Detailed information for compound 507953

Basic information

Technical information
  • TDR Targets ID: 507953
  • Name: 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)et henyl]benzene-1,3-diamine dihydrochloride
  • MW: 403.3 | Formula: C18H24Cl2N2O4
  • H donors: 2 H acceptors: 0 LogP: 4.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(N)cc(cc1N)/C=C\c1cc(OC)c(c(c1)OC)OC.Cl.Cl
  • InChi: 1S/C18H22N2O4.2ClH/c1-21-15-9-12(10-16(22-2)18(15)24-4)6-5-11-7-13(19)17(23-3)14(20)8-11;;/h5-10H,19-20H2,1-4H3;2*1H/b6-5-;;
  • InChiKey: BJMGVQMNHYBVRI-XNOMRPDFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]benzene-1,3-diamine dihydrochloride
  • [3-amino-2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]amine dihydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0075 0.0138 0.0319
Brugia malayi nuclear receptor NHR-67 0.0035 0.0025 0.0058
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0609 0.0579
Brugia malayi putative neuropeptide receptor 0.0062 0.01 0.0231
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0121 0.028
Brugia malayi Tachykinin-like peptides receptor 99D 0.0062 0.01 0.0231
Brugia malayi sulfakinin receptor protein 0.0062 0.01 0.0231
Echinococcus multilocularis Regulator of G protein signaling 20 0.0043 0.0048 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0075 0.0138 0.0319
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0027 0.0586
Brugia malayi photoreceptor-specific nuclear receptor 0.0075 0.0138 0.0319
Echinococcus multilocularis thyroid hormone receptor alpha 0.0075 0.0138 0.058
Loa Loa (eye worm) hypothetical protein 0.0178 0.0431 0.0999
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0062 0.01 0.0231
Onchocerca volvulus 0.0038 0.0032 0.0037
Trypanosoma cruzi MFS transporter, putative 0.0148 0.0345 0.8009
Treponema pallidum hexokinase (hxk) 0.0083 0.0162 0.1408
Brugia malayi hypothetical protein 0.0148 0.0345 0.0801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Brugia malayi Melatonin receptor type 1A 0.0062 0.01 0.0231
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0349 0.3085
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.005 0.0153
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0051 0.0068 0.0236
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0178 0.0431 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.0544 0.1261
Onchocerca volvulus 0.0062 0.01 0.0195
Brugia malayi sodium-independent organic anion transporter family protein 0.0148 0.0345 0.0801
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.0048 0.0111
Brugia malayi intermediate filament protein 0.0057 0.0086 0.0198
Onchocerca volvulus Protein ultraspiracle homolog 0.0075 0.0138 0.0283
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Giardia lamblia Kinase, CMGC MAPK 0.01 0.0209 0.2614
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0012 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus granulosus hexokinase 0.0083 0.0162 0.0572
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0121 0.0507
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0075 0.0138 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0048 0.0575
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0248 0.3105
Loa Loa (eye worm) melatonin receptor type 1A 0.0062 0.01 0.0231
Brugia malayi GnHR receptor homolog 0.0062 0.01 0.0231
Echinococcus multilocularis agrin 0.0067 0.0116 0.0489
Onchocerca volvulus 0.0062 0.01 0.0195
Schistosoma mansoni RAR-like nuclear receptor 0.0075 0.0138 0.058
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.01 0.0418
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0075 0.0138 0.0486
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0062 0.01 0.035
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0044 0.005 0.0116
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0027 0.0317
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0105 0.037
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0012 0.0231
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0012 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.0138 0.0319
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.0025 0.0098
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0036 0.0027 0.0586
Loa Loa (eye worm) hypothetical protein 0.0043 0.0048 0.0111
Schistosoma mansoni hypothetical protein 0.0062 0.01 0.0395
Echinococcus granulosus allatostatin A receptor 0.0062 0.01 0.035
Echinococcus multilocularis chromobox protein 1 0.0073 0.0132 0.0556
Echinococcus granulosus lamin 0.0057 0.0086 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0007 0.006
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Toxoplasma gondii hexokinase 0.0083 0.0162 0.3719
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0007 0.006
Schistosoma mansoni hypothetical protein 0.0069 0.0121 0.0497
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0011 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0075 0.0138 0.058
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0209 0.2614
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0075 0.0138 0.058
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0148 0.0345 0.1471
Brugia malayi jmjC domain containing protein 0.0062 0.01 0.0231
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0067 0.0116 0.2661
Echinococcus granulosus mitogen activated protein kinase 0.01 0.0209 0.0743
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0062 0.01 0.0395
Echinococcus multilocularis expressed protein 0.0067 0.0116 0.0489
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.01 0.035
Echinococcus granulosus dro:myosuppressin receptor 0.0062 0.01 0.035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0025 0.0098
Echinococcus multilocularis geminin 0.0376 0.0991 0.4237
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0043 0.0048 0.0163
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0248 0.5734
Echinococcus granulosus solute carrier family 5 0.0043 0.0046 0.0156
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0248 0.0575
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0043 0.0046 0.1013
Brugia malayi ecdysteroid receptor 0.0075 0.0138 0.0319
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0062 0.01 0.0231
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0062 0.01 0.0418
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0248 0.2222
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0248 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Echinococcus granulosus g protein coupled receptor 0.0062 0.01 0.035
Schistosoma mansoni hypothetical protein 0.0376 0.0991 0.4757
Entamoeba histolytica hypothetical protein 0.0043 0.0048 0.0575
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0012 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0032 0.0691
Trichomonas vaginalis esterase, putative 0.0038 0.0032 0.0374
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0036 0.0027 0.009
Onchocerca volvulus 0.0035 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0157 0.0369 0.0855
Echinococcus multilocularis hexokinase 0.0083 0.0162 0.0683
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0067 0.0116 0.0269
Loa Loa (eye worm) hypothetical protein 0.0043 0.0048 0.0111
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0044 0.005 0.0116
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0051 0.0068 0.0282
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0032 0.0055
Loa Loa (eye worm) hypothetical protein 0.0148 0.0345 0.0801
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi tailless protein 0.0035 0.0025 0.0058
Brugia malayi G-protein coupled receptor 0.0062 0.01 0.0231
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.01 0.035
Echinococcus multilocularis solute carrier family 5 0.0043 0.0046 0.0186
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0025 0.0022
Echinococcus granulosus muscleblind protein 0.0157 0.0369 0.1316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Brugia malayi nuclear receptor RXR 0.004 0.0037 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0074
Schistosoma mansoni bromodomain containing protein 0.0066 0.0113 0.0459
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0051 0.0068 0.024
Echinococcus granulosus lamin dm0 0.0057 0.0086 0.0299
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0043 0.0046 0.0186
Schistosoma mansoni hypothetical protein 0.0069 0.0121 0.0497
Brugia malayi Dopamine receptor protein 2 0.0062 0.01 0.0231
Brugia malayi neuropeptide F receptor 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0043 0.0048 0.014
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0248 0.3105
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0075 0.0138 0.0319
Echinococcus multilocularis lamin dm0 0.0057 0.0086 0.0358
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0032 0.0106
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0012 0.0231
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0062 0.01 0.0395
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0005
Echinococcus multilocularis follistatin 0.0067 0.0116 0.0489
Brugia malayi G protein-coupled receptor 0.0062 0.01 0.0231
Schistosoma mansoni steroid hormone receptor ad4bp 0.0075 0.0138 0.058
Plasmodium vivax hexokinase, putative 0.0083 0.0162 0.3719
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0048 0.014
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0002 0.0001
Brugia malayi hypothetical protein 0.004 0.0037 0.0086
Echinococcus multilocularis serotonin receptor 0.0062 0.01 0.0418
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0062 0.01 0.0418
Brugia malayi Dopamine receptor 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0062 0.01 0.0418
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0043 0.0046 0.0156
Echinococcus granulosus somatostatin receptor 0.0062 0.01 0.035
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0753 0.2062 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0345 0.0801
Onchocerca volvulus 0.0067 0.0116 0.0234
Brugia malayi secreted modular calcium-binding protein 1 0.0067 0.0116 0.0269
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0032 0.0374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0074
Toxoplasma gondii ABC1 family protein 0.0038 0.0032 0.0691
Schistosoma mansoni agrin 0.0067 0.0116 0.0476
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0048 0.014
Echinococcus multilocularis allatostatin A receptor 0.0062 0.01 0.0418
Onchocerca volvulus 0.0062 0.01 0.0195
Echinococcus granulosus chromobox protein 1 0.0073 0.0132 0.0466
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0075 0.0138 0.0486
Schistosoma mansoni follistatin 0.0067 0.0116 0.0476
Onchocerca volvulus 0.0043 0.0046 0.0069
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0248 0.5734
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.0209 0.4828
Brugia malayi larval opioid receptor 0.0062 0.01 0.0231
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0132 0.1639
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0086 0.0198
Brugia malayi hypoxia-induced factor 1 0.0149 0.0348 0.0808
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.01 0.035
Trypanosoma brucei hexokinase 0.0083 0.0162 0.3719
Brugia malayi nuclear hormone receptor 0.0035 0.0025 0.0058
Schistosoma mansoni amine GPCR 0.0062 0.01 0.0395
Brugia malayi putative neuropeptide receptor NPR1 0.0062 0.01 0.0231
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.0319 0.1468
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0026 0.0102
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0027 0.0317
Echinococcus granulosus peptide allatostatin:somatostatin 0.0062 0.01 0.035
Onchocerca volvulus 0.0062 0.01 0.0195
Plasmodium falciparum hexokinase 0.0083 0.0162 0.3719
Loa Loa (eye worm) hypothetical protein 0.0051 0.0068 0.0158
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0025 0.0098
Schistosoma mansoni thyroid hormone receptor 0.0075 0.0138 0.058
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0062 0.01 0.035
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0405 0.1074 0.3176
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.0025 0.0058
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0025 0.003
Onchocerca volvulus 0.0062 0.01 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0459 0.5768
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni neuropeptide f receptor 76f 0.0062 0.01 0.0395
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0139 0.0319 0.1358
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.0138 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0075 0.0138 0.0319
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0027 0.0586
Echinococcus multilocularis regulator of G protein signaling 0.0043 0.0048 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0048 0.0575
Brugia malayi regulator of G-protein signaling egl-10 0.0043 0.0048 0.0111
Echinococcus granulosus high affinity choline transporter 1 0.0386 0.102 0.3653
Loa Loa (eye worm) steroid hormone receptor 0.0075 0.0138 0.0319
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.01 0.0395
Brugia malayi 6-phosphofructokinase 0.0114 0.0248 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0041 0.0489
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0046 0.0106
Schistosoma mansoni lamin 0.0057 0.0086 0.0326
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Schistosoma mansoni phosphoglycerate kinase 0.0178 0.0431 0.2015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0032 0.0074
Brugia malayi 6-phosphofructokinase 0.0114 0.0248 0.0575
Echinococcus granulosus neuropeptide FF receptor 2 0.0062 0.01 0.035
Onchocerca volvulus 0.0062 0.01 0.0195
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0032 0.0126
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.0019 0.0072
Echinococcus granulosus intermediate filament protein 0.0057 0.0086 0.0299
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Onchocerca volvulus 0.0075 0.0138 0.0283
Echinococcus granulosus hexokinase 0.0083 0.0162 0.0572
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0178 0.0431 0.1216
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.011 0.2527
Brugia malayi Hexokinase family protein 0.0052 0.0073 0.017
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0048 0.014
Brugia malayi Flap endonuclease-1 0.0027 0.0002 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0075 0.0138 0.0486
Onchocerca volvulus 0.0062 0.01 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0069 0.0239
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0139 0.0319 0.7392
Schistosoma mansoni neuropeptide receptor 0.0062 0.01 0.0395
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0012 0.0125
Schistosoma mansoni chromobox protein 0.0073 0.0132 0.0552
Brugia malayi G-protein coupled receptor 0.0062 0.01 0.0231
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0287 0.0739 0.1713
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.0544 0.1261
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0075 0.0138 0.0319
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0248 0.3105
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0037 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0048 0.0575
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.01 0.0418
Echinococcus granulosus fmrfamide receptor 0.0062 0.01 0.035
Chlamydia trachomatis recombinase RecA 0.0113 0.0246 0.22
Brugia malayi steroid hormone receptor 0.0075 0.0138 0.0319
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0062 0.01 0.0395
Loa Loa (eye worm) hypothetical protein 0.0041 0.0041 0.0095
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Schistosoma mansoni myosin xvIII 0.0062 0.01 0.0395
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0078 0.0146 0.3357
Schistosoma mansoni neuropeptide receptor 0.0062 0.01 0.0395
Leishmania major phosphoglycerate kinase B, cytosolic 0.0178 0.0431 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0121 0.0507
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0062 0.01 0.0395
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.2335 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0069 0.0244
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0067 0.0116 0.2661
Trichomonas vaginalis chromobox protein, putative 0.0044 0.005 0.06
Brugia malayi nuclear receptor NHR-88 0.0035 0.0025 0.0058
Schistosoma mansoni single-minded 0.0048 0.0062 0.0208
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.01 0.0418
Loa Loa (eye worm) hexokinase type II 0.0083 0.0162 0.0375
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0209 0.2614
Chlamydia trachomatis phosphoglycerate kinase 0.0178 0.0431 0.3944
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.01 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0075 0.0138 0.0319
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0074
Echinococcus granulosus hypothetical protein 0.0062 0.01 0.035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0044 0.005 0.0116
Echinococcus multilocularis beta adrenergic receptor kinase 0.0044 0.005 0.0206
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0027 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0459 0.5768
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0248 0.3105
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0048 0.0575
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.01 0.0395
Onchocerca volvulus Neuropeptide F receptor homolog 0.0062 0.01 0.0195
Entamoeba histolytica hypothetical protein 0.0043 0.0048 0.0575
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0148 0.0345 0.0801
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0349 0.0318
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0048 0.0163
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.0319 0.1468
Echinococcus granulosus alpha 1A adrenergic receptor 0.0062 0.01 0.035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0032 0.0062
Echinococcus multilocularis chromobox protein 1 0.0073 0.0132 0.0556
Brugia malayi MAP kinase sur-1 0.01 0.0209 0.0485
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.005 0.0153
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.0544 0.1261
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0487 0.6132
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0041 0.0489
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0105 0.0422
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.0019 0.0394
Schistosoma mansoni opsin-like receptor 0.0062 0.01 0.0395
Schistosoma mansoni axis inhibition protein axin 0.0043 0.0048 0.014
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0148 0.0345 0.1471
Leishmania major eukaryotic translation initiation factor-like 0.0036 0.0027 0.0586
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0459 0.5768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.0794 1
Onchocerca volvulus Putative organic anion transporter 0.1546 0.4311 1
Brugia malayi hexokinase 0.0083 0.0162 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0075 0.0138 0.0319
Brugia malayi A-kinase anchor protein 10, precursor 0.0043 0.0048 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.01 0.035
Schistosoma mansoni chromobox protein 0.0073 0.0132 0.0552
Brugia malayi Bromodomain containing protein 0.0079 0.0148 0.0343
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.0739 0.9304
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.0794 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.0138 0.0319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0075 0.0138 0.058
Echinococcus multilocularis phosphoglycerate kinase 1 0.0178 0.0431 0.1837
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0025 0.0082
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0062 0.01 0.035
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0121 0.028
Loa Loa (eye worm) hypothetical protein 0.004 0.0037 0.0086
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0067 0.0116 0.0269
Loa Loa (eye worm) hexokinase 0.0083 0.0162 0.0375
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0062 0.01 0.0395
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0074
Onchocerca volvulus 0.0062 0.01 0.0195
Schistosoma mansoni growth hormone secretagogue receptor 0.0062 0.01 0.0395
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni biogenic amine receptor 0.0062 0.01 0.0395
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0369 0.1571
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) agrin synaptic family protein 0.0067 0.0116 0.0269
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Echinococcus multilocularis neuropeptide receptor 0.0062 0.01 0.0418
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.01 0.0231
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.004 0.0037 0.0089
Brugia malayi RE15519p 0.0062 0.01 0.0231
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.0048 0.014
Echinococcus multilocularis hexokinase 0.0083 0.0162 0.0683
Loa Loa (eye worm) hypothetical protein 0.0157 0.0369 0.0855
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0062 0.01 0.0231
Toxoplasma gondii protease inhibitor PI2 0.0067 0.0116 0.2661
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0032 0.0127
Loa Loa (eye worm) hypothetical protein 0.0523 0.141 0.327
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0459 0.5768
Loa Loa (eye worm) hypothetical protein 0.0043 0.0048 0.0111
Echinococcus granulosus sex peptide receptor 0.0062 0.01 0.035
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0062 0.01 0.035
Brugia malayi regulator of G-protein signaling rgs-7 0.0043 0.0048 0.0111
Schistosoma mansoni histamine h1 receptor 0.0062 0.01 0.0395
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0248 0.112
Echinococcus multilocularis g protein coupled receptor 0.0062 0.01 0.0418
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.0319 0.2796
Onchocerca volvulus 0.0057 0.0086 0.0163
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0048 0.0195
Schistosoma mansoni thyroid hormone receptor 0.0075 0.0138 0.058
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Echinococcus granulosus hexokinase 0.0083 0.0162 0.0572
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.01 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0048 0.0575
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Onchocerca volvulus 0.0148 0.0345 0.0767
Echinococcus multilocularis ecdysone induced protein 78C 0.0075 0.0138 0.058
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0348 0.0808
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0062 0.01 0.0231
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.0025 0.0058
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0048 0.0163
Brugia malayi Serotonin receptor 0.0062 0.01 0.0231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.01 0.0418
Trypanosoma cruzi hexokinase, putative 0.0083 0.0162 0.3719
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0248 0.3105
Trypanosoma cruzi hexokinase, putative 0.0083 0.0162 0.3719
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.01 0.0418
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.0019 0.0394
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0287 0.0739 0.1713
Loa Loa (eye worm) nuclear hormone receptor 0.0035 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0148 0.0345 0.0801
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.0209 0.0887
Echinococcus multilocularis neuropeptide receptor A26 0.0062 0.01 0.0418
Loa Loa (eye worm) hypothetical protein 0.0148 0.0345 0.0801
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0062 0.01 0.0418
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0012 0.0125
Brugia malayi hypothetical protein 0.0035 0.0025 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.0138 0.0319
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.0319 0.2796
Schistosoma mansoni adenoreceptor 0.0062 0.01 0.0395
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0067 0.0116 0.2661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Treponema pallidum phosphoglycerate kinase 0.0178 0.0431 0.3944
Echinococcus multilocularis lamin 0.0057 0.0086 0.0358
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0032 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0048 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0069 0.0286
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0075 0.0138 0.0486
Onchocerca volvulus 0.0036 0.0026 0.0024
Onchocerca volvulus 0.0062 0.01 0.0195
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.0209 0.4828
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0121 0.0425
Schistosoma mansoni lamin 0.0057 0.0086 0.0326
Schistosoma mansoni intermediate filament proteins 0.0057 0.0086 0.0326
Schistosoma mansoni hypothetical protein 0.0149 0.0348 0.1609
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.0025 0.003
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0023 0.0498
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0075 0.0138 0.058
Onchocerca volvulus 0.0038 0.0032 0.0037
Loa Loa (eye worm) translation initiation factor 4E 0.0036 0.0027 0.0063
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.01 0.0418
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0062 0.01 0.0418
Brugia malayi SPARC precursor 0.0067 0.0116 0.0269
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0062 0.01 0.0231
Brugia malayi hypothetical protein 0.0162 0.0384 0.0891
Loa Loa (eye worm) hypothetical protein 0.0043 0.0048 0.0111
Entamoeba histolytica hexokinase 2 0.0083 0.0162 0.2014
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Echinococcus granulosus follistatin 0.0067 0.0116 0.0409
Echinococcus multilocularis dro:myosuppressin receptor 0.0062 0.01 0.0418
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0046 0.0055 0.0175
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.01 0.0231
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0209 0.2614
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.011 0.2527
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0113 0.0246 0.0652
Loa Loa (eye worm) TYRA-2 protein 0.0062 0.01 0.0231
Mycobacterium ulcerans lipase LipD 0.0038 0.0032 0.0055
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0405 0.1074 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.0319 0.2796
Schistosoma mansoni phosphoglycerate kinase 0.0178 0.0431 0.2015
Onchocerca volvulus 0.0062 0.01 0.0195
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Schistosoma mansoni z-protein (S1r protein) 0.0043 0.0048 0.014
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0012 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni coup transcription factor 0.0075 0.0138 0.058
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi ORL1-like opioid receptor 0.0062 0.01 0.0231
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.0025 0.003
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Brugia malayi Sodium:solute symporter family protein 0.0043 0.0046 0.0106
Echinococcus granulosus sodium:glucose cotransporter 0.0043 0.0046 0.0156
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.01 0.0418
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0062 0.01 0.0418
Schistosoma mansoni nuclear receptor 0.0035 0.0025 0.003
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.0209 0.0887
Schistosoma mansoni alpha-1 adrenergic receptor 0.0062 0.01 0.0395
Mycobacterium ulcerans beta-lactamase 0.0038 0.0032 0.0055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0102 0.0359
Brugia malayi G protein-coupled receptor F59B2.13 0.0062 0.01 0.0231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0405 0.1074 1
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0036 0.0027 0.004
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0209 0.093
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.0209 0.4828
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.0025 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0069 0.0239
Schistosoma mansoni hypothetical protein 0.0069 0.0121 0.0497
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.01 0.035
Echinococcus granulosus beta-adrenergic receptor kinase 0.0044 0.005 0.0173
Echinococcus multilocularis orexin receptor type 2 0.0062 0.01 0.0418
Loa Loa (eye worm) hypothetical protein 0.0056 0.0083 0.0192
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni biogenic amine receptor 0.0062 0.01 0.0395
Leishmania major hexokinase, putative 0.0083 0.0162 0.3719
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.01 0.0395
Onchocerca volvulus 0.0062 0.01 0.0195
Trypanosoma brucei protein kinase, putative 0.01 0.0209 0.4828
Echinococcus multilocularis muscleblind protein 0.0157 0.0369 0.1571
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0037 0.0086
Loa Loa (eye worm) hexokinase 0.0052 0.0073 0.017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.004 0.0037 0.0126
Onchocerca volvulus 0.0062 0.01 0.0195
Mycobacterium ulcerans recombinase A 0.0113 0.0246 0.2095
Brugia malayi PAS domain containing protein 0.0048 0.0062 0.0143
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0248 0.5734
Giardia lamblia Phosphoglycerate kinase 0.0178 0.0431 0.5415
Brugia malayi Steroid receptor seven-up type 2 0.0075 0.0138 0.0319
Schistosoma mansoni organic anion transporter 0.0148 0.0345 0.1597
Brugia malayi ThiF family protein 0.0033 0.0019 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.0037 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.0138 0.0486
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.0209 0.4828
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0105 0.0422
Echinococcus multilocularis GPCR, family 2 0.0069 0.0121 0.0507
Onchocerca volvulus Putative organic anion transporter 0.0148 0.0345 0.0767
Loa Loa (eye worm) hypothetical protein 0.0043 0.0048 0.0111
Brugia malayi PXA domain containing protein 0.0043 0.0048 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0178 0.0431 1
Brugia malayi Phosphoglycerate kinase 0.0178 0.0431 0.0999
Schistosoma mansoni high-affinity choline transporter 0.0386 0.102 0.49
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0036 0.0027 0.0586
Loa Loa (eye worm) hypothetical protein 0.0074 0.0135 0.0313
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0178 0.0431 0.5415
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0035 0.0023 0.0498
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.004 0.0037 0.015
Trypanosoma brucei phosphoglycerate kinase 0.0178 0.0431 1
Echinococcus granulosus agrin 0.0067 0.0116 0.0409
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0027 0.0317
Onchocerca volvulus 0.0523 0.141 0.3245
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0067 0.0116 0.0269
Schistosoma mansoni retinoic acid receptor RXR 0.0075 0.0138 0.058
Loa Loa (eye worm) hypothetical protein 0.0149 0.0348 0.0807
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.01 0.035
Brugia malayi Serotonin receptor 0.0062 0.01 0.0231
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0075 0.0138 0.0486
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.0048 0.0163
Brugia malayi hypothetical protein 0.0043 0.0048 0.0111
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0248 0.3105
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0178 0.0431 0.2236
Loa Loa (eye worm) hypothetical protein 0.0148 0.0345 0.0801
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0032 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0048 0.0575
Loa Loa (eye worm) hypothetical protein 0.0043 0.0048 0.0111
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.01 0.0418
Brugia malayi Heterochromatin protein 1 0.0073 0.0132 0.0306
Toxoplasma gondii transporter, major facilitator family protein 0.0148 0.0345 0.8009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0121 0.0425
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0043 0.0048 0.014
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.01 0.0395
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0012 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0075 0.0138 0.058
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.02
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0012 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0075 0.0138 0.0319
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.0209 0.4828
Echinococcus multilocularis g protein coupled receptor 0.0062 0.01 0.0418
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.0209 0.4828
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.0048 0.0195
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0248 0.0882
Loa Loa (eye worm) hypothetical protein 0.0523 0.141 0.327
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.0025 0.0082
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0139 0.0319 0.1137
Echinococcus multilocularis musashi 0.0057 0.0086 0.0358
Brugia malayi beta-lactamase family protein 0.0038 0.0032 0.0074
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0062 0.01 0.0418
Onchocerca volvulus 0.0035 0.0025 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.01 0.0395
Schistosoma mansoni inositol transporter 0.0043 0.0046 0.013
Brugia malayi nuclear receptor RXR 0.0035 0.0025 0.0058
Loa Loa (eye worm) beta-lactamase 0.0038 0.0032 0.0074
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.01 0.0418
Trichomonas vaginalis chromobox protein, putative 0.0044 0.005 0.06
Loa Loa (eye worm) PXA domain-containing protein 0.0043 0.0048 0.0111
Schistosoma mansoni axis inhibition protein axin 0.0043 0.0048 0.014
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.01 0.0395
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0075 0.0138 0.0486
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0023 0.0498
Leishmania major phosphoglycerate kinase C, glycosomal 0.0178 0.0431 1
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.01 0.0231
Mycobacterium leprae Conserved hypothetical protein 0.1194 0.3312 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0062 0.01 0.0231
Echinococcus granulosus neuropeptide receptor 0.0062 0.01 0.035
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0027 0.0317
Onchocerca volvulus Hexokinase homolog 0.0052 0.0073 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0075 0.0138 0.0319
Brugia malayi Regulator of G protein signaling domain containing protein 0.0043 0.0048 0.0111
Onchocerca volvulus 0.0062 0.01 0.0195
Echinococcus granulosus 7TM GPCR rhodopsin 0.0062 0.01 0.035
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0062 0.01 0.0418
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0248 0.2118
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0012 0.0231
Schistosoma mansoni opsin-like receptor 0.0062 0.01 0.0395
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0069 0.0286
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0032 0.0374
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.011 0.2527
Echinococcus granulosus neuropeptide s receptor 0.0062 0.01 0.035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0121 0.028
Brugia malayi translation initiation factor 4E 0.0036 0.0027 0.0063
Brugia malayi phosphofructokinase 0.0114 0.0248 0.0575
Toxoplasma gondii aldehyde dehydrogenase 0.0139 0.0319 0.7392
Loa Loa (eye worm) hypothetical protein 0.0218 0.0544 0.1261
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0027 0.0317
Onchocerca volvulus Glucosylceramidase homolog 0.0188 0.0459 0.1031
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.01 0.035
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0248 0.3105
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0062 0.01 0.0395
Loa Loa (eye worm) DR-78 0.0035 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0067 0.0116 0.0269
Brugia malayi sodium-independent organic anion transporter family protein 0.0148 0.0345 0.0801
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.011 0.2527
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.0487 0.6132
Echinococcus granulosus serotonin receptor 0.0062 0.01 0.035
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.01 0.035
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0043 0.0048 0.0575
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0043 0.0046 0.0186
Schistosoma mansoni opsin-like receptor 0.0062 0.01 0.0395
Brugia malayi ThiF family protein 0.0051 0.0068 0.0158
Treponema pallidum fructose-bisphosphate aldolase 0.0306 0.0794 0.7363
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0069 0.0244
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0025 0.003
Echinococcus granulosus Solute carrier family 22 5 0.101 0.2788 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.01 0.035
Mycobacterium ulcerans hypothetical protein 0.0038 0.0032 0.0055
Onchocerca volvulus 0.0062 0.01 0.0195
Brugia malayi prostaglandin transporter 0.1546 0.4311 1
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0025 0.0058
Onchocerca volvulus 0.0083 0.0162 0.0339
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Entamoeba histolytica hypothetical protein 0.0043 0.0048 0.0575
Brugia malayi sodium-independent organic anion transporter family protein 0.0148 0.0345 0.0801
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0132 0.1639
Schistosoma mansoni neuropeptide receptor 0.0062 0.01 0.0395
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.004 0.0037 0.0086
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0012 0.0125
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.0025 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.01 0.035
Echinococcus multilocularis sex peptide receptor 0.0062 0.01 0.0418
Echinococcus multilocularis Protein lozenge 0.0066 0.0111 0.0466
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.0019 0.0061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0116 0.0269
Onchocerca volvulus Bile acid receptor homolog 0.0075 0.0138 0.0283
Schistosoma mansoni Replicative DNA helicase 0.0405 0.1074 0.5162
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0148 0.0345 0.1232
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Trypanosoma brucei phosphoglycerate kinase 0.0178 0.0431 1
Treponema pallidum recombinase A 0.0113 0.0246 0.22
Brugia malayi GH02984p 0.0386 0.102 0.2366
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0069 0.016
Echinococcus granulosus neuropeptide receptor A26 0.0062 0.01 0.035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0459 0.5768
Schistosoma mansoni lozenge 0.0066 0.0111 0.045
Onchocerca volvulus 0.0062 0.01 0.0195
Brugia malayi nuclear hormone receptor 0.0075 0.0138 0.0319
Brugia malayi Muscleblind-like protein 0.0157 0.0369 0.0855
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0025 0.0058
Echinococcus granulosus single minded 2 0.0036 0.0026 0.0086
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0062 0.01 0.0395
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0062 0.01 0.0231
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.01 0.035
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0248 0.0575
Echinococcus multilocularis g-protein coupled receptor 0.0062 0.01 0.0418
Schistosoma mansoni hypothetical protein 0.0062 0.01 0.0395
Echinococcus multilocularis high affinity choline transporter 1 0.0386 0.102 0.4363
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.0019 0.0394
Leishmania major eukaryotic translation initiation factor-like protein 0.0036 0.0027 0.0586
Plasmodium falciparum phosphoglycerate kinase 0.0178 0.0431 1
Echinococcus granulosus axis inhibition protein axin 0.0043 0.0048 0.0163
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.0138 0.0319
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.01 0.035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.0138 0.058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Schistosoma mansoni amine GPCR 0.0062 0.01 0.0395
Schistosoma mansoni amine GPCR 0.0062 0.01 0.0395
Loa Loa (eye worm) hypothetical protein 0.0043 0.0046 0.0106
Brugia malayi Hexokinase family protein 0.0083 0.0162 0.0375
Echinococcus granulosus g protein coupled receptor 0.0062 0.01 0.035
Echinococcus granulosus sodium:myo inositol cotransporter 0.0043 0.0046 0.0156
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0514 0.1383 0.3208
Onchocerca volvulus 0.0052 0.0073 0.0134
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0048 0.014
Onchocerca volvulus 0.0038 0.0032 0.0037
Entamoeba histolytica phosphoglycerate kinase, putative 0.0178 0.0431 0.5415
Onchocerca volvulus 0.0062 0.01 0.0195
Brugia malayi neuropeptide F receptor 0.0062 0.01 0.0231
Echinococcus granulosus hexokinase type 2 0.0083 0.0162 0.0572
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0248 0.0659
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0062 0.01 0.0418
Echinococcus granulosus neuropeptide receptor 0.0062 0.01 0.035
Trypanosoma brucei hexokinase 0.0083 0.0162 0.3719
Loa Loa (eye worm) hypothetical protein 0.0067 0.0116 0.0269
Brugia malayi beta-lactamase 0.0038 0.0032 0.0074
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0139 0.0319 0.0288
Echinococcus granulosus Regulator of G protein signaling 20 0.0043 0.0048 0.0163
Brugia malayi AKH receptor 0.0062 0.01 0.0231
Leishmania major hexokinase, putative 0.0083 0.0162 0.3719
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0036 0.0027 0.0586
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.0048 0.0195
Echinococcus granulosus tachykinin peptides receptor 99D 0.0062 0.01 0.035
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.01 0.035
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0043 0.0046 0.0186
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0011 0.0025
Schistosoma mansoni hypothetical protein 0.0376 0.0991 0.4757
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.01 0.035
Echinococcus granulosus FTZ F1 alpha 0.0075 0.0138 0.0486
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0102 0.0429
Brugia malayi hypothetical protein 0.0043 0.0048 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.0739 0.9304
Brugia malayi chromobox protein homolog 3 0.0041 0.0041 0.0095
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0041 0.0058
Brugia malayi hypothetical protein 0.0523 0.141 0.327
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0078 0.0146 0.3357
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0067 0.0116 0.2661
Echinococcus multilocularis hexokinase 0.0083 0.0162 0.0683
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.0209 0.4828
Schistosoma mansoni biogenic amine receptor 0.0062 0.01 0.0395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.0138 0.0319
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0062 0.0208
Onchocerca volvulus 0.0062 0.01 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0069 0.0244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0069 0.016
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.004 0.0037 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0032 0.0374
Loa Loa (eye worm) hypothetical protein 0.1546 0.4311 1
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0086 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.0739 0.9304
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0105 0.0244
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Echinococcus granulosus G protein coupled receptor 139 0.0062 0.01 0.035
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0178 0.0431 0.04
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.0019 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0075 0.0138 0.0319
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0075 0.0138 0.058
Brugia malayi jmjC domain containing protein 0.0064 0.0105 0.0244
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0067 0.0116 0.0269
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0043 0.0048 0.0195
Echinococcus granulosus GPCR family 2 0.0069 0.0121 0.0425
Echinococcus multilocularis neuropeptide receptor 0.0062 0.01 0.0418
Schistosoma mansoni nuclear hormone receptor 0.0075 0.0138 0.058
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0026 0.006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0349 0.0968
Echinococcus multilocularis G protein coupled receptor 139 0.0062 0.01 0.0418
Loa Loa (eye worm) hypothetical protein 0.0148 0.0345 0.0801
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0025 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0075 0.0138 0.0319
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.0739 0.9304
Echinococcus multilocularis axis inhibition protein axin 0.0043 0.0048 0.0195
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.01 0.035
Brugia malayi follicle stimulating hormone receptor 0.0514 0.1383 0.3208
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0062 0.01 0.0231
Brugia malayi PXA domain containing protein 0.0043 0.0048 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.0138 0.058
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0012 0.0125
Echinococcus granulosus Solute carrier organic anion transporter family 0.0148 0.0345 0.1232
Treponema pallidum replicative DNA helicase (dnaB) 0.0405 0.1074 1
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0032 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Echinococcus granulosus regulator of G protein signaling 3 0.0043 0.0048 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.0138 0.0319
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0075 0.0138 0.058
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0067 0.0116 0.0269
Loa Loa (eye worm) RGS-3 protein 0.0043 0.0048 0.0111
Loa Loa (eye worm) runx1 0.0066 0.0111 0.0257
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0051 0.0068 0.1538
Echinococcus multilocularis neuropeptide FF receptor 2 0.0062 0.01 0.0418
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0032 0.0106
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.0025 0.0082
Echinococcus multilocularis fmrfamide receptor 0.0062 0.01 0.0418
Brugia malayi Dopamine receptor protein 1 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0074
Echinococcus multilocularis FTZ F1 alpha 0.0075 0.0138 0.058
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0035 0.0025 0.0098
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.01 0.035
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0062 0.01 0.0395
Onchocerca volvulus 0.0083 0.0162 0.0339
Trypanosoma brucei hexokinase, putative 0.0083 0.0162 0.3719
Echinococcus granulosus orexin receptor type 2 0.0062 0.01 0.035
Brugia malayi conserved hypotetical protein 0.0035 0.0025 0.0058
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0002 0.0005
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.01 0.0395
Schistosoma mansoni nuclear receptor 0.0035 0.0025 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.01 0.0395
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.01 0.0418
Toxoplasma gondii hypothetical protein 0.0051 0.0068 0.1538
Loa Loa (eye worm) hypothetical protein 0.0032 0.0016 0.0036
Schistosoma mansoni neuropeptide receptor 0.0062 0.01 0.0395
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0048 0.0195
Echinococcus multilocularis serotonin receptor 0.0062 0.01 0.0418
Echinococcus multilocularis regulator of G protein signaling 3 0.0043 0.0048 0.0195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.01 0.0418
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0459 0.5768
Echinococcus granulosus g protein coupled receptor 0.0062 0.01 0.035
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0012 0.0231
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0032 0.0374
Echinococcus multilocularis g protein coupled receptor 0.0062 0.01 0.0418
Toxoplasma gondii ThiF family protein 0.0033 0.0019 0.0394
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.01 0.0418
Brugia malayi beta-lactamase family protein 0.0038 0.0032 0.0074
Schistosoma mansoni inositol transporter 0.0043 0.0046 0.013
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0062 0.01 0.0418
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0025 0.0082
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni hypothetical protein 0.0069 0.0121 0.0497
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.0739 0.9304
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0035 0.0025 0.0058
Giardia lamblia Fructose-bisphosphate aldolase 0.0306 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni amine GPCR 0.0062 0.01 0.0395
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.01 0.035
Echinococcus multilocularis hexokinase type 2 0.0083 0.0162 0.0683
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Onchocerca volvulus 0.0148 0.0345 0.0767
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0058
Onchocerca volvulus 0.0148 0.0345 0.0767
Mycobacterium ulcerans phosphoglycerate kinase 0.0178 0.0431 0.3863
Echinococcus granulosus phosphoglycerate kinase 1 0.0178 0.0431 0.1538
Loa Loa (eye worm) hypothetical protein 0.004 0.0037 0.0086
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0078 0.0146 0.3357
Echinococcus granulosus axis inhibition protein axin 0.0043 0.0048 0.0163
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) twinkle helicase 0.0116 0.0253 0.0587
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0132 0.0306
Leishmania major hypothetical protein, conserved 0.0038 0.0032 0.0691
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0012 0.0125
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0032 0.0691
Brugia malayi hypothetical protein 0.0148 0.0345 0.0801
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0075 0.0138 0.0319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0025 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0075 0.0138 0.0319
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0062 0.01 0.0195
Loa Loa (eye worm) hypothetical protein 0.0386 0.102 0.2366
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.01 0.035
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0036 0.0027 0.0108
Brugia malayi Phosphoglycerate kinase 0.0065 0.011 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.0739 0.9304
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.0019 0.0394
Brugia malayi hypothetical protein 0.0062 0.01 0.0231
Schistosoma mansoni hypothetical protein 0.0062 0.01 0.0395
Schistosoma mansoni amine GPCR 0.0062 0.01 0.0395
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.326 0.9172 0.9169
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0043 0.0048 0.0111
Echinococcus multilocularis fmrfamide receptor 0.0062 0.01 0.0418
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0209 0.2614
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Plasmodium vivax ubiquitin activating enzyme, putative 0.0051 0.0068 0.1538
Brugia malayi Bromodomain containing protein 0.004 0.0039 0.0089
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0178 0.0431 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Loa Loa (eye worm) hypothetical protein 0.0069 0.0121 0.028
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0032 0.0691
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0086 0.0198
Echinococcus granulosus geminin 0.0376 0.0991 0.3548
Onchocerca volvulus 0.0057 0.0086 0.0163
Echinococcus granulosus 7tm_1 domain containing protein 0.0062 0.01 0.035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0032 0.0062
Loa Loa (eye worm) hexokinase 0.0083 0.0162 0.0375
Loa Loa (eye worm) hypothetical protein 0.004 0.0039 0.009
Echinococcus granulosus expressed protein 0.0844 0.2319 0.8314
Schistosoma mansoni hypothetical protein 0.0062 0.01 0.0395
Echinococcus granulosus sodium:glucose cotransporter 2 0.0043 0.0046 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0075 0.0138 0.0319
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0075 0.0138 0.058
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0029 0.0006 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.0138 0.0319
Schistosoma mansoni sodium/solute symporter 0.0043 0.0046 0.013
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.0209 0.0743
Schistosoma mansoni jumonji domain containing protein 0.0062 0.01 0.0394
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0012 0.0125
Onchocerca volvulus 0.0148 0.0345 0.0767
Loa Loa (eye worm) hypothetical protein 0.0045 0.0052 0.0119
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0074
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0062 0.01 0.0231
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0025 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.0062 0.01 0.0418
Entamoeba histolytica hexokinase 1 0.0083 0.0162 0.2014
Echinococcus granulosus chromobox protein 1 0.0073 0.0132 0.0466
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0248 0.112
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0075 0.0138 0.058
Loa Loa (eye worm) hypothetical protein 0.004 0.0037 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.005 0.0153
Schistosoma mansoni hexokinase 0.0083 0.0162 0.0698
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0459 0.5768
Brugia malayi hypothetical protein 0.004 0.0037 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0178 0.0431 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0032 0.0691
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.0209 0.4828
Echinococcus granulosus g-protein coupled receptor 0.0062 0.01 0.035
Loa Loa (eye worm) ThiF family protein 0.0033 0.0019 0.0044
Schistosoma mansoni organic anion transporter 0.0148 0.0345 0.1597
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.0025 0.0082
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0248 0.1053
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi hypothetical protein 0.0035 0.0025 0.0058
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.011 0.2527
Onchocerca volvulus Putative organic anion transporter 0.0148 0.0345 0.0767
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0348 0.0807
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0116 0.0269
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.005 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Onchocerca volvulus 0.0148 0.0345 0.0767
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.0209 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.01 0.0395
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0075 0.0138 0.0283
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0037 0.0086
Loa Loa (eye worm) hypothetical protein 0.0075 0.0138 0.0319
Onchocerca volvulus 0.0083 0.0162 0.0339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.0794 1
Brugia malayi nuclear receptor NHR-88 0.0075 0.0138 0.0319
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.0025 0.0098
Echinococcus multilocularis somatostatin receptor 0.0062 0.01 0.0418
Plasmodium vivax phosphoglycerate kinase, putative 0.0178 0.0431 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0248 0.0575
Brugia malayi ecdysone receptor 0.0035 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0062 0.01 0.0231
Echinococcus multilocularis expressed protein 0.0844 0.2319 0.9928
Chlamydia trachomatis replicative DNA helicase 0.0405 0.1074 1
Schistosoma mansoni zinc finger protein 0.0035 0.0025 0.003
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0178 0.0431 0.5415
Loa Loa (eye worm) hypothetical protein 0.0162 0.0384 0.0891
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0198

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Reduction of blood flow to tumor in MHEC5-T xenografted SCID mouse at 10 mg/kg, ip after 24 hrs ChEMBL. 18303849
Activity (functional) = 0 % Reduction of blood flow to tumor in MHEC5-T xenografted SCID mouse at 10 mg/kg, ip after 24 hrs ChEMBL. 18303849
Activity (functional) = 6 % Reduction of blood flow to tumor in MHEC5-T xenografted SCID mouse at 100 mg/kg, ip after 24 hrs ChEMBL. 18303849
Activity (functional) = 6 % Reduction of blood flow to tumor in MHEC5-T xenografted SCID mouse at 100 mg/kg, ip after 24 hrs ChEMBL. 18303849
IC50 (functional) > 1.4 uM Cytotoxicity against mouse MHEC5-T cells after 5 days by MTT assay ChEMBL. 18303849
IC50 (binding) > 40 uM Inhibition of calf tubulin polymerization ChEMBL. 18303849
IC50 (functional) > 44.8 uM Cytotoxicity against mouse MHEC5-T cells after 1 hr by MTT assay ChEMBL. 18303849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.