Detailed information for compound 28647

Basic information

Technical information
  • TDR Targets ID: 28647
  • Name: [5-(6-aminopurin-9-yl)-3-fluorooxolan-2-yl]me thanol
  • MW: 253.233 | Formula: C10H12FN5O2
  • H donors: 2 H acceptors: 4 LogP: -0.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1F)n1cnc2c1ncnc2N
  • InChi: 1S/C10H12FN5O2/c11-5-1-7(18-6(5)2-17)16-4-15-8-9(12)13-3-14-10(8)16/h3-7,17H,1-2H2,(H2,12,13,14)
  • InChiKey: CTDUJDNZPPZTAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(6-aminopurin-9-yl)-3-fluoro-tetrahydrofuran-2-yl]methanol
  • [5-(6-aminopurin-9-yl)-3-fluoro-2-tetrahydrofuranyl]methanol
  • [5-(6-aminopurin-9-yl)-3-fluoro-oxolan-2-yl]methanol
  • (5-adenin-9-yl-3-fluoro-tetrahydrofuran-2-yl)methanol
  • [5-(6-amino-9-purinyl)-3-fluoro-2-tetrahydrofuranyl]methanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin 0.0056 0.0307 0.0289
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Schistosoma mansoni DNA polymerase eta 0.008 0.0532 0.0515
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis dna polymerase kappa 0.0081 0.0544 0.0527
Brugia malayi Pre-SET motif family protein 0.0426 0.3908 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1359 0.1343
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Onchocerca volvulus 0.0095 0.0683 0.1491
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.0694 0.0678
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0033 0.0075 0.0057
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0105 0.0216
Trypanosoma brucei glucosidase, putative 0.0036 0.0112 0.0676
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0033 0.0075 0.0057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0033 0.0075 0.0191
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0045 0.004
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0148 0.0191
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0044 0.0184 0.119
Loa Loa (eye worm) hypothetical protein 0.004 0.0148 0.0304
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0562 0.0545
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 0.2043
Echinococcus multilocularis nAChR subunit 0.0033 0.0075 0.0057
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Loa Loa (eye worm) hypothetical protein 0.0088 0.0616 0.1262
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0053 0.0271 0.0253
Echinococcus multilocularis lysine specific demethylase 6a 0.0051 0.025 0.0232
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0044 0.0184 0.0186
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0467 0.045
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0044 0.0184 0.119
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.0075 0.0057
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Onchocerca volvulus 0.0104 0.0771 0.1687
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0097 0.0567
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0053 0.0271 0.0371
Loa Loa (eye worm) jmjC domain-containing protein 0.0195 0.166 0.3402
Brugia malayi Heterochromatin protein 1 0.007 0.0442 0.113
Schistosoma mansoni jun-related protein 0.0071 0.0445 0.0428
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0112 0.0094
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0218 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0148 0.013
Loa Loa (eye worm) hypothetical protein 0.008 0.0532 0.1091
Schistosoma mansoni chromobox protein 0.007 0.0442 0.0424
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0112 0.0138
Trypanosoma brucei unspecified product 0.0037 0.0119 0.0728
Brugia malayi CXXC zinc finger family protein 0.0029 0.0039 0.01
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0307 0.0784
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.0603 0.0586
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0359 0.0341
Entamoeba histolytica steroid 5-alpha reductase, putative 0.017 0.1411 0.2043
Schistosoma mansoni protein phosphatase 2C 0.0051 0.025 0.0232
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.017 0.1411 1
Brugia malayi bZIP transcription factor family protein 0.0087 0.0603 0.1544
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0204
Loa Loa (eye worm) hypothetical protein 0.0053 0.0271 0.0555
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0148 0.0151
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0348 0.037
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0053 0.0271 0.0253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Echinococcus multilocularis jumonji domain containing 1A 0.0051 0.025 0.0232
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.0075 0.0057
Brugia malayi PAS domain containing protein 0.0061 0.0355 0.0907
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0044 0.0184 0.119
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0764 0.0747
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0097 0.028
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Treponema pallidum ATP-dependent RNA helicase 0.0053 0.0271 0.0332
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0526 0.4881 0.5452
Plasmodium falciparum eukaryotic initiation factor 4A 0.0053 0.0271 0.7746
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0112 0.0094
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0044 0.0184 0.119
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0097 0.0378
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0033 0.0075 0.0191
Loa Loa (eye worm) hypothetical protein 0.0051 0.025 0.0512
Brugia malayi Melibiase family protein 0.0069 0.0428 0.1096
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Schistosoma mansoni cpg binding protein 0.0029 0.0039 0.0021
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0148 0.0659
Giardia lamblia Fructose-bisphosphate aldolase 0.0727 0.6836 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0053 0.0271 0.1566
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0428 0.0411
Loa Loa (eye worm) hypothetical protein 0.0104 0.0771 0.1579
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Echinococcus granulosus lysine specific demethylase 5A 0.0195 0.166 0.1645
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Echinococcus multilocularis musashi 0.0056 0.0307 0.0289
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0044 0.0184 0.0922
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0238 0.022
Brugia malayi Cation transporter family protein 0.0104 0.0771 0.1972
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0544 0.3778
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0022 0.0004
Schistosoma mansoni phosphatidylserine receptor 0.0051 0.025 0.0232
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0044 0.0184 0.0371
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0104 0.0771 0.0754
Brugia malayi Bromodomain containing protein 0.0064 0.0383 0.0981
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0283 0.0297
Schistosoma mansoni alpha-glucosidase 0.0142 0.1135 0.112
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 0.2043
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Schistosoma mansoni cpg binding protein 0.0035 0.0093 0.0075
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0307 0.0628
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0053 0.0271 0.0253
Mycobacterium ulcerans putative regulatory protein 0.0045 0.0199 0.0203
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0825 0.5796
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0044 0.0184 0.0166
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0336 0.0689
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0112 0.0676
Brugia malayi mbt repeat family protein 0.0049 0.0238 0.0608
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0376
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.3908 0.8007
Loa Loa (eye worm) hypothetical protein 0.0149 0.1204 0.2467
Loa Loa (eye worm) hypothetical protein 0.0526 0.4881 1
Trypanosoma brucei unspecified product 0.0074 0.0479 0.3312
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.0694 0.0678
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0825 0.0905
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0357 0.034
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0044 0.0184 0.119
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 1
Loa Loa (eye worm) MBCTL1 0.0056 0.0304 0.0623
Echinococcus multilocularis aryl hydrocarbon receptor 0.0133 0.1048 0.1032
Echinococcus granulosus muscleblind protein 0.0149 0.1204 0.1188
Leishmania major hypothetical protein, conserved 0.0044 0.0184 0.0922
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Echinococcus granulosus chromobox protein 1 0.007 0.0442 0.0424
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0033 0.0075 0.0191
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0825 0.5669
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.0075 0.0057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.0953 0.0937
Loa Loa (eye worm) phosphofructokinase 0.011 0.0825 0.1691
Onchocerca volvulus 0.0033 0.0075 0.0127
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0238 0.022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0097 0.0567
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.1359 0.2784
Loa Loa (eye worm) hypothetical protein 0.0083 0.0562 0.1152
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0313 0.2804 0.2791
Trichomonas vaginalis chromobox protein, putative 0.0042 0.017 0.0223
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0051 0.025 0.1665
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0033 0.0075 0.0191
Schistosoma mansoni hypothetical protein 0.0031 0.0059 0.0041
Loa Loa (eye worm) hypothetical protein 0.0083 0.0562 0.1152
Loa Loa (eye worm) hypothetical protein 0.0089 0.0624 0.1278
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Schistosoma mansoni hypothetical protein 0.0042 0.0165 0.0147
Onchocerca volvulus 0.0104 0.0771 0.1687
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0051 0.025 0.1498
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.0603 0.0586
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0092 0.0235
Onchocerca volvulus Alhambra homolog 0.006 0.0336 0.0714
Echinococcus granulosus peregrin 0.0064 0.0383 0.0366
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0942 0.8937 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0825 0.1149
Echinococcus multilocularis peregrin 0.0064 0.0383 0.0366
Brugia malayi Cation transporter family protein 0.0033 0.0075 0.0191
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Brugia malayi RE18450p 0.0044 0.0184 0.047
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0044 0.0184 0.119
Schistosoma mansoni microtubule-associated protein tau 0.075 0.7063 0.7057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis microtubule associated protein 2 0.075 0.7063 0.7057
Echinococcus granulosus expressed protein 0.0036 0.0105 0.0087
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0033 0.0075 0.0057
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0336 0.0319
Plasmodium vivax JmjC domain containing protein 0.0051 0.025 0.6557
Brugia malayi Bromodomain containing protein 0.0154 0.1256 0.3213
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0825 0.1184
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0054 0.0283 0.0265
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0825 0.1691
Onchocerca volvulus 0.0132 0.1043 0.2297
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0053 0.0271 0.0567
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0044 0.0184 0.119
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.0075 0.0057
Plasmodium vivax hypothetical protein, conserved 0.006 0.0336 0.933
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0044 0.0184 0.047
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0148 0.013
Leishmania major hypothetical protein, conserved 0.0051 0.025 0.1412
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1204 0.1188
Loa Loa (eye worm) hypothetical protein 0.0044 0.0184 0.0376
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0027 0.0018 0.0037
Brugia malayi PHD-finger family protein 0.006 0.0336 0.0861
Loa Loa (eye worm) hypothetical protein 0.0044 0.0184 0.0376
Echinococcus multilocularis nmda type glutamate receptor 0.0133 0.1052 0.1036
Onchocerca volvulus Putative fad oxidoreductase 0.0044 0.0184 0.0371
Schistosoma mansoni jumonji domain containing protein 0.0051 0.025 0.0232
Onchocerca volvulus 0.0046 0.0204 0.0418
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0825 0.1691
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0045 0.004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0195 0.166 0.1645
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0825 0.0809
Loa Loa (eye worm) hypothetical protein 0.0049 0.0238 0.0487
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.0532 0.3693
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0942 0.8937 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0238 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.018
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0051 0.0105
Trypanosoma brucei DNA polymerase IV, putative 0.0074 0.0479 0.3312
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0075 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0044 0.0184 0.0186
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0044 0.0184 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0544 0.059
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0033 0.0075 0.0057
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0033 0.0075 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0825 0.5796
Onchocerca volvulus 0.0033 0.0075 0.0127
Onchocerca volvulus Putative nachr subunit 0.0033 0.0075 0.0127
Trichomonas vaginalis chromobox protein, putative 0.007 0.0442 0.0621
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.0075 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0053 0.0271 0.1651
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0038 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0184 0.1194
Echinococcus granulosus eukaryotic initiation factor 4A 0.0053 0.0271 0.0253
Onchocerca volvulus 0.0083 0.0562 0.1219
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.025 0.0512
Loa Loa (eye worm) hypothetical protein 0.0051 0.025 0.0512
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0469 0.0452
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.025 0.0512
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.1359 0.3477
Schistosoma mansoni jumonji domain containing protein 0.0273 0.2413 0.24
Schistosoma mansoni hypothetical protein 0.006 0.0336 0.0319
Trichomonas vaginalis rotamase, putative 0.0036 0.0105 0.0128
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0287
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0044 0.0184 0.119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.017 0.1411 0.3611
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0075 0.0191
Loa Loa (eye worm) hypothetical protein 0.0104 0.0771 0.1579
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0148 0.0934
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0053 0.0271 0.0283
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0562 0.1438
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0053 0.0277 0.0259
Trypanosoma cruzi ISWI complex protein 0.0031 0.0059 0.0295
Echinococcus granulosus nmda type glutamate receptor 0.0087 0.0607 0.059
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0348 0.2134
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0033 0.0075 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Toxoplasma gondii hypothetical protein 0.0044 0.0184 0.1013
Echinococcus multilocularis lysine specific demethylase 5A 0.019 0.1606 0.1591
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.025 0.0512
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0304 0.0287
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0106 0.0217
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0359 0.0382
Schistosoma mansoni hypothetical protein 0.0071 0.0445 0.0428
Onchocerca volvulus 0.0056 0.0307 0.0647
Brugia malayi eukaryotic initiation factor 4A 0.0053 0.0271 0.0693
Schistosoma mansoni lamin 0.0056 0.0307 0.0289
Loa Loa (eye worm) hypothetical protein 0.0069 0.0428 0.0877
Schistosoma mansoni chromobox protein 0.007 0.0442 0.0424
Echinococcus granulosus JmjC domain containing protein 4 0.0051 0.025 0.0232
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0044 0.0184 0.0166
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0112 0.0392
Brugia malayi Aldehyde dehydrogenase protein 4 0.0027 0.0018 0.0046
Chlamydia trachomatis D-amino acid dehydrogenase 0.0044 0.0184 1
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0336 0.2131
Brugia malayi polk-prov protein 0.0044 0.0181 0.0464
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0094 0.0076
Echinococcus multilocularis muscleblind protein 0.0149 0.1204 0.1188
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0033 0.0075 0.0191
Schistosoma mansoni glutamate receptor NMDA 0.0102 0.0753 0.0736
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1818
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Echinococcus multilocularis glutamate receptor NMDA 0.008 0.0532 0.0515
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0056 0.0304 0.0286
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0428 0.0411
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0053 0.0271 0.0332
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.0544 0.0772
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0056 0.0307 0.0628
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0051 0.025 0.1665
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0165 0.0337
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0033 0.0075 0.0057
Echinococcus multilocularis JmjC domain containing protein 4 0.0051 0.025 0.0232
Echinococcus multilocularis nmda type glutamate receptor 0.0087 0.0607 0.059
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0022 0.0004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0112 0.0138
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0304 0.0287
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0131 0.0126
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0764 0.0747
Echinococcus multilocularis zinc finger protein 0.0041 0.016 0.0142
Schistosoma mansoni hypothetical protein 0.0304 0.2718 0.2705
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0148 0.013
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0116 0.0887 0.2271
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0148 0.0934
Schistosoma mansoni fad oxidoreductase 0.0044 0.0184 0.0166
Brugia malayi 6-phosphofructokinase 0.011 0.0825 0.2112
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0112 0.0138
Echinococcus granulosus dna polymerase eta 0.008 0.0532 0.0515
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0044 0.0184 0.4435
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0141 0.018
Echinococcus multilocularis lamin dm0 0.0056 0.0307 0.0289
Schistosoma mansoni hypothetical protein 0.1052 1 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0283 0.0579
Onchocerca volvulus 0.0056 0.0307 0.0647
Schistosoma mansoni cpg binding protein 0.0035 0.0093 0.0075
Echinococcus multilocularis jun protein 0.0087 0.0603 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0184 0.1194
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0359 0.0382
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0181 0.1173
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0053 0.0271 0.1815
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0033 0.0075 0.0057
Giardia lamblia DINP protein human, muc B family 0.0061 0.0348 0.0445
Schistosoma mansoni jumonji/arid domain-containing protein 0.0195 0.166 0.1645
Echinococcus multilocularis dna polymerase eta 0.008 0.0532 0.0515
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0377 0.036
Schistosoma mansoni zinc finger protein 0.0031 0.0059 0.0041
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0148 0.0934
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0054 0.0283 0.0265
Giardia lamblia PHD finger protein 15 0.006 0.0336 0.0429
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0044 0.0184 0.0186
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0112 0.023
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0764 0.0747
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Onchocerca volvulus 0.0073 0.0469 0.1012
Echinococcus granulosus dna polymerase kappa 0.0081 0.0544 0.0527
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0033 0.0075 0.0057
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0097 0.0116
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0467 0.045
Onchocerca volvulus 0.0049 0.0238 0.0492
Mycobacterium ulcerans hypothetical protein 0.017 0.1411 0.1562
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0097 0.0567
Echinococcus granulosus microtubule associated protein 2 0.075 0.7063 0.7057
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0562 0.0545
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0044 0.0184 0.047
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0112 0.0676
Leishmania major hypothetical protein, conserved 0.0044 0.0184 0.0922
Brugia malayi jmjC domain containing protein 0.0195 0.166 0.4249
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0825 0.1184
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0727 0.6836 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.017 0.034
Trichomonas vaginalis chromobox protein, putative 0.007 0.0442 0.0621
Brugia malayi chromobox protein homolog 3 0.0039 0.0141 0.036
Onchocerca volvulus 0.0031 0.0058 0.0089
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0304 0.0778
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0112 0.0489
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0336 0.0319
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Brugia malayi jmjC domain containing protein 0.0313 0.2804 0.7174
Schistosoma mansoni zinc finger protein 0.0041 0.016 0.0142
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0053 0.0271 0.0371
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0105 0.0269
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.0075 0.0057
Entamoeba histolytica deoxycytidyl transferase, putative 0.0054 0.0283 0.0388
Loa Loa (eye worm) hypothetical protein 0.0055 0.0296 0.0607
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0181 0.1173
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Echinococcus granulosus glutamate receptor NMDA 0.008 0.0532 0.0515
Schistosoma mansoni rotamase 0.0036 0.0105 0.0087
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0104 0.0771 0.0754
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Trichomonas vaginalis chromobox protein, putative 0.0042 0.017 0.0223
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0112 0.0138
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0045
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0112 0.0138
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0044 0.0184 0.0243
Schistosoma mansoni NAD dehydrogenase 0.0044 0.0184 0.0166
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0033 0.0075 0.0153
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0024
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0238 0.0492
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0112 0.0287
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Brugia malayi bHLH-PAS transcription factor 0.0045 0.0199 0.051
Loa Loa (eye worm) hypothetical protein 0.0133 0.1057 0.2165
Onchocerca volvulus 0.0033 0.0075 0.0127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0094 0.0076
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0238 0.022
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0051 0.0131
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0044 0.0184 0.0186
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0238 0.022
Echinococcus granulosus jumonji domain containing 1A 0.0051 0.025 0.0232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus granulosus phd:f box containing protein 0.0051 0.025 0.0232
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0482 0.4453 0.4973
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0033 0.0075 0.0153
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0033 0.0075 0.0057
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0044 0.0184 0.119
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0118
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1689 0.1674
Trypanosoma brucei DNA polymerase eta, putative 0.008 0.0532 0.3693
Leishmania major eukaryotic initiation factor 4a, putative 0.0053 0.0271 0.1566
Loa Loa (eye worm) hypothetical protein 0.0132 0.1043 0.2137
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0825 0.0905
Loa Loa (eye worm) LGC-31 protein 0.0033 0.0075 0.0153
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0033 0.0075 0.0153
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0051 0.025 0.0232
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0218 0.0201
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0336 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Chlamydia trachomatis glutamine binding protein 0.0038 0.0131 0.6188
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0166
Loa Loa (eye worm) hypothetical protein 0.0085 0.058 0.1189
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0051 0.025 0.1498
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0141 0.0275
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0044 0.0184 0.0371
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0563 0.0546
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.0075 0.0057
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0526 0.4881 0.5452
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0033 0.0075 0.0191
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0238 0.022
Echinococcus multilocularis expressed protein 0.0036 0.0105 0.0087
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0764 0.0747
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0148 0.0191
Brugia malayi intermediate filament protein 0.0056 0.0307 0.0784
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.017 0.091
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1689 0.1674
Schistosoma mansoni hypothetical protein 0.1052 1 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0825 0.1184
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0033 0.0075 0.0153
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0304 0.0287
Leishmania major DNA polymerase eta, putative 0.0042 0.017 0.0818
Echinococcus multilocularis phd:f box containing protein 0.0051 0.025 0.0232
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0039 0.008
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0942 0.8937 1
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0825 0.0809
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0825 0.0905
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0056 0.0304 0.0286
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Trichomonas vaginalis rotamase, putative 0.0035 0.0097 0.0116
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0764 0.5261
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0359 0.0341
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0131 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0283 0.0724
Loa Loa (eye worm) hypothetical protein 0.0044 0.0181 0.0372
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0532 0.1363
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0131 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0694 0.0678
Trypanosoma cruzi ISWI complex protein 0.0031 0.0059 0.0295
Loa Loa (eye worm) hypothetical protein 0.0078 0.0515 0.1056
Echinococcus granulosus cpg binding protein 0.0035 0.0093 0.0075
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0357 0.2284
Loa Loa (eye worm) hypothetical protein 0.0044 0.0184 0.0376
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0033 0.0075 0.0153
Brugia malayi Bromodomain containing protein 0.0078 0.0514 0.1315
Plasmodium falciparum phd finger protein, putative 0.006 0.0336 1
Schistosoma mansoni d-amino acid oxidase 0.0526 0.4881 0.4871
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0053 0.0271 0.0253
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.1359 0.1343
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0053 0.0271 0.0371
Schistosoma mansoni lamin 0.0056 0.0307 0.0289
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0051 0.025 0.1665
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0148 0.013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0054 0.0283 0.0265
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0825 0.0809
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0178 0.1491 0.1475
Onchocerca volvulus 0.0068 0.0422 0.0904
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Brugia malayi phosphofructokinase 0.011 0.0825 0.2112
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.017 0.1411 0.2043
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0094 0.0076
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0562 0.0545
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0238 0.0487
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0357 0.034
Leishmania major DNA polymerase eta, putative 0.008 0.0532 0.3502
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0033 0.0075 0.0057
Schistosoma mansoni single-minded 0.0061 0.0355 0.0337
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.017 0.1411 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0825 0.1184
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0053 0.0271 0.1815
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0053 0.0271 0.0253
Echinococcus granulosus zinc finger protein 0.0041 0.016 0.0142
Loa Loa (eye worm) hypothetical protein 0.0117 0.0893 0.1829
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0053 0.0271 0.1815
Schistosoma mansoni alpha glucosidase 0.0036 0.0112 0.0094
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0044 0.0184 0.119
Echinococcus granulosus lamin dm0 0.0056 0.0307 0.0289
Schistosoma mansoni phd/f-box containing protein 0.0051 0.025 0.0232
Schistosoma mansoni alpha-glucosidase 0.0142 0.1135 0.112
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0044 0.0184 0.0166
Treponema pallidum fructose-bisphosphate aldolase 0.0727 0.6836 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0184 0.1194
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0094 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0105 0.0128
Plasmodium vivax SET domain protein, putative 0.0062 0.0357 1
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0044 0.0184 0.0186
Brugia malayi jmjC domain containing protein 0.0051 0.025 0.064
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.0075 0.0191
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.0075 0.0057
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0044 0.0184 0.0243
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0428 0.0602
Brugia malayi cDNA sequence BC016226 0.0044 0.0184 0.047
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0112 0.0138
Schistosoma mansoni intermediate filament proteins 0.0056 0.0307 0.0289
Brugia malayi Cation transporter family protein 0.0033 0.0075 0.0191
Brugia malayi 6-phosphofructokinase 0.011 0.0825 0.2112
Echinococcus granulosus lamin 0.0056 0.0307 0.0289
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0148 0.0379
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0238 0.022
Echinococcus granulosus nmda type glutamate receptor 0.0133 0.1052 0.1036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0307 0.0628
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0329 0.0312
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.0953 0.0937
Echinococcus granulosus single minded 2 0.0045 0.0199 0.0181
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0044 0.0184 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0348 0.2366
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0825 0.0809
Trypanosoma brucei ISWI complex protein 0.0031 0.0059 0.0295
Onchocerca volvulus 0.0485 0.448 1
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0544 0.059
Echinococcus granulosus intermediate filament protein 0.0056 0.0307 0.0289
Loa Loa (eye worm) hypothetical protein 0.0144 0.1155 0.2366
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0359 0.0341
Echinococcus granulosus nAChR subunit 0.0033 0.0075 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0148 0.013
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0044 0.0184 0.0166
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0544 0.3778
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0563 0.0546
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Schistosoma mansoni hypothetical protein 0.0413 0.3778 0.3767
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0044 0.0184 0.119
Plasmodium falciparum JmjC domain-containing protein, putative 0.0051 0.025 0.7028
Loa Loa (eye worm) hypothetical protein 0.006 0.0336 0.0689
Loa Loa (eye worm) ACC-1 protein 0.0033 0.0075 0.0153
Brugia malayi hypothetical protein 0.0068 0.0422 0.1079
Brugia malayi Muscleblind-like protein 0.0149 0.1204 0.3081
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0954 0.1954
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0044 0.0184 0.119
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.1013
Loa Loa (eye worm) hypothetical protein 0.017 0.1411 0.2891
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0044 0.0184 0.4754
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Echinococcus granulosus lysine specific demethylase 6a 0.0051 0.025 0.0232
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0131 0.0127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0075 0.0153
Schistosoma mansoni fad oxidoreductase 0.0044 0.0184 0.0166
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0044 0.0184 0.0186
Onchocerca volvulus 0.0029 0.0039 0.0047
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0442 0.0905
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0727 0.6836 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0694 0.0678
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.017 0.1089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0727 0.6836 1
Echinococcus multilocularis cpg binding protein 0.0035 0.0093 0.0075
Schistosoma mansoni nAChR subunit 0.0033 0.0075 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0045 0.004
Echinococcus multilocularis geminin 0.1052 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0054 0.0283 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0024
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0359 0.0918
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.3778 0.3767
Brugia malayi Pre-SET motif family protein 0.0062 0.0357 0.0914
Echinococcus multilocularis transfer RNA-Lys 0.0045 0.0199 0.0181
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0148 0.013
Trypanosoma brucei unspecified product 0.0037 0.0119 0.0728
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0359 0.0382
Onchocerca volvulus 0.0104 0.0771 0.1687
Echinococcus granulosus aryl hydrocarbon receptor 0.0133 0.1048 0.1032
Loa Loa (eye worm) hypothetical protein 0.0149 0.1204 0.2467
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0148 0.0191
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0148 0.013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.036 0.2306
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.0075 0.0057
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0359 0.2216
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0131 0.6188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0112 0.0138
Loa Loa (eye worm) hypothetical protein 0.0096 0.0694 0.1423
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0313 0.2804 0.2791
Echinococcus granulosus dnaJ subfamily B 0.0413 0.3778 0.3767
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0148 0.013
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0148 0.0191
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0054 0.0283 0.0579
Echinococcus granulosus jun protein 0.0087 0.0603 0.0586
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0218 0.0201
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Leishmania major DNA polymerase kappa, putative 0.0061 0.0348 0.2134
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1359 0.1343
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0033 0.0075 0.0191
Schistosoma mansoni bromodomain containing protein 0.013 0.1024 0.1008
Trichomonas vaginalis set domain proteins, putative 0.0485 0.448 0.6544
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0304 0.0287
Plasmodium vivax RNA helicase-1, putative 0.0053 0.0271 0.7226
Brugia malayi mbt repeat family protein 0.0049 0.0238 0.0608
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.0544 0.0772
Echinococcus multilocularis chromobox protein 1 0.007 0.0442 0.0424
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0053 0.0271 0.0371
Loa Loa (eye worm) ACC-1 protein 0.0033 0.0075 0.0153
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.0075 0.0191
Echinococcus multilocularis chromobox protein 1 0.007 0.0442 0.0424
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0336 0.2131
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.0075 0.0057
Brugia malayi PHD-finger family protein 0.0052 0.0265 0.0679
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.017 0.1411 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0304 0.0623
Brugia malayi excitatory GABA receptor EXP-1A 0.0033 0.0075 0.0191
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0544 0.3778
Echinococcus granulosus chromobox protein 1 0.007 0.0442 0.0424

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) = 557 uM Cytotoxic dose in MT-4 cells ChEMBL. 2754700
CD50 (functional) = 557 uM Cytotoxicity was determined as the dose required to reduce the viability of uninfected MT-4 cells by 50% ChEMBL. 3499515
CD50 (functional) > 625 uM Cytotoxicity was determined as the dose required to reduce the viability of uninfected MT-4 cells by 50% ChEMBL. 3499515
ED50 (functional) = 50 uM Inhibitory activity against HIV-1 replication in MT-4 cells ChEMBL. 2754700
ED50 (functional) = 50 uM Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction ChEMBL. 3499515
ED50 (functional) = 221 uM Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction ChEMBL. 3499515
Ratio (functional) > 2.8 Selectivity ratio of the compound CD50 to ED50 ChEMBL. 3499515
Ratio (functional) = 11.1 Selectivity ratio of the compound CD50 to ED50 ChEMBL. 3499515
SI (functional) = 11.1 Selectivity index is the ratio of ED50 and CD50 values against inhibition of HIV-1 in MT-4 cells ChEMBL. 2754700
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 125 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 5 uM concentration ChEMBL. 3497272
Toxicity (ADMET) < 10 % Toxicity was determined by evaluation of cluster morphology and reclustering properties in mock infected MT-4 cells at 0.2 uM concentration ChEMBL. 3497272

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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