Detailed information for compound 402533

Basic information

Technical information
  • TDR Targets ID: 402533
  • Name: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-am ino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-ami nopropanoyl]amino]-4-methylpentanoyl]amino]-4 -methylsulfanylbutanoyl]amino]-4-hydroxy-4-ox obutanoyl]amino]hexanoyl]amino]-3-hydroxyprop anoyl]amino]-4-methylpentanoyl]amino]-3-(1H-i midazol-5-yl)propanoyl]amino]-3-methylbutanoi c acid
  • MW: 1013.21 | Formula: C44H76N12O13S
  • H donors: 14 H acceptors: 14 LogP: -5.45 Rotable bonds: 42
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)Cc1nc[nH]c1)CC(C)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)C)CC(C)C)CCSC)CC(=O)O
  • InChi: 1S/C44H76N12O13S/c1-22(2)15-29(51-36(60)25(7)46)39(63)50-28(12-14-70-8)38(62)54-32(18-34(58)59)41(65)49-27(11-9-10-13-45)37(61)55-33(20-57)43(67)52-30(16-23(3)4)40(64)53-31(17-26-19-47-21-48-26)42(66)56-35(24(5)6)44(68)69/h19,21-25,27-33,35,57H,9-18,20,45-46H2,1-8H3,(H,47,48)(H,49,65)(H,50,63)(H,51,60)(H,52,67)(H,53,64)(H,54,62)(H,55,61)(H,56,66)(H,58,59)(H,68,69)/t25-,27-,28-,29-,30-,31-,32-,33-,35-/m0/s1
  • InChiKey: UVGCBOSBUYHJPJ-OOXFPACXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-methyl-pentanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]hexanoyl]amino]-3-hydroxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methyl-butanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]-4-methyl-1-oxopentyl]amino]-4-(methylthio)-1-oxobutyl]amino]-4-hydroxy-1,4-dioxobutyl]amino]-1-oxohexyl]amino]-3-hydroxy-1-oxopropyl]amino]-4-methyl-1-oxopentyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropyl]amino]-3-methylbutanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-azanyl-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-azanylpropanoyl]amino]-4-methyl-pentanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]hexanoyl]amino]-3-hydroxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methyl-butanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-methyl-pentanoyl]amino]-4-(methylthio)butanoyl]amino]-4-hydroxy-4-keto-butanoyl]amino]hexanoyl]amino]-3-hydroxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methyl-butyric acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-hydroxy-4-oxobutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]amino]-3-methylbutanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-methyl-pentanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-4-hydroxy-4-oxo-butanoyl]amino]hexanoyl]amino]-3-hydroxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]amino]-3-methyl-butanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]-4-methyl-1-oxopentyl]amino]-4-(methylthio)-1-oxobutyl]amino]-4-hydroxy-1,4-dioxobutyl]amino]-1-oxohexyl]amino]-3-hydroxy-1-oxopropyl]amino]-4-methyl-1-oxopentyl]amino]-3-(3H-imidazol-4-yl)-1-oxopropyl]amino]-3-methylbutanoic acid
  • (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-(alanylamino)-4-methyl-pentanoyl]amino]-4-(methylthio)butanoyl]amino]-4-hydroxy-4-keto-butanoyl]amino]-6-amino-hexanoyl]amino]-3-hydroxy-propanoyl]amino]-4-methyl-pentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]amino]-3-methyl-butyric acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens major histocompatibility complex, class I, A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0089 0.0081 0.0448
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0504 0.0547 0.3019
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0006 0.0006
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0214 0.0222 0.06
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0041 0.0028 0.007
Entamoeba histolytica hypothetical protein 0.004 0.0027 0.0179
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0022 0.0022
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0019 0.0019
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Onchocerca volvulus 0.0107 0.0102 0.2662
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0019 0.0019
Echinococcus granulosus lamin dm0 0.003 0.0016 0.0015
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0081 0.064
Leishmania major phosphatidylinositol 4-kinase, putative 0.0166 0.0168 0.0453
Echinococcus multilocularis Zinc finger, PHD finger 0.0275 0.029 0.0289
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0001 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0222 0.1834
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0028 0.0186
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.107 0.118 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0089 0.0081 0.064
Brugia malayi Uncoordinated protein 44 0.0016 0 0.0001
Echinococcus granulosus serine protein kinase ATM 0.044 0.0475 0.0474
Echinococcus multilocularis 0.0166 0.0168 0.0167
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0451 0.0487 0.4127
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0018 0.0018
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0102 0.0864
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0222 0.1834
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0149 0.0149 0.0924
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0142
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0027 0.0027
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0036 0.0022 0.0022
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0793 0.087 0.087
Loa Loa (eye worm) hypothetical protein 0.0112 0.0108 0.0667
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0006 0.0033
Brugia malayi Csnk2b protein 0.0041 0.0028 0.0236
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Echinococcus multilocularis casein kinase ii subunit alpha 0.0153 0.0153 0.0153
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0166 0.0168 0.0167
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0153 0.1252
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0007 0.0012
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0166 0.0168 0.0925
Echinococcus multilocularis musashi 0.003 0.0016 0.0015
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0275 0.029 0.1598
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0006 0.0006
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0818 0.6916
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0006 0.0006
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0046 0.0252
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0006 0.0033
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0166 0.0168 0.5786
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0166 0.0168 0.5786
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0222 0.1834
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0782 0.0858 0.2469
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0127 0.0125 0.101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0847 0.716
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0563 0.0613 0.5193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0767 0.0841 0.7111
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.001 0.0056
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0118 0.073
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0008 0.0048
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0451 0.0487 0.1399
Giardia lamblia GTOR 0.0793 0.087 1
Loa Loa (eye worm) Csnk2b protein 0.0041 0.0028 0.0173
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0043 0.0236
Echinococcus multilocularis expressed protein 0.0416 0.0448 0.0448
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0019 0.0019
Toxoplasma gondii target of rapamycin (TOR), putative 0.0767 0.0841 1
Plasmodium vivax unspecified product 0.0153 0.0153 0.5286
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0041 0.03
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1633 0.1811 0.1811
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0118
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0275 0.029 0.0289
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0166 0.0168 0.5707
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.044 0.0475 0.1363
Brugia malayi Protein kinase domain containing protein 0.0358 0.0383 0.3245
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0793 0.087 0.2376
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0036 0.0022 0.0122
Onchocerca volvulus 0.0057 0.0046 0.1193
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0006 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0027 0.0027
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0028 0.0186
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0089 0.0081 0.064
Echinococcus granulosus single minded 2 0.004 0.0027 0.0027
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0046 0.0126
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0006 0.0051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0166 0.0168 0.1419
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0046 0.0284
Loa Loa (eye worm) phosphatidylinositol 3 0.1457 0.1613 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0424 0.0456 0.0456
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0028 0.0725
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Brugia malayi M-phase phosphoprotein, mpp8 0.0112 0.0108 0.091
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0275 0.029 0.0829
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0019 0.0473
Leishmania major phosphatidylinositol kinase related protein, putative 0.0182 0.0186 0.0503
Loa Loa (eye worm) hypothetical protein 0.0166 0.0168 0.1038
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0138 0.0137 0.1159
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0037
Echinococcus multilocularis casein kinase ii subunit beta 0.0041 0.0028 0.0028
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0075 0.0067 0.5383
Brugia malayi FAT domain containing protein 0.0303 0.0321 0.272
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0006 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0222 0.1834
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0046 0.0046
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0019 0.0108
Echinococcus granulosus casein kinase ii subunit alpha 0.0153 0.0153 0.0153
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0007 0.0039
Onchocerca volvulus 0.0166 0.0168 0.4373
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0166 0.0168 0.1867
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0275 0.029 0.2414
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0007 0.0039
Brugia malayi bHLH-PAS transcription factor 0.004 0.0027 0.0229
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Schistosoma mansoni single-minded 0.0054 0.0043 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0019 0.0108
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0904 0.0994 0.0994
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0793 0.087 0.7355
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0051 0.0039 0.0278
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0019 0.0108
Loa Loa (eye worm) phosphatidylinositol kinase 0.0166 0.0168 0.1038
Schistosoma mansoni hypothetical protein 0.0187 0.0192 0.1059
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0125 0.101
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.8948 1 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.0475 0.399
Loa Loa (eye worm) hypothetical protein 0.0138 0.0137 0.0848
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Onchocerca volvulus 0.0112 0.0108 0.2804
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0166 0.0168 0.1375
Echinococcus granulosus voltage dependent calcium channel 0.0036 0.0022 0.0022
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0051 0.0039 0.0039
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0127 0.0125 0.101
Brugia malayi hypothetical protein 0.0182 0.0186 0.1574
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.044 0.0475 0.5424
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0019 0.5
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0009 0.0008
Schistosoma mansoni lamin 0.003 0.0016 0.0085
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0793 0.087 0.2376
Trichomonas vaginalis conserved hypothetical protein 0.0258 0.0271 0.2256
Trichomonas vaginalis set domain proteins, putative 0.0262 0.0275 0.2293
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0016 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0166 0.0168 0.1419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0168 0.1375
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0222 0.1834
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0006 0.0033
Toxoplasma gondii hypothetical protein 0.0036 0.0023 0.0276
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0793 0.087 0.087
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0016 0.0001 0.0006
Trypanosoma brucei protein kinase, putative 0.0057 0.0046 0.0457
Schistosoma mansoni casein kinase II beta subunit 0.0041 0.0028 0.0153
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.107 0.118 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0036 0.0022 0.0187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0166 0.0168 0.1419
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.0028 0.0186
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0118 0.0317
Giardia lamblia Casein kinase II beta chain 0.0041 0.0028 0.0107
Schistosoma mansoni voltage-gated cation channel 0.0036 0.0022 0.0122
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0081 0.0228
Loa Loa (eye worm) phosphatidylinositol 3 0.0166 0.0168 0.1038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.009 0.009
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0046 0.0119
Mycobacterium ulcerans putative regulatory protein 0.004 0.0027 0.1861
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0118 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0166 0.0168 0.5786
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0099 0.0094 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0468 0.0507 0.4261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0738 0.0809 0.6834
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0036 0.0022 0.0022
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0006 0.0033
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0028 0.0074
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0772 0.0847 0.0847
Echinococcus multilocularis tumor protein p63 0.0377 0.0404 0.0404
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0118 0.0952
Brugia malayi intermediate filament protein 0.003 0.0016 0.0131
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0793 0.087 0.2503
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0019 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0847 0.716
Brugia malayi hypothetical protein 0.0021 0.0006 0.0051
Brugia malayi hypothetical protein 0.004 0.0027 0.0229
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0046 0.158
Onchocerca volvulus 0.0112 0.0108 0.2804
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0767 0.0841 0.7111
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.107 0.118 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0358 0.0383 0.0383
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0468 0.0507 0.6022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Brugia malayi SH2 domain containing protein 0.0379 0.0407 0.3443
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0051 0.0039 0.0278
Giardia lamblia Hypothetical protein 0.0166 0.0168 0.1748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0847 0.716
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0019 0.0108
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0046 0.0046
Schistosoma mansoni kinase 0.011 0.0106 0.0582
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0089 0.0081 0.064
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.107 0.118 1
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0041 0.0028 0.0249
Brugia malayi Casein kinase II, alpha chain 0.0153 0.0153 0.1297
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0275 0.029 0.0829
Brugia malayi intracellular kinase 0.0057 0.0046 0.0388
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0022 0.0022
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0118 0.073
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0033 0.0183
Echinococcus granulosus intermediate filament protein 0.003 0.0016 0.0015
Loa Loa (eye worm) hypoxia-induced factor 1 0.0168 0.017 0.1054
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0118 0.0952
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.004 0.0027 0.0179
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0006 0.0006
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0166 0.0168 0.1994
Trypanosoma brucei polo-like protein kinase 0.0214 0.0222 0.2491
Echinococcus multilocularis expressed conserved protein 0.0091 0.0084 0.0084
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0066 0.0506
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0149 0.0823
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0793 0.087 0.2503
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0081 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0303 0.0321 0.2682
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0199 0.0205 0.1272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0782 0.0858 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0502 0.4225
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0793 0.087 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0738 0.0809 0.9292
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.044 0.0475 0.262
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0275 0.029 1
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0118 0.0118
Toxoplasma gondii GAF domain-containing protein 0.0036 0.0023 0.0276
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0275 0.029 1
Entamoeba histolytica hypothetical protein 0.0894 0.0983 0.8317
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0023 0.1493
Loa Loa (eye worm) phosphatidylinositol 3 0.0166 0.0168 0.1038
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0089 0.0081 0.0081
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0033
Loa Loa (eye worm) hypothetical protein 0.0303 0.0321 0.1989
Schistosoma mansoni hypothetical protein 0.004 0.0027 0.0149
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0358 0.0383 0.3245
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0046 0.0338
Brugia malayi Pre-SET motif family protein 0.0033 0.0019 0.0162
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Echinococcus granulosus cyclin dependent kinase 19 0.0149 0.0149 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0153 0.1252
Loa Loa (eye worm) phosphatidylinositol 3 0.0738 0.0809 0.5012
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0153 0.1252
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0118 0.0952
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0081 0.0228
Echinococcus multilocularis serine protein kinase ATM 0.044 0.0475 0.0474
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0166 0.0168 0.5707
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0818 0.6915
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0451 0.0487 0.4097
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0006 0.0051
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Entamoeba histolytica protein kinase domain containing protein 0.0153 0.0153 0.1252
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0166 0.0168 0.0925
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Loa Loa (eye worm) gastrulation defective protein 1 0.0145 0.0145 0.0898
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0153 0.1252
Brugia malayi follicle stimulating hormone receptor 0.0263 0.0277 0.2348
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0772 0.0847 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0795 0.672
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1633 0.1811 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0081 0.064
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.001 0.0064
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0795 0.672
Echinococcus granulosus protein kinase shaggy 0.0057 0.0046 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0166 0.0168 0.0477
Plasmodium vivax SET domain protein, putative 0.0033 0.0019 0.0659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0767 0.0841 0.7111
Plasmodium falciparum GAF domain-related protein, putative 0.0036 0.0023 0.062
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Brugia malayi 6-phosphofructokinase 0.0121 0.0118 0.0998
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0818 0.6916
Entamoeba histolytica hypothetical protein 0.004 0.0027 0.0179
Plasmodium vivax hypothetical protein 0.0166 0.0168 0.5786
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0166 0.0168 0.1375
Giardia lamblia Kinase, CMGC CK2 0.0153 0.0153 0.1578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0424 0.0456 0.3835
Loa Loa (eye worm) hypothetical protein 0.0182 0.0186 0.1152
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0275 0.029 0.328
Schistosoma mansoni hypothetical protein 0.0107 0.0102 0.0563
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0089 0.0081 0.064
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0782 0.0858 0.0858
Trichomonas vaginalis PIKK family atypical protein kinase 0.047 0.0508 0.4274
Toxoplasma gondii FATC domain-containing protein 0.044 0.0475 0.5644
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0166 0.0168 0.0167
Loa Loa (eye worm) hypothetical protein 0.0379 0.0407 0.2519
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0023 0.0144
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0019 0.0649
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0019 0.0226
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0166 0.0168 0.0167
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0275 0.029 0.0289
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0782 0.0858 0.2469
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0103 0.082
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0118 0.0952
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0166 0.0168 0.0167
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0199 0.0205 0.1739
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0905 0.0995 0.8421
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0545 0.0593 0.4995
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0451 0.0487 0.5569
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0044 0.0242
Entamoeba histolytica hypothetical protein 0.0166 0.0168 0.1375
Onchocerca volvulus 0.0262 0.0276 0.719
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0028 0.0792
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0793 0.087 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.087 0.7355
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0214 0.0222 0.1372
Brugia malayi hypoxia-induced factor 1 0.0168 0.017 0.1441
Onchocerca volvulus 0.0046 0.0033 0.0865
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.107 0.118 1
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.001 0.0056
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0037
Loa Loa (eye worm) calcium channel 0.0036 0.0022 0.0137
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0451 0.0487 0.4097
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.024 0.1486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0818 0.6916
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0118 0.656
Trypanosoma cruzi casein kinase II, putative 0.0153 0.0153 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0818 0.6916
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0019 0.0229
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0019 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0514 0.0558 0.4701
Brugia malayi PXA domain containing protein 0.0023 0.0008 0.0066
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0036 0.0022 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0818 0.6915
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0066 0.0506
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0046 0.0338
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0166 0.0168 0.5786
Schistosoma mansoni hypothetical protein 0.0187 0.0192 0.1059
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0118 0.1291
Giardia lamblia Kinase, PLK 0.0214 0.0222 0.2381
Entamoeba histolytica hypothetical protein 0.0166 0.0168 0.1375
Onchocerca volvulus 0.004 0.0027 0.0705
Loa Loa (eye worm) phosphatidylinositol 3 0.0166 0.0168 0.1038
Brugia malayi hypothetical protein 0.0021 0.0006 0.0051
Echinococcus granulosus casein kinase ii subunit beta 0.0041 0.0028 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.0793 0.087 0.5391
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0275 0.029 0.2414
Loa Loa (eye worm) phosphatidylinositol 3 0.0285 0.0302 0.187
Loa Loa (eye worm) hypothetical protein 0.0348 0.0372 0.2307
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0039 0.0026 0.0222
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0089 0.0081 0.064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0258 0.0271 0.2256
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0019 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.087 0.7355
Brugia malayi serine/threonine-protein kinase plk-2 0.0214 0.0222 0.1876
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0166 0.0168 0.0477
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0019 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.0016 0.0096
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0051 0.0039 0.0278
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0275 0.029 0.0787
Brugia malayi Cytochrome P450 family protein 0.0033 0.0019 0.0163
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0166 0.0168 0.0925
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.001 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0037
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0118 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0019 0.0473
Entamoeba histolytica protein kinase, putative 0.0057 0.0046 0.0338
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0089 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.049 0.0531 0.447
Loa Loa (eye worm) hypothetical protein 0.0112 0.0108 0.0666
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0006 0.0006
Echinococcus granulosus bloom syndrome protein 0.0024 0.0009 0.0008
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0089 0.0081 0.0228
Entamoeba histolytica hypothetical protein 0.044 0.0475 0.399
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Brugia malayi PXA domain containing protein 0.0023 0.0008 0.0066
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0222 0.0633
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0793 0.087 0.7355
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.0277 0.1718
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0118 0.0952
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0052 0.0041 0.0293
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0027 0.0149
Brugia malayi phosphofructokinase 0.0121 0.0118 0.0998
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0006 0.0006
Schistosoma mansoni survival motor neuron protein 0.0107 0.0102 0.0563
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0118 0.065
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0358 0.0383 0.0383
Echinococcus granulosus survival motor neuron protein 1 0.0525 0.057 0.057
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0435 0.047 0.3949
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0166 0.0168 0.1867
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0424 0.0456 0.0456
Loa Loa (eye worm) phosphatidylinositol 3 0.0166 0.0168 0.1038
Loa Loa (eye worm) RecQ helicase 0.0024 0.0009 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0795 0.672
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0775 0.085 0.7199
Mycobacterium leprae conserved hypothetical protein 0.0166 0.0168 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0726 0.0795 0.672
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0222 0.1834
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0094 0.0515
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0358 0.0383 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0275 0.029 0.2414
Entamoeba histolytica protein kinase rad3, putative 0.0424 0.0456 0.3835
Loa Loa (eye worm) intermediate filament protein 0.003 0.0016 0.0096
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0275 0.029 0.1795
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0738 0.0809 0.2209
Onchocerca volvulus 0.0166 0.0168 0.4373
Loa Loa (eye worm) hypothetical protein 0.0772 0.0847 0.5249
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0153 0.1252
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0052 0.0041 0.011
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0006 0.0006
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0046 0.0317
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0089 0.0081 0.0868
Trypanosoma cruzi hypothetical protein, conserved 0.3114 0.3468 1
Echinococcus multilocularis high voltage activated calcium channel beta 0.0097 0.0091 0.009
Brugia malayi Cytochrome P450 family protein 0.0022 0.0007 0.0053
Plasmodium falciparum casein kinase 2, alpha subunit 0.0153 0.0153 0.5198
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0009 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0767 0.0841 0.7111
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0 0.0000000046503
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.0028 0.0074
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0166 0.0168 0.1994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0767 0.0841 0.7111
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0023 0.0794
Entamoeba histolytica casein kinase, putative 0.0153 0.0153 0.1252
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0275 0.029 0.2453
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0793 0.087 0.4802
Echinococcus multilocularis voltage dependent calcium channel 0.0036 0.0022 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0847 0.716
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0019 0.0105
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0342 0.0365 0.407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0772 0.0847 0.716
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0424 0.0456 0.131
Leishmania major hypothetical protein, conserved 0.0039 0.0026 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0752 0.0824 0.6965
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.001 0.001
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0036 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0015 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.087 0.7355
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0006 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0424 0.0456 0.3866
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0066 0.0506
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0006 0.0006
Echinococcus granulosus expressed protein 0.0416 0.0448 0.0448
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0182 0.0186 0.053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0019 0.0105
Leishmania major cytochrome p450-like protein 0.0022 0.0007 0.0011
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0772 0.0847 0.2313
Echinococcus granulosus high voltage activated calcium channel beta 0.0097 0.0091 0.009
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0166 0.0168 0.1994
Schistosoma mansoni hypothetical protein 0.0057 0.0046 0.0254
Schistosoma mansoni hypothetical protein 0.0091 0.0084 0.0463
Brugia malayi Protein kinase domain containing protein 0.002 0.0005 0.0036
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0799 0.0877 0.7419
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0036 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0303 0.0321 0.1772
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0153 0.1252
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0016 0.0131
Onchocerca volvulus Serine\/threonine kinase homolog 0.0214 0.0222 0.5778
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0358 0.0383 0.2374
Leishmania major phosphatidylinositol kinase, putative 0.0166 0.0168 0.0453
Schistosoma mansoni hypothetical protein 0.0166 0.0168 0.0925
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0019 0.0119
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0214 0.0222 0.0221
Brugia malayi hypothetical protein 0.0525 0.057 0.4829
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0623 0.068 0.7766
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0103 0.082
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0046 0.0317
Onchocerca volvulus 0.003 0.0016 0.0403
Echinococcus multilocularis survival motor neuron protein 1 0.0525 0.057 0.057
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0052 0.0041 0.0293
Giardia lamblia Phosphatidylinositol 4-kinase 0.0166 0.0168 0.1748
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0894 0.0983 0.8317
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0006 0.0006
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0207 0.0214 0.2398
Echinococcus granulosus expressed conserved protein 0.0091 0.0084 0.0084
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0046 0.0338
Toxoplasma gondii CMGC kinase, CK2 family 0.0153 0.0153 0.1822
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0274 0.0289 0.0828
Schistosoma mansoni fkbp-rapamycin associated protein 0.0424 0.0456 0.2519
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0275 0.029 0.2414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0435 0.047 0.3949
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.0094 0.0515
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0023 0.1493
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0006 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.107 0.118 0.3399
Echinococcus multilocularis lamin 0.003 0.0016 0.0015
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0118 0.0334
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0799 0.0877 0.7419
Echinococcus multilocularis lamin dm0 0.003 0.0016 0.0015
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0007 0.0012
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0166 0.0168 0.0167
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0053 0.0042 0.0258
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0041 0.0028 0.0334
Loa Loa (eye worm) hypothetical protein 0.0274 0.0289 0.1792
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0097 0.009 0.009
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.107 0.118 0.3399
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0358 0.0383 0.2374
Leishmania major phosphatidylinositol 3-kinase, putative 0.0275 0.029 0.0787
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0118 0.0952
Loa Loa (eye worm) hypothetical protein 0.0525 0.057 0.3532
Echinococcus granulosus lamin 0.003 0.0016 0.0015
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0118 0.065
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0275 0.029 0.0289
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0039 0.0026 0.0067
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Entamoeba histolytica hypothetical protein 0.0166 0.0168 0.1375
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0118 0.656
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0275 0.029 0.3445
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0041 0.03
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0127 0.0125 0.101
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0138 0.0137 0.0755
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0028 0.0962
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0166 0.0168 0.0477
Echinococcus multilocularis cyclin dependent kinase 19 0.0149 0.0149 0.0149
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0046 0.1422
Brugia malayi hypothetical protein 0.0112 0.0108 0.0912
Leishmania major hypothetical protein, conserved 0.3279 0.3653 1
Leishmania major casein kinase II, putative 0.0153 0.0153 0.0413
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0285 0.0302 0.0864
Trypanosoma brucei Casein kinase II 0.0153 0.0153 0.1699
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0006 0.0006
Onchocerca volvulus 0.003 0.0016 0.0403
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0075 0.0067 0.2999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0767 0.0841 0.7111
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0036 0.0022 0.0022
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0303 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0037
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0275 0.029 0.3445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0502 0.4225
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0153 0.0153 0.5286
Schistosoma mansoni intermediate filament proteins 0.003 0.0016 0.0085
Leishmania major phosphatidylinositol 3-kinase, putative 0.0726 0.0795 0.2172
Trichomonas vaginalis CAMK family protein kinase 0.0214 0.0222 0.1834
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0214 0.0222 0.0221
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0009 0.0021
Brugia malayi Pre-SET motif family protein 0.023 0.024 0.2031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0752 0.0824 0.6965
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.0028 0.0725
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0118 0.0952
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0006 0.0051
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0019 0.0108
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0303 0.0321 0.0321
Schistosoma mansoni protein kinase 0.0153 0.0153 0.0845
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0003 0.0016
Toxoplasma gondii ck2 beta subunit 0.0041 0.0028 0.0334
Brugia malayi PAS domain containing protein 0.0054 0.0043 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0186 0.0191 0.157
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0451 0.0487 0.4097
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.0028 0.0962
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.0074 0.0074
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0097 0.0091 0.0499
Brugia malayi Serotonin receptor 0.052 0.0564 0.478
Brugia malayi Death domain containing protein 0.0016 0 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0019 0.0108
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0099 0.0094 0.0093
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0006 0.0006
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0051 0.0039 0.0328
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0037
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0118 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0046 0.0284
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0019 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0046 0.0338
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0006 0.0051
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0006 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0222 0.1222
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0275 0.029 0.1598
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1633 0.1811 0.1811
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0767 0.0841 0.7111
Schistosoma mansoni serine/threonine protein kinase 0.0358 0.0383 0.2115
Toxoplasma gondii hypothetical protein 0.0074 0.0066 0.0781
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Onchocerca volvulus 0.0055 0.0044 0.1143
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0037
Echinococcus granulosus tumor protein p63 0.0377 0.0404 0.0404
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.0028 0.0186
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0039 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0044 0.0272
Echinococcus multilocularis geminin 0.0187 0.0192 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0153 0.0153 0.1252
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0468 0.0507 0.3139
Brugia malayi 6-phosphofructokinase 0.0121 0.0118 0.0998
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0153 0.0153 0.0949
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0089 0.0081 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0747 0.0818 0.6915
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0019 0.0226
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.001 0.0087
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0782 0.0858 0.0858
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0046 0.0547
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0006 0.0006
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0489 0.0529 0.6058
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.0074 0.0074
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0006 0.0033
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0019 0.0226
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0026 0.0175
Entamoeba histolytica serine/threonine protein kinase, putative 0.0214 0.0222 0.1834
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0118 0.073
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0009 0.0021
Plasmodium falciparum casein kinase II beta chain 0.0041 0.0028 0.0792
Leishmania major hypothetical protein, unknown function 0.0166 0.0168 0.0453
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0 0.0000000046503
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0166 0.0168 0.1375
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0726 0.0795 0.9136
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0772 0.0847 0.9735
Schistosoma mansoni lamin 0.003 0.0016 0.0085
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0089 0.0081 0.064
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.0168 1
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0006 0.0033
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.001 0.0064
Brugia malayi Protein kinase domain containing protein 0.0149 0.0149 0.1263
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.044 0.0475 0.4021
Schistosoma mansoni ankyrin 23/unc44 0.0016 0 0.000000025682
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0502 0.0544 0.458
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0275 0.029 0.2414
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0089 0.0081 0.064
Trypanosoma cruzi target of rapamycin kinase 3 0.0772 0.0847 0.2437
Echinococcus granulosus geminin 0.0187 0.0192 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0464 0.0502 0.4225
Toxoplasma gondii hypothetical protein 0.0036 0.0023 0.0276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0793 0.087 0.7369
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0782 0.0858 0.4737
Loa Loa (eye worm) hypothetical protein 0.0424 0.0456 0.2828
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0451 0.0487 0.4097
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0051 0.0039 0.0039
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0166 0.0168 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0166 0.0168 0.1375
Trypanosoma cruzi polo-like protein kinase, putative 0.0214 0.0222 0.0633
Entamoeba histolytica hypothetical protein 0.004 0.0027 0.0179

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.77 MHC class I HLA-A*0201 binding affinity assayed by based inhibition of binding of a radiolabeled standard peptide (FLPSDYFPSV) ChEMBL. 11606121
Log IC50 (binding) = 7.77 MHC class I HLA-A*0201 binding affinity assayed by based inhibition of binding of a radiolabeled standard peptide (FLPSDYFPSV) ChEMBL. 11606121

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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