Detailed information for compound 290901

Basic information

Technical information
  • TDR Targets ID: 290901
  • Name: S-[2-[[4-(4-nitrophenyl)sulfonylphenyl]carbam oyl]phenyl] 5-bromopentanethioate
  • MW: 577.467 | Formula: C24H21BrN2O6S2
  • H donors: 1 H acceptors: 6 LogP: 5.08 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: BrCCCCC(=O)Sc1ccccc1C(=O)Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C24H21BrN2O6S2/c25-16-4-3-7-23(28)34-22-6-2-1-5-21(22)24(29)26-17-8-12-19(13-9-17)35(32,33)20-14-10-18(11-15-20)27(30)31/h1-2,5-6,8-15H,3-4,7,16H2,(H,26,29)
  • InChiKey: CPDKMBCYZTXOAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-bromopentanethioic acid S-[2-[[4-(4-nitrophenyl)sulfonylanilino]-oxomethyl]phenyl] ester
  • 5-bromopentanethioic acid S-[2-[(4-nosylphenyl)carbamoyl]phenyl] ester
  • 5-bromopentanethioic acid S-[2-[[[4-(4-nitrophenyl)sulfonylphenyl]amino]-oxomethyl]phenyl] ester
  • 5-bromopentanethioic acid S-[2-[[4-(4-nitrophenyl)sulfonylphenyl]carbamoyl]phenyl] ester
  • [2-(5-Bromopentanoylthio)phenyl]-N-{4-[(4-nitrophenyl)sulfonyl]phenyl}carboxamide
  • AIDS-071883
  • AIDS071883

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Brugia malayi phosphofructokinase 0.0115 0.0143 0.1107
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0124 0.0959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0341 0.0467 0.3606
Brugia malayi Serotonin receptor 0.0495 0.0686 0.5303
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0357 0.0489 0.2491
Schistosoma mansoni protein kinase 0.0145 0.0186 0.0948
Toxoplasma gondii FATC domain-containing protein 0.0357 0.0489 0.5625
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.001 0.008
Loa Loa (eye worm) gastrulation defective protein 1 0.0138 0.0176 0.101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.0813 0.6262
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0008 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.0269 0.1372
Loa Loa (eye worm) hypothetical protein 0.0663 0.0928 0.532
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.005 0.0049 0.0135
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0143 0.073
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0231 0.0309 1
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0033 0.1861
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0143 0.0407
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0135 0.0171 0.0873
Brugia malayi hypothetical protein 0.002 0.0007 0.0057
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0012 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Brugia malayi Cytochrome P450 family protein 0.0031 0.0023 0.018
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0143 0.0143
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0054 0.0056 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0557 0.4275
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.0099 0.0712
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Onchocerca volvulus 0.0107 0.0131 0.2805
Echinococcus multilocularis bloom syndrome protein 0.0022 0.001 0.001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0084 0.0099 0.0712
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0039 0.0034 0.0086
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0357 0.0489 0.537
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0023 0.012
Schistosoma mansoni lamin 0.0028 0.0019 0.0096
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0048 0.0047 0.031
Schistosoma mansoni casein kinase II beta subunit 0.0039 0.0034 0.0172
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0231 0.0309 0.0308
Plasmodium vivax SET domain protein, putative 0.0031 0.0023 0.0013
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0007 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0646 0.0904 0.2468
Echinococcus multilocularis Zinc finger, PHD finger 0.0231 0.0309 0.0308
Loa Loa (eye worm) hypothetical protein 0.0304 0.0413 0.2368
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0031 0.0232
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0242 0.0325 0.0325
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0084 0.0099 0.0279
Brugia malayi Pre-SET motif family protein 0.0219 0.0292 0.2254
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0023 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.0904 0.6967
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.5202
Entamoeba histolytica serine/threonine protein kinase, putative 0.0203 0.0269 0.2035
Brugia malayi Cytochrome P450 family protein 0.0021 0.0008 0.0059
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0841 0.6479
Toxoplasma gondii hypothetical protein 0.0071 0.008 0.0914
Onchocerca volvulus 0.0054 0.0056 0.1193
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0186 0.139
Echinococcus multilocularis geminin 0.0178 0.0233 0.0233
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0143 0.0821
Echinococcus granulosus single minded 2 0.0038 0.0033 0.0033
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0203 0.0269 0.1543
Leishmania major hypothetical protein, unknown function 0.0135 0.0171 0.0462
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0135 0.0171 0.0171
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0919 0.1294 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0039 0.0034 0.0034
Brugia malayi PXA domain containing protein 0.0022 0.0009 0.0073
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0377 0.0518 0.2968
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0274 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0841 0.6479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0841 0.6478
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.0488
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0143 0.1056
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0023 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0023 0.0118
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0433 0.0598 0.3049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0646 0.0904 0.6984
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0269 0.2035
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0646 0.0904 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.015 0.0194 0.0523
Onchocerca volvulus 0.0043 0.004 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.0467 0.357
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0186 0.139
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.5202
Echinococcus granulosus intermediate filament protein 0.0028 0.0019 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0269 0.2035
Loa Loa (eye worm) hypothetical protein 0.0499 0.0693 0.3974
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0534 0.0743 0.8179
Echinococcus multilocularis expressed conserved protein 0.0086 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0022
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0034 0.0027 0.0027
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0686 0.0961 0.741
Brugia malayi follicle stimulating hormone receptor 0.0251 0.0337 0.2605
Schistosoma mansoni hypothetical protein 0.0135 0.0171 0.0873
Schistosoma mansoni intermediate filament proteins 0.0028 0.0019 0.0096
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0269 0.2035
Brugia malayi Protein kinase domain containing protein 0.0341 0.0466 0.36
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.008 0.0563
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0007 0.0057
Loa Loa (eye worm) Csnk2b protein 0.0039 0.0034 0.0194
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0341 0.0466 0.0466
Brugia malayi hypoxia-induced factor 1 0.016 0.0207 0.1598
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0023 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.0876 0.675
Echinococcus granulosus high voltage activated calcium channel beta 0.0092 0.011 0.011
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0008 0.0044
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.0488
Schistosoma mansoni hypothetical protein 0.0054 0.0056 0.0286
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0007 0.0007
Trypanosoma cruzi target of rapamycin kinase 3 0.0627 0.0876 0.2525
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0023 0.0118
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0287 0.0389 0.4154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.0876 0.675
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0357 0.0489 0.3778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0608 0.0848 0.6534
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.0031 0.0083
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0063
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0028 0.1504
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0012 0.0012
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0007 0.0007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0646 0.0904 0.2468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0869 0.6695
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0028 0.0183
Entamoeba histolytica hypothetical protein 0.0135 0.0171 0.1275
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0309 0.3357
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0646 0.0904 0.0904
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0034 0.0027 0.0137
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0034 0.0386
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0054 0.0056 0.0153
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Trypanosoma cruzi hypothetical protein, conserved 0.2433 0.3463 1
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0092 0.011 0.056
Leishmania major cytochrome p450-like protein 0.0021 0.0008 0.0014
Loa Loa (eye worm) phosphatidylinositol 3 0.0135 0.0171 0.0983
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0009 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0869 0.6695
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0135 0.0171 0.1275
Loa Loa (eye worm) phosphatidylinositol kinase 0.0135 0.0171 0.0983
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0627 0.0876 0.969
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0135 0.0171 0.1969
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.005 0.0049 0.0325
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0007 0.0007
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0636 0.089 0.089
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0135 0.0171 0.0488
Leishmania major phosphatidylinositol 3-kinase, putative 0.0583 0.0813 0.2219
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.0269 0.0771
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0095 0.0114 0.0114
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0341 0.0467 0.0467
Schistosoma mansoni serine/threonine protein kinase 0.0341 0.0466 0.2374
Leishmania major phosphatidylinositol 3-kinase, putative 0.0231 0.0309 0.0838
Schistosoma mansoni lamin 0.0028 0.0019 0.0096
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0231 0.0309 0.234
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0595 0.083 0.917
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0143 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0023 0.0262
Loa Loa (eye worm) phosphatidylinositol 3 0.0248 0.0333 0.1907
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0135 0.0171 0.1969
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0000070835 0.0001
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0034 0.0206
Onchocerca volvulus 0.0052 0.0053 0.1143
Toxoplasma gondii ck2 beta subunit 0.0039 0.0034 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.038 0.0523 0.4003
Brugia malayi hypothetical protein 0.0173 0.0226 0.1746
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.009 0.009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0383 0.0526 0.5783
Loa Loa (eye worm) phosphatidylinositol 3 0.0135 0.0171 0.0983
Onchocerca volvulus 0.0028 0.0019 0.0403
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0203 0.0269 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.0813 0.6262
Brugia malayi serine/threonine-protein kinase plk-2 0.0203 0.0269 0.2081
Echinococcus granulosus bloom syndrome protein 0.0022 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0274 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0608 0.0848 0.6534
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0034 0.009
Leishmania major hypothetical protein, conserved 0.2568 0.3656 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0135 0.0171 0.0171
Brugia malayi FAT domain containing protein 0.0242 0.0325 0.2509
Loa Loa (eye worm) phosphatidylinositol 3 0.0135 0.0171 0.0983
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0007 0.0042
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0072 0.0081 0.3706
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0028 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0869 0.6695
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0335 0.2546
Brugia malayi hypothetical protein 0.002 0.0007 0.0057
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0231 0.0309 0.2384
Leishmania major casein kinase II, putative 0.0145 0.0186 0.0503
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0143 0.1056
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0309 0.0884
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0051 0.0336
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0121 0.0152 0.1125
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0132 0.0167 0.0853
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Brugia malayi Protein kinase domain containing protein 0.0142 0.0181 0.1401
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0135 0.0171 0.5462
Brugia malayi M-phase phosphoprotein, mpp8 0.0107 0.0131 0.101
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0056 0.0319
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0154
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0231 0.0309 0.1572
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0341 0.0466 0.0466
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0919 0.1294 0.3733
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0143 0.0821
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0467 0.0646 0.4995
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0019 0.0108
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0143 0.0821
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0231 0.0309 0.0308
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.0031 0.0083
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0686 0.0961 0.741
Onchocerca volvulus 0.0028 0.0019 0.0403
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0008 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0186 0.139
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0051 0.0051 0.0291
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0039 0.0034 0.0385
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0231 0.0309 0.234
Echinococcus multilocularis high voltage activated calcium channel beta 0.0092 0.011 0.011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0135 0.0171 0.1969
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0231 0.0309 0.1768
Echinococcus granulosus serine protein kinase ATM 0.0357 0.0489 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0242 0.0325 0.2466
Entamoeba histolytica hypothetical protein 0.0357 0.0489 0.3743
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0114 0.0579
Toxoplasma gondii GAF domain-containing protein 0.0035 0.0028 0.0318
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0919 0.1294 1
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0143 0.0143
Echinococcus multilocularis lamin 0.0028 0.0019 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0124 0.091
Entamoeba histolytica protein kinase, putative 0.0054 0.0056 0.0375
Echinococcus multilocularis lamin dm0 0.0028 0.0019 0.0019
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.0049 0.0325
Brugia malayi hypothetical protein 0.0499 0.0693 0.5358
Entamoeba histolytica casein kinase, putative 0.0145 0.0186 0.139
Entamoeba histolytica hypothetical protein 0.0767 0.1077 0.8311
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0007 0.0007
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.019 0.025 0.1431
Schistosoma mansoni hypothetical protein 0.0086 0.0102 0.052
Trypanosoma brucei protein kinase, putative 0.0054 0.0056 0.0535
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0646 0.0904 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0636 0.089 0.6874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0353 0.0483 0.3696
Trichomonas vaginalis PIKK family atypical protein kinase 0.038 0.0523 0.4003
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0048 0.0047 0.0047
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0135 0.0171 0.0488
Giardia lamblia Kinase, PLK 0.0203 0.0269 0.2797
Plasmodium falciparum casein kinase 2, alpha subunit 0.0145 0.0186 0.5949
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0033 0.0254
Echinococcus multilocularis 0.0135 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0377 0.0518 0.3968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.0581 0.4456
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0242 0.0325 0.0325
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0084 0.0099 0.0504
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0636 0.089 0.2564
Schistosoma mansoni hypothetical protein 0.0178 0.0233 0.1189
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0383 0.0526 0.403
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0034 0.0027 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0171 0.1275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.0813 0.6262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.0876 0.675
Brugia malayi intermediate filament protein 0.0028 0.0019 0.0146
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.0099 0.0712
Loa Loa (eye worm) RGS-3 protein 0.002 0.0007 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0135 0.0171 0.5202
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0063
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0007 0.0007
Echinococcus granulosus expressed protein 0.0396 0.0545 0.0545
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.009 0.009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0023 0.0023
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0037 0.0031 0.0265
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0203 0.0269 0.0269
Brugia malayi 6-phosphofructokinase 0.0115 0.0143 0.1107
Loa Loa (eye worm) RecQ helicase 0.0022 0.001 0.0059
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0034 0.0725
Brugia malayi Casein kinase II, alpha chain 0.0145 0.0186 0.1438
Brugia malayi Uncoordinated protein 44 0.0015 0.0000070892 0.0001
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0174 0.0227 0.2449
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0135 0.0171 0.0873
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0396 0.0546 0.6005
Brugia malayi 6-phosphofructokinase 0.0115 0.0143 0.1107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0841 0.6478
Onchocerca volvulus 0.0135 0.0171 0.3679
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0023 0.0118
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0012 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.0904 0.6967
Brugia malayi intracellular kinase 0.0054 0.0056 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.008 0.0563
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Loa Loa (eye worm) hypothetical protein 0.0052 0.0053 0.0306
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0341 0.0466 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0007 0.0007
Brugia malayi Csnk2b protein 0.0039 0.0034 0.0262
Leishmania major hypothetical protein, conserved 0.0037 0.0031 0.0079
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0000070892 0.000000028841
Schistosoma mansoni single-minded 0.0052 0.0052 0.0265
Plasmodium vivax glycogen synthase kinase 3, putative 0.0054 0.0056 0.1148
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0023 0.012
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0007 0.0007
Echinococcus multilocularis protein kinase shaggy 0.0054 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0007 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0269 0.2035
Loa Loa (eye worm) hypothetical protein 0.0242 0.0325 0.1861
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1386 0.1963 0.1962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0869 0.6695
Loa Loa (eye worm) hypothetical protein 0.0341 0.0467 0.2675
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0092 0.011 0.011
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0463 0.0642 0.4931
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0000070892 0.0000000056599
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0133
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0095 0.0114 0.0114
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0007 0.0007
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0048 0.0047 0.0047
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0056 0.0375
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0007 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0143 0.1056
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.001 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0383 0.0526 0.403
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0646 0.0904 0.6967
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0053 0.0271
Giardia lamblia Kinase, CMGC CK2 0.0145 0.0186 0.1854
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0121 0.0152 0.1125
Onchocerca volvulus Serine\/threonine kinase homolog 0.0203 0.0269 0.5778
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0636 0.089 0.2564
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0636 0.089 0.4533
Echinococcus granulosus survival motor neuron protein 1 0.0499 0.0693 0.0693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0869 0.6695
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0012 0.0096
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0143 0.073
Echinococcus multilocularis musashi 0.0028 0.0019 0.0019
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0231 0.0309 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0007 0.0057
Entamoeba histolytica hypothetical protein 0.0038 0.0033 0.0198
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0841 0.6479
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0056 0.0375
Brugia malayi Protein kinase domain containing protein 0.0019 0.0005 0.004
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0084 0.0099 0.0712
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0186 0.139
Brugia malayi hypothetical protein 0.0107 0.0131 0.1012
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0039 0.0034 0.0292
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0007 0.0007
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0135 0.0171 0.1275
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0007 0.0057
Plasmodium vivax unspecified product 0.0145 0.0186 0.5717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0135 0.0171 0.1275
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0135 0.0171 0.1325
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0104
Schistosoma mansoni survival motor neuron protein 0.0102 0.0124 0.0632
Onchocerca volvulus 0.0135 0.0171 0.3679
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0269 0.2035
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0027 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0033 0.0033
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0027 0.0027
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0646 0.0904 0.0904
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0919 0.1294 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0084 0.0099 0.0279
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0377 0.0518 0.5959
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0 0.0001
Trypanosoma brucei Casein kinase II 0.0145 0.0186 0.1992
Trichomonas vaginalis PIKK family atypical protein kinase 0.038 0.0523 0.4003
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0034 0.0907
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0084 0.0099 0.0712
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0023 0.0541
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0124 0.091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0108
Echinococcus granulosus casein kinase ii subunit alpha 0.0145 0.0186 0.0186
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0084 0.0099 0.0712
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0231 0.0309 0.3548
Brugia malayi Death domain containing protein 0.0015 0.0000070892 0.0001
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0269 0.2035
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0431 0.0595 0.4566
Echinococcus granulosus axis inhibition protein axin 0.002 0.0007 0.0007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.0099 0.0712
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.0269 0.0771
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Schistosoma mansoni hypothetical protein 0.0038 0.0033 0.0167
Toxoplasma gondii hypothetical protein 0.0035 0.0028 0.0318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0084 0.0099 0.0279
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0023 0.0134
Brugia malayi SH2 domain containing protein 0.036 0.0494 0.382
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0023 0.012
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.001 0.0024
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0019 0.0146
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0663 0.0928 0.0928
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0292 0.1672
Loa Loa (eye worm) hypothetical protein 0.0222 0.0296 0.1695
Loa Loa (eye worm) hypothetical protein 0.0107 0.0131 0.075
Plasmodium vivax hypothetical protein 0.0135 0.0171 0.5202
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0027 0.0027
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0048 0.0047 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0152 0.1125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0199 0.1491
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0008 0.0015
Entamoeba histolytica hypothetical protein 0.0038 0.0033 0.0198
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Brugia malayi PAS domain containing protein 0.0052 0.0052 0.0403
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0023 0.012
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0784 0.1101 0.8499
Giardia lamblia GTOR 0.0646 0.0904 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0048 0.0047 0.031
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0145 0.0186 0.5717
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0023 0.0541
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6998 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0121 0.0152 0.1125
Schistosoma mansoni hypothetical protein 0.0178 0.0233 0.1189
Schistosoma mansoni axis inhibition protein axin 0.002 0.0007 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.0489 0.3743
Loa Loa (eye worm) hypothetical protein 0.0132 0.0167 0.096
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0056 0.0372
Giardia lamblia Phosphatidylinositol 4-kinase 0.0135 0.0171 0.1687
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0023 0.012
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0008 0.0044
Entamoeba histolytica hypothetical protein 0.0135 0.0171 0.1275
Toxoplasma gondii CMGC kinase, CK2 family 0.0145 0.0186 0.2139
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0231 0.0309 0.234
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Onchocerca volvulus 0.0107 0.0131 0.2805
Loa Loa (eye worm) hypothetical protein 0.0173 0.0226 0.1295
Schistosoma mansoni hypothetical protein 0.0242 0.0325 0.1654
Brugia malayi Pre-SET motif family protein 0.0031 0.0023 0.0179
Echinococcus multilocularis cyclin dependent kinase 19 0.0142 0.0181 0.0181
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0132 0.0167 0.1294
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Echinococcus granulosus axis inhibition protein axin 0.002 0.0007 0.0007
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0072 0.0081 0.5423
Onchocerca volvulus 0.0249 0.0335 0.7193
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0035
Trypanosoma brucei polo-like protein kinase 0.0203 0.0269 0.2919
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0033 0.0167
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0054 0.0056 0.0056
Schistosoma mansoni axis inhibition protein axin 0.002 0.0007 0.0037
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0054 0.0056 0.0319
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0135 0.0171 0.0171
Loa Loa (eye worm) phosphatidylinositol 3 0.1234 0.1745 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0353 0.0483 0.3696
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0039 0.0034 0.0725
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0135 0.0171 0.1827
Echinococcus multilocularis serine protein kinase ATM 0.0357 0.0489 0.0489
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0341 0.0467 0.0467
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0663 0.0928 0.0928
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0027 0.0027
Echinococcus granulosus protein kinase shaggy 0.0054 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0007 0.0037
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0004 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0033 0.0033
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Schistosoma mansoni fkbp-rapamycin associated protein 0.0341 0.0467 0.2378
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0869 0.6695
Mycobacterium tuberculosis Conserved hypothetical protein 0.0135 0.0171 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0051 0.0336
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1386 0.1963 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0023 0.0258
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0309 0.0884
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.004 0.0205
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0019 0.0108
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0143 0.1056
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.015 0.0194 0.0552
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0038 0.0033 0.0198
Schistosoma mansoni regulator of G protein signaling 0.002 0.0007 0.0037
Entamoeba histolytica protein kinase domain containing protein 0.0145 0.0186 0.139
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0203 0.0269 0.073
Echinococcus granulosus expressed conserved protein 0.0086 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.008 0.0563
Mycobacterium leprae conserved hypothetical protein 0.0135 0.0171 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0023 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0056 0.0375
Schistosoma mansoni kinase 0.0105 0.0128 0.0653
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0919 0.1294 0.3733
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0135 0.0171 0.0873
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0231 0.0309 0.0838
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0161
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0056 0.0375
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0143 0.8035
Giardia lamblia Casein kinase II beta chain 0.0039 0.0034 0.0125
Entamoeba histolytica protein kinase rad3, putative 0.0341 0.0467 0.357
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0048 0.0047 0.0365
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0135 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.0876 0.675
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0007 0.0057
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0033 0.0033
Giardia lamblia Kinase, CMGC GSK 0.0054 0.0056 0.0372
Loa Loa (eye worm) hypothetical protein 0.0107 0.0131 0.0749
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Toxoplasma gondii target of rapamycin (TOR), putative 0.0622 0.0869 1
Brugia malayi Cytochrome P450 family protein 0.0021 0.0008 0.0059
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0919 0.1294 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0341 0.0466 0.267
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0383 0.0526 0.4064
Plasmodium falciparum casein kinase II beta chain 0.0039 0.0034 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.0876 0.675
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0341 0.0467 0.1342
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0143 0.1056
Echinococcus granulosus lamin dm0 0.0028 0.0019 0.0019
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0023 0.0258
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0646 0.0904 0.2605
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0636 0.089 0.089
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0054 0.0056 0.0283
Entamoeba histolytica hypothetical protein 0.0038 0.0033 0.0198
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0143 0.1056
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0181 0.0924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0385 0.053 0.4058
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0114 0.0579
Loa Loa (eye worm) calcium channel 0.0034 0.0027 0.0154
Loa Loa (eye worm) phosphatidylinositol 3 0.0595 0.083 0.4754
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0042
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0034 0.0206
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0028 0.1504
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0919 0.1294 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.1827
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0039 0.0034 0.009
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0039 0.0034 0.0206
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0143 0.1056
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Schistosoma mansoni voltage-gated cation channel 0.0034 0.0027 0.0137
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0084 0.0099 0.1019
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0092 0.011 0.011
Echinococcus multilocularis casein kinase ii subunit alpha 0.0145 0.0186 0.0186
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0084 0.0099 0.0712
Echinococcus granulosus lamin 0.0028 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0135 0.0171 0.0983
Loa Loa (eye worm) phosphatidylinositol 3 0.0135 0.0171 0.0983
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.0269 0.2035
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0007 0.0007
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0034 0.0027 0.0137
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0646 0.0904 0.2605
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0054 0.0056 0.0636
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Onchocerca volvulus 0.0102 0.0124 0.2663
Echinococcus granulosus geminin 0.0178 0.0233 0.0233
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0142 0.0181 0.1039
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0143 0.0385
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.086 0.1209 0.1209
Echinococcus multilocularis survival motor neuron protein 1 0.0499 0.0693 0.0693
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0383 0.0526 0.1513
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0052 0.0265
Leishmania major phosphatidylinositol 4-kinase, putative 0.0135 0.0171 0.0462
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0222 0.0296 0.0847
Plasmodium vivax casein kinase II beta chain, putative 0.0039 0.0034 0.0386
Schistosoma mansoni hypothetical protein 0.0102 0.0124 0.0632
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0646 0.0904 0.6967
Echinococcus multilocularis expressed protein 0.0396 0.0545 0.0545
Echinococcus granulosus tumor protein p63 0.0358 0.0491 0.0491
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0145 0.0186 0.1067
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0341 0.0466 0.267
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0034 0.0027 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0022 0.0021
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0023 0.0258
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0646 0.0904 0.4606
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0186 0.139
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0231 0.0309 0.1572
Trypanosoma cruzi casein kinase II, putative 0.0145 0.0186 0.0531
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0054 0.0056 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0622 0.0869 0.6695
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0023 0.5
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0027 0.0027
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0084 0.0099 0.0099
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0143 0.1513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0841 0.6478
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0000070892 0.0000000056599
Onchocerca volvulus 0.0038 0.0033 0.0705
Trichomonas vaginalis casein kinase II beta chain, putative 0.0039 0.0034 0.0206
Leishmania major phosphatidylinositol kinase, putative 0.0135 0.0171 0.0462
Echinococcus granulosus cyclin dependent kinase 19 0.0142 0.0181 0.0181
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0135 0.0171 0.5202
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0357 0.0489 0.1406
Loa Loa (eye worm) hypoxia-induced factor 1 0.016 0.0207 0.1185
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0231 0.0309 0.234
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0084 0.0099 0.1019
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0135 0.0171 0.1275
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0135 0.0171 0.1325
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0231 0.0309 0.0308
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0627 0.0876 0.2391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.0813 0.6262
Brugia malayi PXA domain containing protein 0.0022 0.0009 0.0073
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1386 0.1963 0.1962
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0063
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0583 0.0813 0.8988
Echinococcus multilocularis tumor protein p63 0.0358 0.0491 0.0491
Toxoplasma gondii hypothetical protein 0.0035 0.0028 0.0318
Entamoeba histolytica hypothetical protein 0.0135 0.0171 0.1275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0841 0.6479
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0383 0.0526 0.403
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0007 0.0057
Giardia lamblia Hypothetical protein 0.0135 0.0171 0.1687
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0186 0.139
Echinococcus granulosus casein kinase ii subunit beta 0.0039 0.0034 0.0034
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0135 0.0171 0.1325
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0135 0.0171 0.5462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.083 0.6389
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0135 0.0171 0.0171
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0143 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0084 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.036 0.0494 0.2833
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0231 0.0309 0.234
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0143 0.8035
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0034 0.0027 0.0027
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0231 0.0309 0.3548
Plasmodium falciparum GAF domain-related protein, putative 0.0035 0.0028 0.0715
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0767 0.1077 0.8311
Trichomonas vaginalis CMGC family protein kinase 0.0145 0.0186 0.139
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0084 0.0099 0.0712
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0007 0.0037
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.0337 0.1932
Brugia malayi hypothetical protein 0.0038 0.0033 0.0254
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0341 0.0466 0.36
Plasmodium falciparum glycogen synthase kinase 3 0.0054 0.0056 0.1627
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0023 0.0023
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0248 0.0333 0.0954
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0666 0.0932 0.7199
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0084 0.0099 0.0712
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.019 0.025 0.1929
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0383 0.0526 0.403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0646 0.0904 0.6967
Loa Loa (eye worm) phosphatidylinositol 3 0.0646 0.0904 0.518
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0595 0.083 0.2264

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 1 RFU min-1 Nucleocapsid p7 protein (NCp7) zinc finger domain reactivity was measured by Trp37 fluorescence assay expressed as the average decrease in relative fluorescence units over 30 min ChEMBL. 9888834
EC50 (functional) = 1.6 uM Effective antiviral concentration against HIV-1 infected CEM-SS cells ChEMBL. 9888834
IC50 (functional) = 21.7 uM Antiviral activity against HIV-1 infected CEM-SS cells was determined in XTT cytoprotection assay ChEMBL. 9888834
TI (ADMET) = 13.6 Therapeutic index (EC50 / IC50) ChEMBL. 9888834

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.