Detailed information for compound 401402

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 936.101 | Formula: C48H69N7O12
  • H donors: 9 H acceptors: 11 LogP: 4.28 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCCCCCOc1ccc(cc1)C(=O)NC1CCCNC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC1=O)[C@H](O)C)C[C@@H](C2)O)CCc1ccc(cc1)O)[C@H](O)C
  • InChi: 1S/C48H69N7O12/c1-4-5-6-7-8-9-26-67-35-21-17-32(18-22-35)42(60)50-36-12-10-24-49-45(63)38-13-11-25-54(38)47(65)40(29(2)56)52-44(62)37(23-16-31-14-19-33(58)20-15-31)51-46(64)39-27-34(59)28-55(39)48(66)41(30(3)57)53-43(36)61/h14-15,17-22,29-30,34,36-41,56-59H,4-13,16,23-28H2,1-3H3,(H,49,63)(H,50,60)(H,51,64)(H,52,62)(H,53,61)/t29-,30-,34-,36?,37+,38+,39+,40+,41+/m1/s1
  • InChiKey: GLOBUVDWOFNRFE-MXGNEDCWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Echinococcus multilocularis calpain 0.012 0.0251 0.0241
Schistosoma mansoni alpha-glucosidase 0.0327 0.0765 0.4207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0213 0.316
Onchocerca volvulus 0.0054 0.0087 0.0947
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0054 0.0087 0.1029
Leishmania major hypothetical protein, unknown function 0.0054 0.0087 0.0198
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0281 0.0652 0.3578
Giardia lamblia Phosphatidylinositol 4-kinase 0.0054 0.0087 0.1095
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) calpain 5 0.0084 0.0161 0.2102
Entamoeba histolytica grainin 2 0.0026 0.0018 0.0023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0177 0.0392 0.591
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Brugia malayi Glycosyl hydrolases family 31 protein 0.0047 0.0069 0.0784
Trichomonas vaginalis set domain proteins, putative 0.0256 0.0589 0.9012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma cruzi centrin, putative 0.0041 0.0053 0.0104
Echinococcus multilocularis Myosin regulatory light chain 0.0026 0.0018 0.0008
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0281 0.0652 0.0644
Trichomonas vaginalis calmodulin, putative 0.0041 0.0053 0.0685
Leishmania major phosphatidylinositol kinase, putative 0.0054 0.0087 0.0198
Echinococcus granulosus Myosin regulatory light chain 0.0026 0.0018 0.0008
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0123 0.0258 0.0249
Giardia lamblia Cathepsin B precursor 0.0095 0.0188 0.2685
Entamoeba histolytica casein kinase, putative 0.0198 0.0445 0.6739
Loa Loa (eye worm) phosphatidylinositol kinase 0.0054 0.0087 0.1138
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.013
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0281 0.0652 0.1841
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0281 0.0652 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Echinococcus granulosus microtubule associated protein 2 0.0746 0.1807 0.1799
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.1957
Trypanosoma brucei caltractin, putative 0.0041 0.0053 0.0579
Schistosoma mansoni calpain-7 (C02 family) 0.012 0.0251 0.1342
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0087 0.0433
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0033 0.0237
Leishmania major kinesin, putative 0.0084 0.0161 0.0404
Giardia lamblia Hypothetical protein 0.0054 0.0087 0.1095
Plasmodium vivax unspecified product 0.0198 0.0445 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0281 0.0652 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.0512 0.6684
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.1115
Schistosoma mansoni myosin light chain 0.0026 0.0018 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Plasmodium vivax hypothetical protein 0.0054 0.0087 0.1957
Trichomonas vaginalis calcium binding protein, putative 0.0041 0.0053 0.0685
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0054 0.0087 0.111
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.1957
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Entamoeba histolytica protein kinase rad3, putative 0.0159 0.0347 0.5203
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Trypanosoma brucei kinesin, putative 0.0084 0.0161 0.2271
Echinococcus granulosus lysosomal alpha glucosidase 0.0327 0.0765 0.0757
Brugia malayi Probable myosin regulatory light chain 0.0026 0.0018 0.0109
Trichomonas vaginalis calmodulin, putative 0.0026 0.0018 0.0129
Echinococcus granulosus serine protein kinase ATM 0.0159 0.0347 0.0338
Trypanosoma brucei Calpain-like protein 2 0.0036 0.0042 0.0402
Entamoeba histolytica calmodulin, putative 0.0026 0.0018 0.0023
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0054 0.0087 0.1957
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Leishmania major casein kinase II, putative 0.0198 0.0445 0.1196
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0159 0.0347 0.0956
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0229
Loa Loa (eye worm) phosphatidylinositol 3 0.0281 0.0652 0.8524
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0287 0.0666 0.3655
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.023 0.0524 0.6852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0105 0.0213 0.0565
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0825
Loa Loa (eye worm) calpain family protein 1 0.0318 0.0743 0.9705
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0159 0.0347 0.0956
Leishmania major glycosyl hydrolase-like protein 0.0047 0.0069 0.0146
Brugia malayi calpain 7 0.012 0.0251 0.3191
Entamoeba histolytica protein kinase, putative 0.0087 0.0168 0.2389
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0054 0.0087 0.0433
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Echinococcus granulosus programmed cell death protein 6 0.0026 0.0018 0.0008
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.2472
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.009
Trypanosoma cruzi conserved protein 0.0036 0.0042 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0825
Leishmania major phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.0198
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0258 0.3861
Schistosoma mansoni hypothetical protein 0.0054 0.0087 0.0433
Echinococcus multilocularis calpain A 0.0332 0.0779 0.077
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0402
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.013
Plasmodium falciparum calpain 0.0036 0.0042 0.0945
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0392 0.5955
Entamoeba histolytica hypothetical protein 0.0159 0.0347 0.5203
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0332 0.0779 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.0534 0.698
Trypanosoma brucei Calpain-like protein 1.1 0.0036 0.0042 0.0402
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0026 0.0018 0.0019
Trypanosoma cruzi centrin-3 0.0041 0.0053 0.0104
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0054 0.0087 0.1957
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Echinococcus multilocularis cathepsin b 0.0287 0.0666 0.0658
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0159 0.0347 0.4469
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 0.1841
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0426
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0016 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) calpain family protein 1 0.0234 0.0534 0.698
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0016 0.1849
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0054 0.0087 0.121
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.0198
Echinococcus multilocularis programmed cell death protein 0.0041 0.0053 0.0044
Trichomonas vaginalis calpain, putative 0.0036 0.0042 0.0509
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.021
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0087 0.1957
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0069 0.0148
Schistosoma mansoni alpha glucosidase 0.0047 0.0069 0.033
Schistosoma mansoni eyes absent homolog 0.0095 0.0189 0.1001
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.009
Onchocerca volvulus 0.0327 0.0765 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.121
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0287 0.0666 0.1881
Loa Loa (eye worm) calpain D 0.0036 0.0042 0.0549
Trichomonas vaginalis caltractin, putative 0.0026 0.0018 0.0129
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0087 0.121
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0087 0.121
Echinococcus multilocularis calpain 7 (C02 family) 0.012 0.0251 0.0241
Echinococcus granulosus calpain 7 C02 family 0.012 0.0251 0.0241
Brugia malayi calpain family protein 1 0.0318 0.0743 0.9701
Echinococcus granulosus calpain 5 0.012 0.0251 0.0241
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0198 0.0445 0.5812
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Loa Loa (eye worm) myosin Light Chain family member 0.0026 0.0018 0.0229
Toxoplasma gondii cathepsin B 0.0095 0.0188 0.2685
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.111
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Brugia malayi hypothetical protein 0.0095 0.0189 0.2379
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.404 1 1
Onchocerca volvulus 0.0054 0.0087 0.0947
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0129
Trichomonas vaginalis calpain, putative 0.0036 0.0042 0.0509
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Trichomonas vaginalis sucrase-isomaltase, putative 0.0047 0.0069 0.0922
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.0765 0.0757
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0229
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trypanosoma brucei glycosyl hydrolase-like protein 0.0047 0.0069 0.0819
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0016 0.1849
Loa Loa (eye worm) hypothetical protein 0.0282 0.0653 0.8534
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0273 0.3569
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0054 0.0087 0.1095
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0016 1
Trypanosoma brucei cysteine peptidase, putative 0.0036 0.0042 0.0402
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0054 0.0087 0.0078
Echinococcus granulosus calcyphosin protein 0.0026 0.0018 0.0008
Toxoplasma gondii hypothetical protein 0.0036 0.0042 0.0386
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Echinococcus multilocularis serine protein kinase ATM 0.0159 0.0347 0.0338
Giardia lamblia Cathepsin B precursor 0.0095 0.0188 0.2685
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0087 1
Echinococcus granulosus calpain A 0.0332 0.0779 0.077
Trichomonas vaginalis calpain, putative 0.0036 0.0042 0.0509
Entamoeba histolytica protein kinase domain containing protein 0.0198 0.0445 0.6739
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.021
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0054 0.0087 0.0078
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0036 0.0042 0.0402
Leishmania major calpain family cysteine protease-like protein 0.0036 0.0042 0.0072
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Echinococcus multilocularis programmed cell death protein 6 0.0026 0.0018 0.0008
Schistosoma mansoni protein kinase 0.0198 0.0445 0.2424
Loa Loa (eye worm) hypothetical protein 0.0054 0.0087 0.1138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0402
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0318 0.0743 0.4081
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0159 0.0347 0.188
Echinococcus multilocularis microtubule associated protein 2 0.0746 0.1807 0.1799
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0654
Loa Loa (eye worm) hypothetical protein 0.0177 0.0392 0.5125
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0054 0.0087 0.1957
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0016 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0281 0.0652 0.8524
Trypanosoma brucei centrin-3 0.0041 0.0053 0.0579
Trichomonas vaginalis hypothetical protein 0.0036 0.0042 0.0509
Leishmania major calpain protease-like protein 0.0036 0.0042 0.0072
Brugia malayi Pre-SET motif family protein 0.0225 0.0512 0.6644
Brugia malayi cathepsin B-like cysteine proteinase 0.0287 0.0666 0.8689
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0281 0.0652 0.0644
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0281 0.0652 0.0644
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0054 0.0087 0.0078
Echinococcus multilocularis hypothetical protein 0.012 0.0251 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0188 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0402
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0281 0.0652 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0087 0.121
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Echinococcus multilocularis Calcium binding protein 0.0026 0.0018 0.0008
Brugia malayi MH2 domain containing protein 0.0129 0.0273 0.349
Mycobacterium leprae conserved hypothetical protein 0.0054 0.0087 1
Trypanosoma brucei calpain, putative 0.0036 0.0042 0.0402
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0087 0.0433
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.0202
Echinococcus multilocularis 0.0054 0.0087 0.0078
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0054 0.0087 0.121
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.003 0.002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.0666 0.3655
Echinococcus multilocularis calcyphosin protein 0.0026 0.0018 0.0008
Onchocerca volvulus 0.0026 0.0018 0.0019
Trichomonas vaginalis kakapo, putative 0.0026 0.0018 0.0129
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0054 0.0087 0.0433
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Entamoeba histolytica hypothetical protein 0.0054 0.0087 0.1115
Plasmodium falciparum casein kinase 2, alpha subunit 0.0198 0.0445 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Echinococcus granulosus neutral alpha glucosidase AB 0.0047 0.0069 0.0059
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0332 0.0779 0.428
Schistosoma mansoni calpain-7 (C02 family) 0.012 0.0251 0.1342
Plasmodium vivax calpain, putative 0.012 0.0251 0.5632
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0071
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0804
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Entamoeba histolytica calpain large subunit domain III containing protein 0.0084 0.0161 0.2276
Mycobacterium ulcerans hypothetical protein 0.0026 0.0016 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0877
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0026 0.0018 0.0129
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Trypanosoma cruzi centrin, putative 0.0041 0.0053 0.0104
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Echinococcus multilocularis programmed cell death protein 0.0041 0.0053 0.0044
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0281 0.0652 0.1775
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0054 0.0087 0.1138
Trypanosoma brucei antigen, putative 0.012 0.0251 0.3681
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Toxoplasma gondii CMGC kinase, CK2 family 0.0198 0.0445 0.6731
Trichomonas vaginalis caltractin, putative 0.0026 0.0018 0.0129
Loa Loa (eye worm) hypothetical protein 0.0287 0.0666 0.8705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Onchocerca volvulus 0.023 0.0524 0.6785
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0095 0.0188 0.0494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) myosin regulatory light chain 1 0.0026 0.0018 0.0229
Trypanosoma cruzi casein kinase II, putative 0.0198 0.0445 0.1239
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0087 0.0202
Entamoeba histolytica grainin 2 0.0041 0.0053 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0281 0.0652 0.1775
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0047 0.0069 0.0148
Echinococcus multilocularis Zinc finger, PHD finger 0.0054 0.0087 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.111
Echinococcus granulosus calpain A 0.012 0.0251 0.0241
Trichomonas vaginalis centrin, putative 0.0026 0.0018 0.0129
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0087 0.0078
Brugia malayi Pre-SET motif family protein 0.0032 0.0033 0.0309
Schistosoma mansoni calpain-2 (C02 family) 0.0036 0.0042 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0016 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0054 0.0087 0.1957
Trypanosoma brucei Calpain-like protein 1.2 0.0036 0.0042 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0281 0.0652 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0054 0.0087 0.0202
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0087 0.0202
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.2472
Onchocerca volvulus 0.0256 0.0589 0.7644
Trichomonas vaginalis centrin, putative 0.0026 0.0018 0.0129
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Schistosoma mansoni hypothetical protein 0.0036 0.0042 0.0182
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0177 0.0392 0.5903
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trichomonas vaginalis maltase-glucoamylase, putative 0.0047 0.0069 0.0922
Loa Loa (eye worm) hypothetical protein 0.0159 0.0347 0.4536
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0654
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Toxoplasma gondii FATC domain-containing protein 0.0159 0.0347 0.5192
Trypanosoma cruzi target of rapamycin kinase 3 0.0281 0.0652 0.1841
Schistosoma mansoni microtubule-associated protein tau 0.0746 0.1807 1
Trypanosoma brucei Calpain-like protein CALP1.3 0.0036 0.0042 0.0402
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0281 0.0652 0.3578
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0047 0.0069 0.0148
Trypanosoma brucei glucosidase, putative 0.0047 0.0069 0.0819
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0071
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Loa Loa (eye worm) cathepsin B 0.0095 0.0188 0.2456
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0036 0.0042 0.0386
Leishmania major hypothetical protein, unknown function 0.0036 0.0042 0.0072
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Schistosoma mansoni fkbp-rapamycin associated protein 0.0159 0.0347 0.188
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Loa Loa (eye worm) calpain 0.012 0.0251 0.3273
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 1
Brugia malayi calpain 5 0.0036 0.0042 0.0433
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0281 0.0652 1
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0087 0.121
Echinococcus multilocularis calpain family protein 1, d 0.0234 0.0534 0.0525
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0159 0.0347 0.4469
Brugia malayi Neuronal calcium sensor family protein 1 0.0026 0.0018 0.0109
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0281 0.0652 0.1775
Schistosoma mansoni Mername-AA248 (C02 family) 0.012 0.0251 0.1342
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0087 0.121
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0159 0.0347 0.0338
Leishmania major hypothetical protein, conserved 0.1467 0.3601 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.0202
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0054 0.0087 0.0433
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0402
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.111
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Leishmania major phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.0198
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0054 0.0087 0.0078
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0033 0.0023
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0054 0.0087 0.0202
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0047 0.0069 0.0825
Schistosoma mansoni hypothetical protein 0.0123 0.0258 0.1382
Trichomonas vaginalis calcium binding protein, putative 0.0026 0.0018 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0054 0.0087 0.0202
Trichomonas vaginalis centrin, putative 0.0026 0.0018 0.0129
Schistosoma mansoni calpain (C02 family) 0.012 0.0251 0.1342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Brugia malayi Glycosyl hydrolases family 31 protein 0.0327 0.0765 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0054 0.0087 0.1095
Leishmania major hypothetical protein, conserved 0.0036 0.0042 0.0072
Leishmania major alpha glucosidase II subunit, putative 0.0047 0.0069 0.0146
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0033 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.3681
Schistosoma mansoni alpha-glucosidase 0.0327 0.0765 0.4207
Trypanosoma cruzi kinesin, putative 0.0084 0.0161 0.0416
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0026 0.0018 0.0019
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0054 0.0087 0.0078
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0332 0.0779 0.077
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0054 0.0087 0.0202
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0896
Trichomonas vaginalis CMGC family protein kinase 0.0198 0.0445 0.6773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Trypanosoma brucei Casein kinase II 0.0198 0.0445 0.6737
Echinococcus multilocularis calpain 5 0.012 0.0251 0.0241
Echinococcus multilocularis neutral alpha glucosidase AB 0.0047 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0105 0.0213 0.2777
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Trypanosoma brucei hypothetical protein 0.0036 0.0042 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Entamoeba histolytica calpain family cysteine protease, putative 0.0036 0.0042 0.0407
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0054 0.0087 0.0078
Echinococcus multilocularis lysosomal alpha glucosidase 0.0327 0.0765 0.0757
Trypanosoma cruzi kinesin, putative 0.0084 0.0161 0.0416
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 0.1775
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Brugia malayi calpain 5 0.0084 0.0161 0.2005
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0159 0.0347 0.5203
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0087 0.0078
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0327 0.0765 1
Schistosoma mansoni calmodulin-related 0.0026 0.0018 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0069 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0087 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.0392 0.5955
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0036 0.0042 0.0071
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Onchocerca volvulus 0.0198 0.0445 0.5719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0047 0.0069 0.0896
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0026 0.0018 0.0395
Giardia lamblia Cathepsin B precursor 0.0095 0.0188 0.2685
Loa Loa (eye worm) hypothetical protein 0.0318 0.0743 0.9705
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0016 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Brugia malayi Myosin regulatory light chain 1 0.0026 0.0018 0.0109
Toxoplasma gondii target of rapamycin (TOR), putative 0.0281 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.0445 0.5809
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0281 0.0652 0.1841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Echinococcus granulosus Calcium binding protein 0.0026 0.0018 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.021
Plasmodium vivax SET domain protein, putative 0.0032 0.0033 0.0733
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0054 0.0087 0.1095
Schistosoma mansoni myosin regulatory light chain 0.0026 0.0018 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.0666 0.3655
Trypanosoma brucei calpain-like protein, putative 0.012 0.0251 0.3681
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Loa Loa (eye worm) hypothetical protein 0.0054 0.0087 0.1138
Onchocerca volvulus 0.0032 0.0033 0.022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0281 0.0652 0.1841
Trichomonas vaginalis maltase-glucoamylase, putative 0.0047 0.0069 0.0922
Trypanosoma brucei calpain, putative 0.0036 0.0042 0.0402
Trichomonas vaginalis alpha-glucosidase, putative 0.0047 0.0069 0.0922
Trypanosoma cruzi hypothetical protein, conserved 0.1413 0.3467 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0054 0.0087 0.121
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1115
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.0652 0.8506
Giardia lamblia Kinase, CMGC CK2 0.0198 0.0445 0.6731
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0123 0.0258 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Brugia malayi Glycosyl hydrolases family 31 protein 0.0047 0.0069 0.0784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0273 0.3569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0087 0.121
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0054 0.0087 0.1115
Echinococcus granulosus casein kinase ii subunit alpha 0.0198 0.0445 0.0436
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0095 0.0188 0.0479
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0198 0.0445 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0281 0.0652 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0159 0.0347 0.0338
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0054 0.0087 0.0433
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0047 0.0069 0.07
Leishmania major phosphatidylinositol 3-kinase, putative 0.0281 0.0652 0.1775
Leishmania major phosphatidylinositol kinase related protein, putative 0.0054 0.0087 0.0198
Brugia malayi calpain family protein 1 0.0318 0.0743 0.9701
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.0251 0.0654
Onchocerca volvulus 0.0026 0.0018 0.0019
Schistosoma mansoni calpain C (C02 family) 0.012 0.0251 0.1342
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0054 0.0087 0.0202
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0071
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0054 0.0087 0.0433
Giardia lamblia GTOR 0.0281 0.0652 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0047 0.0069 0.0922
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0549
Echinococcus multilocularis casein kinase ii subunit alpha 0.0198 0.0445 0.0436
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0036 0.0042 0.0509
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0087 0.1029
Loa Loa (eye worm) hypothetical protein 0.0123 0.0258 0.3366
Loa Loa (eye worm) hypothetical protein 0.0023 0.0009 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0033 0.013
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0036 0.0042 0.0071
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0 0.5
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.0251 0.3681
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0087 0.1138
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.0251 0.0676
Echinococcus granulosus cathepsin b 0.0287 0.0666 0.0658
Brugia malayi FAT domain containing protein 0.0123 0.0258 0.3284
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.0666 0.3655
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0036 0.0042 0.0071
Echinococcus granulosus programmed cell death protein 0.0041 0.0053 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0033 0.013
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0159 0.0347 0.52
Trichomonas vaginalis PIKK family atypical protein kinase 0.0159 0.0347 0.5254
Brugia malayi RasGEF domain containing protein 0.0026 0.0018 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0188 0.2779
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0054 0.0087 0.111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0087 0.121
Trypanosoma cruzi calpain cysteine peptidase, putative 0.012 0.0251 0.0676
Plasmodium falciparum centrin-4 0.0026 0.0018 0.0395
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0054 0.0087 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0016 0.0877
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0087 0.121
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0036 0.0042 0.0072
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.0652 0.8506
Echinococcus granulosus calpain 0.012 0.0251 0.0241
Schistosoma mansoni myosin regulatory light chain 0.0026 0.0018 0.0046
Brugia malayi Casein kinase II, alpha chain 0.0198 0.0445 0.5761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0652 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0016 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0054 0.0087 0.1115
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0281 0.0652 0.0644
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0054 0.0087 0.1957
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0332 0.0779 0.428
Brugia malayi calpain D 0.0036 0.0042 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0042 0.0509
Trypanosoma brucei cysteine peptidase C (CPC) 0.0095 0.0188 0.2697
Echinococcus multilocularis cathepsin b 0.0287 0.0666 0.0658
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0213 0.316
Echinococcus granulosus cathepsin b 0.0287 0.0666 0.0658

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM Concentration of the compound inhibiting Candida beta-1,3-glucan synthesis was determined in a Candida albicans cell culture ChEMBL. 1495015
MFC (functional) = 0.25 ug ml-1 Antifungal activity of the compound on Candida tropicalis MY101 ChEMBL. 1495015
MFC (functional) = 4 ug ml-1 Antifungal activity of the compound on Candida albicans MY1208. ChEMBL. 1495015
MFC (functional) = 4 ug ml-1 Antifungal activity of the compound on Candida albicans MY1028. ChEMBL. 1495015
MFC (functional) = 8 ug ml-1 Antifungal activity of the compound on Candida albicans MY1055. ChEMBL. 1495015
MFC (functional) = 8 ug ml-1 Antifungal activity of the compound on Candida parapsilosis MY1010 ChEMBL. 1495015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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