Detailed information for compound 45448

Basic information

Technical information
  • TDR Targets ID: 45448
  • Name: (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2- yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2- amino-3-(4-hydroxyphenyl)propanoyl]amino]prop anoyl]amino]-3-phenylpropanoyl]amino]acetyl]a mino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidin e-2-carboxamide
  • MW: 802.873 | Formula: C40H50N8O10
  • H donors: 10 H acceptors: 10 LogP: 0.02 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)C)Cc1ccccc1
  • InChi: 1S/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29-,30-,31-,32-,33-/m0/s1
  • InChiKey: FHZPGIUBXYVUOY-XDGMXVDYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-N-[(1S)-2-amino-1-(hydroxymethyl)-2-oxo-ethyl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
  • (2S)-N-[(1S)-2-amino-1-(hydroxymethyl)-2-oxoethyl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-1-oxopropyl]amino]-1-oxo-3-phenylpropyl]amino]-1-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]-2-pyrrolidinecarboxamide
  • (2S)-N-[(2S)-1-azanyl-3-hydroxy-1-oxo-propan-2-yl]-1-[(2S)-2-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]ethanoylamino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
  • (2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-2-amino-2-keto-1-methylol-ethyl]pyrrolidine-2-carboxamide
  • dermorphin
  • (2S)-N-[(2S)-1-amino-3-hydroxy-1-oxo-propan-2-yl]-1-[(2S)-2-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]ethanoylamino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE HYDROLASE 0.3005 0.1814 1
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0319 0.0179 0.0306
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0319 0.0179 0.0306
Schistosoma mansoni topbp1 0.0031 0.0004 0.0006
Trypanosoma brucei adenosine kinase, putative 0.0084 0.0036 0.0813
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.0299 0.0167 0.0167
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0075 0.003 0.0041
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0056 0.0056
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0345 0.0195 0.0195
Onchocerca volvulus 0.0081 0.0034 0.0103
Brugia malayi G-protein coupled receptor 0.0078 0.0032 0.0032
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0072 0.0393
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.0031 0.0042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0299 0.0167 0.0226
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0076 0.0031 0.0042
Onchocerca volvulus 0.0299 0.0167 0.0503
Schistosoma mansoni cpg binding protein 0.0064 0.0024 0.0041
Echinococcus granulosus transient receptor potential gamma protein 0.0076 0.0031 0.0042
Schistosoma mansoni hypothetical protein 0.0078 0.0032 0.0055
Onchocerca volvulus 0.0141 0.0071 0.0213
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.001 0.0013
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0141 0.0071 0.0121
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0141 0.0071 0.0213
Onchocerca volvulus 0.0141 0.0071 0.0213
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0372 0.0211 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0021 0.0036
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0075 0.003 0.003
Brugia malayi cation channel family protein 0.0076 0.0031 0.0031
Schistosoma mansoni ryanodine receptor related 0.0076 0.0031 0.0053
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0072 0.0379
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0343 0.0194 0.0194
Echinococcus granulosus Protein patched homolog 1 0.0041 0.001 0.0013
Echinococcus multilocularis adam 0.0336 0.0189 0.0256
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0051 0.0276
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0032 0.0044
Echinococcus granulosus two pore calcium channel protein 1 0.0076 0.0031 0.0042
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0078 0.0032 0.0044
Echinococcus granulosus serotonin receptor 0.0078 0.0032 0.0044
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0004 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0032 0.0055
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0012 0.0255
Loa Loa (eye worm) hypothetical protein 0.0123 0.006 0.006
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.2019 0.1214 0.2081
Loa Loa (eye worm) latrophilin receptor protein 2 0.0172 0.0089 0.0089
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0078 0.0032 0.0055
Echinococcus multilocularis tumor protein p63 0.0343 0.0194 0.0263
Loa Loa (eye worm) kelch domain-containing protein family protein 0.2531 0.1525 0.1525
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0056 0.2768
Onchocerca volvulus 0.0075 0.003 0.0091
Echinococcus granulosus neuropeptide receptor A26 0.0078 0.0032 0.0044
Onchocerca volvulus 0.0078 0.0032 0.0097
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0158 0.0081 0.0139
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0299 0.0167 0.0226
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0158 0.0081 0.0081
Schistosoma mansoni adenosine kinase 0.0084 0.0036 0.0062
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0006 0.0008
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0081 0.0034 0.0046
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0075 0.003 0.1441
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.211 0.1269 0.1721
Brugia malayi CHE-14 protein 0.0041 0.001 0.001
Onchocerca volvulus 0.0075 0.003 0.0091
Schistosoma mansoni nAChR subunit 0.0081 0.0034 0.0058
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Onchocerca volvulus Putative nachr subunit 0.0081 0.0034 0.0103
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0019 0.0085
Loa Loa (eye worm) hypothetical protein 0.0158 0.0081 0.0081
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0075 0.003 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0107 0.005 0.2903
Brugia malayi Nuclear hormone receptor-like 1 0.0299 0.0167 0.0167
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0004 0.0005
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0319 0.0179 0.0306
Onchocerca volvulus Huntingtin homolog 0.0123 0.006 0.018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.0164 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0051 0.0276
Brugia malayi nuclear hormone receptor 0.0141 0.0071 0.0071
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0032 0.0055
Leishmania major carbonic anhydrase-like protein 0.0734 0.0431 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0076 0.0031 0.0031
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Echinococcus granulosus GPCR family 2 0.0172 0.0089 0.0121
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Brugia malayi Cyclic-nucleotide gated cation channel 0.0076 0.0031 0.0031
Echinococcus multilocularis voltage dependent calcium channel 0.0076 0.0031 0.0042
Echinococcus multilocularis protein dispatched 1 0.0047 0.0013 0.0018
Brugia malayi hypothetical protein 0.0107 0.005 0.005
Loa Loa (eye worm) matrix metalloproteinase 0.2468 0.1486 0.1486
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.0031 0.0042
Echinococcus multilocularis fibrillin 1 0.0336 0.0189 0.0256
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0076 0.0031 0.1468
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0172 0.0089 0.0153
Schistosoma mansoni amine GPCR 0.0078 0.0032 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0299 0.0167 0.0226
Echinococcus granulosus hypothetical protein 0.0078 0.0032 0.0044
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0012 0.0255
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.0042
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0189 0.01 0.0135
Echinococcus multilocularis neuropeptide FF receptor 2 0.0078 0.0032 0.0044
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0051 0.0261
Echinococcus granulosus adam 0.0336 0.0189 0.0256
Brugia malayi Nuclear hormone receptor E75 0.0141 0.0071 0.0071
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Echinococcus granulosus G protein coupled receptor 139 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0109 0.0051 0.0051
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0158 0.0081 0.0081
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0075 0.003 0.0041
Echinococcus multilocularis dro:myosuppressin receptor 0.0078 0.0032 0.0044
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0081 0.0034 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0051 0.1793
Schistosoma mansoni hypothetical protein 0.004 0.0009 0.0015
Schistosoma mansoni hypothetical protein 0.004 0.0009 0.0015
Brugia malayi hypothetical protein 0.0037 0.0007 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Onchocerca volvulus 0.0109 0.0051 0.0153
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0007 0.0007
Echinococcus granulosus sodium leak channel non selective protein 0.0076 0.0031 0.0042
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0032 0.0044
Schistosoma mansoni hypothetical protein 0.0165 0.0085 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0013 0.0018
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0076 0.0031 0.0093
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0013 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0076 0.0031 0.0031
Brugia malayi neuropeptide F receptor 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.4674 0.2829 0.2829
Brugia malayi G protein-coupled receptor 0.0078 0.0032 0.0032
Schistosoma mansoni coup transcription factor 0.0299 0.0167 0.0286
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Toxoplasma gondii hypothetical protein 0.0345 0.0195 1
Brugia malayi voltage-dependent calcium channel 0.0076 0.0031 0.0031
Brugia malayi larval opioid receptor 0.0078 0.0032 0.0032
Brugia malayi hypothetical protein 0.0076 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0004 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0299 0.0167 0.0226
Brugia malayi nuclear receptor RXR 0.0141 0.0071 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Schistosoma mansoni voltage-gated potassium channel 0.015 0.0076 0.0131
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0075 0.003 0.003
Echinococcus multilocularis serotonin receptor 0.0078 0.0032 0.0044
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0076 0.0031 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Brugia malayi Matrixin family protein 0.2468 0.1486 0.1486
Schistosoma mansoni voltage-gated potassium channel 0.015 0.0076 0.0131
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0032 0.0044
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Echinococcus multilocularis potassium large conductance calcium activated 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Brugia malayi Adenosine kinase-like 0.0084 0.0036 0.0036
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0081 0.0034 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0464 0.0267 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0694 0.0407 0.223
Toxoplasma gondii hypothetical protein 0.0076 0.0031 0.1468
Loa Loa (eye worm) hypothetical protein 0.007 0.0027 0.0027
Onchocerca volvulus 0.0037 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.2531 0.1525 0.1525
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0172 0.0089 0.0121
Schistosoma mansoni amine GPCR 0.0078 0.0032 0.0055
Echinococcus multilocularis GPCR, family 2 0.0172 0.0089 0.0121
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0032 0.0032
Echinococcus multilocularis BTB:POZ domain containing protein 0.0075 0.003 0.0041
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0081 0.0034 0.0058
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0004 0.0055
Loa Loa (eye worm) hypothetical protein 0.0336 0.0189 0.0189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0034 0.0034
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.015 0.0076 0.0103
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0032 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0044 0.0011 0.0019
Echinococcus granulosus allatostatin A receptor 0.0078 0.0032 0.0044
Onchocerca volvulus 0.0464 0.0267 0.0806
Schistosoma mansoni thyroid hormone receptor 0.0299 0.0167 0.0286
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0044 0.0011 0.0011
Schistosoma mansoni transient receptor potential channel 0.0076 0.0031 0.0053
Entamoeba histolytica hypothetical protein 0.0107 0.005 0.2903
Schistosoma mansoni acetylcholine receptor-related 0.0037 0.0007 0.0013
Brugia malayi hypoxia-induced factor 1 0.0145 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Brugia malayi topoisomerase 0.0031 0.0004 0.0004
Schistosoma mansoni neuropeptide receptor 0.0988 0.0586 0.1004
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0076 0.0031 0.0093
Echinococcus granulosus g protein coupled receptor 0.0078 0.0032 0.0044
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0078 0.0032 0.0044
Toxoplasma gondii transporter, cation channel family protein 0.0076 0.0031 0.1468
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0037 0.0007 0.001
Brugia malayi putative neuropeptide receptor NPR1 0.0078 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0299 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0299 0.0167 0.0286
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0051 0.1161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0544 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Echinococcus granulosus g-protein coupled receptor 0.0078 0.0032 0.0044
Brugia malayi orphan nuclear receptor NR2E1 0.0141 0.0071 0.0071
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Nuclear hormone receptor-like 1 0.0158 0.0081 0.0081
Echinococcus multilocularis snurportin 1 0.0313 0.0175 0.0238
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1953 0.1173 0.1592
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Onchocerca volvulus 0.0075 0.003 0.0091
Echinococcus granulosus carbonic anhydrase 0.0345 0.0195 0.0264
Onchocerca volvulus 0.0076 0.0031 0.0093
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0004 0.0004
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0004 0.0006
Giardia lamblia High cysteine protein 0.0336 0.0189 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0031 0.0053
Echinococcus granulosus glycine receptor subunit alpha 1 0.0081 0.0034 0.0046
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0006 0.0028
Trichomonas vaginalis esterase, putative 0.0109 0.0051 0.1793
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0032 0.0044
Echinococcus granulosus fibrillin 1 0.0336 0.0189 0.0256
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0076 0.0031 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0032 0.0044
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) ACC-1 protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.003 0.0052
Echinococcus granulosus potassium voltage gated channel protein 0.0076 0.0031 0.0042
Schistosoma mansoni transient receptor potential channel 0.0076 0.0031 0.0053
Schistosoma mansoni hypothetical protein 0.0076 0.0031 0.0053
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0034 0.0034
Toxoplasma gondii kinase, pfkB family protein 0.0084 0.0036 0.1736
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.003 0.0052
Mycobacterium tuberculosis Conserved protein 0.0109 0.0051 0.0261
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Onchocerca volvulus Protein ultraspiracle homolog 0.0299 0.0167 0.0503
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0019 0.0026
Schistosoma mansoni lipoxygenase 0.0057 0.002 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0078 0.0032 0.0044
Brugia malayi GnHR receptor homolog 0.0078 0.0032 0.0032
Brugia malayi steroid hormone receptor 0.0299 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0109 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.4573 0.2768 0.2768
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0075 0.003 0.0052
Echinococcus granulosus tm gpcr rhodopsin 0.0078 0.0032 0.0044
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0141 0.0071 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0075 0.003 0.003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0004 0.006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0299 0.0167 0.0167
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0003 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0299 0.0167 0.0167
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0076 0.0031 0.0031
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Brugia malayi Integrin alpha cytoplasmic region family protein 0.4573 0.2768 0.2768
Leishmania major hypothetical protein, conserved 0.0109 0.0051 0.1161
Echinococcus granulosus single minded 2 0.0035 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0015 0.0015
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0076 0.0031 0.0042
Brugia malayi EGF-like domain containing protein 0.0336 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Brugia malayi hypothetical protein 0.0123 0.006 0.006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0299 0.0167 0.0167
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0076 0.0031 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0031 0.0054
Schistosoma mansoni growth hormone secretagogue receptor 0.0078 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Brugia malayi RE15519p 0.0078 0.0032 0.0032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0299 0.0167 0.0226
Leishmania major hypothetical protein, conserved 0.0075 0.003 0.0681
Schistosoma mansoni nAChR subunit 0.0081 0.0034 0.0058
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0345 0.0195 0.0195
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0078 0.0032 0.0055
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0078 0.0032 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0299 0.0167 0.0286
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0078 0.0032 0.0032
Schistosoma mansoni nAChR subunit 0.0081 0.0034 0.0058
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0044 0.0011 0.0011
Echinococcus multilocularis nAChR subunit 0.0044 0.0011 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0141 0.0071 0.0071
Trypanosoma cruzi potassium voltage-gated channel 0.0075 0.003 0.0681
Schistosoma mansoni steroid hormone receptor ad4bp 0.0299 0.0167 0.0286
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Schistosoma mansoni transient receptor potential channel 0.0076 0.0031 0.0053
Echinococcus multilocularis ankyrin repeat protein 0.0161 0.0083 0.0113
Schistosoma mansoni calcium-activated potassium channel 0.0076 0.0031 0.0053
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0078 0.0032 0.0044
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0075 0.003 0.1441
Leishmania major hypothetical protein, conserved 0.0076 0.0031 0.0693
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0081 0.0034 0.0034
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0032 0.0055
Onchocerca volvulus 0.0078 0.0032 0.0097
Schistosoma mansoni hypothetical protein 0.0172 0.0089 0.0153
Plasmodium vivax SET domain protein, putative 0.006 0.0021 0.3814
Loa Loa (eye worm) hypothetical protein 0.0158 0.0081 0.0081
Plasmodium falciparum kelch protein K13 0.0075 0.003 0.1441
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0076 0.0031 0.0042
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor 0.0141 0.0071 0.0071
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0081 0.0034 0.0046
Echinococcus multilocularis expressed conserved protein 0.009 0.004 0.0054
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.0053
Echinococcus granulosus transient receptor potential cation channel 0.0237 0.0129 0.0175
Schistosoma mansoni integrin beta subunit 0.9608 0.5832 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0012 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0031 0.0004 0.0015
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0081 0.0034 0.0046
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0078 0.0032 0.0044
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0076 0.0031 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0013 0.0018
Echinococcus granulosus tachykinin peptides receptor 99D 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Giardia lamblia Tenascin-37 0.0336 0.0189 1
Schistosoma mansoni nAChR subunit 0.0081 0.0034 0.0058
Echinococcus multilocularis glycine receptor subunit beta 0.0081 0.0034 0.0046
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0051 0.0261
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0075 0.003 0.003
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.003 0.003
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0081 0.0034 0.0058
Brugia malayi RNA recognition motif domain containing protein 0.0319 0.0179 0.0179
Loa Loa (eye worm) ion channel NompC 0.0076 0.0031 0.0031
Echinococcus multilocularis tar DNA binding protein 0.0319 0.0179 0.0242
Schistosoma mansoni nAChR subunit 0.0081 0.0034 0.0058
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0081 0.0034 0.0046
Schistosoma mansoni hypothetical protein 0.0078 0.0032 0.0055
Echinococcus granulosus thyroid hormone receptor alpha 0.0141 0.0071 0.0096
Echinococcus granulosus dnaJ subfamily B 0.0843 0.0498 0.0675
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi tailless protein 0.0141 0.0071 0.0071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0172 0.0089 0.0121
Brugia malayi conserved hypotetical protein 0.0141 0.0071 0.0071
Echinococcus granulosus integrin alpha ps 0.3798 0.2296 0.3114
Onchocerca volvulus 0.0078 0.0032 0.0097
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.0053
Schistosoma mansoni hypothetical protein 0.0843 0.0498 0.0854
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.0007 0.0007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0141 0.0071 0.0096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0299 0.0167 0.0286
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0044 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0075 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus granulosus 7tm_1 domain containing protein 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0158 0.0081 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Echinococcus granulosus hyperpolarization activated cyclic 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0345 0.0195 0.0195
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0299 0.0167 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0299 0.0167 0.0226
Echinococcus multilocularis two pore calcium channel protein 2 0.0076 0.0031 0.0042
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.0031 0.0042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0006 0.0009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0078 0.0032 0.0055
Schistosoma mansoni voltage-gated potassium channel 0.015 0.0076 0.0131
Brugia malayi EGF-like domain containing protein 0.0336 0.0189 0.0189
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0076 0.0031 0.0031
Echinococcus granulosus orexin receptor type 2 0.0078 0.0032 0.0044
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.0042
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0081 0.0034 0.0034
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0075 0.003 0.0681
Echinococcus multilocularis sodium channel protein 0.0189 0.01 0.0135
Schistosoma mansoni neuropeptide F-like receptor 0.0078 0.0032 0.0055
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0345 0.0195 0.0195
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Echinococcus granulosus snurportin 1 0.0313 0.0175 0.0238
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0734 0.0431 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0081 0.0034 0.0058
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0081 0.0034 0.0034
Echinococcus granulosus peptide allatostatin:somatostatin 0.0078 0.0032 0.0044
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0076 0.0031 0.0053
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0161 0.0083 0.0142
Onchocerca volvulus 0.0037 0.0007 0.0023
Brugia malayi Angiotensin-converting enzyme family protein 0.0158 0.0081 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0034 0.0034
Echinococcus granulosus glycine receptor subunit beta 0.0081 0.0034 0.0046
Brugia malayi Serotonin receptor 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0336 0.0189 0.0189
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0078 0.0032 0.0055
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.3005 0.1814 0.1814
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.003 0.003
Echinococcus multilocularis transient receptor potential cation channel 0.0237 0.0129 0.0175
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0004 0.0065
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Pre-SET motif family protein 0.006 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0109 0.0051 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Echinococcus multilocularis potassium voltage gated channel protein 0.015 0.0076 0.0103
Brugia malayi Cation transporter family protein 0.0081 0.0034 0.0034
Brugia malayi PAS domain containing protein 0.0047 0.0013 0.0013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0004
Echinococcus multilocularis g-protein coupled receptor 0.0078 0.0032 0.0044
Onchocerca volvulus 0.0078 0.0032 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0299 0.0167 0.0167
Brugia malayi Dopamine receptor protein 2 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0107 0.005 0.2903
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0319 0.0179 0.0306
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Echinococcus granulosus FTZ F1 alpha 0.0299 0.0167 0.0226
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.001 0.001
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.0042
Schistosoma mansoni hypothetical protein 0.004 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Brugia malayi EGF-like domain containing protein 0.0336 0.0189 0.0189
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0076 0.0031 0.0042
Echinococcus granulosus adenosine kinase 0.0084 0.0036 0.0049
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.0031 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0299 0.0167 0.0167
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0076 0.0031 0.0031
Loa Loa (eye worm) beta-lactamase 0.0109 0.0051 0.0051
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0032 0.0055
Schistosoma mansoni voltage-dependent calcium channel 0.0076 0.0031 0.0053
Echinococcus multilocularis transfer RNA-Gly 0.015 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0051 0.1793
Schistosoma mansoni nuclear hormone receptor 0.0141 0.0071 0.0121
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0081 0.0034 0.0034
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0141 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0075 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0158 0.0081 0.0081
Schistosoma mansoni carbonic anhydrase-related 0.0345 0.0195 0.0334
Mycobacterium tuberculosis Conserved protein 0.0109 0.0051 0.0261
Echinococcus multilocularis integrin alpha ps 0.3798 0.2296 0.3114
Brugia malayi ecdysteroid receptor 0.0299 0.0167 0.0167
Brugia malayi Dopamine receptor 0.0078 0.0032 0.0032
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0076 0.0031 0.0042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.003 0.0052
Schistosoma mansoni vesicular amine transporter 0.015 0.0076 0.0131
Loa Loa (eye worm) hypothetical protein 0.0075 0.003 0.003
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0037 0.0007 0.0007
Echinococcus multilocularis serotonin receptor 0.0078 0.0032 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.001 0.0235
Onchocerca volvulus 0.0081 0.0034 0.0103
Toxoplasma gondii hypothetical protein 0.0076 0.0031 0.1468
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0031 0.0053
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0078 0.0032 0.0055
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0081 0.0034 0.0058
Echinococcus multilocularis neuropeptide receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.0299 0.0167 0.0167
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0078 0.0032 0.0032
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0299 0.0167 0.0286
Echinococcus granulosus voltage gated hydrogen channel 1 0.0076 0.0031 0.0042
Onchocerca volvulus 0.0078 0.0032 0.0097
Schistosoma mansoni bromodomain containing protein 0.0066 0.0025 0.0043
Onchocerca volvulus 0.0081 0.0034 0.0103
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.0053
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0012 0.0313
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Echinococcus multilocularis geminin 0.0165 0.0085 0.0116
Brugia malayi nuclear receptor NHR-67 0.0141 0.0071 0.0071
Schistosoma mansoni nuclear receptor 0.0141 0.0071 0.0121
Echinococcus granulosus tumor protein p63 0.0343 0.0194 0.0263
Brugia malayi mKIAA0176 protein 0.0075 0.003 0.003
Schistosoma mansoni carbonic anhydrase-related 0.0345 0.0195 0.0334
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.2468 0.1486 0.1486
Echinococcus multilocularis shaker cognate 0.015 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.3005 0.1814 0.1814
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0081 0.0034 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0141 0.0071 0.0096
Echinococcus granulosus glycine receptor subunit alpha 1 0.0081 0.0034 0.0046
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0076 0.0031 0.0042
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0172 0.0089 0.0121
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Schistosoma mansoni microtubule-associated protein tau 0.211 0.1269 0.2176
Toxoplasma gondii ABC1 family protein 0.0109 0.0051 0.2516
Echinococcus multilocularis G protein coupled receptor 139 0.0988 0.0586 0.0795
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.0032 0.0055
Schistosoma mansoni opsin-like receptor 0.0078 0.0032 0.0055
Echinococcus multilocularis neuropeptide receptor A26 0.0078 0.0032 0.0044
Brugia malayi nuclear hormone receptor 0.0299 0.0167 0.0167
Schistosoma mansoni nuclear receptor nhr-48 0.0141 0.0071 0.0121
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Echinococcus granulosus sex peptide receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0158 0.0081 0.0081
Brugia malayi beta-lactamase family protein 0.0109 0.0051 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0172 0.0089 0.0089
Onchocerca volvulus Matrix metalloproteinase homolog 0.5473 0.3315 1
Schistosoma mansoni hypothetical protein 0.0345 0.0195 0.0334
Schistosoma mansoni inositol monophosphatase 0.0045 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.2468 0.1486 0.1486
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0078 0.0032 0.0032
Loa Loa (eye worm) matrixin family protein 0.5967 0.3616 0.3616
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0345 0.0195 0.0195
Schistosoma mansoni importin beta-1 0.0029 0.0003 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Brugia malayi ecdysone receptor 0.0141 0.0071 0.0071
Brugia malayi CXXC zinc finger family protein 0.0059 0.0021 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0158 0.0081 0.0081
Loa Loa (eye worm) TAR-binding protein 0.0319 0.0179 0.0179
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0044 0.0076
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0012 0.0484
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0004 0.0065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus granulosus nAChR subunit 0.0081 0.0034 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0299 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0044 0.0011 0.0479
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0032 0.0044
Echinococcus multilocularis protein jagged 2 0.0336 0.0189 0.0256
Schistosoma mansoni voltage-gated potassium channel 0.015 0.0076 0.0131
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0076 0.0031 0.0042
Onchocerca volvulus 0.0075 0.003 0.0091
Onchocerca volvulus 0.0109 0.0051 0.0153
Echinococcus granulosus carbonic anhydrase II 0.0734 0.0431 0.0585
Brugia malayi Transient-receptor-potential like protein 0.0076 0.0031 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.003 0.0052
Schistosoma mansoni cpg binding protein 0.0059 0.0021 0.0036
Schistosoma mansoni integrin alpha 0.8472 0.514 0.8814
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0544 0.0316 0.0316
Onchocerca volvulus 0.0081 0.0034 0.0103
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0076 0.0031 0.0031
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0081 0.0034 0.0046
Echinococcus granulosus fmrfamide receptor 0.0078 0.0032 0.0044
Echinococcus multilocularis carbonic anhydrase 0.0345 0.0195 0.0264
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0075 0.003 0.003
Echinococcus multilocularis g protein coupled receptor 0.0078 0.0032 0.0044
Brugia malayi hypothetical protein 0.0158 0.0081 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0299 0.0167 0.0226
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0158 0.0081 0.0139
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Schistosoma mansoni nAChR subunit 0.0037 0.0007 0.0013
Brugia malayi Matrixin family protein 0.2468 0.1486 0.1486
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0345 0.0195 0.0195
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0081 0.0034 0.0046
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0076 0.0031 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0299 0.0167 0.0167
Echinococcus multilocularis dnaJ subfamily B 0.0843 0.0498 0.0675
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0004 0.0065
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0076 0.0031 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Onchocerca volvulus 0.2468 0.1486 0.4483
Brugia malayi hypothetical protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0004 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Schistosoma mansoni hypothetical protein 0.0165 0.0085 0.0146
Loa Loa (eye worm) ryanodine receptor 0.0076 0.0031 0.0031
Echinococcus multilocularis G-protein coupled receptor, putative 0.0078 0.0032 0.0044
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0044 0.0011 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Echinococcus multilocularis integrin alpha ps 0.3798 0.2296 0.3114
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0 0.0001
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0336 0.0189 0.7034
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Onchocerca volvulus 0.0078 0.0032 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0004 0.0055
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0299 0.0167 0.0167
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.0042
Loa Loa (eye worm) melatonin receptor type 1A 0.0078 0.0032 0.0032
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Onchocerca volvulus 0.0035 0.0006 0.0018
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0078 0.0032 0.0044
Echinococcus multilocularis two pore calcium channel protein 1 0.0076 0.0031 0.0042
Brugia malayi Integrin alpha pat-2 precursor 0.8472 0.514 0.514
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Echinococcus granulosus shaker cognate 0.015 0.0076 0.0103
Schistosoma mansoni biogenic amine receptor 0.0078 0.0032 0.0055
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0004 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0051 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0078 0.0032 0.0044
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0003 0.0039
Brugia malayi nuclear receptor NHR-88 0.0141 0.0071 0.0071
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0081 0.0034 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0299 0.0167 0.0167
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0172 0.0089 0.0089
Echinococcus multilocularis ryanodine receptor 44f 0.0076 0.0031 0.0042
Mycobacterium leprae Probable lipase LipE 0.0109 0.0051 0.0261
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.015 0.0076 0.0103
Brugia malayi ORL1-like opioid receptor 0.0078 0.0032 0.0032
Chlamydia trachomatis DNA ligase 0.0031 0.0004 0.5
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.015 0.0076 0.0076
Onchocerca volvulus 0.006 0.0021 0.0063
Schistosoma mansoni neuropeptide receptor 0.0078 0.0032 0.0055
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0019 0.0026
Onchocerca volvulus 0.0078 0.0032 0.0097
Echinococcus multilocularis neuropeptide Y receptor 0.0078 0.0032 0.0044
Schistosoma mansoni biogenic amine receptor 0.0078 0.0032 0.0055
Echinococcus granulosus neuropeptides capa receptor 0.0078 0.0032 0.0044
Echinococcus granulosus potassium voltage gated channel subfamily D 0.015 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0078 0.0032 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0051 0.0087
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0076 0.0031 0.0053
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.001 0.0013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0023 0.0031
Brugia malayi Pre-SET motif family protein 0.0408 0.0233 0.0233
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0299 0.0167 0.0286
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0051 0.0069
Brugia malayi Importin beta-1 subunit 0.0029 0.0003 0.0003
Echinococcus multilocularis voltage dependent calcium channel 0.0076 0.0031 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0051 0.1161
Echinococcus multilocularis orexin receptor type 2 0.0078 0.0032 0.0044
Schistosoma mansoni amine GPCR 0.0078 0.0032 0.0055
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) RNA binding protein 0.0319 0.0179 0.0179
Brugia malayi putative neuropeptide receptor 0.0078 0.0032 0.0032
Brugia malayi hypothetical protein 0.0158 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.0042
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.3005 0.1814 1
Echinococcus granulosus nAChR subunit 0.0044 0.0011 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0012 0.0016
Brugia malayi hypothetical protein 0.0037 0.0007 0.0007
Schistosoma mansoni polycystin 1-related 0.074 0.0435 0.0746
Brugia malayi Protein kinase domain containing protein 0.0343 0.0194 0.0194
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0019 0.0019
Brugia malayi Kelch motif family protein 0.2531 0.1525 0.1525
Echinococcus multilocularis hyperpolarization activated cyclic 0.0076 0.0031 0.0042
Trypanosoma cruzi adenosine kinase, putative 0.0084 0.0036 0.0813
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0019 0.0101
Loa Loa (eye worm) hypothetical protein 0.0345 0.0195 0.0195
Echinococcus multilocularis voltage gated potassium channel 0.0076 0.0031 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0299 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0372 0.0211 0.0211
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0081 0.0034 0.0046
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0141 0.0071 0.0213
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0158 0.0081 0.011
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0076 0.0031 0.0031
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0734 0.0431 0.074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.0164 1
Loa Loa (eye worm) voltage-gated potassium channel 0.015 0.0076 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.005 0.0068
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0001 0.0001
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0004 0.0004
Onchocerca volvulus 0.0078 0.0032 0.0097
Brugia malayi olfactory channel protein osm-9 0.0076 0.0031 0.0031
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0076 0.0031 0.0693
Echinococcus granulosus g protein coupled receptor 0.0078 0.0032 0.0044
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0031 0.103
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0076 0.0031 0.0042
Echinococcus granulosus two pore calcium channel protein 2 0.0076 0.0031 0.0042
Loa Loa (eye worm) nuclear receptor NHR-67 0.0141 0.0071 0.0071
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0012 0.0255
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus granulosus sodium channel protein 0.0189 0.01 0.0135
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.0007 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0299 0.0167 0.0503
Echinococcus multilocularis voltage gated potassium channel 0.015 0.0076 0.0103
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0299 0.0167 0.0286
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0051 0.1793
Loa Loa (eye worm) TYRA-2 protein 0.0078 0.0032 0.0032
Trypanosoma cruzi adenosine kinase, putative 0.0084 0.0036 0.0813
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0051 0.1793
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Echinococcus granulosus g protein coupled receptor 0.0078 0.0032 0.0044
Echinococcus granulosus TRP transient receptor potential channel 0.0076 0.0031 0.0042
Leishmania major potassium voltage-gated channel, putative 0.0075 0.003 0.0681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Brugia malayi Cation transporter family protein 0.0081 0.0034 0.0034
Brugia malayi RNA binding protein 0.0319 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Onchocerca volvulus Neuropeptide F receptor homolog 0.0078 0.0032 0.0097
Onchocerca volvulus Bile acid receptor homolog 0.0299 0.0167 0.0503
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0019 0.0425
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0032 0.0032
Brugia malayi Hemopexin family protein 0.3499 0.2114 0.2114
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0076 0.0031 0.0053
Echinococcus granulosus potassium voltage gated channel subfamily A 0.1723 0.1033 0.1402
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0051 0.0261
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0081 0.0034 0.0046
Mycobacterium ulcerans hypothetical protein 0.0109 0.0051 0.0276
Giardia lamblia High cysteine protein 0.0336 0.0189 1
Schistosoma mansoni edp1-related 0.0075 0.003 0.0052
Loa Loa (eye worm) LGC-31 protein 0.0081 0.0034 0.0034
Echinococcus granulosus hyperpolarization activated cyclic 0.0076 0.0031 0.0042
Giardia lamblia Tenascin precursor 0.0336 0.0189 1
Echinococcus granulosus potassium voltage gated channel protein 0.015 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.1977 0.1188 0.1188
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0078 0.0032 0.0044
Schistosoma mansoni hypothetical protein 0.0172 0.0089 0.0153
Brugia malayi hypothetical protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0123 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0107 0.005 0.0086
Schistosoma mansoni neuropeptide receptor 0.0078 0.0032 0.0055
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.0053
Schistosoma mansoni alpha-1 adrenergic receptor 0.0078 0.0032 0.0055
Schistosoma mansoni DNA ligase IV 0.0031 0.0004 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0001 0.0001
Echinococcus granulosus short transient receptor potential channel 6 0.0076 0.0031 0.0042
Echinococcus multilocularis potassium voltage gated channel protein 0.1723 0.1033 0.1402
Echinococcus granulosus nuclear receptor nhr 48 0.0141 0.0071 0.0096
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Brugia malayi hypothetical protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0336 0.0189 0.0189
Mycobacterium ulcerans lipase LipD 0.0109 0.0051 0.0276
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0078 0.0032 0.0097
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0004 0.0218
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0076 0.0031 0.1468
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0081 0.0034 0.0034
Brugia malayi hypothetical protein 0.0141 0.0071 0.0071
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.8188 0.4968 1
Brugia malayi sulfakinin receptor protein 0.0078 0.0032 0.0032
Onchocerca volvulus 0.0078 0.0032 0.0097
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.0007 0.001
Echinococcus granulosus hypothetical protein 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0299 0.0167 0.0167
Brugia malayi hypothetical protein 0.0141 0.0071 0.0071
Onchocerca volvulus 0.0081 0.0034 0.0103
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0004 0.006
Loa Loa (eye worm) calcium channel 0.0076 0.0031 0.0031
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0081 0.0034 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0013 0.0018
Echinococcus granulosus voltage gated potassium channel 0.0076 0.0031 0.0042
Echinococcus granulosus cpg binding protein 0.0064 0.0024 0.0032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0012 0.0313
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0078 0.0032 0.0055
Echinococcus multilocularis fibrillin 2 0.0336 0.0189 0.0256
Schistosoma mansoni patched 1 0.0041 0.001 0.0017
Schistosoma mansoni histamine h1 receptor 0.0078 0.0032 0.0055
Brugia malayi PHD-finger family protein 0.0028 0.0002 0.0002
Brugia malayi hypothetical protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0081 0.0034 0.0046
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0081 0.0034 0.0046
Giardia lamblia Neurogenic locus notch-like protein 0.0336 0.0189 1
Leishmania major hypothetical protein, unknown function 0.0076 0.0031 0.0693
Entamoeba histolytica hypothetical protein 0.0107 0.005 0.2903
Brugia malayi nuclear receptor NHR-88 0.0299 0.0167 0.0167
Loa Loa (eye worm) G-protein coupled receptor 0.0078 0.0032 0.0032
Onchocerca volvulus 0.0336 0.0189 0.057
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0141 0.0071 0.0096
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0078 0.0032 0.0055
Brugia malayi Bromodomain containing protein 0.0038 0.0008 0.0008
Brugia malayi Nuclear hormone receptor E75 0.0141 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Echinococcus multilocularis sex peptide receptor 0.0078 0.0032 0.0044
Onchocerca volvulus 0.0037 0.0007 0.0023
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0043 0.2471
Loa Loa (eye worm) ACC-1 protein 0.0081 0.0034 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0051 0.1793
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0031 0.103
Brugia malayi Tachykinin-like peptides receptor 99D 0.0078 0.0032 0.0032
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0051 0.0261
Echinococcus granulosus potassium voltage gated channel subfamily D 0.015 0.0076 0.0103
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Schistosoma mansoni nuclear hormone receptor 0.0141 0.0071 0.0121
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0013 0.0022
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.015 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Echinococcus granulosus geminin 0.0165 0.0085 0.0116
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.2395 0.1442 0.2473
Onchocerca volvulus 0.0078 0.0032 0.0097
Loa Loa (eye worm) hypothetical protein 0.1821 0.1093 0.1093
Echinococcus multilocularis sodium leak channel non selective protein 0.0076 0.0031 0.0042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0299 0.0167 0.0286
Echinococcus multilocularis integrin beta 2 1.2139 0.7372 1
Mycobacterium ulcerans hydrolase 0.3005 0.1814 1
Brugia malayi neuropeptide F receptor 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0051 0.0087
Loa Loa (eye worm) hypothetical protein 0.6651 0.4033 0.4033
Schistosoma mansoni neurotransmitter gated ion channel 0.0037 0.0007 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.1723 0.1033 0.1402
Schistosoma mansoni nAChR subunit 0.0037 0.0007 0.0013
Schistosoma mansoni cpg binding protein 0.0064 0.0024 0.0041
Echinococcus multilocularis nuclear receptor nhr 48 0.0141 0.0071 0.0096
Loa Loa (eye worm) hypothetical protein 0.0096 0.0043 0.0043
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0051 0.0261
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0043 0.0043
Onchocerca volvulus 0.0075 0.003 0.0091
Loa Loa (eye worm) hypothetical protein 0.005 0.0015 0.0015
Echinococcus multilocularis somatostatin receptor 0.0078 0.0032 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0043 0.0059
Echinococcus multilocularis transient receptor potential gamma protein 0.0076 0.0031 0.0042
Brugia malayi nuclear receptor RXR 0.0158 0.0081 0.0081
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0081 0.0034 0.0034
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0004 0.0065
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0019 0.0101
Onchocerca volvulus 0.0078 0.0032 0.0097
Schistosoma mansoni hypothetical protein 0.004 0.0009 0.0015
Loa Loa (eye worm) voltage-gated calcium channel 0.0076 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0299 0.0167 0.0167
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0076 0.0031 0.0031
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.015 0.0076 0.0103
Schistosoma mansoni acetylcholine receptor subunit beta 0.0037 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.8972 0.5445 0.7386
Brugia malayi Melatonin receptor type 1A 0.0078 0.0032 0.0032
Echinococcus granulosus somatostatin receptor 0.0078 0.0032 0.0044
Echinococcus multilocularis conserved hypothetical protein 0.0076 0.0031 0.0042
Schistosoma mansoni integrin alpha-ps 0.1977 0.1188 0.2037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0299 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0078 0.0032 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0021 0.0036
Brugia malayi AKH receptor 0.0078 0.0032 0.0032
Echinococcus granulosus neuropeptide receptor 0.0078 0.0032 0.0044
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0076 0.0031 0.0053
Plasmodium falciparum carbonic anhydrase 0.0345 0.0195 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Schistosoma mansoni voltage-gated potassium channel 0.015 0.0076 0.0131
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0081 0.0034 0.0034
Echinococcus multilocularis cpg binding protein 0.0064 0.0024 0.0032
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0076 0.0031 0.0042
Onchocerca volvulus 0.0081 0.0034 0.0103
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0081 0.0034 0.0034
Onchocerca volvulus 0.0078 0.0032 0.0097
Echinococcus multilocularis integrin alpha ps 0.1821 0.1093 0.1482
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Echinococcus granulosus tar DNA binding protein 0.0319 0.0179 0.0242
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0004 0.0005
Echinococcus granulosus glycine receptor subunit beta 0.0081 0.0034 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0299 0.0167 0.0167
Schistosoma mansoni voltage-gated cation channel 0.0076 0.0031 0.0053
Echinococcus granulosus BTB:POZ domain containing protein 0.0075 0.003 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0019 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0043 0.0059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0299 0.0167 0.0226
Brugia malayi follicle stimulating hormone receptor 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Echinococcus granulosus expressed conserved protein 0.009 0.004 0.0054
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.1648 0.0988 0.134
Giardia lamblia hypothetical protein 0.0336 0.0189 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0544 0.0316 0.0316
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0072 0.0378
Echinococcus granulosus ecdysone induced protein 78C 0.0299 0.0167 0.0226
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.0164 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0299 0.0167 0.0226
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0075 0.003 0.0681
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0004 0.0063
Leishmania major adenosine kinase, putative 0.0084 0.0036 0.0813
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.0175 0.0175
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0141 0.0071 0.0096
Leishmania major hypothetical protein, conserved 0.0075 0.003 0.0681
Onchocerca volvulus 0.0078 0.0032 0.0097
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0299 0.0167 0.0167
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0408 0.0233 0.0233
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0034 0.0034
Mycobacterium ulcerans beta-lactamase 0.0109 0.0051 0.0276
Schistosoma mansoni thyroid hormone receptor 0.0299 0.0167 0.0286
Echinococcus multilocularis neuropeptides capa receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0004 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.003 0.0681
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0068 0.0093
Onchocerca volvulus 0.005 0.0015 0.0046
Echinococcus multilocularis potassium voltage gated channel protein 0.015 0.0076 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0141 0.0071 0.0071
Onchocerca volvulus 0.0078 0.0032 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.005 0.0068
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0081 0.0034 0.0058
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0078 0.0032 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0299 0.0167 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0319 0.0179 0.0306
Onchocerca volvulus Matrilysin homolog 0.2468 0.1486 0.4483
Echinococcus multilocularis carbonic anhydrase 0.0345 0.0195 0.0264
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0037 0.0007 0.0007
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.0053
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0004 0.0006
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0013 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi hypothetical protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.0336 0.0189 0.9706
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0189 0.01 0.2294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Giardia lamblia Neurogenic locus Notch protein precursor 0.0336 0.0189 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0034 0.0034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0299 0.0167 0.0226
Brugia malayi RNA, U transporter 1 0.0083 0.0035 0.0035
Onchocerca volvulus 0.0044 0.0011 0.0034
Echinococcus granulosus potassium voltage gated channel protein 0.015 0.0076 0.0103
Schistosoma mansoni myosin xvIII 0.0078 0.0032 0.0055
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0345 0.0195 0.0195
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0075 0.003 0.5727
Loa Loa (eye worm) carbonic anhydrase 3 0.0734 0.0431 0.0431
Brugia malayi nuclear hormone receptor family member odr-7 0.0141 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.2468 0.1486 0.2549
Brugia malayi Cytochrome P450 family protein 0.0055 0.0018 0.0018
Brugia malayi Bromodomain containing protein 0.0077 0.0032 0.0032
Schistosoma mansoni opsin-like receptor 0.0078 0.0032 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0051 0.0069
Schistosoma mansoni two-pore calcium channel 0.0076 0.0031 0.0053
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Giardia lamblia Tenascin-like 0.0336 0.0189 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0081 0.0034 0.0034
Loa Loa (eye worm) GABA receptor subunit 0.0044 0.0011 0.0011
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0076 0.0031 0.0693
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Onchocerca volvulus Huntingtin homolog 0.0123 0.006 0.018
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Echinococcus granulosus dro:myosuppressin receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0734 0.0431 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0012 0.006
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0076 0.0031 0.0042
Echinococcus multilocularis integrin alpha 3 0.6494 0.3937 0.534
Schistosoma mansoni biogenic amine receptor 0.0078 0.0032 0.0055
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0021 0.0028
Schistosoma mansoni voltage-gated potassium channel 0.0076 0.0031 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0032 0.0044
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.0042
Schistosoma mansoni topbp1 0.0031 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0319 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.003 0.003
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0076 0.0031 0.0053
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0037 0.0007 0.0007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0023 0.0031
Giardia lamblia Tenascin-X 0.0336 0.0189 1
Echinococcus granulosus tm gpcr rhodopsin 0.1953 0.1173 0.1592
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0076 0.0031 0.0031
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.1723 0.1033 0.1033
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0001 0.0001
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.015 0.0076 0.0103
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0076 0.0031 0.0693
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0141 0.0071 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.0076 0.0031 0.0042
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0051 0.0261
Onchocerca volvulus 0.0078 0.0032 0.0097
Brugia malayi ion channel NompC 0.0076 0.0031 0.0031
Echinococcus granulosus integrin alpha 3 0.6494 0.3937 0.534
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0734 0.0431 0.0431
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0012 0.0016
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0009 0.003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0158 0.0081 0.011
Echinococcus granulosus voltage gated potassium channel 0.015 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0345 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.2468 0.1486 0.1486
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0734 0.0431 0.0431
Onchocerca volvulus 0.0059 0.0021 0.0063
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0299 0.0167 0.0167
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0734 0.0431 0.074
Loa Loa (eye worm) hypothetical protein 0.0336 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0004 0.0063
Echinococcus multilocularis protein patched 0.0041 0.001 0.0013
Onchocerca volvulus 0.0044 0.0011 0.0034
Echinococcus multilocularis allatostatin A receptor 0.0078 0.0032 0.0044
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.0042
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0004 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0299 0.0167 0.0167
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0158 0.0081 0.0081
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Brugia malayi TAR-binding protein 0.0319 0.0179 0.0179
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0081 0.0034 0.0034
Echinococcus granulosus calcium activated potassium channel 0.0076 0.0031 0.0042
Schistosoma mansoni neurotransmitter gated ion channel 0.0037 0.0007 0.0013
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0078 0.0032 0.0055
Echinococcus multilocularis ecdysone induced protein 78C 0.0299 0.0167 0.0226
Trypanosoma brucei potassium voltage-gated channel, putative 0.0075 0.003 0.0681
Echinococcus multilocularis hyperpolarization activated cyclic 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0078 0.0032 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Echinococcus granulosus potassium voltage gated channel subfamily C 0.015 0.0076 0.0103
Echinococcus granulosus carbonic anhydrase 0.0345 0.0195 0.0264
Echinococcus granulosus importin subunit beta 1 0.0029 0.0003 0.0003
Echinococcus multilocularis nibrin 0.0031 0.0004 0.0005
Loa Loa (eye worm) inositol-1 0.0045 0.0012 0.0012
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0078 0.0032 0.0055
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0076 0.0031 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0299 0.0167 0.0226
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) matrixin family protein 0.5473 0.3315 0.3315
Schistosoma mansoni hypothetical protein 0.3499 0.2114 0.3625
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0004 0.0063
Echinococcus granulosus alpha 1A adrenergic receptor 0.0078 0.0032 0.0044
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0017 0.0017
Onchocerca volvulus 0.0078 0.0032 0.0097
Echinococcus granulosus neuropeptide receptor 0.0988 0.0586 0.0795
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0015 0.0026
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0004 0.0063
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0076 0.0031 0.0031
Brugia malayi MH2 domain containing protein 0.0116 0.0056 0.0056
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0076 0.0031 0.0031
Echinococcus multilocularis glycine receptor subunit beta 0.0081 0.0034 0.0046
Echinococcus granulosus potassium voltage gated channel protein 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Cytochrome P450 family protein 0.0027 0.0001 0.0001
Echinococcus granulosus microtubule associated protein 2 0.211 0.1269 0.1721
Schistosoma mansoni amine GPCR 0.0078 0.0032 0.0055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0006 0.0009
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0081 0.0034 0.0046
Trypanosoma brucei adenosine kinase, putative 0.0084 0.0036 0.0813
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0013 0.0018
Schistosoma mansoni RAR-like nuclear receptor 0.0299 0.0167 0.0286
Echinococcus granulosus nibrin 0.0031 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Trichomonas vaginalis hypothetical protein 0.0336 0.0189 0.7034
Echinococcus granulosus rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0021 0.0021
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0734 0.0431 0.0431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0004 0.0005
Brugia malayi beta-lactamase 0.0109 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Trypanosoma brucei potassium voltage-gated channel, putative 0.0075 0.003 0.0681
Echinococcus granulosus neuropeptide Y receptor 0.0078 0.0032 0.0044
Onchocerca volvulus 0.0078 0.0032 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0013 0.0013
Echinococcus multilocularis nAChR subunit 0.0081 0.0034 0.0046
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.8972 0.5445 0.7386
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0075 0.003 0.1441
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0051 0.0261
Loa Loa (eye worm) integrin alpha pat-2 1.1224 0.6816 0.6816
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi hypothetical protein 0.2531 0.1525 0.1525
Brugia malayi beta-lactamase family protein 0.0109 0.0051 0.0051
Schistosoma mansoni amine GPCR 0.0078 0.0032 0.0055
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0076 0.0031 0.0031
Schistosoma mansoni zinc finger protein 0.0141 0.0071 0.0121
Echinococcus granulosus carbonic anhydrase 0.0345 0.0195 0.0264
Schistosoma mansoni hypothetical protein 0.1821 0.1093 0.1874
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0032 0.0055
Echinococcus granulosus integrin alpha ps 0.1821 0.1093 0.1482
Schistosoma mansoni hypothetical protein 0.0372 0.0211 0.0362
Echinococcus granulosus ankyrin repeat protein 0.0161 0.0083 0.0113
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0076 0.0031 0.0042
Schistosoma mansoni integrin alpha-ps 0.3798 0.2296 0.3937
Loa Loa (eye worm) hypothetical protein 0.1723 0.1033 0.1033
Brugia malayi hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0004 0.0004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0078 0.0032 0.0044
Schistosoma mansoni nuclear receptor 0.0141 0.0071 0.0121
Brugia malayi nuclear hormone receptor family member nhr-6 0.0141 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0004 0.0005
Brugia malayi DKFZp564C0469 protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0109 0.0051 0.0051
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0081 0.0034 0.0046
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0076 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Echinococcus granulosus voltage dependent calcium channel 0.0076 0.0031 0.0042
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0081 0.0034 0.0046
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0004 0.0063
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0076 0.0031 0.0031
Brugia malayi hypothetical protein 0.0158 0.0081 0.0081
Echinococcus multilocularis calcium activated potassium channel 0.0076 0.0031 0.0042
Brugia malayi isocitrate dehydrogenase 0.0031 0.0004 0.0004
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0081 0.0034 0.0046
Echinococcus granulosus glycine receptor subunit alpha 1 0.0081 0.0034 0.0046
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0009 0.0029
Brugia malayi cation channel family protein 0.0076 0.0031 0.0031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0141 0.0071 0.0096
Loa Loa (eye worm) DR-78 0.0141 0.0071 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0172 0.0089 0.0121
Onchocerca volvulus 0.0075 0.003 0.0091
Schistosoma mansoni adenoreceptor 0.0078 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni 60S ribosomal protein L21 0.0076 0.0031 0.0053
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0044 0.0011 0.0011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0544 0.0316 0.0316
Echinococcus multilocularis carbonic anhydrase II 0.0734 0.0431 0.0585
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0076 0.0031 0.0054
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0051 0.0261
Schistosoma mansoni opsin-like receptor 0.0078 0.0032 0.0055
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0019 0.0033
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0076 0.0031 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.001
Brugia malayi Inositol-1 0.0045 0.0012 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0068 0.0093
Schistosoma mansoni voltage-gated potassium channel 0.1723 0.1033 0.1772
Echinococcus granulosus voltage dependent calcium channel 0.0076 0.0031 0.0042
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0078 0.0032 0.0032
Brugia malayi G protein-coupled receptor F59B2.13 0.0078 0.0032 0.0032
Toxoplasma gondii transporter, cation channel family protein 0.0076 0.0031 0.1468
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.002 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Echinococcus granulosus integrin beta 2 1.2139 0.7372 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0037 0.0007 0.001
Schistosoma mansoni neuropeptide receptor 0.0078 0.0032 0.0055
Echinococcus multilocularis adenosine kinase 0.0084 0.0036 0.0049
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0078 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0004
Loa Loa (eye worm) voltage-gated potassium channel 0.0076 0.0031 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0051 0.1161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0078 0.0032 0.0044
Echinococcus multilocularis transient receptor potential cation channel 0.0076 0.0031 0.0042
Plasmodium vivax kelch protein K13, putative 0.0075 0.003 0.5727
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Brugia malayi Matrixin family protein 0.5967 0.3616 0.3616
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0081 0.0034 0.0046
Loa Loa (eye worm) hypothetical protein 0.0084 0.0036 0.0036
Echinococcus granulosus transient receptor potential cation channel 0.0076 0.0031 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0078 0.0032 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.0164 0.6077
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni nAChR subunit 0.0081 0.0034 0.0058
Onchocerca volvulus 0.0109 0.0051 0.0153
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0076 0.0031 0.0693
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0004 0.0005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0012 0.0017
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0021 0.096
Loa Loa (eye worm) voltage-dependent calcium channel 0.0076 0.0031 0.0031
Echinococcus multilocularis carbonic anhydrase 0.0345 0.0195 0.0264
Schistosoma mansoni transient receptor potential channel 4 0.0076 0.0031 0.0053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Brugia malayi Dopamine receptor protein 1 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.015 0.0076 0.0076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0299 0.0167 0.0226
Toxoplasma gondii transporter, cation channel family protein 0.0076 0.0031 0.1468
Echinococcus granulosus Nuclear hormone receptor HR96 0.0141 0.0071 0.0096
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0076 0.0031 0.0053
Echinococcus granulosus ryanodine receptor 44f 0.0076 0.0031 0.0042
Schistosoma mansoni carbonic anhydrase 0.0345 0.0195 0.0334
Onchocerca volvulus 0.0031 0.0004 0.0011
Brugia malayi Matrixin family protein 0.2468 0.1486 0.1486
Echinococcus multilocularis neuropeptide receptor 0.0988 0.0586 0.0795
Schistosoma mansoni single-minded 0.0047 0.0013 0.0023
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0299 0.0167 0.0226
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.0164 0.864
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0032 0.0044
Echinococcus multilocularis fmrfamide receptor 0.0078 0.0032 0.0044
Schistosoma mansoni voltage-gated potassium channel 0.1723 0.1033 0.1772
Schistosoma mansoni voltage-gated ion channel 0.0076 0.0031 0.0053
Onchocerca volvulus Matrilysin homolog 0.5473 0.3315 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0031 0.0031
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0078 0.0032 0.0055
Trypanosoma brucei carbonic anhydrase-like protein 0.0734 0.0431 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0313 0.0175 0.03
Echinococcus multilocularis potassium voltage gated channel protein 0.0076 0.0031 0.0042
Brugia malayi Cation transporter family protein 0.0081 0.0034 0.0034
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0037 0.0007 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0299 0.0167 0.0167
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0299 0.0167 0.0226
Brugia malayi Matrixin family protein 0.2468 0.1486 0.1486
Echinococcus granulosus fibrillin 2 0.0336 0.0189 0.0256
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.0073 0.0073
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0076 0.0031 0.0042
Loa Loa (eye worm) integrin beta-2 1.6457 1 1
Leishmania major hypothetical protein, conserved 0.0075 0.003 0.0681
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.0062 0.0107
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0004 0.0065
Loa Loa (eye worm) hypothetical protein 0.0078 0.0032 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0078 0.0032 0.0055
Mycobacterium tuberculosis Conserved protein 0.0109 0.0051 0.0261
Schistosoma mansoni adenosine kinase 0.0084 0.0036 0.0062
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0012 0.0515
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0078 0.0032 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0141 0.0071 0.0096
Brugia malayi Serotonin receptor 0.0078 0.0032 0.0032
Schistosoma mansoni carbonic anhydrase-related 0.0345 0.0195 0.0334
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Brugia malayi excitatory GABA receptor EXP-1A 0.0081 0.0034 0.0034
Brugia malayi G-protein coupled receptor 0.0078 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0299 0.0167 0.0167
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.003 0.0681
Echinococcus multilocularis short transient receptor potential channel 6 0.0076 0.0031 0.0042
Schistosoma mansoni neurotransmitter gated ion channel 0.0044 0.0011 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.015 0.0076 0.0131
Echinococcus granulosus potassium large conductance calcium activated 0.0076 0.0031 0.0042
Brugia malayi EGF-like domain containing protein 0.0336 0.0189 0.0189
Echinococcus granulosus 7TM GPCR rhodopsin 0.0078 0.0032 0.0044
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0076 0.0031 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.005 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0013 0.0022
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0081 0.0034 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.0299 0.0167 0.0226
Loa Loa (eye worm) hypothetical protein 0.0172 0.0089 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0013 0.0022
Schistosoma mansoni nuclear hormone receptor 0.0299 0.0167 0.0286
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0081 0.0034 0.0034
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0012 0.0313
Loa Loa (eye worm) neuropeptide F receptor 0.0078 0.0032 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0076 0.0031 0.0042
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0081 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0172 0.0089 0.0153
Loa Loa (eye worm) acetylcholine receptor protein 0.0037 0.0007 0.0007
Echinococcus multilocularis neuropeptide s receptor 0.0078 0.0032 0.0044
Onchocerca volvulus 0.3499 0.2114 0.6376
Schistosoma mansoni neuropeptide f receptor 76f 0.0078 0.0032 0.0055
Schistosoma mansoni nAChR subunit 0.0081 0.0034 0.0058
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0012 0.0255
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0075 0.003 0.003

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Agonist activity at human recombinant KOR expressed in CHO cells at 1 uM by calcium mobilization assay ChEMBL. 26944625
EC50 (binding) = 6.43 Agonist activity at human recombinant DOR expressed in CHO cells by calcium mobilization assay ChEMBL. 26944625
EC50 (binding) = 8.4 Agonist activity at human recombinant MOR expressed in CHO cells by calcium mobilization assay ChEMBL. 26944625
ED50 (functional) = 0.00000095 M kg-1 Analgesic activity in mice by using hot plate method ChEMBL. 6312044
ED50 (functional) = 11.39 pM mouse-1 In vivo analgesic activity in the mouse tail-flick assay following i.c.v. administration. ChEMBL. 4009598
ED50 (functional) = 11.4 pM mouse-1 The compound was evaluated for the analgesic activity by tail-flick test after icv administration of compound in mouse; value ranges from 6.6-27.1 ChEMBL. 2887656
ED50 (functional) = 2.75 uM kg-1 The compound was evaluated for the analgesic activity by tail-flick test after subcutaneous administration of compound in mouse; value ranges from 1.73-6.4 ChEMBL. 2887656
ED50 (functional) = 2.75 uM kg-1 In vivo analgesic activity in the mouse tail-flick assay following s.c. administration. ChEMBL. 4009598
ED50 (functional) = 2.75 uM mouse-1 In Vivo opioid activity was evaluated by determining analgesia in the mouse by the tail-flick test when administered through intra cerebro ventricular route ChEMBL. 2872334
IC50 (functional) = 0.000000000052 M Inhibition of twitches in guinea pig ileum ChEMBL. 6312044
IC50 (binding) = 0.538 nM Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenate ChEMBL. 16814543
IC50 (functional) = 1.41 nM In vitro opioid inhibitory activity against in guinea pig ileum ChEMBL. 2872334
IC50 (functional) = 1.41 nM In vitro inhibition of contractions in the electrically stimulated guinea pig ileum. ChEMBL. 4009598
IC50 (binding) = 5.7 nM Evaluated for the inhibition of [3H]-DAGO binding to mu-receptor of guinea pig brain ChEMBL. 2887656
IC50 (binding) = 36.7 nM Binding affinity at mu opioid receptor (unknown origin) ChEMBL. 26656913
IC50 (binding) = 210 nM Evaluated for the inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of guinea pig brain ChEMBL. 2887656
IC50 (binding) = 1247 nM Binding affinity at delta opioid receptor (unknown origin) ChEMBL. 26656913
IC50 (binding) > 10000 nM Evaluated for the inhibition of [3H]-EKC binding to Opioid receptor kappa 1 of guinea pig brain ChEMBL. 2887656
IC50 (binding) > 10000 nM Displacement of [3H]NOC from human ORL1 receptor expressed in HEK293 cells ChEMBL. 16814543
Intrinsic activity (binding) = 1.03 Intrinsic activity at human recombinant DOR expressed in CHO cells by calcium mobilization assay relative to DPDPE ChEMBL. 26944625
Ki (binding) = 0.28 nM Binding affinity for rat brain P2 synaptosome Opioid receptor mu 1 ChEMBL. 11806723
Ki (binding) = 82.5 nM Binding affinity of the compound at Opioid receptor delta 1 using rat brain receptor (P2 synaptosome) assay ChEMBL. 11806723
Log EC50 (functional) = 9.15 Negative logarithm of the molar concentration of an agonist to produce 50% of the maximum effect in guinea pig ileum (mu receptor) determined ChEMBL. 11806723
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Ratio (functional) = 37 Selectivity ratio of IC50 of mu receptor to IC50 of delta receptor ChEMBL. 2887656
Relative potency (binding) = 0.7 Relative potency of the compound with respect to morphine was evaluated for mu-receptor of guinea pig brain ChEMBL. 2887656
Relative potency (binding) = 0.88 Relative potency of the compound with respect to morphine was evaluated for Opioid receptor delta 1 of guinea pig brain ChEMBL. 2887656
Relative potency (functional) = 3.9 Relative potency was determined for the compound with respect to morphine activity (1) after subcutaneous administration ChEMBL. 2887656
Relative potency (functional) = 3.98 In vivo analgesic potency in mice compared to morphine after s.c. administration. ChEMBL. 4009598
Relative potency (functional) = 4 In vivo opioid activity was evaluated by determining analgesia in the mouse by the tail-flick test .Relative potency of the compound with respect to morphine when administered through subcutaneous route ChEMBL. 2872334
Relative potency (binding) = 11.4 Compound was tested in vitro for the inhibitory activity against opioid activity in guinea pig ileum ChEMBL. 2872334
Relative potency (functional) = 41.5 Relative potency compared to Morphine in electrically stimulated guinea pig ileum. ChEMBL. 4009598
Relative potency (binding) = 46 Compound was tested in vitro for the inhibitory activity against opioid activity in guinea pig ileum ,relative to Morphine ChEMBL. 2872334
Relative potency (functional) = 266 In vivo opioid activity was evaluated by determining analgesia in the mouse by the tail-flick test,Relative potency of the compound with respect to morphine intra cerebro ventricular route ChEMBL. 2872334
Relative potency (functional) = 266.02 In vivo analgesic potency in mice compared to morphine after i.c.v. administration. ChEMBL. 4009598
Relative potency (functional) = 271 Relative potency was determined for the compound with respect to morphine activity (1) after icv administration ChEMBL. 2887656
Relative potency (functional) = 1440 Inhibition of electrically evoked twitches in guinea pig ileum relative to morphine. ChEMBL. 6312044
T1/2 (ADMET) = 35 min Half-life of the compound ChEMBL. 4009598
T1/2 (ADMET) = 40 min Half-life of the compound was determined ChEMBL. 4009598

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

8 literature references were collected for this gene.

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