Detailed information for compound 340421

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.505 | Formula: C24H31NO8
  • H donors: 1 H acceptors: 4 LogP: 2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)[C@@H]1C[C@@H](OC(=O)[C@H](N)C)C(=O)C2[C@@]1(C)CCC1[C@@]2(C)C[C@H](OC1=O)c1cocc1
  • InChi: 1S/C24H31NO8/c1-12(25)20(27)32-16-9-15(21(28)30-4)23(2)7-5-14-22(29)33-17(13-6-8-31-11-13)10-24(14,3)19(23)18(16)26/h6,8,11-12,14-17,19H,5,7,9-10,25H2,1-4H3/t12-,14?,15-,16-,17-,19?,23-,24-/m0/s1
  • InChiKey: UCEVLQJFQXOAPM-GOLAIWNHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cell adhesion molecule 0.0009 0.0005 0.0003
Echinococcus multilocularis cpg binding protein 0.003 0.0086 0.0086
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0528 0.2019 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0025 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Onchocerca volvulus 0.0127 0.0464 0.0938
Echinococcus multilocularis calcium activated potassium channel 0.0021 0.005 0.005
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni cpg binding protein 0.0028 0.0079 0.012
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0051 0.0168 1
Echinococcus granulosus dnaJ subfamily B 0.0405 0.1541 0.1541
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0104 0.0373 0.0744
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0528 0.2019 0.4126
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0025 0.0025
Echinococcus granulosus hypothetical protein 0.0014 0.0025 0.0025
Echinococcus multilocularis tumor protein p63 0.0336 0.1274 0.1274
Echinococcus multilocularis titin 0.0011 0.001 0.001
Loa Loa (eye worm) G-protein coupled receptor 0.0127 0.0464 0.0947
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0003 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0127 0.0464 0.0947
Schistosoma mansoni nephrin 0.0047 0.0151 0.0233
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0127 0.0464 0.0464
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1267 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Entamoeba histolytica protein kinase, putative 0.0104 0.0373 0.0744
Echinococcus multilocularis dual specificity testis specific protein kinase 0.001 0.0009 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0101 0.0205
Onchocerca volvulus 0.0127 0.0464 0.0938
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0014 0.0025 0.004
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0025 0.0025
Schistosoma mansoni titin 0.0009 0.0005 0.0003
Brugia malayi MH2 domain containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus tumor protein p63 0.0336 0.1274 0.1274
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0127 0.0464 0.0724
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0127 0.0464 0.0947
Echinococcus multilocularis transient receptor potential gamma protein 0.0014 0.0025 0.0025
Giardia lamblia Kinase, PLK 0.1267 0.4894 1
Brugia malayi Dopamine receptor protein 1 0.0127 0.0464 0.0947
Trichomonas vaginalis CAMK family protein kinase 0.1267 0.4894 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1267 0.4894 0.4894
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0014 0.0025 0.0032
Loa Loa (eye worm) AUR protein kinase 0.0104 0.0373 0.0762
Onchocerca volvulus 0.0127 0.0464 0.0938
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0868 0.334 0.334
Trichomonas vaginalis CAMK family protein kinase 0.1267 0.4894 1
Loa Loa (eye worm) cytochrome P450 0.0051 0.0168 0.0343
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0051 0.0168 1
Echinococcus granulosus translocator protein 0.0528 0.2019 0.2019
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0009 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0051 0.0168 0.0816
Brugia malayi Tachykinin-like peptides receptor 99D 0.0127 0.0464 0.0947
Onchocerca volvulus 0.0127 0.0464 0.0938
Loa Loa (eye worm) calcium channel 0.0014 0.0025 0.0051
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0051 0.0168 0.0324
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Echinococcus multilocularis two pore calcium channel protein 1 0.0014 0.0025 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0051 0.0168 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0025 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0373 0.0756
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0127 0.0464 0.0724
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0003 0.0005
Schistosoma mansoni growth hormone secretagogue receptor 0.0127 0.0464 0.0724
Echinococcus multilocularis Immunoglobulin 0.0043 0.0135 0.0135
Schistosoma mansoni cell adhesion molecule 0.0009 0.0005 0.0003
Echinococcus multilocularis neuroglian 0.0047 0.0151 0.0151
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0014 0.0025 0.0025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0025 0.0427
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0025 0.0051
Loa Loa (eye worm) TK/KIN16 protein kinase 0.029 0.1097 0.2242
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0127 0.0464 0.0724
Schistosoma mansoni voltage-gated ion channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) CYP4Cod1 0.0077 0.0266 0.0544
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.0645 0.101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Brugia malayi AKH receptor 0.0127 0.0464 0.0947
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0042
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0051 0.0168 0.0816
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0014 0.0025 0.0051
Echinococcus granulosus tm gpcr rhodopsin 0.0752 0.2892 0.2892
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0127 0.0464 0.0464
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0014 0.0025 0.0051
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0025 0.0025
Toxoplasma gondii transporter, cation channel family protein 0.0014 0.0025 0.0427
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0025 0.0025
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Echinococcus granulosus contactin 0.0009 0.0005 0.0005
Echinococcus granulosus neuropeptide s receptor 0.0127 0.0464 0.0464
Leishmania major protein kinase, putative 0.0104 0.0373 0.0744
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0161 0.033
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Onchocerca volvulus 0.0127 0.0464 0.0938
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0154 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0127 0.0464 0.0724
Echinococcus granulosus neuropeptide receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Loa Loa (eye worm) TYRA-2 protein 0.0127 0.0464 0.0947
Echinococcus granulosus biogenic amine 5HT receptor 0.0868 0.334 0.334
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0025 0.0025
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0051 0.0168 0.0816
Schistosoma mansoni biogenic amine receptor 0.0127 0.0464 0.0724
Brugia malayi hypothetical protein 0.0213 0.0797 0.1628
Onchocerca volvulus 0.0528 0.2019 0.412
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1267 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Echinococcus granulosus aurora kinase A 0.0104 0.0373 0.0373
Brugia malayi ion channel NompC 0.0014 0.0025 0.0051
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0025 0.0034
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0025 0.0034
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0014 0.0025 0.0051
Echinococcus granulosus hemicentin 1 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni roundabout 0.0009 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Schistosoma mansoni hypothetical protein 0.0405 0.1541 0.2419
Echinococcus multilocularis serotonin receptor 0.0367 0.1394 0.1394
Schistosoma mansoni voltage-gated cation channel 0.0014 0.0025 0.0034
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0025 0.0025
Brugia malayi follicle stimulating hormone receptor 0.0127 0.0464 0.0947
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0127 0.0464 0.0947
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0014 0.0025 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0079 0.0162
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0003 0.0003
Echinococcus granulosus voltage dependent calcium channel 0.0014 0.0025 0.0025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0127 0.0464 0.0724
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0129
Toxoplasma gondii hypothetical protein 0.0014 0.0025 0.0427
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Schistosoma mansoni adenoreceptor 0.0127 0.0464 0.0724
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0051 0.0168 0.0816
Echinococcus granulosus dro:myosuppressin receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.003
Echinococcus granulosus ryanodine receptor 44f 0.0014 0.0025 0.0025
Echinococcus granulosus G protein coupled receptor 139 0.0127 0.0464 0.0464
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0026 0.0026
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0025 0.0025
Schistosoma mansoni tyrosine kinase 0.0013 0.002 0.0027
Echinococcus granulosus alpha 1A adrenergic receptor 0.0127 0.0464 0.0464
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0127 0.0464 0.0724
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0025 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.0005 0.0011
Brugia malayi cation channel family protein 0.0014 0.0025 0.0051
Onchocerca volvulus Tyrosine kinase homolog 0.0246 0.0926 0.1884
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0495 0.0495
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Echinococcus granulosus tar DNA binding protein 0.0135 0.0495 0.0495
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0048 0.0156 0.0156
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0373 0.0756
Schistosoma mansoni transient receptor potential channel 0.0015 0.0026 0.0036
Echinococcus granulosus voltage gated hydrogen channel 1 0.0014 0.0025 0.0025
Onchocerca volvulus 0.0127 0.0464 0.0938
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Brugia malayi Prion-like- 0.0009 0.0005 0.0011
Onchocerca volvulus 0.0011 0.001 0.001
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0014 0.0025 0.0051
Loa Loa (eye worm) AUR protein kinase 0.0104 0.0373 0.0762
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0051 0.0168 0.0816
Echinococcus granulosus activin receptor type 0.001 0.0009 0.0009
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0051 0.0168 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0104 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0367 0.1394 0.2849
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0104 0.0373 0.0744
Brugia malayi CXXC zinc finger family protein 0.0028 0.0079 0.0162
Toxoplasma gondii hypothetical protein 0.0014 0.0025 0.0427
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0127 0.0464 0.0464
Trypanosoma brucei aurora B kinase 0.0104 0.0373 0.0744
Echinococcus granulosus sodium leak channel non selective protein 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0043 0.0135 0.0277
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Echinococcus granulosus 7tm_1 domain containing protein 0.0127 0.0464 0.0464
Schistosoma mansoni titin 0.0011 0.001 0.0011
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0061
Brugia malayi Fibronectin type III domain containing protein 0.0043 0.0135 0.0277
Loa Loa (eye worm) G-protein coupled receptor 0.0127 0.0464 0.0947
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0014 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0025 0.0025
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0051 0.0168 0.0816
Loa Loa (eye worm) hypothetical protein 0.0052 0.0172 0.0351
Echinococcus granulosus tyrosine protein kinase otk 0.0009 0.0005 0.0005
Echinococcus granulosus calcium activated potassium channel 0.0021 0.005 0.005
Brugia malayi MH2 domain containing protein 0.0009 0.0003 0.0007
Brugia malayi hypothetical protein 0.0014 0.0025 0.0051
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1267 0.4894 0.4894
Schistosoma mansoni neuropeptide receptor 0.0127 0.0464 0.0724
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.001 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.1267 0.4894 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0127 0.0464 0.0947
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0051 0.0168 0.0816
Schistosoma mansoni neuropeptide receptor 0.0127 0.0464 0.0724
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Echinococcus granulosus defective proboscis extension response 0.0043 0.0135 0.0135
Schistosoma mansoni amine GPCR 0.0127 0.0464 0.0724
Schistosoma mansoni protein kinase 0.001 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0495 0.1011
Echinococcus granulosus neuropeptide Y receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.0205
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0051 0.0168 0.0816
Toxoplasma gondii transporter, cation channel family protein 0.0014 0.0025 0.0427
Trypanosoma cruzi polo-like protein kinase, putative 0.1267 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Onchocerca volvulus 0.0127 0.0464 0.0938
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0476 0.0972
Loa Loa (eye worm) cytochrome P450 family protein 0.0182 0.0676 0.1381
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0014 0.0025 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Schistosoma mansoni cell adhesion molecule 0.0048 0.0156 0.024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0373 0.0756
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0266 0.0544
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0752 0.2892 0.2892
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0014 0.0025 0.0034
Echinococcus multilocularis somatostatin receptor 0.0127 0.0464 0.0464
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0373 0.0756
Loa Loa (eye worm) neuropeptide F receptor 0.0127 0.0464 0.0947
Onchocerca volvulus 0.0127 0.0464 0.0938
Echinococcus granulosus g protein coupled receptor 0.0127 0.0464 0.0464
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0104 0.0373 0.5
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0051 0.0168 0.0816
Echinococcus granulosus neuropeptide Y receptor 0.0127 0.0464 0.0464
Brugia malayi Cytochrome P450 family protein 0.0051 0.0168 0.0343
Schistosoma mansoni ryanodine receptor related 0.0014 0.0025 0.0034
Echinococcus granulosus lachesin 0.0009 0.0005 0.0005
Echinococcus multilocularis voltage dependent calcium channel 0.0014 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0042
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0014 0.0025 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0051 0.0168 0.0324
Echinococcus granulosus dual specificity testis-specific protein kinase 0.001 0.0009 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0014 0.0025 0.0025
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0025 0.0025
Echinococcus granulosus g protein coupled receptor 0.0127 0.0464 0.0464
Schistosoma mansoni transient receptor potential channel 0.0014 0.0025 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.1267 0.4894 1
Brugia malayi putative neuropeptide receptor 0.0127 0.0464 0.0947
Brugia malayi Cytochrome P450 family protein 0.0077 0.0266 0.0544
Echinococcus granulosus expressed protein 0.0009 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0127 0.0464 0.0724
Echinococcus multilocularis G protein coupled receptor 139 0.0127 0.0464 0.0464
Brugia malayi serine/threonine protein kinase 6 0.0104 0.0373 0.0762
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0127 0.0464 0.0724
Schistosoma mansoni amine GPCR 0.0127 0.0464 0.0724
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0003 0.5
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0014 0.0025 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Trypanosoma brucei polo-like protein kinase 0.1267 0.4894 1
Echinococcus multilocularis sodium channel protein 0.0014 0.0025 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0003 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Echinococcus granulosus neuropeptide receptor 0.0127 0.0464 0.0464
Onchocerca volvulus Serine\/threonine kinase homolog 0.1267 0.4894 1
Schistosoma mansoni hypothetical protein 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0051 0.0168 0.0816
Schistosoma mansoni hypothetical protein 0.0127 0.0464 0.0724
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0014 0.0025 0.0025
Schistosoma mansoni amine GPCR 0.0127 0.0464 0.0724
Onchocerca volvulus 0.0127 0.0464 0.0938
Onchocerca volvulus 0.0528 0.2019 0.412
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0051 0.0168 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0009 0.0005 0.0003
Echinococcus multilocularis allatostatin A receptor 0.0127 0.0464 0.0464
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0495 0.0773
Leishmania major cytochrome p450-like protein 0.0051 0.0168 0.0324
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0014 0.0025 0.0032
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0014 0.0025 0.0025
Echinococcus granulosus voltage dependent calcium channel 0.0014 0.0025 0.0025
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0367 0.1394 0.2849
Loa Loa (eye worm) voltage-gated calcium channel 0.0014 0.0025 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Echinococcus multilocularis voltage dependent calcium channel 0.0014 0.0025 0.0025
Trypanosoma cruzi cytochrome P450, putative 0.0077 0.0266 0.0526
Echinococcus granulosus Smad4 0.0009 0.0003 0.0003
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0127 0.0464 0.0947
Onchocerca volvulus 0.0127 0.0464 0.0938
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0127 0.0464 0.0947
Brugia malayi neuropeptide F receptor 0.0127 0.0464 0.0947
Entamoeba histolytica protein kinase , putative 0.0104 0.0373 0.0744
Loa Loa (eye worm) voltage-dependent calcium channel 0.0014 0.0025 0.0051
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0014 0.0025 0.0025
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0051 0.0168 0.0816
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0007
Brugia malayi Melatonin receptor type 1A 0.0127 0.0464 0.0947
Brugia malayi GnHR receptor homolog 0.0127 0.0464 0.0947
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2581 1 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0051 0.0168 0.0816
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0014 0.0025 0.004
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0127 0.0464 0.0464
Echinococcus granulosus hypothetical protein 0.0127 0.0464 0.0464
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0025 0.0034
Leishmania major hypothetical protein, unknown function 0.0014 0.0025 0.0032
Echinococcus multilocularis conserved hypothetical protein 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0051 0.0168 1
Trichomonas vaginalis CAMK family protein kinase 0.1267 0.4894 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0127 0.0464 0.0464
Schistosoma mansoni opsin-like receptor 0.0127 0.0464 0.0724
Echinococcus granulosus two pore calcium channel protein 2 0.0014 0.0025 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0154 0.0154
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0127 0.0464 0.0464
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Brugia malayi serine/threonine-protein kinase plk-2 0.1267 0.4894 1
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0025 0.0025
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Brugia malayi Smad1 0.0009 0.0003 0.0007
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0043 0.0135 0.0208
Echinococcus multilocularis neuroglian 0.0009 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0016 0.003 0.0061
Echinococcus multilocularis translocator protein 0.0528 0.2019 0.2019
Echinococcus multilocularis smad 0.0009 0.0003 0.0003
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0043 0.0135 0.0135
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0014 0.0025 0.0025
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.0005 0.0011
Onchocerca volvulus 0.0528 0.2019 0.412
Echinococcus granulosus orexin receptor type 2 0.0127 0.0464 0.0464
Brugia malayi voltage-dependent calcium channel 0.0014 0.0025 0.0051
Echinococcus multilocularis potassium voltage gated channel protein 0.0014 0.0025 0.0025
Echinococcus granulosus cpg binding protein 0.003 0.0086 0.0086
Brugia malayi TspO/MBR family protein 0.0528 0.2019 0.4126
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0051 0.0168 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0014 0.0025 0.0025
Onchocerca volvulus Neuropeptide F receptor homolog 0.0127 0.0464 0.0938
Onchocerca volvulus 0.0127 0.0464 0.0938
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0051 0.0168 0.0816
Echinococcus multilocularis fmrfamide receptor 0.0127 0.0464 0.0464
Onchocerca volvulus 0.0127 0.0464 0.0938
Brugia malayi protein unc-22 0.0011 0.001 0.0021
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.016 0.0246
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0014 0.0025 0.0034
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.003 0.0061
Echinococcus granulosus roundabout 2 0.0009 0.0005 0.0005
Echinococcus granulosus allatostatin A receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis hemicentin 1 0.0009 0.0005 0.0005
Echinococcus granulosus sex peptide receptor 0.0127 0.0464 0.0464
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Echinococcus multilocularis fmrfamide receptor 0.0127 0.0464 0.0464
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0127 0.0464 0.0724
Schistosoma mansoni neuropeptide receptor 0.0127 0.0464 0.0724
Echinococcus granulosus short transient receptor potential channel 6 0.0015 0.0026 0.0026
Entamoeba histolytica serine/threonine protein kinase, putative 0.1267 0.4894 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.003
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0495 0.0773
Schistosoma mansoni neuropeptide f receptor 76f 0.0127 0.0464 0.0724
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0014 0.0025 0.0051
Brugia malayi olfactory channel protein osm-9 0.0015 0.0026 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Echinococcus multilocularis dro:myosuppressin receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Trypanosoma cruzi cytochrome P450, putative 0.0077 0.0266 0.0526
Brugia malayi TAR-binding protein 0.0135 0.0495 0.1011
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0025 0.0044
Echinococcus multilocularis orexin receptor type 2 0.0127 0.0464 0.0464
Echinococcus granulosus tachykinin peptides receptor 99D 0.0127 0.0464 0.0464
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0025 0.0025
Trypanosoma cruzi polo-like protein kinase, putative 0.1267 0.4894 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0025 0.0025
Schistosoma mansoni two-pore calcium channel 0.0014 0.0025 0.0034
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0042
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0051 0.0168 0.0324
Schistosoma mansoni neuroglian 0.0009 0.0005 0.0003
Brugia malayi hypothetical protein 0.0043 0.0135 0.0277
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0014 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0454 0.1733 0.3537
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0051 0.0168 0.0324
Echinococcus multilocularis short transient receptor potential channel 6 0.0014 0.0025 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0203 0.0314
Onchocerca volvulus 0.0127 0.0464 0.0938
Brugia malayi Immunoglobulin I-set domain containing protein 0.029 0.1097 0.2242
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Brugia malayi serine/threonine-protein kinase 6 0.0104 0.0373 0.0762
Brugia malayi G protein-coupled receptor F59B2.13 0.0127 0.0464 0.0947
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0014 0.0025 0.0025
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0127 0.0464 0.0947
Echinococcus multilocularis neuropeptide Y receptor 0.0127 0.0464 0.0464
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0495 0.1011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Loa Loa (eye worm) hypothetical protein 0.0528 0.2019 0.4126
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0025 0.0034
Echinococcus multilocularis transfer RNA-Gly 0.0014 0.0025 0.0025
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0154 0.0238
Mycobacterium leprae Conserved hypothetical protein 0.0051 0.0168 1
Schistosoma mansoni neuropeptide F-like receptor 0.0127 0.0464 0.0724
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0051 0.0168 1
Echinococcus multilocularis peroxidasin 0.0009 0.0005 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Echinococcus granulosus potassium large conductance calcium activated 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0528 0.2019 0.4126
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni nephrin 0.0009 0.0005 0.0003
Echinococcus granulosus Immunoglobulin 0.0043 0.0135 0.0135
Echinococcus multilocularis ryanodine receptor 44f 0.0014 0.0025 0.0025
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0127 0.0464 0.0464
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0161 0.033
Onchocerca volvulus 0.0028 0.0079 0.0152
Schistosoma mansoni hypothetical protein 0.0127 0.0464 0.0724
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0051 0.0168 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0014 0.0025 0.0051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0135 0.0277
Loa Loa (eye worm) hypothetical protein 0.0043 0.0135 0.0277
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0051 0.0168 0.0816
Onchocerca volvulus 0.0127 0.0464 0.0938
Echinococcus granulosus roundabout 2 0.0052 0.0172 0.0172
Echinococcus multilocularis Smad4 0.0009 0.0003 0.0003
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0127 0.0464 0.0724
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0104 0.0373 0.0744
Schistosoma mansoni serine/threonine protein kinase 0.1267 0.4894 0.7692
Echinococcus granulosus twitchin 0.0053 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Schistosoma mansoni voltage-dependent calcium channel 0.0014 0.0025 0.0034
Brugia malayi cytochrome P450 0.0051 0.0168 0.0343
Brugia malayi G protein-coupled receptor 0.0127 0.0464 0.0947
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0154 0.0154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0051 0.0168 1
Echinococcus multilocularis 0.0051 0.0168 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0454 0.1733 0.3537
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0025 0.0025
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0005 0.0003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0003 0.0003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0127 0.0464 0.0464
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0025 0.0025
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0014 0.0025 0.0032
Schistosoma mansoni hypothetical protein 0.0127 0.0464 0.0724
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni histamine h1 receptor 0.0127 0.0464 0.0724
Loa Loa (eye worm) ion channel NompC 0.0014 0.0025 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0003
Echinococcus multilocularis neuropeptide s receptor 0.0127 0.0464 0.0464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0014 0.0025 0.0051
Echinococcus granulosus titin 0.0011 0.001 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Schistosoma mansoni hypothetical protein 0.0051 0.0168 0.0259
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0014 0.0025 0.0051
Echinococcus multilocularis G-protein coupled receptor, putative 0.0127 0.0464 0.0464
Echinococcus granulosus two pore calcium channel protein 1 0.0014 0.0025 0.0025
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0025 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0832 0.3201 0.3201
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0025 0.0025
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0127 0.0464 0.0724
Echinococcus granulosus GPCR family 2 0.0016 0.003 0.003
Brugia malayi MH2 domain containing protein 0.013 0.0476 0.0972
Entamoeba histolytica protein kinase, putative 0.0104 0.0373 0.0744
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0373 0.0581
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0051 0.0168 0.0816
Echinococcus multilocularis sex peptide receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0014 0.0025 0.0025
Schistosoma mansoni amine GPCR 0.0127 0.0464 0.0724
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0025 0.0025
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0025 0.0051
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0051 0.0168 0.0816
Toxoplasma gondii cytochrome p450 superfamily protein 0.0051 0.0168 0.4356
Echinococcus multilocularis roundabout 2 0.0052 0.0172 0.0172
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0025 0.0025
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0014 0.0025 0.0051
Echinococcus granulosus TRP transient receptor potential channel 0.0014 0.0025 0.0025
Toxoplasma gondii transporter, cation channel family protein 0.0014 0.0025 0.0427
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0127 0.0464 0.0724
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0495 0.0773
Echinococcus granulosus g protein coupled receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0014 0.0025 0.0051
Echinococcus granulosus g-protein coupled receptor 0.0127 0.0464 0.0464
Plasmodium falciparum serine/threonine protein kinase, putative 0.0104 0.0373 1
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0042
Echinococcus granulosus shaker cognate 0.0014 0.0025 0.0025
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0127 0.0464 0.0464
Echinococcus granulosus sodium channel protein 0.0014 0.0025 0.0025
Brugia malayi Serotonin receptor 0.0127 0.0464 0.0947
Brugia malayi Peroxidasin 0.0009 0.0005 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Schistosoma mansoni neuropeptide F-like receptor 0.0127 0.0464 0.0724
Echinococcus granulosus transient receptor potential gamma protein 0.0014 0.0025 0.0025
Schistosoma mansoni alpha-1 adrenergic receptor 0.0127 0.0464 0.0724
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Brugia malayi putative neuropeptide receptor NPR1 0.0127 0.0464 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0051 0.0168 1
Brugia malayi neuropeptide F receptor 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0043 0.0135 0.0277
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0026 0.0026
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0495 0.0773
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0005 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0154 0.0315
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Loa Loa (eye worm) RNA binding protein 0.0135 0.0495 0.1011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0172 0.0351
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0127 0.0464 0.0724
Schistosoma mansoni neuropeptide receptor 0.0127 0.0464 0.0724
Echinococcus multilocularis hemicentin 1 0.0009 0.0005 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0127 0.0464 0.0464
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0127 0.0464 0.0464
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0025 0.0025
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.3086 0.3086
Schistosoma mansoni 60S ribosomal protein L21 0.0014 0.0025 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0003 0.0007
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0077 0.0266 0.1305
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0043 0.0135 0.0208
Echinococcus multilocularis lachesin 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0051 0.0168 0.0324
Echinococcus granulosus cytochrome P450 2K1 0.0051 0.0168 0.0168
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0014 0.0025 0.0032
Echinococcus granulosus titin 0.0011 0.001 0.001
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0014 0.0025 0.0034
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0025 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni biogenic amine (5HT) receptor 0.0367 0.1394 0.2188
Echinococcus multilocularis g protein coupled receptor 0.0127 0.0464 0.0464
Leishmania major hypothetical protein, conserved 0.0014 0.0025 0.0032
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0025 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Brugia malayi RNA binding protein 0.0135 0.0495 0.1011
Brugia malayi Transient-receptor-potential like protein 0.0014 0.0025 0.0051
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0014 0.0025 0.0025
Schistosoma mansoni transient receptor potential channel 0.0014 0.0025 0.0034
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0104 0.0373 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.001 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.003
Trypanosoma brucei cytochrome P450, putative 0.0077 0.0266 0.0526
Echinococcus multilocularis neuropeptide receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis tyrosine protein kinase otk 0.0009 0.0005 0.0005
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus short transient receptor potential channel 6 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0025 0.0044
Mycobacterium leprae putative cytochrome p450 0.0051 0.0168 1
Loa Loa (eye worm) neuropeptide F receptor 0.0127 0.0464 0.0947
Schistosoma mansoni kinase 0.1645 0.6362 1
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Onchocerca volvulus 0.0014 0.0025 0.004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0025 0.0025
Echinococcus granulosus neuroglian 0.0047 0.0151 0.0151
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0025 0.0034
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0127 0.0464 0.0938
Brugia malayi hypothetical protein 0.0127 0.0464 0.0947
Echinococcus granulosus roundabout 2 0.0009 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0127 0.0464 0.0724
Echinococcus multilocularis g protein coupled receptor 0.0127 0.0464 0.0464
Brugia malayi ORL1-like opioid receptor 0.0127 0.0464 0.0947
Echinococcus multilocularis two pore calcium channel protein 2 0.0014 0.0025 0.0025
Schistosoma mansoni biogenic amine receptor 0.0127 0.0464 0.0724
Schistosoma mansoni cytochrome P450 0.0051 0.0168 0.0259
Schistosoma mansoni opsin-like receptor 0.0127 0.0464 0.0724
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0051 0.0168 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0051 0.0168 0.0816
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0016 0.0031 0.0062
Loa Loa (eye worm) Smad1 0.0009 0.0003 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0051 0.0168 1
Echinococcus granulosus fmrfamide receptor 0.0127 0.0464 0.0464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Leishmania major cytochrome p450-like protein 0.0051 0.0168 0.0324
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0174 0.0645 0.1319
Echinococcus granulosus neuropeptides capa receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Echinococcus multilocularis serotonin receptor 0.0367 0.1394 0.1394
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0528 0.2019 0.4126
Schistosoma mansoni myosin xvIII 0.0127 0.0464 0.0724
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0051 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0053
Echinococcus multilocularis g protein coupled receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis potassium large conductance calcium activated 0.0014 0.0025 0.0025
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0025 0.0051
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0025 0.0025
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.1541 0.1541
Echinococcus multilocularis ferritin 0.0009 0.0003 0.0003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0127 0.0464 0.0947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0154 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Trichomonas vaginalis CAMK family protein kinase 0.1267 0.4894 1
Schistosoma mansoni cell adhesion molecule 0.0009 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Toxoplasma gondii aurora kinase 0.0104 0.0373 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0011 0.001 0.0021
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0009 0.0009
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0154 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0051 0.0168 1
Echinococcus multilocularis expressed protein 0.0009 0.0003 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0495 0.1011
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0051 0.0168 0.0816
Echinococcus granulosus transient receptor potential cation channel 0.0015 0.0026 0.0026
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0025 0.0025
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Schistosoma mansoni biogenic amine receptor 0.0127 0.0464 0.0724
Brugia malayi Dopamine receptor 0.0127 0.0464 0.0947
Brugia malayi RE15519p 0.0127 0.0464 0.0947
Echinococcus granulosus neuropeptide FF receptor 2 0.0127 0.0464 0.0464
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0051 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Trichomonas vaginalis CAMK family protein kinase 0.1267 0.4894 1
Brugia malayi Cytochrome P450 family protein 0.0077 0.0266 0.0544
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0025 0.0025
Echinococcus granulosus peptide allatostatin:somatostatin 0.0127 0.0464 0.0464
Echinococcus multilocularis rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Echinococcus multilocularis g-protein coupled receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Loa Loa (eye worm) AUR protein kinase 0.0104 0.0373 0.0762
Echinococcus granulosus somatostatin receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0014 0.0025 0.0051
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0014 0.0025 0.0025
Echinococcus granulosus peroxidasin 0.0009 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0034 0.0101 0.0153
Echinococcus multilocularis neuropeptides capa receptor 0.0127 0.0464 0.0464
Schistosoma mansoni protein kinase 0.001 0.0009 0.001
Onchocerca volvulus 0.0127 0.0464 0.0938
Schistosoma mansoni septate junction protein 0.0009 0.0005 0.0003
Echinococcus multilocularis short transient receptor potential channel 6 0.0015 0.0026 0.0026
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0014 0.0025 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0051
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0014 0.0025 0.0051
Brugia malayi serine/threonine kinase 12 0.0104 0.0373 0.0762
Brugia malayi Protein kinase domain containing protein 0.0174 0.0645 0.1319
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0014 0.0025 0.0025
Echinococcus granulosus tm gpcr rhodopsin 0.0127 0.0464 0.0464
Brugia malayi larval opioid receptor 0.0127 0.0464 0.0947
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0135 0.0277
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0476 0.0972
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0161 0.033
Brugia malayi cation channel family protein 0.0014 0.0025 0.0051
Echinococcus multilocularis neuropeptide Y receptor 0.0127 0.0464 0.0464
Brugia malayi G-protein coupled receptor 0.0127 0.0464 0.0947
Schistosoma mansoni biogenic amine (5HT) receptor 0.0868 0.334 0.5248
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0528 0.2019 0.317
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0014 0.0025 0.0051
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0051 0.0168 0.0816
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0025 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0127 0.0464 0.0724
Echinococcus multilocularis neuropeptides capa receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) CAMK protein kinase 0.0011 0.001 0.0021
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0127 0.0464 0.0464
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0127 0.0464 0.0464
Echinococcus multilocularis Immunoglobulin 0.0043 0.0135 0.0135
Onchocerca volvulus 0.0238 0.0895 0.182
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0127 0.0464 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0051 0.0168 1
Schistosoma mansoni septate junction protein 0.0009 0.0005 0.0003
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0014 0.0025 0.0025
Brugia malayi Dopamine receptor protein 2 0.0127 0.0464 0.0947
Echinococcus multilocularis activin receptor type 0.001 0.0009 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0011
Leishmania major cytochrome p450-like protein 0.0077 0.0266 0.0526
Echinococcus granulosus neuroglian 0.0009 0.0005 0.0005
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0832 0.3201 0.3201
Schistosoma mansoni protein kinase 0.001 0.0009 0.001
Echinococcus granulosus potassium voltage gated channel protein 0.0014 0.0025 0.0025
Schistosoma mansoni cpg binding protein 0.003 0.0086 0.0129
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0127 0.0464 0.0724
Schistosoma mansoni transient receptor potential channel 4 0.0014 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Loa Loa (eye worm) hypothetical protein 0.0043 0.0135 0.0277
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0127 0.0464 0.0464
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0025 0.0025
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0373 0.0744
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0318
Echinococcus multilocularis roundabout 2 0.0009 0.0005 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0127 0.0464 0.0464
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0005 0.0005
Echinococcus multilocularis twitchin 0.0011 0.001 0.001
Brugia malayi Serotonin receptor 0.0127 0.0464 0.0947
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0014 0.0025 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0135 0.0277
Schistosoma mansoni amine GPCR 0.0127 0.0464 0.0724
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0051 0.0168 0.0816
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0014 0.0025 0.0032
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.003 0.0061
Echinococcus granulosus neuropeptides capa receptor 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0014 0.0025 0.0034
Echinococcus multilocularis aurora kinase A 0.0104 0.0373 0.0373
Echinococcus granulosus 7TM GPCR rhodopsin 0.0127 0.0464 0.0464
Loa Loa (eye worm) voltage-gated potassium channel 0.0014 0.0025 0.0051
Loa Loa (eye worm) ryanodine receptor 0.0014 0.0025 0.0051
Brugia malayi Cytochrome P450 family protein 0.0182 0.0676 0.1381
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0051 0.0168 1
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0025 0.0034
Echinococcus multilocularis neuropeptide receptor A26 0.0127 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0051 0.0168 1
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.001 0.0011
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0127 0.0464 0.0947
Schistosoma mansoni protein kinase 0.0104 0.0373 0.0581
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0025 0.0025
Onchocerca volvulus 0.0049 0.016 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0495 0.0773
Echinococcus granulosus ferritin 0.0009 0.0003 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.0005 0.0011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0178 0.464
Echinococcus multilocularis shaker cognate 0.0014 0.0025 0.0025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0025 0.0427
Schistosoma mansoni calcium-activated potassium channel 0.0014 0.0025 0.0034
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0025 0.0025
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0014 0.0025 0.0025
Brugia malayi sulfakinin receptor protein 0.0127 0.0464 0.0947
Onchocerca volvulus 0.0528 0.2019 0.412
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0266 0.0544
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0327
Echinococcus granulosus biogenic amine 5HT receptor 0.0367 0.1394 0.1394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0154 0.0154
Echinococcus multilocularis GPCR, family 2 0.0016 0.003 0.003
Loa Loa (eye worm) melatonin receptor type 1A 0.0127 0.0464 0.0947
Echinococcus granulosus neuropeptide receptor A26 0.0127 0.0464 0.0464
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0127 0.0464 0.0464
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0138
Echinococcus multilocularis roundabout 2 0.0009 0.0005 0.0005
Echinococcus granulosus smad 0.0009 0.0003 0.0003
Schistosoma mansoni vesicular amine transporter 0.0057 0.0191 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.0464 0.0464
Trypanosoma cruzi aurora B kinase, putative 0.0104 0.0373 0.0744
Loa Loa (eye worm) hypothetical protein 0.005 0.0161 0.033
Onchocerca volvulus 0.0127 0.0464 0.0938
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0154 0.0315
Brugia malayi G-protein coupled receptor 0.0127 0.0464 0.0947
Onchocerca volvulus 0.0127 0.0464 0.0938
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0006
Echinococcus granulosus serotonin receptor 0.0127 0.0464 0.0464
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0025 0.0025
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0051 0.0168 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0127 0.0464 0.0464

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0 nM Effective concentration for activation of human Opioid receptor kappa 1 expressed in chinese hamster ovary cells to enhance [35S]-GTP-gammaS, binding; ND=Not determined ChEMBL. 15869877
Efficacy (functional) 0 % Activation of human Opioid receptor kappa 1 expressd in chinese hamster ovary cells to enhance [35S]-GTP-gammaS, binding compared to U50,488H; ND=Not determined ChEMBL. 15869877
Ki (binding) > 10000 nM Inhibition of [3H]-diprenorphine binding to human Opioid receptor kappa 1 expressed in chinese hamster ovary cells ChEMBL. 15869877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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