Detailed information for compound 305260

Basic information

Technical information
  • TDR Targets ID: 305260
  • Name: [(4Z)-4-hexylidene-2-(hydroxymethyl)-5-oxooxo lan-2-yl]methyl 4-methyl-3-propan-2-ylpentano ate
  • MW: 368.508 | Formula: C21H36O5
  • H donors: 1 H acceptors: 3 LogP: 4.98 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\1/CC(OC1=O)(CO)COC(=O)CC(C(C)C)C(C)C
  • InChi: 1S/C21H36O5/c1-6-7-8-9-10-17-12-21(13-22,26-20(17)24)14-25-19(23)11-18(15(2)3)16(4)5/h10,15-16,18,22H,6-9,11-14H2,1-5H3/b17-10-
  • InChiKey: SJBCBDAKOWZLGU-YVLHZVERSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(4Z)-4-hexylidene-2-(hydroxymethyl)-5-oxo-tetrahydrofuran-2-yl]methyl 3-isopropyl-4-methyl-pentanoate
  • 3-isopropyl-4-methylpentanoic acid [(4Z)-4-hexylidene-2-(hydroxymethyl)-5-oxo-2-tetrahydrofuranyl]methyl ester
  • [(4Z)-4-hexylidene-2-(hydroxymethyl)-5-oxo-oxolan-2-yl]methyl 4-methyl-3-propan-2-yl-pentanoate
  • 3-isopropyl-4-methyl-valeric acid [(4Z)-4-hexylidene-5-keto-2-methylol-tetrahydrofuran-2-yl]methyl ester
  • NSC703747

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protein jagged 1 0.0166 0.1228 0.1224
Echinococcus multilocularis fat cadherin tumor suppressor 0.0166 0.1228 0.1224
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0009 0.002 0.0036
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0166 0.0484
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0059 0.0403 0.0399
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0049 0.033 0.0835
Onchocerca volvulus 0.0514 0.3905 1
Brugia malayi Pleckstrin Homology Domain 0.0007 0.0007 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0027 0.0162 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0065 0.0155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0088 0.0627 0.1387
Trichomonas vaginalis ran, putative 0.0018 0.009 0.3897
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Loa Loa (eye worm) hypothetical protein 0.0044 0.0288 0.0728
Echinococcus multilocularis neural cadherin 0.0166 0.1228 0.1224
Brugia malayi RhoGEF domain containing protein 0.0007 0.0007 0.0006
Onchocerca volvulus Peroxidasin homolog 0.0514 0.3905 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0346
Brugia malayi Importin beta-1 subunit 0.0025 0.0139 0.0346
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0027 0.0162 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0078
Schistosoma mansoni hypothetical protein 0.0112 0.0812 0.1799
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Schistosoma mansoni hypothetical protein 0.0052 0.0349 0.0768
Echinococcus granulosus neurogenic locus notch protein 4 0.0166 0.1228 0.2724
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0017
Brugia malayi MH2 domain containing protein 0.0013 0.0051 0.0118
Echinococcus multilocularis notch 0.0166 0.1228 0.1224
Schistosoma mansoni hypothetical protein 0.0052 0.0349 0.0768
Brugia malayi follicle stimulating hormone receptor 0.0199 0.1484 0.3794
Schistosoma mansoni polypyrimidine tract binding protein 0.0011 0.0035 0.0068
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0017
Leishmania major GTP-binding protein, putative 0.0018 0.009 0.2452
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0349 0.0885
Schistosoma mansoni hypothetical protein 0.0059 0.0403 0.0888
Schistosoma mansoni hypothetical protein 0.0166 0.1228 0.2724
Echinococcus granulosus transmembrane protease serine 3 0.0009 0.002 0.0036
Brugia malayi Delta serrate ligand family protein 0.0166 0.1228 0.3137
Echinococcus multilocularis GPCR, family 2 0.0052 0.0349 0.0345
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0009 0.0023 0.0736
Echinococcus granulosus cpg binding protein 0.0044 0.0288 0.0631
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0065 0.0135
Onchocerca volvulus 0.0035 0.0219 0.0549
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0166 0.1228 0.2724
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0065 0.0155
Brugia malayi MH2 domain containing protein 0.0013 0.0051 0.0118
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0119 0.7043
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0413
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.0104 0.0753 0.1921
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0413
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0139 0.0404
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Brugia malayi EGF-like domain containing protein 0.0166 0.1228 0.3137
Entamoeba histolytica protein kinase, putative 0.001 0.003 0.0586
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0007 0.0006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0026 0.0148 0.0144
Schistosoma mansoni peroxidasin 0.0514 0.3905 0.8682
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Echinococcus granulosus myotubularin protein 13 0.0007 0.0007 0.0005
Echinococcus multilocularis Rac GTPase activating protein 1 0.0007 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Echinococcus granulosus tumor protein p63 0.03 0.2259 0.5019
Brugia malayi Protein kinase domain containing protein 0.001 0.003 0.0065
Schistosoma mansoni cpg binding protein 0.0044 0.0288 0.0631
Schistosoma mansoni Smad4 0.0013 0.0051 0.0103
Echinococcus multilocularis neurogenic locus protein delta 0.0166 0.1228 0.1224
Echinococcus multilocularis neurogenic locus protein delta 0.0166 0.1228 0.1224
Echinococcus multilocularis protein jagged 1 0.0166 0.1228 0.1224
Schistosoma mansoni protein kinase C mu 0.0007 0.0007 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0205 0.0446
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0365 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0065 0.0155
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0413
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0026 0.0148 0.0321
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0119 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0018 0.0496
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0166 0.0484
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0205 0.0201
Echinococcus multilocularis neurogenic locus notch protein 0.0166 0.1228 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Echinococcus granulosus notch 0.0166 0.1228 0.2724
Leishmania major RNA-binding protein, putative 0.0008 0.0014 0.0374
Brugia malayi Smad1 0.0013 0.0051 0.0118
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0009 0.002 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.1211 0.3095
Onchocerca volvulus 0.0028 0.0166 0.0413
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0009 0.0018 0.0497
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0166 0.1228 0.3137
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0051 0.0103
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0065 0.0135
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0098 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Schistosoma mansoni hypothetical protein 0.0052 0.0349 0.0768
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0026 0.0148 0.3573
Echinococcus granulosus slit 2 protein 0.0166 0.1228 0.2724
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Brugia malayi Animal haem peroxidase family protein 0.0514 0.3905 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0049 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Echinococcus granulosus importin subunit beta 1 0.0025 0.0139 0.0301
Entamoeba histolytica hypothetical protein 0.0059 0.0403 1
Brugia malayi EGF-like domain containing protein 0.0166 0.1228 0.3137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0023 0.0736
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0166 0.1228 0.2724
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Echinococcus granulosus peroxidasin 0.0514 0.3905 0.8682
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0065 0.0135
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0365 0.0803
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0166 0.0484
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0015 0.0065 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.001 0.003 0.0057
Schistosoma mansoni polypyrimidine tract binding protein 0.0008 0.0014 0.0021
Schistosoma mansoni topbp1 0.0009 0.0018 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0119 0.0295
Toxoplasma gondii PAN/Apple domain-containing protein 0.0028 0.0166 0.0484
Loa Loa (eye worm) hypothetical protein 0.0084 0.0599 0.1525
Schistosoma mansoni unc-13 (munc13) 0.0009 0.0018 0.0031
Echinococcus granulosus ubiquitin specific protease 41 0.0026 0.0148 0.0321
Schistosoma mansoni vav2 0.0007 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.05
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.1211 0.3095
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0065 0.0155
Onchocerca volvulus Peroxidasin homolog 0.0514 0.3905 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0004
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0027 0.0162 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0026 0.0148 0.108
Brugia malayi protein kinase C II. 0.0019 0.0098 0.0239
Trypanosoma cruzi polypyrimidine tract-binding protein, putative 0.0011 0.0035 0.2154
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0008 0.0008 0.001
Toxoplasma gondii hypothetical protein 0.0028 0.0166 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0049 0.01
Entamoeba histolytica hypothetical protein 0.002 0.0104 0.2447
Onchocerca volvulus 0.0009 0.002 0.0041
Onchocerca volvulus 0.0015 0.0065 0.0155
Schistosoma mansoni protein kinase C 0.0009 0.0018 0.0031
Echinococcus granulosus protein jagged 1 0.0166 0.1228 0.2724
Brugia malayi RhoGAP domain containing protein 0.0007 0.0007 0.0006
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0065 0.0135
Echinococcus granulosus geminin 0.0413 0.3126 0.6949
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0264 0.0577
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0007 0.0007
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0028 0.0166 0.0484
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0139 0.8611
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0065 0.0155
Entamoeba histolytica Ran family GTPase 0.0018 0.009 0.209
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0041
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0009 0.0018 0.5
Schistosoma mansoni notch 0.0166 0.1228 0.2724
Echinococcus granulosus neural cadherin 0.0166 0.1228 0.2724
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.001 0.0028 0.0991
Loa Loa (eye worm) transcription factor SMAD2 0.0191 0.1421 0.3631
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Echinococcus granulosus enteropeptidase 0.0009 0.002 0.0036
Echinococcus granulosus Rac GTPase activating protein 1 0.0007 0.0007 0.0005
Echinococcus granulosus unc 13 munc13 0.0009 0.0018 0.0031
Echinococcus granulosus neuropeptide receptor A26 0.0395 0.2992 0.6651
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) raf kinase 0.0007 0.0007 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0065 0.0135
Schistosoma mansoni hypothetical protein 0.0413 0.3126 0.6949
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0036
Schistosoma mansoni polypyrimidine tract binding protein 0.0011 0.0035 0.0068
Schistosoma mansoni peroxidasin 0.0514 0.3905 0.8682
Schistosoma mansoni serine/threonine kinase 0.001 0.003 0.0057
Toxoplasma gondii microneme protein MIC17C 0.0028 0.0166 0.0484
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0007 0.0006
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0166 0.0413
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0317 0.0313
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0065 0.0135
Trichomonas vaginalis importin beta-1, putative 0.002 0.0104 0.4567
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0065 0.0135
Toxoplasma gondii isocitrate dehydrogenase 0.0027 0.0162 0.0473
Schistosoma mansoni notch 0.0166 0.1228 0.2724
Brugia malayi Calcium binding EGF domain containing protein 0.0166 0.1228 0.3137
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0051 0.0046
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0007 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0065 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0065 0.0155
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0264 0.0577
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0051 0.0118
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0007 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0065 0.0135
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0008 0.0008 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0027 0.0162 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0026 0.0148 0.0321
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0054 0.0365 0.0803
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0065 0.006
Echinococcus multilocularis smad 0.0013 0.0051 0.0046
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0139 0.8611
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0413
Echinococcus multilocularis lamin dm0 0.0086 0.0611 0.0607
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0009 0.0018 0.0031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0269 0.0679
Schistosoma mansoni cpg binding protein 0.0041 0.027 0.059
Echinococcus multilocularis serine:threonine protein kinase N2 0.001 0.003 0.0025
Schistosoma mansoni smad 0.0013 0.0051 0.0103
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.009 0.0594
Onchocerca volvulus 0.0009 0.0018 0.0036
Onchocerca volvulus Dual oxidase homolog 0.0514 0.3905 1
Brugia malayi Trypsin family protein 0.0009 0.002 0.0041
Entamoeba histolytica protein kinase, putative 0.001 0.003 0.0586
Toxoplasma gondii AGC kinase 0.001 0.003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) AGC/NDR protein kinase 0.001 0.003 0.0065
Brugia malayi hypothetical protein 0.0104 0.0753 0.1921
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.0007 0.0003
Loa Loa (eye worm) animal heme peroxidase 0.0514 0.3905 1
Echinococcus granulosus lamin 0.0086 0.0611 0.1351
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0269 0.059
Brugia malayi isocitrate dehydrogenase 0.0027 0.0162 0.0404
Brugia malayi Protein kinase c protein 2 0.0057 0.0386 0.0979
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0007 0.0003
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0007 0.0006
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0166 0.0413
Onchocerca volvulus Bile acid receptor homolog 0.0015 0.0065 0.0155
Brugia malayi MH1 domain containing protein 0.0013 0.0051 0.0118
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0009 0.0018 0.028
Onchocerca volvulus 0.0009 0.002 0.0041
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.009 0.0189
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0026 0.0148 0.0144
Brugia malayi hypothetical protein 0.0514 0.3905 1
Plasmodium vivax polypyrimidine tract binding protein, putative 0.0011 0.0035 0.1191
Schistosoma mansoni diacylglycerol kinase theta 0.0007 0.0007 0.0005
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0065 0.0135
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0166 0.0413
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0009 0.002 0.0016
Brugia malayi C1-like domain containing protein 0.0008 0.0008 0.001
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0026 0.0148 0.0321
Brugia malayi DKFZp564C0469 protein 0.0009 0.0018 0.0034
Schistosoma mansoni hypothetical protein 0.0166 0.1228 0.2724
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0349 0.0768
Schistosoma mansoni unc-13 (munc13) 0.0012 0.0044 0.0088
Schistosoma mansoni hypothetical protein 0.0591 0.4496 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0413
Schistosoma mansoni transcription factor LCR-F1 0.0059 0.0403 0.0888
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0065 0.006
Brugia malayi CXXC zinc finger family protein 0.0041 0.027 0.068
Echinococcus granulosus protein kinase c eta type 0.0007 0.0007 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0349 0.0345
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.001 0.003 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0034 0.0065
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0218 1
Schistosoma mansoni ran 0.0018 0.009 0.0189
Onchocerca volvulus 0.0166 0.1228 0.3137
Schistosoma mansoni hypothetical protein 0.0009 0.002 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0008 0.0009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0008 0.0011 0.0014
Mycobacterium ulcerans hypothetical protein 0.0009 0.002 0.0077
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0065 0.006
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0317 0.0313
Brugia malayi hypothetical protein 0.0059 0.0403 0.1023
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0034 0.0065
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Trypanosoma cruzi FHA domain containing protein, putative 0.0009 0.0018 0.1093
Toxoplasma gondii microneme protein MIC17B 0.0028 0.0166 0.0484
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0065 0.0135
Brugia malayi hypothetical protein 0.0008 0.0011 0.0017
Echinococcus multilocularis unc 13 (munc13) 0.0009 0.0018 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0464 0.1023
Schistosoma mansoni hypothetical protein 0.0022 0.0119 0.0256
Giardia lamblia High cysteine protein 0.0166 0.1228 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.009 0.553
Onchocerca volvulus 0.0041 0.027 0.068
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.0098 0.0208
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0018 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0065 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0065 0.0155
Schistosoma mansoni notch 0.0166 0.1228 0.2724
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0041
Brugia malayi Animal haem peroxidase family protein 0.0514 0.3905 1
Brugia malayi Animal haem peroxidase family protein 0.0514 0.3905 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.009 0.4981
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0051 0.0103
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0269 0.0265
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Brugia malayi nuclear receptor NHR-88 0.0015 0.0065 0.0155
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0008 0.0011 0.0017
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0026 0.0148 0.9166
Brugia malayi Trypsin family protein 0.0009 0.002 0.0041
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0065 0.0135
Echinococcus granulosus Diacylglycerol kinase theta 0.0007 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0018 0.0496
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.0205 0.0514
Echinococcus granulosus snurportin 1 0.0262 0.1968 0.4371
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0034 0.0029
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Brugia malayi MH1 domain containing protein 0.0007 0.0006 0.0004
Echinococcus multilocularis Regulator of differentiation 1 0.0011 0.0035 0.003
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0812 0.2072
Onchocerca volvulus Chorion peroxidase homolog 0.0514 0.3905 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0011 0.0017
Brugia malayi Blistered cuticle protein 3 0.0514 0.3905 1
Onchocerca volvulus 0.0008 0.0014 0.0024
Brugia malayi p70 ribosomal S6 kinase beta 0.001 0.003 0.0065
Echinococcus multilocularis protein jagged 2 0.0166 0.1228 0.1224
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.009 0.0218
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Brugia malayi Protein kinase domain containing protein 0.0022 0.0119 0.0295
Brugia malayi Ras association domain family 1 isoform A 0.0007 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0413 0.3126 0.6949
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0054 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0041
Schistosoma mansoni lamin 0.0086 0.0611 0.1351
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0166 0.0413
Onchocerca volvulus Peroxidase homolog 0.0514 0.3905 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.001 0.003 0.0057
Onchocerca volvulus 0.0028 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Schistosoma mansoni hypothetical protein 0.0262 0.1968 0.4371
Schistosoma mansoni rac gtpase activating protein 0.0007 0.0007 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0018 0.1093
Brugia malayi steroid hormone receptor 0.0015 0.0065 0.0155
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Onchocerca volvulus 0.0166 0.1228 0.3137
Brugia malayi diacylglycerol kinase 0.0007 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0018 0.0496
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.001 0.003 0.0025
Onchocerca volvulus 0.0007 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0148 0.6683
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0349 0.0885
Loa Loa (eye worm) nuclear factor I 0.0007 0.0006 0.0004
Brugia malayi hypothetical protein 0.0009 0.002 0.0041
Echinococcus multilocularis neurogenic locus notch protein 4 0.0166 0.1228 0.1224
Brugia malayi diacylglycerol kinase 0.0007 0.0007 0.0006
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0009 0.0018 0.5
Schistosoma mansoni ran 0.0018 0.009 0.0189
Onchocerca volvulus 0.0028 0.0166 0.0413
Echinococcus granulosus GPCR family 2 0.0052 0.0349 0.0768
Brugia malayi Protein kinase domain containing protein 0.001 0.003 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0065 0.0135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0205 0.0201
Onchocerca volvulus 0.0009 0.002 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0065 0.0155
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0027 0.0162 0.0351
Echinococcus multilocularis serine:threonine protein kinase N2 0.001 0.003 0.0025
Schistosoma mansoni cellular tumor antigen P53 0.0044 0.0288 0.0632
Schistosoma mansoni coup transcription factor 0.0015 0.0065 0.0135
Echinococcus multilocularis isocitrate dehydrogenase 0.0027 0.0162 0.0158
Loa Loa (eye worm) hypothetical protein 0.0086 0.0611 0.1556
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0048 0.0112
Onchocerca volvulus 0.0028 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.001 0.003 0.0065
Onchocerca volvulus 0.0514 0.3905 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0017
Schistosoma mansoni smad1 5 8 and 0.0013 0.0051 0.0103
Brugia malayi topoisomerase 0.0009 0.0018 0.0034
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Schistosoma mansoni hypothetical protein 0.0009 0.002 0.0036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0026 0.0148 0.4063
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0065 0.0155
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0007 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0349 0.0885
Loa Loa (eye worm) notch protein 0.0166 0.1228 0.3137
Trichomonas vaginalis helicase, putative 0.0009 0.0023 0.0736
Brugia malayi hypothetical protein 0.0009 0.0018 0.0034
Toxoplasma gondii aldehyde dehydrogenase 0.0054 0.0365 0.1091
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0026 0.0148 0.0369
Trypanosoma brucei Double RNA binding domain protein 3 0.0008 0.0014 0.0843
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0027 0.0162 0.0158
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0034 0.0075
Loa Loa (eye worm) AGC/PKN protein kinase 0.001 0.003 0.0065
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0026 0.0148 0.6683
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0611 0.1556
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0009 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0129 0.0941 0.2401
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0119 0.7366
Schistosoma mansoni cell polarity protein 0.0166 0.1228 0.2724
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0036
Echinococcus multilocularis ubiquitin specific protease 41 0.0026 0.0148 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0018 0.0496
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.001 0.003 0.0065
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0139 0.0135
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0065 0.0135
Schistosoma mansoni smad1 5 8 and 0.0013 0.0051 0.0103
Echinococcus multilocularis musashi 0.0086 0.0611 0.0607
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0065 0.006
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Brugia malayi Animal haem peroxidase family protein 0.0514 0.3905 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0065 0.0135
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0009 0.002 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0065 0.006
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0648
Echinococcus granulosus Protein kinase C brain isozyme 0.0067 0.0464 0.1023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0349 0.0768
Brugia malayi notch-like transmembrane receptor 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Leishmania major hypothetical protein, conserved 0.0022 0.0119 0.3266
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Schistosoma mansoni notch 0.0166 0.1228 0.2724
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0011 0.0014
Schistosoma mansoni notch 0.0166 0.1228 0.2724
Schistosoma mansoni topbp1 0.0009 0.0018 0.003
Onchocerca volvulus 0.0028 0.0166 0.0413
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0049 0.0115
Schistosoma mansoni laminin gamma-3 chain 0.0166 0.1228 0.2724
Toxoplasma gondii PAN domain-containing protein 0.0434 0.3293 1
Entamoeba histolytica hypothetical protein 0.0059 0.0403 1
Schistosoma mansoni serine/threonine protein kinase 0.001 0.003 0.0057
Brugia malayi nuclear receptor RXR 0.0008 0.0011 0.0017
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0009 0.0018 0.0496
Echinococcus multilocularis neuropeptide receptor A26 0.0395 0.2992 0.2989
Schistosoma mansoni cpg binding protein 0.0044 0.0288 0.0631
Brugia malayi EGF-like domain containing protein 0.0166 0.1228 0.3137
Brugia malayi Hr1 repeat family protein 0.001 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0007 0.0006
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0009 0.0018 0.1093
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0026 0.0148 0.0321
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0237 0.0597
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0023 0.0736
Echinococcus granulosus Regulator of differentiation 1 0.0011 0.0035 0.0068
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0016
Brugia malayi Kringle domain containing protein 0.0022 0.0119 0.0295
Echinococcus multilocularis glycoprotein Antigen 5 0.0009 0.002 0.0016
Schistosoma mansoni slit 0.0166 0.1228 0.2724
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.0007 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0349 0.0345
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0007 0.0003
Echinococcus multilocularis transmembrane protease serine 3 0.0009 0.002 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0065 0.0155
Toxoplasma gondii subtilisin SUB12 0.0028 0.0166 0.0484
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0036
Echinococcus granulosus NDR protein kinase 0.001 0.003 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0065 0.0135
Chlamydia trachomatis DNA ligase 0.0009 0.0018 0.5
Schistosoma mansoni intermediate filament proteins 0.0086 0.0611 0.1351
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Echinococcus multilocularis serine threonine protein kinase 0.0059 0.0408 0.0404
Toxoplasma gondii microneme protein, putative 0.0028 0.0166 0.0484
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.009 0.0218
Onchocerca volvulus 0.0028 0.0166 0.0413
Schistosoma mansoni importin beta-1 0.0025 0.0139 0.0301
Loa Loa (eye worm) hypothetical protein 0.0171 0.1266 0.3234
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0034 0.0065
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Toxoplasma gondii PAN domain-containing protein 0.0028 0.0166 0.0484
Onchocerca volvulus 0.0007 0.0007 0.0006
Echinococcus granulosus protein kinase c iota type 0.0018 0.0086 0.0182
Brugia malayi EGF-like domain containing protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0034
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0026 0.0148 0.9166
Brugia malayi protein kinase C3,putative 0.0008 0.0008 0.001
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0007 0.0006
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0119 0.0343
Echinococcus multilocularis replication factor c subunit 1 0.0009 0.0018 0.0013
Schistosoma mansoni atypical protein kinase C 0.0018 0.0086 0.0182
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0065 0.0135
Onchocerca volvulus Protein ultraspiracle homolog 0.0015 0.0065 0.0155
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0007 0.0007
Loa Loa (eye worm) AGC/AKT protein kinase 0.001 0.003 0.0065
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.009 0.0252
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0008 0.0011 0.0006
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0041
Echinococcus multilocularis snurportin 1 0.0262 0.1968 0.1965
Echinococcus granulosus protein jagged 1 0.0166 0.1228 0.2724
Brugia malayi Trypsin family protein 0.0009 0.002 0.0041
Onchocerca volvulus Peroxidase homolog 0.0514 0.3905 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0024
Echinococcus granulosus intermediate filament protein 0.0086 0.0611 0.1351
Onchocerca volvulus Neurogenic locus notch homolog 0.0166 0.1228 0.3137
Brugia malayi Pax transcription activation domain interacting protein 0.0009 0.0018 0.0034
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0019 0.0098 0.0239
Brugia malayi hypothetical protein 0.0009 0.0018 0.0034
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0034 0.0029
Brugia malayi Isocitrate dehydrogenase 0.0027 0.0162 0.0404
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0041
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0009 0.0018 0.0014
Schistosoma mansoni septate junction protein 0.0166 0.1228 0.2724
Loa Loa (eye worm) isocitrate dehydrogenase 0.0027 0.0162 0.0404
Onchocerca volvulus 0.0028 0.0166 0.0413
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.0007 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0024
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.0098 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0065 0.0155
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Echinococcus granulosus nibrin 0.0009 0.0018 0.003
Brugia malayi RhoGAP domain containing protein 0.0007 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0065 0.0155
Onchocerca volvulus 0.0166 0.1228 0.3137
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0009 0.0018 0.0034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.0205 0.0514
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0007 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0034 0.0065
Toxoplasma gondii microneme protein MIC4 0.0028 0.0166 0.0484
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Brugia malayi hypothetical protein 0.0008 0.0011 0.0017
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0119 0.7043
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0007 0.0006
Brugia malayi nuclear hormone receptor 0.0015 0.0065 0.0155
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Echinococcus granulosus protein kinase C gamma type 0.0059 0.0408 0.0898
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0041
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.009 0.553
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.003 0.0056
Leishmania major hypothetical protein, conserved 0.0008 0.0014 0.0374
Echinococcus multilocularis slit 2 protein 0.0166 0.1228 0.1224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0205 0.0446
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Onchocerca volvulus 0.0086 0.0611 0.1556
Echinococcus multilocularis survival motor neuron protein 1 0.0171 0.1266 0.1262
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0036
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0611 0.1556
Brugia malayi Cadherin domain containing protein 0.0166 0.1228 0.3137
Brugia malayi intermediate filament protein 0.0086 0.0611 0.1556
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0119 0.0256
Brugia malayi Muscle positioning protein 4 0.0166 0.1228 0.3137
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0219 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0205 0.0446
Echinococcus granulosus dnaJ subfamily B 0.0591 0.4496 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0812 0.2072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0036
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.0007 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0051 0.0118
Loa Loa (eye worm) MH2 domain-containing protein 0.0191 0.1421 0.3631
Echinococcus granulosus protein jagged 2 0.0166 0.1228 0.2724
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0413
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0065 0.0155
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Onchocerca volvulus 0.0028 0.0166 0.0413
Onchocerca volvulus 0.0129 0.0941 0.2401
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0065 0.006
Schistosoma mansoni hypothetical protein 0.0052 0.0349 0.0768
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0023 0.0736
Echinococcus multilocularis protein kinase c iota type 0.0018 0.0086 0.0082
Toxoplasma gondii microneme protein MIC17A 0.0028 0.0166 0.0484
Loa Loa (eye worm) PAN domain-containing protein 0.0028 0.0166 0.0413
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0317 0.0695
Onchocerca volvulus 0.0028 0.0166 0.0413
Entamoeba histolytica hypothetical protein 0.0009 0.0018 0.028
Schistosoma mansoni hypothetical protein 0.0166 0.1228 0.2724
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.001 0.003 0.0065
Schistosoma mansoni smad1 5 8 and 0.0013 0.0051 0.0103
Brugia malayi Calcium binding EGF domain containing protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Brugia malayi hypothetical protein 0.0129 0.0941 0.2401
Onchocerca volvulus 0.0028 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0369
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0065 0.0135
Brugia malayi EGF-like domain containing protein 0.0166 0.1228 0.3137
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0008 0.0009
Echinococcus granulosus N chimaerin 0.0007 0.0007 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0365 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.001 0.003 0.0065
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.001 0.003 0.0057
Loa Loa (eye worm) animal heme peroxidase 0.0514 0.3905 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0027 0.0162 0.4433
Onchocerca volvulus Huntingtin homolog 0.0104 0.0753 0.1921
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0065 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0023 0.0736
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0065 0.006
Schistosoma mansoni notch 0.0166 0.1228 0.2724
Onchocerca volvulus Putative cubilin 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0034
Toxoplasma gondii EGF family domain-containing protein 0.0166 0.1228 0.3716
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0027 0.0162 0.0158
Loa Loa (eye worm) hypothetical protein 0.0104 0.0753 0.1921
Toxoplasma gondii hypothetical protein 0.0028 0.0166 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.001 0.003 0.0057
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0413
Echinococcus multilocularis N chimaerin 0.0007 0.0007 0.0002
Onchocerca volvulus 0.0009 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0009 0.0023 0.0736
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0065 0.0135
Schistosoma mansoni diacylglycerol kinase theta 0.0007 0.0007 0.0005
Echinococcus multilocularis enteropeptidase 0.0009 0.002 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0365 0.0803
Onchocerca volvulus 0.0514 0.3905 1
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0027 0.0162 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.009 0.4981
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0007 0.0007 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0065 0.006
Brugia malayi EGF-like domain containing protein 0.0166 0.1228 0.3137
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0104 0.4567
Schistosoma mansoni protein kinase C mu 0.0008 0.0008 0.0009
Entamoeba histolytica hypothetical protein 0.0059 0.0403 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0026 0.0148 0.9166
Brugia malayi RNA, U transporter 1 0.007 0.0488 0.124
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.003 0.0025
Echinococcus granulosus glycoprotein Antigen 5 0.0009 0.002 0.0036
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0237 0.0519
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0054 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0034
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0007 0.0007 0.0006
Echinococcus granulosus fibropellin Ia 0.0166 0.1228 0.2724
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Brugia malayi EGF-like domain containing protein 0.0166 0.1228 0.3137
Echinococcus granulosus protein jagged 2 0.0166 0.1228 0.2724
Toxoplasma gondii ATPase, AAA family protein 0.0009 0.0018 0.0034
Brugia malayi MH1 domain containing protein 0.0013 0.0051 0.0118
Brugia malayi Peroxidasin 0.0514 0.3905 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0007 0.0007 0.0005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0027 0.0162 1
Onchocerca volvulus 0.0086 0.0611 0.1556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0205 0.0446
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.003 0.0056
Loa Loa (eye worm) Smad1 0.0013 0.0051 0.0118
Echinococcus multilocularis tumor protein p63 0.03 0.2259 0.2255
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Toxoplasma gondii isocitrate dehydrogenase 0.0027 0.0162 0.0473
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0059 0.0403 0.0888
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0104 0.6404
Onchocerca volvulus 0.0009 0.002 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0065 0.0155
Echinococcus granulosus Mastin 0.0009 0.002 0.0036
Onchocerca volvulus 0.0166 0.1228 0.3137
Brugia malayi GCC2 and GCC3 family protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0007 0.0007 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0023 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0237 0.0233
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.009 0.553
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Echinococcus granulosus neuropeptide s receptor 0.0395 0.2992 0.6651
Echinococcus granulosus Smad4 0.0013 0.0051 0.0103
Echinococcus multilocularis nibrin 0.0009 0.0018 0.0013
Echinococcus multilocularis neuropeptide s receptor 0.0395 0.2992 0.2989
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Brugia malayi ecdysteroid receptor 0.0015 0.0065 0.0155
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Echinococcus multilocularis Mastin 0.0009 0.002 0.0016
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0008 0.0008 0.001
Brugia malayi MH2 domain containing protein 0.0191 0.1421 0.3631
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0065 0.0135
Loa Loa (eye worm) hypothetical protein 0.0164 0.1211 0.3095
Echinococcus multilocularis Diacylglycerol kinase theta 0.0007 0.0007 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0514 0.3905 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0051 0.0046
Schistosoma mansoni hypothetical protein 0.0035 0.0219 0.0477
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0199 0.1484 0.3794
Echinococcus multilocularis raf serine:threonine protein kinase 0.0007 0.0007 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0065 0.0155
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0008 0.0011 0.0014
Echinococcus granulosus smad 0.0013 0.0051 0.0103
Entamoeba histolytica protein kinase, putative 0.001 0.003 0.0586
Trypanosoma cruzi Double RNA binding domain protein 3 0.0008 0.0014 0.0843
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.0007 0.0006
Echinococcus multilocularis dnaJ subfamily B 0.0591 0.4496 0.4494
Brugia malayi Protein kinase domain containing protein 0.0008 0.0008 0.001
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0027 0.0162 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0007 0.0006
Plasmodium falciparum importin beta, putative 0.0025 0.0139 0.8441
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.009 0.0085
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0304 0.0769
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0011 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0065 0.0155
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0262 0.1968 0.5035
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Entamoeba histolytica protein kinase, putative 0.001 0.003 0.0586
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0007 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0218 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0007 0.0007 0.0005
Echinococcus multilocularis geminin 0.0413 0.3126 0.3123
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0304 0.0769
Schistosoma mansoni DNA ligase IV 0.0009 0.0018 0.003
Schistosoma mansoni survival motor neuron protein 0.0035 0.0219 0.0477
Brugia malayi Trypsin family protein 0.0009 0.002 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0065 0.0155
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0166 0.1228 0.2724
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0017
Echinococcus granulosus lamin dm0 0.0086 0.0611 0.1351
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0237 0.0597
Toxoplasma gondii PAN domain-containing protein 0.0434 0.3293 1
Echinococcus granulosus delta-like protein 1 0.0166 0.1228 0.2724
Schistosoma mansoni serine/threonine protein kinase 0.001 0.003 0.0057
Brugia malayi Cadherin domain containing protein 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Onchocerca volvulus 0.0166 0.1228 0.3137
Onchocerca volvulus Slit protein homolog 0.0166 0.1228 0.3137
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0027 0.0162 0.0351
Loa Loa (eye worm) Notch2 0.0166 0.1228 0.3137
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0166 0.1228 0.3137
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0009 0.0018 0.0496
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0009 0.0018 0.0034
Onchocerca volvulus 0.0028 0.0166 0.0413
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0027 0.0162 0.0158
Brugia malayi Calcium binding EGF domain containing protein 0.0166 0.1228 0.3137
Echinococcus multilocularis fibropellin Ia 0.0166 0.1228 0.1224
Loa Loa (eye worm) hypothetical protein 0.0048 0.0317 0.0801
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0054 0.0365 0.0361
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0065 0.0135
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0008 0.0008 0.001
Onchocerca volvulus Huntingtin homolog 0.0104 0.0753 0.1921
Echinococcus multilocularis myotubularin protein 13 0.0007 0.0007 0.0002
Echinococcus multilocularis peroxidasin 0.0514 0.3905 0.3902
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.001 0.003 0.0065
Treponema pallidum DNA ligase (lig) 0.0009 0.0018 0.5
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0611 0.1556
Echinococcus multilocularis protein kinase c eta type 0.0007 0.0007 0.0002
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0009 0.0018 0.1093
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Loa Loa (eye worm) hypothetical protein 0.0011 0.0034 0.0075
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.001 0.003 0.0057
Echinococcus multilocularis cpg binding protein 0.0044 0.0288 0.0284
Schistosoma mansoni cercarial elastase (S01 family) 0.0009 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0166 0.1228 0.2724
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0119 0.0295
Echinococcus granulosus serine:threonine protein kinase N2 0.001 0.003 0.0057
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Trypanosoma brucei rac serine-threonine kinase, putative 0.001 0.003 0.1845
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0005
Leishmania major importin beta-1 subunit, putative 0.002 0.0104 0.2839
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0026 0.0148 0.6683
Schistosoma mansoni hypothetical protein 0.0166 0.1228 0.2724
Onchocerca volvulus 0.0009 0.0018 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0065 0.0155
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.001 0.003 0.0025
Trypanosoma brucei Double RNA-binding domain containing protein 4 0.0011 0.0035 0.2154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0065 0.0155
Plasmodium falciparum polypyrimidine tract-binding protein, putative 0.0011 0.0035 0.1191
Loa Loa (eye worm) trypsin family protein 0.0009 0.002 0.0041
Trichomonas vaginalis replication factor C large subunit, putative 0.0009 0.0018 0.0497
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.1211 0.3095
Plasmodium vivax importin-beta 2, putative 0.0025 0.0139 0.8441
Echinococcus granulosus neurogenic locus protein delta 0.0166 0.1228 0.2724
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0065 0.0135
Echinococcus granulosus neurogenic locus notch protein 0.0166 0.1228 0.2724
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0065 0.0155
Echinococcus granulosus neurogenic locus notch protein 0.0166 0.1228 0.2724
Brugia malayi Animal haem peroxidase family protein 0.0514 0.3905 1
Trichomonas vaginalis AGC family protein kinase 0.001 0.003 0.1073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Loa Loa (eye worm) hypothetical protein 0.004 0.0257 0.0648
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0464 0.1023
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0009 0.0018 0.0497
Loa Loa (eye worm) hypothetical protein 0.0008 0.0011 0.0017
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Toxoplasma gondii RNA recognition motif-containing protein 0.0011 0.0035 0.0086
Schistosoma mansoni lamin 0.0086 0.0611 0.1351
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0104 0.4567
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0349 0.0885
Echinococcus granulosus replication factor c subunit 1 0.0009 0.0018 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0023 0.0736
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0008 0.0008 0.0009
Schistosoma mansoni chromosome transmission fidelity factor 0.0009 0.0018 0.003
Onchocerca volvulus 0.0022 0.0119 0.0295
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0051 0.0103
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0007 0.0007 0.0002
Brugia malayi hypothetical protein 0.0171 0.1266 0.3234
Echinococcus multilocularis serine:threonine protein kinase 38 0.001 0.003 0.0025
Onchocerca volvulus 0.0044 0.0288 0.0728
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0065 0.0155
Toxoplasma gondii histone lysine methyltransferase SET1 0.0079 0.0555 0.1669
Loa Loa (eye worm) CXXC zinc finger family protein 0.0041 0.027 0.068
Entamoeba histolytica hypothetical protein 0.0059 0.0403 1
Brugia malayi Trypsin-like protease protein 5 0.0009 0.002 0.0041
Brugia malayi Protein kinase domain containing protein 0.001 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0155
Loa Loa (eye worm) blistered cuticle protein 3 0.0514 0.3905 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0018 0.0496
Brugia malayi hypothetical protein 0.0011 0.0035 0.0078
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0205 0.0446
Brugia malayi PAN domain containing protein 0.0028 0.0166 0.0413
Echinococcus granulosus survival motor neuron protein 1 0.0171 0.1266 0.2808
Brugia malayi MH1 domain containing protein 0.0007 0.0006 0.0004
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0078
Echinococcus multilocularis neurogenic locus notch protein 0.0166 0.1228 0.1224
Loa Loa (eye worm) hypothetical protein 0.0166 0.1228 0.3137
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0023 0.0736
Echinococcus multilocularis Smad4 0.0013 0.0051 0.0046
Echinococcus multilocularis lamin 0.0086 0.0611 0.0607
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0055 0.0373 0.0945
Loa Loa (eye worm) hypothetical protein 0.0514 0.3905 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0067 0.0464 0.046
Loa Loa (eye worm) animal heme peroxidase 0.0514 0.3905 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0065 0.0155

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.13 uM Tested for inhibition of EGF(epidermal growth factor) to C3H10T1/2 cells. ChEMBL. 10715158
ED50 (functional) = 0.13 uM Tested for inhibition of EGF(epidermal growth factor) to C3H10T1/2 cells. ChEMBL. 10715158
ED50 (binding) = 0.34 uM Activation of PK-C-alpha-dependent peptide phosphorylation ChEMBL. 10715158
ED50 (binding) = 0.34 uM Activation of PK-C-alpha-dependent peptide phosphorylation ChEMBL. 10715158
GI50 (functional) -5.486 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.435 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.134 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.002 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.944 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.926 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.906 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.873 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.796 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
Ki (binding) = 7.3 nM Binding Affinity against protein kinase C alpha ChEMBL. 10715158
Ki (binding) = 7.3 nM Binding Affinity against protein kinase C alpha ChEMBL. 10715158

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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