Detailed information for compound 502393

Basic information

Technical information
  • TDR Targets ID: 502393
  • Name: 2-(cyclohexanecarbonylamino)-N-[[4-[(naphthal en-2-ylmethylamino)methyl]phenyl]methyl]-1,3- benzothiazole-6-carboxamide
  • MW: 562.724 | Formula: C34H34N4O2S
  • H donors: 3 H acceptors: 3 LogP: 6.85 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C1CCCCC1)Nc1nc2c(s1)cc(cc2)C(=O)NCc1ccc(cc1)CNCc1ccc2c(c1)cccc2
  • InChi: 1S/C34H34N4O2S/c39-32(29-16-17-30-31(19-29)41-34(37-30)38-33(40)27-7-2-1-3-8-27)36-22-24-12-10-23(11-13-24)20-35-21-25-14-15-26-6-4-5-9-28(26)18-25/h4-6,9-19,27,35H,1-3,7-8,20-22H2,(H,36,39)(H,37,38,40)
  • InChiKey: VVKAQCHOXVGFCE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(cyclohexanecarbonylamino)-N-[[4-[(2-naphthylmethylamino)methyl]phenyl]methyl]-1,3-benzothiazole-6-carboxamide
  • 2-[[cyclohexyl(oxo)methyl]amino]-N-[[4-[(2-naphthalenylmethylamino)methyl]phenyl]methyl]-1,3-benzothiazole-6-carboxamide
  • 2-(cyclohexylcarbonylamino)-N-[[4-[(naphthalen-2-ylmethylamino)methyl]phenyl]methyl]-1,3-benzothiazole-6-carboxamide
  • 2-(cyclohexanecarbonylamino)-N-[4-[(2-naphthylmethylamino)methyl]benzyl]-1,3-benzothiazole-6-carboxamide
  • 2-[(cyclohexyl-oxomethyl)amino]-N-[[4-[(2-naphthylmethylamino)methyl]phenyl]methyl]-1,3-benzothiazole-6-carboxamide
  • AIDS-227194
  • AIDS227194
  • 6-Benzothiazolecarboxamide, 2-[(cyclohexylcarbonyl)amino]-N-[[4-[[(2-naphthalenylmethyl)amino]methyl]phenyl]methyl]-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma cruzi N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania infantum N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma cruzi N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Babesia bovis myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain containing protein Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium knowlesi glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania braziliensis N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Brugia malayi N-myristoyltransferase 2 Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Theileria parva N-myristoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium berghei glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Giardia lamblia CDC72 Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania donovani N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma brucei gambiense N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Candida albicans myristoyl-CoA:protein N-myristoyltransferase that is capable of functional substitution for S. cerevisiae NMT1 (YLR195C) Get druggable targets OG5_127597 All targets in OG5_127597
Cryptosporidium hominis N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Schistosoma japonicum ko:K00671 glycylpeptide N-tetradecanoyltransferase [EC2.3.1.97], putative Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania major N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Trypanosoma congolense N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Loa Loa (eye worm) N-myristoyltransferase 2 Get druggable targets OG5_127597 All targets in OG5_127597
Neospora caninum hypothetical protein Get druggable targets OG5_127597 All targets in OG5_127597
Cryptosporidium parvum N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Trichomonas vaginalis N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Schistosoma mansoni N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium yoelii N-myristoyltransferase Get druggable targets OG5_127597 All targets in OG5_127597
Leishmania mexicana N-myristoyl transferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative Get druggable targets OG5_127597 All targets in OG5_127597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0139 0.0181
Onchocerca volvulus 0.0158 0.2104 0.3182
Plasmodium vivax delta tubulin, putative 0.0134 0.1731 0.2257
Loa Loa (eye worm) acetyltransferase 0.0147 0.1936 0.2525
Trypanosoma brucei beta tubulin 0.0527 0.7668 1
Brugia malayi mbt repeat family protein 0.0047 0.0422 0.055
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.052 0.0495
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1491 0.1944
Echinococcus granulosus tubulin alpha chain 0.0388 0.5576 0.5564
Onchocerca volvulus 0.0047 0.0422 0.0458
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.052 0.0678
Echinococcus multilocularis transcription factor Dp 1 0.0075 0.0841 0.0817
Schistosoma mansoni tubulin subunit beta 0.0527 0.7668 0.7668
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0129 0.1664 0.1642
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0139 0.0112
Loa Loa (eye worm) tubulin alpha 2 0.0096 0.1162 0.1516
Schistosoma mansoni tubulin subunit beta 0.0527 0.7668 0.7668
Trichomonas vaginalis tubulin epsilon chain, putative 0.0388 0.5576 0.7262
Mycobacterium tuberculosis Cell division protein FtsZ 0.0134 0.1731 0.5
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0459 0.0565
Schistosoma mansoni hypothetical protein 0.0059 0.0596 0.0596
Trypanosoma brucei epsilon tubulin 0.0292 0.4124 0.5379
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0459 0.0459
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.031 0.0371
Loa Loa (eye worm) MBCTL1 0.0054 0.052 0.0678
Echinococcus granulosus tubulin alpha chain 0.0388 0.5576 0.5564
Schistosoma mansoni alpha tubulin 0.0388 0.5576 0.5576
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0293 0.0249
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0129 0.1664 0.217
Echinococcus multilocularis tubulin alpha chain 0.0388 0.5576 0.5564
Echinococcus multilocularis beta tubulin 0.0527 0.7668 0.7662
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.1731 0.223
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0134 0.1731 0.223
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0216 0.2974 0.2955
Trypanosoma brucei tubulin gamma chain 0.0318 0.4521 0.5896
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.3111 0.4057
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0134 0.1731 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0139 0.0181
Trypanosoma brucei protein kinase, putative 0.005 0.0459 0.0598
Brugia malayi N-myristoyltransferase 2 0.0216 0.2974 0.3879
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Schistosoma mansoni tubulin subunit beta 0.0527 0.7668 0.7668
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0035
Echinococcus granulosus chromobox protein 1 0.0069 0.0749 0.0724
Trichomonas vaginalis tubulin beta chain, putative 0.0158 0.2104 0.2718
Echinococcus multilocularis tubulin delta chain 0.0134 0.1731 0.1709
Toxoplasma gondii alpha tubulin TUBA1 0.0388 0.5576 0.7272
Entamoeba histolytica hypothetical protein 0.0023 0.0059 0.0042
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0055 0.0072
Echinococcus multilocularis Tubulin beta 2C chain 0.0527 0.7668 0.7662
Brugia malayi nuclear hormone receptor 0.0028 0.0139 0.0181
Brugia malayi Tubulin alpha-2 chain 0.0388 0.5576 0.7272
Loa Loa (eye worm) N-myristoyltransferase 2 0.0216 0.2974 0.3879
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1936 0.2525
Loa Loa (eye worm) tubulin beta-4 chain 0.0527 0.7668 1
Echinococcus multilocularis tubulin subunit beta 0.0527 0.7668 0.7662
Trichomonas vaginalis tubulin beta chain, putative 0.0527 0.7668 1
Brugia malayi Tubulin alpha chain 0.0134 0.1731 0.2257
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0596 0.0778
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.154 0.2008
Brugia malayi chromobox protein homolog 3 0.0039 0.0293 0.0382
Echinococcus granulosus tubulin alpha 1C chain 0.0388 0.5576 0.5564
Echinococcus multilocularis importin subunit beta 1 0.0028 0.014 0.0114
Brugia malayi steroid hormone receptor 0.0028 0.0139 0.0181
Echinococcus granulosus Tubulin beta 2C chain 0.0527 0.7668 0.7662
Trypanosoma brucei beta tubulin 0.0527 0.7668 1
Trichomonas vaginalis tubulin, putative 0.0158 0.2104 0.2718
Echinococcus multilocularis tubulin alpha chain 0.0388 0.5576 0.5564
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0139 0.0181
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.014 0.0183
Toxoplasma gondii beta-1 tubulin, putative 0.0527 0.7668 1
Toxoplasma gondii beta tubulin 0.0527 0.7668 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0365 0.0442
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus multilocularis muscleblind protein 0.03 0.425 0.4234
Echinococcus granulosus alpha tubulin 0.0388 0.5576 0.5564
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0783 0.0758
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.5576 0.5564
Leishmania major beta tubulin 0.0527 0.7668 1
Brugia malayi MH2 domain containing protein 0.0118 0.1491 0.1944
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0296 0.4181 0.5453
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0337 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0139 0.0181
Echinococcus granulosus tubulin epsilon chain 0.0318 0.4515 0.45
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0459 0.0598
Leishmania major beta tubulin 0.0527 0.7668 1
Giardia lamblia Beta tubulin 0.0527 0.7668 1
Loa Loa (eye worm) runx1 0.0055 0.0539 0.0703
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0055 0.0072
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0459 0.0565
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.03 0.425 0.5542
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.2612 0.2592
Schistosoma mansoni ran 0.0021 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0293 0.0348
Plasmodium falciparum tubulin epsilon chain, putative 0.0318 0.4515 0.5888
Plasmodium falciparum tubulin gamma chain 0.0318 0.4521 0.5896
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0422 0.0396
Brugia malayi Cytochrome P450 family protein 0.0053 0.0517 0.0675
Leishmania major N-myristoyl transferase, putative 0.0216 0.2974 0.3857
Schistosoma mansoni importin beta-1 0.0028 0.014 0.014
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.052 0.0495
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0139 0.0112
Echinococcus granulosus tubulin beta 1 chain 0.0527 0.7668 0.7662
Echinococcus granulosus muscleblind protein 0.03 0.425 0.4234
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0252 0.0329
Trypanosoma brucei N-myristoyl transferase, putative 0.0216 0.2974 0.3879
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0129 0.1664 0.2143
Brugia malayi Tubulin beta chain 0.0134 0.1731 0.2257
Giardia lamblia Beta tubulin 0.0527 0.7668 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0388 0.5576 0.7262
Brugia malayi jmjC domain containing protein 0.0192 0.2612 0.3406
Schistosoma mansoni tubulin subunit delta 0.0134 0.1731 0.1731
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0365 0.0476
Entamoeba histolytica tubulin alpha-1 chain 0.0388 0.5576 0.7262
Loa Loa (eye worm) alpha-tubulin 0.0388 0.5576 0.7272
Leishmania major zeta tubulin, putative 0.0405 0.5827 0.7591
Echinococcus granulosus tubulin alpha chain 0.0388 0.5576 0.5564
Loa Loa (eye worm) tubulin alpha-2 chain 0.0388 0.5576 0.7272
Schistosoma mansoni jumonji domain containing protein 0.0153 0.2016 0.2016
Loa Loa (eye worm) hypothetical protein 0.0437 0.6315 0.8235
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0292 0.4124 0.5379
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus multilocularis muscleblind protein 1 0.03 0.425 0.4234
Loa Loa (eye worm) hypothetical protein 0.0254 0.3556 0.4637
Mycobacterium ulcerans cell division protein FtsZ 0.0134 0.1731 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0129 0.1664 0.2143
Trypanosoma brucei N-myristoyltransferase 0.0216 0.2974 0.3879
Trypanosoma brucei zeta tubulin 0.0405 0.5827 0.7599
Brugia malayi Cytochrome P450 family protein 0.0023 0.0055 0.0072
Plasmodium falciparum importin beta, putative 0.0028 0.014 0.0183
Brugia malayi Cell division protein ftsZ 0.0134 0.1731 0.2257
Loa Loa (eye worm) alpha-tubulin 0.0388 0.5576 0.7272
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0139 0.0139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0139 0.0112
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.052 0.0495
Schistosoma mansoni N-myristoyltransferase 0.0216 0.2974 0.2974
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0302 0.0302
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0943 0.0919
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Echinococcus multilocularis tubulin alpha 1C chain 0.0388 0.5576 0.5564
Trypanosoma brucei alpha tubulin 0.0388 0.5576 0.7272
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0252 0.0226
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.2612 0.2592
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Giardia lamblia Alpha-tubulin 0.0388 0.5576 0.7262
Leishmania major importin beta-1 subunit, putative 0.0023 0.0059 0.0042
Echinococcus multilocularis tubulin alpha 0.0292 0.4124 0.4109
Giardia lamblia Beta tubulin 0.0527 0.7668 1
Loa Loa (eye worm) BEN-1 protein 0.0527 0.7668 1
Loa Loa (eye worm) tubulin beta chain 0.0527 0.7668 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0293 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0139 0.0181
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.023 0.3183 0.413
Loa Loa (eye worm) tubulin beta-2A chain 0.0527 0.7668 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0216 0.0248
Plasmodium falciparum alpha tubulin 2 0.0388 0.5576 0.7272
Schistosoma mansoni alpha tubulin 0.0388 0.5576 0.5576
Trichomonas vaginalis tubulin alpha chain, putative 0.0292 0.4124 0.5362
Echinococcus granulosus Tubulin beta 2C chain 0.0527 0.7668 0.7662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0139 0.0181
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0596 0.0571
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0422 0.0422
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0749 0.0945
Trichomonas vaginalis tubulin epsilon chain, putative 0.0527 0.7668 1
Schistosoma mansoni tubulin subunit beta 0.0527 0.7668 0.7668
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1936 0.1914
Trypanosoma cruzi zeta tubulin, putative 0.0405 0.5827 0.7591
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0139 0.0181
Trypanosoma brucei beta tubulin 0.0292 0.4124 0.5379
Loa Loa (eye worm) tubulin beta-1 chain 0.0527 0.7668 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0139 0.0112
Echinococcus granulosus Tubulin beta 2C chain 0.0527 0.7668 0.7662
Plasmodium vivax tubulin beta chain, putative 0.0527 0.7668 1
Leishmania major delta tubulin, putative 0.0296 0.4181 0.5437
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0459 0.0565
Trichomonas vaginalis tubulin, putative 0.0158 0.2104 0.2718
Trichomonas vaginalis tubulin gamma chain, putative 0.0318 0.4521 0.5882
Brugia malayi jmjC domain containing protein 0.0071 0.0783 0.1021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0139 0.0139
Entamoeba histolytica tubulin family protein 0.0527 0.7668 1
Brugia malayi Tubulin alpha chain 0.0388 0.5576 0.7272
Brugia malayi tubulin alpha-2 chain 0.0388 0.5576 0.7272
Loa Loa (eye worm) hypothetical protein 0.0059 0.0596 0.0778
Loa Loa (eye worm) hypothetical protein 0.0101 0.1229 0.1603
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0459 0.0565
Brugia malayi ecdysteroid receptor 0.0028 0.0139 0.0181
Brugia malayi MAP kinase sur-1 0.005 0.0459 0.0598
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0459 0.0565
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0055 0.0072
Echinococcus granulosus Tubulin beta 2C chain 0.0527 0.7668 0.7662
Leishmania major beta tubulin 0.0527 0.7668 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.1664 0.2143
Echinococcus multilocularis tubulin alpha 3 chain 0.0388 0.5576 0.5564
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.031 0.0405
Leishmania major beta tubulin 0.0527 0.7668 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.2104 0.2718
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.2104 0.2718
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus granulosus transcription factor Dp 1 0.0075 0.0841 0.0817
Schistosoma mansoni tubulin subunit alpha 0.0388 0.5576 0.5576
Loa Loa (eye worm) hypothetical protein 0.0437 0.6315 0.8235
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0218
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0139 0.0112
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0139 0.0112
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0459 0.0433
Brugia malayi Cytochrome P450 family protein 0.0023 0.0055 0.0072
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0422 0.0396
Schistosoma mansoni tubulin subunit beta 0.0134 0.1731 0.1731
Treponema pallidum cell division protein FtsZ 0.0134 0.1731 0.5
Brugia malayi Tubulin beta-1 chain 0.0527 0.7668 1
Schistosoma mansoni tubulin subunit beta 0.0527 0.7668 0.7668
Echinococcus granulosus tubulin alpha 0.0292 0.4124 0.4109
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0422 0.0458
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0216 0.2974 0.2955
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0139 0.0112
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0129 0.1664 0.217
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.052 0.052
Brugia malayi follicle stimulating hormone receptor 0.0225 0.3111 0.4057
Loa Loa (eye worm) hypothetical protein 0.0388 0.5576 0.7272
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.5576 0.7262
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.031 0.0371
Giardia lamblia Epsilon tubulin 0.016 0.2122 0.2742
Plasmodium vivax tubulin epsilon chain, putative 0.0318 0.4515 0.5888
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0783 0.1021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0252 0.0226
Plasmodium falciparum alpha tubulin 1 0.0388 0.5576 0.7272
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0254 0.3556 0.4618
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0252 0.0329
Plasmodium falciparum tubulin delta chain, putative 0.0134 0.1731 0.2257
Trypanosoma brucei alpha tubulin 0.0388 0.5576 0.7272
Plasmodium vivax importin-beta 2, putative 0.0028 0.014 0.0183
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0459 0.0598
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0139 0.0181
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.014 0.0183
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1491 0.1944
Echinococcus granulosus snurportin 1 0.0304 0.43 0.4285
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0035
Leishmania major epsilon tubulin, putative 0.0318 0.4515 0.5874
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0459 0.0565
Schistosoma mansoni chromobox protein 0.0069 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0139 0.0181
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.5576 0.5564
Brugia malayi mbt repeat family protein 0.0047 0.0422 0.055
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.016 0.2122 0.2767
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1874 0.1852
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0596 0.0778
Trichomonas vaginalis N-myristoyl transferase, putative 0.0216 0.2974 0.3857
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0139 0.0181
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0783 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0139 0.0181
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0139 0.0139
Schistosoma mansoni alpha tubulin 0.0388 0.5576 0.5576
Entamoeba histolytica tubulin alpha chain, putative 0.0388 0.5576 0.7262
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1936 0.1936
Schistosoma mansoni chromobox protein 0.0069 0.0749 0.0749
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0596 0.0596
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0254 0.3556 0.4637
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.5576 0.5564
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0139 0.0181
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0129 0.1664 0.1664
Echinococcus granulosus tubulin alpha chain 0.0388 0.5576 0.5564
Trypanosoma brucei epsilon tubulin 0.0318 0.4515 0.5888
Trichomonas vaginalis tubulin gamma chain, putative 0.0527 0.7668 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0139 0.0112
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.1664 0.217
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0139 0.0181
Trypanosoma brucei beta tubulin 0.0527 0.7668 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0459 0.0433
Echinococcus multilocularis tubulin alpha 1C chain 0.0388 0.5576 0.5564
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0139 0.0139
Echinococcus granulosus peroxisome assembly protein 26 0.0388 0.5576 0.5564
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0055 0.0072
Echinococcus granulosus tubulin alpha chain 0.0388 0.5576 0.5564
Brugia malayi Bromodomain containing protein 0.0062 0.0651 0.0849
Echinococcus multilocularis tubulin alpha chain 0.0388 0.5576 0.5564
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0749 0.0945
Toxoplasma gondii beta-tubulin, putative 0.0527 0.7668 1
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0943 0.0919
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.2513 0.2493
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0027 0.0035
Brugia malayi Importin beta-1 subunit 0.0028 0.014 0.0183
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0517 0.0675
Echinococcus multilocularis Tubulin beta 2C chain 0.0527 0.7668 0.7662
Echinococcus multilocularis tubulin alpha chain 0.0388 0.5576 0.5564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Schistosoma mansoni tubulin subunit alpha 0.0388 0.5576 0.5576
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0139 0.0139
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0139 0.0181
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0139 0.0181
Schistosoma mansoni lozenge 0.0055 0.0539 0.0539
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0422 0.0396
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0596 0.0778
Echinococcus multilocularis microtubule associated protein 2 0.0681 1 1
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0139 0.0139
Plasmodium vivax tubulin gamma chain, putative 0.0318 0.4521 0.5896
Echinococcus granulosus tubulin beta 4A class IVa 0.0527 0.7668 0.7662
Giardia lamblia CDC72 0.0216 0.2974 0.3857
Schistosoma mansoni coup transcription factor 0.0028 0.0139 0.0139
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0059 0.0042
Brugia malayi beta-tubulin, identical 0.0527 0.7668 1
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus multilocularis tubulin alpha chain 0.0388 0.5576 0.5564
Schistosoma mansoni tubulin subunit gamma 0.0318 0.4521 0.4521
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0216 0.2974 0.3857
Loa Loa (eye worm) tubulin gamma chain 0.0318 0.4521 0.5896
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0139 0.0112
Echinococcus granulosus tubulin subunit beta 0.0527 0.7668 0.7662
Echinococcus granulosus Tubulin beta 2C chain 0.0527 0.7668 0.7662
Echinococcus granulosus tubulin gamma 1 chain 0.0318 0.4521 0.4506
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.5576 0.5564
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0749 0.0724
Brugia malayi tubulin alpha chain - mouse 0.0388 0.5576 0.7272
Echinococcus multilocularis chromobox protein 1 0.0069 0.0749 0.0724
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0139 0.0112
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0749 0.0977
Loa Loa (eye worm) tubulin alpha chain 0.0388 0.5576 0.7272
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0459 0.0565
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0459 0.0598
Leishmania major beta tubulin 0.0527 0.7668 1
Loa Loa (eye worm) hypothetical protein 0.03 0.425 0.5542
Trypanosoma cruzi alpha tubulin, putative 0.0388 0.5576 0.7262
Onchocerca volvulus Alhambra homolog 0.0059 0.0596 0.0741
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0129 0.1664 0.2143
Echinococcus multilocularis tubulin subunit TubB 0.0388 0.5576 0.5564
Loa Loa (eye worm) beta-tubulin 0.0527 0.7668 1
Trypanosoma brucei alpha tubulin, putative 0.0158 0.2104 0.2744
Loa Loa (eye worm) tubulin beta chain 0.0134 0.1731 0.2257
Giardia lamblia Gamma tubulin 0.0318 0.4521 0.5882
Giardia lamblia PHD finger protein 15 0.0059 0.0596 0.0745
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0235
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0139 0.0139
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0055 0.0037
Leishmania major beta tubulin 0.0527 0.7668 1
Trypanosoma cruzi epsilon tubulin, putative 0.0318 0.4515 0.5874
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0139 0.0112
Brugia malayi RNA, U transporter 1 0.0081 0.0933 0.1217
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0783 0.0783
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0459 0.0565
Loa Loa (eye worm) hypothetical protein 0.023 0.3183 0.4151
Trichomonas vaginalis tubulin, putative 0.0527 0.7668 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0059 0.0042
Trypanosoma cruzi N-myristoyl transferase, putative 0.0216 0.2974 0.3857
Entamoeba histolytica tubulin family protein 0.0527 0.7668 1
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.5576 0.7262
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.1731 0.223
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0388 0.5576 0.7262
Plasmodium vivax tubulin alpha chain, putative 0.0388 0.5576 0.7272
Echinococcus multilocularis peroxisome assembly protein 26 0.0388 0.5576 0.5564
Echinococcus multilocularis tubulin epsilon chain 0.0318 0.4515 0.45
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0139 0.0112
Echinococcus multilocularis snurportin 1 0.0304 0.43 0.4285
Echinococcus granulosus tubulin subunit TubB 0.0388 0.5576 0.5564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0139 0.0139
Toxoplasma gondii alpha-tubulin I, putative 0.0388 0.5576 0.7272
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.5576 0.7262
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.5576 0.7262
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0422 0.055
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.5576 0.7262
Onchocerca volvulus 0.003 0.0167 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0422 0.0422
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0388 0.5576 0.5564
Echinococcus multilocularis beta tubulin 0.0527 0.7668 0.7662
Echinococcus multilocularis tubulin alpha 3 chain 0.0388 0.5576 0.5564
Trypanosoma cruzi zeta tubulin, putative 0.0405 0.5827 0.7591
Schistosoma mansoni microtubule-associated protein tau 0.0681 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Loa Loa (eye worm) hypothetical protein 0.0039 0.0293 0.0382
Trichomonas vaginalis tubulin gamma chain, putative 0.0318 0.4515 0.5874
Onchocerca volvulus 0.0437 0.6315 1
Leishmania major cytochrome p450-like protein 0.0023 0.0055 0.0037
Giardia lamblia Delta tubulin 0.0134 0.1731 0.223
Trypanosoma cruzi tubulin gamma chain 0.0318 0.4521 0.5882
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.0183
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0139 0.0112
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0139 0.0181
Brugia malayi Tubulin alpha-2 chain 0.0388 0.5576 0.7272
Leishmania major beta tubulin 0.0527 0.7668 1
Echinococcus granulosus tubulin delta chain 0.0134 0.1731 0.1709
Loa Loa (eye worm) hypothetical protein 0.0047 0.0422 0.055
Trypanosoma brucei epsilon tubulin 0.0318 0.4515 0.5888
Leishmania major beta tubulin 0.0527 0.7668 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0139 0.0181
Trichomonas vaginalis N-myristoyl transferase, putative 0.0142 0.1855 0.2392
Loa Loa (eye worm) tubulin alpha-3 chain 0.023 0.3183 0.4151
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0365 0.0476
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0139 0.0112
Loa Loa (eye worm) hypothetical protein 0.0054 0.052 0.0678
Brugia malayi Heterochromatin protein 1 0.0069 0.0749 0.0977
Trypanosoma brucei zeta tubulin, putative 0.0405 0.5827 0.7599
Echinococcus multilocularis Tubulin beta 2C chain 0.0527 0.7668 0.7662
Trichomonas vaginalis tubulin gamma chain, putative 0.0134 0.1731 0.223
Trichomonas vaginalis tubulin beta chain, putative 0.0388 0.5576 0.7262
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0527 0.7668 0.7662
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0129 0.1664 0.1642
Echinococcus multilocularis tubulin beta 1 chain 0.0527 0.7668 0.7662
Trypanosoma cruzi beta tubulin, putative 0.0527 0.7668 1
Brugia malayi alpha-tubulin 0.0388 0.5576 0.7272
Schistosoma mansoni ran 0.0021 0.0027 0.0027
Brugia malayi PHD-finger family protein 0.0059 0.0596 0.0778
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.052 0.0495
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0139 0.0139
Trypanosoma brucei alpha tubulin 0.0388 0.5576 0.7272
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0139 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0139 0.0181
Echinococcus granulosus peregrin 0.0062 0.0651 0.0626
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0459 0.0433
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0216 0.2974 0.3879
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0459 0.0565
Schistosoma mansoni tubulin subunit beta 0.0527 0.7668 0.7668
Trichomonas vaginalis tubulin alpha chain, putative 0.0527 0.7668 1
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0216 0.2974 0.3879
Plasmodium falciparum tubulin beta chain 0.0527 0.7668 1
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0139 0.0181
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0365 0.0442
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0422 0.0396
Leishmania major beta tubulin 0.0527 0.7668 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0139 0.0139
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.43 0.5608
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.2513 0.2493
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0139 0.0139
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0459 0.0433
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0139 0.0181
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0055 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0337 0.0406
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0139 0.0139
Echinococcus granulosus tubulin alpha 3 chain 0.0388 0.5576 0.5564
Echinococcus granulosus Tubulin alpha 1 chain 0.0388 0.5576 0.5564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0042
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0035
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0337 0.0406
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0459 0.0565
Brugia malayi nuclear receptor NHR-88 0.0028 0.0139 0.0181
Trypanosoma brucei tubulin delta chain 0.0296 0.4181 0.5453
Giardia lamblia Alpha-tubulin 0.0388 0.5576 0.7262
Brugia malayi Tubulin gamma chain 0.0318 0.4521 0.5896
Trypanosoma brucei beta tubulin 0.0527 0.7668 1
Trypanosoma cruzi epsilon tubulin, putative 0.0318 0.4515 0.5874
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0596 0.0571
Echinococcus granulosus tubulin alpha 3 chain 0.0388 0.5576 0.5564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Echinococcus granulosus beta tubulin 0.0527 0.7668 0.7662
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0181
Schistosoma mansoni hypothetical protein 0.0286 0.4034 0.4034
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0123 0.0125
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0139 0.0112
Echinococcus multilocularis Tubulin beta 2C chain 0.0527 0.7668 0.7662
Trypanosoma cruzi N-myristoyl transferase, putative 0.0216 0.2974 0.3857
Plasmodium vivax tubulin alpha chain, putative 0.0388 0.5576 0.7272
Echinococcus granulosus chromobox protein 1 0.0069 0.0749 0.0724
Trypanosoma cruzi tubulin delta chain 0.0296 0.4181 0.5437
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0139 0.0181
Trichomonas vaginalis tubulin epsilon chain, putative 0.0527 0.7668 1
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0302 0.0302
Leishmania major alpha tubulin 0.0388 0.5576 0.7262
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0783 0.0783
Loa Loa (eye worm) tubulin alpha chain 0.0388 0.5576 0.7272
Echinococcus multilocularis hypothetical protein 0.0388 0.5576 0.5564
Schistosoma mansoni tubulin subunit alpha 0.0388 0.5576 0.5576
Schistosoma mansoni tubulin subunit alpha 0.0134 0.1731 0.1731
Trypanosoma cruzi tubulin delta chain 0.0296 0.4181 0.5437
Trichomonas vaginalis tubulin epsilon chain, putative 0.0134 0.1731 0.223
Brugia malayi Muscleblind-like protein 0.03 0.425 0.5542
Echinococcus granulosus tubulin alpha 1C chain 0.0388 0.5576 0.5564
Leishmania major beta tubulin 0.0527 0.7668 1
Loa Loa (eye worm) tubulin alpha 2 0.0254 0.3556 0.4637
Echinococcus multilocularis tubulin gamma 1 chain 0.0318 0.4521 0.4506
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.014 0.0183
Schistosoma mansoni tubulin subunit epsilon 0.0318 0.4515 0.4515
Leishmania major gamma-tubulin 0.0318 0.4521 0.5882
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0139 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0139 0.0181
Loa Loa (eye worm) BEN-1 protein 0.0527 0.7668 1
Schistosoma mansoni hypothetical protein 0.0304 0.43 0.43
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0422 0.0422
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0158 0.2104 0.2718
Echinococcus granulosus beta tubulin 0.0527 0.7668 0.7662
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0216 0.0248
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0365 0.0339
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0139 0.0112
Brugia malayi hypothetical protein 0.0437 0.6315 0.8235
Entamoeba histolytica tubulin gamma chain 0.0318 0.4521 0.5882
Echinococcus granulosus importin subunit beta 1 0.0028 0.014 0.0114
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0596 0.0778
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0365 0.0476
Loa Loa (eye worm) tubulin alpha 2 0.0254 0.3556 0.4637
Mycobacterium leprae cell division protein FtsZ 0.0134 0.1731 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0139 0.0112
Echinococcus multilocularis peregrin 0.0062 0.0651 0.0626
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0139 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0123 0.0125
Plasmodium falciparum phd finger protein, putative 0.0059 0.0596 0.0778
Trypanosoma brucei alpha tubulin 0.0388 0.5576 0.7272
Trichomonas vaginalis tubulin alpha chain, putative 0.0158 0.2104 0.2718
Brugia malayi Tubulin beta chain 0.0158 0.2104 0.2744
Echinococcus multilocularis Protein lozenge 0.0055 0.0539 0.0513
Toxoplasma gondii tubulin, putative 0.0026 0.0101 0.0132
Trichomonas vaginalis tubulin, putative 0.016 0.2128 0.2749
Echinococcus multilocularis Tubulin beta 2C chain 0.0527 0.7668 0.7662
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0459 0.0565

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719
IC50 (binding) > 10 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719
Log IC50 (binding) = -1 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719
Log IC50 (binding) = -1 uM Inhibition of Candida albicans N-myristoyltransferse ChEMBL. 17349719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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