Detailed information for compound 290662

Basic information

Technical information
  • TDR Targets ID: 290662
  • Name: 1-[2-cyano-5-(trifluoromethyl)phenyl]-1-[2-cy ano-5-(trifluoromethyl)phenyl]diazenyl-3-phen ylurea
  • MW: 502.371 | Formula: C23H12F6N6O
  • H donors: 1 H acceptors: 3 LogP: 5.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc(cc1N(C(=O)Nc1ccccc1)N=Nc1cc(ccc1C#N)C(F)(F)F)C(F)(F)F
  • InChi: 1S/C23H12F6N6O/c24-22(25,26)16-8-6-14(12-30)19(10-16)33-34-35(21(36)32-18-4-2-1-3-5-18)20-11-17(23(27,28)29)9-7-15(20)13-31/h1-11H,(H,32,36)
  • InChiKey: CXKRKFHHQMEKQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-cyano-5-(trifluoromethyl)phenyl]-1-[2-cyano-5-(trifluoromethyl)phenyl]azo-3-phenyl-urea
  • 1-[2-cyano-5-(trifluoromethyl)phenyl]-1-[2-cyano-5-(trifluoromethyl)phenyl]azo-3-phenylurea
  • 1-[2-cyano-5-(trifluoromethyl)phenyl]-1-[2-cyano-5-(trifluoromethyl)phenyl]diazenyl-3-phenyl-urea
  • 58458-18-7
  • 2-Triazene-1-carboxamide, 1,3-bis(2-cyano-5-(trifluoromethyl)phenyl)-N-phenyl-
  • SKF 63507

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0022 0.012
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.005 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0727 0.0847 0.752
Echinococcus granulosus tumor protein p63 0.0373 0.0427 0.0427
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1435 0.1688 1
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0235 0.2031
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0261 0.0293 0.0833
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Echinococcus granulosus MAM 0.0072 0.0068 0.0068
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0109 0.0957
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Brugia malayi hypothetical protein 0.0521 0.0602 0.5346
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.01 0.0582
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0126 0.1054
Echinococcus multilocularis MAM 0.0072 0.0068 0.0068
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0055 0.0048 0.0319
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0008 0.0008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0002 0.0009
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0009 0.0013
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0462 0.0532 0.3146
Schistosoma mansoni hypothetical protein 0.0186 0.0204 0.1197
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0163 0.1387
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0742 0.0865 0.2485
Echinococcus multilocularis musashi 0.003 0.0018 0.0018
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0057 0.005 0.0288
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0163 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.0823 0.7305
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0025 0.0025
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0126 0.0837
Giardia lamblia Kinase, CMGC GSK 0.0056 0.005 0.0332
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.04 0.0458 0.0458
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0008 0.0057
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0076 0.0074 0.334
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0008 0.0008
Echinococcus multilocularis protein kinase shaggy 0.0056 0.005 0.005
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0051 0.0043 0.0315
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0022 0.012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0727 0.0847 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0155 0.0168 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0687 0.0799 0.7088
Brugia malayi intermediate filament protein 0.003 0.0018 0.0145
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0088 0.0088 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0168 0.5865
Leishmania major cytochrome p450-like protein 0.0021 0.0009 0.0012
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0025 0.0208
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0002 0.0002
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0088 0.0717
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.0537 0.4737
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0155 0.0168 0.1431
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Entamoeba histolytica hypothetical protein 0.004 0.003 0.0198
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0126 0.0735
Schistosoma mansoni lamin 0.003 0.0018 0.0096
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.0273 0.2377
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0732 0.0853 0.7575
Giardia lamblia GTOR 0.0753 0.0877 1
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0031 0.0349
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0014
Onchocerca volvulus 0.0055 0.0048 0.1143
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1116
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0212 0.0235 0.0235
Entamoeba histolytica hypothetical protein 0.0155 0.0168 0.1431
Schistosoma mansoni fkbp-rapamycin associated protein 0.04 0.0458 0.2706
Echinococcus granulosus serine protein kinase ATM 0.0416 0.0477 0.0477
Brugia malayi follicle stimulating hormone receptor 0.0261 0.0293 0.2599
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0088 0.0088 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0488 0.0563 0.4972
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0477 0.4206
Echinococcus granulosus cyclin dependent kinase 19 0.0148 0.0159 0.0159
Toxoplasma gondii GAF domain-containing protein 0.0037 0.0027 0.0295
Loa Loa (eye worm) hypothetical protein 0.0442 0.0508 0.3384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0732 0.0853 0.7575
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0196 0.0216 0.2388
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0409 0.047 0.4136
Loa Loa (eye worm) hypothetical protein 0.0261 0.0293 0.1947
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.01 0.0582
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0409 0.047 0.5307
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0285 0.081
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0151 0.0163 0.1084
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.0126 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0022 0.012
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0008 0.0008
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.096 0.1124 1
Plasmodium falciparum casein kinase II beta chain 0.004 0.0031 0.0854
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Leishmania major phosphatidylinositol kinase, putative 0.0155 0.0168 0.0449
Entamoeba histolytica hypothetical protein 0.0804 0.0939 0.8343
Loa Loa (eye worm) intermediate filament protein 0.003 0.0018 0.0121
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.005 0.005
Brugia malayi M-phase phosphoprotein, mpp8 0.0111 0.0115 0.1008
Giardia lamblia Kinase, CMGC GSK 0.0056 0.005 0.0332
Loa Loa (eye worm) hypothetical protein 0.0528 0.061 0.4059
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0071 0.0566
Brugia malayi serine/threonine-protein kinase plk-2 0.0212 0.0235 0.2076
Echinococcus granulosus high voltage activated calcium channel beta 0.0096 0.0097 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0126 0.1054
Loa Loa (eye worm) hypothetical protein 0.0521 0.0602 0.4003
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0022 0.0237
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0027 0.0875
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0254 0.0285 0.0285
Echinococcus multilocularis tumor protein p63 0.0373 0.0427 0.0427
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.096 0.1124 1
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0126 0.1054
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0088 0.0088 0.0243
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0254 0.0285 0.2479
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Onchocerca volvulus 0.0155 0.0168 0.4116
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0022 0.0699
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0011 0.008
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0753 0.0877 0.2393
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0096 0.0097 0.0097
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0285 0.3349
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0002 0.0002
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0056 0.005 0.0126
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.008 0.008
Echinococcus granulosus lamin 0.003 0.0018 0.0018
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0287 0.0324 0.0324
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0008 0.0037
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1116
Echinococcus multilocularis casein kinase ii subunit alpha 0.0151 0.0163 0.0163
Leishmania major hypothetical protein, conserved 0.3089 0.3653 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0254 0.0285 0.0285
Brugia malayi hypothetical protein 0.0021 0.0008 0.0057
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.0823 0.7305
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0311 0.0353 0.3868
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0148 0.0159 0.1056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0141 0.015 0.0998
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0254 0.0285 0.0285
Schistosoma mansoni 6-phosphofructokinase 0.012 0.0126 0.0735
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.005 0.0374
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0168 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0056 0.005 0.1702
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.0126 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.1833
Trypanosoma cruzi casein kinase II, putative 0.0151 0.0163 0.0458
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0031 0.0725
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0287 0.0324 0.0324
Plasmodium vivax unspecified product 0.0151 0.0163 0.5692
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0008 0.0008
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0011 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0022 0.0022
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.0126 0.0837
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Echinococcus multilocularis serine protein kinase ATM 0.0416 0.0477 0.0477
Schistosoma mansoni hypothetical protein 0.0186 0.0204 0.1197
Brugia malayi intracellular kinase 0.0056 0.005 0.0429
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0018 0.0145
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0442 0.0508 0.5995
Plasmodium falciparum casein kinase 2, alpha subunit 0.0151 0.0163 0.5605
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0053 0.0046 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.0273 0.2377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.0823 0.7305
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0117
Leishmania major phosphatidylinositol 3-kinase, putative 0.0687 0.0799 0.2178
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0212 0.0235 0.0235
Entamoeba histolytica serine/threonine protein kinase, putative 0.0212 0.0235 0.2031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0732 0.0853 0.7575
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0013
Schistosoma mansoni hypothetical protein 0.0155 0.0168 0.0984
Giardia lamblia Kinase, CMGC CK2 0.0151 0.0163 0.1651
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.005 0.0374
Echinococcus granulosus bloom syndrome protein 0.0023 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0687 0.0799 0.7088
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0235 0.2031
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.0168 0.1431
Trypanosoma cruzi target of rapamycin kinase 3 0.0732 0.0853 0.2451
Onchocerca volvulus 0.026 0.0292 0.719
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0022 0.0699
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0698 0.0813 0.0813
Schistosoma mansoni serine/threonine protein kinase 0.0355 0.0405 0.2391
Entamoeba histolytica protein kinase rad3, putative 0.04 0.0458 0.4034
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0254 0.0285 0.1678
Onchocerca volvulus 0.0106 0.0109 0.2662
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.0285 0.1896
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0753 0.0877 0.5193
Leishmania major hypothetical protein, conserved 0.004 0.003 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0163 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0712 0.0829 0.7359
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0031 0.0078
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0013 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.2933 0.3469 1
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0096 0.0097 0.0564
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0088 0.0088 0.0088
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.005 0.005
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.5865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0727 0.0847 0.752
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0008 0.0055
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0031 0.0078
Onchocerca volvulus 0.003 0.0018 0.0403
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0155 0.0168 0.1833
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0727 0.0847 0.752
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0013 0.0084
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.01 0.01
Echinococcus multilocularis geminin 0.0186 0.0204 0.0204
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0051 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0071 0.0566
Brugia malayi Cytochrome P450 family protein 0.0021 0.0009 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.04 0.0458 0.4068
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.04 0.0458 0.1311
Leishmania major hypothetical protein, unknown function 0.0155 0.0168 0.0449
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0056 0.005 0.0132
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0355 0.0405 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0409 0.047 0.4136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0727 0.0847 0.752
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0025 0.0138
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0727 0.0847 0.752
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0121
Schistosoma mansoni intermediate filament proteins 0.003 0.0018 0.0096
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0008 0.0037
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0753 0.0877 0.2393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.0823 0.7305
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0031 0.0261
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0235 0.2031
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.002 0.002
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0168 0.0472
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0168 0.1966
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0355 0.0405 0.0405
Brugia malayi Protein kinase domain containing protein 0.0602 0.0699 0.6212
Echinococcus granulosus survival motor neuron protein 1 0.0521 0.0602 0.0602
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0355 0.0405 0.3593
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0027 0.0177
Loa Loa (eye worm) phosphatidylinositol 3 0.0753 0.0877 0.5838
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0096 0.0097 0.0097
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.0235 0.0666
Toxoplasma gondii CMGC kinase, CK2 family 0.0151 0.0163 0.1908
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0022 0.5
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0008 0.0008
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0051 0.0043 0.0043
Echinococcus granulosus lamin dm0 0.003 0.0018 0.0018
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.096 0.1124 0.3231
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Brugia malayi Serotonin receptor 0.0515 0.0596 0.5292
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0126 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.0823 0.7304
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0163 0.1387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0022 0.0119
Loa Loa (eye worm) phosphatidylinositol 3 0.0698 0.0813 0.5409
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0416 0.0477 0.282
Plasmodium falciparum GAF domain-related protein, putative 0.0037 0.0027 0.069
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0254 0.0285 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0176 0.0192 0.1646
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0235 0.2031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.0877 0.7791
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0753 0.0877 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0047 0.0348
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Loa Loa (eye worm) hypothetical protein 0.0287 0.0324 0.2154
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.0405 0.2694
Entamoeba histolytica hypothetical protein 0.004 0.003 0.0198
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0753 0.0877 0.7791
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.0285 0.2479
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0011 0.0023
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Onchocerca volvulus 0.0155 0.0168 0.4116
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0235 0.2031
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0753 0.0877 0.252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0022 0.0119
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0254 0.0285 0.2522
Schistosoma mansoni hypothetical protein 0.0072 0.0068 0.0394
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0168 0.1479
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.008 0.008
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0031 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.0823 0.7304
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0013 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0168 0.1966
Leishmania major ATP-dependent phosphofructokinase 0.012 0.0126 0.0334
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0155 0.0168 0.0984
Trypanosoma brucei polo-like protein kinase 0.0212 0.0235 0.2605
Brugia malayi hypothetical protein 0.004 0.003 0.0253
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0198 0.0218 0.1449
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0009 0.0057
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0128 0.0135 0.1139
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0022 0.0147
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0018 0.0121
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0155 0.0168 0.5781
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0008 0.0055
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0052 0.0045 0.0117
Echinococcus multilocularis expressed protein 0.0413 0.0473 0.0473
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0088 0.0717
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.001 0.0067
Loa Loa (eye worm) phosphofructokinase 0.012 0.0126 0.0837
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0071 0.0566
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0088 0.0088 0.0717
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0475 0.0547 0.486
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0035
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0206
Brugia malayi Pre-SET motif family protein 0.0033 0.0022 0.0179
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0022 0.5
Schistosoma mansoni single-minded 0.0054 0.0047 0.0267
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.0285 0.2479
Echinococcus multilocularis survival motor neuron protein 1 0.0521 0.0602 0.0602
Brugia malayi Protein kinase domain containing protein 0.0355 0.0405 0.3593
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0009 0.0057
Schistosoma mansoni kinase 0.0109 0.0113 0.0658
Echinococcus granulosus 6 phosphofructokinase 0.012 0.0126 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0687 0.0799 0.7088
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0409 0.047 0.4136
Schistosoma mansoni lamin 0.003 0.0018 0.0096
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.5865
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0409 0.047 0.4136
Brugia malayi hypoxia-induced factor 1 0.0166 0.0181 0.1595
Schistosoma mansoni transcription factor LCR-F1 0.004 0.003 0.0168
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0254 0.0285 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.005 0.0374
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0126 0.1054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0753 0.0877 0.252
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0013 0.0013
Echinococcus granulosus Ankyrin 0.0016 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.0228 0.0254 0.2248
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0126 0.0351
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.0293 0.1953
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0002 0.0012
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0254 0.0285 0.1678
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.0126 0.7026
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0416 0.0477 0.1366
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0025 0.0025
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0031 0.0173
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0355 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0072 0.0068 0.0455
Echinococcus granulosus expressed conserved protein 0.009 0.009 0.009
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0312 0.0354 0.2353
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0008 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0804 0.0939 0.8343
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0753 0.0877 1
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.0324 0.2829
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0212 0.0235 0.0632
Brugia malayi Uncoordinated protein 44 0.0016 0.0002 0.0001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0698 0.0813 0.2216
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0753 0.0877 0.0877
Trichomonas vaginalis conserved hypothetical protein 0.0442 0.0508 0.4485
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0742 0.0865 0.2485
Loa Loa (eye worm) RecQ helicase 0.0023 0.0011 0.0072
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0168 0.1966
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.0506 0.4466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.0813 0.7214
Echinococcus granulosus expressed protein 0.0413 0.0473 0.0473
Giardia lamblia Phosphatidylinositol 4-kinase 0.0155 0.0168 0.1708
Leishmania major casein kinase II, putative 0.0151 0.0163 0.0435
Onchocerca volvulus 0.004 0.003 0.0705
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0159 0.093
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.0126 0.7026
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0002 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0163 0.1387
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0151 0.0163 0.5692
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0698 0.0813 0.9259
Brugia malayi Cytochrome P450 family protein 0.0033 0.0022 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0712 0.0829 0.7359
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.0472
Brugia malayi hypothetical protein 0.0072 0.0068 0.0593
Loa Loa (eye worm) hypothetical protein 0.018 0.0197 0.1313
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0409 0.047 0.417
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0254 0.0285 0.2479
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0168 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0155 0.0168 0.0984
Entamoeba histolytica hypothetical protein 0.004 0.003 0.0198
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.0472
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0008 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0701 0.0816 0.7255
Entamoeba histolytica hypothetical protein 0.004 0.003 0.0198
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0025 0.0138
Brugia malayi phosphofructokinase 0.012 0.0126 0.1105
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0163 0.1387
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0285 0.0769
Echinococcus multilocularis cyclin dependent kinase 19 0.0148 0.0159 0.0159
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0088 0.0088 0.0717
Echinococcus multilocularis lamin 0.003 0.0018 0.0018
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0687 0.0799 0.9097
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1435 0.1688 0.1688
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0088 0.0088 0.0717
Onchocerca volvulus 0.003 0.0018 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0687 0.0799 0.7088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0727 0.0847 0.752
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.0506 0.4466
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0566 0.0655 0.7407
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0212 0.0235 0.1562
Entamoeba histolytica hypothetical protein 0.0155 0.0168 0.1431
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0128 0.0135 0.1139
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0896 0.1048 0.1048
Loa Loa (eye worm) hypothetical protein 0.0111 0.0115 0.0766
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0031 0.0725
Leishmania major phosphatidylinositol 3-kinase, putative 0.0254 0.0285 0.0769
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0056 0.005 0.0572
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0155 0.0168 0.0984
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0463 0.0533 0.6033
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0742 0.0865 0.5119
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Schistosoma mansoni hypothetical protein 0.0106 0.0109 0.0636
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0022 0.024
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0022 0.012
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0285 0.318
Loa Loa (eye worm) hypothetical protein 0.0155 0.0168 0.1116
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0742 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.04 0.0458 0.3049
Toxoplasma gondii hypothetical protein 0.0037 0.0027 0.0295
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0416 0.0477 0.5397
Echinococcus multilocularis 0.0155 0.0168 0.0168
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0051 0.0043 0.037
Mycobacterium ulcerans putative regulatory protein 0.004 0.003 0.1861
Plasmodium vivax hypothetical protein 0.0155 0.0168 0.5865
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.003 0.0255
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.096 0.1124 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.01 0.01
Loa Loa (eye worm) hypoxia-induced factor 1 0.0166 0.0181 0.1203
Toxoplasma gondii hypothetical protein 0.0037 0.0027 0.0295
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0043 0.0315
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.0126 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0235 0.2031
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0168 0.1431
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0022 0.0237
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0027 0.1543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.0877 0.7791
Plasmodium falciparum glycogen synthase kinase 3 0.0056 0.005 0.1534
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0727 0.0847 0.752
Brugia malayi SH2 domain containing protein 0.0376 0.043 0.3812
Loa Loa (eye worm) Csnk2b protein 0.004 0.0031 0.0207
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0732 0.0853 0.9723
Echinococcus granulosus death domain containing protein 0.0016 0.0002 0.0002
Plasmodium vivax SET domain protein, putative 0.0033 0.0022 0.071
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0742 0.0865 0.0865
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0022 0.012
Brugia malayi 6-phosphofructokinase 0.012 0.0126 0.1105
Entamoeba histolytica phosphofructokinase, putative 0.012 0.0126 0.1054
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0155 0.0168 0.0168
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0206
Onchocerca volvulus 0.0072 0.0068 0.1649
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0031 0.0031
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.046 0.0529 0.4671
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.011 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0027 0.0165
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0698 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0054 0.0047 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.0458 0.4034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0002 0.0013
Schistosoma mansoni hypothetical protein 0.004 0.003 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0732 0.0853 0.7575
Loa Loa (eye worm) phosphatidylinositol kinase 0.0155 0.0168 0.1116
Onchocerca volvulus 0.0111 0.0115 0.2804
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0088 0.0088 0.0917
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0031 0.1036
Echinococcus granulosus protein kinase shaggy 0.0056 0.005 0.005
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0008 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0446 0.0512 0.4521
Loa Loa (eye worm) hypothetical protein 0.0376 0.043 0.2858
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0707 0.0823 0.7304
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.096 0.1124 1
Brugia malayi bHLH-PAS transcription factor 0.004 0.003 0.0254
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0008 0.0008
Leishmania major phosphatidylinositol kinase related protein, putative 0.0172 0.0187 0.0501
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.0126 0.135
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0047 0.0267
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0022 0.051
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0076 0.0074 0.5563
Entamoeba histolytica protein kinase domain containing protein 0.0151 0.0163 0.1387
Onchocerca volvulus Serine\/threonine kinase homolog 0.0212 0.0235 0.5778
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0055
Echinococcus multilocularis high voltage activated calcium channel beta 0.0096 0.0097 0.0097
Leishmania major phosphatidylinositol 4-kinase, putative 0.0155 0.0168 0.0449
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0008 0.0037
Trypanosoma brucei Casein kinase II 0.0151 0.0163 0.1777
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0254 0.0285 0.1895
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.096 0.1124 1
Echinococcus multilocularis transfer RNA-Lys 0.004 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0111 0.0115 0.0765
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Onchocerca volvulus 0.0072 0.0068 0.1649
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0022 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0135 0.1139
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.004 0.003 0.025
Toxoplasma gondii hypothetical protein 0.0074 0.0071 0.0825
Brugia malayi Protein kinase domain containing protein 0.002 0.0006 0.004
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0753 0.0877 0.0877
Giardia lamblia Casein kinase II beta chain 0.004 0.0031 0.0112
Loa Loa (eye worm) hypothetical protein 0.0072 0.0068 0.0455
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.0405 0.2694
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0168 0.1116
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0412 0.0472 0.416
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0008 0.0008
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0031 0.1036
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0008 0.0057
Echinococcus multilocularis Ankyrin 0.0016 0.0002 0.0002
Schistosoma mansoni protein kinase 0.0151 0.0163 0.0955
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0721 0.084 0.7459
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0025 0.0025
Echinococcus granulosus serine:threonine protein kinase SMG1 0.04 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0033 0.0022 0.0146
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.0285 0.3349
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1435 0.1688 0.1688
Onchocerca volvulus 0.0056 0.005 0.1193
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0009 0.0013
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0051 0.0043 0.0315
Echinococcus granulosus geminin 0.0186 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0287 0.0324 0.1909
Entamoeba histolytica hypothetical protein 0.0155 0.0168 0.1431
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0022 0.0022
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0008 0.0057
Brugia malayi Protein kinase domain containing protein 0.0148 0.0159 0.1399
Brugia malayi 6-phosphofructokinase 0.012 0.0126 0.1105
Plasmodium falciparum casein kinase II beta chain 0.004 0.0031 0.0854
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0008 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0212 0.0235 0.2031
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0088 0.0088 0.0917
Brugia malayi FAT domain containing protein 0.0287 0.0324 0.2869
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0168 0.5781
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.005 0.0333
Schistosoma mansoni hypothetical protein 0.0072 0.0068 0.0394
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.003 0.003
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0052 0.0045 0.0326
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0409 0.047 0.1344
Loa Loa (eye worm) phosphatidylinositol 3 0.1279 0.1503 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0742 0.0865 0.7693
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0002 0.0009
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0005 0.0018
Trypanosoma brucei protein kinase, putative 0.0056 0.005 0.0478
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0088 0.0717
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0804 0.0939 0.8344
Brugia malayi PXA domain containing protein 0.0023 0.001 0.0073
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.004 0.003 0.0075
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0002 0.000000029032
Loa Loa (eye worm) gastrulation defective protein 1 0.0144 0.0154 0.1027
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0009 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0412 0.0472 0.416
Loa Loa (eye worm) calcium channel 0.0035 0.0025 0.0167
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0168 0.1479
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0141 0.015 0.0878
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.843 1 1
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0198 0.0218 0.1925
Entamoeba histolytica protein kinase, putative 0.0056 0.005 0.0374
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0168 0.5865
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0013 0.0096
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0151 0.0163 0.1387
Loa Loa (eye worm) hypothetical protein 0.0072 0.0068 0.0455
Trichomonas vaginalis set domain proteins, putative 0.026 0.0292 0.254
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Echinococcus granulosus intermediate filament protein 0.003 0.0018 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0022 0.012
Entamoeba histolytica hypothetical protein 0.0416 0.0477 0.4206
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0022 0.012
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0254 0.0285 0.0285
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0753 0.0877 0.7804
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0254 0.0285 0.081
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Brugia malayi hypothetical protein 0.0111 0.0115 0.1009
Brugia malayi hypothetical protein 0.018 0.0197 0.1743
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0141 0.015 0.1321
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0048 0.0273
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0027 0.1543
Echinococcus multilocularis expressed conserved protein 0.009 0.009 0.009
Giardia lamblia Hypothetical protein 0.0155 0.0168 0.1708
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.011 0.0908
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0022 0.0237
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0088 0.0088 0.0243
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.0235 0.1381
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0031 0.0031
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.0285 0.081
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0492 0.0568 0.502
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.009 0.009 0.0523
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0002 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0022 0.0022
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0206
Echinococcus granulosus single minded 2 0.004 0.003 0.003
Giardia lamblia Kinase, PLK 0.0212 0.0235 0.2491
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0037 0.0207
Toxoplasma gondii ck2 beta subunit 0.004 0.0031 0.0349
Schistosoma mansoni survival motor neuron protein 0.0106 0.0109 0.0636
Trypanosoma cruzi polo-like protein kinase, putative 0.0212 0.0235 0.0666
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0025 0.0025
Brugia malayi Casein kinase II, alpha chain 0.0151 0.0163 0.1436
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0022 0.012
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0753 0.0877 0.7791
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0025 0.0138
Brugia malayi Death domain containing protein 0.0016 0.0002 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.096 0.1124 0.3231
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Brugia malayi PAS domain containing protein 0.0054 0.0047 0.0402
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0416 0.0477 0.4239
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0168 0.0168
Toxoplasma gondii FATC domain-containing protein 0.0416 0.0477 0.5627
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0008 0.0008
Brugia malayi hypothetical protein 0.0021 0.0008 0.0057
Brugia malayi Csnk2b protein 0.004 0.0031 0.0261
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0254 0.0285 0.2479
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0022 0.051
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0088 0.0088 0.0511
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0168 0.1479
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0008 0.0008
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0698 0.0813 0.5407
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.005 0.0285
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0168 0.1431
Entamoeba histolytica casein kinase, putative 0.0151 0.0163 0.1387
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.004 0.003 0.0075
Echinococcus granulosus casein kinase ii subunit alpha 0.0151 0.0163 0.0163
Onchocerca volvulus 0.0045 0.0037 0.0865
Brugia malayi Cytochrome P450 family protein 0.0021 0.0009 0.0059
Onchocerca volvulus 0.0111 0.0115 0.2804
Brugia malayi PXA domain containing protein 0.0023 0.001 0.0073
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0155 0.0168 0.1431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0753 0.0877 0.7791
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.0506 0.4466
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.005 0.0374
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0052 0.0045 0.0326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0088 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0732 0.0853 0.7575
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0172 0.0187 0.0528
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0732 0.0853 0.2327
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0128 0.0135 0.1139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.0254 0.1691
Echinococcus multilocularis lamin dm0 0.003 0.0018 0.0018
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.0126 0.0126
Loa Loa (eye worm) TK/ALK protein kinase 0.0602 0.0698 0.4648
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0721 0.084 0.7459

Activities

Activity type Activity value Assay description Source Reference
Body weight reduction (functional) = 46 % Percentage of body weight reduction in male Sprague-Dawley rats at 50 mg/kg; 46-60% reduction from controls ChEMBL. 6854589
Reduction (functional) = 0 Reduction in food consumption in male Sprague-Dawley rats at 50 mg/kg; 2= Significant reduction at 3 or 4 intervals ChEMBL. 6854589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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