Detailed information for compound 315572

Basic information

Technical information
  • TDR Targets ID: 315572
  • Name: (2S)-2-[[(2R)-2-(4-carbamimidoylanilino)-2-(3 -methoxy-4-phenylmethoxyphenyl)acetyl]amino]- 2-phenylacetic acid
  • MW: 538.594 | Formula: C31H30N4O5
  • H donors: 4 H acceptors: 3 LogP: 4.64 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1OCc1ccccc1)[C@H](C(=O)N[C@@H](c1ccccc1)C(=O)O)Nc1ccc(cc1)C(=N)N
  • InChi: 1S/C31H30N4O5/c1-39-26-18-23(14-17-25(26)40-19-20-8-4-2-5-9-20)27(34-24-15-12-22(13-16-24)29(32)33)30(36)35-28(31(37)38)21-10-6-3-7-11-21/h2-18,27-28,34H,19H2,1H3,(H3,32,33)(H,35,36)(H,37,38)/t27-,28+/m1/s1
  • InChiKey: WGEGXJPYFSZDMU-IZLXSDGUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[[(2R)-2-(4-benzyloxy-3-methoxy-phenyl)-2-(4-carbamimidoylanilino)acetyl]amino]-2-phenyl-acetic acid
  • (2S)-2-[[(2R)-2-(4-benzyloxy-3-methoxyphenyl)-2-(4-carbamimidoylanilino)-1-oxoethyl]amino]-2-phenylacetic acid
  • (2S)-2-[[(2R)-2-[(4-carbamimidoylphenyl)amino]-2-(3-methoxy-4-phenylmethoxy-phenyl)ethanoyl]amino]-2-phenyl-ethanoic acid
  • (2S)-2-[[(2R)-2-(4-amidinoanilino)-2-(4-benzoxy-3-methoxy-phenyl)acetyl]amino]-2-phenyl-acetic acid
  • (2S)-2-[[(2R)-2-[(4-carbamimidoylphenyl)amino]-2-[3-methoxy-4-(phenylmethoxy)phenyl]acetyl]amino]-2-phenylacetic acid
  • (2S)-2-[[(2R)-2-[(4-carbamimidoylphenyl)amino]-2-[3-methoxy-4-(phenylmethoxy)phenyl]acetyl]amino]-2-phenyl-acetic acid
  • (2S)-2-[[(2R)-2-[(4-carbamimidoylphenyl)amino]-2-[3-methoxy-4-(phenylmethoxy)phenyl]-1-oxoethyl]amino]-2-phenylacetic acid
  • (2S)-2-[[(2R)-2-[(4-amidinophenyl)amino]-2-[4-(benzyloxy)-3-methoxy-phenyl]acetyl]amino]-2-phenyl-acetic acid
  • (2S)-2-[[(2R)-2-[(4-carbamimidoylphenyl)amino]-2-[3-methoxy-4-(phenylmethoxy)phenyl]ethanoyl]amino]-2-phenyl-ethanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) Starlite/ChEMBL References
Homo sapiens protease, serine, 1 (trypsin 1) Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Echinococcus granulosus glycoprotein Antigen 5 coagulation factor VII (serum prothrombin conversion accelerator) 466 aa 384 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0116 0.0147
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0224 0.053
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.1712 0.171
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Echinococcus multilocularis geminin 0.0165 0.3998 0.3996
Echinococcus granulosus lamin dm0 0.0026 0.0428 0.0426
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0017 0.0192 0.0084
Echinococcus granulosus cpg binding protein 0.003 0.0513 0.0511
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.1673 0.4468
Loa Loa (eye worm) hypothetical protein 0.0123 0.2931 0.3804
Echinococcus multilocularis fibropellin Ia 0.0014 0.0109 0.0106
Treponema pallidum uridine phosphorylase (udp) 0.0026 0.0413 0.1616
Brugia malayi MTAP 0.0026 0.0413 0.0728
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0017 0.0192 0.0189
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0147 0.3542 1
Onchocerca volvulus 0.0106 0.2492 0.4297
Schistosoma mansoni ap endonuclease 0.0018 0.0224 0.0116
Mycobacterium ulcerans hypothetical protein 0.002 0.0258 0.034
Echinococcus multilocularis transmembrane protease serine 3 0.0017 0.0192 0.0189
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0224 0.0221
Echinococcus granulosus laminin 0.0016 0.0168 0.0165
Echinococcus granulosus fibropellin Ia 0.0014 0.0109 0.0106
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.03 0.0406
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0105 0.2445 0.8206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Loa Loa (eye worm) hypothetical protein 0.0159 0.3841 0.4987
Schistosoma mansoni egf-like domain protein 0.0016 0.0168 0.0059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Echinococcus multilocularis protein jagged 2 0.0014 0.0109 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Onchocerca volvulus 0.0035 0.0655 0.1038
Onchocerca volvulus 0.0017 0.0192 0.0217
Echinococcus multilocularis uridine phosphorylase 1 0.0026 0.0413 0.0411
Giardia lamblia UPL-1 0.0026 0.0413 0.1073
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0026 0.0413 0.09
Loa Loa (eye worm) hypothetical protein 0.0017 0.0179 0.0229
Echinococcus granulosus peptidase Clp S14 family 0.005 0.1037 0.1034
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2756 0.9328
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0224 0.0392
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.1712 0.171
Onchocerca volvulus 0.0014 0.0109 0.007
Echinococcus granulosus protein jagged 1 0.0014 0.0109 0.0106
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.03 0.0543
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1712 0.557
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0287 0.044
Onchocerca volvulus Slit protein homolog 0.0014 0.0109 0.007
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0017 0.0192 0.0189
Mycobacterium tuberculosis Probable reductase 0.0105 0.2455 0.8243
Toxoplasma gondii phosphorylase family protein 0.0026 0.0413 0.0886
Loa Loa (eye worm) hypothetical protein 0.0016 0.0168 0.0215
Brugia malayi Trypsin family protein 0.0017 0.0192 0.0338
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0069 0.0067
Brugia malayi Fibulin-1 precursor 0.0016 0.0168 0.0296
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0428 0.0915
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Loa Loa (eye worm) RecQ helicase 0.0021 0.0287 0.037
Schistosoma mansoni cpg binding protein 0.0028 0.0472 0.0367
Loa Loa (eye worm) thymidylate synthase 0.0105 0.2445 0.3172
Echinococcus multilocularis musashi 0.0026 0.0428 0.0426
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0413 0.0308
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0258 0.0334
Loa Loa (eye worm) hypothetical protein 0.0076 0.1712 0.222
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0168 0.0296
Onchocerca volvulus 0.0026 0.0428 0.0637
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1712 0.4668
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0124 0.2943 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Schistosoma mansoni lamin 0.0026 0.0428 0.0323
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0413 1
Mycobacterium ulcerans thymidylate synthase 0.0105 0.2445 0.8206
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.1712 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0168 0.0215
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0168 0.0215
Brugia malayi Trypsin family protein 0.0123 0.2931 0.5163
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0163 0.0356
Echinococcus granulosus neural cadherin 0.0014 0.0109 0.0106
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0163 0.0157
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0472 0.061
Brugia malayi dihydrofolate reductase family protein 0.0043 0.085 0.1498
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Onchocerca volvulus Putative cubilin 0.0014 0.0109 0.007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0079 0.0099
Schistosoma mansoni hypothetical protein 0.0398 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0331
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Leishmania major methylthioadenosine phosphorylase, putative 0.0026 0.0413 0.1071
Schistosoma mansoni lamin 0.0026 0.0428 0.0323
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0168 0.0171
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Trypanosoma brucei uridine phosphorylase 0.0026 0.0413 0.1071
Trichomonas vaginalis conserved hypothetical protein 0.005 0.1033 0.1757
Echinococcus granulosus thymidylate synthase 0.0105 0.2445 0.2443
Onchocerca volvulus 0.0105 0.2445 0.4214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0192 0.0246
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0163 0.0356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0662
Echinococcus multilocularis neurogenic locus notch protein 4 0.0014 0.0109 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0937 0.2566
Brugia malayi hypothetical protein 0.0159 0.3841 0.6767
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Echinococcus multilocularis cpg binding protein 0.003 0.0513 0.0511
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.3525 0.4575
Echinococcus granulosus notch 0.0014 0.0109 0.0106
Brugia malayi Uncoordinated protein 44 0.0014 0.0113 0.0199
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0224 0.0328
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.085 0.2472
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0163 0.0356
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0069 0.0055
Mycobacterium tuberculosis Hypothetical protein 0.0026 0.0413 0.09
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.2455 0.8243
Onchocerca volvulus Neurogenic locus notch homolog 0.0014 0.0112 0.0076
Onchocerca volvulus 0.0014 0.0109 0.007
Toxoplasma gondii Purine nucleoside phosphorylase 0.0026 0.0413 0.0886
Echinococcus multilocularis lamin 0.0026 0.0428 0.0426
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0115 0.0145
Echinococcus granulosus neurogenic locus notch protein 0.0014 0.0109 0.0106
Plasmodium vivax glutathione reductase, putative 0.0046 0.0937 0.2401
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0124 0.2943 0.5099
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0124 0.2943 0.5185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0192 0.0246
Onchocerca volvulus 0.0123 0.2931 0.5077
Loa Loa (eye worm) hypothetical protein 0.0026 0.0428 0.0553
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0069 0.0087
Schistosoma mansoni cpg binding protein 0.003 0.0513 0.0409
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0662
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1712 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.03 0.0387
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0222 0.0175
Onchocerca volvulus 0.0017 0.0192 0.0217
Echinococcus granulosus lamin 0.0026 0.0428 0.0426
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0516 0.0514
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0413 0.0662
Schistosoma mansoni uridine phosphorylase 0.0026 0.0413 0.0308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Toxoplasma gondii exonuclease III APE 0.0018 0.0224 0.0334
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0069 0.0089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0413 0.09
Echinococcus multilocularis purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0473 0.047
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0413 0.1071
Echinococcus multilocularis fat cadherin tumor suppressor 0.0014 0.0109 0.0106
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4982 0.6469
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0258 0.034
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0428 0.1247
Echinococcus multilocularis neural cadherin 0.0014 0.0109 0.0106
Brugia malayi PAS domain containing protein 0.0047 0.0971 0.1711
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0416 0.0537
Brugia malayi EGF-like domain containing protein 0.0014 0.0109 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.03 0.0748
Echinococcus multilocularis dnaJ subfamily B 0.0398 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0224 0.0287
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.03 0.0387
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0079 0.0076
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.085 0.2472
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0163 0.0191
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0873
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0069 0.0089
Brugia malayi hypothetical protein 0.023 0.5677 1
Echinococcus granulosus single minded 2 0.0035 0.0655 0.0652
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0163 0.0571
Echinococcus granulosus Ankyrin 0.0014 0.0116 0.0113
Brugia malayi Delta serrate ligand family protein 0.0014 0.0109 0.0192
Schistosoma mansoni purine nucleoside phosphorylase 0.0124 0.2943 0.2866
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0147 0.3542 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.1598 0.1595
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0014 0.0109 0.007
Echinococcus granulosus neurogenic locus notch protein 0.0014 0.0109 0.0106
Schistosoma mansoni survival motor neuron protein 0.0047 0.0961 0.0861
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0413 0.1073
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0516 0.0514
Brugia malayi Pre-SET motif family protein 0.003 0.0516 0.0909
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0069 0.0089
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0069 0.0055
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0428 0.1708
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0163 0.0356
Brugia malayi hypothetical protein 0.0118 0.2802 0.4936
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0113 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0113 0.0143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0224 0.0392
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0224 0.018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0163 0.0356
Mycobacterium ulcerans epimerase 0.002 0.0258 0.034
Loa Loa (eye worm) Notch2 0.0014 0.0109 0.0138
Toxoplasma gondii hypothetical protein 0.0026 0.0428 0.0928
Echinococcus granulosus protein jagged 1 0.0014 0.0109 0.0106
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0662
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Leishmania major hypothetical protein, conserved 0.0021 0.03 0.0748
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0428 0.0553
Loa Loa (eye worm) hypothetical protein 0.0017 0.0192 0.0246
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Brugia malayi hypothetical protein 0.005 0.1033 0.182
Brugia malayi EGF-like domain containing protein 0.0014 0.0109 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Leishmania major protein kinase, putative 0.0012 0.0069 0.0089
Echinococcus multilocularis protein jagged 1 0.0014 0.0109 0.0106
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0168 0.0215
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0163 0.0221
Brugia malayi Cadherin domain containing protein 0.0014 0.0109 0.0192
Schistosoma mansoni purine nucleoside phosphorylase 0.0124 0.2943 0.2866
Echinococcus granulosus methylthioadenosine phosphorylase 0.0026 0.0413 0.0411
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0224 0.0394
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1712 0.557
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1712 1
Echinococcus granulosus transmembrane protease serine 3 0.0017 0.0192 0.0189
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0026 0.0413 0.09
Schistosoma mansoni cpg binding protein 0.003 0.0513 0.0409
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0163 0.0143
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0098 0.2283 0.2281
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0069 0.0089
Echinococcus multilocularis protein jagged 1 0.0014 0.0109 0.0106
Onchocerca volvulus 0.0017 0.0192 0.0217
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0163 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0168 0.0215
Echinococcus multilocularis glycoprotein Antigen 5 0.0017 0.0192 0.0189
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0124 0.2943 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0069 0.0055
Schistosoma mansoni dihydrofolate reductase 0.0043 0.085 0.0749
Brugia malayi hypoxia-induced factor 1 0.0147 0.3525 0.6209
Onchocerca volvulus 0.0017 0.0192 0.0217
Echinococcus granulosus protein jagged 2 0.0014 0.0109 0.0106
Schistosoma mansoni netrin receptor unc5 0.0014 0.0113 0.0004
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0163 0.016
Brugia malayi Trypsin family protein 0.0017 0.0192 0.0338
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.085 0.2717
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Echinococcus granulosus Tolloid protein 1 0.0016 0.0168 0.0165
Echinococcus granulosus geminin 0.0165 0.3998 0.3996
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0017 0.0192 0.0084
Onchocerca volvulus 0.0231 0.5706 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1712 0.4583
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.1712 0.162
Schistosoma mansoni hypothetical protein 0.0021 0.03 0.0193
Schistosoma mansoni single-minded 0.0047 0.0971 0.0872
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Schistosoma mansoni hypothetical protein 0.0047 0.0961 0.0861
Brugia malayi Death domain containing protein 0.0014 0.0113 0.0199
Brugia malayi Kringle domain containing protein 0.0021 0.03 0.0529
Brugia malayi EGF-like domain containing protein 0.0014 0.0109 0.0192
Loa Loa (eye worm) hypothetical protein 0.0309 0.7701 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1143 0.3012
Echinococcus multilocularis purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.03 0.0298
Brugia malayi Cadherin domain containing protein 0.0014 0.0109 0.0192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0937 0.0935
Treponema pallidum pfs protein (pfs) 0.0026 0.0413 0.1616
Echinococcus multilocularis neurogenic locus protein delta 0.0014 0.0109 0.0106
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0026 0.0413 0.0411
Echinococcus multilocularis lamin dm0 0.0026 0.0428 0.0426
Echinococcus multilocularis purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0113 0.0004
Mycobacterium leprae conserved hypothetical protein 0.002 0.0258 0.0655
Brugia malayi EGF-like domain containing protein 0.0014 0.0109 0.0192
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0069 0.0055
Echinococcus granulosus intermediate filament protein 0.0026 0.0428 0.0426
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0163 0.0221
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0163 0.0356
Loa Loa (eye worm) hypothetical protein 0.023 0.5677 0.7371
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0937 0.1214
Echinococcus multilocularis neurogenic locus notch protein 0.0014 0.0109 0.0106
Onchocerca volvulus 0.0047 0.0961 0.1582
Loa Loa (eye worm) hypothetical protein 0.0017 0.0192 0.0246
Plasmodium falciparum glutathione reductase 0.0046 0.0937 0.2291
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0428 0.0755
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0069 0.0055
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0413 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.5703 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0662
Brugia malayi Probable ClpP-like protease 0.0076 0.1712 0.3016
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0069 0.0055
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0026 0.0413 0.09
Onchocerca volvulus Arrow homolog 0.0016 0.0168 0.0175
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0113 0.0143
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0017 0.0192 0.0084
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0163 0.0288
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0105 0.2445 0.8264
Mycobacterium leprae probable uridine phosphorylase 0.0026 0.0413 0.1197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Loa Loa (eye worm) hypothetical protein 0.0098 0.2283 0.2962
Schistosoma mansoni hypothetical protein 0.0017 0.0192 0.0084
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0163 0.0356
Echinococcus multilocularis laminin 0.0016 0.0168 0.0165
Echinococcus granulosus survival motor neuron protein 1 0.023 0.5677 0.5676
Echinococcus granulosus slit 2 protein 0.0014 0.0109 0.0106
Schistosoma mansoni uridine phosphorylase 0.0026 0.0413 0.0308
Loa Loa (eye worm) hypothetical protein 0.0017 0.0192 0.0246
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.2455 0.8243
Loa Loa (eye worm) hypothetical protein 0.0075 0.1673 0.217
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.1037 0.1034
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0224 0.4947
Toxoplasma gondii endonuclease IV APN 0.0075 0.1673 0.4555
Echinococcus multilocularis purine nucleoside phosphorylase 0.0098 0.2283 0.2281
Echinococcus multilocularis Mastin 0.0017 0.0192 0.0189
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0109 0.0192
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.5677 0.5676
Echinococcus granulosus glycoprotein Antigen 5 0.0017 0.0192 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0516 0.0412
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0113 0.011
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0026 0.0413 0.1616
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0069 0.0067
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0516 0.1186
Onchocerca volvulus 0.0014 0.0109 0.007
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0168 0.0171
Mycobacterium ulcerans endonuclease IV 0.0075 0.1673 0.543
Echinococcus multilocularis purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.1712 0.4661
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0026 0.0413 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0069 0.0055
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0224 0.0405
Onchocerca volvulus 0.003 0.0516 0.0793
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0175 0.0066
Schistosoma mansoni ap endonuclease 0.0018 0.0224 0.0116
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.085 0.1101
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0413 0.1071
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Echinococcus multilocularis thymidylate synthase 0.0105 0.2445 0.2443
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0124 0.2943 1
Leishmania major nucleoside phosphorylase-like protein 0.0026 0.0413 0.1071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0516 0.0412
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0147 0.3542 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.1598 0.1595
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0069 0.0067
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0069 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0413 0.0662
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123 0.2931 0.2853
Leishmania major protein kinase, putative 0.0012 0.0069 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0069 0.0055
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.1037 0.3366
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0224 0.032
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0655 0.0652
Brugia malayi notch-like transmembrane receptor 0.0014 0.0109 0.0192
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0017 0.0192 0.0084
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.085 0.4755
Onchocerca volvulus 0.0026 0.0428 0.0637
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0258 0.034
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0168 0.0296
Onchocerca volvulus 0.0014 0.0109 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0168 0.0059
Toxoplasma gondii phosphorylase family protein 0.0026 0.0413 0.0886
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0168 0.0215
Loa Loa (eye worm) notch protein 0.0014 0.0109 0.0138
Brugia malayi Muscle positioning protein 4 0.0014 0.0109 0.0192
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0113 0.0199
Echinococcus multilocularis purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0017 0.0192 0.0189
Echinococcus granulosus neurogenic locus protein delta 0.0014 0.0109 0.0106
Echinococcus granulosus bloom syndrome protein 0.0021 0.0287 0.0285
Brugia malayi intermediate filament protein 0.0026 0.0428 0.0755
Chlamydia trachomatis AMP nucleosidase 0.0026 0.0413 0.2094
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0287 0.044
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.03 0.0298
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0224 0.0221
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0413 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0662
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0017 0.0192 0.0084
Onchocerca volvulus 0.0021 0.03 0.041
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Brugia malayi EGF-like domain containing protein 0.0014 0.0109 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0083
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0017 0.0192 0.0189
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.2455 0.8243
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0069 0.0067
Toxoplasma gondii thioredoxin reductase 0.0046 0.0937 0.2412
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1712 1
Schistosoma mansoni hypothetical protein 0.0165 0.3998 0.3932
Loa Loa (eye worm) uridine phosphorylase 0.0026 0.0413 0.0533
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0287 0.0506
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0413 1
Onchocerca volvulus 0.0017 0.0192 0.0217
Brugia malayi CXXC zinc finger family protein 0.0028 0.0472 0.0832
Mycobacterium ulcerans hypothetical protein 0.0017 0.0192 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0937 0.0935
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0516 0.0412
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1712 0.4668
Onchocerca volvulus 0.0014 0.0109 0.007
Brugia malayi GCC2 and GCC3 family protein 0.0014 0.0109 0.0192
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.1673 0.2947
Echinococcus granulosus dihydrofolate reductase 0.0043 0.085 0.0848
Schistosoma mansoni hypothetical protein 0.0014 0.0113 0.0004
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0258 0.0454
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0961 0.1693
Echinococcus multilocularis Ankyrin 0.0014 0.0116 0.0113
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0113 0.011
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0069 0.0089
Toxoplasma gondii kringle domain-containing protein 0.0021 0.03 0.0557
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0413 0.1071
Brugia malayi Pre-SET motif family protein 0.0203 0.4982 0.8777
Plasmodium vivax SET domain protein, putative 0.003 0.0516 0.1173
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0105 0.2445 0.2361
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0516 0.0514
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0069 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0516 0.0412
Trypanosoma brucei trypanothione reductase 0.0046 0.0937 0.2566
Leishmania major trypanothione reductase 0.0046 0.0937 0.2566
Echinococcus granulosus neurogenic locus notch protein 4 0.0014 0.0109 0.0106
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0224 0.0218
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0163 0.0356
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0428 0.0553
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0163 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0069 0.0055
Mycobacterium tuberculosis Hypothetical protein 0.005 0.1033 0.313
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0224 0.053
Schistosoma mansoni notch 0.0014 0.0112 0.0003
Echinococcus multilocularis purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0109 0.0192
Loa Loa (eye worm) hypothetical protein 0.0016 0.0168 0.0215
Brugia malayi Protein kinase domain containing protein 0.0014 0.0113 0.0199
Brugia malayi Dihydrofolate reductase 0.0043 0.085 0.1498
Loa Loa (eye worm) hypothetical protein 0.0123 0.2931 0.3804
Brugia malayi Thioredoxin reductase 0.0046 0.0937 0.1651
Brugia malayi glutathione reductase 0.0046 0.0937 0.1651
Schistosoma mansoni intermediate filament proteins 0.0026 0.0428 0.0323
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2756 0.9328
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2756 0.935
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0937 0.2784
Loa Loa (eye worm) hypothetical protein 0.0016 0.0168 0.0215
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0026 0.0413 0.0533
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0662
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0163 0.0356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Loa Loa (eye worm) hypothetical protein 0.003 0.0516 0.0667
Echinococcus multilocularis neurogenic locus notch protein 0.0014 0.0109 0.0106
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0026 0.0413 0.1073
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0026 0.0413 0.0662
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Echinococcus granulosus protein jagged 2 0.0014 0.0109 0.0106
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0287 0.0285
Echinococcus multilocularis notch 0.0014 0.0109 0.0106
Echinococcus multilocularis enteropeptidase 0.0017 0.0192 0.0189
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.3542 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0224 0.053
Echinococcus granulosus death domain containing protein 0.0014 0.0113 0.011
Echinococcus multilocularis fibrillin 1 0.0016 0.0168 0.0165
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0116 0.0007
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0069 0.0055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0224 0.0218
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0109 0.0192
Plasmodium falciparum purine nucleoside phosphorylase 0.0026 0.0413 0.074
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0224 0.0328
Onchocerca volvulus 0.0028 0.0472 0.0715
Schistosoma mansoni cercarial elastase (S01 family) 0.0017 0.0192 0.0084
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0428 0.0783
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0115 0.0202
Loa Loa (eye worm) glutathione reductase 0.0046 0.0937 0.1214
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.1037 0.3143
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0113 0.011
Echinococcus granulosus purine nucleoside phosphorylase 0.0124 0.2943 0.2941
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0163 0.016
Brugia malayi Protein kinase domain containing protein 0.0021 0.03 0.0529
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0655 0.1768
Brugia malayi Trypsin-like protease protein 5 0.0017 0.0192 0.0338
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0971 0.0872
Schistosoma mansoni hypothetical protein 0.0017 0.0192 0.0084
Brugia malayi EGF-like domain containing protein 0.0014 0.0109 0.0192
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.1037 0.3143
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0017 0.0192 0.0338
Echinococcus granulosus uridine phosphorylase 1 0.0026 0.0413 0.0411
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.1673 0.543
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0113 0.0077
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0147 0.3542 1
Echinococcus granulosus Mastin 0.0017 0.0192 0.0189
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0026 0.0413 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0163 0.0356
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0413 0.0308
Echinococcus granulosus enteropeptidase 0.0017 0.0192 0.0189
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0069 0.0055
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0138
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0014 0.0109 0.0192
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0124 0.2943 0.5129
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.2455 0.8243
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.3542 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0937 0.2401
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.1033 0.284
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0026 0.0413 0.1071
Schistosoma mansoni hypothetical protein 0.0165 0.3998 0.3932
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0026 0.0413 0.1071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0224 0.053
Brugia malayi thymidylate synthase 0.0105 0.2445 0.4306
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2756 0.9328
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0079 0.0076
Brugia malayi Trypsin family protein 0.0017 0.0192 0.0338
Schistosoma mansoni methylthioadenosine phosphorylase 0.0026 0.0413 0.0308
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0163 0.0143
Chlamydia trachomatis endonuclease IV 0.0075 0.1673 0.9763
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0083
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.1673 0.4547
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0054 0.0096
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.1712 0.5715
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.1673 0.5579
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0026 0.0413 0.1071
Brugia malayi EGF-like domain containing protein 0.0014 0.0109 0.0192
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0123 0.2931 0.2853
Brugia malayi uridine phosphorylase family protein 0.0026 0.0413 0.0728
Echinococcus multilocularis purine nucleoside phosphorylase 0.0098 0.2283 0.2281
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.2455 0.8243
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0168 0.0165
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0017 0.0192 0.0084
Entamoeba histolytica hypothetical protein 0.0026 0.0413 1
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.085 0.0848
Plasmodium falciparum thioredoxin reductase 0.0046 0.0937 0.2291
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0054 0.0096
Brugia malayi hypothetical protein 0.0017 0.0192 0.0338
Echinococcus granulosus delta-like protein 1 0.0014 0.0109 0.0106
Echinococcus multilocularis slit 2 protein 0.0014 0.0109 0.0106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1306 0.121
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.2455 0.83
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0655 0.1153
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0124 0.2943 1
Echinococcus multilocularis neurogenic locus protein delta 0.0014 0.0109 0.0106
Loa Loa (eye worm) trypsin family protein 0.0017 0.0192 0.0246
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0087

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.004 uM The value of binding constant measured against coagulation factor VII ChEMBL. 15664864
Ki (binding) = 0.004 uM The value of binding constant measured against coagulation factor VII ChEMBL. 15664864
Ki (binding) = 0.035 uM The value of binding constant measured against human Thrombin ChEMBL. 15664864
Ki (binding) = 0.035 uM The value of binding constant measured against human Thrombin ChEMBL. 15664864
Ki (binding) = 0.04 uM The value of binding constant measured against human trypsin ChEMBL. 15664864
Ki (binding) = 0.04 uM The value of binding constant measured against human trypsin ChEMBL. 15664864
Ki (binding) = 8 uM The value of binding constant measured against coagulation factor X (factor Xa) ChEMBL. 15664864
Ki (binding) = 8 uM The value of binding constant measured against coagulation factor X (factor Xa) ChEMBL. 15664864
Ratio (binding) = 8.8 uM The ratio of binding constants of Thrombin to coagulation factor VII ChEMBL. 15664864

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.