Detailed information for compound 401390

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1487.35 | Formula: C76H73Cl2N9O19
  • H donors: 16 H acceptors: 15 LogP: 8.64 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCc1ccc(cc1)CNCc1c(O)cc2c(c1O)c1cc(ccc1O)C1NC(=O)C3NC(=O)C4NC(=O)C(Cc5ccc(Oc6cc3cc(Oc3ccc(C(C(C(=O)N[C@H]2C(=O)NC)NC1=O)O)cc3Cl)c6O)c(Cl)c5)NC(=O)C(NC(=O)OC(C)(C)C)c1cc(Oc2cc4cc(O)c2)c(O)cc1
  • InChi: 1S/C76H73Cl2N9O19/c1-6-7-8-34-9-11-35(12-10-34)32-80-33-46-52(91)31-45-58(66(46)93)44-25-37(14-17-50(44)89)59-71(98)86-64(74(101)85-63(45)69(96)79-5)65(92)39-16-20-54(48(78)26-39)105-57-29-41-28-56(67(57)94)104-53-19-13-36(21-47(53)77)22-49-68(95)82-61(72(99)84-62(41)73(100)83-59)40-23-42(88)30-43(24-40)103-55-27-38(15-18-51(55)90)60(70(97)81-49)87-75(102)106-76(2,3)4/h9-21,23-31,49,59-65,80,88-94H,6-8,22,32-33H2,1-5H3,(H,79,96)(H,81,97)(H,82,95)(H,83,100)(H,84,99)(H,85,101)(H,86,98)(H,87,102)/t49?,59?,60?,61?,62?,63-,64?,65?/m1/s1
  • InChiKey: KCQICHSTQWOVND-BPDCHCOKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0947 0.4411
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.0466 0.2142
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0113
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0087 0.0198 0.4423
Trypanosoma brucei polo-like protein kinase 0.0187 0.0466 0.4348
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0227 0.0576 0.5784
Toxoplasma gondii FATC domain-containing protein 0.0221 0.0559 0.5609
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0248 0.071
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0174 0.0432 0.2029
Echinococcus granulosus expressed protein 0.0363 0.0944 0.0944
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0405 0.1055 0.2864
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0046 0.0087 0.0351
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0247 0.1105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.1055 0.4924
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0279 0.1256
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0387 0.1008 0.4699
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0117 0.0279 0.1256
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0248 0.0757
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0018 0.0025
Echinococcus multilocularis high voltage activated calcium channel beta 0.0084 0.019 0.019
Trypanosoma cruzi hypothetical protein, conserved 0.1286 0.3437 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0013 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0096 0.0395
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Giardia lamblia Casein kinase II beta chain 0.0036 0.0059 0.0167
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0047 0.0046
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0405 0.1055 0.4924
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.0466 0.0466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0387 0.1007 0.4696
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0248 0.1112
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0052 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0995 0.4638
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.0209
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0013 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0022 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0459 0.1201 0.1201
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0022 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0052 0.0187
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.004 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0242 0.0617 0.2854
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0395 0.103 0.4838
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0207 0.052 0.2443
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0395 0.103 0.2989
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0013 0.0038
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.005 0.0096 0.0096
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0248 0.0248
Trypanosoma cruzi casein kinase II, putative 0.0133 0.0322 0.0926
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0387 0.1007 0.4696
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0084 0.019 0.0581
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.004 0.0376
Loa Loa (eye worm) hypothetical protein 0.0227 0.0576 0.1986
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0226 0.0572 0.4659
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0059 0.0158
Toxoplasma gondii hypothetical protein 0.0067 0.0142 0.1408
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0044
Onchocerca volvulus 0.0026 0.0033 0.0404
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0102 0.0237 0.0677
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0175 0.0435 0.1992
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0207 0.052 0.052
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.059 0.1557 0.7293
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0023
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.036 0.0934 0.2851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.0926 0.4316
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0248 0.0664
Echinococcus granulosus geminin 0.0164 0.0405 0.0404
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0033 0.0113
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0217 0.0549 0.2531
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0322 0.1463
Onchocerca volvulus 0.004 0.007 0.0866
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0405 0.1055 0.4924
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.0358 0.1234
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0405 0.1055 0.3061
Plasmodium falciparum casein kinase 2, alpha subunit 0.0133 0.0322 0.7351
Plasmodium vivax SET domain protein, putative 0.0029 0.004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0098 0.0227 0.0781
Giardia lamblia Hypothetical protein 0.0087 0.0198 0.139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0995 0.4638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0346 0.0898 0.4182
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.004 0.0127
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0175 0.0435 0.0434
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0313 0.0808 0.2342
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0031 0.0047 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0959 0.4468
Brugia malayi Csnk2b protein 0.0036 0.0059 0.0275
Loa Loa (eye worm) RecQ helicase 0.0021 0.0018 0.0062
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0013 0.0046
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0802 0.213 1
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0059 0.112
Schistosoma mansoni hypothetical protein 0.0164 0.0405 0.1235
Brugia malayi phosphofructokinase 0.0106 0.0248 0.1165
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0087 0.0198 0.0606
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0248 0.1112
Brugia malayi FAT domain containing protein 0.014 0.034 0.1597
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0142 0.061
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0322 0.1463
Trypanosoma brucei protein kinase, putative 0.005 0.0096 0.0797
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0013 0.0013
Toxoplasma gondii target of rapamycin (TOR), putative 0.0382 0.0995 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0031 0.0047 0.0046
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0405 0.1055 0.1055
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0248 0.0855
Brugia malayi hypoxia-induced factor 1 0.0147 0.0358 0.1682
Echinococcus multilocularis Zinc finger, PHD finger 0.0175 0.0435 0.0434
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.004 0.0127
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0059 0.0217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0505 0.1742
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.052 0.2398
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0466 0.2142
Echinococcus multilocularis survival motor neuron protein 1 0.0459 0.1201 0.1201
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.004 0.004
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.0466 0.1259
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0046 0.0087 0.0349
Echinococcus multilocularis lamin dm0 0.0026 0.0033 0.0033
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.004 0.004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Echinococcus granulosus expressed conserved protein 0.0079 0.0177 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0677 0.314
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0064 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0346 0.0898 0.4182
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0099 0.0407
Brugia malayi PXA domain containing protein 0.002 0.0016 0.0077
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0197 0.0601
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0038
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0022 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.0087 0.0198 0.0684
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.004 0.0127
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0013 0.0013
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0013 0.0026
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0248 0.1112
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0087 0.0198 0.1978
Loa Loa (eye worm) phosphatidylinositol 3 0.0087 0.0198 0.0684
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0046 0.0087 0.024
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0175 0.0435 0.0434
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0059 0.0217
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0175 0.0435 0.1992
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0013 0.0038
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.057 0.1501 0.1501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0946 0.441
Plasmodium vivax unspecified product 0.0133 0.0322 0.7161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0242 0.0617 0.2854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0119 0.0284 0.1283
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0018 0.0018
Brugia malayi follicle stimulating hormone receptor 0.023 0.0584 0.2741
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0357 0.0926 0.8763
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0197 0.0197
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0087 0.0198 0.0565
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0013 0.0044
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0221 0.0559 0.5236
Giardia lamblia Kinase, CMGC GSK 0.005 0.0096 0.0497
Brugia malayi Cytochrome P450 family protein 0.0019 0.0013 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0198 0.0877
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0013 0.0013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0046 0.0087 0.0351
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.000009784 0.0000000098062
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0087 0.0198 0.0565
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.004 0.004
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.019 0.019
Leishmania major phosphatidylinositol 3-kinase, putative 0.0346 0.0898 0.2436
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1226 0.3276 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0221 0.0559 0.2624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0387 0.1007 0.4696
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0096 0.0332
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0013 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0466 0.2142
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0175 0.0435 0.1992
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.005 0.0096 0.0949
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.004 0.0127
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0 0.0001
Onchocerca volvulus 0.005 0.0096 0.1193
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0057 0.0173
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0079 0.0177 0.0775
Echinococcus multilocularis serine protein kinase ATM 0.0221 0.0559 0.0559
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0013 0.006
Echinococcus multilocularis protein kinase shaggy 0.005 0.0096 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0142 0.061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.004 0.0122
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0087 0.0198 0.0877
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0079 0.0177 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0995 0.4638
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0096 0.0395
Loa Loa (eye worm) phosphatidylinositol 3 0.0405 0.1055 0.3637
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0022 0.0066
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0087 0.0198 0.4423
Brugia malayi hypothetical protein 0.0019 0.0013 0.006
Echinococcus granulosus tumor protein p63 0.0329 0.0851 0.0851
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0215 0.1009
Entamoeba histolytica casein kinase, putative 0.0133 0.0322 0.1463
Schistosoma mansoni casein kinase II beta subunit 0.0036 0.0059 0.0179
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0131 0.0318 0.1491
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0175 0.0435 0.1253
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0173
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0018 0.0084
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0087 0.0198 0.0198
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.004 0.0383
Loa Loa (eye worm) hypothetical protein 0.0331 0.0856 0.295
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0044
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0013 0.0013
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0156 0.0156
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0022 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0248 0.1112
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0013 0.0038
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0395 0.103 0.103
Schistosoma mansoni intermediate filament proteins 0.0026 0.0033 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0947 0.4411
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0248 0.1112
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0047 0.0046
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.014 0.034 0.034
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0405 0.1055 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0313 0.0807 0.3788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0346 0.0898 0.4182
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0079 0.0177 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0466 0.2142
Entamoeba histolytica hypothetical protein 0.0087 0.0198 0.0877
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0313 0.0808 0.3758
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0057 0.0057
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0313 0.0807 1
Trichomonas vaginalis conserved hypothetical protein 0.0227 0.0576 0.2662
Loa Loa (eye worm) hypothetical protein 0.0159 0.0391 0.1349
Loa Loa (eye worm) hypothetical protein 0.0131 0.0318 0.1094
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0248 1
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0046 0.0088 0.0302
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0405 0.1055 0.3222
Brugia malayi Serotonin receptor 0.0454 0.1189 0.558
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0099 0.0407
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0079 0.0177 0.1569
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.014 0.034 0.034
Entamoeba histolytica hypothetical protein 0.0664 0.1756 0.8234
Echinococcus multilocularis casein kinase ii subunit alpha 0.0133 0.0322 0.0322
Leishmania major cytochrome p450-like protein 0.0019 0.0013 0.0024
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0357 0.0928 0.4322
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0046 0.0087 0.0087
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0033 0.0153
Brugia malayi intracellular kinase 0.005 0.0096 0.0452
Schistosoma mansoni hypothetical protein 0.0087 0.0198 0.0606
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0802 0.213 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0013 0.0013
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0087 0.0198 0.4023
Echinococcus granulosus intermediate filament protein 0.0026 0.0033 0.0033
Toxoplasma gondii GAF domain-containing protein 0.0033 0.0052 0.0506
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0175 0.0435 0.1992
Entamoeba histolytica hypothetical protein 0.0087 0.0198 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0242 0.0617 0.2854
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0466 0.2142
Onchocerca volvulus 0.0229 0.0581 0.7198
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0215 0.0958
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0036 0.0059 0.0435
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0175 0.0435 0.1497
Echinococcus granulosus high voltage activated calcium channel beta 0.0084 0.019 0.019
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.009 0.0275
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0013 0.0038
Onchocerca volvulus 0.0026 0.0033 0.0404
Giardia lamblia Kinase, CMGC CK2 0.0133 0.0322 0.2474
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.059 0.1557 0.7293
Brugia malayi hypothetical protein 0.0035 0.0057 0.0267
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.0466 0.5778
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0087 0.0198 0.0606
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0087 0.0198 0.0877
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0466 0.1346
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0031 0.0047 0.0046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0802 0.213 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0559 0.258
Brugia malayi intermediate filament protein 0.0026 0.0033 0.0153
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0346 0.0898 0.8493
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0087 0.0198 0.1978
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.005 0.0096 0.0294
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0123 0.0295 0.2703
Onchocerca volvulus 0.0087 0.0198 0.2458
Loa Loa (eye worm) phosphatidylinositol 3 0.0087 0.0198 0.0684
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Echinococcus multilocularis 0.0087 0.0198 0.0198
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0131 0.0318 0.0969
Schistosoma mansoni single-minded 0.0047 0.009 0.0275
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.0466 0.2189
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0087 0.0198 0.0565
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0013 0.0044
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0175 0.0435 0.4356
Schistosoma mansoni fkbp-rapamycin associated protein 0.0207 0.052 0.1589
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0387 0.1007 0.2733
Toxoplasma gondii hypothetical protein 0.0033 0.0052 0.0506
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0022 0.0021
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0071 0.0154 0.6005
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.0227 0.1064
Leishmania major hypothetical protein, conserved 0.1374 0.3673 1
Brugia malayi hypothetical protein 0.0019 0.0013 0.006
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0248 0.0248
Brugia malayi Pre-SET motif family protein 0.0201 0.0505 0.2373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0995 0.4638
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0175 0.0435 0.1172
Leishmania major hypothetical protein, conserved 0.0038 0.0064 0.0163
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0175 0.0435 0.204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0947 0.4411
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0174 0.0432 0.149
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0016 0.0057
Echinococcus multilocularis lamin 0.0026 0.0033 0.0033
Onchocerca volvulus 0.0098 0.0227 0.2808
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0313 0.0807 0.2781
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0156 0.0156
Onchocerca volvulus 0.0048 0.0092 0.1143
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0322 0.1463
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0313 0.0807 0.0807
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0059 0.0725
Loa Loa (eye worm) hypothetical protein 0.0207 0.052 0.1793
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.000009784 0.000000029939
Brugia malayi hypothetical protein 0.0098 0.0227 0.1065
Echinococcus granulosus casein kinase ii subunit beta 0.0036 0.0059 0.0059
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0087 0.0198 0.1777
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.004 0.0122
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0013 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0175 0.0435 0.4356
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.004 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0046 0.0087 0.0409
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1226 0.3276 0.3275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.004 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0387 0.1007 0.4696
Schistosoma mansoni hypothetical protein 0.0094 0.0215 0.0656
Loa Loa (eye worm) phosphatidylinositol 3 0.0226 0.0572 0.1972
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0057 0.0267
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0006 0.0019
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0217 0.0549 0.2531
Echinococcus granulosus protein kinase shaggy 0.005 0.0096 0.0096
Echinococcus granulosus voltage dependent calcium channel 0.0031 0.0047 0.0046
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.057 0.1501 0.1501
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0245 0.0625 0.5867
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0248 1
Trichomonas vaginalis set domain proteins, putative 0.0229 0.0581 0.2682
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0064 0.0174
Loa Loa (eye worm) phosphatidylinositol 3 0.1088 0.2902 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0013 0.0038
Schistosoma mansoni hypothetical protein 0.005 0.0097 0.0297
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.005 0.0096 0.0268
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0248 1
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0059 0.0484
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0207 0.052 0.052
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0071 0.0154 0.5206
Brugia malayi hypothetical protein 0.0159 0.0391 0.1838
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0036
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0038
Loa Loa (eye worm) phosphatidylinositol kinase 0.0087 0.0198 0.0684
Loa Loa (eye worm) gastrulation defective protein 1 0.0127 0.0305 0.1052
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0322 0.1463
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.004 0.0376
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0466 0.2142
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0036 0.0059 0.0725
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0013 0.0013
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0087 0.0198 0.1978
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.0466 0.0466
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0314 0.0959
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0248 0.0757
Entamoeba histolytica protein kinase, putative 0.005 0.0096 0.0395
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.004 0.0127
Leishmania major phosphatidylinositol kinase related protein, putative 0.0102 0.0237 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.0629 0.2911
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0013 0.006
Mycobacterium leprae conserved hypothetical protein 0.0087 0.0198 0.7463
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0046 0.0087 0.0087
Mycobacterium tuberculosis Conserved hypothetical protein 0.0087 0.0198 0.7463
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3716 1 1
Trichomonas vaginalis conserved hypothetical protein 0.014 0.034 0.1546
Brugia malayi Cytochrome P450 family protein 0.0029 0.004 0.019
Echinococcus granulosus cyclin dependent kinase 19 0.013 0.0314 0.0314
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0405 0.1055 0.1055
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.0209
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.004 0.0127
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0715 0.1894 0.8885
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0092 0.0282
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Entamoeba histolytica protein kinase domain containing protein 0.0133 0.0322 0.1463
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0046 0.0087 0.0349
Schistosoma mansoni voltage-gated cation channel 0.0031 0.0047 0.0142
Loa Loa (eye worm) phosphatidylinositol 3 0.0087 0.0198 0.0684
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0248 0.2254
Plasmodium vivax hypothetical protein 0.0087 0.0198 0.4023
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0175 0.0435 0.0434
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0175 0.0435 0.1326
Loa Loa (eye worm) hypothetical protein 0.057 0.1501 0.5172
Echinococcus granulosus lamin dm0 0.0026 0.0033 0.0033
Echinococcus granulosus bloom syndrome protein 0.0021 0.0018 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.004 0.0139
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0313 0.0808 0.3758
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.004 0.0127
Loa Loa (eye worm) Csnk2b protein 0.0036 0.0059 0.0202
Schistosoma mansoni hypothetical protein 0.0164 0.0405 0.1235
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0057 0.0057
Toxoplasma gondii hypothetical protein 0.0033 0.0052 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0346 0.0898 0.4182
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0013 0.0013
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Plasmodium falciparum casein kinase II beta chain 0.0036 0.0059 0.112
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0175 0.0435 0.1326
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.0466 0.1607
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0033 0.0113
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.004 0.0127
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0087 0.0198 0.0198
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0079 0.0177 0.0775
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0133 0.0323 0.0927
Echinococcus multilocularis expressed conserved protein 0.0079 0.0177 0.0177
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0313 0.0807 0.0807
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0064 0.0606
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.000009784 0.0000000098062
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0313 0.0808 0.3758
Echinococcus multilocularis cyclin dependent kinase 19 0.013 0.0314 0.0314
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0802 0.213 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0031 0.0047 0.0142
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0424 0.1108 0.5201
Loa Loa (eye worm) calcium channel 0.0031 0.0047 0.0161
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0087 0.0198 0.0877
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0175 0.0435 0.1992
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0087 0.0198 0.0198
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0108
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0117 0.0279 0.1256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0044
Loa Loa (eye worm) hypothetical protein 0.0098 0.0227 0.0782
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0044
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0133 0.0322 0.7161
Entamoeba histolytica hypothetical protein 0.0087 0.0198 0.0877
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0087 0.0198 0.1777
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0036 0.0059 0.0158
Brugia malayi Cytochrome P450 family protein 0.0019 0.0013 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0322 0.1463
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0079 0.0177 0.0775
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0096 0.0395
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0995 0.4638
Brugia malayi Protein kinase domain containing protein 0.0017 0.0009 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.0466 0.1423
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0013 0.0038
Schistosoma mansoni lamin 0.0026 0.0033 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.0198 0.0932
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0022 0.0074
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0387 0.1007 0.9538
Loa Loa (eye worm) phosphatidylinositol 3 0.0357 0.0926 0.3193
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0405 0.1055 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.1055 0.4924
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0175 0.0435 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0087 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0133 0.0323 0.1112
Brugia malayi PAS domain containing protein 0.0047 0.009 0.0423
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0079 0.0177 0.0502
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.0064 0.0489
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0452 0.1183 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0313 0.0808 0.3758
Brugia malayi PXA domain containing protein 0.002 0.0016 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.0959 0.4468
Loa Loa (eye worm) hypothetical protein 0.0459 0.1201 0.414
Giardia lamblia GTOR 0.0405 0.1055 0.8883
Brugia malayi Protein kinase domain containing protein 0.0313 0.0807 0.3788
Loa Loa (eye worm) hypothetical protein 0.014 0.034 0.1172
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0207 0.052 0.1503
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0572 0.1507 0.7075
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0079 0.0177 0.0775
Entamoeba histolytica hypothetical protein 0.0221 0.0559 0.258
Giardia lamblia Kinase, CMGC GSK 0.005 0.0096 0.0497
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0139
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0664 0.1756 0.8234
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0052 0.1665
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0013 0.0046
Entamoeba histolytica protein kinase rad3, putative 0.0207 0.052 0.2398
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0133 0.0322 0.1111
Loa Loa (eye worm) hypothetical protein 0.0031 0.0047 0.0161
Giardia lamblia Kinase, PLK 0.0187 0.0466 0.3732
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.0807 0.2463
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0197 0.0601
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0466 0.2142
Leishmania major phosphatidylinositol 4-kinase, putative 0.0087 0.0198 0.0529
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0079 0.0177 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0946 0.441
Schistosoma mansoni kinase 0.0096 0.0222 0.0678
Onchocerca volvulus 0.0094 0.0215 0.2664
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Onchocerca volvulus 0.0087 0.0198 0.2458
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0322 0.1463
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Onchocerca volvulus 0.0098 0.0227 0.2808
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0313 0.0808 0.3795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0995 0.4638
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0248 0.1112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0052 0.018
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0685 0.3175
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0018 0.0025
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0079 0.0177 0.1569
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1226 0.3276 0.3275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0947 0.4411
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0022 0.0101
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0395 0.103 0.3146
Echinococcus multilocularis expressed protein 0.0363 0.0944 0.0944
Leishmania major phosphatidylinositol 3-kinase, putative 0.0175 0.0435 0.1172
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0215 0.0958
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0079 0.0177 0.0502
Loa Loa (eye worm) hypothetical protein 0.0087 0.0198 0.0684
Brugia malayi 6-phosphofructokinase 0.0106 0.0248 0.1165
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0117 0.0279 0.1256
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.013 0.0314 0.1082
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0036 0.0059 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.0466 0.2142
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.0584 0.2012
Echinococcus granulosus casein kinase ii subunit alpha 0.0133 0.0322 0.0322
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0079 0.0177 0.0177
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0198 0.4023
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0031 0.0047 0.0142
Entamoeba histolytica hypothetical protein 0.0035 0.0057 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0995 0.4638
Leishmania major casein kinase II, putative 0.0133 0.0322 0.0867
Plasmodium vivax glycogen synthase kinase 3, putative 0.005 0.0096 0.1438
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.004 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0387 0.1007 0.4696
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0031 0.0047 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0226 0.0572 0.1654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0405 0.1055 0.4954
Toxoplasma gondii CMGC kinase, CK2 family 0.0133 0.0322 0.3226
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0175 0.0435 1
Brugia malayi Pre-SET motif family protein 0.0029 0.004 0.0189
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0037 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0133 0.0322 0.1463
Loa Loa (eye worm) hypothetical protein 0.0277 0.0711 0.245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0405 0.1055 0.4924
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Brugia malayi SH2 domain containing protein 0.0331 0.0856 0.4019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.0198 0.0932
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0175 0.0435 0.4043
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0036 0.0059 0.0148
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0248 0.0855
Loa Loa (eye worm) hypothetical protein 0.0048 0.0092 0.0318
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0357 0.0926 0.2513
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0313 0.0807 0.2781
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0087 0.0198 0.4023
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.2094 0.2094
Schistosoma mansoni hypothetical protein 0.014 0.034 0.1038
Brugia malayi Protein kinase domain containing protein 0.013 0.0314 0.1474
Giardia lamblia Phosphatidylinositol 4-kinase 0.0087 0.0198 0.139
Plasmodium falciparum glycogen synthase kinase 3 0.005 0.0096 0.201
Brugia malayi hypothetical protein 0.0459 0.1201 0.5639
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0031 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0044
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0175 0.0435 0.1253
Echinococcus multilocularis musashi 0.0026 0.0033 0.0033
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0248 0.0855
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0248 0.1112
Trypanosoma brucei Casein kinase II 0.0133 0.0322 0.2966
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0084 0.019 0.019
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0079 0.0177 0.0775
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0087 0.0198 0.0198
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0079 0.0177 0.0502
Echinococcus multilocularis casein kinase ii subunit beta 0.0036 0.0059 0.0059
Echinococcus multilocularis voltage dependent calcium channel 0.0031 0.0047 0.0046
Brugia malayi 6-phosphofructokinase 0.0106 0.0248 0.1165
Toxoplasma gondii ck2 beta subunit 0.0036 0.0059 0.0569
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0036 0.0059 0.0569
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0802 0.213 0.6192
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0052 0.0325
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0013 0.0013
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0031 0.0047 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0364 0.0946 0.441
Echinococcus multilocularis tumor protein p63 0.0329 0.0851 0.0851
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0087 0.0198 0.0932
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0284 0.1283
Leishmania major phosphatidylinositol kinase, putative 0.0087 0.0198 0.0529
Echinococcus granulosus glycogen synthase kinase 3 beta 0.005 0.0096 0.0096
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0057 0.1861
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0405 0.1055 0.3061
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.004 0.0376
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0405 0.1055 0.2864
Leishmania major hypothetical protein, unknown function 0.0087 0.0198 0.0529
Echinococcus granulosus lamin 0.0026 0.0033 0.0033
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0395 0.103 0.2989
Echinococcus granulosus serine protein kinase ATM 0.0221 0.0559 0.0559
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0313 0.0808 0.763
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0802 0.213 0.6192
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0013 0.0013
Trypanosoma cruzi target of rapamycin kinase 3 0.0387 0.1007 0.2921
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0221 0.0559 0.1615
Schistosoma mansoni hypothetical protein 0.0079 0.0177 0.0539
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0087 0.0198 0.0565
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0013 0.0013
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.005 0.0096 0.025
Onchocerca volvulus 0.0035 0.0057 0.0705
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0395 0.103 0.103
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0248 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0221 0.0559 0.1706
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0087 0.0351
Trichomonas vaginalis casein kinase II beta chain, putative 0.0036 0.0059 0.0217
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0197 0.0197
Plasmodium falciparum GAF domain-related protein, putative 0.0033 0.0052 0.0972
Loa Loa (eye worm) CMGC/GSK protein kinase 0.005 0.0096 0.0332
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0802 0.213 1
Plasmodium vivax casein kinase II beta chain, putative 0.0036 0.0059 0.0484
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.0466 0.1346
Schistosoma mansoni survival motor neuron protein 0.0094 0.0215 0.0656
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0096 0.0395
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.004 0.0668
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0087 0.0198 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0087 0.0198 0.0877
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0142 0.061
Brugia malayi Casein kinase II, alpha chain 0.0133 0.0322 0.1513
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0013 0.006
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0013 0.0026
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0079 0.0177 0.0775
Echinococcus multilocularis geminin 0.0164 0.0405 0.0404
Schistosoma mansoni protein kinase 0.0133 0.0322 0.0984
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0087 0.0198 0.4023
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0013 0.0046
Echinococcus granulosus single minded 2 0.0035 0.0057 0.0057
Schistosoma mansoni lamin 0.0026 0.0033 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.007 0.0213

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 4 uM Effective concentration of compound required to protect C3H/3T3 embryo murine fibroblasts against the MSV induced transformation ChEMBL. 12801238
EC50 (functional) > 4 uM Effective concentration of compound required to protect C3H/3T3 embryo murine fibroblasts against the MSV induced transformation ChEMBL. 12801238
EC50 (functional) = 6 uM Effective concentration of compound required to protect human T-lymphocytic cells against the cytopathogenicity of HIV-1 ChEMBL. 12801238
EC50 (functional) = 12 uM Concentration required to protect human T-lymphocytic cells against the cytopathogenicity of HIV-2 ChEMBL. 12801238
IC50 (functional) = 70 uM Inhibitory concentration of compound against proliferation of murine lukemia cells L1210 was determined ChEMBL. 12801238
IC50 (functional) = 70 uM Inhibitory concentration of compound against proliferation of murine lukemia cells L1210 was determined ChEMBL. 12801238
IC50 (functional) > 100 uM Inhibitory concentration of compound against proliferation of human T-lymphocytic cells MOLT-4/C8 was determined ChEMBL. 12801238
IC50 (functional) > 100 uM Inhibitory concentration against proliferation of human T-lymphocytic (CEM) cells ChEMBL. 12801238
IC50 (functional) > 100 uM Inhibitory concentration of compound against proliferation of human T-lymphocytic cells MOLT-4/C8 was determined ChEMBL. 12801238
IC50 (functional) > 100 uM Inhibitory concentration against proliferation of human T-lymphocytic (CEM) cells ChEMBL. 12801238
MIC (functional) = 20 uM Minimal inhibitory concentration required to cause a microscopic detectable alteration of C3H/3T3 embryo murine fibroblast cell morphology ChEMBL. 12801238
MIC (functional) = 20 uM Minimal inhibitory concentration required to cause a microscopic detectable alteration of C3H/3T3 embryo murine fibroblast cell morphology ChEMBL. 12801238

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 12801238

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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