Detailed information for compound 408547

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1374.97 | Formula: C67H88ClN17O13
  • H donors: 14 H acceptors: 14 LogP: 0.62 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC(C[C@@H]1NC(=O)[C@@H](Cc2ccc3c(c2)cccc3)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC(=O)NC[C@@H](NC(=O)[C@H]3N(C(=O)[C@@H](NC1=O)CCCCNC(=O)CC[C@H](NC(=O)C)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N2)Cc1cccnc1)Cc1ccc(cc1)Cl)CCC3)C(=O)N)C
  • InChi: 1S/C67H88ClN17O13/c1-37(2)29-48-60(92)78-47-14-6-7-26-73-55(87)24-23-46(76-38(3)86)59(91)80-49(31-39-18-21-44(68)22-19-39)61(93)82-51(33-41-11-8-25-72-35-41)63(95)83-52(34-56(88)75-36-53(57(69)89)84-65(97)54-16-10-28-85(54)66(47)98)64(96)77-45(15-9-27-74-67(70)71)58(90)81-50(62(94)79-48)32-40-17-20-42-12-4-5-13-43(42)30-40/h4-5,8,11-13,17-22,25,30,35,37,45-54H,6-7,9-10,14-16,23-24,26-29,31-34,36H2,1-3H3,(H2,69,89)(H,73,87)(H,75,88)(H,76,86)(H,77,96)(H,78,92)(H,79,94)(H,80,91)(H,81,90)(H,82,93)(H,83,95)(H,84,97)(H4,70,71,74)/t45-,46-,47-,48-,49-,50+,51+,52-,53+,54-/m0/s1
  • InChiKey: SINVKJYCIHJXPC-WECHBYPSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide receptor Gonadotropin-releasing hormone receptor   327 aa 263 aa 24.0 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 336 aa 19.0 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 292 aa 19.5 %
Echinococcus granulosus tm gpcr rhodopsin Gonadotropin-releasing hormone receptor   327 aa 299 aa 23.1 %
Brugia malayi ORL1-like opioid receptor Gonadotropin-releasing hormone receptor   327 aa 293 aa 20.8 %
Schistosoma mansoni peptide (allatostatin)-like receptor Gonadotropin-releasing hormone receptor   327 aa 272 aa 23.2 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Gonadotropin-releasing hormone receptor   327 aa 290 aa 19.7 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Gonadotropin-releasing hormone receptor   327 aa 263 aa 23.2 %
Echinococcus multilocularis neuropeptide receptor Gonadotropin-releasing hormone receptor   327 aa 263 aa 20.9 %
Echinococcus multilocularis allatostatin A receptor Gonadotropin-releasing hormone receptor   327 aa 279 aa 23.7 %
Echinococcus multilocularis tachykinin peptides receptor 99D Gonadotropin-releasing hormone receptor   327 aa 283 aa 20.1 %
Echinococcus granulosus tachykinin peptides receptor 99D Gonadotropin-releasing hormone receptor   327 aa 283 aa 19.1 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 284 aa 19.4 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Gonadotropin-releasing hormone receptor   327 aa 343 aa 21.6 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 271 aa 20.7 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Gonadotropin-releasing hormone receptor   327 aa 288 aa 24.3 %
Loa Loa (eye worm) hypothetical protein Gonadotropin-releasing hormone receptor   327 aa 334 aa 21.6 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Gonadotropin-releasing hormone receptor   327 aa 305 aa 24.9 %
Echinococcus granulosus allatostatin A receptor Gonadotropin-releasing hormone receptor   327 aa 284 aa 22.9 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Gonadotropin-releasing hormone receptor   327 aa 273 aa 19.8 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Gonadotropin-releasing hormone receptor   327 aa 288 aa 27.8 %
Onchocerca volvulus Gonadotropin-releasing hormone receptor   327 aa 336 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0169 0.0139 0.013
Toxoplasma gondii microneme protein MIC17B 0.0247 0.022 0.0532
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0196 0.0168 0.0168
Echinococcus multilocularis transmembrane protease serine 3 0.0169 0.0139 0.0139
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0397 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Brugia malayi Delta serrate ligand family protein 0.0201 0.0173 0.0173
Echinococcus multilocularis notch 0.0201 0.0173 0.0173
Onchocerca volvulus 0.0247 0.022 0.2402
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0093 0.0061 0.0061
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0079 0.0047 0.0038
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Schistosoma mansoni protein kinase 0.9742 0.9994 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) PAN domain-containing protein 0.0247 0.022 0.0211
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.2448 0.2485 0.2487
Schistosoma mansoni Protein aveugle 0.0079 0.0047 0.0047
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0196 0.0168 0.0168
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0196 0.0168 0.0168
Onchocerca volvulus 0.0201 0.0173 0.1861
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0027 0.0027
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0063 0.0031 0.0031
Echinococcus granulosus Nuclear hormone receptor HR96 0.0093 0.0061 0.0061
Loa Loa (eye worm) trypsin family protein 0.0169 0.0139 0.013
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Echinococcus granulosus TGF-beta receptor type-1 0.9742 0.9994 1
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0079 0.0047 0.5
Brugia malayi nuclear hormone receptor 0.0093 0.0061 0.0061
Echinococcus multilocularis polyhomeotic protein 2 0.0079 0.0047 0.0047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0196 0.0168 0.0168
Brugia malayi Shank2E 0.0079 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase Srms 0.0059 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Loa Loa (eye worm) PAN domain-containing protein 0.0247 0.022 0.0211
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0063 0.0031 0.0031
Onchocerca volvulus 0.0201 0.0173 0.1861
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0196 0.0168 0.0168
Onchocerca volvulus 0.0079 0.0047 0.0427
Echinococcus multilocularis activin receptor type 0.4428 0.4524 0.4527
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0169 0.0139 0.0139
Schistosoma mansoni notch 0.0201 0.0173 0.0173
Brugia malayi steroid hormone receptor 0.0196 0.0168 0.0168
Onchocerca volvulus 0.0201 0.0173 0.1861
Onchocerca volvulus Bile acid receptor homolog 0.0196 0.0168 0.1805
Brugia malayi Trypsin family protein 0.0169 0.0139 0.0139
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1572 0.1584 1
Brugia malayi hypothetical protein 0.0079 0.0047 0.0047
Toxoplasma gondii PAN domain-containing protein 0.0247 0.022 0.0532
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0063 0.0031 0.0031
Schistosoma mansoni zinc finger protein 0.0093 0.0061 0.0061
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0169 0.0139 0.0139
Echinococcus multilocularis Sterile alpha motif SAM 0.0079 0.0047 0.0047
Echinococcus multilocularis neural cadherin 0.0201 0.0173 0.0173
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0196 0.0168 0.0159
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.0031 0.0031
Echinococcus multilocularis slit 2 protein 0.0201 0.0173 0.0173
Schistosoma mansoni coup transcription factor 0.0196 0.0168 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0196 0.0168 0.0168
Onchocerca volvulus Slit protein homolog 0.0201 0.0173 0.1861
Loa Loa (eye worm) hypothetical protein 0.0247 0.022 0.0211
Onchocerca volvulus 0.0079 0.0047 0.0427
Brugia malayi Trypsin-like protease protein 5 0.0169 0.0139 0.0139
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0046 0.0013 0.0013
Toxoplasma gondii subtilisin SUB12 0.0247 0.022 0.0532
Echinococcus multilocularis protein jagged 1 0.0201 0.0173 0.0173
Brugia malayi hypothetical protein 0.0043 0.001 0.001
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1572 0.1584 1
Brugia malayi nuclear hormone receptor 0.0196 0.0168 0.0168
Brugia malayi GnHR receptor homolog 0.0558 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0247 0.022 0.0211
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) TK protein kinase 0.0055 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Echinococcus granulosus Sterile alpha motif type 0.0079 0.0047 0.0047
Echinococcus multilocularis histone acetyltransferase myst3 0.0079 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0079 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) hypothetical protein 0.3738 0.3814 0.3808
Echinococcus granulosus neurogenic locus notch protein 0.0201 0.0173 0.0173
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Brugia malayi hypothetical protein 0.0093 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0169 0.0139 0.0139
Brugia malayi Liprin-alpha 2 0.0079 0.0047 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0196 0.0168 0.0168
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.9747 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0196 0.0168 0.0168
Echinococcus granulosus enteropeptidase 0.0169 0.0139 0.0139
Echinococcus multilocularis protein jagged 1 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0169 0.0139 0.013
Brugia malayi Nuclear hormone receptor E75 0.0093 0.0061 0.0061
Schistosoma mansoni thyroid hormone receptor 0.2644 0.2688 0.2689
Onchocerca volvulus 0.0093 0.0061 0.0587
Brugia malayi hypothetical protein 0.0169 0.0139 0.0139
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0196 0.0168 0.0168
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0196 0.0168 0.0168
Echinococcus granulosus histone acetyltransferase myst3 0.0079 0.0047 0.0047
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Onchocerca volvulus 0.0169 0.0139 0.1477
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Brugia malayi ecdysteroid receptor 0.0196 0.0168 0.0168
Schistosoma mansoni notch 0.0201 0.0173 0.0173
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Brugia malayi EGF-like domain containing protein 0.0201 0.0173 0.0173
Onchocerca volvulus 0.0247 0.022 0.2402
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.2448 0.2485 0.2487
Brugia malayi EGF-like domain containing protein 0.0201 0.0173 0.0173
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Schistosoma mansoni phd finger protein 0.0079 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0196 0.0168 0.0159
Echinococcus granulosus mitogen activated protein kinase 14 0.1572 0.1584 0.1585
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1572 0.1584 1
Echinococcus multilocularis FTZ F1 alpha 0.0196 0.0168 0.0168
Echinococcus multilocularis nuclear receptor nhr 48 0.0093 0.0061 0.0061
Brugia malayi orphan nuclear receptor NR2E1 0.0093 0.0061 0.0061
Echinococcus multilocularis liprin alpha 2 0.0079 0.0047 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0196 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Echinococcus granulosus tyrosine protein kinase HCK 0.0055 0.0023 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0093 0.0061 0.0061
Brugia malayi cask-interacting protein 2 0.0079 0.0047 0.0047
Brugia malayi nuclear receptor NHR-88 0.0196 0.0168 0.0168
Brugia malayi nuclear receptor RXR 0.0093 0.0061 0.0061
Toxoplasma gondii PAN domain-containing protein 0.3843 0.3922 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Toxoplasma gondii hypothetical protein 0.0247 0.022 0.0532
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0169 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0169 0.0139 0.013
Trypanosoma cruzi Kinesin-13 5, putative 0.0079 0.0047 0.022
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Onchocerca volvulus 0.0247 0.022 0.2402
Brugia malayi EGF-like domain containing protein 0.0201 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0201 0.0173 0.0173
Brugia malayi Muscle positioning protein 4 0.0201 0.0173 0.0173
Toxoplasma gondii microneme protein MIC17A 0.0247 0.022 0.0532
Onchocerca volvulus 0.0079 0.0047 0.0427
Schistosoma mansoni lip-related protein (liprin) alpha 0.0079 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0196 0.0168 0.0159
Toxoplasma gondii PAN domain-containing protein 0.3843 0.3922 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Toxoplasma gondii microneme protein, putative 0.0247 0.022 0.0532
Loa Loa (eye worm) hypothetical protein 0.0104 0.0073 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0196 0.0168 0.0168
Echinococcus multilocularis tyrosine protein kinase Blk 0.0059 0.0027 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0181 0.0152 0.0152
Schistosoma mansoni cell polarity protein 0.0201 0.0173 0.0173
Brugia malayi coiled-coil like protein 1 0.0079 0.0047 0.0047
Schistosoma mansoni steroid hormone receptor ad4bp 0.0196 0.0168 0.0168
Schistosoma mansoni slit 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Echinococcus multilocularis ecdysone induced protein 78C 0.0196 0.0168 0.0168
Echinococcus multilocularis neurogenic locus protein delta 0.0201 0.0173 0.0173
Schistosoma mansoni protein kinase 0.0046 0.0013 0.0013
Brugia malayi nuclear receptor NHR-88 0.0093 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Brugia malayi Cadherin domain containing protein 0.0201 0.0173 0.0173
Onchocerca volvulus 0.0169 0.0139 0.1477
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0063 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Echinococcus granulosus tyrosine kinase 0.0059 0.0027 0.0027
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0063 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1572 0.1584 0.1576
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1572 0.1584 1
Loa Loa (eye worm) steroid hormone receptor 0.0196 0.0168 0.0159
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0201 0.0173 0.0173
Echinococcus multilocularis mitogen activated protein kinase 11 0.1572 0.1584 0.1585
Loa Loa (eye worm) SRC-1 0.0063 0.0031 0.0021
Echinococcus granulosus transmembrane protease serine 3 0.0169 0.0139 0.0139
Onchocerca volvulus 0.0169 0.0139 0.1477
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Onchocerca volvulus 0.0093 0.0061 0.0587
Onchocerca volvulus Tankyrase homolog 0.0079 0.0047 0.0427
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0063 0.0031 0.0031
Echinococcus granulosus ecdysone induced protein 78C 0.0196 0.0168 0.0168
Brugia malayi EGF-like domain containing protein 0.0201 0.0173 0.0173
Loa Loa (eye worm) Notch2 0.0201 0.0173 0.0163
Echinococcus multilocularis enteropeptidase 0.0169 0.0139 0.0139
Schistosoma mansoni tyrosine kinase 0.0063 0.0031 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0196 0.0168 0.0168
Schistosoma mansoni nuclear receptor nhr-48 0.0093 0.0061 0.0061
Echinococcus multilocularis liprin alpha 2 0.0079 0.0047 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0196 0.0168 0.0168
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0079 0.0047 0.0047
Echinococcus granulosus notch 0.0201 0.0173 0.0173
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0079 0.0047 0.0047
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0093 0.0061 0.0061
Echinococcus granulosus liprin alpha 2 0.0079 0.0047 0.0047
Loa Loa (eye worm) PAN domain-containing protein 0.0247 0.022 0.0211
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Brugia malayi Calcium binding EGF domain containing protein 0.0201 0.0173 0.0173
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Plasmodium vivax tyrosine kinase-like protein, putative 0.0397 0.0375 1
Brugia malayi bicaudal-C 0.0079 0.0047 0.0047
Brugia malayi protein-tyrosine kinase 0.0059 0.0027 0.0027
Schistosoma mansoni notch 0.0201 0.0173 0.0173
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0196 0.0168 0.0168
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0169 0.0139 0.0139
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0429 0.0407 0.0408
Brugia malayi P38 map kinase family protein 2 0.1572 0.1584 0.1584
Schistosoma mansoni notch 0.0201 0.0173 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0247 0.022 0.0211
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0104 0.0073 0.0073
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0247 0.022 0.0532
Onchocerca volvulus 0.0247 0.022 0.2402
Echinococcus granulosus mitogen activated protein kinase 11 0.1572 0.1584 0.1585
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0093 0.0061 0.0587
Echinococcus granulosus delta-like protein 1 0.0201 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0104 0.0073 0.0063
Loa Loa (eye worm) notch protein 0.0201 0.0173 0.0163
Schistosoma mansoni DNAj-like protein 0.0079 0.0047 0.0047
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Echinococcus granulosus slit 2 protein 0.0201 0.0173 0.0173
Onchocerca volvulus 0.0196 0.0168 0.1805
Echinococcus granulosus pdz domain containing protein 0.0079 0.0047 0.0047
Echinococcus granulosus protein jagged 2 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0196 0.0168 0.0168
Brugia malayi nuclear receptor NHR-67 0.0093 0.0061 0.0061
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0093 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Echinococcus multilocularis neurogenic locus notch protein 0.0201 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.2448 0.2485 0.2487
Onchocerca volvulus 0.0247 0.022 0.2402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0196 0.0168 0.0159
Trichomonas vaginalis cgi-62, putative 0.0079 0.0047 0.5
Loa Loa (eye worm) hypothetical protein 0.0247 0.022 0.0211
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Echinococcus multilocularis mitogen activated protein kinase 11 0.1572 0.1584 0.1585
Schistosoma mansoni hypothetical protein 0.0201 0.0173 0.0173
Brugia malayi Trypsin family protein 0.0429 0.0407 0.0407
Loa Loa (eye worm) tnks protein 0.0079 0.0047 0.0038
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0079 0.0047 0.022
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Onchocerca volvulus Putative cubilin 0.0201 0.0173 0.1861
Brugia malayi Calcium binding EGF domain containing protein 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0104 0.0073 0.0063
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0059 0.0027 0.0027
Echinococcus granulosus activin receptor type 0.4428 0.4524 0.4527
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Toxoplasma gondii microneme protein MIC4 0.0247 0.022 0.0532
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0047 0.5
Schistosoma mansoni caspase-7 (C14 family) 0.0043 0.001 0.001
Brugia malayi hypothetical protein 0.3738 0.3814 0.3814
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0196 0.0168 0.0168
Schistosoma mansoni notch 0.0201 0.0173 0.0173
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0093 0.0061 0.0587
Echinococcus multilocularis neurogenic locus notch protein 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Schistosoma mansoni nuclear receptor 0.0093 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Schistosoma mansoni polyhomeotic 0.0079 0.0047 0.0047
Onchocerca volvulus 0.0169 0.0139 0.1477
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Echinococcus granulosus sphingomyelin synthase protein 1 0.0079 0.0047 0.0047
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0079 0.0047 0.0047
Brugia malayi hypothetical protein 0.0104 0.0073 0.0073
Echinococcus granulosus tyrosine protein kinase Lyn 0.0083 0.0051 0.0051
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0169 0.0139 0.0139
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0079 0.0047 0.0047
Onchocerca volvulus 0.0247 0.022 0.2402
Echinococcus granulosus glycoprotein Antigen 5 0.0169 0.0139 0.0139
Schistosoma mansoni protein kinase 0.0046 0.0013 0.0013
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0196 0.0168 0.0168
Echinococcus granulosus neurogenic locus protein delta 0.0201 0.0173 0.0173
Loa Loa (eye worm) PAN domain-containing protein 0.0247 0.022 0.0211
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0196 0.0168 0.0168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0169 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0201 0.0173 0.0173
Echinococcus granulosus thyroid hormone receptor alpha 0.0093 0.0061 0.0061
Toxoplasma gondii PAN domain-containing protein 0.0247 0.022 0.0532
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0169 0.0139 0.0139
Onchocerca volvulus 0.0429 0.0407 0.4532
Onchocerca volvulus 0.0079 0.0047 0.0427
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0169 0.0139 0.013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0196 0.0168 0.1805
Schistosoma mansoni nuclear receptor 0.0093 0.0061 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Brugia malayi EGF-like domain containing protein 0.0201 0.0173 0.0173
Brugia malayi hypothetical protein 0.0093 0.0061 0.0061
Echinococcus granulosus protein jagged 1 0.0201 0.0173 0.0173
Brugia malayi Trypsin family protein 0.0169 0.0139 0.0139
Onchocerca volvulus 0.0079 0.0047 0.0427
Echinococcus granulosus tyrosine protein kinase Src42A 0.0063 0.0031 0.0031
Echinococcus granulosus TGF beta receptor type 1 0.9742 0.9994 1
Echinococcus granulosus nuclear receptor nhr 48 0.0093 0.0061 0.0061
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0196 0.0168 0.0168
Onchocerca volvulus 0.0247 0.022 0.2402
Schistosoma mansoni hypothetical protein 0.0043 0.001 0.001
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0247 0.022 0.0211
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0104 0.0073 0.0073
Onchocerca volvulus 0.0247 0.022 0.2402
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Echinococcus multilocularis polycomb protein SCMH1 0.0079 0.0047 0.0047
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Toxoplasma gondii hypothetical protein 0.0247 0.022 0.0532
Schistosoma mansoni retinoic acid receptor RXR 0.0196 0.0168 0.0168
Onchocerca volvulus 0.0247 0.022 0.2402
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0196 0.0168 0.0168
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0196 0.0168 0.0168
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0063 0.0031 0.0031
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0169 0.0139 0.0139
Onchocerca volvulus 0.0201 0.0173 0.1861
Brugia malayi photoreceptor-specific nuclear receptor 0.0196 0.0168 0.0168
Echinococcus multilocularis neurogenic locus protein delta 0.0201 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0169 0.0139 0.0139
Brugia malayi tailless protein 0.0093 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Loa Loa (eye worm) hypothetical protein 0.0104 0.0073 0.0063
Toxoplasma gondii PAN/Apple domain-containing protein 0.0247 0.022 0.0532
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0046 0.0013 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0093 0.0061 0.0061
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0429 0.0407 0.0398
Echinococcus granulosus neurogenic locus notch protein 4 0.0201 0.0173 0.0173
Echinococcus multilocularis fat cadherin tumor suppressor 0.0201 0.0173 0.0173
Echinococcus granulosus polyhomeotic protein 2 0.0079 0.0047 0.0047
Brugia malayi ecdysone receptor 0.0093 0.0061 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Loa Loa (eye worm) nuclear receptor NHR-67 0.0093 0.0061 0.0052
Schistosoma mansoni notch 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) hypothetical protein 0.0429 0.0407 0.0398
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0196 0.0168 0.0168
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0201 0.0173 0.0173
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0397 0.0375 0.0927
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0196 0.0168 0.0159
Onchocerca volvulus 0.0201 0.0173 0.1861
Giardia lamblia High cysteine protein 0.0201 0.0173 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0196 0.0168 0.0168
Onchocerca volvulus 0.0247 0.022 0.2402
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0429 0.0407 0.0408
Echinococcus granulosus neurogenic locus notch protein 0.0201 0.0173 0.0173
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0093 0.0061 0.0061
Echinococcus multilocularis mitogen activated protein kinase 14 0.1572 0.1584 0.1585
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0196 0.0168 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0196 0.0168 0.0168
Brugia malayi protein C17H12.11 0.3738 0.3814 0.3814
Brugia malayi EGF-like domain containing protein 0.0201 0.0173 0.0173
Loa Loa (eye worm) TK protein kinase 0.0059 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Onchocerca volvulus Neurogenic locus notch homolog 0.0201 0.0173 0.1861
Brugia malayi Sphingomyelin synthase-related 1 0.0079 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0201 0.0173 0.0173
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0196 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0079 0.0047 0.0047
Echinococcus multilocularis Mastin 0.0169 0.0139 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0196 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0196 0.0168 0.0168
Schistosoma mansoni thyroid hormone receptor 0.2644 0.2688 0.2689
Brugia malayi Cadherin domain containing protein 0.0201 0.0173 0.0173
Brugia malayi conserved hypotetical protein 0.0093 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.0142 0.1504
Mycobacterium ulcerans hypothetical protein 0.0169 0.0139 0.5
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Loa Loa (eye worm) AIDA-1b 0.0079 0.0047 0.0038
Echinococcus granulosus liprin alpha 2 0.0079 0.0047 0.0047
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0079 0.0047 0.022
Echinococcus multilocularis mitogen activated protein kinase 14 0.1572 0.1584 0.1585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0196 0.0168 0.0159
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0093 0.0061 0.0061
Brugia malayi EGF-like domain containing protein 0.0201 0.0173 0.0173
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0196 0.0168 0.0168
Schistosoma mansoni laminin gamma-3 chain 0.0201 0.0173 0.0173
Brugia malayi AIDA-1b 0.0079 0.0047 0.0047
Echinococcus multilocularis fibropellin Ia 0.0201 0.0173 0.0173
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0079 0.0047 0.0047
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0093 0.0061 0.0061
Echinococcus granulosus protein jagged 1 0.0201 0.0173 0.0173
Schistosoma mansoni tyrosine kinase 0.0063 0.0031 0.0031
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.3758 0.3835 0.3829
Echinococcus granulosus caspase 2 0.0043 0.001 0.001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0169 0.0139 0.0139
Brugia malayi nuclear hormone receptor family member odr-7 0.0093 0.0061 0.0061
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0196 0.0168 0.0168
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0093 0.0061 0.0061
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.4403 0.4498 0.4501
Loa Loa (eye worm) hypothetical protein 0.0104 0.0073 0.0063
Onchocerca volvulus 0.0143 0.0113 0.1175
Brugia malayi Cell death protein 3 precursor 0.0043 0.001 0.001
Trypanosoma cruzi Kinesin-13 5, putative 0.0079 0.0047 0.022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0093 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0104 0.0073 0.0063
Onchocerca volvulus Protein ultraspiracle homolog 0.0196 0.0168 0.1805
Echinococcus granulosus FTZ F1 alpha 0.0196 0.0168 0.0168
Echinococcus multilocularis pdz domain containing protein 0.0079 0.0047 0.0047
Echinococcus multilocularis thyroid hormone receptor alpha 0.2644 0.2688 0.2689
Entamoeba histolytica protein kinase, putative 0.0055 0.0023 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0063 0.0031 0.0031
Echinococcus granulosus fibropellin Ia 0.0201 0.0173 0.0173
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0093 0.0061 0.0061
Schistosoma mansoni septate junction protein 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0247 0.022 0.0211
Loa Loa (eye worm) DR-78 0.0093 0.0061 0.0052
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.0031 0.0031
Echinococcus granulosus polycomb protein SCMH1 0.0079 0.0047 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0104 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.3758 0.3835 0.3829
Brugia malayi Calcium binding EGF domain containing protein 0.0201 0.0173 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.0073 0.0073
Brugia malayi SRC-1 0.0063 0.0031 0.0031
Onchocerca volvulus 0.0247 0.022 0.2402
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) hypothetical protein 0.0247 0.022 0.0211
Schistosoma mansoni protein kinase 0.0046 0.0013 0.0013
Onchocerca volvulus 0.0895 0.0887 1
Echinococcus multilocularis protein jagged 2 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Onchocerca volvulus 0.026 0.0234 0.2555
Brugia malayi nuclear receptor RXR 0.0104 0.0073 0.0073
Echinococcus multilocularis glycoprotein Antigen 5 0.0169 0.0139 0.0139
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0093 0.0061 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0093 0.0061 0.0061
Onchocerca volvulus 0.0169 0.0139 0.1477
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Echinococcus granulosus tyrosine protein kinase Blk 0.0059 0.0027 0.0027
Brugia malayi hypothetical protein 0.0104 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0201 0.0173 0.0173
Schistosoma mansoni spingomyelin synthetase-related 0.0079 0.0047 0.0047
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0079 0.0047 0.0047
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0093 0.0061 0.0052
Echinococcus granulosus Sterile alpha motif SAM 0.0079 0.0047 0.0047
Echinococcus granulosus protein jagged 2 0.0201 0.0173 0.0173
Schistosoma mansoni RAR-like nuclear receptor 0.0196 0.0168 0.0168
Toxoplasma gondii PAN domain-containing protein 0.0247 0.022 0.0532
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Brugia malayi Protein kinase domain containing protein 0.3758 0.3835 0.3835
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Onchocerca volvulus 0.0079 0.0047 0.0427
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Echinococcus multilocularis Sterile alpha motif type 0.0079 0.0047 0.0047
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0063 0.0031 0.0031
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Echinococcus multilocularis TGF beta receptor type 1 0.9742 0.9994 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0201 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0169 0.0139 0.013
Loa Loa (eye worm) PAN domain-containing protein 0.0247 0.022 0.0211
Brugia malayi notch-like transmembrane receptor 0.0201 0.0173 0.0173
Toxoplasma gondii microneme protein MIC17C 0.0247 0.022 0.0532
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0201 0.0173 0.0163
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0181 0.0152 0.0143
Schistosoma mansoni protein kinase 0.4409 0.4504 0.4507
Brugia malayi hypothetical protein 0.0079 0.0047 0.0047
Brugia malayi Trypsin family protein 0.0169 0.0139 0.0139
Brugia malayi GCC2 and GCC3 family protein 0.0201 0.0173 0.0173
Echinococcus granulosus neural cadherin 0.0201 0.0173 0.0173
Schistosoma mansoni sex comb on midleg homolog 0.0079 0.0047 0.0047
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0169 0.0139 0.0139
Brugia malayi Nuclear hormone receptor E75 0.0093 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor 0.0093 0.0061 0.0052
Toxoplasma gondii EGF family domain-containing protein 0.0201 0.0173 0.041
Schistosoma mansoni hypothetical protein 0.0169 0.0139 0.0139
Toxoplasma gondii PAN domain-containing protein 0.0247 0.022 0.0532
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0079 0.0047 0.0047
Brugia malayi PAN domain containing protein 0.0247 0.022 0.022
Schistosoma mansoni nuclear hormone receptor 0.0196 0.0168 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0196 0.0168 0.0168
Schistosoma mansoni sex comb on midleg homolog 0.0079 0.0047 0.0047
Echinococcus multilocularis caspase 2 0.0043 0.001 0.001
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0201 0.0173 0.1861
Echinococcus granulosus Mastin 0.0169 0.0139 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0196 0.0168 0.0168
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0104 0.0073 0.0073
Echinococcus granulosus tyrosine protein kinase Src64B 0.0063 0.0031 0.0031
Echinococcus multilocularis tyrosine protein kinase HCK 0.0055 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0093 0.0061 0.0052
Schistosoma mansoni Protein aveugle 0.0079 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0079 0.0047 0.0038
Onchocerca volvulus 0.0079 0.0047 0.0427
Schistosoma mansoni cercarial elastase (S01 family) 0.0169 0.0139 0.0139
Trypanosoma cruzi hypothetical protein 0.0079 0.0047 0.022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0196 0.0168 0.0168
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0196 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0196 0.0168 0.0159
Schistosoma mansoni hypothetical protein 0.0201 0.0173 0.0173
Echinococcus granulosus tyrosine protein kinase Fyn 0.0063 0.0031 0.0031
Brugia malayi nuclear hormone receptor family member nhr-6 0.0093 0.0061 0.0061

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.1 nM Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor ChEMBL. 10715149
Ki (binding) = 1.1 nM Affinity for rat gonadotrophin releasing hormone (GnRH) receptor using HEK-293 cells transfected with rat Gonadotropin-releasing hormone receptor ChEMBL. 10715149
Ovulating rats (functional) = 0 Antiovulatory potency at 50 ug/rat expressed as rats ovulating by total no. of rats (0/5) ChEMBL. 10715149
Ovulating rats (functional) = 7 Antiovulatory potency at 250 ug/rat expressed as rats ovulating by total no. of rats (7/7) ChEMBL. 10715149

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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