Detailed information for compound 339073

Basic information

Technical information
  • TDR Targets ID: 339073
  • Name: 2-[4-(5-bromo-6-hydroxynaphthalen-1-yl)-3,5-d ichloroanilino]acetic acid
  • MW: 441.103 | Formula: C18H12BrCl2NO3
  • H donors: 3 H acceptors: 3 LogP: 5.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CNc1cc(Cl)c(c(c1)Cl)c1cccc2c1ccc(c2Br)O
  • InChi: 1S/C18H12BrCl2NO3/c19-18-12-3-1-2-11(10(12)4-5-15(18)23)17-13(20)6-9(7-14(17)21)22-8-16(24)25/h1-7,22-23H,8H2,(H,24,25)
  • InChiKey: SWLMBQBHXJFLIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(5-bromo-6-hydroxy-1-naphthyl)-3,5-dichloro-anilino]acetic acid
  • 2-[4-(5-bromo-6-hydroxy-1-naphthyl)-3,5-dichloroanilino]acetic acid
  • 2-[[4-(5-bromo-6-hydroxy-naphthalen-1-yl)-3,5-dichloro-phenyl]amino]ethanoic acid
  • 2-[[4-(5-bromo-6-hydroxynaphthalen-1-yl)-3,5-dichlorophenyl]amino]acetic acid
  • 2-[[4-(5-bromo-6-hydroxy-1-naphthyl)-3,5-dichloro-phenyl]amino]acetic acid
  • 2-[[4-(5-bromo-6-hydroxy-1-naphthyl)-3,5-dichlorophenyl]amino]acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL References
Homo sapiens thyroid hormone receptor, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_156853 All targets in OG5_156853
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, alpha 451 aa 372 aa 25.3 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0108 0.1407
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0108 0.1252
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0024 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0281 0.1684 0.1684
Brugia malayi RNA, U transporter 1 0.008 0.0436 0.143
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.0521
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.005 0.0087
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0024 0.0177
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0497
Echinococcus granulosus survival motor neuron protein 1 0.0472 0.2872 0.3378
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0497
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0497
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0172 0.1006 0.8554
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0009 0.0011
Onchocerca volvulus 0.0012 0.0012 0.0013
Echinococcus multilocularis muscleblind protein 0.0298 0.1791 0.1791
Loa Loa (eye worm) endoplasmin 0.0027 0.0108 0.0329
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Plasmodium falciparum heat shock protein 90 0.0027 0.0108 0.2374
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.005 0.0555
Onchocerca volvulus 0.0014 0.0024 0.0081
Onchocerca volvulus 0.0012 0.0012 0.0013
Onchocerca volvulus 0.0012 0.0012 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0323 0.0379
Entamoeba histolytica hypothetical protein 0.0023 0.008 0.0688
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0108 0.0281
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0177
Toxoplasma gondii patched family protein 0.0012 0.0012 0.01
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.1159 0.1159
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0232 0.3115
Schistosoma mansoni ran 0.0021 0.0067 0.0078
Brugia malayi Cytochrome P450 family protein 0.0018 0.005 0.0135
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.009 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.005 0.0385
Loa Loa (eye worm) oxidoreductase 0.0014 0.0024 0.0049
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0108 0.0329
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0067 0.0078
Trichomonas vaginalis DNA topoisomerase II, putative 0.0027 0.0108 0.2329
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0113 0.0113
Schistosoma mansoni cpg binding protein 0.0031 0.013 0.0153
Echinococcus granulosus importin subunit beta 1 0.0028 0.0113 0.0133
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0027 0.0108 0.3334
Schistosoma mansoni microtubule-associated protein tau 0.1376 0.8501 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.012 0.037
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0108 0.0281
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0108 0.2374
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.3313
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.009 0.0105
Echinococcus multilocularis cpg binding protein 0.0031 0.013 0.013
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0108 0.1252
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0145 0.1965
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0462 0.0543
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0491 0.2992 0.352
Leishmania major GTP-binding protein, putative 0.0021 0.0067 0.0143
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0108 0.2374
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0038 0.0177 0.0516
Brugia malayi hypothetical protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0016 0.0035 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.005 0.0555
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0462 1
Brugia malayi nuclear receptor RXR 0.0013 0.0018 0.0029
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0347
Mycobacterium ulcerans 5'-3' exonuclease 0.0038 0.0177 0.2294
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.005 0.0385
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0232 0.3115
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0232 0.3115
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Loa Loa (eye worm) hypothetical protein 0.0084 0.0462 0.1517
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Toxoplasma gondii hypothetical protein 0.0012 0.0012 0.01
Loa Loa (eye worm) hypothetical protein 0.0196 0.1159 0.3855
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.009 0.0269
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0145 0.1965
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0384 0.0452
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.005 0.0385
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Brugia malayi Cytochrome P450 family protein 0.0027 0.0105 0.0321
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.009 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0108 0.2374
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.009 0.0269
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0108 0.0281
Onchocerca volvulus Protein patched homolog 0.0012 0.0012 0.0013
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.005 0.0555
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.005 0.0385
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0009 0.0009
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0108 0.1252
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0049
Schistosoma mansoni nuclear hormone receptor 0.0024 0.009 0.0105
Onchocerca volvulus 0.0096 0.0536 0.2902
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0232 0.8293
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.009 0.0442
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0108 0.2329
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0177
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0108 0.0928
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0038 0.0177 0.3908
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.009 0.0105
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.005 0.0385
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.0035 0.0038
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0024 0.0177
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0691 0.0813
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0029
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0232 0.8293
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Echinococcus multilocularis heat shock protein 90 0.0027 0.0108 0.0108
Brugia malayi kinase, mitochondrial precursor 0.0491 0.2992 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0108 0.2374
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0108 0.0127
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0176 0.1036 0.1218
Echinococcus multilocularis 0.0018 0.005 0.005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0049
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0018 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0145 0.1965
Trichomonas vaginalis endoplasmin, putative 0.0027 0.0108 0.2329
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0497
Loa Loa (eye worm) hypothetical protein 0.0298 0.1791 0.5974
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0453 0.1446
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.0143
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0157 0.2142
Brugia malayi Telomerase reverse transcriptase 0.022 0.1309 0.4358
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.009 0.0269
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.005 0.0555
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0038 0.0177 0.3908
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0108 0.0281
Brugia malayi hypothetical protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.009 0.0269
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0108 0.0281
Leishmania major cytochrome p450-like protein 0.0027 0.0105 0.0273
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0108 0.0281
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0108 0.1252
Brugia malayi Endoplasmin precursor 0.0027 0.0108 0.0329
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0108 0.1407
Brugia malayi cytochrome P450 0.0018 0.005 0.0135
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.005 0.0385
Brugia malayi nuclear receptor NHR-88 0.0024 0.009 0.0269
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.1808 0.603
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0232 0.3115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0029
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.005 0.0385
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0054 0.0275 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0027 0.0108 0.2329
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0027 0.0108 0.3334
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0301 0.181 0.6036
Schistosoma mansoni coup transcription factor 0.0024 0.009 0.0105
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0108 0.1407
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0303 0.1825 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.009 0.0269
Brugia malayi Patched protein homolog 1 0.0012 0.0012 0.0008
Brugia malayi Myosin head containing protein 0.0012 0.0012 0.0008
Plasmodium vivax telomerase reverse transcriptase, putative 0.0083 0.0453 1
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0016 0.0035 0.0304
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1006 0.3307
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Toxoplasma gondii patched family protein 0.0012 0.0012 0.01
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0691 0.0691
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0232 0.0746
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0113 0.0299
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0012 0.0259
Echinococcus multilocularis protein patched 0.0084 0.0462 0.0462
Echinococcus multilocularis thyroid hormone receptor alpha 0.0176 0.1036 0.1036
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0016 0.0035 0.0038
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Trichomonas vaginalis ran, putative 0.0021 0.0067 0.1442
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0691 1
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0108 0.1252
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.005 0.0555
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0108 0.2374
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.1159 0.1364
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.005 0.0385
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.3313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.009 0.0269
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Giardia lamblia Telomerase catalytic subunit 0.0083 0.0453 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.009 0.0105
Mycobacterium leprae Probable two-component sensor kinase 0.0027 0.0108 0.3334
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0087
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0108 0.0541
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0323 0.0379
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0199 0.1175 1
Brugia malayi protein C24B5.3 0.0012 0.0012 0.0008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.008 0.0188
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0232 0.3115
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0384 0.0452
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0108 0.1407
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0038 0.0177 0.0516
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0232 0.2
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0108 0.0281
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0105 0.0273
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0016 0.0035 0.03
Plasmodium falciparum plastid replication-repair enzyme 0.0016 0.0035 0.0777
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0008
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0024 0.0024
Schistosoma mansoni nuclear receptor 0.0012 0.0009 0.0011
Brugia malayi hypothetical protein 0.0013 0.0018 0.0029
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0108 0.2329
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0008
Mycobacterium ulcerans hypothetical protein 0.0047 0.0232 0.3115
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0108 0.2374
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0491 0.2992 0.2992
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0232 0.0746
Onchocerca volvulus 0.0012 0.0012 0.0013
Schistosoma mansoni survival motor neuron protein 0.0096 0.0536 0.0631
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0108 0.2374
Trypanosoma brucei developmentally regulated phosphoprotein 0.0491 0.2992 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.008 0.0188
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0038 0.0177 0.243
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0024 0.053
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0024 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.009 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0232 0.07
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0108 0.0281
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0108 0.0541
Loa Loa (eye worm) hypothetical protein 0.0298 0.1791 0.5974
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0108 0.0281
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0108 0.0329
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0009 0.0011
Leishmania major developmentally regulated phosphoprotein-like protein 0.0491 0.2992 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0108 0.1407
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0462 0.0543
Schistosoma mansoni heat shock protein 0.0027 0.0108 0.0127
Leishmania major cytochrome p450-like protein 0.0018 0.005 0.0087
Schistosoma mansoni cpg binding protein 0.0031 0.013 0.0153
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.3313
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Trichomonas vaginalis sensor histidine kinase, putative 0.0027 0.0108 0.2329
Trichomonas vaginalis DNA polymerase I, putative 0.0016 0.0035 0.0762
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.005 0.0555
Schistosoma mansoni cytochrome P450 0.0018 0.005 0.0058
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0067 0.0567
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.0521
Brugia malayi ecdysteroid receptor 0.0024 0.009 0.0269
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.005 0.0385
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0108 0.0541
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.005 0.0385
Loa Loa (eye worm) twinkle helicase 0.0012 0.001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0027 0.0108 0.1407
Onchocerca volvulus 0.0029 0.012 0.0607
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.005 0.0385
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.009 0.0105
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0108 0.1252
Brugia malayi hypothetical protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.009 0.009
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0491 0.2992 0.2992
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.009 0.0105
Leishmania major cytochrome p450-like protein 0.0018 0.005 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.009 0.0442
Plasmodium vivax endoplasmin, putative 0.0027 0.0108 0.2374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.009 0.009
Schistosoma mansoni thyroid hormone receptor 0.0176 0.1036 0.1218
Plasmodium vivax plastid replication-repair enzyme, putative 0.0016 0.0035 0.0777
Echinococcus multilocularis twinkle protein, mitochondrial 0.0012 0.001 0.001
Brugia malayi DNA polymerase I family protein 0.0016 0.0035 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.009 0.0269
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0108 0.0928
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.0521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0145 0.1965
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0108 0.1407
Toxoplasma gondii helicase, putative 0.0016 0.0035 0.03
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.009 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.009 0.0269
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0884 0.104
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0108 0.1252
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0232 0.2
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0008
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0108 0.2329
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.008 0.1726
Brugia malayi hypothetical protein 0.0472 0.2872 0.9597
Schistosoma mansoni pyruvate dehydrogenase 0.0491 0.2992 0.352
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.005 0.0385
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1006 0.3307
Echinococcus granulosus snurportin 1 0.0301 0.1808 0.2127
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0024 0.0204
Echinococcus granulosus tar DNA binding protein 0.0062 0.0323 0.0379
Onchocerca volvulus 0.0012 0.0012 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0691 0.588
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0108 0.0329
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.009 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.005 0.0555
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Chlamydia trachomatis DNA polymerase I 0.0054 0.0275 1
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.005 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.005 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.009 0.0269
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0691 0.2247
Onchocerca volvulus 0.0012 0.0012 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0323 0.0379
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.009 0.0269
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0232 0.3115
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.009 0.0269
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0157 0.2
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0012 0.001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.009 0.0269
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.1178 0.1386
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.009 0.0105
Mycobacterium ulcerans putative regultory protein 0.0027 0.0108 0.1252
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.005 0.0555
Loa Loa (eye worm) hypothetical protein 0.0299 0.1801 0.6007
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0157 0.2987
Mycobacterium ulcerans DNA polymerase I 0.0054 0.0275 0.3757
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0027 0.0108 0.2329
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Entamoeba histolytica DNA topoisomerase II, putative 0.0027 0.0108 0.0928
Schistosoma mansoni ran 0.0021 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Plasmodium falciparum importin beta, putative 0.0028 0.0113 0.2491
Entamoeba histolytica hypothetical protein 0.0072 0.0384 0.3313
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0067 0.0143
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0108 0.1252
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.009 0.0105
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.012 0.037
Brugia malayi hypothetical protein 0.0012 0.0012 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.005 0.0555
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.009 0.0105
Loa Loa (eye worm) hypothetical protein 0.0035 0.0157 0.0497
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0024 0.0177
Brugia malayi steroid hormone receptor 0.0024 0.009 0.0269
Schistosoma mansoni pyruvate dehydrogenase 0.0464 0.2822 0.332
Brugia malayi Nuclear hormone receptor-like 1 0.0312 0.1881 0.6276
Plasmodium vivax patched family protein, putative 0.0012 0.0012 0.0259
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Schistosoma mansoni patched 1 0.0084 0.0462 0.0543
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1006 0.3307
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0108 0.1252
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0038 0.0177 0.0516
Loa Loa (eye worm) hypothetical protein 0.0472 0.2872 0.9597
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0024 0.052
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0177
Loa Loa (eye worm) hypothetical protein 0.0047 0.0232 0.0746
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.005 0.0087
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.005 0.0555
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0113 0.096
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0105 0.1217
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Schistosoma mansoni importin beta-1 0.0028 0.0113 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.009 0.0269
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0108 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.009 0.0269
Schistosoma mansoni nuclear receptor 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0491 0.2992 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0105 0.0273
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0024 0.0028
Echinococcus multilocularis snurportin 1 0.0301 0.1808 0.1808
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0108 0.2329
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0232 0.3237
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.009 0.0269
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0232 0.07
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0108 0.0281
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0323 0.105
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.005 0.1025
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.1159 0.3855
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0038 0.0177 0.0516
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0282 0.2401
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0291 0.0946
Schistosoma mansoni endoplasmin 0.0027 0.0108 0.0127
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0323 0.105
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0453 0.1446
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0323 0.038
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0108 0.2329
Echinococcus multilocularis microtubule associated protein 2 0.1376 0.8501 0.8501
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0113 0.0299
Onchocerca volvulus 0.0014 0.0024 0.0081
Brugia malayi RNA binding protein 0.0062 0.0323 0.105
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.009 0.0269
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0009 0.0009
Plasmodium falciparum endoplasmin, putative 0.0027 0.0108 0.2374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.009 0.0269
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0009 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.2528 0.2528
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0054 0.0275 0.3867
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0108 0.0281
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0009 0.0009
Mycobacterium leprae putative cytochrome p450 0.0018 0.005 0.1025
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.005 0.0385
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0157 0.3476
Echinococcus granulosus twinkle protein mitochondrial 0.0012 0.001 0.0011
Echinococcus multilocularis protein dispatched 1 0.0096 0.0536 0.0536
Echinococcus granulosus muscleblind protein 0.0298 0.1791 0.2107
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.1159 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0009 0.0011
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Echinococcus multilocularis survival motor neuron protein 1 0.0472 0.2872 0.2872
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.009 0.0269
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.005 0.0385
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.009 0.0105
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0024 0.0204
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0029
Brugia malayi TAR-binding protein 0.0062 0.0323 0.105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0049
Echinococcus granulosus Niemann Pick C1 protein 0.0281 0.1684 0.1981
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0108 0.0329
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.005 0.0555
Brugia malayi Cytochrome P450 family protein 0.0057 0.0291 0.0946
Echinococcus granulosus microtubule associated protein 2 0.1376 0.8501 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0691 1
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0024 0.0204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0018 0.0021
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0008
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0024 0.0207
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.005 0.0087
Echinococcus granulosus cpg binding protein 0.0031 0.013 0.0153
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0491 0.2992 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0108 0.1407
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0105 0.0321
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0108 0.0281
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0108 0.1407
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0384 0.0384
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.009 0.0105
Onchocerca volvulus 0.0014 0.0024 0.0081
Schistosoma mansoni DNA polymerase I 0.0016 0.0035 0.0041
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.147
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.005 0.0555
Schistosoma mansoni hypothetical protein 0.0096 0.0536 0.0631
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.005 0.0385
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.005 0.0555
Leishmania major hypothetical protein, conserved 0.0027 0.0108 0.0281
Plasmodium vivax importin-beta 2, putative 0.0028 0.0113 0.2491
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0323 0.105
Echinococcus granulosus expressed conserved protein 0.0184 0.1085 0.1277
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0105 0.0273
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0108 0.0915
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0108 0.0281
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0108 0.0281
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.009 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0416 0.2528 0.2974
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.009 0.0269
Schistosoma mansoni heat shock protein 0.0027 0.0108 0.0127
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0108 0.0281
Brugia malayi Patched related family protein 12 0.0012 0.0012 0.0008
Schistosoma mansoni hypothetical protein 0.0072 0.0384 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.009 0.0269
Loa Loa (eye worm) hypothetical protein 0.0103 0.058 0.1913
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.009 0.009
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.005 0.0555
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.009 0.0105
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0108 0.0915
Loa Loa (eye worm) hypothetical protein 0.0047 0.0232 0.0746
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0054 0.0275 1
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0019 0.0055 0.0467
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.005 0.0555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.009 0.0269
Loa Loa (eye worm) cytochrome P450 0.0018 0.005 0.0135
Echinococcus granulosus heat shock protein 90 0.0027 0.0108 0.0127
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.005 0.0385
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Brugia malayi nuclear hormone receptor 0.0024 0.009 0.0269
Echinococcus granulosus heat shock protein 0.0027 0.0108 0.0127
Brugia malayi hypothetical protein 0.0072 0.0384 0.1256
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.008 0.1726
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0108 0.0281
Brugia malayi CHE-14 protein 0.0084 0.0462 0.1517
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0009 0.0011
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.005 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Treponema pallidum DNA polymerase I (polA) 0.0054 0.0275 1
Leishmania major DNA topoisomerase ii 0.0027 0.0108 0.0281
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.005 0.0555
Echinococcus multilocularis muscleblind protein 1 0.0298 0.1791 0.1791
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0232 0.2
Loa Loa (eye worm) RNA binding protein 0.0062 0.0323 0.105
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0108 0.0281
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0024 0.0049
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0016 0.0035 0.0038
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0108 0.0915
Plasmodium falciparum telomerase reverse transcriptase 0.0083 0.0453 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0009 0.0011
Leishmania major telomerase reverse transcriptase, putative 0.0083 0.0453 0.1446
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0323 0.0379
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0108 0.1407
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0108 0.1407
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0536 0.1766
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0323 0.0379
Schistosoma mansoni hypothetical protein 0.0301 0.1808 0.2127
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0105 0.0321
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0108 0.0281
Brugia malayi Patched related family protein 4 0.0012 0.0012 0.0008
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0177
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0024 0.052
Schistosoma mansoni cpg binding protein 0.0029 0.012 0.0141
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0691 0.0813
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0108 0.1407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.005 0.0555
Schistosoma mansoni endoplasmin 0.0027 0.0108 0.0127
Onchocerca volvulus 0.0012 0.0012 0.0013
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0108 0.0329
Echinococcus granulosus FTZ F1 alpha 0.0024 0.009 0.0105
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0108 0.0127
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0108 0.1407
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0462 0.1517
Trichomonas vaginalis importin beta-1, putative 0.0023 0.008 0.1726
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.009 0.009
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0108 0.2374
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0016 0.0035 0.0038
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.005 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.009 0.0269
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0232 0.3237
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0067 0.0067
Toxoplasma gondii patched family protein 0.0012 0.0012 0.01
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0884 0.0884
Toxoplasma gondii patched family protein 0.0012 0.0012 0.01
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0024 0.053
Brugia malayi Cytochrome P450 family protein 0.0027 0.0105 0.0321
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0108 0.1407
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0024 0.0177
Toxoplasma gondii RNA-directed DNA polymerase 0.0083 0.0453 0.3855
Trypanosoma brucei telomerase reverse transcriptase 0.0083 0.0453 0.1446
Brugia malayi heat shock protein 90 0.0027 0.0108 0.0329
Onchocerca volvulus 0.0047 0.0232 0.1226
Schistosoma mansoni hypothetical protein 0.0416 0.2528 0.2974
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Brugia malayi Importin beta-1 subunit 0.0028 0.0113 0.0347
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0232 0.3115
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0323 0.0323
Brugia malayi Patched related family protein 10 0.0012 0.0012 0.0008
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.005 0.0385
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0329
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.009 0.0105
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.005 0.0385
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0269
Entamoeba histolytica Ran family GTPase 0.0021 0.0067 0.0574
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.005 0.0087
Brugia malayi protein C24B5.3 0.0012 0.0012 0.0008
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0049
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0108 0.1252
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0177
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.009 0.0105
Brugia malayi Muscleblind-like protein 0.0298 0.1791 0.5974
Onchocerca volvulus 0.0014 0.0024 0.0081
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0027 0.0108 0.2329
Onchocerca volvulus Protein patched homolog 0.0012 0.0012 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0301 0.181 0.6036
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0081 0.0443 0.0521
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0108 0.1252
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0232 0.0746
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0157 0.3476
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0047 0.0232 0.0746
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0232 0.07
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.147
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0691 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0462 0.0462
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.005 0.0423
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.009 0.009
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0067 0.147
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0024 0.0028
Schistosoma mansoni pyruvate dehydrogenase 0.0464 0.2822 0.332
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0018 0.0021
Mycobacterium leprae Probable two component sensor kinase MprB 0.0027 0.0108 0.3334
Leishmania major heat shock protein 83-1 0.0027 0.0108 0.0281
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0009 0.0011
Brugia malayi Patched family protein 0.0012 0.0012 0.0008
Schistosoma mansoni zinc finger protein 0.0012 0.0009 0.0011
Onchocerca volvulus 0.0024 0.009 0.0442
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.009 0.0105
Schistosoma mansoni hypothetical protein 0.0152 0.0884 0.104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.005 0.0385
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0105 0.0321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0008
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.009 0.009
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0009 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0691 0.0813
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0301 0.181 0.6036
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0108 0.0108
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0108 0.0281
Echinococcus multilocularis heat shock protein 0.0027 0.0108 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.005 0.0555
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0009 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0049
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0009 0.0011
Trypanosoma brucei heat shock protein, putative 0.0027 0.0108 0.0281
Echinococcus multilocularis expressed conserved protein 0.0184 0.1085 0.1085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0691 1
Brugia malayi hypothetical protein 0.0013 0.0018 0.0029
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0024 0.0049
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0067 0.0192
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0108 0.0915
Giardia lamblia Pms1-like protein 0.0027 0.0108 0.2374
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0108 0.2329

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.8 nM Inhibitory concentration against cloned human thyroid hormone receptor beta 1 ChEMBL. 16099653
IC50 (binding) = 1.8 nM Inhibitory concentration against cloned human thyroid hormone receptor beta 1 ChEMBL. 16099653
IC50 (binding) = 19 nM Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 ChEMBL. 16099653
IC50 (binding) = 19 nM Inhibitory concentration against cloned human thyroid hormone receptor alpha 1 ChEMBL. 16099653
Selectivity (binding) = 6 Ratio of IC50 of thyroid hormone receptor alpha 1 to that of thyroid hormone receptor beta 1 ChEMBL. 16099653
Selectivity (binding) = 6 Ratio of IC50 of thyroid hormone receptor alpha 1 to that of thyroid hormone receptor beta 1 ChEMBL. 16099653

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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