Detailed information for compound 421312

Basic information

Technical information
  • TDR Targets ID: 421312
  • Name: 3-[[3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl] -1,4-dihydroindeno[1,2-c]pyrazol-6-yl]methyl] -1,3-thiazolidine
  • MW: 469.621 | Formula: C27H23N3OS2
  • H donors: 1 H acceptors: 1 LogP: 5.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)OCC#Cc1scc(c1)c1n[nH]c2c1Cc1c2ccc(c1)CN1CSCC1
  • InChi: 1S/C27H23N3OS2/c1-2-5-22(6-3-1)31-11-4-7-23-14-21(17-33-23)26-25-15-20-13-19(16-30-10-12-32-18-30)8-9-24(20)27(25)29-28-26/h1-3,5-6,8-9,13-14,17H,10-12,15-16,18H2,(H,28,29)
  • InChiKey: TZPYWYLKGBZDHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[3-[5-(3-phenoxyprop-1-ynyl)-3-thienyl]-1,4-dihydroindeno[1,2-c]pyrazol-6-yl]methyl]thiazolidine
  • 3-[5-[3-(phenoxy)prop-1-ynyl]thiophen-3-yl]-6-(1,3-thiazolidin-3-ylmethyl)-1,4-dihydroindeno[2,3-d]pyrazole
  • 3-[5-[3-(phenoxy)prop-1-ynyl]-3-thienyl]-6-(thiazolidin-3-ylmethyl)-1,4-dihydroindeno[2,3-d]pyrazole
  • 3-[5-[3-(phenoxy)prop-1-ynyl]-3-thienyl]-6-(3-thiazolidinylmethyl)-1,4-dihydroindeno[2,3-d]pyrazole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.049 0.3365 0.5741
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.049 0.3365 0.3365
Toxoplasma gondii hypothetical protein 0.0118 0.0736 0.1212
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.007 0.0395 0.039
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0014 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0027
Echinococcus multilocularis brain tumor protein 0.0037 0.0164 0.015
Loa Loa (eye worm) hypothetical protein 0.007 0.0395 0.039
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0071
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0014 0.0009
Schistosoma mansoni histamine h1 receptor 0.0016 0.0014 0.0014
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0093 0.0554 0.0746
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0014 0.0009
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0215 0.021
Mycobacterium ulcerans hypothetical protein 0.0048 0.0238 0.1383
Trypanosoma brucei lanosterol synthase 0.1006 0.701 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0033 0.0002
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0372 0.2529 0.3577
Schistosoma mansoni amine GPCR 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0032 0.0027
Trichomonas vaginalis A-type flavoprotein 0.0048 0.0238 0.0355
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0032 0.0027
Schistosoma mansoni myosin xvIII 0.0016 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0106
Schistosoma mansoni amine GPCR 0.0016 0.0014 0.0014
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.084 0.5839 1
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0894 0.0881
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0014 0.0009
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0014 0.0009
Echinococcus multilocularis zinc phosphodiesterase 0.0048 0.0238 0.0224
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0048 0.0238 0.0355
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0355 0.0556
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0047 0.023 0.023
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0413 0.0399
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0355 0.0461
Loa Loa (eye worm) hypothetical protein 0.0068 0.0383 0.0378
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0372 0.2529 0.2518
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0048 0.0238 0.0294
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0271 0.1819 0.3076
Echinococcus granulosus g protein coupled receptor 0.0016 0.0014 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0224 0.0219
Echinococcus granulosus Squalene phytoene synthase 0.0229 0.1516 0.1511
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0271 0.1819 0.2559
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0194 0.0279
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0047 0.023 0.023
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0372 0.2529 0.3577
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.084 0.5839 0.5836
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0372 0.2529 0.3577
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0048 0.0238 0.0294
Schistosoma mansoni brat protein 0.0037 0.0164 0.0164
Trypanosoma brucei protein farnesyltransferase beta subunit 0.084 0.5839 0.8321
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0372 0.2529 0.4299
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0163 0.0158
Schistosoma mansoni neprilysin-2 (M13 family) 0.0047 0.023 0.023
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0048 0.0238 0.0224
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1533 0.2585
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0383 0.0378
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0032 0.0032
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0093 0.0554 0.0554
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0372 0.2529 0.2518
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0605 0.4177 0.7139
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.2529 0.3577
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0194 0.0279
Entamoeba histolytica metallo-beta-lactamase family protein 0.0048 0.0238 0.0355
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0163 0.0149
Onchocerca volvulus 0.0231 0.1533 0.5167
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0014 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0106
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0569 0.392 0.6695
Loa Loa (eye worm) hypothetical protein 0.0759 0.5264 0.5262
Schistosoma mansoni opsin-like receptor 0.0016 0.0014 0.0014
Trypanosoma cruzi glyoxalase II 0.0048 0.0238 0.0294
Onchocerca volvulus 0.0029 0.0106 0.0311
Brugia malayi Ets-domain containing protein 0.0073 0.0413 0.0399
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0048 0.0238 0.0762
Trypanosoma cruzi hypothetical protein, conserved 0.0372 0.2529 0.3577
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0032 0.0032
Echinococcus multilocularis roundabout 2 0.0018 0.0025 0.0011
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0118 0.0736 0.1213
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0238 0.0355
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0014 0.0009
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0168 0.0232
Treponema pallidum ribonuclease Z 0.0048 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Trypanosoma cruzi protein farnesyltransferase, putative 0.084 0.5839 0.8321
Echinococcus granulosus fmrfamide receptor 0.0016 0.0014 0.0009
Echinococcus granulosus ETHE1 protein 0.0048 0.0238 0.0233
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0014 0.0014
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0014 0.0009
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0032 0.0027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0014 0.0009
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0014 0.0009
Brugia malayi Peptidase family M13 containing protein 0.0093 0.0554 0.054
Schistosoma mansoni cell adhesion molecule 0.0015 0.0005 0.0005
Plasmodium falciparum cytosolic glyoxalase II 0.0048 0.0238 0.0353
Brugia malayi metallo-beta-lactamase superfamily protein 0.0048 0.0238 0.0224
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.084 0.5839 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0385 0.2622 0.2612
Schistosoma mansoni protein farnesyltransferase subunit beta 0.084 0.5839 0.5839
Loa Loa (eye worm) hypothetical protein 0.0068 0.0383 0.0378
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0271 0.1819 0.1815
Schistosoma mansoni hypothetical protein 0.0048 0.0238 0.0238
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.084 0.5839 1
Onchocerca volvulus 0.0432 0.2953 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0032 0.0027
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0048 0.0238 0.0294
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0271 0.1819 0.3077
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0037 0.0164 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Plasmodium vivax prenyltransferase alpha subunit, putative 0.049 0.3365 0.574
Schistosoma mansoni neprilysin 0.0024 0.0071 0.0071
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0014 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0224 0.0219
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0032 0.0018
Echinococcus granulosus neuropeptide receptor 0.0016 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0037 0.0164 0.0164
Mycobacterium tuberculosis Probable conserved membrane protein 0.0037 0.0164 0.0187
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0033 0.0002
Trichomonas vaginalis beta lactamase domain, putative 0.0048 0.0238 0.0355
Schistosoma mansoni peptidyl-glycine monooxygenase 0.1429 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Trypanosoma cruzi lanosterol synthase, putative 0.1006 0.701 1
Leishmania major hypothetical protein, conserved 0.0229 0.1516 0.2554
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0014 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0037 0.0164 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0271 0.1819 0.2559
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0168 0.0234
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.049 0.3365 0.5741
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0032 0.0032
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0014 0.0014
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0032 0.0032
Leishmania major squalene synthase, putative 0.0733 0.5083 0.8699
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0048 0.0238 0.0355
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0605 0.4177 0.4169
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0192 0.0274
Brugia malayi hypothetical protein 0.0019 0.0032 0.0018
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0759 0.5264 0.5257
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0372 0.2529 0.43
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0271 0.1819 0.1807
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0372 0.2529 0.2518
Mycobacterium ulcerans phytoene synthase, CrtB 0.0229 0.1516 1
Echinococcus granulosus allatostatin A receptor 0.0016 0.0014 0.0009
Schistosoma mansoni neuropeptide receptor 0.0016 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.0016 0.0014 0.0014
Brugia malayi peptidase family M13 containing protein 0.0023 0.0059 0.0045
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.049 0.3365 0.3362
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0238 0.0233
Schistosoma mansoni hypothetical protein 0.0048 0.0238 0.0238
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0014 0.0009
Entamoeba histolytica alkyl sulfatase, putative 0.0048 0.0238 0.0355
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0014 0.0009
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0014 0.0014
Echinococcus granulosus serotonin receptor 0.0016 0.0014 0.0009
Echinococcus granulosus sex peptide receptor 0.0016 0.0014 0.0009
Giardia lamblia Hypothetical protein 0.0037 0.0164 0.0225
Echinococcus granulosus tripartite motif containing protein 3 0.0037 0.0164 0.0159
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0071
Brugia malayi ethe1-prov protein 0.0048 0.0238 0.0224
Leishmania major metallo-beta-lactamase family-like protein 0.0048 0.0238 0.0353
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0098 0.0093
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.084 0.5839 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0032 0.0032
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0014 0.0009
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0605 0.4177 0.4177
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0238 0.0355
Giardia lamblia Prenyltransferase 0.084 0.5839 1
Plasmodium vivax geranylgeranyltransferase, putative 0.0271 0.1819 0.3076
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0048 0.0238 0.0294
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0014 0.0014
Schistosoma mansoni zinc phosphodiesterase 0.0048 0.0238 0.0238
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0192 0.0276
Brugia malayi Pre-SET motif family protein 0.0029 0.0106 0.0092
Brugia malayi B-box zinc finger family protein 0.0037 0.0164 0.015
Trypanosoma cruzi phytoene synthase, putative 0.0229 0.1516 0.2125
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0271 0.1819 0.3076
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0032 0.0027
Onchocerca volvulus 0.0372 0.2529 0.8556
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.1429 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0106 0.0125
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0605 0.4177 0.4174
Chlamydia trachomatis ribonuclease Z 0.0048 0.0238 0.5
Leishmania major hypothetical protein, conserved 0.0048 0.0238 0.0353
Mycobacterium tuberculosis Conserved protein 0.0048 0.0238 0.0294
Echinococcus granulosus g protein coupled receptor 0.0016 0.0014 0.0009
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0032 0.0018
Mycobacterium ulcerans hydrolase 0.0048 0.0238 0.1383
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.084 0.5839 1
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0037 0.0164 0.0187
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0355 0.0341
Trichomonas vaginalis beta lactamase domain, putative 0.0048 0.0238 0.0355
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0032 0.0027
Loa Loa (eye worm) hypothetical protein 0.007 0.0395 0.039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0372 0.2529 0.2525
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0372 0.2529 0.4299
Trypanosoma cruzi protein farnesyltransferase, putative 0.084 0.5839 0.8321
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.084 0.5839 0.5833
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0372 0.2529 0.2525
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0032 0.0018
Brugia malayi B-box type zinc-finger protein ncl-1 0.0037 0.0164 0.015
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0071
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.119 0.1186
Echinococcus granulosus microtubule associated protein 2 0.0673 0.4657 0.4654
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0271 0.1819 0.1819
Schistosoma mansoni adenoreceptor 0.0016 0.0014 0.0014
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0355 0.0355
Schistosoma mansoni hypothetical protein 0.0048 0.0238 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0238 0.0355
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0048 0.0238 0.0233
Trypanosoma cruzi glyoxalase II 0.0048 0.0238 0.0294
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.4657 0.4657
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0229 0.1516 0.1516
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0014 0.0009
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0355 0.035
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0271 0.1819 0.1807
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) B-box zinc finger family protein 0.0037 0.0164 0.0159
Mycobacterium ulcerans hydrolase 0.0048 0.0238 0.1383
Loa Loa (eye worm) hypothetical protein 0.007 0.0395 0.039
Onchocerca volvulus 0.0048 0.0238 0.0762
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0048 0.0238 0.0233
Giardia lamblia Rab geranylgeranyltransferase 0.049 0.3365 0.574
Echinococcus multilocularis endothelin converting enzyme 1 0.0093 0.0554 0.054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0224 0.021
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0374 0.2542 0.2531
Brugia malayi Angiotensin-converting enzyme family protein 0.0607 0.4193 0.4185
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0048 0.0238 0.0355
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0014 0.0009
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0048 0.0238 0.0224
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0048 0.0238 0.0353
Mycobacterium ulcerans glyoxalase II, GloB 0.0048 0.0238 0.1383
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) fli-1 protein 0.022 0.1457 0.1453
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0032 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0224 0.021
Leishmania major farnesyltransferase beta subunit 0.084 0.5839 1
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0014 0.0009
Mycobacterium tuberculosis Possible hydrolase 0.0048 0.0238 0.0294
Mycobacterium ulcerans hypothetical protein 0.0048 0.0238 0.1383
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.1006 0.701 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS18 0.0037 0.0164 0.0187
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0605 0.4177 0.4169
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0032 0.0018
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0355 0.035
Giardia lamblia Rab geranylgeranyltransferase 0.0372 0.2529 0.4299
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.1429 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0224 0.0224
Trichomonas vaginalis beta lactamase domain, putative 0.0048 0.0238 0.0355
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0106 0.0092
Loa Loa (eye worm) hypothetical protein 0.0093 0.0554 0.0549
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0071
Echinococcus granulosus protein farnesyltransferase subunit beta 0.084 0.5839 0.5836
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Schistosoma mansoni neuropeptide receptor 0.0016 0.0014 0.0014
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0048 0.0238 0.0353
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0271 0.1819 0.2559
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0048 0.0238 0.0294
Giardia lamblia Rab geranylgeranyltransferase 0.0271 0.1819 0.3076
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0032 0.0027
Schistosoma mansoni hypothetical protein 0.0037 0.0164 0.0164
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0023 0.0059 0.0059
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0215 0.021
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0059 0.0059
Loa Loa (eye worm) zinc metallopeptidase 4 0.0023 0.0059 0.0054
Schistosoma mansoni dopamine-beta-monooxygenase 0.0759 0.5264 0.5264
Loa Loa (eye worm) hypothetical protein 0.007 0.0395 0.039
Schistosoma mansoni biogenic amine receptor 0.0016 0.0014 0.0014
Brugia malayi hypothetical protein 0.0048 0.0238 0.0224
Brugia malayi PXA domain containing protein 0.0019 0.0032 0.0018
Echinococcus granulosus endothelin converting enzyme 1 0.0093 0.0554 0.0549
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0033 0.0019
Loa Loa (eye worm) B-box zinc finger family protein 0.0037 0.0164 0.0159
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0032 0.0018
Loa Loa (eye worm) hypothetical protein 0.0229 0.1516 0.1511
Echinococcus granulosus expressed protein 0.0364 0.2473 0.2469
Echinococcus multilocularis ETHE1 protein 0.0048 0.0238 0.0224
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0355 0.0554
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Brugia malayi B-box type zinc-finger protein ncl-1 0.0037 0.0164 0.015
Plasmodium falciparum geranylgeranyltransferase, putative 0.0271 0.1819 0.3076
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0032 0.0018
Mycobacterium tuberculosis Conserved protein 0.0048 0.0238 0.0294
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0014 0.0009
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0037 0.0164 0.0164
Mycobacterium ulcerans hypothetical protein 0.0048 0.0238 0.1383
Brugia malayi Ets-domain containing protein 0.0073 0.0413 0.0399
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0413 0.0408
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0027
Schistosoma mansoni peptidylglycine monooxygenase 0.0759 0.5264 0.5264
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Onchocerca volvulus 0.0046 0.0224 0.0713
Entamoeba histolytica metallo-beta-lactamase family protein 0.0048 0.0238 0.0355
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0032 0.0018
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0048 0.0238 0.0233
Loa Loa (eye worm) hypothetical protein 0.0039 0.0173 0.0168
Mycobacterium tuberculosis Beta lactamase like protein 0.0048 0.0238 0.0294
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0106 0.0106
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0014 0.0009
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0032 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Schistosoma mansoni biogenic amine receptor 0.0016 0.0014 0.0014
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.0033
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0032 0.0032
Schistosoma mansoni peptidylglycine monooxygenase 0.0037 0.0164 0.0164
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0048 0.0238 0.0353
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.002
Echinococcus multilocularis Protein lozenge 0.0054 0.0283 0.0269
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0413 0.0408
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0032 0.0018
Entamoeba histolytica alkyl sulfatase, putative 0.0048 0.0238 0.0355
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0192 0.0274
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0238 0.0355
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0032 0.0027
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0048 0.0238 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0238 0.0355
Leishmania major geranylgeranyltransferase, putative 0.0271 0.1819 0.3076
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0271 0.1819 0.3077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Trypanosoma cruzi squalene synthase, putative 0.0733 0.5083 0.7239
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0229 0.1516 0.5108
Echinococcus multilocularis Squalene phytoene synthase 0.0229 0.1516 0.1503
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0032 0.0027
Trypanosoma cruzi squalene synthase, putative 0.0733 0.5083 0.7239
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0522 0.3588 0.3579
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0048 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0372 0.2529 0.2525
Echinococcus granulosus tm gpcr rhodopsin 0.0522 0.3588 0.3585
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0192 0.0187
Echinococcus granulosus roundabout 2 0.0018 0.0025 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Entamoeba histolytica type A flavoprotein, putative 0.0048 0.0238 0.0355
Mycobacterium tuberculosis Conserved protein 0.0048 0.0238 0.0294
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0238 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0238 0.0355
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.023 0.023
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0372 0.2529 0.3577
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0023 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0027
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0032 0.0027
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0032 0.0018
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.049 0.3365 0.3362
Mycobacterium ulcerans zinc metalloprotease 0.0093 0.0554 0.3513
Trypanosoma cruzi glyoxalase II 0.0048 0.0238 0.0294
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0014 0.0009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0866 0.0862
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0032 0.0032
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0605 0.4177 0.4174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0224 0.0224
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0032 0.0018
Mycobacterium leprae probable zinc metalloprotease 0.0093 0.0554 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0014 0.0014
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0048 0.0238 0.0294
Leishmania major metallo-beta-lactamase family protein-like protein 0.0048 0.0238 0.0353
Brugia malayi Hypothetical RING finger protein F54G8.4 in chromosome III 0.0037 0.0164 0.015
Loa Loa (eye worm) hypothetical protein 0.0432 0.2953 0.295
Loa Loa (eye worm) hypothetical protein 0.0048 0.0238 0.0233
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0093 0.0554 0.054
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0238 0.0233
Toxoplasma gondii hypothetical protein 0.0372 0.2529 0.4299
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Brugia malayi hypothetical protein 0.0019 0.0032 0.0018
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0894 0.0894
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.049 0.3365 0.3356
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0033 0.0028
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.084 0.5839 0.5833
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0048 0.0238 0.0353
Entamoeba histolytica metallo-beta-lactamase family protein 0.0048 0.0238 0.0355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0894 0.0881
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0048 0.0238 0.0233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0014 0.0014
Plasmodium vivax unspecified product 0.0048 0.0238 0.0353
Loa Loa (eye worm) hypothetical protein 0.0271 0.1819 0.1815
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0014 0.0014
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0014 0.0014
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.084 0.5839 1
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0048 0.0238 0.0353
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0014 0.0009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0224 0.0219
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Brugia malayi B-box zinc finger family protein 0.0037 0.0164 0.015
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.4657 0.4649
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0046 0.0224 0.0219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0238 0.0355
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0355 0.0461
Loa Loa (eye worm) hypothetical protein 0.0093 0.0554 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0032 0.0032
Schistosoma mansoni opsin-like receptor 0.0016 0.0014 0.0014
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0047 0.023 0.023
Echinococcus multilocularis tripartite motif containing protein 3 0.0037 0.0164 0.015
Trichomonas vaginalis beta lactamase domain, putative 0.0048 0.0238 0.0355
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0106 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Entamoeba histolytica hypothetical protein 0.0037 0.0164 0.0227
Echinococcus granulosus brain tumor protein 0.0037 0.0164 0.0159
Brugia malayi Pre-SET motif family protein 0.0203 0.1335 0.1322
Plasmodium vivax farnesyltransferase beta subunit, putative 0.084 0.5839 1
Schistosoma mansoni biogenic amine receptor 0.0016 0.0014 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0032 0.0032
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0033 0.0019
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0014 0.0009
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0048 0.0238 0.0294
Loa Loa (eye worm) hypothetical protein 0.0093 0.0554 0.0549
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.049 0.3365 0.574
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0168 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0027
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.084 0.5839 1
Toxoplasma gondii peptidase family M13 protein 0.0093 0.0554 0.0897
Echinococcus granulosus g protein coupled receptor 0.0016 0.0014 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0032 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0027
Echinococcus multilocularis brain tumor protein 0.0037 0.0164 0.015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Schistosoma mansoni hypothetical protein 0.0024 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0372 0.2529 0.4299
Schistosoma mansoni zinc phosphodiesterase 0.0048 0.0238 0.0238
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0215 0.0201
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0048 0.0238 0.0233
Loa Loa (eye worm) NCL-1 protein 0.0037 0.0164 0.0159
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0372 0.2529 0.43
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0032 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0014 0.0009
Brugia malayi PXA domain containing protein 0.0019 0.0032 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0372 0.2529 0.3577
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0014 0.0009
Schistosoma mansoni opsin-like receptor 0.0016 0.0014 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0014 0.0014
Schistosoma mansoni amine GPCR 0.0016 0.0014 0.0014
Onchocerca volvulus Putative hydrolase PNKD 0.0048 0.0238 0.0762
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.1429 1 1
Leishmania major lanosterol synthase, putative 0.0734 0.5091 0.8713
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0048 0.0238 0.0353
Loa Loa (eye worm) hypothetical protein 0.049 0.3365 0.3362
Trypanosoma brucei squalene synthase, putative 0.0733 0.5083 0.7239
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0048 0.0238 0.0294
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0605 0.4177 0.4177
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0048 0.0238 0.0353
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0224 0.0224
Trichomonas vaginalis apoptosis inducing factor, putative 0.0048 0.0238 0.0355
Onchocerca volvulus 0.0167 0.1078 0.3619
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0224 0.021
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0014 0.0014
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0271 0.1819 0.3076
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0271 0.1819 0.2559
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.049 0.3365 0.5741
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.049 0.3365 0.5741
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0101
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.049 0.3365 0.3356
Loa Loa (eye worm) hypothetical protein 0.007 0.0395 0.039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Echinococcus granulosus hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1335 0.133
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0014 0.0009
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0032 0.0018
Schistosoma mansoni lozenge 0.0054 0.0283 0.0283
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0048 0.0238 0.0224
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0014 0.0014
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0014 0.0009
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0048 0.0238 0.0294
Loa Loa (eye worm) hypothetical protein 0.0432 0.2953 0.295
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Schistosoma mansoni amine GPCR 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Brugia malayi metallo-beta-lactamase superfamily protein 0.0048 0.0238 0.0224
Loa Loa (eye worm) hypothetical protein 0.0068 0.0383 0.0378
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0192 0.0274
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0159
Trypanosoma cruzi lanosterol synthase, putative 0.1006 0.701 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0032 0.0032
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0014 0.0009
Trichomonas vaginalis beta lactamase domain, putative 0.0048 0.0238 0.0355
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0372 0.2529 0.2529
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0014 0.0009
Schistosoma mansoni endothelin-converting enzyme-related 0.0023 0.0059 0.0059
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0023 0.0059 0.0059
Schistosoma mansoni amine GPCR 0.0016 0.0014 0.0014
Echinococcus multilocularis expressed protein 0.0364 0.2473 0.2462
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0355 0.0341
Echinococcus granulosus neuropeptide receptor 0.0016 0.0014 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0033 0.0002
Entamoeba histolytica type A flavoprotein, putative 0.0048 0.0238 0.0355
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0033 0.0028
Plasmodium vivax SET domain protein, putative 0.0029 0.0106 0.0125
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0106 0.0101
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0032 0.0018
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0014 0.0009
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.084 0.5839 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0192 0.0276
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0062 0.0338 0.0333
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0355 0.0461
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Mycobacterium ulcerans beta lactamase-like protein 0.0048 0.0238 0.1383
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0014 0.0009
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0014 0.0014
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0032 0.0027
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0383 0.0378
Echinococcus granulosus orexin receptor type 2 0.0016 0.0014 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0014 0.0009
Loa Loa (eye worm) runx1 0.0054 0.0283 0.0278
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0032 0.0018
Loa Loa (eye worm) hypothetical protein 0.0068 0.0383 0.0378
Loa Loa (eye worm) hypothetical protein 0.0037 0.0164 0.0159
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0014 0.0009
Plasmodium falciparum protein farnesyltransferase subunit beta 0.084 0.5839 1
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0372 0.2529 0.3577
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0048 0.0238 0.1383
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0014 0.0009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0238 0.0233
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS17 0.0037 0.0164 0.0187
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0048 0.0238 0.0233
Mycobacterium ulcerans hypothetical protein 0.0048 0.0238 0.1383
Brugia malayi hypothetical protein 0.0432 0.2953 0.2943
Loa Loa (eye worm) acetyltransferase 0.0141 0.0894 0.0889
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Onchocerca volvulus 0.0048 0.0238 0.0762
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0271 0.1819 0.3076
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0215 0.0201
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0238 0.0294
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Loa Loa (eye worm) RING finger protein nhl-1 0.0037 0.0164 0.0159
Schistosoma mansoni neuropeptide receptor 0.0016 0.0014 0.0014
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0014 0.0014
Echinococcus granulosus somatostatin receptor 0.0016 0.0014 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.119 0.1178
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0048 0.0238 1
Trypanosoma brucei glyoxalase II 0.0048 0.0238 0.0294
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0032 0.0018
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0372 0.2529 0.3577
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0014 0.0009
Giardia lamblia Haloacid dehalogenase-like hydrolase family 0.0037 0.0164 0.0225
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0607 0.4193 0.419
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0009
Echinococcus granulosus zinc phosphodiesterase 0.0048 0.0238 0.0233
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0032 0.0018
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0014 0.0009
Schistosoma mansoni ets-related 0.022 0.1457 0.1457
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0229 0.1516 0.2125
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0244 0.0244
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0032 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Schistosoma mansoni gabp alpha 0.0073 0.0413 0.0413
Mycobacterium tuberculosis Possible hydrolase 0.0048 0.0238 0.0294
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0605 0.4177 0.7139
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0238 0.0294
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0014 0.0014
Mycobacterium ulcerans hydrolase 0.0048 0.0238 0.1383
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.1105 0.3712
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0014 0.0014
Trichomonas vaginalis beta lactamase domain, putative 0.0048 0.0238 0.0355
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0048 0.0238 0.0353
Brugia malayi Fli-1 protein 0.022 0.1457 0.1445
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0271 0.1819 0.3077

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 nM Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot ChEMBL. 17425296
IC50 (functional) = 10 nM Inhibition of VEGF-induced phosphorylation of human KDR expressed in mouse NIH3T3 cell line by Western blot ChEMBL. 17425296
IC50 (binding) = 24 nM Inhibition of human KDR kinase by HTRF assay ChEMBL. 17425296
IC50 (binding) = 24 nM Inhibition of human KDR kinase by HTRF assay ChEMBL. 17425296
IC50 (binding) > 10 uM Displacement of [3H]dofetilide from hERG expressed in HEK293 cells ChEMBL. 17425296
IC50 (binding) > 10 uM Displacement of [3H]dofetilide from hERG expressed in HEK293 cells ChEMBL. 17425296

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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