchocerca volvulus 0.0018 0.0008 0.0003
Echinococcus multilocularis cysteine protease 0.0018 0.0008 0.0008
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0236 0.2635
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0065 0.0123
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0065 0.0065
Brugia malayi prostaglandin transporter 0.0117 0.0371 0.1097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Brugia malayi hypothetical protein 0.0017 0.0006 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0082 0.0249
Echinococcus multilocularis pol protein 0.2755 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0008 0.0016
Onchocerca volvulus 0.0051 0.0129 0.0363
Echinococcus granulosus cpg binding protein 0.0064 0.0178 0.0338
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.0169 0.0316
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Echinococcus multilocularis transcription factor btf3 0.0037 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Loa Loa (eye worm) runx1 0.0118 0.0373 0.1096
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0337 0.0634
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0035 0.007 0.0714
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0078 0.0129
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0167 0.0285
Brugia malayi RNA binding protein 0.0067 0.0187 0.0548
Loa Loa (eye worm) hypothetical protein 0.0938 0.3366 1
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0078 0.0142
Loa Loa (eye worm) hypothetical protein 0.008 0.0236 0.0688
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0432 0.152 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0108 0.0337 0.0337
Brugia malayi TAR-binding protein 0.0067 0.0187 0.0548
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0102 0.0193
Mycobacterium tuberculosis Conserved protein 0.0038 0.0082 0.0249
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0065 0.0106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0034 0.0122
Brugia malayi glutaminase DH11.1 0.0287 0.0992 0.2943
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0086 0.0259 0.3885
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.023
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0065 0.018
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0022 0.0024 0.0045
Onchocerca volvulus 0.0033 0.0063 0.0167
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0086 0.0259 0.1175
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0108 0.0337 0.0584
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0337 0.1532
Schistosoma mansoni jumonji domain containing protein 0.0124 0.0398 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0078 0.0218
Leishmania major basic transcription factor 3a, putative 0.0037 0.0078 0.0129
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0007 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0831 0.2978 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.014 0.0456 0.0864
Loa Loa (eye worm) hypothetical protein 0.0316 0.1098 0.3253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0078 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0078 0.0353
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Echinococcus granulosus microtubule associated protein 2 0.1461 0.5276 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0117 0.0371 0.1092
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0011 0.0012
Echinococcus granulosus caspase 2 0.0062 0.0169 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0078 0.0224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Echinococcus multilocularis pol protein 0.2755 1 1
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0432 0.152 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.004 0.0215
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0411 0.0773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0187 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0078 0.0224
Loa Loa (eye worm) multidrug resistance protein 3 0.0022 0.0024 0.006
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0003 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0016 0.0031
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0121 0.0385 0.0385
Echinococcus multilocularis Protein lozenge 0.0118 0.0373 0.0373
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0024 0.0046
Schistosoma mansoni lipoxygenase 0.0182 0.0608 0.1147
Brugia malayi nuclear receptor RXR 0.0017 0.0007 0.0013
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1578 0.5705 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Echinococcus granulosus geminin 0.0178 0.0594 0.1125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0085 0.0387
Brugia malayi ABC transporter family protein 0.0022 0.0024 0.0066
Plasmodium vivax JmjC domain containing protein 0.0033 0.0065 0.0882
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0108 0.0337 0.0584
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0011 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0078 0.0142
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0136 0.0231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0022 0.0024 0.0086
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0057
Echinococcus multilocularis expressed protein 0.008 0.0236 0.0236
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0302 0.1047 0.3505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0226 0.0226
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0035 0.007 0.007
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Schistosoma mansoni lipoxygenase 0.0107 0.0336 0.0631
Brugia malayi sodium-independent organic anion transporter family protein 0.0117 0.0371 0.1097
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0078 0.0142
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0174
Onchocerca volvulus 0.0025 0.0034 0.0083
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0085 0.0387
Treponema pallidum fructose-bisphosphate aldolase 0.0619 0.2202 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0034 0.009
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0082 0.0249
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0095 0.0095
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0078 0.0147
Leishmania major hypothetical protein, conserved 0.0038 0.0082 0.0136
Onchocerca volvulus 0.0022 0.0024 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0102
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.007 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0007 0.0007
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0065 0.0123
Mycobacterium leprae Probable lipase LipE 0.0038 0.0082 0.0318
Brugia malayi nuclear receptor NHR-67 0.0017 0.0007 0.0013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0222 0.0754 0.1314
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0337 0.1532
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0095 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Echinococcus granulosus tar DNA binding protein 0.0067 0.0187 0.0354
Entamoeba histolytica hypothetical protein 0.0038 0.0082 0.0336
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0053
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0108 0.0337 0.099
Onchocerca volvulus 0.0041 0.0095 0.0262
Trichomonas vaginalis hypothetical protein 0.0194 0.0654 0.2968
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0629 0.2855
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.003
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0078 0.0353
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0432 0.152 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0007 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0102
Entamoeba histolytica P-glycoprotein-5 0.0022 0.0024 0.0076
Brugia malayi beta-lactamase 0.0038 0.0082 0.0236
Brugia malayi hypothetical protein 0.0938 0.3366 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0078 0.0224
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0007 0.0007
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0117 0.0371 0.0371
Schistosoma mansoni inositol monophosphatase 0.0039 0.0085 0.0156
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0007 0.0007
Mycobacterium ulcerans lipase LipD 0.0038 0.0082 0.026
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0078 0.0142
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0077 0.0147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.023
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0011 0.0042
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0003 0.0005
Brugia malayi Cytochrome P450 family protein 0.0027 0.0044 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0024 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.009
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.1092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) DR-78 0.0017 0.0007 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0108 0.0337 0.0584
Entamoeba histolytica hypothetical protein 0.0038 0.0082 0.0336
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0182 0.0608 0.1152
Trypanosoma cruzi metacaspase, putative 0.0019 0.0011 0.0012
Plasmodium falciparum metacaspase 1 0.0019 0.0011 0.0024
Echinococcus granulosus muscleblind protein 0.0316 0.1098 0.2081
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0594 0.2696
Echinococcus multilocularis mitogen activated protein kinase 0.0108 0.0337 0.0337
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0078 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0082 0.0136
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0034 0.009
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0065 0.0658
Entamoeba histolytica NAD synthetase, putative 0.0086 0.0259 0.1143
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0078 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0337 0.1532
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0082 0.0236
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0008 0.0009
Onchocerca volvulus 0.0018 0.0008 0.0003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1578 0.5705 1
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.0011 0.0016
Toxoplasma gondii protease inhibitor PI2 0.008 0.0236 0.2635
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.014 0.0456 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0063 0.0114
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0065 0.0117
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0747 0.267 0.4677
Mycobacterium ulcerans hypothetical protein 0.0025 0.0034 0.0102
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0022 0.0024 0.0035
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0006
Giardia lamblia Kinase, CMGC MAPK 0.0108 0.0337 0.0405
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0432 0.152 0.649
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0187 0.0348
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0014 0.0022
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0095 0.0095
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.0934 0.2766
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.023
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0086 0.0259 0.29
Schistosoma mansoni organic anion transporter 0.0117 0.0371 0.0699
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0085 0.0162
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0082 0.0149
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0043 0.0102 0.0289
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0337 0.0633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0119 0.0226
Brugia malayi jmjC domain containing protein 0.0033 0.0065 0.0186
Schistosoma mansoni hypothetical protein 0.0178 0.0594 0.112
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0065 0.0377
Loa Loa (eye worm) agrin synaptic family protein 0.008 0.0236 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Leishmania major mitochondrial DNA polymerase beta 0.1578 0.5705 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.008 0.0236 0.0688
Brugia malayi sodium-independent organic anion transporter family protein 0.0117 0.0371 0.1097
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Echinococcus multilocularis lysine specific demethylase 5A 0.0124 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0041 0.0095 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0078 0.0218
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0007 0.0007
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0117 0.0371 0.0371
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0053
Mycobacterium tuberculosis Conserved protein 0.0038 0.0082 0.0249
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1578 0.5705 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0218
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.006
Schistosoma mansoni hypothetical protein 0.0041 0.0095 0.0174
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0078 0.0224
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0194 0.0654 0.4256
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.0594 0.1747
Schistosoma mansoni survival motor neuron protein 0.0051 0.0129 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0594 0.2696
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0411 0.0773
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.027 0.0931 0.1625
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Schistosoma mansoni microtubule-associated protein tau 0.1461 0.5276 1
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0078 0.0147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0063 0.0637
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0085 0.0353
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.023
Toxoplasma gondii ABC1 family protein 0.0038 0.0082 0.0854
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0188 0.0323
Brugia malayi Pre-SET motif family protein 0.022 0.0747 0.2213
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0082 0.0136
Brugia malayi multidrug resistance protein 3 0.0022 0.0024 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0082 0.0371
Leishmania major metacaspase, putative 0.0019 0.0011 0.0012
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.0851 0.0851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0078 0.0218
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0085 0.0896
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0011 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0007 0.0013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0082 0.0249
Loa Loa (eye worm) RNA binding protein 0.0067 0.0187 0.0542
Loa Loa (eye worm) beta-lactamase 0.0038 0.0082 0.023
Onchocerca volvulus 0.0041 0.0095 0.0262
Brugia malayi MAP kinase sur-1 0.0108 0.0337 0.0996
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0236 0.2635
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0108 0.0337 0.0584
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0187 0.0187
Onchocerca volvulus 0.0938 0.3366 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0194 0.0654 1
Trypanosoma cruzi MFS transporter, putative 0.0117 0.0371 0.0644
Brugia malayi jmjC domain containing protein 0.0033 0.0065 0.0186
Schistosoma mansoni nuclear receptor 0.0017 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Trichomonas vaginalis set domain proteins, putative 0.025 0.0857 0.3893
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0095 0.0269
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0065 0.0106
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0078 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Loa Loa (eye worm) inositol-1 0.0039 0.0085 0.0241
Plasmodium falciparum multidrug resistance protein 1 0.0022 0.0024 0.011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0016 0.0016
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0022 0.0024 0.006
Schistosoma mansoni lozenge 0.0118 0.0373 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0078 0.0224
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0078 0.0142
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0034 0.0102
Schistosoma mansoni cpg binding protein 0.0061 0.0165 0.0308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0078 0.0147
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0011 0.0011
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Brugia malayi hypothetical protein 0.0117 0.0371 0.1097
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0594 0.2696
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Entamoeba histolytica P-glyco protein 6, putative 0.0022 0.0024 0.0076
Onchocerca volvulus 0.0037 0.0078 0.0211
Plasmodium falciparum enoyl-acyl carrier reductase 0.0194 0.0654 0.427
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0078 0.0224
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.0337 0.1532
Toxoplasma gondii transporter, major facilitator family protein 0.0117 0.0371 0.4204
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0078 0.0078
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0432 0.152 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.004 0.0375
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0008 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0082 0.0371
Onchocerca volvulus 0.0061 0.0165 0.0472
Onchocerca volvulus 0.0018 0.0008 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni GMP synthetase 0.0035 0.007 0.0126
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Plasmodium vivax metacaspase 1, putative 0.0019 0.0011 0.0056
Loa Loa (eye worm) hypothetical protein 0.0072 0.0206 0.0599
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0024 0.0046
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0117 0.0371 0.0704
Echinococcus granulosus caspase 0.0019 0.0011 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0016 0.0039
Brugia malayi sodium-independent organic anion transporter family protein 0.0117 0.0371 0.1097
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0078 0.0147
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0102 0.0102
Echinococcus multilocularis RUN 0.0041 0.0095 0.0095
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0063 0.0114
Brugia malayi MH2 domain containing protein 0.0127 0.0408 0.1206
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0007 0.0013
Schistosoma mansoni glutaminase 0.0287 0.0992 0.1876
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0063 0.0063
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0063
Loa Loa (eye worm) hypothetical protein 0.008 0.0236 0.0688
Brugia malayi hypothetical protein 0.0041 0.0095 0.0275
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.008 0.0236 0.2635
Schistosoma mansoni cpg binding protein 0.0064 0.0178 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Echinococcus multilocularis caspase 2 0.0062 0.0169 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0119 0.022
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0086 0.0259 0.1509
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0007 0.0013
Brugia malayi hypothetical protein 0.0019 0.0014 0.0036
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0014 0.0027
Brugia malayi nuclear hormone receptor 0.0037 0.0078 0.0224
Brugia malayi Cell death protein 3 precursor 0.0062 0.0169 0.0497
Schistosoma mansoni agrin 0.008 0.0236 0.0441
Brugia malayi Muscleblind-like protein 0.0316 0.1098 0.3257
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0085 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0078 0.0224
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0035 0.007 0.0408
Trichomonas vaginalis abcb9, putative 0.0022 0.0024 0.0111
Schistosoma mansoni hypothetical protein 0.0038 0.0082 0.0149
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0082 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0187 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0078 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0078 0.0353
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0014 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0078 0.0078
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0086 0.0259 0.1659
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0035 0.007 0.0114
Trypanosoma brucei protein kinase, putative 0.0108 0.0337 0.0584
Echinococcus granulosus mitogen activated protein kinase 3 0.0108 0.0337 0.0639
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0078 0.0078
Brugia malayi nuclear receptor NHR-88 0.0037 0.0078 0.0224
Mycobacterium tuberculosis Conserved protein 0.0038 0.0082 0.0249
Trypanosoma brucei NAD+ synthase, putative 0.0086 0.0259 0.0446
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0007 0.0013
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0086 0.0259 0.0485
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0934 0.4243
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.1092
Onchocerca volvulus 0.0038 0.0082 0.0223
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0934 0.4243
Schistosoma mansoni inositol monophosphatase 0.0039 0.0085 0.0156
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0236 0.0694
Entamoeba histolytica P-glycoprotein-2 0.0022 0.0024 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Onchocerca volvulus 0.0018 0.0008 0.0003
Onchocerca volvulus Putative organic anion transporter 0.0117 0.0371 0.1085
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0007 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0014 0.0022
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0206 0.0384
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0078 0.0224
Onchocerca volvulus 0.0117 0.0371 0.1085
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0034 0.0053
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0016
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0085 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0119 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0188 0.0323
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0108 0.0337 0.0584
Brugia malayi Cytochrome P450 family protein 0.0017 0.0004 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0078 0.0224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0119 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Brugia malayi jmjC domain containing protein 0.0033 0.0065 0.0186
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0082 0.026
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0008 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0078 0.0142
Entamoeba histolytica P-glycoprotein-1 0.0022 0.0024 0.0076
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0022 0.0024 0.0193
Echinococcus multilocularis cysteine protease 0.0018 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0119 0.0119
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0095 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Brugia malayi GMP synthase 0.0035 0.007 0.02
Loa Loa (eye worm) fibroinase 0.0018 0.0008 0.001
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Onchocerca volvulus Putative organic anion transporter 0.0117 0.0371 0.1085
Brugia malayi hypothetical protein 0.0117 0.0371 0.1097
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0034 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0078 0.0224
Echinococcus multilocularis mitogen activated protein kinase 3 0.0108 0.0337 0.0337
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0934 0.4243
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0108 0.0337 0.0337
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0063 0.0119
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0014 0.0014
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0108 0.0337 0.0633
Giardia lamblia Fructose-bisphosphate aldolase 0.0619 0.2202 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0108 0.0337 0.0584
Echinococcus multilocularis microtubule associated protein 2 0.1461 0.5276 0.5276
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0034 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Brugia malayi nuclear hormone receptor 0.0017 0.0007 0.0013
Loa Loa (eye worm) cysteine protease 0.0018 0.0008 0.001
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0065 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0096
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis caspase 8 0.0019 0.0011 0.0011
Schistosoma mansoni smdr2 0.0022 0.0024 0.0041
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0078 0.1082
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0007 0.0007
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0022 0.0024 0.0111
Echinococcus multilocularis caspase 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0117 0.0371 0.1085
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Trypanosoma brucei metacaspase MCA3 0.0019 0.0011 0.0012
Loa Loa (eye worm) glutaminase 2 0.0287 0.0992 0.2939
Brugia malayi Pre-SET motif family protein 0.0033 0.0063 0.018
Onchocerca volvulus 0.0117 0.0371 0.1085
Brugia malayi ecdysteroid receptor 0.0037 0.0078 0.0224
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0078 0.0142
Brugia malayi beta-lactamase family protein 0.0038 0.0082 0.0236
Onchocerca volvulus 0.0043 0.0102 0.0282
Echinococcus multilocularis muscleblind protein 1 0.0316 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0065 0.018
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0008 0.0003
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0008 0.0008
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0007 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0408 0.1201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.023
Mycobacterium ulcerans NAD synthetase 0.0086 0.0259 0.0855
Schistosoma mansoni multidrug resistance protein 0.0022 0.0024 0.0041
Echinococcus granulosus phd:f box containing protein 0.0033 0.0065 0.0123
Brugia malayi hypothetical protein 0.0038 0.0082 0.0236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0082 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0008 0.0035
Entamoeba histolytica hypothetical protein 0.0038 0.0082 0.0336
Brugia malayi hypothetical protein 0.0041 0.0095 0.0275
Trypanosoma cruzi NAD+ synthase, putative 0.0086 0.0259 0.0446
Onchocerca volvulus 0.025 0.0858 0.2533
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0747 0.2209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0302 0.1047 0.3498
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0187 0.0548
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0078 0.0078
Echinococcus multilocularis follistatin 0.008 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0178 0.0594 0.112
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0194 0.0654 0.2174
Plasmodium vivax SET domain protein, putative 0.0033 0.0063 0.0854
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0063 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0594 0.2696
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0011 0.0052
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0065 0.0117
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0085 0.0387
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0078 0.0078
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0934 0.4243
Onchocerca volvulus Putative organic anion transporter 0.0117 0.0371 0.1085
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0432 0.152 0.5096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0418 0.0788
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0065 0.018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0078 0.0078
Leishmania major hypothetical protein, conserved 0.0033 0.0065 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0082 0.1144
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0035
Schistosoma mansoni multidrug resistance protein 0.0022 0.0024 0.0041
Trichomonas vaginalis abcb9, putative 0.0022 0.0024 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.001
Schistosoma mansoni organic anion transporter 0.0117 0.0371 0.0699
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.1092
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0007 0.0007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0011 0.0052
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0022 0.0024 0.0046
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0236 0.0694
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0022 0.0024 0.0111
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0095 0.018
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0022 0.0024 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0078 0.0147
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0747 0.267 0.4677
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0594 0.2696
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.008 0.0236 0.0694
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0011 0.0042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0085 0.0142
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.0411 0.0778
Trichomonas vaginalis ABC transporter, putative 0.0022 0.0024 0.0111
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0095 0.1348
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0078 0.0211
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0082 0.0371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0188 0.0323
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0124 0.0398 0.0398
Onchocerca volvulus 0.0117 0.0371 0.1085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.023
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0035 0.007 0.0114
Loa Loa (eye worm) hypothetical protein 0.0316 0.1098 0.3253
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0034 0.0122
Trichomonas vaginalis taga, putative 0.0022 0.0024 0.0111
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0124 0.0398 0.0754
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0594 0.2696
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0187 0.0542
Schistosoma mansoni rab6-interacting 0.0041 0.0095 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Entamoeba histolytica hypothetical protein 0.0038 0.0082 0.0336
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0934 0.4243
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0065 0.0065
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0022 0.0024 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0119 0.0226
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0222 0.0754 0.1314
Loa Loa (eye worm) hypothetical protein 0.008 0.0236 0.0688
Loa Loa (eye worm) hypothetical protein 0.0938 0.3366 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0619 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.0371 0.1092
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.0411 0.1209
Trypanosoma brucei RNA helicase, putative 0.0103 0.0318 0.055
Loa Loa (eye worm) ctsf protein 0.0018 0.0008 0.001
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.0851 0.1612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0035
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0008 0.0015
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0077 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0619 0.2202 1
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0082 0.026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0078 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0063 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0187 0.0348
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0082 0.0249
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0096
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0007 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.0096

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6.9 uM Compound was tested for antiviral activity against matched pairs of HIV-1 resistant to AZT ChEMBL. 9548815
IC50 (functional) = 11 uM Compound was tested for antiviral activity against matched pairs of HIV-1 sensitive to AZT ChEMBL. 9548815
IC50 (functional) = 11 uM Compound was tested for antiviral activity against HIV resistant to TIBO A-17 ChEMBL. 9548815
IC50 (functional) = 14 uM Activity against HIV-1 by syncytial plaque assay performed in duplicate using CEM-SS cells ChEMBL. 9548815
IC50 (functional) = 40 uM Inhibition of KB cell growth determined by quadruplicate assays ChEMBL. 9548815
IC50 (functional) = 40 uM Inhibition of KB cell growth determined by quadruplicate assays ChEMBL. 9548815
IC50 (functional) = 66 uM Compound was tested for antiviral activity against HIV-2 ChEMBL. 9548815
IC50 (functional) > 100 uM Antiviral activity against human cytomegalovirus(HCMV) by plaque reduction assay ChEMBL. 9548815
IC50 (functional) > 100 uM Visual cytotoxicity scored on HFF cells at a time of HCMV plaque enumeration ChEMBL. 9548815
IC50 (functional) > 100 uM Cytotoxicity against CEM-SS cells in terms of incorporation of [3H]-dThd ChEMBL. 9548815
IC50 (functional) > 100 uM Visual cytotoxicity scored on HFF cells at a time of HCMV plaque enumeration ChEMBL. 9548815
IC50 (functional) > 100 uM Cytotoxicity against CEM-SS cells in terms of incorporation of [3H]-dThd ChEMBL. 9548815

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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